MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cardiomyopathy, Dilated

(UMLS:C0007193)

Definition:: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
UMLS ID:: C0007193
MeSH ID:: D002311

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.195.160|C14.280.238.070

Synonym(s)

Cardiomyopathy, Dilated

CARDIOMYOPATHY DILATED

CCM - Congestive cardiomyopathy

COCM - Congestive cardiomyopathy

Cardiomyopathy, dilated

Cardiomyopathy;congestive

Congestive Cardiomyopathy

Congestive cardiomyopathy

Congestive dilated cardiomyopathy

10.

DCM - Dilated cardiomyopathy

11.

Dilated Cardiomyopathy

12.

Dilated cardiomyopathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Albuterol	19081299	CTD
2	Alcohols	12198386	CTD
3	Amiodarone	15710769 19225199	CTD
4	Amitriptyline	16040888 17100146	CTD
5	Amphetamine	16738435 19536382	CTD
6	Antimony	10334427	CTD
7	Atenolol	9623012	CTD
8	Azathioprine	11435335	CTD
9	Bromocriptine	15173554	CTD
10	Carnitine	16040888	CTD
11	Carvedilol	View details 9789703 10981864 11496434 11986409 16682315 17395050 17711797 18075464 18593848 18971572 19477965 20019332	CTD
12	Ceftriaxone	8877079	CTD
13	Cisapride	16040888	CTD
14	Clozapine	View details 11561489 11718172 12075045 12897222 16503709 18628775	CTD
15	Cocaine	View details 1858646 1926265 3766598 7750342 8327745 8465736 10069205 11377647 15688670 17482989 17868884 18202230 19463023 20109599	CTD
16	Digoxin	2722306 9838955	CTD
17	Dihydralazine	3075406	CTD
18	Dipyridamole	9665216	CTD
19	Dobutamine	2722306	CTD
20	Doxorubicin	View details 2536513 2797225 7472599 9505340 9628680 9789703 9869781 10496198 11896119 15214719 15757121 16134825 16220569 16243910 16510915 16761189 17334414 19202217 20005220 25529476 26915917	CTD
21	Enalapril	9838955 18593848	CTD
22	Enoximone	2527935	CTD
23	Ephedrine	15899737	CTD
24	Epinephrine	1389744	CTD
25	Epirubicin	8676653	CTD
26	Fluticasone-Salmeterol Drug Combination	19081299	CTD
27	Furazolidone	1326300 3256424	CTD
28	Furosemide	9838955 18628775	CTD
29	Hydralazine	3799428	CTD
30	Idarubicin	12144690	CTD
31	Imipramine	17100146	CTD
32	Lithium	17100146	CTD
33	Losartan	18593848 18971572	CTD
34	Mercuric Chloride	21984480	CTD
35	Mercury Compounds	10334427	CTD
36	Methamphetamine	1996001 2612079 19330818	CTD
37	Methylphenidate	19554092	CTD
38	Metoprolol	View details 3893793 10147474 11986409 16762803 18628775 19477965	CTD
39	Morphine	18628775	CTD
40	Nifedipine	6241903	CTD
41	Prednisone	11435335	CTD
42	Ramipril	18628775	CTD
43	Resveratrol	25425099	CTD
44	Ribavirin	16462543	CTD
45	Ritodrine	3681864	CTD
46	Selenium	16040888	CTD
47	Sodium Oxybate	15899737	CTD
48	Spironolactone	16275882 18628775	CTD
49	Streptozocin	12198386	CTD
50	Testosterone	25996886	CTD
51	Torsemide	18154949	CTD
52	Tretinoin	12144690	CTD
53	Zidovudine	13130421 17943461	CTD
54	benazepril	8417514	CTD
55	bisphenol A	25996886	CTD
56	candesartan cilexetil	22120037	CTD
57	fasudil	22465603	CTD
58	leonurine	31005592	CTD
59	liposomal amphotericin B	7985716 14657095 15848302	CTD
60	pimobendan	17556660 20428258	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hypertrophic Cardiomyopathy	45.3%
2	Hypertrophic obstructive cardiomyopathy	45.3%
3	Restrictive cardiomyopathy	44.4%
4	Endocardial Fibroelastosis	44.4%
5	Myocarditis	44.4%
6	Endomyocardial Fibrosis	44.4%
7	Carditis	44.4%
8	Myocardial Ischemia	41.4%
9	Cardiac Tamponade	40.9%
10	Endocarditis	40.9%
11	Cardiac Arrest	40.9%
12	Heart failure	40.9%
13	Pericardial effusion	40.9%
14	Pericarditis	40.9%
15	Pneumopericardium	40.9%
16	Cor pulmonale	40.9%
17	Ventricular Outflow Obstruction	40.9%
18	Ventricular Dysfunction	40.9%
19	Pleuropericarditis	40.9%
20	Aortic Valve Stenosis	40%
21	Pulmonary Valve Stenosis	40%
22	Arrhythmogenic Right Ventricular Dysplasia	39.8%
23	Myocardial Reperfusion Injury	37.9%
24	Diabetic Cardiomyopathies	33.3%
25	Cardiomyopathy, Alcoholic	33.1%
26	Left Ventricular Hypertrophy	33.1%
27	Right Ventricular Hypertrophy	33.1%
28	Chagas Cardiomyopathy	32.9%
29	Heart Block	32%
30	Tachycardia	32%
31	Tachyarrhythmia	32%
32	Cardiac Output, High	31%
33	Myocardial Stunning	31%
34	Low Cardiac Output Syndrome	31%
35	Tricuspid Atresia	30.9%
36	Postpericardiotomy Syndrome	30.5%
37	Rheumatic Heart Disease	30.1%
38	Supravalvular aortic stenosis	29.5%
39	Lown-Ganong-Levine Syndrome	29.5%
40	Aortic Valve Insufficiency	26.7%
41	Coronary heart disease	26.7%
42	Heart Rupture, Post-Infarction	26.7%
43	Mitral Valve Insufficiency	26.7%
44	Mitral Valve Stenosis	26.7%
45	Myocardial Infarction	26.7%
46	Pericarditis, Constrictive	26.7%
47	Pulmonary Valve Insufficiency	26.7%
48	Tricuspid Valve Insufficiency	26.7%
49	Tricuspid Valve Stenosis	26.7%
50	Ventricular Dysfunction, Left	26.7%
51	Right Ventricular Dysfunction	26.7%
52	Acute Coronary Syndrome	26.7%
53	Heart Failure, Systolic	26.7%
54	Heart Failure, Diastolic	26.7%
55	Long QT Syndrome	26.5%
56	Sick Sinus Syndrome	25.1%
57	Vascular Diseases	23.8%
58	Adams-Stokes Syndrome	23.5%
59	Atrioventricular Block	23.5%
60	Bundle-Branch Block	23.5%
61	Atrial Premature Complexes	23.5%
62	Sinoatrial Block	23.5%
63	Tachycardia, Paroxysmal	23.5%
64	Supraventricular tachycardia	23.5%
65	Tachycardia, Ventricular	23.5%
66	Wolff-Parkinson-White Syndrome	23.5%
67	Tachycardia, Reciprocating	23.5%
68	Kounis Syndrome	21.6%
69	Aortic coarctation	21.2%
70	Cor Triatriatum	21.2%
71	Coronary Vessel Anomalies	21.2%
72	Patent ductus arteriosus	21.2%
73	Ebstein Anomaly	21.2%
74	Heart Septal Defects	21.2%
75	Tetralogy of Fallot	21.2%
76	Transposition of Great Vessels	21.2%
77	Hypoplastic Left Heart Syndrome	21.2%
78	Angina Pectoris	21.1%
79	Coronary Aneurysm	21.1%
80	Bacterial Endocarditis	20.5%
81	Cardiomyopathies	20.5%
82	Sinus Arrhythmia	20%
83	Atrial Fibrillation	20%
84	Atrial Flutter	20%
85	Cardiomyopathy, Dilated	20%
86	Edema, Cardiac	20%
87	Ventricular Fibrillation	20%
88	Ventricular Flutter	20%
89	Parasystole	20%
90	Paroxysmal atrial fibrillation	20%
91	Bradycardia	20%
92	Sudden Cardiac Death	19.8%
93	Aortic Valve Prolapse	19.8%
94	Tricuspid Valve Prolapse	19.8%
95	Takotsubo Cardiomyopathy	19.8%
96	Coronary Occlusion	19.7%
97	Microvascular Angina	19.7%
98	Coronary Stenosis	19.7%
99	ST segment elevation myocardial infarction	19.7%
100	Coronary Thrombosis	19.6%
101	Coronary Artery Disease	19.6%
102	Carcinoid Heart Disease	19.6%
103	Romano-Ward Syndrome	19.5%
104	Tachycardia, Atrioventricular Nodal Reentry	19.4%
105	Tachycardia, Ectopic Atrial	19.4%
106	Tachycardia, Ectopic Junctional	19.4%
107	Sinus Tachycardia	19.4%
108	Torsades de Pointes	19.4%
109	Accelerated Idioventricular Rhythm	19.4%
110	Pregnancy Complications, Cardiovascular	17.9%
111	Cardiovascular Abnormalities	17.9%
112	Dextrocardia	17.7%
113	Coronary Restenosis	16.3%
114	Dyspnea, Paroxysmal	15.9%
115	Shock, Cardiogenic	15.8%
116	Aortopulmonary Septal Defect	15.6%
117	Double Outlet Right Ventricle	15.6%
118	Endocardial Cushion Defects	15.6%
119	Myocardial bridging	15.6%
120	Aorticopulmonary Septal Defect	15.6%
121	Angina, Unstable	15.6%
122	Cardiomegaly	15.3%
123	Cardiac Hypertrophy	15.3%
124	Sinus Arrest, Cardiac	14.8%
125	Aneurysm	13.6%
126	Angiomatosis	13.6%
127	Aortic Diseases	13.6%
128	Arterial Occlusive Diseases	13.6%
129	Hyperemia	13.6%
130	Hypotension	13.6%
131	Superior Vena Cava Syndrome	13.6%
132	Telangiectasis	13.6%
133	Vasculitis	13.6%
134	Venous Insufficiency	13.6%
135	Peripheral Vascular Diseases	13.6%
136	Embolism and Thrombosis	13.6%
137	Angiodysplasia	13.6%
138	Capillary Leak Syndrome	13.6%
139	Prehypertension	13.6%
140	Aortic Aneurysm	13.3%
141	Aortitis	13.3%
142	Leriche Syndrome	13.3%
143	Noonan Syndrome	13.3%
144	Periphlebitis	13.3%
145	Phlebitis	13.3%
146	Thromboangiitis Obliterans	13.3%
147	Truncus Arteriosus, Persistent	12.9%
148	Angina Pectoris, Variant	12.9%
149	Subacute Bacterial Endocarditis	12.2%
150	Embolism, Amniotic Fluid	12.1%
151	Marfan Syndrome	12%
152	Postphlebitic Syndrome	11.6%
153	Retinal Vein Occlusion	11.5%
154	Arteriovenous fistula	11.5%
155	Thrombophlebitis	11.1%
156	Kearns-Sayre syndrome	10.8%
157	Vascular System Injuries	10.7%
158	Malignant Atrophic Papulosis	10.7%
159	Shwartzman Phenomenon	10.6%
160	May-Thurner Syndrome	10.6%
161	Compartment syndromes	10.3%
162	Hepatic Veno-Occlusive Disease	10.3%
163	Peliosis Hepatis	10.3%
164	Varicocele	10.3%
165	Blue Toe Syndrome	10.3%
166	Cerebrovascular Disorders	10.2%
167	Diabetic Angiopathies	10.2%
168	Reperfusion Injury	10.2%
169	Splenic Infarction	10.2%
170	Cerebrovascular Insufficiency	10.2%
171	Vascular Neoplasms	10.2%
172	Spinal Cord Vascular Diseases	10.2%
173	Vasoplegia	10.2%
174	Hemorrhoids	10.1%
175	Thoracic Outlet Syndrome	10.1%
176	Aortic Rupture	9.9%
177	Aortic Aneurysm, Abdominal	9.8%
178	Aortic Aneurysm, Thoracic	9.8%
179	Intracranial Embolism and Thrombosis	9.2%
180	Carotid Artery Thrombosis	9.2%
181	Carotid Stenosis	9.2%
182	Intracranial Aneurysm	9.2%
183	Aneurysm, Dissecting	8.9%
184	Arteriosclerosis	8.9%
185	Arteritis	8.9%
186	Embolism	8.9%
187	Erythromelalgia	8.9%
188	Fibromuscular Dysplasia	8.9%
189	Malignant Hypertension	8.9%
190	Raynaud Disease	8.9%
191	Thromboembolism	8.9%
192	Thrombosis	8.9%
193	Essential Hypertension	8.9%
194	Aneurysm, Ruptured	8.9%
195	Iliac Aneurysm	8.9%
196	Pulmonary artery stenosis	8.9%
197	White Coat Hypertension	8.9%
198	Systemic Vasculitis	8.9%
199	Embolus	8.9%
200	Moyamoya Disease	8.8%
201	Scimitar Syndrome	8.5%
202	Hand-Arm Vibration Syndrome	8.5%
203	Optic Neuropathy, Ischemic	8.2%
204	Williams Syndrome	8.2%
205	Anterior Ischemic Optic Neuropathy	8.2%
206	Mesenteric vascular insufficiency	8.2%
207	Angioedema	8%
208	Colitis, Ischemic	8%
209	Polyarteritis Nodosa	7.9%
210	Takayasu Arteritis	7.9%
211	Intracranial Arteriosclerosis	7.8%
212	Cerebral Atherosclerosis	7.8%
213	Cerebral Arteriosclerosis	7.8%
214	Vasculitis, Central Nervous System	7.7%
215	Cerebral Thrombosis	7.1%
216	Intracranial Embolism	7.1%
217	Intracranial Thrombosis	7.1%
218	Turner Syndrome	6.9%
219	Retinal Artery Occlusion	6.8%
220	Retinal Vasculitis	6.8%
221	Hypertensive Retinopathy	6.8%
222	Anterior Compartment Syndrome	6.7%
223	Vasculitis, Leukocytoclastic, Cutaneous	6.7%
224	Gastric Antral Vascular Ectasia	6.7%
225	Abdominal Compartment Syndrome	6.7%
226	Carotid Artery Diseases	6.6%
227	Brain Ischemia	6.6%
228	Ectopia Cordis	6.6%
229	Hypotension, Orthostatic	6.6%
230	Cerebrovascular accident	6.6%
231	Varicose Ulcer	6.6%
232	Vasospasm, Intracranial	6.6%
233	Spinal Cord Ischemia	6.6%
234	Intracranial Arterial Diseases	6.6%
235	Primary Graft Dysfunction	6.6%
236	Single umbilical artery	6.6%
237	Post-Exercise Hypotension	6.6%
238	Arteriosclerosis Obliterans	6.6%
239	Atherosclerosis	6.6%
240	Air Embolism	6.6%
241	Endarteritis	6.6%
242	Venous Thrombosis	6.6%
243	Deep Vein Thrombosis	6.6%
244	Venous Thromboembolism	6.6%
245	Giant Cell Arteritis	6.5%
246	Temporal Arteritis	6.5%
247	Brain Infarction	6.5%
248	Sinus Thrombosis, Intracranial	6.1%
249	Lemierre Syndrome	6%
250	Kartagener Syndrome	5.7%
251	Subarachnoid Hemorrhage, Traumatic	5.7%
252	Carotid Artery, Internal, Dissection	5.7%
253	CREST Syndrome	5.7%
254	Cavernous Sinus Thrombosis	5.6%
255	Sagittal Sinus Thrombosis	5.6%
256	Vertebral Artery Dissection	5.6%
257	Infarction, Middle Cerebral Artery	5.6%
258	Infarction, Anterior Cerebral Artery	5.6%
259	Infarction, Posterior Cerebral Artery	5.6%
260	Mesenteric Vascular Occlusion	5.4%
261	Mucocutaneous Lymph Node Syndrome	5.4%
262	Diabetic Retinopathy	5.4%
263	Sturge-Weber Syndrome	5.4%
264	Cerebral Infarction	5.4%
265	Brain Stem Infarctions	5.4%
266	Livedo Reticularis	5.3%
267	Renal hypertension	5.3%
268	Renal Artery Obstruction	5.3%
269	Renal Artery Stenosis	5.3%
270	Hemangioma, Cavernous	5.3%
271	Basal Ganglia Cerebrovascular Disease	5.3%
272	Vascular Headaches	5.2%
273	Scurvy	5.2%
274	Intermittent Claudication	5%
275	Pulmonary Embolism	5%
276	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5%
277	No-Reflow Phenomenon	5%
278	Cerebral Arterial Diseases	4.9%
279	Vertebrobasilar Insufficiency	4.9%
280	Carotid Artery Injuries	4.9%
281	Anterior Spinal Artery Syndrome	4.9%
282	Basilar Artery Stenosis	4.9%
283	Vertebral Artery Stenosis	4.9%
284	Intracranial Hemorrhage, Hypertensive	4.9%
285	Transient Cerebral Ischemia	4.9%
286	Lateral Medullary Syndrome	4.8%
287	Dural Arteriovenous Fistula	4.5%
288	Ischemic contracture	4.4%
289	Basal Ganglia Hemorrhage	4.4%
290	Angioedemas, Hereditary	4.4%
291	Cryoglobulinemia	4.4%
292	Leukomalacia, Periventricular	4.4%
293	Diabetic Foot	4.4%
294	Hepatic Vein Thrombosis	4.2%
295	Budd-Chiari Syndrome	4.2%
296	Pulmonary Infarction	4.1%
297	Subclavian Steal Syndrome	4.1%
298	Hypertension, Renovascular	3.9%
299	Subarachnoid Hemorrhage	3.9%
300	Hypoxia-Ischemia, Brain	3.9%
301	Cerebral Hemorrhage	3.9%
302	Hereditary Angioedema Type III	3.9%
303	Hereditary Angioedema Types I and II	3.9%
304	Putaminal Hemorrhage	3.8%
305	Shy-Drager Syndrome	3.7%
306	Purpura, Hyperglobulinemic	3.7%
307	Dementia, Vascular	3.6%
308	Behcet Syndrome	3.3%
309	Waldenstrom Macroglobulinemia	3.3%
310	Multiple Myeloma	3.3%
311	Granulomatosis with polyangiitis	3.3%
312	Pituitary Apoplexy	3.3%
313	Cerebral Amyloid Angiopathy	3.2%
314	Lupus Vasculitis, Central Nervous System	3%
315	Ataxia Telangiectasia	3%
316	Pseudoxanthoma Elasticum	3%
317	Rheumatoid Vasculitis	2.8%
318	Hematoma, Subdural	2%
319	Hematoma, Epidural, Cranial	2%
320	Hematoma, Subdural, Intracranial	1.8%
321	Hematoma, Subdural, Chronic	1.8%
322	Hematoma, Subdural, Acute	1.8%
323	Brain Hemorrhage, Traumatic	1.8%
324	MELAS Syndrome	1.8%
325	Fabry Disease	1.4%

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