MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thromboangiitis Obliterans

(UMLS:C0040021)

Definition:: A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
UMLS ID:: C0040021
MeSH ID:: D013919

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.137.870|C14.907.940.905

Synonym(s)

Thromboangiitis Obliterans

BUERGER DISEASE

Buerger

Buerger Disease

Buerger's Disease

Buerger's disease

Disease;Buergers

GANGRENE, PRESENILE

Presenile gangrene

10.

TAO

11.

Thrombo Angiitis Obliterans

12.

Thromboangiitis obliterans

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 4		US FAERS
2	Varenicline	FAERS: 2		US FAERS
3	Atomoxetine Hydrochloride	FAERS: 1		US FAERS
4	Atorvastatin	FAERS: 1		US FAERS
5	Bosentan	FAERS: 1		US FAERS
6	Cilostazol	FAERS: 1		US FAERS
7	NuvaRing	FAERS: 1		US FAERS
8	Raloxifene Hydrochloride	FAERS: 1		US FAERS
9	Rivastigmine	FAERS: 1		US FAERS
10	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
11	apixaban	FAERS: 1		US FAERS
12	Alprostadil		11598405	CTD
13	Cocaine		10888980 12105344	CTD
14	Glatiramer Acetate			OFFSIDES
15	Lamotrigine			OFFSIDES
16	Leflunomide			OFFSIDES
17	Nicotine		12474585	CTD
18	Norinyl		7034891	CTD
19	Raloxifene Hydrochloride			OFFSIDES
20	Thiamine			OFFSIDES
21	abacavir			OFFSIDES
22	alpha-Tocopherol			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Aortitis	53.3%
2	Leriche Syndrome	53.3%
3	Periphlebitis	53.3%
4	Phlebitis	53.3%
5	Malignant Atrophic Papulosis	53.3%
6	Arteriosclerosis	44.4%
7	Arteritis	44.4%
8	Fibromuscular Dysplasia	44.4%
9	Pulmonary artery stenosis	44.4%
10	Systemic Vasculitis	44.4%
11	Shwartzman Phenomenon	42.4%
12	Myocardial Ischemia	41.4%
13	Thrombophlebitis	41%
14	Aneurysm	40.9%
15	Angiomatosis	40.9%
16	Aortic Diseases	40.9%
17	Hyperemia	40.9%
18	Hypotension	40.9%
19	Superior Vena Cava Syndrome	40.9%
20	Telangiectasis	40.9%
21	Venous Insufficiency	40.9%
22	Peripheral Vascular Diseases	40.9%
23	Embolism and Thrombosis	40.9%
24	Angiodysplasia	40.9%
25	Capillary Leak Syndrome	40.9%
26	Prehypertension	40.9%
27	Aortic Aneurysm	40%
28	Polyarteritis Nodosa	39.5%
29	Carotid Stenosis	38%
30	Coronary Artery Disease	35.3%
31	Postphlebitic Syndrome	34.7%
32	Retinal Vein Occlusion	34.6%
33	Retinal Artery Occlusion	33.9%
34	Retinal Vasculitis	33.9%
35	Moyamoya Disease	33.8%
36	Vasculitis, Leukocytoclastic, Cutaneous	33.3%
37	Arteriosclerosis Obliterans	33%
38	Atherosclerosis	33%
39	Endarteritis	33%
40	Vascular System Injuries	32.1%
41	Coronary Aneurysm	31.6%
42	Takayasu Arteritis	31.6%
43	Intracranial Arteriosclerosis	31.3%
44	Cerebral Atherosclerosis	31.3%
45	Cerebral Arteriosclerosis	31.3%
46	Compartment syndromes	31%
47	Hepatic Veno-Occlusive Disease	31%
48	Peliosis Hepatis	31%
49	Varicocele	31%
50	Blue Toe Syndrome	30.8%
51	Vasculitis, Central Nervous System	30.6%
52	Cerebrovascular Disorders	30.5%
53	Diabetic Angiopathies	30.5%
54	Reperfusion Injury	30.5%
55	Splenic Infarction	30.5%
56	Cerebrovascular Insufficiency	30.5%
57	Vascular Neoplasms	30.5%
58	Spinal Cord Vascular Diseases	30.5%
59	Vasoplegia	30.5%
60	Myocardial Reperfusion Injury	30.3%
61	Hemorrhoids	30.3%
62	Thoracic Outlet Syndrome	30.3%
63	Aortic Rupture	29.8%
64	Aortic Aneurysm, Abdominal	29.5%
65	Aortic Aneurysm, Thoracic	29.5%
66	Giant Cell Arteritis	28.3%
67	Temporal Arteritis	28.3%
68	Intracranial Embolism and Thrombosis	27.6%
69	Carotid Artery Thrombosis	27.6%
70	Intracranial Aneurysm	27.5%
71	Coronary Thrombosis	27.5%
72	Mesenteric Vascular Occlusion	27%
73	Mucocutaneous Lymph Node Syndrome	27%
74	Aneurysm, Dissecting	26.7%
75	Coronary heart disease	26.7%
76	Embolism	26.7%
77	Erythromelalgia	26.7%
78	Malignant Hypertension	26.7%
79	Myocardial Infarction	26.7%
80	Raynaud Disease	26.7%
81	Thromboembolism	26.7%
82	Thrombosis	26.7%
83	Essential Hypertension	26.7%
84	Aneurysm, Ruptured	26.7%
85	Iliac Aneurysm	26.7%
86	White Coat Hypertension	26.7%
87	Acute Coronary Syndrome	26.7%
88	Embolus	26.7%
89	Renal Artery Obstruction	26.5%
90	Renal Artery Stenosis	26.5%
91	Hand-Arm Vibration Syndrome	25.4%
92	Intermittent Claudication	25.2%
93	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	25.2%
94	Optic Neuropathy, Ischemic	24.7%
95	Anterior Ischemic Optic Neuropathy	24.7%
96	Mesenteric vascular insufficiency	24.7%
97	Arteriovenous fistula	24.5%
98	Angioedema	24%
99	Colitis, Ischemic	23.9%
100	Heart Diseases	23.8%
101	Lemierre Syndrome	22.1%
102	Kounis Syndrome	21.6%
103	Cerebral Thrombosis	21.4%
104	Intracranial Embolism	21.4%
105	Intracranial Thrombosis	21.4%
106	May-Thurner Syndrome	21.2%
107	Angina Pectoris	21.1%
108	Arterial Occlusive Diseases	20.5%
109	Vasculitis	20.5%
110	Hypertensive Retinopathy	20.3%
111	Embolism, Amniotic Fluid	20.1%
112	Anterior Compartment Syndrome	20%
113	Thromboangiitis Obliterans	20%
114	Gastric Antral Vascular Ectasia	20%
115	Abdominal Compartment Syndrome	20%
116	Carotid Artery Diseases	19.8%
117	Brain Ischemia	19.8%
118	Hypotension, Orthostatic	19.8%
119	Cerebrovascular accident	19.8%
120	Varicose Ulcer	19.8%
121	Vasospasm, Intracranial	19.8%
122	Spinal Cord Ischemia	19.8%
123	Intracranial Arterial Diseases	19.8%
124	Primary Graft Dysfunction	19.8%
125	Post-Exercise Hypotension	19.8%
126	Air Embolism	19.8%
127	Venous Thrombosis	19.8%
128	Deep Vein Thrombosis	19.8%
129	Venous Thromboembolism	19.8%
130	Coronary Occlusion	19.7%
131	Microvascular Angina	19.7%
132	Coronary Stenosis	19.7%
133	ST segment elevation myocardial infarction	19.7%
134	Brain Infarction	19.5%
135	Scimitar Syndrome	18.7%
136	Sinus Thrombosis, Intracranial	18.4%
137	Pregnancy Complications, Cardiovascular	17.9%
138	Cardiovascular Abnormalities	17.9%
139	Subarachnoid Hemorrhage, Traumatic	17.2%
140	Carotid Artery, Internal, Dissection	17.2%
141	CREST Syndrome	17.1%
142	Cavernous Sinus Thrombosis	16.9%
143	Sagittal Sinus Thrombosis	16.9%
144	Vertebral Artery Dissection	16.9%
145	Infarction, Middle Cerebral Artery	16.8%
146	Infarction, Anterior Cerebral Artery	16.8%
147	Infarction, Posterior Cerebral Artery	16.8%
148	Behcet Syndrome	16.6%
149	Granulomatosis with polyangiitis	16.5%
150	Coronary Restenosis	16.3%
151	Diabetic Retinopathy	16.1%
152	Sturge-Weber Syndrome	16.1%
153	Cerebral Infarction	16.1%
154	Brain Stem Infarctions	16.1%
155	Livedo Reticularis	16%
156	Renal hypertension	15.9%
157	Hemangioma, Cavernous	15.8%
158	Shock, Cardiogenic	15.8%
159	Basal Ganglia Cerebrovascular Disease	15.8%
160	Vascular Headaches	15.7%
161	Scurvy	15.7%
162	Angina, Unstable	15.6%
163	Pulmonary Embolism	15.1%
164	No-Reflow Phenomenon	14.9%
165	Cerebral Arterial Diseases	14.7%
166	Vertebrobasilar Insufficiency	14.7%
167	Carotid Artery Injuries	14.7%
168	Anterior Spinal Artery Syndrome	14.7%
169	Basilar Artery Stenosis	14.7%
170	Vertebral Artery Stenosis	14.7%
171	Intracranial Hemorrhage, Hypertensive	14.7%
172	Transient Cerebral Ischemia	14.7%
173	Lateral Medullary Syndrome	14.4%
174	Dementia, Vascular	14.4%
175	Rheumatoid Vasculitis	14.1%
176	Cardiac Tamponade	13.6%
177	Endocarditis	13.6%
178	Cardiac Arrest	13.6%
179	Heart failure	13.6%
180	Pericardial effusion	13.6%
181	Pericarditis	13.6%
182	Pneumopericardium	13.6%
183	Cor pulmonale	13.6%
184	Ventricular Outflow Obstruction	13.6%
185	Ventricular Dysfunction	13.6%
186	Cardiomyopathies	13.6%
187	Pleuropericarditis	13.6%
188	Aortic Valve Stenosis	13.3%
189	Cardiomyopathy, Dilated	13.3%
190	Pulmonary Valve Stenosis	13.3%
191	Ischemic contracture	13.3%
192	Basal Ganglia Hemorrhage	13.3%
193	Angioedemas, Hereditary	13.3%
194	Tricuspid Atresia	13.3%
195	Arrhythmogenic Right Ventricular Dysplasia	13.3%
196	Cryoglobulinemia	13.2%
197	Leukomalacia, Periventricular	13.2%
198	Diabetic Foot	13.1%
199	Angina Pectoris, Variant	12.9%
200	Hepatic Vein Thrombosis	12.6%
201	Budd-Chiari Syndrome	12.6%
202	Pulmonary Infarction	12.3%
203	Subclavian Steal Syndrome	12.2%
204	Lupus Vasculitis, Central Nervous System	12%
205	Hypertension, Renovascular	11.7%
206	Subarachnoid Hemorrhage	11.7%
207	Hypoxia-Ischemia, Brain	11.7%
208	Cerebral Hemorrhage	11.7%
209	Hereditary Angioedema Type III	11.7%
210	Hereditary Angioedema Types I and II	11.7%
211	Putaminal Hemorrhage	11.4%
212	Bacterial Endocarditis	11.4%
213	Shy-Drager Syndrome	11.2%
214	Purpura, Hyperglobulinemic	11.2%
215	Hypertrophic Cardiomyopathy	10.7%
216	Hypertrophic obstructive cardiomyopathy	10.7%
217	Heart Block	10.7%
218	Tachycardia	10.7%
219	Tachyarrhythmia	10.7%
220	Aortic coarctation	10.6%
221	Cor Triatriatum	10.6%
222	Coronary Vessel Anomalies	10.6%
223	Patent ductus arteriosus	10.6%
224	Ebstein Anomaly	10.6%
225	Heart Septal Defects	10.6%
226	Tetralogy of Fallot	10.6%
227	Transposition of Great Vessels	10.6%
228	Hypoplastic Left Heart Syndrome	10.6%
229	Cardiac Output, High	10.3%
230	Myocardial Stunning	10.3%
231	Low Cardiac Output Syndrome	10.3%
232	Cardiomegaly	10.2%
233	Postpericardiotomy Syndrome	10.2%
234	Cardiac Hypertrophy	10.2%
235	Rheumatic Heart Disease	10%
236	Waldenstrom Macroglobulinemia	9.9%
237	Multiple Myeloma	9.9%
238	Pituitary Apoplexy	9.9%
239	Supravalvular aortic stenosis	9.8%
240	Lown-Ganong-Levine Syndrome	9.8%
241	Cerebral Amyloid Angiopathy	9.7%
242	Ataxia Telangiectasia	9%
243	Pseudoxanthoma Elasticum	8.9%
244	Aortic Valve Insufficiency	8.9%
245	Restrictive cardiomyopathy	8.9%
246	Endocardial Fibroelastosis	8.9%
247	Heart Rupture, Post-Infarction	8.9%
248	Mitral Valve Insufficiency	8.9%
249	Mitral Valve Stenosis	8.9%
250	Myocarditis	8.9%
251	Pericarditis, Constrictive	8.9%
252	Pulmonary Valve Insufficiency	8.9%
253	Tricuspid Valve Insufficiency	8.9%
254	Tricuspid Valve Stenosis	8.9%
255	Ventricular Dysfunction, Left	8.9%
256	Right Ventricular Dysfunction	8.9%
257	Endomyocardial Fibrosis	8.9%
258	Carditis	8.9%
259	Heart Failure, Systolic	8.9%
260	Heart Failure, Diastolic	8.9%
261	Dextrocardia	8.8%
262	Long QT Syndrome	8.8%
263	Sick Sinus Syndrome	8.4%
264	Adams-Stokes Syndrome	7.8%
265	Atrioventricular Block	7.8%
266	Bundle-Branch Block	7.8%
267	Atrial Premature Complexes	7.8%
268	Sinoatrial Block	7.8%
269	Tachycardia, Paroxysmal	7.8%
270	Supraventricular tachycardia	7.8%
271	Tachycardia, Ventricular	7.8%
272	Wolff-Parkinson-White Syndrome	7.8%
273	Tachycardia, Reciprocating	7.8%
274	Aortopulmonary Septal Defect	7.8%
275	Double Outlet Right Ventricle	7.8%
276	Endocardial Cushion Defects	7.8%
277	Myocardial bridging	7.8%
278	Aorticopulmonary Septal Defect	7.8%
279	Sinus Arrhythmia	6.7%
280	Atrial Fibrillation	6.7%
281	Atrial Flutter	6.7%
282	Edema, Cardiac	6.7%
283	Noonan Syndrome	6.7%
284	Ventricular Fibrillation	6.7%
285	Ventricular Flutter	6.7%
286	Parasystole	6.7%
287	Paroxysmal atrial fibrillation	6.7%
288	Bradycardia	6.7%
289	Diabetic Cardiomyopathies	6.7%
290	Cardiomyopathy, Alcoholic	6.6%
291	Ectopia Cordis	6.6%
292	Sudden Cardiac Death	6.6%
293	Left Ventricular Hypertrophy	6.6%
294	Right Ventricular Hypertrophy	6.6%
295	Single umbilical artery	6.6%
296	Aortic Valve Prolapse	6.6%
297	Tricuspid Valve Prolapse	6.6%
298	Takotsubo Cardiomyopathy	6.6%
299	Chagas Cardiomyopathy	6.6%
300	Subacute Bacterial Endocarditis	6.6%
301	Carcinoid Heart Disease	6.5%
302	Romano-Ward Syndrome	6.5%
303	Tachycardia, Atrioventricular Nodal Reentry	6.5%
304	Tachycardia, Ectopic Atrial	6.5%
305	Tachycardia, Ectopic Junctional	6.5%
306	Sinus Tachycardia	6.5%
307	Torsades de Pointes	6.5%
308	Accelerated Idioventricular Rhythm	6.5%
309	Truncus Arteriosus, Persistent	6.5%
310	Hematoma, Subdural	6.1%
311	Hematoma, Epidural, Cranial	6.1%
312	Marfan Syndrome	6%
313	Hematoma, Subdural, Intracranial	5.4%
314	Hematoma, Subdural, Chronic	5.4%
315	Hematoma, Subdural, Acute	5.4%
316	Brain Hemorrhage, Traumatic	5.4%
317	Dyspnea, Paroxysmal	5.3%
318	MELAS Syndrome	5.3%
319	Sinus Arrest, Cardiac	4.9%
320	Dural Arteriovenous Fistula	4.5%
321	Fabry Disease	4.1%
322	Turner Syndrome	3.4%
323	Kartagener Syndrome	2.9%
324	Williams Syndrome	2.7%
325	Kearns-Sayre syndrome	2.2%

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