MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lissencephaly

(UMLS:C0266463)

Definition:: A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
UMLS ID:: C0266463
MeSH ID:: D054082

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.507.450.499

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.507.450.499

Synonym(s)

Lissencephaly

Fewer or absent grooves in brain

Lissencephaly pachygyria

lissencephaly

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Lamotrigine	FAERS: 3	US FAERS
2	Valproic Acid	FAERS: 3	US FAERS
3	apixaban	FAERS: 3	US FAERS
4	Citalopram	FAERS: 2	US FAERS
5	Fluoxetine	FAERS: 2	US FAERS
6	Isotretinoin	FAERS: 2	US FAERS
7	Vigabatrin	FAERS: 2	OFFSIDES US FAERS
8	dolutegravir	FAERS: 2	US FAERS
9	Bosentan	FAERS: 1	US FAERS
10	Fingolimod Hydrochloride	FAERS: 1	US FAERS
11	Maprotiline		OFFSIDES
12	etizolam		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Periventricular Nodular Heterotopia	48.8%
2	Classical Lissencephalies and Subcortical Band Heterotopias	28.5%
3	Hydranencephaly	27%
4	Neural Tube Defects	27%
5	Tethered Cord Syndrome	27%
6	Iniencephaly	27%
7	Craniorachischisis	27%
8	Exencephaly	27%
9	Septo-Optic Dysplasia	27%
10	Polymicrogyria	23.2%
11	Schizencephaly	23.2%
12	Dural Arteriovenous Fistula	20.4%
13	Dandy-Walker Syndrome	20%
14	Central Nervous System Cysts	19.6%
15	Microcephaly	18%
16	Macrocephaly	18%
17	Anencephaly	17.6%
18	Porencephaly	17.1%
19	Aicardi's syndrome	15.9%
20	Meningomyelocele	15.8%
21	Spina Bifida	15.8%
22	Holoprosencephaly	15.1%
23	Abnormalities, Drug-Induced	14.9%
24	Situs Inversus	14.9%
25	Tuberous Sclerosis	12.8%
26	Meningocele	12.7%
27	Encephalocele	12.7%
28	Smith-Magenis syndrome	12.5%
29	Eye Abnormalities	11.8%
30	Cardiovascular Abnormalities	11.8%
31	Beckwith-Wiedemann Syndrome	11.5%
32	Wolf-Hirschhorn Syndrome	11.5%
33	Skin Abnormalities	11.4%
34	Lymphatic Abnormalities	11.4%
35	Congenital Microtia	11.4%
36	Charcot-Marie-Tooth Disease	11.3%
37	Congenital diaphragmatic hernia	11.1%
38	Cri-du-Chat Syndrome	10.6%
39	Down Syndrome	10.6%
40	Trisomy 21	10.6%
41	Cranial nerve diseases	10.4%
42	Demyelinating Diseases	10.4%
43	Demyelination	10.4%
44	Neuromuscular Diseases	10.4%
45	Chronobiology Disorders	10.4%
46	Dermal Sinus	10.4%
47	Spina Bifida Cystica	10.4%
48	Spina Bifida Occulta	10.4%
49	Genetic Diseases, Inborn	9.8%
50	Alstrom Syndrome	9.7%
51	Urogenital Abnormalities	9.5%
52	Prader-Willi Syndrome	9.1%
53	Rubinstein-Taybi Syndrome	8.7%
54	Motor Neuron Disease	8.4%
55	Mobius Syndrome	8.3%
56	Ectodermal Dysplasia	8.2%
57	Aplasia Cutis Congenita	8.2%
58	Trauma, Nervous System	8.1%
59	Prune Belly Syndrome	8.1%
60	Twins, Conjoined	8.1%
61	Waardenburg Syndrome	8.1%
62	CHARGE Syndrome	8%
63	Nervous System Neoplasms	7.9%
64	Neurologic Manifestations	7.9%
65	Neurotoxicity Syndromes	7.9%
66	Fetal Diseases	7.4%
67	Stiff-Person Syndrome	7.3%
68	Refsum Disease	7.2%
69	Multiple System Atrophy	7.2%
70	Ocular Motility Disorders	7%
71	Cyclophoria	7%
72	Nail-Patella Syndrome	6.7%
73	Restless Legs Syndrome	6.7%
74	Polyradiculoneuropathy	6.7%
75	Polyradiculoneuritis	6.7%
76	Xeroderma	6.6%
77	Encephalomyelitis	6.6%
78	Prion Diseases	6.6%
79	Autonomic Dysreflexia	6.6%
80	Complex Regional Pain Syndromes	6.6%
81	Maxillofacial Abnormalities	6.6%
82	Dextrocardia	6.5%
83	Williams Syndrome	6.5%
84	Sleep Wake Disorders	6.4%
85	Cockayne Syndrome	6.4%
86	Abnormalities, Radiation-Induced	6.3%
87	Anophthalmos	6.2%
88	Anus, Imperforate	6.2%
89	Microphthalmos	6.2%
90	Limb Deformities, Congenital	6.2%
91	Craniofacial Abnormalities	6.2%
92	Myasthenic Syndromes, Congenital	6.2%
93	Anorectal Malformations	6.2%
94	Subacute Combined Degeneration	6.2%
95	Bloom Syndrome	6.1%
96	Marfan Syndrome	6.1%
97	Spinal Muscular Atrophy	5.9%
98	Progressive Muscular Atrophy	5.9%
99	Marchiafava-Bignami Disease	5.8%
100	Kartagener Syndrome	5.7%
101	Amyotrophic Lateral Sclerosis	5.6%
102	Ophthalmoplegic Migraine	5.6%
103	Parkinson Disease	5.6%
104	Spinal Cord Injuries	5.5%
105	Brain Diseases	5.5%
106	Dysautonomia	5.5%
107	Meningitis	5.5%
108	Movement Disorders	5.5%
109	Pachymeningitis	5.5%
110	Spinal Cord Diseases	5.5%
111	Vagus Nerve Disorder	5.5%
112	Glossopharyngeal Neuralgia	5.5%
113	Abducens Nerve Diseases	5.5%
114	Heavy Metal Poisoning, Nervous System	5.5%
115	Neuromuscular Junction Diseases	5.5%
116	Tauopathies	5.5%
117	Trochlear Nerve Diseases	5.5%
118	Peripheral Nervous System Diseases	5.5%
119	Meningoencephalitis	5.4%
120	Polycystic Kidney Diseases	5.4%
121	Peripheral Nerve Injuries	5.4%
122	Myasthenia Gravis	5.3%
123	Asterixis	5.3%
124	Ballismus	5.3%
125	Cystic Fibrosis	5.2%
126	Dystonia Musculorum Deformans	5.1%
127	POEMS Syndrome	5.1%
128	Scimitar Syndrome	5.1%
129	Blepharophimosis	5.1%
130	Laryngostenosis	5.1%
131	Mouth Abnormalities	5.1%
132	Esophageal Atresia	5%
133	Intestinal Atresia	5%
134	Horseshoe Kidney	5%
135	Pectus excavatum	5%
136	Abdominal Cramps	5%
137	Amniotic Band Syndrome	5%
138	Asphyxia Neonatorum	5%
139	Infant, Premature, Diseases	5%
140	Infantile Colic	5%
141	Klippel-Feil Syndrome	5%
142	Gastroschisis	5%
143	Synostosis	5%
144	Acrodermatitis	4.9%
145	Lymphangiectasis, Intestinal	4.9%
146	Gianotti-Crosti Syndrome	4.9%
147	Lewy Body Disease	4.9%
148	Pneumocephalus	4.9%
149	Poliomyelitis	4.9%
150	Myelitis	4.9%
151	Progressive bulbar palsy	4.9%
152	Bulbar palsy	4.9%
153	Guillain-Barre Syndrome	4.9%
154	Retinal Dysplasia	4.8%
155	Fragile X Syndrome	4.8%
156	Aniridia	4.8%
157	Epidermolysis Bullosa	4.7%
158	Chronic Fatigue Syndrome	4.6%
159	Neuroleptic Malignant Syndrome	4.6%
160	Myelinolysis, Central Pontine	4.6%
161	Sleep Disorders, Circadian Rhythm	4.6%
162	Striatonigral Degeneration	4.6%
163	Lambert-Eaton Myasthenic Syndrome	4.6%
164	Causalgia	4.5%
165	Ataxia Telangiectasia	4.4%
166	Botulism	4.4%
167	Central Nervous System Infection	4.4%
168	Myopathy	4.4%
169	Optic Neuropathy	4.4%
170	Meconium Aspiration Syndrome	4.4%
171	Epidural Abscess	4.3%
172	Olfactory Nerve Injuries	4.3%
173	Progressive supranuclear palsy	4.3%
174	Muscular Dystrophy	4.3%
175	Congenital nystagmus	4.3%
176	Arthrogryposis	4.2%
177	Choanal Atresia	4.2%
178	Tracheobronchomegaly	4.2%
179	Laryngocele	4.2%
180	Smith-Lemli-Opitz Syndrome	4.2%
181	Myelitis, Transverse	4.2%
182	Facial Nerve Diseases	4.2%
183	Craniocerebral Trauma	4.2%
184	Parasomnia	4.2%
185	Dyssomnias	4.2%
186	MPTP Poisoning	4.2%
187	Choledochal Cyst	4.2%
188	Hermaphroditism	4.2%
189	Disorders of Sex Development	4.2%
190	Craniosynostosis	4.2%
191	Myotonic Dystrophy	4.2%
192	Syndactyly	4.2%
193	Brachycephaly	4.2%
194	Lafora Disease	4.2%
195	Unverricht-Lundborg Syndrome	4.2%
196	Dyskinesia, Drug-Induced	4.2%
197	Cryptorchidism	4.2%
198	Hypospadias	4.2%
199	Vestibulocochlear Nerve Diseases	4.1%
200	Decerebrate State	4.1%
201	Hemiparesis	4.1%
202	Meningism	4.1%
203	Paresis	4.1%
204	Seizures	4.1%
205	Sensation Disorders	4.1%
206	Central Nervous System Neoplasms	4.1%
207	Complex partial seizures	4.1%
208	Monoparesis	4.1%
209	Neurogenic Inflammation	4.1%
210	Gait Disorders, Neurologic	4.1%
211	Neuromuscular Manifestations	4.1%
212	Sweating, Gustatory	4.1%
213	Auriculotemporal Syndrome	4.1%
214	Leukoencephalitis, Acute Hemorrhagic	4.1%
215	Myotonia Congenita	4.1%
216	Primary Ciliary Dyskinesia	4.1%
217	Encephalomyelitis, Acute Disseminated	4.1%
218	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
219	Reflex Sympathetic Dystrophy	4%
220	Subdural Effusion	4%
221	Parkinsonian Disorders	4%
222	Nocturnal Myoclonus Syndrome	4%
223	Opsoclonus-Myoclonus Syndrome	4%
224	Ichthyosis, X-Linked	4%
225	Huntington Disease	4%
226	Miller Fisher Syndrome	4%
227	Canavan Disease	3.9%
228	Alexander Disease	3.9%
229	Shy-Drager Syndrome	3.9%
230	Brain Injuries	3.9%
231	Neoplastic Syndromes, Hereditary	3.9%
232	Toxoplasmosis, Congenital	3.9%
233	Brain Neoplasms	3.9%
234	Multiple Sclerosis	3.9%
235	Spinal Cord Neoplasms	3.9%
236	Neuromyelitis Optica	3.9%
237	Horner Syndrome	3.8%
238	Akathisia, Drug-Induced	3.8%
239	Hepatolenticular Degeneration	3.8%
240	Anemia, Neonatal	3.7%
241	Multiple Epiphyseal Dysplasia	3.7%
242	Osteochondrodysplasias	3.7%
243	Pelger-Huet Anomaly	3.7%
244	Persistent Fetal Circulation Syndrome	3.7%
245	Werner Syndrome	3.7%
246	Facial Nerve Injuries	3.7%
247	Noonan Syndrome	3.7%
248	Umbilical hernia	3.7%
249	Pseudoxanthoma Elasticum	3.7%
250	Amelia	3.6%
251	Arachnodactyly	3.6%
252	Ectopia Cordis	3.6%
253	Ectromelia	3.6%
254	Hemimelia	3.6%
255	Phocomelia	3.6%
256	Sirenomelia	3.6%
257	Polydactyly	3.6%
258	Brachydactyly	3.6%
259	Plagiocephaly	3.6%
260	Lower Extremity Deformities, Congenital	3.6%
261	Upper Extremity Deformities, Congenital	3.6%
262	Single umbilical artery	3.6%
263	Laryngomalacia	3.6%
264	Pectus carinatum	3.6%
265	Bladder Exstrophy	3.5%
266	Epispadias	3.5%
267	Leukomalacia, Periventricular	3.5%
268	Multicystic Dysplastic Kidney	3.5%
269	Muscular Dystrophy, Duchenne	3.5%
270	Pupil Disorders	3.5%
271	Neurobehavioral Manifestations	3.5%
272	Leukoencephalopathy, Progressive Multifocal	3.4%
273	Paraneoplastic Encephalomyelitis	3.4%
274	Xeroderma Pigmentosum	3.3%
275	Uveomeningoencephalitic Syndrome	3.3%
276	Vasculitis, Central Nervous System	3.3%
277	Brain Abscess	3.3%
278	Ophthalmoplegia	3.3%
279	External Ophthalmoplegia	3.3%
280	Scrapie	3.3%
281	Sturge-Weber Syndrome	3.3%
282	Vertigo	3.3%
283	Central Cord Syndrome	3.3%
284	Alcohol-Induced Disorders, Nervous System	3.3%
285	Jet Lag Syndrome	3.3%
286	Zellweger Syndrome	3.3%
287	Presenile dementia	3.3%
288	Senile dementia	3.3%
289	Meningitis, Bacterial	3.3%
290	Meningitis, Fungal	3.3%
291	Limbic Encephalitis	3.2%
292	Myasthenia Gravis, Autoimmune, Experimental	3.2%
293	Akinetic Mutism	3.2%
294	Anoxic Encephalopathy	3.2%
295	Arachnoiditis	3.2%
296	Basal Ganglia Diseases	3.2%
297	Brain Damage, Chronic	3.2%
298	Cerebellar Diseases	3.2%
299	Encephalitis	3.2%
300	Encephalomalacia	3.2%
301	Epilepsy	3.2%
302	Hydrocephalus	3.2%
303	Congenital Hydrocephalus	3.2%
304	Hypothalamic Diseases	3.2%
305	Aseptic Meningitis	3.2%
306	Neuritis	3.2%
307	Polyneuritis	3.2%
308	Radiculitis	3.2%
309	Syringomyelia	3.2%
310	Thalamic Diseases	3.2%
311	Intracranial Hypertension	3.2%
312	Polyneuropathy	3.2%
313	Mononeuritis	3.2%
314	Aura	3.2%
315	Leukoencephalopathy	3.2%
316	Essential Tremor	3.2%
317	Neuroaxonal Dystrophies	3.2%
318	Familial Tremor	3.2%
319	Headache Disorders	3.2%
320	Mononeuropathies	3.2%
321	Intracranial Hypotension	3.2%
322	Brachial Plexus Neuropathies	3.2%
323	Radiculopathy	3.2%
324	Mononeuropathy Multiplex	3.2%
325	Nerve Root Compression	3.2%
326	Brain Edema	3.2%
327	Brain Hypoxia	3.2%
328	Aqueductal Stenosis	3.2%
329	Pneumorrhachis	3.2%
330	Writer's Cramp	3.2%
331	Chorea	3.2%
332	Amyloid Neuropathies, Familial	3.2%
333	Acrodynia	3.2%
334	Friedreich Ataxia	3.2%
335	Epilepsy, Post-Traumatic	3.2%
336	Meige Syndrome	3.2%
337	Brachial Plexus Neuritis	3.2%
338	Neuralgic Amyotrophy	3.2%
339	Cerebral Ventriculitis	3.2%
340	Polycystic Kidney, Autosomal Dominant	3.2%
341	Acrocephalosyndactylia	3.2%
342	Dwarfism	3.1%
343	Turner Syndrome	3.1%
344	Jaw Abnormalities	3.1%
345	Sjogren-Larsson Syndrome	3.1%
346	Duane Retraction Syndrome	3.1%
347	Neonatal Abstinence Syndrome	3.1%
348	Kallmann Syndrome	3.1%
349	Neuronal Ceroid-Lipofuscinoses	3%
350	Fetal Growth Retardation	3%
351	Osteogenesis Imperfecta	3%
352	Fetal Hypoxia	3%
353	Fetal Alcohol Spectrum Disorders	3%
354	Basal Cell Nevus Syndrome	3%
355	Aortic coarctation	2.9%
356	Cor Triatriatum	2.9%
357	Coronary Vessel Anomalies	2.9%
358	Dental Enamel Hypoplasia	2.9%
359	Patent ductus arteriosus	2.9%
360	Ebstein Anomaly	2.9%
361	Heart Septal Defects	2.9%
362	Hypodontia	2.9%
363	Macrostomia	2.9%
364	Microstomia	2.9%
365	Syphilis, Congenital	2.9%
366	Tetralogy of Fallot	2.9%
367	Transposition of Great Vessels	2.9%
368	Hypoplastic Left Heart Syndrome	2.9%
369	May-Thurner Syndrome	2.9%
370	Craniofacial Dysostosis	2.9%
371	Wolff-Parkinson-White Syndrome	2.9%
372	Rett Syndrome	2.9%
373	Cleft Palate	2.9%
374	Vocal Cord Paralysis	2.9%
375	Lupus Vasculitis, Central Nervous System	2.9%
376	Voice Disorders	2.8%
377	Voice Disturbance	2.8%
378	Adrenoleukodystrophy	2.8%
379	Tarsal Tunnel Syndrome	2.8%
380	Cauda Equina Syndrome	2.8%
381	Posterior Leukoencephalopathy Syndrome	2.8%
382	Posterior reversible encephalopathy syndrome	2.8%
383	Antley-Bixler Syndrome Phenotype	2.8%
384	Brain Death	2.8%
385	Coma, Post-Head Injury	2.8%
386	Poland Syndrome	2.7%
387	Amblyopia	2.7%
388	Anemia, Sickle Cell	2.7%
389	Thalassemia	2.7%
390	Paraneoplastic Cerebellar Degeneration	2.7%
391	Familial Mediterranean Fever	2.7%
392	Cerebrospinal Fluid Otorrhea	2.7%
393	Cerebrospinal Fluid Rhinorrhea	2.7%
394	Neuritis, Autoimmune, Experimental	2.7%
395	Gait Ataxia	2.7%
396	Cerebellar Neoplasms	2.7%
397	Creutzfeldt-Jakob disease	2.6%
398	Basal Ganglia Cerebrovascular Disease	2.6%
399	Dementia, Vascular	2.6%
400	Brain Hemorrhage, Traumatic	2.6%
401	Welander Distal Myopathy	2.6%
402	Brain Injuries, Diffuse	2.6%
403	Traumatic Brain Injury	2.6%
404	Cerebellar Ataxia	2.6%
405	Supratentorial Neoplasms	2.6%
406	Torticollis	2.6%
407	Multiple Sclerosis, Chronic Progressive	2.6%
408	Multiple Sclerosis, Relapsing-Remitting	2.6%
409	Autoimmune Lymphoproliferative Syndrome	2.5%
410	Klinefelter Syndrome	2.5%
411	Congenital Hyperinsulinism	2.5%
412	Brain Diseases, Metabolic	2.5%
413	Cerebrovascular Disorders	2.5%
414	Myositis	2.5%
415	Optic Atrophy	2.5%
416	Optic Neuritis	2.5%
417	Papilledema	2.5%
418	Strabismus	2.5%
419	Tolosa-Hunt Syndrome	2.5%
420	Cerebrovascular Insufficiency	2.5%
421	Isaacs syndrome	2.5%
422	Arsenic Poisoning	2.5%
423	Dementia	2.5%
424	Myotonic Disorders	2.5%
425	Central Nervous System Fungal Infections	2.5%
426	Conus Medullaris Syndrome	2.5%
427	Spinal Cord Vascular Diseases	2.5%
428	Chorioamnionitis	2.5%
429	Familial Periodic Paralysis	2.5%
430	Angioedemas, Hereditary	2.5%
431	Long QT Syndrome	2.5%
432	Platybasia	2.5%
433	Tricuspid Atresia	2.5%
434	Arrhythmogenic Right Ventricular Dysplasia	2.5%
435	Brain Diseases, Metabolic, Inborn	2.5%
436	Diabetic Neuropathies	2.4%
437	Facial Injuries	2.4%
438	Facial Neuralgia	2.4%
439	Diabetic Amyotrophy	2.4%
440	Diabetic Autonomic Neuropathy	2.4%
441	Sleep Talking	2.4%
442	Manganese Poisoning	2.4%
443	Sleep Disorders, Intrinsic	2.4%
444	Orthostatic intolerance	2.4%
445	Gonadal Dysgenesis	2.4%
446	Bronchomalacia	2.4%
447	Adrenogenital Syndrome	2.4%
448	Alcohol Withdrawal Seizures	2.4%
449	Tracheomalacia	2.4%
450	Ovotesticular Disorders of Sex Development	2.4%
451	Anosmia	2.4%
452	Ataxia	2.4%
453	Athetosis	2.4%
454	Catalepsy	2.4%
455	Dystonia	2.4%
456	Hemiplegia	2.4%
457	Locked-In Syndrome	2.4%
458	Meningeal Neoplasms	2.4%
459	Muscle Hypertonia	2.4%
460	Muscle hypotonia	2.4%
461	Myoclonus	2.4%
462	Myotonia	2.4%
463	Neuralgia	2.4%
464	Paraplegia	2.4%
465	Pseudobulbar Palsy	2.4%
466	Quadriplegia	2.4%
467	Spasm	2.4%
468	Spastic Paraplegia	2.4%
469	Status Epilepticus	2.4%
470	Taste Disorders	2.4%
471	Tremor	2.4%
472	Monoplegia	2.4%
473	Hypokinesia	2.4%
474	Paraparesis	2.4%
475	Bradykinesia	2.4%
476	Waxy flexibility	2.4%
477	Action Tremor	2.4%
478	Resting Tremor	2.4%
479	Dysosmia	2.4%
480	Quadriparesis	2.4%
481	Mercury Poisoning, Nervous System	2.4%
482	Olfaction Disorders	2.4%
483	Myokymia	2.4%
484	Lead Poisoning, Nervous System	2.4%
485	Vestibular Neuronitis	2.4%
486	Somatosensory Disorders	2.4%
487	Neuropathic pain	2.4%
488	Hyperkinesia	2.4%
489	Intention tremor	2.4%
490	Carotid Artery Injuries	2.4%
491	Menkes Kinky Hair Syndrome	2.4%
492	Hyperkeratosis, Epidermolytic	2.4%
493	Myoclonic Epilepsy	2.4%
494	Epilepsy, Temporal Lobe	2.4%
495	Epilepsy, Rolandic	2.4%
496	Benign Rolandic Epilepsy	2.4%
497	Albinism	2.4%
498	Reflex, Abnormal	2.3%
499	Hyporeflexia	2.3%
500	Hyperreflexia	2.3%
501	Optic Atrophy, Hereditary, Leber	2.3%
502	Akathisia	2.3%
503	Restlessness	2.3%
504	Psychomotor Agitation	2.3%
505	Tuberculosis, Meningeal	2.3%
506	Carpal Tunnel Syndrome	2.3%
507	Vascular Headaches	2.3%
508	neurofibroma	2.2%
509	Hypoxia-Ischemia, Brain	2.2%
510	Sciatica	2.2%
511	Tardive Dyskinesia	2.2%
512	Persistent Vegetative State	2.2%
513	Cerebral Palsy	2.1%
514	Epilepsies, Partial	2.1%
515	Epilepsy, Generalized	2.1%
516	Pseudotumor Cerebri	2.1%
517	Sciatic Neuropathy	2.1%
518	Hypertensive Encephalopathy	2.1%
519	Ulnar Neuropathies	2.1%
520	Lesion of Sciatic Nerve	2.1%
521	Simple Partial Seizures	2.1%
522	Epilepsy, Reflex	2.1%
523	Ulnar Neuritis	2.1%
524	Radial nerve compression	2.1%
525	Radial Tunnel Syndrome	2.1%
526	Peroneal Neuropathies	2.1%
527	Radial Neuropathy	2.1%
528	Median Neuropathy	2.1%
529	Sciatic Nerve Palsy	2.1%
530	Femoral Neuropathy	2.1%
531	Tibial Neuropathy	2.1%
532	Ulnar Nerve Palsy	2.1%
533	Postural Orthostatic Tachycardia Syndrome	2.1%
534	Radial nerve palsy	2.1%
535	Headache Disorders, Primary	2.1%
536	Headache Disorders, Secondary	2.1%
537	Medication overuse headache	2.1%
538	Micrognathism	2.1%
539	Pierre Robin Syndrome	2.1%
540	Alice in Wonderland Syndrome	2.1%
541	Vertebral Artery Dissection	2.1%
542	Mucopolysaccharidosis II	2.1%
543	Amnesia, Transient Global	2.1%
544	Hand-Arm Vibration Syndrome	2.1%
545	Paralysis, Obstetric	2.1%
546	Retinopathy of Prematurity	2.1%
547	Gait Apraxia	2.1%
548	Amino Acid Metabolism, Inborn Errors	2%
549	Carbohydrate Metabolism, Inborn Errors	2%
550	Metal Metabolism, Inborn Errors	2%
551	Progeria	2%
552	Wiskott-Aldrich Syndrome	2%
553	Lysosomal Storage Diseases	2%
554	Cytochrome-c Oxidase Deficiency	2%
555	Peroxisomal Disorders	2%
556	Vision Disorders	2%
557	Metamorphopsia	2%
558	Visual Impairment	2%
559	Bronchopulmonary Dysplasia	2%
560	Fibromyalgia	2%
561	Optic Neuropathy, Ischemic	2%
562	Anterior Ischemic Optic Neuropathy	2%
563	Central Nervous System Bacterial Infections	2%
564	Medial Tibial Stress Syndrome	2%
565	Brain Concussion	2%
566	Optic Nerve Glioma	2%
567	Facial Hemiatrophy	2%
568	Melkersson-Rosenthal Syndrome	2%
569	Mitochondrial Myopathies	2%
570	Juvenile Myoclonic Epilepsy	2%
571	Myoclonic Epilepsies, Progressive	2%
572	Anisocoria	2%
573	Confusion	2%
574	Facial paralysis	2%
575	Lethargy	2%
576	Memory Disorders	2%
577	Muscle Cramp	2%
578	Perceptual Disorders	2%
579	Psychomotor Disorders	2%
580	Tonic Pupil	2%
581	Eosinophilia-Myalgia Syndrome	2%
582	Anhedonia	2%
583	Disorientation	2%
584	Facial Paresis	2%
585	Memory Loss	2%
586	Hemisensory Neglect	2%
587	Dysacusis	2%
588	Toxoplasmosis, Cerebral	2%
589	Sleep Bruxism	2%
590	Muscular Atrophy	2%
591	Respiratory Paralysis	2%
592	Tetany	1.9%
593	Aortopulmonary Septal Defect	1.9%
594	Double Outlet Right Ventricle	1.9%
595	Endocardial Cushion Defects	1.9%
596	Myocardial bridging	1.9%
597	Aorticopulmonary Septal Defect	1.9%
598	Hyperandrogenism	1.9%
599	Cubital Tunnel Syndrome	1.9%
600	Diffuse Axonal Injury	1.9%
601	Brain Stem Neoplasms	1.9%
602	Retrognathia	1.9%
603	Meningitis, Cryptococcal	1.9%
604	Meningitis, Listeria	1.9%
605	Meningitis, Haemophilus	1.9%
606	Meningitis, Pneumococcal	1.9%
607	Frontotemporal dementia	1.9%
608	Kernicterus	1.9%
609	Mitochondrial Encephalomyopathies	1.9%
610	Ophthalmia Neonatorum	1.8%
611	Galactosemias	1.8%
612	Urea Cycle Disorders, Inborn	1.8%
613	Tyrosinemias	1.8%
614	Pituitary Adenoma	1.8%
615	Pituitary Neoplasms	1.8%
616	Acoustic Neuroma	1.8%
617	MELAS Syndrome	1.7%
618	Prognathism	1.7%
619	Pituitary Diseases	1.7%
620	Basal Ganglia Hemorrhage	1.7%
621	Respiratory Distress Syndrome, Newborn	1.7%
622	Fabry Disease	1.7%
623	Consciousness Disorders	1.7%
624	Mental Retardation	1.7%
625	Muscle Weakness	1.7%
626	Depressed Level of Consciousness	1.7%
627	Mental deficiency	1.7%
628	Intellectual Disability	1.7%
629	Bell Palsy	1.7%
630	Cutis Laxa	1.7%
631	Catatonia	1.7%
632	Retinitis Pigmentosa	1.7%
633	Pigmentary retinopathy	1.7%
634	Herpes Zoster Oticus	1.6%
635	Thoracic Outlet Syndrome	1.6%
636	Porokeratosis	1.6%
637	Keratoderma, Palmoplantar	1.6%
638	Aphonia	1.6%
639	Sleep Deprivation	1.6%
640	Dysphonia	1.6%
641	Chronic granulomatous disease	1.6%
642	Pituitary Apoplexy	1.6%
643	Auditory Perceptual Disorders	1.6%
644	Carotid Artery Diseases	1.6%
645	Brain Ischemia	1.6%
646	Esotropia	1.6%
647	Exotropia	1.6%
648	Hypotension, Orthostatic	1.6%
649	Sleep Apnea Syndromes	1.6%
650	Cerebrovascular accident	1.6%
651	Polymyositis	1.6%
652	Kluver-Bucy Syndrome	1.6%
653	Vasospasm, Intracranial	1.6%
654	Spinal Cord Ischemia	1.6%
655	Intracranial Arterial Diseases	1.6%
656	Post-Exercise Hypotension	1.6%
657	Giant Cell Arteritis	1.6%
658	Temporal Arteritis	1.6%
659	Hypokalemic periodic paralysis	1.6%
660	Mandibulofacial Dysostosis	1.6%
661	Disorders of Excessive Somnolence	1.6%
662	Sleep Initiation and Maintenance Disorders	1.6%
663	Night Terrors	1.6%
664	Somnambulism	1.6%
665	Trigeminal Nerve Disorder	1.6%
666	Transient Insomnia	1.6%
667	Sleep Paralysis	1.6%
668	Chronic Insomnia	1.6%
669	REM Sleep Behavior Disorder	1.6%
670	Hypersomnia	1.6%
671	Romano-Ward Syndrome	1.6%
672	Brain Contusion	1.6%
673	Sickle Cell Trait	1.6%
674	Dysgeusia	1.6%
675	Formication	1.6%
676	Hyperalgesia	1.6%
677	Hyperesthesia	1.6%
678	Hypesthesia	1.6%
679	Language Disorders	1.6%
680	Numbness	1.6%
681	Paresthesia	1.6%
682	Paraparesis, Spastic	1.6%
683	Trismus	1.6%
684	Epilepsia Partialis Continua	1.6%
685	Hypogeusia	1.6%
686	Meningeal Carcinomatosis	1.6%
687	Brown-Sequard Syndrome	1.6%
688	Lockjaw	1.6%
689	Allodynia	1.6%
690	Lead Poisoning, Nervous System, Childhood	1.6%
691	Lead Poisoning, Nervous System, Adult	1.6%
692	Brain Infarction	1.6%
693	Ageusia	1.6%
694	Tuberculosis, Central Nervous System	1.6%
695	Polyradiculopathy	1.6%
696	Post-Traumatic Headache	1.6%
697	Tension Headache	1.6%
698	Epilepsy, Complex Partial	1.6%
699	Migraine Disorders	1.6%
700	Abdominal Migraine	1.6%
701	Status Migrainosus	1.6%
702	Cervicogenic Headache	1.6%
703	Subarachnoid Hemorrhage, Traumatic	1.6%
704	Carotid Artery, Internal, Dissection	1.6%
705	Choroid Plexus Papilloma	1.6%
706	Subacute Sclerosing Panencephalitis	1.5%
707	Homocystinuria	1.4%
708	Putaminal Hemorrhage	1.4%
709	Truncus Arteriosus, Persistent	1.4%
710	Leigh Disease	1.4%
711	Goldenhar Syndrome	1.4%
712	Myalgia	1.4%
713	Porphyrias, Hepatic	1.4%
714	Infarction, Middle Cerebral Artery	1.4%
715	Infarction, Anterior Cerebral Artery	1.4%
716	Infarction, Posterior Cerebral Artery	1.4%
717	Alexia	1.4%
718	Dyslexia	1.4%
719	Peutz-Jeghers Syndrome	1.4%
720	Thrombasthenia	1.4%
721	Antithrombin III Deficiency	1.4%
722	Protein C Deficiency	1.4%
723	Afibrinogenemia	1.4%
724	Factor VII Deficiency	1.4%
725	Factor X Deficiency	1.4%
726	Factor XII Deficiency	1.4%
727	Hemophilia A	1.4%
728	Activated Protein C Resistance	1.4%
729	Factor II deficiency	1.4%
730	Factor VIII Deficiency	1.4%
731	Factor V deficiency	1.4%
732	Factor XI Deficiency	1.4%
733	Hypoprothrombinemias	1.4%
734	Glycogen storage disease type II	1.4%
735	Fanconi Anemia	1.3%
736	Nesidioblastosis	1.3%
737	Eye Injuries	1.3%
738	Anemia, Diamond-Blackfan	1.3%
739	Cluster Headache	1.3%
740	Migraine with Aura	1.3%
741	Familial Hemiplegic Migraine	1.3%
742	Chronic Paroxysmal Hemicrania	1.3%
743	SUNCT Syndrome	1.3%
744	Paroxysmal Hemicrania	1.3%
745	Cerebral Infarction	1.3%
746	Brain Stem Infarctions	1.3%
747	Orbital Myositis	1.3%
748	Diplopia	1.3%
749	Muscle Rigidity	1.3%
750	Muscle Spasticity	1.3%
751	Scotoma	1.3%
752	Photophobia	1.3%
753	Cogwheel Rigidity	1.3%
754	Hemifacial Spasm	1.3%
755	Amaurosis	1.3%
756	Blindness	1.3%
757	Nuchal Rigidity	1.3%
758	Reye Syndrome	1.3%
759	Neuroaspergillosis	1.3%
760	Pyomyositis	1.3%
761	Hematoma, Subdural	1.3%
762	Hematoma, Epidural, Cranial	1.3%
763	Intracranial Embolism and Thrombosis	1.3%
764	Hepatic Encephalopathy	1.3%
765	Agnosia	1.3%
766	Apraxias	1.3%
767	Hallucinations	1.3%
768	Hemianopsia	1.3%
769	Hyperacusis	1.3%
770	Tinnitus	1.3%
771	Visual Agnosia	1.3%
772	Anosognosia	1.3%
773	Wernicke-Korsakoff Syndrome	1.3%
774	Phonophobia	1.3%
775	Hearing Loss	1.3%
776	Sarcopenia	1.3%
777	Hydrops Fetalis	1.3%
778	Moyamoya Disease	1.3%
779	Neurofibrosarcoma	1.2%
780	Hoarseness	1.2%
781	Acute Chest Syndrome	1.2%
782	Empty Sella Syndrome	1.2%
783	Hyperpituitarism	1.2%
784	Hypopituitarism	1.2%
785	Hypophysitis	1.2%
786	Alcohol Withdrawal Delirium	1.2%
787	Arteriovenous fistula	1.2%
788	Talipes	1.2%
789	Multiple Endocrine Neoplasia	1.2%
790	Alkaptonuria	1.2%
791	Glycogen Storage Disease	1.2%
792	Hypophosphatasia	1.2%
793	Propionic acidemia	1.2%
794	Dihydropyrimidine Dehydrogenase Deficiency	1.2%
795	Cystinosis	1.2%
796	Kearns-Sayre syndrome	1.2%
797	Cerebral Arterial Diseases	1.2%
798	Vertebrobasilar Insufficiency	1.2%
799	Anterior Spinal Artery Syndrome	1.2%
800	Basilar Artery Stenosis	1.2%
801	Vertebral Artery Stenosis	1.2%
802	Sleep Apnea, Obstructive	1.2%
803	Sleep Apnea, Central	1.2%
804	Intracranial Hemorrhage, Hypertensive	1.2%
805	Transient Cerebral Ischemia	1.2%
806	Narcolepsy	1.2%
807	Trigeminal Neuralgia	1.2%
808	Kleine-Levin Syndrome	1.2%
809	Agraphia	1.2%
810	Anomia	1.2%
811	Cluttering	1.2%
812	Language Development Disorders	1.2%
813	Speech Disorders	1.2%
814	Syncope	1.2%
815	Stupor	1.2%
816	Dysgraphia	1.2%
817	Presyncope	1.2%
818	Dyslalia	1.2%
819	Lateral Medullary Syndrome	1.2%
820	Congenital Hypothyroidism	1.2%
821	Dermatitis, Atopic	1.2%
822	West Nile Fever	1.2%
823	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
824	Pseudorabies	1.1%
825	Amnesia	1.1%
826	Delirium	1.1%
827	Dissociative Amnesia	1.1%
828	Color blindness	1.1%
829	Global Amnesia	1.1%
830	Meningioma	1.1%
831	Neurosyphilis	1.1%
832	Hyperphosphaturia	1.1%
833	Hematoma, Subdural, Intracranial	1%
834	Hematoma, Subdural, Chronic	1%
835	Hematoma, Subdural, Acute	1%
836	Behcet Syndrome	1%
837	Denys-Drash Syndrome	1%
838	Hyperprolactinemia	1%
839	Congenital clubfoot	1%
840	Vertical Talus	1%
841	Subclavian Steal Syndrome	1%
842	Pick Disease of the Brain	1%
843	Cataplexy	1%
844	Aphasia	1%
845	Articulation Disorders	1%
846	Echolalia	1%
847	Stuttering	1%
848	Dysphasia	1%
849	Eye Burns	1%
850	Hyaline Membrane Disease	1%
851	Malaria, Cerebral	1%
852	Gaucher Disease	1%
853	Carotid Stenosis	1%
854	Intracranial Aneurysm	1%
855	Hypolipoproteinemias	1%
856	Papillon-Lefevre Disease	1%
857	Neurocysticercosis	1%
858	Amaurosis Fugax	1%
859	Blindness, Cortical	1%
860	Dyscalculia	1%
861	Intracranial Arteriosclerosis	1%
862	Cerebral Atherosclerosis	1%
863	Hyperlipidemia, Familial Combined	1%
864	Subarachnoid Hemorrhage	1%
865	Cerebral Arteriosclerosis	1%
866	Cerebral Hemorrhage	1%
867	Hyperlipoproteinemia Type III	1%
868	Cerebral Thrombosis	1%
869	Intracranial Embolism	1%
870	Intracranial Thrombosis	1%
871	Deafness	1%
872	Hearing Loss, Sudden	1%
873	Gerstmann Syndrome	1%
874	Hearing Loss, Bilateral	1%
875	Hearing Loss, High-Frequency	1%
876	Hearing Loss, Mixed Conductive-Sensorineural	1%
877	Prosopagnosia	1%
878	Apraxia, Ideomotor	1%
879	Charles Bonnet Syndrome	1%
880	Hearing Loss, Unilateral	1%
881	Complete Hearing Loss	1%
882	Alien Hand Syndrome	1%
883	Deaf Mutism	1%
884	Wernicke Encephalopathy	0.9%
885	AIDS Dementia Complex	0.9%
886	Phantom pain	0.9%
887	Phantom Limb Pain	0.9%
888	Lyme Neuroborreliosis	0.9%
889	Mucopolysaccharidosis III	0.9%
890	Dysarthria	0.9%
891	Dermatomyositis	0.8%
892	Corneal Scar	0.8%
893	Nephroblastoma	0.8%
894	Mutism	0.8%
895	Selective Mutism	0.8%
896	Acromegaly	0.8%
897	Lactose Intolerance	0.8%
898	Variegate Porphyria	0.8%
899	Acute intermittent porphyria	0.8%
900	Porphyria Cutanea Tarda	0.8%
901	Hyperhomocysteinemia	0.8%
902	Waterhouse-Friderichsen Syndrome	0.8%
903	Retrograde amnesia	0.8%
904	Amnesia, Anterograde	0.8%
905	Renal Aminoacidurias	0.8%
906	Fanconi Syndrome	0.8%
907	Pseudohypoaldosteronism	0.8%
908	Liddle Syndrome	0.8%
909	Carotid Artery Thrombosis	0.8%
910	Hyperlipoproteinemia Type IV	0.8%
911	Hyperlipoproteinemia Type V	0.8%
912	Cerebral Amyloid Angiopathy	0.8%
913	Glycogen Storage Disease Type I	0.8%
914	Glycogen Storage Disease Type V	0.8%
915	Sinus Thrombosis, Intracranial	0.8%
916	Tay-Sachs Disease	0.8%
917	Niemann-Pick Disease, Type C	0.8%
918	Adenomatous Polyposis Coli	0.7%
919	Alexia, Pure	0.7%
920	Cavernous Sinus Thrombosis	0.7%
921	Sagittal Sinus Thrombosis	0.7%
922	Gout	0.7%
923	Multiple Endocrine Neoplasia Type 1	0.7%
924	Pseudohypoparathyroidism	0.7%
925	Renal tubular acidosis	0.7%
926	Corneal Perforation	0.7%
927	Hypoalphalipoproteinemias	0.6%
928	Nelson Syndrome	0.6%
929	Prolactinoma	0.6%
930	Growth Hormone-Secreting Pituitary Adenoma	0.6%
931	Glycosuria, Renal	0.5%
932	Cystinuria	0.5%
933	Arthritis, Gouty	0.5%
934	Familial Hypophosphatemic Rickets	0.5%

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