MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pellagra

(UMLS:C0030783)

Definition:: A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).
UMLS ID:: C0030783
MeSH ID:: D010383

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.699.529

Synonym(s)

Pellagra

PELLAGRA

pellagra

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isoniazid		4537933	CTD
2	Niacin		View details 15242145 15953078 16519110 16713031 17712518 19061687 19155950 21128910	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Folic Acid Deficiency	49.6%
2	Thiamine Deficiency	49.6%
3	Vitamin B 12 Deficiency	49.6%
4	Vitamin B 6 Deficiency	49.6%
5	Pyridoxine Deficiency	49.6%
6	Beriberi	37.1%
7	Ascorbic Acid Deficiency	36.8%
8	Vitamin A Deficiency	36.8%
9	Vitamin D Deficiency	36.8%
10	Vitamin E Deficiency	36.8%
11	Magnesium Deficiency	29.9%
12	Potassium Deficiency	29.9%
13	Protein Deficiency	29.9%
14	Starvation	25.5%
15	Refeeding Syndrome	25.5%
16	Anemia, Pernicious	24.8%
17	Hyperhomocysteinemia	22.5%
18	Child Nutrition Disorders	21.3%
19	Hypervitaminosis A	21.3%
20	Infant Nutrition Disorders	21.3%
21	Wasting Syndrome	19.4%
22	Vitamin K Deficiency	18.9%
23	Marasmus	17.8%
24	Metabolic Diseases	14.8%
25	Wernicke Encephalopathy	14%
26	Kwashiorkor	13.9%
27	Subacute Combined Degeneration	13.2%
28	Rickets	13%
29	Scurvy	12.4%
30	Osteomalacia	9%
31	Acid-Base Imbalance	7.1%
32	Calcium Metabolism Disorders	7.1%
33	Iron Metabolism Disorders	7.1%
34	Phosphorus Metabolism Disorders	7.1%
35	Water-Electrolyte Imbalance	7.1%
36	Lipid Metabolism Disorders	7.1%
37	Mitochondrial Diseases	7.1%
38	Glucose Metabolism Disorders	7.1%
39	Renal Osteodystrophy	5.7%
40	Renal rickets	5.7%
41	Hypercalcemia	4.9%
42	Hypocalcemia	4.9%
43	Milk-Alkali Syndrome	4.9%
44	HIV Wasting Syndrome	4.9%
45	Osteopenia	4.8%
46	Brain Diseases, Metabolic	4.7%
47	Obesity	4.3%
48	Lipodystrophy	3.7%
49	Acidosis	3.6%
50	Alkalosis	3.6%
51	Amyloidosis	3.6%
52	Calcinosis	3.6%
53	Hyperglycemia	3.6%
54	Hyperinsulinism	3.6%
55	Hyperkalemia	3.6%
56	Hypernatremia	3.6%
57	Hypoglycemia	3.6%
58	Hypokalemia	3.6%
59	Hyponatremia	3.6%
60	Xanthomatosis	3.6%
61	Hypophosphatemia	3.6%
62	Metabolic acidosis	3.6%
63	Dyslipidemias	3.6%
64	Iron Overload	3.6%
65	Xanthoma	3.6%
66	Familial Hypophosphatemic Rickets	3.5%
67	Pseudohypoparathyroidism	3.1%
68	Obesity, Abdominal	3%
69	Brain Diseases, Metabolic, Inborn	2.9%
70	Diabetes Mellitus	2.6%
71	Dehydration	2.5%
72	Lipomatosis	2.5%
73	Water Intoxication	2.5%
74	Werner Syndrome	2.5%
75	Achlorhydria	2.5%
76	Amino Acid Metabolism, Inborn Errors	2.5%
77	Bloom Syndrome	2.5%
78	Carbohydrate Metabolism, Inborn Errors	2.5%
79	Metal Metabolism, Inborn Errors	2.5%
80	Osteoporosis	2.5%
81	Progeria	2.5%
82	Lysosomal Storage Diseases	2.5%
83	Bone Demineralization, Pathologic	2.5%
84	Cytochrome-c Oxidase Deficiency	2.5%
85	Peroxisomal Disorders	2.5%
86	Post-Traumatic Osteoporosis	2.5%
87	Celiac Disease	2.4%
88	Sprue, Tropical	2.4%
89	Steatorrhea	2.4%
90	Sprue	2.4%
91	Pediatric Obesity	2.4%
92	Lactose Intolerance	2.3%
93	Leigh Disease	2.2%
94	Prader-Willi Syndrome	2%
95	Hypolipoproteinemias	2%
96	Acidosis, Lactic	2%
97	Calciphylaxis	2%
98	Hemosiderosis	2%
99	Ketosis	2%
100	Ketonuria	2%
101	Ketoacidosis	2%
102	Ketonemia	2%
103	Vascular calcification	2%
104	Mitochondrial Encephalomyopathies	1.9%
105	Mitochondrial Myopathies	1.9%
106	Myelinolysis, Central Pontine	1.9%
107	Glycosuria	1.8%
108	Reye Syndrome	1.8%
109	Hepatic Encephalopathy	1.8%
110	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
111	Smith-Lemli-Opitz Syndrome	1.7%
112	Galactosemias	1.7%
113	Urea Cycle Disorders, Inborn	1.7%
114	Tyrosinemias	1.7%
115	Congenital Hyperinsulinism	1.7%
116	Diabetic Ketoacidosis	1.6%
117	Hyperlipidemia, Familial Combined	1.6%
118	Hyperphosphaturia	1.5%
119	Porphyrias, Hepatic	1.5%
120	Necrobiosis Lipoidica Diabeticorum	1.5%
121	Fanconi Anemia	1.5%
122	Hyperlipoproteinemia Type IV	1.4%
123	Hyperlipoproteinemia Type V	1.4%
124	Hyperlipoproteinemia Type III	1.4%
125	Acidosis, Respiratory	1.3%
126	Adiposis Dolorosa	1.3%
127	Alkalosis, Respiratory	1.3%
128	Renal tubular acidosis	1.3%
129	Alkaptonuria	1.3%
130	Glycogen Storage Disease	1.3%
131	Hypophosphatasia	1.3%
132	Insulin Resistance	1.3%
133	Osteoporosis, Postmenopausal	1.3%
134	Propionic acidemia	1.3%
135	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
136	Cystinosis	1.3%
137	Homocystinuria	1.3%
138	Friedreich Ataxia	1.2%
139	Hypoalphalipoproteinemias	1.2%
140	Hypercholesterolemia	1.2%
141	Hyperlipoproteinemias	1.2%
142	Hypertriglyceridemia	1.2%
143	HIV-Associated Lipodystrophy Syndrome	1.2%
144	Zellweger Syndrome	1.1%
145	Amyloid Neuropathies, Familial	1.1%
146	Menkes Kinky Hair Syndrome	1.1%
147	Neuronal Ceroid-Lipofuscinoses	1.1%
148	Kernicterus	1.1%
149	Cockayne Syndrome	1.1%
150	Glycogen storage disease type II	1.1%
151	Gestational Diabetes	1.1%
152	Latent Autoimmune Diabetes in Adults	1.1%
153	MELAS Syndrome	1%
154	Diabetes Mellitus, Experimental	1%
155	Hepatolenticular Degeneration	1%
156	Nephrocalcinosis	1%
157	Tetany	1%
158	Refsum Disease	1%
159	Glycosuria, Renal	1%
160	Cerebral Amyloid Angiopathy	1%
161	Adrenoleukodystrophy	1%
162	Nesidioblastosis	1%
163	Ataxia Telangiectasia	0.9%
164	Optic Atrophy, Hereditary, Leber	0.9%
165	Kearns-Sayre syndrome	0.9%
166	Gaucher Disease	0.9%
167	Xeroderma Pigmentosum	0.8%
168	Familial Periodic Paralysis	0.8%
169	Primary amyloidosis	0.8%
170	Variegate Porphyria	0.8%
171	Acute intermittent porphyria	0.8%
172	Porphyria Cutanea Tarda	0.8%
173	Renal Aminoacidurias	0.8%
174	Fanconi Syndrome	0.8%
175	Pseudohypoaldosteronism	0.8%
176	Liddle Syndrome	0.8%
177	Mucopolysaccharidosis III	0.8%
178	Glycogen Storage Disease Type I	0.8%
179	Glycogen Storage Disease Type V	0.8%
180	Gout	0.7%
181	Amyotrophic Lateral Sclerosis	0.7%
182	Antley-Bixler Syndrome Phenotype	0.7%
183	Fabry Disease	0.7%
184	Sjogren-Larsson Syndrome	0.6%
185	CREST Syndrome	0.6%
186	Niemann-Pick Disease, Type C	0.6%
187	Canavan Disease	0.5%
188	Alexander Disease	0.5%
189	Mucopolysaccharidosis II	0.5%
190	Albinism	0.5%
191	Tay-Sachs Disease	0.5%
192	Hypokalemic periodic paralysis	0.5%
193	Frontotemporal dementia	0.5%
194	Cystinuria	0.5%
195	Ichthyosis, X-Linked	0.4%
196	Arthritis, Gouty	0.4%

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