MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Eye Abnormalities

(UMLS:C0015393)

Definition:: Congenital absence of or defects in structures of the eye; may also be hereditary.
UMLS ID:: C0015393
MeSH ID:: D005124

Classification 1:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.250

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.384

Synonym(s)

Eye Abnormalities

Congenital Eye Disorder

Congenital Ophthalmologic Abnormality

Congenital abnormality of eye

Congenital anomaly of eye

Congenital anomaly of eye, NOS

Congenital anomaly of the globe

Congenital anomaly;eye

Congenital deformity of eye

10.

Congenital deformity of eye, NOS

11.

Congenital disease or syndrome of eye

12.

Congenital eye anomalies

13.

Congenital eye disease

14.

Congenital eye disorder

15.

Congenital eye syndrome

16.

Congenital malformation of eye

17.

Congenital malformation of eye, unspecified

18.

Congenital ocular syndrome

19.

Congenital syndrome of the eye

20.

EYE ABNORMALITY

21.

EYE ANOMALY

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	19218331	CTD
2	Alcohols	24646710 25883026	CTD
3	Aspirin	12072809	CTD
4	Benomyl	1914497	CTD
5	Cocaine	1565445	CTD
6	Dextroamphetamine	3563934	CTD
7	Dipyridamole	25883026	CTD
8	Methanol	23207165	CTD
9	Polychlorinated Dibenzodioxins	11564622 30398377	CTD
10	Thalidomide	21505091 28892372	CTD
11	Tretinoin	9664655 16938888 22262565	CTD
12	Trimethadione	50427	CTD
13	Valproic Acid	3142446 11986102	CTD
14	azadirachtin	17517339	CTD
15	benz(a)anthracene	29630969	CTD
16	bisphenol A	19218331	CTD
17	di-n-hexyl phthalate	19391110	CTD
18	glyphosate	20695457	CTD
19	kenpaullone	25711857	CTD
20	methoxyacetic acid	22898132	CTD
21	methylparaben	23637088	CTD
22	pyrazolanthrone	21751222	CTD
23	retene	29630969	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Abnormalities, Drug-Induced	30%
2	Situs Inversus	30%
3	Beckwith-Wiedemann Syndrome	29.6%
4	Wolf-Hirschhorn Syndrome	29.6%
5	Aicardi's syndrome	27.5%
6	Holoprosencephaly	27.3%
7	CHARGE Syndrome	25.7%
8	Smith-Magenis syndrome	24.7%
9	Cri-du-Chat Syndrome	24.3%
10	Down Syndrome	24.3%
11	Trisomy 21	24.3%
12	Anencephaly	23.1%
13	Cardiovascular Abnormalities	23.1%
14	Retinal Degeneration	22.2%
15	Skin Abnormalities	22.2%
16	Lymphatic Abnormalities	22.2%
17	Congenital Microtia	22.2%
18	Prune Belly Syndrome	22%
19	Twins, Conjoined	22%
20	Waardenburg Syndrome	22%
21	Congenital diaphragmatic hernia	21.6%
22	Rubinstein-Taybi Syndrome	21.5%
23	Asthenopia	21.1%
24	Conjunctival Diseases	21.1%
25	Corneal Diseases	21.1%
26	Eyelid Diseases	21.1%
27	Lacrimal Apparatus Diseases	21.1%
28	Lens Diseases	21.1%
29	Ocular Hypertension	21.1%
30	Ocular Hypotension	21.1%
31	Retinal Diseases	21.1%
32	Scleral Diseases	21.1%
33	Vitreous Detachment	21.1%
34	Posterior Vitreous Detachment	21.1%
35	Ectodermal Dysplasia	20.8%
36	Aplasia Cutis Congenita	20.8%
37	Prader-Willi Syndrome	20.6%
38	Xerophthalmia	20%
39	Low Tension Glaucoma	20%
40	Iridocorneal endothelial syndrome	20%
41	Keratoconjunctivitis Sicca	19.4%
42	Maxillofacial Abnormalities	19.3%
43	Dural Arteriovenous Fistula	19.3%
44	Retinitis Pigmentosa	19.1%
45	Pigmentary retinopathy	19.1%
46	Dextrocardia	19.1%
47	Chorioretinitis	18.8%
48	Urogenital Abnormalities	18.2%
49	Pars Planitis	18%
50	Duane Retraction Syndrome	17.9%
51	Keratoconjunctivitis	17.9%
52	Kartagener Syndrome	17.8%
53	Uveal Neoplasms	17.4%
54	Eyelid Neoplasms	17.3%
55	Retinal Hemorrhage	17.3%
56	Alstrom Syndrome	17%
57	Anus, Imperforate	16.4%
58	Hydranencephaly	16.4%
59	Neural Tube Defects	16.4%
60	Retinopathy of Prematurity	16.4%
61	Tethered Cord Syndrome	16.4%
62	Iniencephaly	16.4%
63	Craniorachischisis	16.4%
64	Limb Deformities, Congenital	16.4%
65	Exencephaly	16.4%
66	Septo-Optic Dysplasia	16.4%
67	Craniofacial Abnormalities	16.4%
68	Cortical Dysplasia	16.4%
69	Malformations of Cortical Development	16.4%
70	Anorectal Malformations	16.4%
71	Choroiditis	16.3%
72	Iridocyclitis	16.3%
73	Iritis	16.3%
74	Microcephaly	16.2%
75	Macrocephaly	16.2%
76	Bloom Syndrome	16.1%
77	Marfan Syndrome	15.8%
78	Genetic Diseases, Inborn	15.8%
79	Corneal Ulcer	15.7%
80	Choroid Hemorrhage	15.6%
81	Nail-Patella Syndrome	15.5%
82	Eye Infection	15.4%
83	Eye Manifestations	15.4%
84	Eye Neoplasms	15.4%
85	Optic Neuropathy	15.4%
86	Retinal Dysplasia	15.3%
87	Xeroderma	15.3%
88	Mobius Syndrome	15.3%
89	Porencephaly	15.3%
90	Angioid Streaks	15%
91	Anisometropia	15%
92	Aphakia	15%
93	Astigmatism	15%
94	Blepharitis	15%
95	Blepharoptosis	15%
96	Blepharospasm	15%
97	Choroid Diseases	15%
98	Conjunctivitis	15%
99	Corneal edema	15%
100	Corneal Opacity	15%
101	Dacryocystitis	15%
102	Dry Eye Syndromes	15%
103	Ectropion	15%
104	Enophthalmos	15%
105	Entropion	15%
106	Episcleritis	15%
107	Exophthalmos	15%
108	Glaucoma	15%
109	Iris Diseases	15%
110	Keratitis	15%
111	Keratoconus	15%
112	Lacrimal Duct Obstruction	15%
113	Lens dislocation	15%
114	Lens Subluxation	15%
115	Mydriasis	15%
116	Myopia	15%
117	Presbyopia	15%
118	Pterygium	15%
119	Retinal Detachment	15%
120	Retinitis	15%
121	Scleritis	15%
122	Uveitis	15%
123	Corneal Neovascularization	15%
124	Orbital Pseudotumor	15%
125	Cataract	15%
126	Pinguecula	15%
127	Trichiasis	15%
128	Classical Lissencephalies and Subcortical Band Heterotopias	15%
129	Acrocephalosyndactylia	14.8%
130	Craniosynostosis	14.6%
131	Syndactyly	14.6%
132	Brachycephaly	14.6%
133	Scimitar Syndrome	14.5%
134	Fragile X Syndrome	14.5%
135	Aniridia	14.1%
136	Corneal Scar	14%
137	Polycystic Kidney Diseases	13.8%
138	Williams Syndrome	13.8%
139	Mandibulofacial Dysostosis	13.4%
140	Amelia	13.3%
141	Arachnodactyly	13.3%
142	Ectopia Cordis	13.3%
143	Ectromelia	13.3%
144	Hemimelia	13.3%
145	Meningomyelocele	13.3%
146	Phocomelia	13.3%
147	Sirenomelia	13.3%
148	Spina Bifida	13.3%
149	Polydactyly	13.3%
150	Brachydactyly	13.3%
151	Plagiocephaly	13.3%
152	Lower Extremity Deformities, Congenital	13.3%
153	Upper Extremity Deformities, Congenital	13.3%
154	Single umbilical artery	13.3%
155	Turner Syndrome	13.2%
156	Laryngostenosis	13%
157	Mouth Abnormalities	13%
158	Primary Ciliary Dyskinesia	13%
159	Poland Syndrome	12.9%
160	Noonan Syndrome	12.9%
161	Cockayne Syndrome	12.9%
162	Hordeolum	12.9%
163	Esophageal Atresia	12.9%
164	Intestinal Atresia	12.9%
165	Horseshoe Kidney	12.9%
166	Pectus excavatum	12.9%
167	Klippel-Feil Syndrome	12.8%
168	Gastroschisis	12.8%
169	Synostosis	12.8%
170	Congenital nystagmus	12.8%
171	Color blindness	12.8%
172	Trachoma	12.7%
173	Acrodermatitis	12.7%
174	Lymphangiectasis, Intestinal	12.7%
175	Gianotti-Crosti Syndrome	12.7%
176	Cleft Palate	12.5%
177	Jaw Abnormalities	12.3%
178	Angle Closure Glaucoma	12.2%
179	Glaucoma, Open-Angle	12.2%
180	Macular degeneration	12.2%
181	Panuveitis	12.2%
182	Retinal Drusen	12.2%
183	Retinal Necrosis Syndrome, Acute	12.2%
184	Retinoschisis	12.2%
185	Exfoliation Syndrome	12.2%
186	Ocular Motility Disorders	12.1%
187	Cyclophoria	12.1%
188	Retinoblastoma	12.1%
189	Pupil Disorders	11.9%
190	Epidermolysis Bullosa	11.9%
191	Abnormalities, Radiation-Induced	11.9%
192	Smith-Lemli-Opitz Syndrome	11.8%
193	Dermal Sinus	11.8%
194	Spina Bifida Cystica	11.8%
195	Spina Bifida Occulta	11.8%
196	Lissencephaly	11.8%
197	Polymicrogyria	11.8%
198	Pachygyria	11.8%
199	Schizencephaly	11.8%
200	Periventricular Nodular Heterotopia	11.8%
201	Acanthamoeba Keratitis	11.8%
202	Eye Hemorrhage	11.8%
203	Keratitis, Herpetic	11.7%
204	Cytomegalovirus Retinitis	11.7%
205	Vision Disorders	11.7%
206	Metamorphopsia	11.7%
207	Visual Impairment	11.7%
208	Klinefelter Syndrome	11.7%
209	Ichthyosis, X-Linked	11.6%
210	Eye Injuries	11.6%
211	Bacterial conjunctivitis	11.6%
212	Fetal Diseases	11.5%
213	Corneal Perforation	11.4%
214	Polycystic Kidney, Autosomal Dominant	11.3%
215	Micrognathism	11%
216	Pierre Robin Syndrome	11%
217	Albinism	11%
218	Ophthalmia Neonatorum	11%
219	Endophthalmitis	10.9%
220	Optic Atrophy	10.9%
221	Optic Neuritis	10.9%
222	Papilledema	10.9%
223	Pemphigoid, Benign Mucous Membrane	10.9%
224	Retinal Artery Occlusion	10.9%
225	Strabismus	10.9%
226	Tolosa-Hunt Syndrome	10.9%
227	Orbital Cellulitis	10.9%
228	Retinal Vasculitis	10.9%
229	Hypertensive Retinopathy	10.9%
230	Retrobulbar Hemorrhage	10.9%
231	Corneal Endothelial Cell Loss	10.9%
232	Arthrogryposis	10.8%
233	Choanal Atresia	10.8%
234	Tracheobronchomegaly	10.8%
235	Anterior uveitis	10.8%
236	Uveitis, Posterior	10.8%
237	Laryngocele	10.8%
238	Optic Atrophy, Hereditary, Leber	10.8%
239	Hyphema	10.8%
240	Retinal Neovascularization	10.8%
241	Vitreous Hemorrhage	10.8%
242	Choledochal Cyst	10.7%
243	Hermaphroditism	10.7%
244	Disorders of Sex Development	10.7%
245	Cryptorchidism	10.6%
246	Hypospadias	10.6%
247	Central Nervous System Cysts	10.5%
248	Aortic coarctation	10.5%
249	Cor Triatriatum	10.5%
250	Coronary Vessel Anomalies	10.5%
251	Dental Enamel Hypoplasia	10.5%
252	Patent ductus arteriosus	10.5%
253	Ebstein Anomaly	10.5%
254	Heart Septal Defects	10.5%
255	Hypodontia	10.5%
256	Macrostomia	10.5%
257	Meningocele	10.5%
258	Microstomia	10.5%
259	Tetralogy of Fallot	10.5%
260	Transposition of Great Vessels	10.5%
261	Hypoplastic Left Heart Syndrome	10.5%
262	May-Thurner Syndrome	10.5%
263	Encephalocele	10.5%
264	Dandy-Walker Syndrome	10.5%
265	Craniofacial Dysostosis	10.4%
266	Wolff-Parkinson-White Syndrome	10.3%
267	POEMS Syndrome	10.3%
268	Abdominal Cramps	10%
269	Amniotic Band Syndrome	10%
270	Asphyxia Neonatorum	10%
271	Infant, Premature, Diseases	10%
272	Panophthalmitis	10%
273	Infantile Colic	10%
274	Hyperkeratosis, Epidermolytic	9.8%
275	Retrognathia	9.8%
276	Cystic Fibrosis	9.8%
277	Charcot-Marie-Tooth Disease	9.7%
278	Antley-Bixler Syndrome Phenotype	9.7%
279	Sjogren-Larsson Syndrome	9.6%
280	Aortopulmonary Septal Defect	9.3%
281	Double Outlet Right Ventricle	9.3%
282	Endocardial Cushion Defects	9.3%
283	Myocardial bridging	9.3%
284	Aorticopulmonary Septal Defect	9.3%
285	Pseudoxanthoma Elasticum	9.2%
286	Laryngomalacia	9.2%
287	Kallmann Syndrome	9.1%
288	Pectus carinatum	9.1%
289	Bladder Exstrophy	9%
290	Epispadias	9%
291	Hyperandrogenism	8.9%
292	Multicystic Dysplastic Kidney	8.9%
293	Esotropia	8.8%
294	Exotropia	8.8%
295	Choroidal Neovascularization	8.8%
296	Prognathism	8.8%
297	Blepharophimosis	8.7%
298	Optic Neuropathy, Ischemic	8.7%
299	Anterior Ischemic Optic Neuropathy	8.7%
300	Truncus Arteriosus, Persistent	8.7%
301	Goldenhar Syndrome	8.7%
302	Long QT Syndrome	8.7%
303	Platybasia	8.7%
304	Tricuspid Atresia	8.7%
305	Arrhythmogenic Right Ventricular Dysplasia	8.7%
306	Gonadal Dysgenesis	8.6%
307	Bronchomalacia	8.6%
308	Adrenogenital Syndrome	8.6%
309	Tracheomalacia	8.6%
310	Ovotesticular Disorders of Sex Development	8.6%
311	Retinal Vein Occlusion	8.6%
312	Anisocoria	8.5%
313	Diabetic Retinopathy	8.5%
314	Tonic Pupil	8.5%
315	Eye pain	8.5%
316	Orbital Myositis	8.5%
317	Diplopia	8.4%
318	Scotoma	8.4%
319	Photophobia	8.4%
320	Amaurosis	8.4%
321	Blindness	8.4%
322	Xeroderma Pigmentosum	8.3%
323	Meconium Aspiration Syndrome	8.2%
324	Tuberous Sclerosis	8.1%
325	Zellweger Syndrome	7.8%
326	Neoplastic Syndromes, Hereditary	7.7%
327	Romano-Ward Syndrome	7.6%
328	Refsum Disease	7.6%
329	Basal Cell Nevus Syndrome	7.4%
330	Familial Mediterranean Fever	7.3%
331	Talipes	7.3%
332	Anemia, Neonatal	7.3%
333	Multiple Epiphyseal Dysplasia	7.3%
334	Osteochondrodysplasias	7.3%
335	Pelger-Huet Anomaly	7.3%
336	Persistent Fetal Circulation Syndrome	7.3%
337	Werner Syndrome	7.3%
338	Myasthenic Syndromes, Congenital	7.3%
339	Umbilical hernia	7.2%
340	Uveomeningoencephalitic Syndrome	7.1%
341	Herpes Zoster Ophthalmicus	7.1%
342	Ophthalmoplegia	7%
343	External Ophthalmoplegia	7%
344	Congenital clubfoot	7%
345	Vertical Talus	7%
346	Amblyopia	7%
347	Hemianopsia	6.9%
348	Anemia, Sickle Cell	6.9%
349	Thalassemia	6.9%
350	Amaurosis Fugax	6.9%
351	Blindness, Cortical	6.9%
352	Muscular Dystrophy, Duchenne	6.9%
353	Rett Syndrome	6.9%
354	Mucopolysaccharidosis II	6.3%
355	Behcet Syndrome	6.2%
356	Dwarfism	6%
357	Graves Disease	5.9%
358	Neonatal Abstinence Syndrome	5.9%
359	Horner Syndrome	5.8%
360	Fetal Growth Retardation	5.7%
361	Arteriovenous fistula	5.7%
362	Muscular Dystrophy	5.7%
363	Osteogenesis Imperfecta	5.7%
364	Fetal Hypoxia	5.7%
365	Fetal Alcohol Spectrum Disorders	5.7%
366	Sickle Cell Trait	5.7%
367	Toxoplasmosis, Congenital	5.6%
368	Syphilis, Congenital	5.6%
369	Menkes Kinky Hair Syndrome	5.5%
370	Paralysis, Obstetric	5.5%
371	Amino Acid Metabolism, Inborn Errors	5.4%
372	Carbohydrate Metabolism, Inborn Errors	5.4%
373	Metal Metabolism, Inborn Errors	5.4%
374	Progeria	5.4%
375	Lysosomal Storage Diseases	5.4%
376	Cytochrome-c Oxidase Deficiency	5.4%
377	Peroxisomal Disorders	5.4%
378	Bronchopulmonary Dysplasia	5.3%
379	Wiskott-Aldrich Syndrome	5.1%
380	Neuronal Ceroid-Lipofuscinoses	5.1%
381	Kearns-Sayre syndrome	4.8%
382	Autoimmune Lymphoproliferative Syndrome	4.8%
383	Congenital Hyperinsulinism	4.7%
384	Chorioamnionitis	4.7%
385	Angioedemas, Hereditary	4.6%
386	Opsoclonus-Myoclonus Syndrome	4.6%
387	Myotonic Dystrophy	4.5%
388	Adrenoleukodystrophy	4.5%
389	Glycogen storage disease type II	4.4%
390	Alkaptonuria	4.4%
391	Glycogen Storage Disease	4.4%
392	Hypophosphatasia	4.4%
393	Propionic acidemia	4.4%
394	Dihydropyrimidine Dehydrogenase Deficiency	4.4%
395	Cystinosis	4.4%
396	Fabry Disease	4.4%
397	Respiratory Distress Syndrome, Newborn	4.3%
398	Denys-Drash Syndrome	4.3%
399	Mucopolysaccharidosis III	4.3%
400	Acute Chest Syndrome	4.3%
401	Cutis Laxa	4.3%
402	Sicca Syndrome	4.3%
403	Sjogren's Syndrome	4.3%
404	Porokeratosis	4.2%
405	Keratoderma, Palmoplantar	4.2%
406	Chronic granulomatous disease	4.2%
407	Galactosemias	4.2%
408	Urea Cycle Disorders, Inborn	4.2%
409	Tyrosinemias	4.2%
410	Welander Distal Myopathy	4.2%
411	Hepatolenticular Degeneration	4.1%
412	Amyloid Neuropathies, Familial	4.1%
413	Miller Fisher Syndrome	4%
414	Hydrops Fetalis	4%
415	Glycogen Storage Disease Type I	3.9%
416	Glycogen Storage Disease Type V	3.9%
417	Ophthalmoplegic Migraine	3.8%
418	Gaucher Disease	3.8%
419	Progressive supranuclear palsy	3.8%
420	Hyperphosphaturia	3.7%
421	Tay-Sachs Disease	3.6%
422	Homocystinuria	3.6%
423	Porphyrias, Hepatic	3.5%
424	Leigh Disease	3.5%
425	Canavan Disease	3.5%
426	Alexander Disease	3.5%
427	Hyaline Membrane Disease	3.5%
428	Peutz-Jeghers Syndrome	3.5%
429	Myotonia Congenita	3.5%
430	Thrombasthenia	3.5%
431	Antithrombin III Deficiency	3.5%
432	Protein C Deficiency	3.5%
433	Brain Diseases, Metabolic, Inborn	3.5%
434	Afibrinogenemia	3.4%
435	Dystonia Musculorum Deformans	3.4%
436	Factor VII Deficiency	3.4%
437	Factor X Deficiency	3.4%
438	Factor XII Deficiency	3.4%
439	Hemophilia A	3.4%
440	Hypolipoproteinemias	3.4%
441	Leukomalacia, Periventricular	3.4%
442	Papillon-Lefevre Disease	3.4%
443	Activated Protein C Resistance	3.4%
444	Factor II deficiency	3.4%
445	Factor VIII Deficiency	3.4%
446	Factor V deficiency	3.4%
447	Factor XI Deficiency	3.4%
448	Hypoprothrombinemias	3.4%
449	Hyperlipidemia, Familial Combined	3.4%
450	Hyperlipoproteinemia Type III	3.4%
451	Fanconi Anemia	3.4%
452	Nesidioblastosis	3.4%
453	Lafora Disease	3.4%
454	Unverricht-Lundborg Syndrome	3.4%
455	Anemia, Diamond-Blackfan	3.4%
456	Neuromyelitis Optica	3.4%
457	Niemann-Pick Disease, Type C	3.3%
458	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
459	Ataxia Telangiectasia	3.1%
460	Hypoalphalipoproteinemias	3.1%
461	Multiple Endocrine Neoplasia	3.1%
462	Congenital Hypothyroidism	3%
463	Dermatitis, Atopic	3%
464	Familial Periodic Paralysis	2.9%
465	Lactose Intolerance	2.9%
466	Variegate Porphyria	2.9%
467	Acute intermittent porphyria	2.9%
468	Porphyria Cutanea Tarda	2.9%
469	Hyperhomocysteinemia	2.8%
470	Renal Aminoacidurias	2.8%
471	Fanconi Syndrome	2.8%
472	Pseudohypoaldosteronism	2.8%
473	Liddle Syndrome	2.8%
474	Hyperlipoproteinemia Type IV	2.8%
475	Hyperlipoproteinemia Type V	2.8%
476	Optic Nerve Glioma	2.7%
477	Kernicterus	2.6%
478	Hypokalemic periodic paralysis	2.6%
479	Cystinuria	2.5%
480	Gout	2.5%
481	Multiple Endocrine Neoplasia Type 1	2.5%
482	Pseudohypoparathyroidism	2.5%
483	Friedreich Ataxia	2.4%
484	Renal tubular acidosis	2.4%
485	Huntington Disease	2.3%
486	Arthritis, Gouty	2.2%
487	Familial Hypophosphatemic Rickets	2.1%
488	Nephroblastoma	2%
489	Glycosuria, Renal	1.9%
490	Adenomatous Polyposis Coli	1.8%
491	MELAS Syndrome	1.5%

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