MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Purpura, Hyperglobulinemic

(UMLS:C0034151)

Definition:: Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.
UMLS ID:: C0034151
MeSH ID:: D011694

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.454.550

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.802.250|C15.378.463.515.550

Classification 3:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.414.950.250|C23.888.885.687.250

Synonym(s)

Purpura, Hyperglobulinemic

Hyperglobulinemic purpura

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Phenylbutazone		5755571	CTD
2	Tartrazine		10068932	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Purpura Fulminans	40.5%
2	Thrombocytopenic purpura	36%
3	Purpura, Thrombotic Thrombocytopenic	32.4%
4	Disseminated Intravascular Coagulation	32%
5	Ecchymosis	32%
6	Shwartzman Phenomenon	31%
7	Autoimmune thrombocytopenia	30.7%
8	Immune thrombocytopenic purpura	30.7%
9	Waterhouse-Friderichsen Syndrome	30%
10	Thrombocythemia, Essential	29.3%
11	Cryoglobulinemia	27.5%
12	Protein S Deficiency	27%
13	Hemangioma, Cavernous	26%
14	Scurvy	25.9%
15	Afibrinogenemia	25.4%
16	Factor VII Deficiency	25.4%
17	Factor X Deficiency	25.4%
18	Factor XII Deficiency	25.4%
19	Hemophilia A	25.4%
20	Factor II deficiency	25.4%
21	Factor VIII Deficiency	25.4%
22	Factor V deficiency	25.4%
23	Factor XI Deficiency	25.4%
24	Hypoprothrombinemias	25.4%
25	Thrombasthenia	24.7%
26	Vitamin K Deficiency	24.4%
27	Waldenstrom Macroglobulinemia	24.4%
28	Multiple Myeloma	22.6%
29	Activated Protein C Resistance	21%
30	Antithrombin III Deficiency	20.4%
31	Protein C Deficiency	20.4%
32	Polydipsia	19%
33	Leukocytosis	17.9%
34	Pleocytosis	17.9%
35	Pseudoxanthoma Elasticum	17.6%
36	Wiskott-Aldrich Syndrome	17.5%
37	Postoperative Hemorrhage	16.8%
38	Shock, Hemorrhagic	16.8%
39	jaundice	16.8%
40	Anemia	16.5%
41	Blood Platelet Disorders	16.5%
42	Bone Marrow Diseases	16.5%
43	Leukocyte Disorders	16.5%
44	Methemoglobinemia	16.5%
45	Pancytopenia	16.5%
46	Polycythemia	16.5%
47	Sulfhemoglobinemia	16.5%
48	Thrombophilia	16.5%
49	Erythrocytosis	16.5%
50	Hypergammaglobulinemia	15.8%
51	Eye Hemorrhage	15.1%
52	Hemoptysis	14.9%
53	Livedo Reticularis	14.8%
54	Bone Marrow Neoplasms	14.8%
55	Transfusion Reaction	14.6%
56	Hypotensive Transfusion Reaction	14.6%
57	Pregnancy Complications, Hematologic	14.3%
58	Hematologic Neoplasms	14.3%
59	Reperfusion Injury	14.2%
60	Vasoplegia	14.2%
61	Thrombocytosis	14%
62	Intermittent Claudication	13.6%
63	Epistaxis	13.3%
64	Myocardial Reperfusion Injury	13.1%
65	Flushing	13%
66	Hematoma	13%
67	Pallor	13%
68	Exsanguination	13%
69	Polycythemia Vera	12.9%
70	Vascular Remodeling	12.6%
71	Cardiac Output, High	12.4%
72	Myocardial Stunning	12.4%
73	Low Cardiac Output Syndrome	12.4%
74	Granuloma	12.3%
75	Hematoma, Subdural	11.6%
76	Hematoma, Epidural, Cranial	11.6%
77	Myocardial Ischemia	11.4%
78	Postoperative Nausea and Vomiting	11.4%
79	Menorrhagia	11.4%
80	Gastrointestinal Hemorrhage	11.3%
81	Hemarthrosis	11.3%
82	Hemoperitoneum	11.3%
83	Hemothorax	11.3%
84	Pruritus	11.3%
85	Splenic Infarction	11.3%
86	Erythema	11.3%
87	Necrolytic Migratory Erythema	11.3%
88	Retrobulbar Hemorrhage	11.3%
89	Aortic Aneurysm	11.2%
90	Aortitis	11.2%
91	Infarction	11.2%
92	Leriche Syndrome	11.2%
93	Periphlebitis	11.2%
94	Phlebitis	11.2%
95	Thromboangiitis Obliterans	11.2%
96	Systemic Inflammatory Response Syndrome	11.2%
97	Uterine hemorrhage	11.2%
98	Hemoglobinuria, Paroxysmal	11.1%
99	Jaundice, Obstructive	11.1%
100	Leukemoid Reaction	11.1%
101	Ascites	11%
102	Asthenia	11%
103	Body Temperature Changes	11%
104	Cyanosis	11%
105	Edema	11%
106	Failure to Thrive	11%
107	Fatigue	11%
108	Feminization	11%
109	Fetal Distress	11%
110	Fibrosis	11%
111	Gliosis	11%
112	Growth Disorders	11%
113	Hyperbilirubinemia	11%
114	Hyperplasia	11%
115	Hypomenorrhea	11%
116	Inflammation	11%
117	Intraoperative Complications	11%
118	Ischemia	11%
119	Lithiasis	11%
120	Malacoplakia	11%
121	Menstruation Disturbances	11%
122	Metaplasia	11%
123	Motion Sickness	11%
124	Nerve Degeneration	11%
125	Ochronosis	11%
126	Polymenorrhea	11%
127	Postoperative Complications	11%
128	Sclerosis	11%
129	Shock	11%
130	Signs and Symptoms, Digestive	11%
131	Signs and Symptoms, Respiratory	11%
132	Ulcer	11%
133	Chills	11%
134	Lassitude	11%
135	Hyperammonemia	11%
136	Hyperamylasemia	11%
137	Teratogenesis	11%
138	Cardiac Death	11%
139	Hypovolemia	11%
140	Pseudophakia	11%
141	Hyperuricemia	11%
142	Urological Manifestations	11%
143	Leukoaraiosis	11%
144	Dysbacteriosis	11%
145	Mobility Limitation	11%
146	Delayed Graft Function	11%
147	Cirrhosis	11%
148	Somnolence	11%
149	Neointima	11%
150	Dysbiosis	11%
151	Anemia, Diamond-Blackfan	10.8%
152	Hydrops Fetalis	10.7%
153	Retinal Vein Occlusion	10.6%
154	Muscle Weakness	10.3%
155	Thrombophlebitis	10.3%
156	Renal Colic	10.2%
157	Lymphatic Diseases	10.1%
158	Pathological Conditions, Anatomical	10.1%
159	Subarachnoid Hemorrhage	10.1%
160	Cerebral Hemorrhage	10.1%
161	Arteriovenous fistula	10%
162	Agammaglobulinemia	9.9%
163	Aneurysm	9.9%
164	Angiomatosis	9.9%
165	Aortic Diseases	9.9%
166	Arterial Occlusive Diseases	9.9%
167	Hyperemia	9.9%
168	Hypotension	9.9%
169	Superior Vena Cava Syndrome	9.9%
170	Telangiectasis	9.9%
171	Vasculitis	9.9%
172	Venous Insufficiency	9.9%
173	Peripheral Vascular Diseases	9.9%
174	Embolism and Thrombosis	9.9%
175	Angiodysplasia	9.9%
176	Capillary Leak Syndrome	9.9%
177	Prehypertension	9.9%
178	Malignant Atrophic Papulosis	9.8%
179	Aortic Rupture	9.8%
180	Anemia, Sickle Cell	9.8%
181	Thalassemia	9.8%
182	Hematuria	9.8%
183	Anemia, Hemolytic	9.8%
184	Anemia, Macrocytic	9.8%
185	Eosinophilia	9.8%
186	Hypoproteinemia	9.8%
187	Leukopenia	9.8%
188	Thrombocytopenia	9.8%
189	Leukostasis	9.8%
190	MYELODYSPLASTIC SYNDROME	9.8%
191	Postphlebitic Syndrome	9.8%
192	No-Reflow Phenomenon	9.8%
193	Coronary Aneurysm	9.8%
194	Hematemesis	9.8%
195	Shock, Cardiogenic	9.8%
196	Extravasation of Diagnostic and Therapeutic Materials	9.7%
197	Eye Manifestations	9.7%
198	Neoplastic Processes	9.7%
199	Neurologic Manifestations	9.7%
200	Necrosis	9.5%
201	Reticulocytosis	9.5%
202	Granulomatosis, Orofacial	9.5%
203	Pigmentation Disorders	9.5%
204	Respiratory Aspiration	9.5%
205	Acantholysis	9.4%
206	Chromosome Aberrations	9.4%
207	Dehydration	9.4%
208	Abdominal Pain	9.3%
209	Pain, Postoperative	9.3%
210	Primary Graft Dysfunction	9.3%
211	Moyamoya Disease	9.2%
212	Eosinophilic Granuloma	9.2%
213	Carotid Artery Thrombosis	9.1%
214	Mucocutaneous Lymph Node Syndrome	9.1%
215	Kernicterus	9%
216	Angina Pectoris	9%
217	Hematoma, Subdural, Intracranial	8.9%
218	Hematoma, Subdural, Chronic	8.9%
219	Hematoma, Subdural, Acute	8.9%
220	Chromosomal Instability	8.8%
221	Vascular System Injuries	8.7%
222	Infectious Mononucleosis	8.7%
223	Monoclonal Gammopathy of Undetermined Significance	8.7%
224	Blue Toe Syndrome	8.7%
225	Hematoma, Epidural, Spinal	8.6%
226	Compartment syndromes	8.6%
227	Hepatic Veno-Occlusive Disease	8.6%
228	Peliosis Hepatis	8.6%
229	Varicocele	8.6%
230	Intracranial Embolism and Thrombosis	8.5%
231	Carotid Stenosis	8.5%
232	Intracranial Aneurysm	8.5%
233	Coronary Thrombosis	8.5%
234	Coronary Artery Disease	8.5%
235	Anemia, Neonatal	8.5%
236	Cerebrovascular Disorders	8.5%
237	Diabetic Angiopathies	8.5%
238	Paraproteinemias	8.5%
239	Pelger-Huet Anomaly	8.5%
240	Postpericardiotomy Syndrome	8.5%
241	Cerebrovascular Insufficiency	8.5%
242	Vascular Neoplasms	8.5%
243	Spinal Cord Vascular Diseases	8.5%
244	Genomic Instability	8.5%
245	Hemorrhoids	8.5%
246	Thoracic Outlet Syndrome	8.5%
247	Incisional hernia	8.4%
248	Dysmenorrhea	8.4%
249	Failed Back Surgery Syndrome	8.4%
250	Aortic Aneurysm, Abdominal	8.3%
251	Aortic Aneurysm, Thoracic	8.3%
252	Basal Ganglia Hemorrhage	8.3%
253	Blood Coagulation Disorders	8.2%
254	Hemorrhagic Disorders	8.2%
255	Eye pain	8.2%
256	Heart Block	8.2%
257	Tachycardia	8.2%
258	Tachyarrhythmia	8.2%
259	Azotemia	8.2%
260	Sick Sinus Syndrome	8.1%
261	Vasculitis, Central Nervous System	7.9%
262	Hand-Arm Vibration Syndrome	7.6%
263	Hemolytic-Uremic Syndrome	7.5%
264	Hyphema	7.5%
265	Vitreous Hemorrhage	7.5%
266	Optic Neuropathy, Ischemic	7.5%
267	Anterior Ischemic Optic Neuropathy	7.5%
268	Mesenteric vascular insufficiency	7.5%
269	Sinus Arrhythmia	7.5%
270	Atrial Fibrillation	7.5%
271	Atrial Flutter	7.5%
272	Coronary heart disease	7.5%
273	Edema, Cardiac	7.5%
274	Myocardial Infarction	7.5%
275	Ventricular Fibrillation	7.5%
276	Ventricular Flutter	7.5%
277	Parasystole	7.5%
278	Paroxysmal atrial fibrillation	7.5%
279	Bradycardia	7.5%
280	Acute Coronary Syndrome	7.5%
281	Peptic Ulcer Hemorrhage	7.4%
282	Cardiotoxicity	7.4%
283	Sudden infant death syndrome	7.4%
284	Transfusion-Related Acute Lung Injury	7.4%
285	Metrorrhagia	7.4%
286	Angioedema	7.4%
287	Colitis, Ischemic	7.4%
288	Heavy Chain Disease	7.3%
289	Polyarteritis Nodosa	7.3%
290	Takayasu Arteritis	7.3%
291	Giant Cell Arteritis	7.3%
292	Temporal Arteritis	7.3%
293	Intracranial Arteriosclerosis	7.3%
294	Cerebral Atherosclerosis	7.3%
295	Long QT Syndrome	7.3%
296	Cerebral Arteriosclerosis	7.3%
297	Putaminal Hemorrhage	7%
298	Sickle Cell Trait	7%
299	Angina, Unstable	6.9%
300	Scimitar Syndrome	6.7%
301	Cerebral Thrombosis	6.7%
302	Intracranial Embolism	6.7%
303	Intracranial Thrombosis	6.7%
304	Retinal Hemorrhage	6.6%
305	Kounis Syndrome	6.6%
306	Choroid Hemorrhage	6.6%
307	Melena	6.6%
308	Postpartum Hemorrhage	6.5%
309	May-Thurner Syndrome	6.5%
310	Acute Disease	6.5%
311	Acute-Phase Reaction	6.5%
312	Amenorrhea	6.5%
313	Aneurysm, Dissecting	6.5%
314	Anorexia	6.5%
315	Anoxia	6.5%
316	Arteriosclerosis	6.5%
317	Arteritis	6.5%
318	Chronic disease	6.5%
319	Constipation	6.5%
320	Critical Illness	6.5%
321	Sudden death	6.5%
322	Diarrhea	6.5%
323	Dyspepsia	6.5%
324	Embolism	6.5%
325	Eructation	6.5%
326	Erythromelalgia	6.5%
327	Fat necrosis	6.5%
328	Fever	6.5%
329	Fibromuscular Dysplasia	6.5%
330	Flatulence	6.5%
331	Gangrene	6.5%
332	Graft Occlusion, Vascular	6.5%
333	Granuloma, Plasma Cell	6.5%
334	Halitosis	6.5%
335	Heartburn	6.5%
336	Hiccough	6.5%
337	Hypercalciuria	6.5%
338	Hypercapnia	6.5%
339	Hyperphagia	6.5%
340	Malignant Hypertension	6.5%
341	Iatrogenic Disease	6.5%
342	Multiple Organ Failure	6.5%
343	Nausea	6.5%
344	Oligomenorrhea	6.5%
345	Premenstrual syndrome	6.5%
346	Psychophysiologic Disorders	6.5%
347	Raynaud Disease	6.5%
348	Recurrence	6.5%
349	Retrograde Degeneration	6.5%
350	Retroperitoneal fibrosis	6.5%
351	Serositis	6.5%
352	Subcutaneous Emphysema	6.5%
353	Surgical Wound Dehiscence	6.5%
354	Syndrome	6.5%
355	Thromboembolism	6.5%
356	Thrombosis	6.5%
357	Vomiting	6.5%
358	Wallerian Degeneration	6.5%
359	Hypocapnia	6.5%
360	Essential Hypertension	6.5%
361	Pyogenic granuloma	6.5%
362	Aneurysm, Ruptured	6.5%
363	Iliac Aneurysm	6.5%
364	Dyschezia	6.5%
365	Pulmonary artery stenosis	6.5%
366	Hypoxia	6.5%
367	Disease Progression	6.5%
368	Hyperoxia	6.5%
369	White Coat Hypertension	6.5%
370	Seroma	6.5%
371	Systemic Vasculitis	6.5%
372	Premenstrual Tension	6.5%
373	Delayed Emergence from Anesthesia	6.5%
374	Infant Death	6.5%
375	Lower Urinary Tract Symptoms	6.5%
376	Hypoxemia	6.5%
377	Anastomotic Leak	6.5%
378	Intraoperative Awareness	6.5%
379	Urinoma	6.5%
380	Embolus	6.5%
381	Body Weight	6.5%
382	Gingival Hemorrhage	6.5%
383	Fanconi Anemia	6.5%
384	Primary Myelofibrosis	6.5%
385	Agranulocytosis	6.5%
386	Anemia, Megaloblastic	6.5%
387	Lymphocytosis	6.5%
388	Myelofibrosis	6.5%
389	Myeloid Metaplasia	6.5%
390	Hypoalbuminemia	6.5%
391	Hypereosinophilic syndrome	6.5%
392	bone marrow fibrosis	6.5%
393	Thrombotic Microangiopathies	6.5%
394	Phantom pain	6.5%
395	Phantom Limb Pain	6.5%
396	Hematoma, Subdural, Spinal	6.5%
397	Lemierre Syndrome	6.5%
398	Abdomen, Acute	6.5%
399	Brain Infarction	6.5%
400	Subarachnoid Hemorrhage, Traumatic	6.4%
401	Carotid Artery, Internal, Dissection	6.4%
402	CREST Syndrome	6.2%
403	Embolism, Amniotic Fluid	6.2%
404	Petechiae	6.1%
405	Purpura	6.1%
406	Infarction, Middle Cerebral Artery	6.1%
407	Infarction, Anterior Cerebral Artery	6.1%
408	Infarction, Posterior Cerebral Artery	6.1%
409	Hoarseness	6%
410	Atypical Hemolytic Uremic Syndrome	5.9%
411	Vertebral Artery Dissection	5.9%
412	Angina Pectoris, Variant	5.8%
413	Acute Chest Syndrome	5.8%
414	Asphyxia	5.8%
415	Granuloma, Respiratory Tract	5.8%
416	Shock, Traumatic	5.8%
417	Chromosome Fragility	5.8%
418	Sinus Thrombosis, Intracranial	5.7%
419	Muscular Atrophy	5.7%
420	Endotoxic shock	5.7%
421	Septic Shock	5.7%
422	Toxic Shock Syndrome	5.7%
423	Adams-Stokes Syndrome	5.7%
424	Atrioventricular Block	5.7%
425	Bundle-Branch Block	5.7%
426	Atrial Premature Complexes	5.7%
427	Sinoatrial Block	5.7%
428	Tachycardia, Paroxysmal	5.7%
429	Supraventricular tachycardia	5.7%
430	Tachycardia, Ventricular	5.7%
431	Tachycardia, Reciprocating	5.7%
432	Apnea	5.7%
433	Cheyne-Stokes Respiration	5.7%
434	Decerebrate State	5.7%
435	Disease susceptibility	5.7%
436	Dyspnea	5.7%
437	Fetal Death	5.7%
438	Foreign-Body Reaction	5.7%
439	Cardiomegaly	5.7%
440	Hemiparesis	5.7%
441	Hyperventilation	5.7%
442	Meningism	5.7%
443	Mouth Breathing	5.7%
444	Neoplasm Invasiveness	5.7%
445	Neoplasm Metastasis	5.7%
446	Neoplasm Recurrence, Local	5.7%
447	Paresis	5.7%
448	Prosthesis Failure	5.7%
449	Retinal Artery Occlusion	5.7%
450	Seizures	5.7%
451	Sensation Disorders	5.7%
452	Sneezing	5.7%
453	Complex partial seizures	5.7%
454	Injection Site Reaction	5.7%
455	Retinal Vasculitis	5.7%
456	Hypertensive Retinopathy	5.7%
457	Tachypnea	5.7%
458	Monoparesis	5.7%
459	Aseptic Necrosis of Bone	5.7%
460	Peritoneal Fibrosis	5.7%
461	Carcinogenesis	5.7%
462	Neurogenic Inflammation	5.7%
463	Perinatal death	5.7%
464	Gait Disorders, Neurologic	5.7%
465	Neuromuscular Manifestations	5.7%
466	Infusion site reaction	5.7%
467	Cardiac Hypertrophy	5.7%
468	Nephrogenic Fibrosing Dermopathy	5.7%
469	Corneal Endothelial Cell Loss	5.7%
470	Encapsulating Peritoneal Sclerosis	5.7%
471	Suppuration	5.7%
472	Nephrogenic Systemic Fibrosis	5.7%
473	Metastasis	5.7%
474	Lymphopenia	5.6%
475	Heart Diseases	5.6%
476	Anterior Compartment Syndrome	5.6%
477	Dental Pulp Necrosis	5.6%
478	Mental Fatigue	5.6%
479	Granuloma, Foreign-Body	5.6%
480	Hirsutism	5.6%
481	Mediastinal Emphysema	5.6%
482	Surgical Wound Infection	5.6%
483	Vasculitis, Leukocytoclastic, Cutaneous	5.6%
484	Gastric Antral Vascular Ectasia	5.6%
485	Facies	5.6%
486	Embryo Loss	5.6%
487	Abdominal Compartment Syndrome	5.6%
488	Orthostatic intolerance	5.6%
489	Hypoventilation	5.6%
490	Afferent Loop Syndrome	5.6%
491	Carotid Artery Diseases	5.6%
492	Brain Ischemia	5.6%
493	Hypotension, Orthostatic	5.6%
494	Sex Chromosome Aberrations	5.6%
495	Short Bowel Syndrome	5.6%
496	Cerebrovascular accident	5.6%
497	Varicose Ulcer	5.6%
498	Sudden Cardiac Death	5.6%
499	Vasospasm, Intracranial	5.6%
500	Spinal Cord Ischemia	5.6%
501	Intracranial Arterial Diseases	5.6%
502	Post-Exercise Hypotension	5.6%
503	Job Syndrome	5.6%
504	Body Weight Changes	5.6%
505	Leukemia, Myelomonocytic, Chronic	5.6%
506	Coronary Occlusion	5.6%
507	Microvascular Angina	5.6%
508	Coronary Stenosis	5.6%
509	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.6%
510	ST segment elevation myocardial infarction	5.6%
511	Adenitis	5.5%
512	Calculi	5.5%
513	Hernia	5.5%
514	Histiocytosis	5.5%
515	Hypertrophy	5.5%
516	Lymphadenitis	5.5%
517	Lymphangitis	5.5%
518	Lymphedema	5.5%
519	Nails, Malformed	5.5%
520	polyps	5.5%
521	Rupture, Spontaneous	5.5%
522	Splenic Diseases	5.5%
523	Thymus Hyperplasia	5.5%
524	Enterocele	5.5%
525	Pseudolymphoma	5.5%
526	Atheroma	5.5%
527	Lymphadenopathy	5.5%
528	Stenosis	5.5%
529	Facial asymmetry	5.5%
530	Plaque, Amyloid	5.5%
531	Plaque, Atherosclerotic	5.5%
532	Cerebral Infarction	5.3%
533	Brain Stem Infarctions	5.3%
534	Carotid Artery Injuries	5.3%
535	Cavernous Sinus Thrombosis	5.3%
536	Sagittal Sinus Thrombosis	5.3%
537	Purpura, Hyperglobulinemic	5.2%
538	Trisomy	5.2%
539	Sleep Wake Disorders	5.2%
540	Tinea Pedis	5.2%
541	Sinus Arrest, Cardiac	5.1%
542	Pupil Disorders	5.1%
543	Neurobehavioral Manifestations	5.1%
544	Signs and Symptoms	5.1%
545	Gait Ataxia	5%
546	Drowning	5%
547	Romano-Ward Syndrome	5%
548	Fetal Growth Retardation	5%
549	Mesenteric Vascular Occlusion	5%
550	Pleural Rub	5%
551	Rales	5%
552	Respiratory Sounds	5%
553	Rhonchi	5%
554	Stridor	5%
555	Wheezing	5%
556	Asterixis	5%
557	Ballismus	5%
558	DNA Degradation, Necrotic	5%
559	Aneuploidy	4.9%
560	Diabetic Retinopathy	4.9%
561	Polyploidy	4.9%
562	Sturge-Weber Syndrome	4.9%
563	Vertigo	4.9%
564	Eosinophilia-Myalgia Syndrome	4.9%
565	Microsatellite Instability	4.9%
566	Lymphangiectasis, Intestinal	4.9%
567	Pain	4.9%
568	Ache	4.9%
569	Cicatrix	4.9%
570	Dyspnea, Paroxysmal	4.9%
571	Chronic granulomatous disease	4.9%
572	Renal hypertension	4.9%
573	Oliguria	4.9%
574	Polyuria	4.9%
575	Proteinuria	4.9%
576	Renal Artery Obstruction	4.9%
577	Renal Artery Stenosis	4.9%
578	Granuloma Annulare	4.9%
579	Chromosome Breakage	4.9%
580	Brain Death	4.9%
581	Basal Ganglia Cerebrovascular Disease	4.9%
582	Vascular Headaches	4.9%
583	Arteriosclerosis Obliterans	4.9%
584	Atherosclerosis	4.9%
585	Air Embolism	4.9%
586	Endarteritis	4.9%
587	Venous Thrombosis	4.9%
588	Deep Vein Thrombosis	4.9%
589	Venous Thromboembolism	4.9%
590	Cyst	4.9%
591	Pregnancy Complications, Cardiovascular	4.9%
592	Cardiovascular Abnormalities	4.9%
593	Neutropenia	4.9%
594	Underweight	4.9%
595	Overweight	4.9%
596	Lateral Medullary Syndrome	4.8%
597	Leukoplakia	4.8%
598	Lymphocele	4.8%
599	Lymphoproliferative Disorders	4.8%
600	Lymphatic Abnormalities	4.8%
601	Airway Remodeling	4.8%
602	Ventricular Remodeling	4.7%
603	Thymus Neoplasms	4.7%
604	Alopecia	4.7%
605	Androgenetic Alopecia	4.7%
606	Coronary Restenosis	4.6%
607	Akathisia	4.6%
608	Restlessness	4.6%
609	Psychomotor Agitation	4.6%
610	Voice Disorders	4.5%
611	Voice Disturbance	4.5%
612	Giant Cell Epulis	4.4%
613	Tachycardia, Atrioventricular Nodal Reentry	4.4%
614	Tachycardia, Ectopic Atrial	4.4%
615	Tachycardia, Ectopic Junctional	4.4%
616	Sinus Tachycardia	4.4%
617	Torsades de Pointes	4.4%
618	Accelerated Idioventricular Rhythm	4.4%
619	Gagging	4.4%
620	Ischemic contracture	4.4%
621	Angioedemas, Hereditary	4.4%
622	Tricuspid Atresia	4.4%
623	Arrhythmogenic Right Ventricular Dysplasia	4.4%
624	Leukomalacia, Periventricular	4.3%
625	POEMS Syndrome	4.3%
626	Tissue Adhesions	4.3%
627	Back Pain	4.3%
628	Bulimia	4.3%
629	Neck Pain	4.3%
630	Chest Pain	4.3%
631	Dizziness	4.3%
632	Dysuria	4.3%
633	Facial Pain	4.3%
634	Fever of Unknown Origin	4.3%
635	Flank Pain	4.3%
636	Headache	4.3%
637	Nocturia	4.3%
638	Pain, Intractable	4.3%
639	Pelvic Pain	4.3%
640	Snoring	4.3%
641	Chronic pain	4.3%
642	Diabetic Foot	4.3%
643	Lightheadedness	4.3%
644	Pain, Referred	4.3%
645	Prostatism	4.3%
646	Throbbing Headache	4.3%
647	Labor Pain	4.3%
648	Cancer Pain	4.3%
649	Nociceptive Pain	4.3%
650	Micronuclei, Chromosome-Defective	4.3%
651	Pulmonary Embolism	4.2%
652	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4.2%
653	Pulmonary Eosinophilia	4.2%
654	Eosinophilic Pneumonia	4.2%
655	Gait Apraxia	4.2%
656	Cerebral Arterial Diseases	4.2%
657	Vertebrobasilar Insufficiency	4.2%
658	Anterior Spinal Artery Syndrome	4.2%
659	Basilar Artery Stenosis	4.2%
660	Vertebral Artery Stenosis	4.2%
661	Intracranial Hemorrhage, Hypertensive	4.2%
662	Transient Cerebral Ischemia	4.2%
663	Leukemia, Myeloid, Chronic-Phase	4.1%
664	Anemia, Pernicious	4.1%
665	Diverticulum	4.1%
666	Diverticulosis	4.1%
667	Sarcopenia	4%
668	Febrile Neutropenia	4%
669	Dementia, Vascular	4%
670	Subacute Combined Degeneration	4%
671	Jet Lag Syndrome	3.9%
672	Reflex, Abnormal	3.9%
673	Hyporeflexia	3.9%
674	Hyperreflexia	3.9%
675	Shy-Drager Syndrome	3.9%
676	Birth Weight	3.9%
677	Cross Infection	3.8%
678	Retinal Neovascularization	3.8%
679	Septicemia	3.8%
680	Sepsis	3.8%
681	Morning Sickness	3.8%
682	Aortic Valve Stenosis	3.7%
683	Cardiomyopathy, Dilated	3.7%
684	Pulmonary Valve Stenosis	3.7%
685	Abscess	3.7%
686	Anosmia	3.7%
687	Ataxia	3.7%
688	Athetosis	3.7%
689	Catalepsy	3.7%
690	Dystonia	3.7%
691	Empyema	3.7%
692	Femur Head Necrosis	3.7%
693	Fetal Resorption	3.7%
694	Hemiplegia	3.7%
695	Locked-In Syndrome	3.7%
696	Lymphatic Metastasis	3.7%
697	Muscle Hypertonia	3.7%
698	Muscle hypotonia	3.7%
699	Myoclonus	3.7%
700	Myotonia	3.7%
701	Neoplasms, Unknown Primary	3.7%
702	Neuralgia	3.7%
703	Paraplegia	3.7%
704	Pseudobulbar Palsy	3.7%
705	Quadriplegia	3.7%
706	Spasm	3.7%
707	Spastic Paraplegia	3.7%
708	Status Epilepticus	3.7%
709	Taste Disorders	3.7%
710	Tremor	3.7%
711	Monoplegia	3.7%
712	Hypokinesia	3.7%
713	Left Ventricular Hypertrophy	3.7%
714	Gastroparesis	3.7%
715	Leukemic Infiltration	3.7%
716	Right Ventricular Hypertrophy	3.7%
717	Paraparesis	3.7%
718	Bradykinesia	3.7%
719	Waxy flexibility	3.7%
720	Action Tremor	3.7%
721	Resting Tremor	3.7%
722	Dysosmia	3.7%
723	Quadriparesis	3.7%
724	Premenstrual Dysphoric Disorder	3.7%
725	Olfaction Disorders	3.7%
726	Choroidal Neovascularization	3.7%
727	Myokymia	3.7%
728	Somatosensory Disorders	3.7%
729	Neoplasm Micrometastasis	3.7%
730	Neuropathic pain	3.7%
731	Hyperkinesia	3.7%
732	Intention tremor	3.7%
733	Dumping Syndrome	3.7%
734	Bacterial Endocarditis	3.7%
735	Cicatrix, Hypertrophic	3.7%
736	Weight Gain	3.7%
737	Lupus Vasculitis, Central Nervous System	3.6%
738	Hypertension, Renovascular	3.6%
739	Hypoxia-Ischemia, Brain	3.6%
740	Hereditary Angioedema Type III	3.6%
741	Hereditary Angioedema Types I and II	3.6%
742	Behcet Syndrome	3.6%
743	Alice in Wonderland Syndrome	3.5%
744	Hepatic Vein Thrombosis	3.5%
745	Budd-Chiari Syndrome	3.5%
746	Pulmonary Infarction	3.5%
747	Subclavian Steal Syndrome	3.5%
748	Vision Disorders	3.3%
749	Metamorphopsia	3.3%
750	Visual Impairment	3.3%
751	Ataxia Telangiectasia	3.3%
752	Metatarsalgia	3.3%
753	Cardiac Tamponade	3.3%
754	Endocarditis	3.3%
755	Cardiac Arrest	3.3%
756	Heart failure	3.3%
757	Pericardial effusion	3.3%
758	Pericarditis	3.3%
759	Pneumopericardium	3.3%
760	Cor pulmonale	3.3%
761	Ventricular Outflow Obstruction	3.3%
762	Ventricular Dysfunction	3.3%
763	Cardiomyopathies	3.3%
764	Pleuropericarditis	3.3%
765	Anisocoria	3.3%
766	Confusion	3.3%
767	Facial paralysis	3.3%
768	Lethargy	3.3%
769	Memory Disorders	3.3%
770	Muscle Cramp	3.3%
771	Perceptual Disorders	3.3%
772	Psychomotor Disorders	3.3%
773	Tonic Pupil	3.3%
774	Anhedonia	3.3%
775	Disorientation	3.3%
776	Fetal Hypoxia	3.3%
777	Facial Paresis	3.3%
778	Memory Loss	3.3%
779	Hemisensory Neglect	3.3%
780	Dysacusis	3.3%
781	Aortic coarctation	3.3%
782	Cor Triatriatum	3.3%
783	Coronary Vessel Anomalies	3.3%
784	Patent ductus arteriosus	3.3%
785	Ebstein Anomaly	3.3%
786	Heart Septal Defects	3.3%
787	Mastodynia	3.3%
788	Respiratory Paralysis	3.3%
789	Tetralogy of Fallot	3.3%
790	Transposition of Great Vessels	3.3%
791	Hypoplastic Left Heart Syndrome	3.3%
792	Elephantiasis	3.3%
793	Diaphragmatic Hernia	3.3%
794	Hypersplenism	3.3%
795	Intestinal Polyps	3.3%
796	Pituitary Apoplexy	3.3%
797	Sarcoidosis	3.3%
798	Splenomegaly	3.3%
799	Elephantiasis Nostras Verrucosa	3.3%
800	Chorea	3.3%
801	Keloid	3.3%
802	Tetany	3.3%
803	Urinary Incontinence	3.3%
804	Breakthrough Pain	3.3%
805	Monosomy	3.2%
806	Tetraploidy	3.2%
807	Stillbirth	3.2%
808	Fetal Weight	3.2%
809	Emaciation	3.2%
810	Low Back Pain	3.2%
811	Visceral Pain	3.2%
812	Albuminuria	3.2%
813	Hemoglobinuria	3.2%
814	Alexia	3.2%
815	Dyslexia	3.2%
816	Granulomatosis with polyangiitis	3.1%
817	Cerebral Amyloid Angiopathy	3%
818	Hypertrophic Cardiomyopathy	3%
819	Hypertrophic obstructive cardiomyopathy	3%
820	Consciousness Disorders	3%
821	Mental Retardation	3%
822	Depressed Level of Consciousness	3%
823	Mental deficiency	3%
824	Intellectual Disability	3%
825	Rheumatoid Vasculitis	2.9%
826	Catatonia	2.9%
827	Cellulitis	2.9%
828	Musculoskeletal Pain	2.9%
829	Ophthalmoplegia	2.9%
830	External Ophthalmoplegia	2.9%
831	Aphonia	2.9%
832	Arthralgia	2.9%
833	Dextrocardia	2.9%
834	Sleep Deprivation	2.9%
835	Polyarthralgia	2.9%
836	Dysphonia	2.9%
837	Cerebrospinal Fluid Otorrhea	2.9%
838	Cerebrospinal Fluid Rhinorrhea	2.9%
839	Respiratory Tract Fistula	2.9%
840	Obesity	2.9%
841	Viremia	2.9%
842	Parasitemia	2.9%
843	Hepatomegaly	2.8%
844	Histiocytic Disorders, Malignant	2.8%
845	Parovarian Cyst	2.8%
846	Spermatocele	2.8%
847	Splenic Neoplasms	2.8%
848	Oral Fistula	2.8%
849	Cutaneous Fistula	2.8%
850	Rheumatic Heart Disease	2.8%
851	Toothache	2.8%
852	Histiocytosis, Langerhans-Cell	2.8%
853	Tumor Lysis Syndrome	2.8%
854	Vaginal Fistula	2.8%
855	Rectocele	2.8%
856	Hyperemesis Gravidarum	2.8%
857	Supravalvular aortic stenosis	2.8%
858	Lown-Ganong-Levine Syndrome	2.8%
859	Dysgeusia	2.8%
860	Formication	2.8%
861	Hyperalgesia	2.8%
862	Hyperesthesia	2.8%
863	Hypesthesia	2.8%
864	Language Disorders	2.8%
865	Numbness	2.8%
866	Paresthesia	2.8%
867	Paraparesis, Spastic	2.8%
868	Trismus	2.8%
869	Epilepsia Partialis Continua	2.8%
870	Hypogeusia	2.8%
871	Brown-Sequard Syndrome	2.8%
872	Lockjaw	2.8%
873	Allodynia	2.8%
874	Ageusia	2.8%
875	Hemorrhage	2.7%
876	Skin Manifestations	2.7%
877	Cachexia	2.7%
878	Granuloma, Laryngeal	2.7%
879	Sezary Syndrome	2.7%
880	Vocal Cord Paralysis	2.7%
881	Nasal Polyps	2.5%
882	Splenic Rupture	2.5%
883	Lymphoma	2.5%
884	Bacteremia	2.5%
885	Cell Transformation, Viral	2.5%
886	Diplopia	2.5%
887	Muscle Rigidity	2.5%
888	Muscle Spasticity	2.5%
889	Scotoma	2.5%
890	Photophobia	2.5%
891	Cogwheel Rigidity	2.5%
892	Hemifacial Spasm	2.5%
893	Amaurosis	2.5%
894	Blindness	2.5%
895	Nuchal Rigidity	2.5%
896	Meningocele	2.4%
897	Thymoma	2.4%
898	Urinary Calculi	2.4%
899	Encephalocele	2.4%
900	Fungemia	2.4%
901	Agnosia	2.4%
902	Apraxias	2.4%
903	Hallucinations	2.4%
904	Hemianopsia	2.4%
905	Hyperacusis	2.4%
906	Tinnitus	2.4%
907	Visual Agnosia	2.4%
908	Anosognosia	2.4%
909	Wernicke-Korsakoff Syndrome	2.4%
910	Phonophobia	2.4%
911	Hearing Loss	2.4%
912	Wolff-Parkinson-White Syndrome	2.4%
913	Aortopulmonary Septal Defect	2.4%
914	Cerebellar Ataxia	2.4%
915	Double Outlet Right Ventricle	2.4%
916	Endocardial Cushion Defects	2.4%
917	Torticollis	2.4%
918	Myocardial bridging	2.4%
919	Aorticopulmonary Septal Defect	2.4%
920	Sciatica	2.4%
921	Urge Incontinence	2.4%
922	Tardive Dyskinesia	2.4%
923	Dyskinesia, Drug-Induced	2.4%
924	Noonan Syndrome	2.4%
925	Alcohol Withdrawal Seizures	2.4%
926	Philadelphia Chromosome	2.3%
927	Agraphia	2.3%
928	Anomia	2.3%
929	Cluttering	2.3%
930	Language Development Disorders	2.3%
931	Speech Disorders	2.3%
932	Syncope	2.3%
933	Stupor	2.3%
934	Dysgraphia	2.3%
935	Presyncope	2.3%
936	Dyslalia	2.3%
937	Subacute Bacterial Endocarditis	2.3%
938	Vesicovaginal Fistula	2.3%
939	Autoimmune Lymphoproliferative Syndrome	2.2%
940	Marfan Syndrome	2.2%
941	Amblyopia	2.2%
942	Amnesia	2.2%
943	Delirium	2.2%
944	Horner Syndrome	2.2%
945	Dissociative Amnesia	2.2%
946	Color blindness	2.2%
947	Global Amnesia	2.2%
948	Leukoplakia, Oral	2.2%
949	Aortic Valve Insufficiency	2.2%
950	Restrictive cardiomyopathy	2.2%
951	Endocardial Fibroelastosis	2.2%
952	Heart Rupture, Post-Infarction	2.2%
953	Mitral Valve Insufficiency	2.2%
954	Mitral Valve Stenosis	2.2%
955	Myocarditis	2.2%
956	Pericarditis, Constrictive	2.2%
957	Pulmonary Valve Insufficiency	2.2%
958	Tricuspid Valve Insufficiency	2.2%
959	Tricuspid Valve Stenosis	2.2%
960	Ventricular Dysfunction, Left	2.2%
961	Right Ventricular Dysfunction	2.2%
962	Endomyocardial Fibrosis	2.2%
963	Carditis	2.2%
964	Heart Failure, Systolic	2.2%
965	Heart Failure, Diastolic	2.2%
966	Colonic Polyps	2.2%
967	Lymphohistiocytosis, Hemophagocytic	2.2%
968	Erdheim-Chester Disease	2.2%
969	Carcinoid Heart Disease	2.2%
970	Shoulder Pain	2.2%
971	Pediatric Obesity	2.1%
972	MELAS Syndrome	2.1%
973	Aphasia	2.1%
974	Articulation Disorders	2.1%
975	Echolalia	2.1%
976	Stuttering	2.1%
977	Dysphasia	2.1%
978	Endotoxemia	2%
979	Amaurosis Fugax	2%
980	Blindness, Cortical	2%
981	Dyscalculia	2%
982	Brain Hemorrhage, Traumatic	2%
983	Deafness	2%
984	Hearing Loss, Sudden	2%
985	Gerstmann Syndrome	2%
986	Hearing Loss, Bilateral	2%
987	Hearing Loss, High-Frequency	2%
988	Hearing Loss, Mixed Conductive-Sensorineural	2%
989	Prosopagnosia	2%
990	Apraxia, Ideomotor	2%
991	Persistent Vegetative State	2%
992	Charles Bonnet Syndrome	2%
993	Hearing Loss, Unilateral	2%
994	Complete Hearing Loss	2%
995	Alien Hand Syndrome	2%
996	Deaf Mutism	2%
997	Truncus Arteriosus, Persistent	2%
998	Akathisia, Drug-Induced	2%
999	Myalgia	2%
1000	Dysarthria	2%
1001	Kearns-Sayre syndrome	1.9%
1002	Biliary Fistula	1.9%
1003	Gastric Fistula	1.9%
1004	Congenital diaphragmatic hernia	1.9%
1005	Diabetic Cardiomyopathies	1.9%
1006	Cardiomyopathy, Alcoholic	1.9%
1007	Dental Fistula	1.9%
1008	Ectopia Cordis	1.9%
1009	Malignant histiocytosis	1.9%
1010	Oroantral Fistula	1.9%
1011	Sarcoidosis, Pulmonary	1.9%
1012	Histiocytic sarcoma	1.9%
1013	Single umbilical artery	1.9%
1014	Chagas Cardiomyopathy	1.9%
1015	Rectal Prolapse	1.9%
1016	Uterine Prolapse	1.9%
1017	Vaginal Prolapse	1.9%
1018	Mutism	1.8%
1019	Selective Mutism	1.8%
1020	Retrograde amnesia	1.8%
1021	Amnesia, Anterograde	1.8%
1022	Auditory Perceptual Disorders	1.8%
1023	Alexia, Pure	1.7%
1024	Fabry Disease	1.7%
1025	Bronchial Fistula	1.7%
1026	Pancreatic Fistula	1.7%
1027	Intestinal Fistula	1.6%
1028	Gastroschisis	1.6%
1029	Enterocutaneous Fistula	1.6%
1030	Ophthalmoplegic Migraine	1.6%
1031	Salivary Gland Fistula	1.6%
1032	Splenosis	1.6%
1033	Progressive supranuclear palsy	1.6%
1034	Cystocele	1.6%
1035	Hodgkin Disease	1.6%
1036	Lymphoma, Non-Hodgkin	1.6%
1037	Amnesia, Transient Global	1.6%
1038	Aortic Valve Prolapse	1.6%
1039	Tricuspid Valve Prolapse	1.6%
1040	Takotsubo Cardiomyopathy	1.6%
1041	Leukemia, T-Cell	1.6%
1042	Leukemia, B-Cell	1.6%
1043	Candidemia	1.6%
1044	Dural Arteriovenous Fistula	1.5%
1045	Composite Lymphoma	1.4%
1046	Lymphangioleiomyomatosis	1.4%
1047	Turner Syndrome	1.4%
1048	Umbilical hernia	1.4%
1049	Urinary Bladder Fistula	1.3%
1050	Lymphoma, Follicular	1.2%
1051	T-Cell Lymphoma	1.2%
1052	Mantle cell lymphoma	1.2%
1053	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
1054	Leukemia, Large Granular Lymphocytic	1.2%
1055	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
1056	Kartagener Syndrome	1.2%
1057	Rectal Fistula	1.1%
1058	Anal Fistula	1.1%
1059	Kidney Calculi	1.1%
1060	Ureteral Calculi	1.1%
1061	Lymphoma, T-Cell, Cutaneous	1%
1062	Lymphoma, AIDS-Related	1%
1063	Enteropathy-Associated T-Cell Lymphoma	1%
1064	Primary Effusion Lymphoma	1%
1065	Williams Syndrome	0.9%
1066	Lymphomatoid Granulomatosis	0.9%
1067	Mycosis Fungoides	0.9%
1068	Lymphomatoid Papulosis	0.9%
1069	Plasmablastic lymphoma	0.9%
1070	Burkitt Lymphoma	0.8%
1071	Niemann-Pick Disease, Type C	0.6%

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