MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Blue Toe Syndrome

(UMLS:C0242645)

Definition:: A condition that is caused by recurring atheroembolism in the lower extremities. It is characterized by cyanotic discoloration of the toes, usually the first, fourth, and fifth toes. Discoloration may extend to the lateral aspect of the foot. Despite the gangrene-like appearance, blue toes may respond to conservative therapy without amputation.
UMLS ID:: C0242645
MeSH ID:: D018438

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.355.350.454.500.200|C14.907.617.249

Synonym(s)

Blue Toe Syndrome

Blue toe syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Warfarin	FAERS: 37 Canada Vigilance: 1	6021781 9487280 15389900	CTD SIDER Canada Vigilance US FAERS
2	Warfarin	FAERS: 10		US FAERS
3	Pregabalin	FAERS: 5		US FAERS
4	apixaban	FAERS: 5		US FAERS
5	Alendronate	FAERS: 3		US FAERS
6	LCZ 696	FAERS: 3		US FAERS
7	Clopidogrel	FAERS: 2		US FAERS
8	Duloxetine Hydrochloride	FAERS: 2		US FAERS
9	Edarbyclor	FAERS: 2		US FAERS
10	Lisdexamfetamine Dimesylate	FAERS: 2		US FAERS
11	Rosiglitazone	FAERS: 2		US FAERS
12	Teriparatide	FAERS: 2		US FAERS
13	Ticlopidine	FAERS: 2		US FAERS
14	Tiotropium Bromide	FAERS: 2		US FAERS
15	rofecoxib	FAERS: 2		OFFSIDES US FAERS
16	Alprostadil	FAERS: 1		US FAERS
17	Aspirin	FAERS: 1		US FAERS
18	Atorvastatin	FAERS: 1		US FAERS
19	Canagliflozin	FAERS: 1		US FAERS
20	Dabigatran	FAERS: 1		US FAERS
21	Everolimus	FAERS: 1		US FAERS
22	Fingolimod Hydrochloride	FAERS: 1		US FAERS
23	Methotrexate	FAERS: 1		US FAERS
24	Nebivolol	FAERS: 1		US FAERS
25	Norethindrone acetate and ethinyl estradiol	FAERS: 1		US FAERS
26	Prasugrel Hydrochloride	FAERS: 1		US FAERS
27	Raloxifene Hydrochloride	FAERS: 1		US FAERS
28	Rivaroxaban	FAERS: 1		US FAERS
29	Roflumilast	FAERS: 1		US FAERS
30	Simvastatin	FAERS: 1		US FAERS
31	Sunitinib	FAERS: 1		US FAERS
32	dabrafenib	FAERS: 1		US FAERS
33	eltrombopag	FAERS: 1		US FAERS
34	empagliflozin	FAERS: 1		US FAERS
35	saxagliptin	FAERS: 1		US FAERS
36	Acebutolol			OFFSIDES
37	Cefaclor			OFFSIDES
38	Chlordiazepoxide			OFFSIDES
39	Clonidine			OFFSIDES
40	Colestipol			OFFSIDES
41	Diflunisal			OFFSIDES
42	Disopyramide			OFFSIDES
43	Famotidine			OFFSIDES
44	Imipramine			OFFSIDES
45	Mycophenolic Acid			OFFSIDES
46	Nizatidine			OFFSIDES
47	Prednisone		2240906	CTD
48	Varenicline			OFFSIDES
49	pilsicainide			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Periphlebitis	43.9%
2	Phlebitis	43.9%
3	Erythromelalgia	37.9%
4	Raynaud Disease	37.9%
5	Postphlebitic Syndrome	35.4%
6	Myocardial Ischemia	34.8%
7	Aneurysm	34.3%
8	Angiomatosis	34.3%
9	Aortic Diseases	34.3%
10	Arterial Occlusive Diseases	34.3%
11	Hyperemia	34.3%
12	Hypotension	34.3%
13	Superior Vena Cava Syndrome	34.3%
14	Telangiectasis	34.3%
15	Vasculitis	34.3%
16	Venous Insufficiency	34.3%
17	Angiodysplasia	34.3%
18	Capillary Leak Syndrome	34.3%
19	Prehypertension	34.3%
20	Thrombophlebitis	32.4%
21	Aortic Aneurysm	30.8%
22	Aortitis	30.8%
23	Leriche Syndrome	30.8%
24	Thromboangiitis Obliterans	30.8%
25	Thromboembolism	30.2%
26	Thrombosis	30.2%
27	Air Embolism	29.9%
28	Retinal Vein Occlusion	29.1%
29	Vascular System Injuries	27%
30	May-Thurner Syndrome	26.8%
31	Compartment syndromes	26.1%
32	Hepatic Veno-Occlusive Disease	26.1%
33	Peliosis Hepatis	26.1%
34	Varicocele	26.1%
35	Cerebrovascular Disorders	25.7%
36	Diabetic Angiopathies	25.7%
37	Reperfusion Injury	25.7%
38	Splenic Infarction	25.7%
39	Cerebrovascular Insufficiency	25.7%
40	Vascular Neoplasms	25.7%
41	Spinal Cord Vascular Diseases	25.7%
42	Vasoplegia	25.7%
43	Hemorrhoids	25.5%
44	Thoracic Outlet Syndrome	25.5%
45	Embolism, Amniotic Fluid	25.2%
46	Malignant Atrophic Papulosis	24.7%
47	Shwartzman Phenomenon	24.5%
48	Intracranial Embolism and Thrombosis	23.7%
49	Myocardial Reperfusion Injury	23.5%
50	Coronary Aneurysm	23.3%
51	Pulmonary Embolism	23%
52	Livedo Reticularis	22.9%
53	Coronary Thrombosis	22.5%
54	Hand-Arm Vibration Syndrome	21.4%
55	Heart Diseases	21.3%
56	Aortic Rupture	20.9%
57	Optic Neuropathy, Ischemic	20.8%
58	Anterior Ischemic Optic Neuropathy	20.8%
59	Mesenteric vascular insufficiency	20.8%
60	Aortic Aneurysm, Abdominal	20.6%
61	Aortic Aneurysm, Thoracic	20.6%
62	Coronary heart disease	20.5%
63	Myocardial Infarction	20.5%
64	Acute Coronary Syndrome	20.5%
65	Carotid Artery Thrombosis	20.5%
66	Aneurysm, Dissecting	20.4%
67	Arteriosclerosis	20.4%
68	Arteritis	20.4%
69	Fibromuscular Dysplasia	20.4%
70	Malignant Hypertension	20.4%
71	Essential Hypertension	20.4%
72	Aneurysm, Ruptured	20.4%
73	Iliac Aneurysm	20.4%
74	Pulmonary artery stenosis	20.4%
75	White Coat Hypertension	20.4%
76	Systemic Vasculitis	20.4%
77	Carotid Stenosis	20.4%
78	Intracranial Aneurysm	20.4%
79	Angioedema	20.3%
80	Colitis, Ischemic	20.2%
81	Embolism and Thrombosis	20.1%
82	Coronary Artery Disease	19.2%
83	Venous Thrombosis	19.1%
84	Deep Vein Thrombosis	19.1%
85	Venous Thromboembolism	19.1%
86	Moyamoya Disease	19%
87	Arteriovenous fistula	18.7%
88	Vasculitis, Central Nervous System	17.8%
89	CREST Syndrome	17.6%
90	Kounis Syndrome	16.7%
91	Polyarteritis Nodosa	16.6%
92	Takayasu Arteritis	16.6%
93	Intracranial Arteriosclerosis	16.4%
94	Cerebral Atherosclerosis	16.4%
95	Cerebral Arteriosclerosis	16.4%
96	Cerebral Thrombosis	16.4%
97	Intracranial Embolism	16.4%
98	Intracranial Thrombosis	16.4%
99	Angina Pectoris	16.3%
100	Lemierre Syndrome	16.3%
101	Pregnancy Complications, Cardiovascular	16%
102	Cardiovascular Abnormalities	16%
103	Retinal Artery Occlusion	15.7%
104	Retinal Vasculitis	15.7%
105	Hypertensive Retinopathy	15.7%
106	Scimitar Syndrome	15.6%
107	Anterior Compartment Syndrome	15.4%
108	Vasculitis, Leukocytoclastic, Cutaneous	15.4%
109	Gastric Antral Vascular Ectasia	15.4%
110	Abdominal Compartment Syndrome	15.4%
111	Carotid Artery Diseases	15.3%
112	Brain Ischemia	15.3%
113	Hypotension, Orthostatic	15.3%
114	Cerebrovascular accident	15.3%
115	Varicose Ulcer	15.3%
116	Vasospasm, Intracranial	15.3%
117	Spinal Cord Ischemia	15.3%
118	Intracranial Arterial Diseases	15.3%
119	Primary Graft Dysfunction	15.3%
120	Post-Exercise Hypotension	15.3%
121	Pulmonary Infarction	15.2%
122	Peripheral Vascular Diseases	14.2%
123	Giant Cell Arteritis	13.8%
124	Temporal Arteritis	13.8%
125	Arteriosclerosis Obliterans	13.7%
126	Atherosclerosis	13.7%
127	Endarteritis	13.7%
128	Coronary Occlusion	13.7%
129	Microvascular Angina	13.7%
130	Coronary Stenosis	13.7%
131	ST segment elevation myocardial infarction	13.7%
132	Brain Infarction	13.7%
133	Embolism	13.1%
134	Embolus	13.1%
135	Sinus Thrombosis, Intracranial	12.8%
136	Mesenteric Vascular Occlusion	12.5%
137	Mucocutaneous Lymph Node Syndrome	12.5%
138	Diabetic Retinopathy	12.4%
139	Sturge-Weber Syndrome	12.4%
140	Renal hypertension	12.3%
141	Renal Artery Obstruction	12.3%
142	Renal Artery Stenosis	12.3%
143	Hemangioma, Cavernous	12.2%
144	Basal Ganglia Cerebrovascular Disease	12.2%
145	Vascular Headaches	12.2%
146	Scurvy	12.1%
147	Vertebral Artery Dissection	11.8%
148	Subarachnoid Hemorrhage, Traumatic	11.5%
149	Carotid Artery, Internal, Dissection	11.5%
150	Cardiac Tamponade	11.4%
151	Endocarditis	11.4%
152	Cardiac Arrest	11.4%
153	Heart failure	11.4%
154	Pericardial effusion	11.4%
155	Pericarditis	11.4%
156	Pneumopericardium	11.4%
157	Cor pulmonale	11.4%
158	Ventricular Outflow Obstruction	11.4%
159	Ventricular Dysfunction	11.4%
160	Cardiomyopathies	11.4%
161	Pleuropericarditis	11.4%
162	Shock, Cardiogenic	11.1%
163	Cavernous Sinus Thrombosis	11%
164	Sagittal Sinus Thrombosis	11%
165	Angina, Unstable	10.9%
166	Blue Toe Syndrome	10.9%
167	Intermittent Claudication	10.6%
168	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.6%
169	Hepatic Vein Thrombosis	10.5%
170	Budd-Chiari Syndrome	10.5%
171	Coronary Restenosis	10.4%
172	Infarction, Middle Cerebral Artery	10.4%
173	Infarction, Anterior Cerebral Artery	10.4%
174	Infarction, Posterior Cerebral Artery	10.4%
175	No-Reflow Phenomenon	10.4%
176	Cerebral Infarction	10.4%
177	Brain Stem Infarctions	10.4%
178	Carotid Artery Injuries	10.3%
179	Ischemic contracture	10.3%
180	Aortic Valve Stenosis	10.3%
181	Cardiomyopathy, Dilated	10.3%
182	Pulmonary Valve Stenosis	10.3%
183	Cerebral Arterial Diseases	10.3%
184	Vertebrobasilar Insufficiency	10.3%
185	Anterior Spinal Artery Syndrome	10.3%
186	Basilar Artery Stenosis	10.3%
187	Vertebral Artery Stenosis	10.3%
188	Intracranial Hemorrhage, Hypertensive	10.3%
189	Transient Cerebral Ischemia	10.3%
190	Angioedemas, Hereditary	10.3%
191	Tricuspid Atresia	10.3%
192	Arrhythmogenic Right Ventricular Dysplasia	10.3%
193	Cryoglobulinemia	10.2%
194	Leukomalacia, Periventricular	10.2%
195	Diabetic Foot	10.1%
196	Bacterial Endocarditis	9.3%
197	Basal Ganglia Hemorrhage	9%
198	Lateral Medullary Syndrome	8.7%
199	Shy-Drager Syndrome	8.7%
200	Cardiac Output, High	8.7%
201	Myocardial Stunning	8.7%
202	Low Cardiac Output Syndrome	8.7%
203	Purpura, Hyperglobulinemic	8.7%
204	Cardiomegaly	8.6%
205	Postpericardiotomy Syndrome	8.6%
206	Cardiac Hypertrophy	8.6%
207	Rheumatic Heart Disease	8.5%
208	Angina Pectoris, Variant	8.3%
209	Heart Block	8.2%
210	Tachycardia	8.2%
211	Tachyarrhythmia	8.2%
212	Hypertension, Renovascular	8.2%
213	Subarachnoid Hemorrhage	8.2%
214	Hypoxia-Ischemia, Brain	8.2%
215	Cerebral Hemorrhage	8.2%
216	Aortic coarctation	8.2%
217	Cor Triatriatum	8.2%
218	Coronary Vessel Anomalies	8.2%
219	Patent ductus arteriosus	8.2%
220	Ebstein Anomaly	8.2%
221	Heart Septal Defects	8.2%
222	Tetralogy of Fallot	8.2%
223	Transposition of Great Vessels	8.2%
224	Hypoplastic Left Heart Syndrome	8.2%
225	Hereditary Angioedema Type III	8.2%
226	Hereditary Angioedema Types I and II	8.2%
227	Subclavian Steal Syndrome	7.8%
228	Behcet Syndrome	7.7%
229	Hypertrophic Cardiomyopathy	7.7%
230	Hypertrophic obstructive cardiomyopathy	7.7%
231	Waldenstrom Macroglobulinemia	7.7%
232	Multiple Myeloma	7.7%
233	Putaminal Hemorrhage	7.1%
234	Dementia, Vascular	7%
235	Ataxia Telangiectasia	7%
236	Pituitary Apoplexy	6.9%
237	Pseudoxanthoma Elasticum	6.9%
238	Supravalvular aortic stenosis	6.9%
239	Lown-Ganong-Levine Syndrome	6.9%
240	Dextrocardia	6.8%
241	Long QT Syndrome	6.8%
242	Aortic Valve Insufficiency	6.8%
243	Restrictive cardiomyopathy	6.8%
244	Endocardial Fibroelastosis	6.8%
245	Heart Rupture, Post-Infarction	6.8%
246	Mitral Valve Insufficiency	6.8%
247	Mitral Valve Stenosis	6.8%
248	Myocarditis	6.8%
249	Pericarditis, Constrictive	6.8%
250	Pulmonary Valve Insufficiency	6.8%
251	Tricuspid Valve Insufficiency	6.8%
252	Tricuspid Valve Stenosis	6.8%
253	Ventricular Dysfunction, Left	6.8%
254	Right Ventricular Dysfunction	6.8%
255	Endomyocardial Fibrosis	6.8%
256	Carditis	6.8%
257	Heart Failure, Systolic	6.8%
258	Heart Failure, Diastolic	6.8%
259	Granulomatosis with polyangiitis	6.4%
260	Lupus Vasculitis, Central Nervous System	6.4%
261	Cerebral Amyloid Angiopathy	6.2%
262	Rheumatoid Vasculitis	5.9%
263	Sick Sinus Syndrome	5.9%
264	Carcinoid Heart Disease	5.5%
265	Adams-Stokes Syndrome	5.5%
266	Atrioventricular Block	5.5%
267	Bundle-Branch Block	5.5%
268	Atrial Premature Complexes	5.5%
269	Sinoatrial Block	5.5%
270	Tachycardia, Paroxysmal	5.5%
271	Supraventricular tachycardia	5.5%
272	Tachycardia, Ventricular	5.5%
273	Wolff-Parkinson-White Syndrome	5.5%
274	Tachycardia, Reciprocating	5.5%
275	Aortopulmonary Septal Defect	5.5%
276	Double Outlet Right Ventricle	5.5%
277	Endocardial Cushion Defects	5.5%
278	Myocardial bridging	5.5%
279	Aorticopulmonary Septal Defect	5.5%
280	Noonan Syndrome	5.2%
281	Sinus Arrhythmia	5.1%
282	Atrial Fibrillation	5.1%
283	Atrial Flutter	5.1%
284	Edema, Cardiac	5.1%
285	Ventricular Fibrillation	5.1%
286	Ventricular Flutter	5.1%
287	Parasystole	5.1%
288	Paroxysmal atrial fibrillation	5.1%
289	Bradycardia	5.1%
290	Diabetic Cardiomyopathies	5.1%
291	Cardiomyopathy, Alcoholic	5.1%
292	Ectopia Cordis	5.1%
293	Sudden Cardiac Death	5.1%
294	Left Ventricular Hypertrophy	5.1%
295	Right Ventricular Hypertrophy	5.1%
296	Single umbilical artery	5.1%
297	Chagas Cardiomyopathy	5.1%
298	Subacute Bacterial Endocarditis	4.9%
299	Marfan Syndrome	4.7%
300	Aortic Valve Prolapse	4.6%
301	Tricuspid Valve Prolapse	4.6%
302	Takotsubo Cardiomyopathy	4.6%
303	Romano-Ward Syndrome	4.6%
304	Tachycardia, Atrioventricular Nodal Reentry	4.2%
305	Tachycardia, Ectopic Atrial	4.2%
306	Tachycardia, Ectopic Junctional	4.2%
307	Sinus Tachycardia	4.2%
308	Torsades de Pointes	4.2%
309	Accelerated Idioventricular Rhythm	4.2%
310	Truncus Arteriosus, Persistent	4.2%
311	Dyspnea, Paroxysmal	4.1%
312	Hematoma, Subdural	3.9%
313	Hematoma, Epidural, Cranial	3.9%
314	MELAS Syndrome	3.7%
315	Brain Hemorrhage, Traumatic	3.5%
316	Dural Arteriovenous Fistula	3.5%
317	Sinus Arrest, Cardiac	3.4%
318	Hematoma, Subdural, Intracranial	3.3%
319	Hematoma, Subdural, Chronic	3.3%
320	Hematoma, Subdural, Acute	3.3%
321	Fabry Disease	2.9%
322	Turner Syndrome	2.7%
323	Kartagener Syndrome	2%
324	Williams Syndrome	1.8%
325	Kearns-Sayre syndrome	1.7%

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