MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spondylolysis

(UMLS:C0038018)

Definition:: Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.
UMLS ID:: C0038018
MeSH ID:: D013169

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.900.938.500

Synonym(s)

Spondylolysis

Spondylolysis, site unspecified

spondylolyses

spondylolysis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 7		OFFSIDES US FAERS
2	rofecoxib	FAERS: 4		OFFSIDES US FAERS
3	Isotretinoin	FAERS: 2		US FAERS
4	Atorvastatin	FAERS: 1		US FAERS
5	Betamethasone	FAERS: 1		US FAERS
6	Carbamazepine	FAERS: 1		US FAERS
7	Esomeprazole	FAERS: 1		US FAERS
8	Fosamax plus D	FAERS: 1		US FAERS
9	Pregabalin	FAERS: 1		US FAERS
10	Quetiapine Fumarate	FAERS: 1		US FAERS
11	Sitagliptin Phosphate	FAERS: 1		US FAERS
12	tegaserod	FAERS: 1		US FAERS
13	Baclofen			OFFSIDES
14	Bisoprolol			OFFSIDES
15	Bortezomib			OFFSIDES
16	Cefdinir			OFFSIDES
17	Chlorhexidine			OFFSIDES
18	Dicloxacillin			OFFSIDES
19	Dutasteride			OFFSIDES
20	Erythromycin			OFFSIDES
21	Estradiol			OFFSIDES
22	Fludrocortisone			OFFSIDES
23	Gabapentin			OFFSIDES
24	Gatifloxacin			OFFSIDES
25	Hydralazine			OFFSIDES
26	Ibandronic Acid			OFFSIDES
27	Ketorolac Tromethamine			OFFSIDES
28	Latanoprost			OFFSIDES
29	Levodopa			OFFSIDES
30	Melatonin			OFFSIDES
31	Meloxicam			OFFSIDES
32	Metolazone			OFFSIDES
33	Metronidazole			OFFSIDES
34	Nabumetone			OFFSIDES
35	Nifedipine			OFFSIDES
36	Nortriptyline			OFFSIDES
37	Pamidronate			OFFSIDES
38	Penicillin V			OFFSIDES
39	Potassium			OFFSIDES
40	Pramipexole			OFFSIDES
41	Propafenone			OFFSIDES
42	Ramipril			OFFSIDES
43	Rosiglitazone			OFFSIDES
44	Sertraline			OFFSIDES
45	Sevelamer			OFFSIDES
46	Sevelamer			OFFSIDES
47	Thalidomide		6989723	CTD OFFSIDES
48	Tretinoin			OFFSIDES
49	Vinorelbine			OFFSIDES
50	Zoledronic Acid			OFFSIDES
51	alfuzosin			OFFSIDES
52	cyclobenzaprine			OFFSIDES
53	testosterone 17 beta-cypionate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Spinal Stenosis	34.4%
2	Intervertebral Disc Degeneration	34.4%
3	Bone Diseases, Developmental	25.4%
4	Hyperostosis	25.4%
5	Osteitis	25.4%
6	Osteitis Deformans	25.4%
7	Osteochondrosis	25.4%
8	Spinal Neoplasms	24.8%
9	Spondylitis	24.8%
10	Osteoarthropathy, Secondary Hypertrophic	23%
11	Lordosis	22.6%
12	kyphosis	22.6%
13	Platybasia	21.7%
14	Bone Diseases, Endocrine	18.1%
15	Bone Diseases, Infectious	17.2%
16	Bone neoplasms	17.2%
17	Osteopenia	17.2%
18	Osteochondritis	17.1%
19	Bone Resorption	16.9%
20	Aseptic Necrosis of Bone	16.9%
21	Fasciitis	16.4%
22	Foot Deformities	16.4%
23	Arthropathy	16.4%
24	Discitis	16.1%
25	Gigantism	14.9%
26	Ainhum	14.8%
27	Dysostoses	14.8%
28	Spondylarthropathies	13.4%
29	Tuberculosis, Spinal	12.8%
30	Pectus excavatum	11.8%
31	Contracture	11.5%
32	Fasciitis, Plantar	11.5%
33	Jaw Diseases	11.4%
34	Osteoarthritis, Spine	11.3%
35	Cartilage Diseases	10.8%
36	Foot Diseases	10.8%
37	Myopathy	10.8%
38	Rheumatism	10.8%
39	Chondromalacia	10.8%
40	Pectus carinatum	10.7%
41	Ankylosing spondylitis	10.7%
42	Arthrogryposis	10.3%
43	Multiple Epiphyseal Dysplasia	10.1%
44	Osteochondrodysplasias	10.1%
45	Osteomyelitis	9.9%
46	Osteoporosis	9.9%
47	Periostitis	9.9%
48	Bone Demineralization, Pathologic	9.9%
49	Post-Traumatic Osteoporosis	9.9%
50	Alveolar Bone Loss	9.8%
51	Femur Head Necrosis	9.8%
52	Osteolysis	9.8%
53	Chondrodysplasia Punctata	9.7%
54	Enchondromatosis	9.7%
55	Osteosclerosis	9.7%
56	Kashin-Beck Disease	9.7%
57	Klippel-Feil Syndrome	9.2%
58	Synostosis	9.2%
59	Fibromyalgia	8.5%
60	Polymyalgia Rheumatica	8.5%
61	Arthritis, Psoriatic	8.5%
62	Arthritis	8.5%
63	Bursitis	8.5%
64	Joint Instability	8.5%
65	Metatarsalgia	8.5%
66	Myofascial Pain Syndromes	8.5%
67	Rhabdomyolysis	8.5%
68	Synovitis	8.5%
69	Joint laxity	8.5%
70	Polyarthritis	8.5%
71	Frozen shoulder	8.5%
72	Patellofemoral Pain Syndrome	8.5%
73	Congenital Hypothyroidism	8.3%
74	Eosinophilic Granuloma	8.2%
75	Dwarfism	8%
76	Arthritis, Reactive	7.9%
77	Acromegaly	7.3%
78	Joint Tuberculosis	7.3%
79	Tuberculosis, Osteoarticular	7.3%
80	Bone Tuberculosis	7.3%
81	Craniofacial Dysostosis	7.3%
82	Melorheostosis	7.2%
83	Osteopetrosis	7.2%
84	Rheumatic Fever	6.7%
85	Hip Contracture	6.6%
86	Periarthritis	6.6%
87	Osteoporosis, Postmenopausal	6.5%
88	Gout	6.1%
89	Ischemic contracture	6%
90	Rickets	5.9%
91	Compartment syndromes	5.7%
92	Maxillary Diseases	5.7%
93	Tendinitis	5.7%
94	Tendinopathy	5.7%
95	Temporomandibular Joint Disorders	5.7%
96	Craniosynostosis	5.7%
97	Syndactyly	5.7%
98	Brachycephaly	5.7%
99	Hemarthrosis	5.6%
100	Myositis	5.6%
101	Tietze's Syndrome	5.6%
102	Limb Deformities, Congenital	5.6%
103	Isaacs syndrome	5.6%
104	Craniofacial Abnormalities	5.6%
105	Myotonic Disorders	5.6%
106	Rheumatoid Arthritis	5.4%
107	Juvenile arthritis	5.4%
108	Osteoarthritis, Knee	5.4%
109	Osteogenesis Imperfecta	5%
110	Bunion	4.9%
111	Fibrodysplasia Ossificans Progressiva	4.9%
112	Myoglobinuria	4.9%
113	Myositis Ossificans	4.9%
114	Pseudohypoparathyroidism	4.9%
115	Tenosynovitis	4.9%
116	Sacroiliitis	4.9%
117	Talipes	4.9%
118	Mastoiditis	4.8%
119	Petrositis	4.8%
120	Acrocephalosyndactylia	4.5%
121	Temporomandibular Joint Dysfunction Syndrome	4.5%
122	Medial Tibial Stress Syndrome	4.3%
123	Mitochondrial Myopathies	4.2%
124	Mandibulofacial Dysostosis	4.2%
125	Muscle Cramp	4.2%
126	Eosinophilia-Myalgia Syndrome	4.2%
127	Goldenhar Syndrome	4.2%
128	Gastroschisis	4.2%
129	Poland Syndrome	4.1%
130	Muscle Rigidity	4.1%
131	Muscle Spasticity	4.1%
132	Cogwheel Rigidity	4.1%
133	Nuchal Rigidity	4.1%
134	Rheumatoid Nodule	4.1%
135	Antley-Bixler Syndrome Phenotype	4%
136	Osteomalacia	3.8%
137	Marfan Syndrome	3.8%
138	Arthritis, Gouty	3.8%
139	Rubinstein-Taybi Syndrome	3.7%
140	Basal Cell Nevus Syndrome	3.6%
141	Chronic Fatigue Syndrome	3.5%
142	Palatal Neoplasms	3.5%
143	Nail-Patella Syndrome	3.4%
144	Giant Cell Epulis	3.4%
145	Muscle Weakness	3.4%
146	Arthritis, Infectious	3.4%
147	Congenital clubfoot	3.4%
148	Vertical Talus	3.4%
149	Musculoskeletal Pain	3.3%
150	Jaw Abnormalities	3.3%
151	Familial Periodic Paralysis	3.3%
152	Anterior Compartment Syndrome	3.3%
153	Enthesopathy	3.3%
154	Arthritis, Experimental	3.3%
155	Abdominal Compartment Syndrome	3.3%
156	Arthralgia	3.3%
157	Polyarthralgia	3.3%
158	Felty Syndrome	3.3%
159	Amelia	3.3%
160	Arachnodactyly	3.3%
161	Ectromelia	3.3%
162	Hemimelia	3.3%
163	Phocomelia	3.3%
164	Sirenomelia	3.3%
165	Polymyositis	3.3%
166	Polydactyly	3.3%
167	Brachydactyly	3.3%
168	Plagiocephaly	3.3%
169	Lower Extremity Deformities, Congenital	3.3%
170	Upper Extremity Deformities, Congenital	3.3%
171	Laryngomalacia	2.9%
172	Cockayne Syndrome	2.8%
173	Myalgia	2.7%
174	Rheumatoid Vasculitis	2.7%
175	Prognathism	2.7%
176	Hip Dislocation	2.6%
177	Shoulder Dislocation	2.6%
178	Hip Dysplasia	2.6%
179	Nose Neoplasms	2.5%
180	Muscular Dystrophy	2.5%
181	Orbital Myositis	2.5%
182	Dupuytren Contracture	2.5%
183	Pyomyositis	2.5%
184	Renal Osteodystrophy	2.4%
185	Renal rickets	2.4%
186	Sicca Syndrome	2.3%
187	Sjogren's Syndrome	2.3%
188	Micrognathism	2.1%
189	Pierre Robin Syndrome	2.1%
190	Myotonic Dystrophy	2%
191	Maxillofacial Abnormalities	2%
192	Myotonia Congenita	2%
193	Bronchomalacia	2%
194	Tracheomalacia	2%
195	Microcephaly	1.9%
196	Macrocephaly	1.9%
197	Hypokalemic periodic paralysis	1.9%
198	Shoulder Pain	1.9%
199	Retrognathia	1.8%
200	Mitochondrial Encephalomyopathies	1.6%
201	Welander Distal Myopathy	1.6%
202	Cleft Palate	1.5%
203	Noonan Syndrome	1.4%
204	Dermatomyositis	1.3%
205	Muscular Dystrophy, Duchenne	1.3%
206	Porencephaly	1.3%
207	Holoprosencephaly	1.2%
208	Familial Hypophosphatemic Rickets	1.1%
209	Radicular Cyst	0.8%
210	MELAS Syndrome	0.6%
211	Kearns-Sayre syndrome	0.6%

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