MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Water Intoxication

(UMLS:C0043049)

Definition:: A condition resulting from the excessive retention of water with sodium depletion.
UMLS ID:: C0043049
MeSH ID:: D014869

Classification 1:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.950.932

Classification 2:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.723.932

Synonym(s)

Water Intoxication

WATER INTOXICATION

Water intoxication

Water intoxication syndrome

intoxication; water

water intoxication

water; intoxication

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Risperidone	FAERS: 12 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
2	Deamino Arginine Vasopressin	FAERS: 9		US FAERS
3	Clozapine	FAERS: 7 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Deamino Arginine Vasopressin	FAERS: 7 Canada Vigilance: 1	2273207	CTD OFFSIDES Canada Vigilance US FAERS
5	Hydrochlorothiazide	FAERS: 6		US FAERS
6	Olanzapine	FAERS: 6		OFFSIDES SIDER US FAERS
7	Aripiprazole	FAERS: 4		OFFSIDES US FAERS
8	Paliperidone Palmitate	FAERS: 4		US FAERS
9	Buprenorphine	FAERS: 3		US FAERS
10	Carbamazepine	FAERS: 3	288398 6877534	CTD SIDER US FAERS
11	Deamino Arginine Vasopressin	FAERS: 3		SIDER US FAERS
12	Desmopressin acetate trihydrate	FAERS: 3		US FAERS
13	Omeprazole	FAERS: 3		US FAERS
14	Varenicline	FAERS: 3		US FAERS
15	atovaquone, proguanil drug combination	FAERS: 3		OFFSIDES US FAERS
16	Amiodarone	FAERS: 2		US FAERS
17	Barium Sulfate	FAERS: 2		US FAERS
18	Cyclophosphamide	FAERS: 2	7633237	CTD SIDER US FAERS
19	Paliperidone Palmitate	FAERS: 2		SIDER US FAERS
20	Quetiapine Fumarate	FAERS: 2		SIDER US FAERS
21	ledipasvir, sofosbuvir drug combination	FAERS: 2		US FAERS
22	Atorvastatin	FAERS: 1		US FAERS
23	Cetirizine	FAERS: 1		US FAERS
24	Clomipramine	FAERS: 1		US FAERS
25	Clopidogrel	FAERS: 1		US FAERS
26	Diclofenac	FAERS: 1		US FAERS
27	Duloxetine Hydrochloride	FAERS: 1		US FAERS
28	Esomeprazole	FAERS: 1		US FAERS
29	Galantamine	FAERS: 1		US FAERS
30	Ibuprofen	FAERS: 1		US FAERS
31	Lithium Carbonate	FAERS: 1		US FAERS
32	Methylphenidate	FAERS: 1		US FAERS
33	Oseltamivir	FAERS: 1		US FAERS
34	Oxcarbazepine	FAERS: 1		US FAERS
35	Oxytocin	FAERS: 1		SIDER US FAERS
36	Teriparatide	FAERS: 1		US FAERS
37	Thyroxine	FAERS: 1		US FAERS
38	Tiotropium Bromide	FAERS: 1		US FAERS
39	Trazodone	FAERS: 1		US FAERS
40	Valsartan	FAERS: 1		US FAERS
41	Venlafaxine Hydrochloride	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
42	posaconazole	FAERS: 1		US FAERS
43	ziprasidone	FAERS: 1		US FAERS
44	Allopurinol			SIDER
45	Alosenn			OFFSIDES
46	Biperiden			OFFSIDES
47	Chlorpropamide		4694904	CTD
48	Ergonovine			SIDER
49	Erythromycin			OFFSIDES
50	Flunitrazepam			OFFSIDES
51	Glycerol			OFFSIDES
52	Hydron;carbonate			OFFSIDES
53	Methotrimeprazine			OFFSIDES
54	Methylergonovine			SIDER
55	Nitrazepam			OFFSIDES
56	Nitroglycerin			OFFSIDES
57	Piracetam			OFFSIDES
58	Procyclidine			OFFSIDES
59	Ribavirin			OFFSIDES
60	Sodium Chloride		803783 5067144	CTD
61	Tranexamic Acid			OFFSIDES
62	Triazolam			OFFSIDES
63	Trihexyphenidyl			OFFSIDES
64	benidipine			OFFSIDES
65	cefditoren pivoxil			OFFSIDES
66	cloxazolam			OFFSIDES
67	ethyl loflazepate			OFFSIDES
68	etizolam			OFFSIDES
69	ferrous fumarate			OFFSIDES
70	fluphenazine enanthate		7341545	CTD
71	haloperidol decanoate			OFFSIDES
72	mequitazine			OFFSIDES
73	mosapride			OFFSIDES
74	periciazine			OFFSIDES
75	perospirone			OFFSIDES
76	polystyrene sulfonic acid			OFFSIDES
77	quazepam			OFFSIDES
78	sennoside A&B			OFFSIDES
79	tipepidine			OFFSIDES
80	zotepine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hypercalcemia	33.9%
2	Hypocalcemia	33.9%
3	Milk-Alkali Syndrome	33.9%
4	Hyperkalemia	31.8%
5	Hypernatremia	31.8%
6	Hypokalemia	31.8%
7	Hyponatremia	31.8%
8	Mushroom Poisoning	30.5%
9	Fluoride Poisoning	27.9%
10	Food Poisoning	27.9%
11	Gas Poisoning	27.9%
12	Mycotoxicosis	27.9%
13	Plant Poisoning	27.9%
14	Organophosphate poisoning	27.9%
15	Dehydration	24.1%
16	Chemical and Drug Induced Liver Injury	22.5%
17	Bites and Stings	21.8%
18	Neurotoxicity Syndromes	21.8%
19	Wasting Syndrome	21.1%
20	Acid-Base Imbalance	20.9%
21	Calcium Metabolism Disorders	20.9%
22	Iron Metabolism Disorders	20.9%
23	Phosphorus Metabolism Disorders	20.9%
24	Lipid Metabolism Disorders	20.9%
25	Mitochondrial Diseases	20.9%
26	Glucose Metabolism Disorders	20.9%
27	Arsenic Poisoning	20.7%
28	Cadmium poisoning	20.5%
29	Carbon Monoxide Poisoning	20.5%
30	Ciguatera Poisoning	20.5%
31	Ergotism	20.5%
32	Lead Poisoning	20.5%
33	Mercury Poisoning	20.5%
34	Shellfish Poisoning	20.5%
35	Psychoses, Substance-Induced	18.6%
36	Lipodystrophy	16.2%
37	Chemical and Drug Induced Liver Injury, Chronic	16.2%
38	Osteopenia	15.8%
39	Pseudohypoparathyroidism	15.7%
40	Alcohol-Induced Disorders, Nervous System	15.6%
41	Brain Diseases, Metabolic	15.5%
42	Insect Bites and Stings	15.5%
43	Argyria	15.3%
44	Manganese Poisoning	15.3%
45	Tick Paralysis	15.1%
46	Salmonella food poisoning	15.1%
47	Drug toxicity	14.6%
48	Rickets	14.6%
49	Acidosis	13.6%
50	Alkalosis	13.6%
51	Amyloidosis	13.6%
52	Calcinosis	13.6%
53	Hyperglycemia	13.6%
54	Hyperinsulinism	13.6%
55	Hypoglycemia	13.6%
56	Xanthomatosis	13.6%
57	Hypophosphatemia	13.6%
58	Metabolic acidosis	13.6%
59	Dyslipidemias	13.6%
60	Iron Overload	13.6%
61	Xanthoma	13.6%
62	Leigh Disease	13.6%
63	Brain Diseases, Metabolic, Inborn	13.4%
64	Hyperhomocysteinemia	12.8%
65	Psychoses, Alcoholic	12.8%
66	Akathisia, Drug-Induced	12.7%
67	Mercury Poisoning, Nervous System	12.6%
68	Lead Poisoning, Nervous System	12.6%
69	Carbamoyl-Phosphate Synthase I Deficiency Disease	12.4%
70	Hyperlipoproteinemia Type IV	12.3%
71	Hyperlipoproteinemia Type V	12.3%
72	Neuroleptic Malignant Syndrome	12.2%
73	Nutrition Disorders	12.2%
74	Hypolipoproteinemias	11.9%
75	Lactose Intolerance	11.6%
76	Drug abuse	11.3%
77	Substance Dependence	11.3%
78	Substance-Related Disorders	11.3%
79	Drug Dependence	11.3%
80	Lead Poisoning, Nervous System, Childhood	11.2%
81	Lead Poisoning, Nervous System, Adult	11.2%
82	Smith-Lemli-Opitz Syndrome	11.1%
83	Galactosemias	11%
84	Urea Cycle Disorders, Inborn	11%
85	Tyrosinemias	11%
86	Dyskinesia, Drug-Induced	11%
87	Osteomalacia	11%
88	Diabetic Ketoacidosis	11%
89	Hyperlipidemia, Familial Combined	10.9%
90	Familial Hypophosphatemic Rickets	10.8%
91	Diabetes Mellitus	10.7%
92	Alcohol Withdrawal Delirium	10.6%
93	Alcohol Withdrawal Seizures	10.6%
94	Hyperlipoproteinemia Type III	10.4%
95	Lipomatosis	10.3%
96	Werner Syndrome	10.3%
97	Congenital Hyperinsulinism	10.2%
98	Achlorhydria	10.2%
99	Amino Acid Metabolism, Inborn Errors	10.2%
100	Bloom Syndrome	10.2%
101	Botulism	10.2%
102	Carbohydrate Metabolism, Inborn Errors	10.2%
103	Metal Metabolism, Inborn Errors	10.2%
104	Osteoporosis	10.2%
105	Progeria	10.2%
106	Lysosomal Storage Diseases	10.2%
107	Bone Demineralization, Pathologic	10.2%
108	Cytochrome-c Oxidase Deficiency	10.2%
109	Peroxisomal Disorders	10.2%
110	Post-Traumatic Osteoporosis	10.2%
111	Acidosis, Lactic	10.1%
112	Calciphylaxis	10.1%
113	Hemosiderosis	10.1%
114	Ketosis	10.1%
115	Ketonuria	10.1%
116	Ketoacidosis	10.1%
117	Ketonemia	10.1%
118	Vascular calcification	10.1%
119	Celiac Disease	10.1%
120	Sprue, Tropical	10.1%
121	Steatorrhea	10.1%
122	Sprue	10.1%
123	MPTP Poisoning	10%
124	Gaucher Disease	10%
125	Mitochondrial Encephalomyopathies	10%
126	Hypoalphalipoproteinemias	9.8%
127	Hyperphosphaturia	9.8%
128	Glycogen storage disease type II	9.7%
129	Wernicke Encephalopathy	9.5%
130	Homocystinuria	9.3%
131	Anticholinergic Syndrome	9.3%
132	Serotonin Syndrome	9.3%
133	Propofol Infusion Syndrome	9.3%
134	Tay-Sachs Disease	9%
135	Acrodynia	9%
136	Amyloid Neuropathies, Familial	8.8%
137	Niemann-Pick Disease, Type C	8.6%
138	Renal tubular acidosis	8.4%
139	Hypercholesterolemia	8.4%
140	Hyperlipoproteinemias	8.4%
141	Hypertriglyceridemia	8.4%
142	Nesidioblastosis	8.3%
143	Mitochondrial Myopathies	8.2%
144	Myelinolysis, Central Pontine	8.2%
145	Glycosuria	8.1%
146	Reye Syndrome	8.1%
147	Hepatic Encephalopathy	8%
148	Fabry Disease	7.9%
149	Neuronal Ceroid-Lipofuscinoses	7.8%
150	HIV Wasting Syndrome	7.6%
151	Acidosis, Respiratory	7.6%
152	Adiposis Dolorosa	7.6%
153	Alkalosis, Respiratory	7.6%
154	Adrenoleukodystrophy	7.6%
155	MELAS Syndrome	7.5%
156	Alkaptonuria	7.5%
157	Glycogen Storage Disease	7.5%
158	Hypophosphatasia	7.5%
159	Insulin Resistance	7.5%
160	Osteoporosis, Postmenopausal	7.5%
161	Propionic acidemia	7.5%
162	Dihydropyrimidine Dehydrogenase Deficiency	7.5%
163	Cystinosis	7.5%
164	Zellweger Syndrome	7.4%
165	HIV-Associated Lipodystrophy Syndrome	7.4%
166	Menkes Kinky Hair Syndrome	7.3%
167	Renal Osteodystrophy	7.3%
168	Renal rickets	7.3%
169	Marijuana Abuse	7%
170	Opioid-Related Disorders	7%
171	Nicotine Dependence	7%
172	Opioid abuse	7%
173	Phencyclidine Abuse	7%
174	Substance Abuse, Intravenous	7%
175	Substance Withdrawal Syndrome	7%
176	Tobacco Use Disorder	7%
177	Alcohol-Related Disorders	7%
178	Amphetamine-Related Disorders	7%
179	Cocaine-Related Disorders	7%
180	Metabolic Side Effects of Drugs and Substances	7%
181	Child Nutrition Disorders	7%
182	Hypervitaminosis A	7%
183	Infant Nutrition Disorders	7%
184	Mucopolysaccharidosis III	7%
185	Malnutrition	7%
186	Injection Site Reaction	6.9%
187	Infusion site reaction	6.9%
188	Hepatolenticular Degeneration	6.9%
189	Drug Overdose	6.8%
190	Porphyrias, Hepatic	6.8%
191	Alcohol-Induced Disorders	6.8%
192	Refsum Disease	6.8%
193	Necrobiosis Lipoidica Diabeticorum	6.7%
194	Fanconi Anemia	6.6%
195	Glycosuria, Renal	6.5%
196	Gestational Diabetes	6.2%
197	Latent Autoimmune Diabetes in Adults	6.2%
198	Glycogen Storage Disease Type I	6.2%
199	Glycogen Storage Disease Type V	6.2%
200	Diabetes Mellitus, Experimental	6.1%
201	Nephrocalcinosis	6%
202	Tetany	6%
203	Cerebral Amyloid Angiopathy	5.9%
204	Friedreich Ataxia	5.6%
205	Neonatal Abstinence Syndrome	5.6%
206	Kearns-Sayre syndrome	5.3%
207	Alcohol Use Disorder	5.1%
208	Alcoholic Intoxication	5.1%
209	Heroin Dependence	5.1%
210	Morphine Dependence	5.1%
211	Alcohol abuse	5.1%
212	Kernicterus	5.1%
213	Familial Periodic Paralysis	5.1%
214	Primary amyloidosis	5%
215	Cockayne Syndrome	5%
216	Variegate Porphyria	5%
217	Acute intermittent porphyria	5%
218	Porphyria Cutanea Tarda	5%
219	Renal Aminoacidurias	4.9%
220	Fanconi Syndrome	4.9%
221	Pseudohypoaldosteronism	4.9%
222	Liddle Syndrome	4.9%
223	Sjogren-Larsson Syndrome	4.9%
224	Canavan Disease	4.9%
225	Alexander Disease	4.9%
226	Mucopolysaccharidosis II	4.9%
227	Cardiotoxicity	4.6%
228	Deficiency Diseases	4.5%
229	Starvation	4.5%
230	Refeeding Syndrome	4.5%
231	Ataxia Telangiectasia	4.5%
232	Optic Atrophy, Hereditary, Leber	4.4%
233	Gout	4.3%
234	Amyotrophic Lateral Sclerosis	4.3%
235	Antley-Bixler Syndrome Phenotype	4.2%
236	Cardiomyopathy, Alcoholic	4.2%
237	Pancreatitis, Alcoholic	4.2%
238	Hypokalemic periodic paralysis	4.1%
239	Frontotemporal dementia	4.1%
240	Cystinuria	4.1%
241	Drug Eruptions	4.1%
242	Xeroderma Pigmentosum	4.1%
243	Binge Drinking	4%
244	CREST Syndrome	3.7%
245	Arthritis, Gouty	3.5%
246	Fetal Alcohol Spectrum Disorders	3.4%
247	Kwashiorkor	3.4%
248	Magnesium Deficiency	3.4%
249	Potassium Deficiency	3.4%
250	Protein Deficiency	3.4%
251	Avitaminosis	3.4%
252	Albinism	3.3%
253	Acute Generalized Exanthematous Pustulosis	3.3%
254	Fatty Liver, Alcoholic	3%
255	Hepatitis, Alcoholic	3%
256	Liver Cirrhosis, Alcoholic	3%
257	Asthma, Aspirin-Induced	2.9%
258	Ascorbic Acid Deficiency	2.8%
259	Vitamin A Deficiency	2.8%
260	Vitamin D Deficiency	2.8%
261	Vitamin E Deficiency	2.8%
262	Marasmus	2.8%
263	Erythema Nodosum	2.8%
264	Serum Sickness	2.8%
265	Ichthyosis, X-Linked	2.7%
266	Folic Acid Deficiency	2.5%
267	Pellagra	2.5%
268	Thiamine Deficiency	2.5%
269	Vitamin B 12 Deficiency	2.5%
270	Vitamin B 6 Deficiency	2.5%
271	Pyridoxine Deficiency	2.5%
272	Beriberi	2.4%
273	Obesity	2.2%
274	Toxic Epidermal Necrolysis	2.1%
275	Stevens-Johnson Syndrome	2.1%
276	Obesity, Abdominal	2%
277	Anemia, Pernicious	1.8%
278	Vitamin K Deficiency	1.7%
279	Pediatric Obesity	1.6%
280	Scurvy	1.5%
281	Prader-Willi Syndrome	1.4%
282	Subacute Combined Degeneration	1%

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