MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Fibromuscular Dysplasia

(UMLS:C0016052)

Definition:: An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.
UMLS ID:: C0016052
MeSH ID:: D005352

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.137.372

Synonym(s)

Fibromuscular Dysplasia

ARTERIAL FIBRODYSPLASIA

Arterial fibromuscular dysplasia

Dysplasia, fibromuscular

FIBROMUSCULAR DYSPLASIA

FMD - Fibromuscular dysplasia

Fibromuscular Hyperplasia

Fibromuscular dysplasia

Fibromuscular dysplasia of wall of artery

10.

Fibromuscular hyperplasia

11.

Fibromuscular hyperplasia of artery

12.

Hyperplasia, fibromuscular

13.

arterial fibromuscular dysplasia

14.

fibromuscular arterial hyperplasia

15.

fibromuscular dysplasia

16.

fibromuscular hyperplasia of artery

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	tegaserod	FAERS: 3		OFFSIDES US FAERS
2	4-hydroxybutyric acid	FAERS: 2		US FAERS
3	Sumatriptan	FAERS: 2		US FAERS
4	Aspirin	FAERS: 1		US FAERS
5	Ezetimibe	FAERS: 1		US FAERS
6	Fluoxetine	FAERS: 1		US FAERS
7	Indomethacin	FAERS: 1		US FAERS
8	Methylphenidate	FAERS: 1		US FAERS
9	Prednisone	FAERS: 1		US FAERS
10	Sumatriptan	FAERS: 1		US FAERS
11	eletriptan	FAERS: 1		US FAERS
12	rofecoxib	FAERS: 1		OFFSIDES US FAERS
13	sapropterin	FAERS: 1		US FAERS
14	Cocaine		17868884	CTD
15	Dextropropoxyphene			OFFSIDES
16	Estrogens, Conjugated (USP)			OFFSIDES
17	Medroxyprogesterone			OFFSIDES
18	tegaserod			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Arteriosclerosis	46.7%
2	Pulmonary artery stenosis	46.7%
3	Leriche Syndrome	44.4%
4	Thromboangiitis Obliterans	44.4%
5	Arteriosclerosis Obliterans	34.4%
6	Atherosclerosis	34.4%
7	Malignant Atrophic Papulosis	33.3%
8	Retinal Artery Occlusion	31.8%
9	Aneurysm	31%
10	Angiomatosis	31%
11	Aortic Diseases	31%
12	Hyperemia	31%
13	Hypotension	31%
14	Superior Vena Cava Syndrome	31%
15	Telangiectasis	31%
16	Vasculitis	31%
17	Venous Insufficiency	31%
18	Peripheral Vascular Diseases	31%
19	Embolism and Thrombosis	31%
20	Angiodysplasia	31%
21	Capillary Leak Syndrome	31%
22	Prehypertension	31%
23	Carotid Stenosis	30.2%
24	Myocardial Ischemia	27.9%
25	Coronary Artery Disease	26.8%
26	Aortic Aneurysm	26.7%
27	Aortitis	26.7%
28	Periphlebitis	26.7%
29	Phlebitis	26.7%
30	Intracranial Arteriosclerosis	24.3%
31	Cerebral Atherosclerosis	24.3%
32	Cerebral Arteriosclerosis	24.3%
33	Moyamoya Disease	24%
34	Mesenteric Vascular Occlusion	23.7%
35	Intermittent Claudication	23.6%
36	Renal Artery Obstruction	23.1%
37	Renal Artery Stenosis	23.1%
38	Postphlebitic Syndrome	23.1%
39	Vascular System Injuries	22%
40	Retinal Vein Occlusion	21.7%
41	Compartment syndromes	20.9%
42	Hepatic Veno-Occlusive Disease	20.9%
43	Peliosis Hepatis	20.9%
44	Varicocele	20.9%
45	Thrombophlebitis	20.6%
46	Cerebrovascular Disorders	20.5%
47	Diabetic Angiopathies	20.5%
48	Reperfusion Injury	20.5%
49	Splenic Infarction	20.5%
50	Cerebrovascular Insufficiency	20.5%
51	Vascular Neoplasms	20.5%
52	Spinal Cord Vascular Diseases	20.5%
53	Vasoplegia	20.5%
54	Blue Toe Syndrome	20.4%
55	Hemorrhoids	20.2%
56	Thoracic Outlet Syndrome	20.2%
57	Aneurysm, Dissecting	20%
58	Arteritis	20%
59	Embolism	20%
60	Erythromelalgia	20%
61	Malignant Hypertension	20%
62	Raynaud Disease	20%
63	Thromboembolism	20%
64	Thrombosis	20%
65	Essential Hypertension	20%
66	Aneurysm, Ruptured	20%
67	Iliac Aneurysm	20%
68	White Coat Hypertension	20%
69	Systemic Vasculitis	20%
70	Embolus	20%
71	Shwartzman Phenomenon	19.8%
72	Coronary Aneurysm	19.7%
73	Aortic Aneurysm, Abdominal	19.6%
74	Aortic Aneurysm, Thoracic	19.6%
75	Heart Diseases	18.5%
76	Aortic Rupture	17.9%
77	Coronary heart disease	17.8%
78	Myocardial Infarction	17.8%
79	Acute Coronary Syndrome	17.8%
80	Myocardial Reperfusion Injury	17.7%
81	Intracranial Embolism and Thrombosis	17.2%
82	Intracranial Aneurysm	17.1%
83	Coronary Thrombosis	17.1%
84	Carotid Artery Thrombosis	16.5%
85	Hand-Arm Vibration Syndrome	16.1%
86	Optic Neuropathy, Ischemic	15.5%
87	Anterior Ischemic Optic Neuropathy	15.5%
88	Mesenteric vascular insufficiency	15.5%
89	Angioedema	15%
90	Colitis, Ischemic	14.9%
91	Air Embolism	14.8%
92	Endarteritis	14.8%
93	Polyarteritis Nodosa	14.8%
94	Takayasu Arteritis	14.8%
95	Venous Thrombosis	14.8%
96	Deep Vein Thrombosis	14.8%
97	Venous Thromboembolism	14.8%
98	Arteriovenous fistula	14%
99	Retinal Vasculitis	13.6%
100	Hypertensive Retinopathy	13.6%
101	Kounis Syndrome	13.6%
102	Vasculitis, Central Nervous System	13.4%
103	Anterior Compartment Syndrome	13.3%
104	Vasculitis, Leukocytoclastic, Cutaneous	13.3%
105	Gastric Antral Vascular Ectasia	13.3%
106	Abdominal Compartment Syndrome	13.3%
107	Cerebral Thrombosis	13.3%
108	Intracranial Embolism	13.3%
109	Intracranial Thrombosis	13.3%
110	May-Thurner Syndrome	13.2%
111	Carotid Artery Diseases	13.2%
112	Brain Ischemia	13.2%
113	Hypotension, Orthostatic	13.2%
114	Cerebrovascular accident	13.2%
115	Varicose Ulcer	13.2%
116	Vasospasm, Intracranial	13.2%
117	Spinal Cord Ischemia	13.2%
118	Intracranial Arterial Diseases	13.2%
119	Primary Graft Dysfunction	13.2%
120	Post-Exercise Hypotension	13.2%
121	Angina Pectoris	13.2%
122	Coronary Occlusion	13%
123	Microvascular Angina	13%
124	Coronary Stenosis	13%
125	ST segment elevation myocardial infarction	13%
126	Embolism, Amniotic Fluid	12.6%
127	Pregnancy Complications, Cardiovascular	12.2%
128	Cardiovascular Abnormalities	12.2%
129	Brain Infarction	11.6%
130	Sinus Thrombosis, Intracranial	11.4%
131	Giant Cell Arteritis	11%
132	Temporal Arteritis	11%
133	Coronary Restenosis	10.8%
134	Scimitar Syndrome	10.7%
135	Cavernous Sinus Thrombosis	10.5%
136	Sagittal Sinus Thrombosis	10.5%
137	Cardiac Tamponade	10.3%
138	Endocarditis	10.3%
139	Cardiac Arrest	10.3%
140	Heart failure	10.3%
141	Pericardial effusion	10.3%
142	Pericarditis	10.3%
143	Pneumopericardium	10.3%
144	Cor pulmonale	10.3%
145	Ventricular Outflow Obstruction	10.3%
146	Ventricular Dysfunction	10.3%
147	Cardiomyopathies	10.3%
148	Pleuropericarditis	10.3%
149	Lemierre Syndrome	10.2%
150	Mucocutaneous Lymph Node Syndrome	10.2%
151	Pulmonary Embolism	10.1%
152	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.1%
153	Dementia, Vascular	10.1%
154	Diabetic Retinopathy	10.1%
155	Sturge-Weber Syndrome	10.1%
156	Livedo Reticularis	10%
157	Renal hypertension	9.9%
158	No-Reflow Phenomenon	9.9%
159	Hemangioma, Cavernous	9.8%
160	Shock, Cardiogenic	9.8%
161	Basal Ganglia Cerebrovascular Disease	9.8%
162	Vertebral Artery Dissection	9.8%
163	Vascular Headaches	9.8%
164	Scurvy	9.8%
165	CREST Syndrome	9.7%
166	Cerebral Arterial Diseases	9.7%
167	Vertebrobasilar Insufficiency	9.7%
168	Anterior Spinal Artery Syndrome	9.7%
169	Basilar Artery Stenosis	9.7%
170	Vertebral Artery Stenosis	9.7%
171	Intracranial Hemorrhage, Hypertensive	9.7%
172	Transient Cerebral Ischemia	9.7%
173	Angina, Unstable	9.7%
174	Subarachnoid Hemorrhage, Traumatic	9.6%
175	Carotid Artery, Internal, Dissection	9.6%
176	Cerebral Infarction	9.6%
177	Brain Stem Infarctions	9.6%
178	Infarction, Middle Cerebral Artery	9.5%
179	Infarction, Anterior Cerebral Artery	9.5%
180	Infarction, Posterior Cerebral Artery	9.5%
181	Aortic Valve Stenosis	8.9%
182	Cardiomyopathy, Dilated	8.9%
183	Pulmonary Valve Stenosis	8.9%
184	Lateral Medullary Syndrome	8.6%
185	Hepatic Vein Thrombosis	8.4%
186	Budd-Chiari Syndrome	8.4%
187	Carotid Artery Injuries	8.4%
188	Pulmonary Infarction	8.2%
189	Subclavian Steal Syndrome	8%
190	Angina Pectoris, Variant	8%
191	Ischemic contracture	8%
192	Angioedemas, Hereditary	7.9%
193	Tricuspid Atresia	7.9%
194	Arrhythmogenic Right Ventricular Dysplasia	7.9%
195	Cryoglobulinemia	7.9%
196	Leukomalacia, Periventricular	7.9%
197	Diabetic Foot	7.8%
198	Basal Ganglia Hemorrhage	7.5%
199	Hypertension, Renovascular	7.3%
200	Subarachnoid Hemorrhage	7.3%
201	Hypoxia-Ischemia, Brain	7.3%
202	Cerebral Hemorrhage	7.3%
203	Hereditary Angioedema Type III	7.2%
204	Hereditary Angioedema Types I and II	7.2%
205	Hypertrophic Cardiomyopathy	7.1%
206	Hypertrophic obstructive cardiomyopathy	7.1%
207	Cardiac Output, High	7%
208	Myocardial Stunning	7%
209	Low Cardiac Output Syndrome	7%
210	Bacterial Endocarditis	6.8%
211	Cardiomegaly	6.8%
212	Postpericardiotomy Syndrome	6.8%
213	Cardiac Hypertrophy	6.8%
214	Rheumatic Heart Disease	6.7%
215	Aortic Valve Insufficiency	6.7%
216	Restrictive cardiomyopathy	6.7%
217	Endocardial Fibroelastosis	6.7%
218	Heart Block	6.7%
219	Heart Rupture, Post-Infarction	6.7%
220	Mitral Valve Insufficiency	6.7%
221	Mitral Valve Stenosis	6.7%
222	Myocarditis	6.7%
223	Pericarditis, Constrictive	6.7%
224	Pulmonary Valve Insufficiency	6.7%
225	Tachycardia	6.7%
226	Tricuspid Valve Insufficiency	6.7%
227	Tricuspid Valve Stenosis	6.7%
228	Tachyarrhythmia	6.7%
229	Ventricular Dysfunction, Left	6.7%
230	Right Ventricular Dysfunction	6.7%
231	Endomyocardial Fibrosis	6.7%
232	Carditis	6.7%
233	Heart Failure, Systolic	6.7%
234	Heart Failure, Diastolic	6.7%
235	Aortic coarctation	6.6%
236	Cor Triatriatum	6.6%
237	Coronary Vessel Anomalies	6.6%
238	Patent ductus arteriosus	6.6%
239	Ebstein Anomaly	6.6%
240	Heart Septal Defects	6.6%
241	Tetralogy of Fallot	6.6%
242	Transposition of Great Vessels	6.6%
243	Hypoplastic Left Heart Syndrome	6.6%
244	Shy-Drager Syndrome	6.5%
245	Supravalvular aortic stenosis	6.5%
246	Lown-Ganong-Levine Syndrome	6.5%
247	Purpura, Hyperglobulinemic	6.5%
248	Putaminal Hemorrhage	6.5%
249	Granulomatosis with polyangiitis	6.2%
250	Cerebral Amyloid Angiopathy	6%
251	Pituitary Apoplexy	5.9%
252	Behcet Syndrome	5.7%
253	Waldenstrom Macroglobulinemia	5.7%
254	Multiple Myeloma	5.7%
255	Dextrocardia	5.3%
256	Long QT Syndrome	5.3%
257	Ataxia Telangiectasia	5.1%
258	Pseudoxanthoma Elasticum	5%
259	Aortic Valve Prolapse	4.9%
260	Tricuspid Valve Prolapse	4.9%
261	Rheumatoid Vasculitis	4.9%
262	Takotsubo Cardiomyopathy	4.9%
263	Adams-Stokes Syndrome	4.9%
264	Atrioventricular Block	4.9%
265	Bundle-Branch Block	4.9%
266	Atrial Premature Complexes	4.9%
267	Sinoatrial Block	4.9%
268	Tachycardia, Paroxysmal	4.9%
269	Supraventricular tachycardia	4.9%
270	Tachycardia, Ventricular	4.9%
271	Wolff-Parkinson-White Syndrome	4.9%
272	Tachycardia, Reciprocating	4.9%
273	Lupus Vasculitis, Central Nervous System	4.9%
274	Sick Sinus Syndrome	4.9%
275	Aortopulmonary Septal Defect	4.9%
276	Double Outlet Right Ventricle	4.9%
277	Endocardial Cushion Defects	4.9%
278	Myocardial bridging	4.9%
279	Aorticopulmonary Septal Defect	4.9%
280	Sinus Arrhythmia	4.4%
281	Atrial Fibrillation	4.4%
282	Atrial Flutter	4.4%
283	Edema, Cardiac	4.4%
284	Ventricular Fibrillation	4.4%
285	Ventricular Flutter	4.4%
286	Parasystole	4.4%
287	Paroxysmal atrial fibrillation	4.4%
288	Bradycardia	4.4%
289	Diabetic Cardiomyopathies	4.4%
290	Cardiomyopathy, Alcoholic	4.4%
291	Ectopia Cordis	4.4%
292	Sudden Cardiac Death	4.4%
293	Left Ventricular Hypertrophy	4.4%
294	Right Ventricular Hypertrophy	4.4%
295	Single umbilical artery	4.4%
296	Chagas Cardiomyopathy	4.4%
297	Tachycardia, Atrioventricular Nodal Reentry	4%
298	Tachycardia, Ectopic Atrial	4%
299	Tachycardia, Ectopic Junctional	4%
300	Sinus Tachycardia	4%
301	Torsades de Pointes	4%
302	Accelerated Idioventricular Rhythm	4%
303	Truncus Arteriosus, Persistent	4%
304	Carcinoid Heart Disease	3.9%
305	Romano-Ward Syndrome	3.9%
306	Subacute Bacterial Endocarditis	3.8%
307	Noonan Syndrome	3.8%
308	Hematoma, Subdural	3.5%
309	Hematoma, Epidural, Cranial	3.5%
310	Marfan Syndrome	3.4%
311	Dyspnea, Paroxysmal	3.3%
312	Sinus Arrest, Cardiac	3.3%
313	Hematoma, Subdural, Intracranial	3.1%
314	Hematoma, Subdural, Chronic	3.1%
315	Hematoma, Subdural, Acute	3.1%
316	Brain Hemorrhage, Traumatic	3%
317	MELAS Syndrome	2.9%
318	Dural Arteriovenous Fistula	2.7%
319	Fabry Disease	2.2%
320	Turner Syndrome	1.8%
321	Williams Syndrome	1.6%
322	Kartagener Syndrome	1.5%
323	Kearns-Sayre syndrome	1.2%

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