MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aortic Rupture

(UMLS:C0003496)

Definition:: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.
UMLS ID:: C0003496
MeSH ID:: D001019

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.055.185.125|C14.907.055.239.175|C14.907.109.139.175

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.761.125

Synonym(s)

Aortic Rupture

Aortic rupture

aortic rupture

rupture aortic

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metoclopramide	FAERS: 6		US FAERS
2	Dabigatran	FAERS: 5		US FAERS
3	Rivaroxaban	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
4	rofecoxib	FAERS: 5		OFFSIDES US FAERS
5	liposomal amphotericin B	FAERS: 3		US FAERS
6	Clozapine	FAERS: 2		US FAERS
7	Daptomycin	FAERS: 2		US FAERS
8	Isotretinoin	FAERS: 2		US FAERS
9	Levofloxacin	FAERS: 2		US FAERS
10	Quetiapine Fumarate	FAERS: 2		US FAERS
11	Tacrolimus	FAERS: 2		US FAERS
12	Teriparatide	FAERS: 2		US FAERS
13	Bosentan	FAERS: 1		US FAERS
14	Cinacalcet	FAERS: 1		US FAERS
15	Dabigatran	FAERS: 1		US FAERS
16	Deferasirox	FAERS: 1		US FAERS
17	Diclofenac	FAERS: 1		US FAERS
18	Diovan Hct	FAERS: 1		US FAERS
19	Epinephrine	FAERS: 1		US FAERS
20	Eplerenone	FAERS: 1		US FAERS
21	Erlotinib Hydrochloride	FAERS: 1		US FAERS
22	Estrogens, Conjugated (USP)	FAERS: 1		US FAERS
23	Ibandronic Acid	FAERS: 1		US FAERS
24	Imatinib Mesylate	FAERS: 1		US FAERS
25	Levetiracetam	FAERS: 1		US FAERS
26	MDV 3100	FAERS: 1		US FAERS
27	Maraviroc	FAERS: 1		US FAERS
28	Mefloquine	FAERS: 1		US FAERS
29	Micafungin	FAERS: 1		US FAERS
30	Mycophenolic Acid	FAERS: 1		US FAERS
31	Octreotide	FAERS: 1		US FAERS
32	Paclitaxel	FAERS: 1		US FAERS
33	Rivastigmine	FAERS: 1		US FAERS
34	Rosiglitazone	FAERS: 1		US FAERS
35	Sildenafil Citrate	FAERS: 1		US FAERS
36	Solifenacin Succinate	FAERS: 1		US FAERS
37	Sunitinib	FAERS: 1		US FAERS
38	Ticlopidine	FAERS: 1		US FAERS
39	Tiotropium Bromide	FAERS: 1		US FAERS
40	Tobramycin	FAERS: 1		US FAERS
41	Zoledronic Acid	FAERS: 1		US FAERS
42	apixaban	FAERS: 1		US FAERS
43	betamethasone dipropionate, calcipotriol drug combination	FAERS: 1		US FAERS
44	eltrombopag	FAERS: 1		US FAERS
45	indacaterol	FAERS: 1		US FAERS
46	tofacitinib	FAERS: 1		US FAERS
47	treprostinil	FAERS: 1		US FAERS
48	valdecoxib	FAERS: 1		US FAERS
49	Alendronate			OFFSIDES
50	Ceftazidime			OFFSIDES
51	Cocaine		View details 1615817 3537786 18842920 20513064	CTD
52	Dioctyl Sulfosuccinic Acid			OFFSIDES
53	Doxycycline		18178469	CTD
54	Famotidine			OFFSIDES
55	Hydrocortisone			OFFSIDES
56	Medetomidine		16300184	CTD
57	Mepivacaine			OFFSIDES
58	Nifedipine			OFFSIDES
59	Norepinephrine			OFFSIDES
60	Prednisone		105598	CTD
61	Propranolol			OFFSIDES
62	Tigecycline			OFFSIDES
63	sibutramine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Aortic Aneurysm, Abdominal	50.3%
2	Aortic Aneurysm, Thoracic	50.3%
3	Aortitis	36.5%
4	Leriche Syndrome	36.5%
5	Coronary Aneurysm	35.2%
6	Myocardial Ischemia	33.9%
7	Aneurysm, Dissecting	33.8%
8	Iliac Aneurysm	33.8%
9	Vascular System Injuries	32.9%
10	Intracranial Aneurysm	32.3%
11	Angiomatosis	30.2%
12	Arterial Occlusive Diseases	30.2%
13	Hyperemia	30.2%
14	Hypotension	30.2%
15	Superior Vena Cava Syndrome	30.2%
16	Telangiectasis	30.2%
17	Vasculitis	30.2%
18	Venous Insufficiency	30.2%
19	Peripheral Vascular Diseases	30.2%
20	Embolism and Thrombosis	30.2%
21	Angiodysplasia	30.2%
22	Capillary Leak Syndrome	30.2%
23	Prehypertension	30.2%
24	Periphlebitis	29.8%
25	Phlebitis	29.8%
26	Thromboangiitis Obliterans	29.8%
27	Retinal Vein Occlusion	28.1%
28	Aortic Aneurysm	26.5%
29	Myocardial Reperfusion Injury	26.5%
30	Malignant Atrophic Papulosis	25.6%
31	Shwartzman Phenomenon	25.5%
32	Compartment syndromes	25.4%
33	Hepatic Veno-Occlusive Disease	25.4%
34	Peliosis Hepatis	25.4%
35	Varicocele	25.4%
36	Cerebrovascular Disorders	25.1%
37	Diabetic Angiopathies	25.1%
38	Reperfusion Injury	25.1%
39	Splenic Infarction	25.1%
40	Cerebrovascular Insufficiency	25.1%
41	Vascular Neoplasms	25.1%
42	Spinal Cord Vascular Diseases	25.1%
43	Vasoplegia	25.1%
44	Hemorrhoids	25%
45	Thoracic Outlet Syndrome	25%
46	Postphlebitic Syndrome	24.7%
47	Thrombophlebitis	23.1%
48	Hand-Arm Vibration Syndrome	22.2%
49	Optic Neuropathy, Ischemic	21.7%
50	Anterior Ischemic Optic Neuropathy	21.7%
51	Mesenteric vascular insufficiency	21.7%
52	Arteriovenous fistula	21.6%
53	Aortic Rupture	21.5%
54	Angioedema	21.3%
55	Colitis, Ischemic	21.3%
56	Moyamoya Disease	21.1%
57	Vertebral Artery Dissection	21.1%
58	Intracranial Embolism and Thrombosis	21.1%
59	Carotid Stenosis	21.1%
60	Blue Toe Syndrome	20.9%
61	Takayasu Arteritis	20.7%
62	Aortic Diseases	20.1%
63	Carotid Artery Thrombosis	20.1%
64	Vasculitis, Central Nervous System	20%
65	Coronary heart disease	19.9%
66	Myocardial Infarction	19.9%
67	Acute Coronary Syndrome	19.9%
68	Aneurysm, Ruptured	19.9%
69	Coronary Thrombosis	19.6%
70	Coronary Artery Disease	19.6%
71	Carotid Artery, Internal, Dissection	19.4%
72	Heart Diseases	18.6%
73	Scimitar Syndrome	18.2%
74	Arteriosclerosis	17.9%
75	Arteritis	17.9%
76	Embolism	17.9%
77	Erythromelalgia	17.9%
78	Fibromuscular Dysplasia	17.9%
79	Malignant Hypertension	17.9%
80	Raynaud Disease	17.9%
81	Thromboembolism	17.9%
82	Thrombosis	17.9%
83	Essential Hypertension	17.9%
84	Pulmonary artery stenosis	17.9%
85	White Coat Hypertension	17.9%
86	Systemic Vasculitis	17.9%
87	Embolus	17.9%
88	Kounis Syndrome	17.2%
89	May-Thurner Syndrome	17%
90	Angina Pectoris	16.9%
91	Polyarteritis Nodosa	16.9%
92	Intracranial Arteriosclerosis	16.8%
93	Cerebral Atherosclerosis	16.8%
94	Cerebral Arteriosclerosis	16.8%
95	Giant Cell Arteritis	16%
96	Temporal Arteritis	16%
97	Embolism, Amniotic Fluid	15.7%
98	Pregnancy Complications, Cardiovascular	15.6%
99	Cardiovascular Abnormalities	15.6%
100	Splenic Rupture	15.5%
101	Retinal Artery Occlusion	15.1%
102	Retinal Vasculitis	15.1%
103	Hypertensive Retinopathy	15.1%
104	Anterior Compartment Syndrome	14.9%
105	Vasculitis, Leukocytoclastic, Cutaneous	14.9%
106	Gastric Antral Vascular Ectasia	14.9%
107	Abdominal Compartment Syndrome	14.9%
108	Carotid Artery Diseases	14.8%
109	Brain Ischemia	14.8%
110	Hypotension, Orthostatic	14.8%
111	Cerebrovascular accident	14.8%
112	Varicose Ulcer	14.8%
113	Vasospasm, Intracranial	14.8%
114	Spinal Cord Ischemia	14.8%
115	Intracranial Arterial Diseases	14.8%
116	Primary Graft Dysfunction	14.8%
117	Post-Exercise Hypotension	14.8%
118	Subarachnoid Hemorrhage, Traumatic	14.7%
119	CREST Syndrome	14.7%
120	Cerebral Thrombosis	14.7%
121	Intracranial Embolism	14.7%
122	Intracranial Thrombosis	14.7%
123	Brain Infarction	14.6%
124	Carotid Artery Injuries	13.7%
125	Coronary Occlusion	13.1%
126	Microvascular Angina	13.1%
127	Coronary Stenosis	13.1%
128	ST segment elevation myocardial infarction	13.1%
129	Mesenteric Vascular Occlusion	12.9%
130	Mucocutaneous Lymph Node Syndrome	12.9%
131	Diabetic Retinopathy	12.9%
132	Sturge-Weber Syndrome	12.9%
133	Livedo Reticularis	12.8%
134	Renal hypertension	12.7%
135	Renal Artery Obstruction	12.7%
136	Renal Artery Stenosis	12.7%
137	Hemangioma, Cavernous	12.7%
138	Basal Ganglia Cerebrovascular Disease	12.7%
139	Vascular Headaches	12.6%
140	Scurvy	12.6%
141	Lemierre Syndrome	12.6%
142	Arteriosclerosis Obliterans	11.8%
143	Atherosclerosis	11.8%
144	Air Embolism	11.8%
145	Endarteritis	11.8%
146	Venous Thrombosis	11.8%
147	Deep Vein Thrombosis	11.8%
148	Venous Thromboembolism	11.8%
149	Frostbite	11.6%
150	Infarction, Middle Cerebral Artery	11.6%
151	Infarction, Anterior Cerebral Artery	11.6%
152	Infarction, Posterior Cerebral Artery	11.6%
153	Sinus Thrombosis, Intracranial	11.5%
154	Uterine Rupture	11.4%
155	Splenosis	11.3%
156	Shock, Cardiogenic	11.3%
157	Ischemic contracture	11.2%
158	Angina, Unstable	11.2%
159	Angioedemas, Hereditary	11.2%
160	Tricuspid Atresia	11.2%
161	Arrhythmogenic Right Ventricular Dysplasia	11.2%
162	Cryoglobulinemia	11.1%
163	Leukomalacia, Periventricular	11.1%
164	Diabetic Foot	11%
165	Cerebral Infarction	10.9%
166	Brain Stem Infarctions	10.9%
167	Basal Ganglia Hemorrhage	10.2%
168	Bacterial Endocarditis	10.1%
169	Aneurysm	10.1%
170	Cardiac Tamponade	10.1%
171	Endocarditis	10.1%
172	Cardiac Arrest	10.1%
173	Heart failure	10.1%
174	Pericardial effusion	10.1%
175	Pericarditis	10.1%
176	Pneumopericardium	10.1%
177	Cor pulmonale	10.1%
178	Ventricular Outflow Obstruction	10.1%
179	Ventricular Dysfunction	10.1%
180	Cardiomyopathies	10.1%
181	Pleuropericarditis	10.1%
182	Intermittent Claudication	10%
183	Pulmonary Embolism	10%
184	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10%
185	Aortic Valve Stenosis	9.9%
186	Cardiomyopathy, Dilated	9.9%
187	Pulmonary Valve Stenosis	9.9%
188	No-Reflow Phenomenon	9.9%
189	Cavernous Sinus Thrombosis	9.9%
190	Sagittal Sinus Thrombosis	9.9%
191	Uterine Perforation	9.9%
192	Shy-Drager Syndrome	9.8%
193	Purpura, Hyperglobulinemic	9.8%
194	Cerebral Arterial Diseases	9.8%
195	Vertebrobasilar Insufficiency	9.8%
196	Anterior Spinal Artery Syndrome	9.8%
197	Basilar Artery Stenosis	9.8%
198	Vertebral Artery Stenosis	9.8%
199	Intracranial Hemorrhage, Hypertensive	9.8%
200	Transient Cerebral Ischemia	9.8%
201	Coronary Restenosis	9.8%
202	Hip Fractures	9.6%
203	Lateral Medullary Syndrome	9.1%
204	Crush syndrome	9%
205	Femoral Fractures	9%
206	Tibial Fractures	9%
207	Behcet Syndrome	9%
208	Waldenstrom Macroglobulinemia	8.9%
209	Multiple Myeloma	8.9%
210	Heart Block	8.5%
211	Tachycardia	8.5%
212	Tachyarrhythmia	8.5%
213	Aortic coarctation	8.5%
214	Cor Triatriatum	8.5%
215	Coronary Vessel Anomalies	8.5%
216	Patent ductus arteriosus	8.5%
217	Ebstein Anomaly	8.5%
218	Heart Septal Defects	8.5%
219	Tetralogy of Fallot	8.5%
220	Transposition of Great Vessels	8.5%
221	Hypoplastic Left Heart Syndrome	8.5%
222	Cardiac Output, High	8.5%
223	Myocardial Stunning	8.5%
224	Low Cardiac Output Syndrome	8.5%
225	Hypertension, Renovascular	8.4%
226	Subarachnoid Hemorrhage	8.4%
227	Hypoxia-Ischemia, Brain	8.4%
228	Cerebral Hemorrhage	8.4%
229	Cardiomegaly	8.4%
230	Postpericardiotomy Syndrome	8.4%
231	Cardiac Hypertrophy	8.4%
232	Hereditary Angioedema Type III	8.4%
233	Hereditary Angioedema Types I and II	8.4%
234	Angina Pectoris, Variant	8.3%
235	Rheumatic Heart Disease	8.3%
236	Athletic Injuries	8.3%
237	Hand Injuries	8.3%
238	Soft Tissue Injuries	8.3%
239	Sprain	8.3%
240	Sprains and Strains	8.3%
241	Tendon Injuries	8.3%
242	Laceration	8.3%
243	Wounds, Penetrating	8.3%
244	Heat Cramps	8.3%
245	Ataxia Telangiectasia	8.2%
246	Pseudoxanthoma Elasticum	8.2%
247	Dementia, Vascular	8%
248	Putaminal Hemorrhage	7.9%
249	Chilblains	7.8%
250	Spinal Fractures	7.8%
251	Lupus Vasculitis, Central Nervous System	7.8%
252	Hip Dislocation	7.7%
253	Shoulder Dislocation	7.7%
254	Hip Dysplasia	7.7%
255	Hepatic Vein Thrombosis	7.5%
256	Budd-Chiari Syndrome	7.5%
257	Dextrocardia	7.4%
258	Long QT Syndrome	7.4%
259	Pituitary Apoplexy	7.4%
260	Hypertrophic Cardiomyopathy	7.4%
261	Pulmonary Infarction	7.4%
262	Hypertrophic obstructive cardiomyopathy	7.4%
263	Subclavian Steal Syndrome	7.3%
264	Trauma, Nervous System	7.1%
265	Bites and Stings	6.9%
266	Extravasation of Diagnostic and Therapeutic Materials	6.9%
267	Tympanic Membrane Perforation	6.9%
268	Tooth Injuries	6.9%
269	Brain Hemorrhage, Traumatic	6.9%
270	Asphyxia	6.9%
271	Esophageal Perforation	6.9%
272	Shock, Traumatic	6.9%
273	Self Mutilation	6.8%
274	Iliotibial Band Syndrome	6.6%
275	Rheumatoid Vasculitis	6.6%
276	Supravalvular aortic stenosis	6.6%
277	Lown-Ganong-Levine Syndrome	6.6%
278	Sick Sinus Syndrome	6.5%
279	Granulomatosis with polyangiitis	6.4%
280	Cerebral Amyloid Angiopathy	6.3%
281	Carcinoid Heart Disease	6.1%
282	Hematoma, Subdural	6%
283	Hematoma, Epidural, Cranial	6%
284	Noonan Syndrome	6%
285	Aortic Valve Insufficiency	6%
286	Restrictive cardiomyopathy	6%
287	Endocardial Fibroelastosis	6%
288	Heart Rupture, Post-Infarction	6%
289	Mitral Valve Insufficiency	6%
290	Mitral Valve Stenosis	6%
291	Myocarditis	6%
292	Pericarditis, Constrictive	6%
293	Pulmonary Valve Insufficiency	6%
294	Tricuspid Valve Insufficiency	6%
295	Tricuspid Valve Stenosis	6%
296	Ventricular Dysfunction, Left	6%
297	Right Ventricular Dysfunction	6%
298	Endomyocardial Fibrosis	6%
299	Carditis	6%
300	Heart Failure, Systolic	6%
301	Heart Failure, Diastolic	6%
302	Spinal Cord Injuries	5.9%
303	Eye Burns	5.9%
304	Drowning	5.9%
305	Adams-Stokes Syndrome	5.6%
306	Atrioventricular Block	5.6%
307	Bundle-Branch Block	5.6%
308	Atrial Premature Complexes	5.6%
309	Sinoatrial Block	5.6%
310	Tachycardia, Paroxysmal	5.6%
311	Supraventricular tachycardia	5.6%
312	Tachycardia, Ventricular	5.6%
313	Wolff-Parkinson-White Syndrome	5.6%
314	Tachycardia, Reciprocating	5.6%
315	Aortopulmonary Septal Defect	5.6%
316	Double Outlet Right Ventricle	5.6%
317	Endocardial Cushion Defects	5.6%
318	Myocardial bridging	5.6%
319	Aorticopulmonary Septal Defect	5.6%
320	Marfan Syndrome	5.5%
321	Subacute Bacterial Endocarditis	5.5%
322	Human Bite	5.4%
323	Contusions	5.4%
324	Decompression Sickness	5.4%
325	Finger Injuries	5.4%
326	Flail Chest	5.4%
327	Fractures, Closed	5.4%
328	Pathological fracture	5.4%
329	Heart Injuries	5.4%
330	Heat Exhaustion	5.4%
331	Heat Stroke	5.4%
332	Knee Injuries	5.4%
333	Foot Injuries	5.4%
334	Decapitation	5.4%
335	Ankle Fracture	5.4%
336	Avulsion fracture	5.4%
337	Compression fracture	5.4%
338	Osteoporotic Fractures	5.4%
339	Hematoma, Subdural, Intracranial	5.1%
340	Hematoma, Subdural, Chronic	5.1%
341	Hematoma, Subdural, Acute	5.1%
342	Radiation injury	5.1%
343	Brain Concussion	5%
344	Sinus Arrhythmia	5%
345	Atrial Fibrillation	5%
346	Atrial Flutter	5%
347	Edema, Cardiac	5%
348	Ventricular Fibrillation	5%
349	Ventricular Flutter	5%
350	Parasystole	5%
351	Paroxysmal atrial fibrillation	5%
352	Bradycardia	5%
353	Diabetic Cardiomyopathies	5%
354	Cardiomyopathy, Alcoholic	4.9%
355	Ectopia Cordis	4.9%
356	Sudden Cardiac Death	4.9%
357	Left Ventricular Hypertrophy	4.9%
358	Right Ventricular Hypertrophy	4.9%
359	Single umbilical artery	4.9%
360	Chagas Cardiomyopathy	4.9%
361	Romano-Ward Syndrome	4.9%
362	Craniocerebral Trauma	4.5%
363	Tendinitis	4.5%
364	Lung Injury	4.5%
365	Tendinopathy	4.5%
366	MELAS Syndrome	4.5%
367	Foreign-Body Reaction	4.5%
368	Insect Bites and Stings	4.5%
369	Paralysis, Obstetric	4.5%
370	Sunburn	4.5%
371	Tooth Avulsion	4.5%
372	Conus Medullaris Syndrome	4.5%
373	Near Drowning	4.4%
374	Osteoradionecrosis	4.4%
375	Brain Contusion	4.3%
376	Dyspnea, Paroxysmal	4.2%
377	Tachycardia, Atrioventricular Nodal Reentry	4.2%
378	Tachycardia, Ectopic Atrial	4.2%
379	Tachycardia, Ectopic Junctional	4.2%
380	Sinus Tachycardia	4.2%
381	Torsades de Pointes	4.2%
382	Accelerated Idioventricular Rhythm	4.2%
383	Truncus Arteriosus, Persistent	4.2%
384	Pseudarthrosis	4%
385	Smoke Inhalation Injury	4%
386	Aortic Valve Prolapse	3.9%
387	Tricuspid Valve Prolapse	3.9%
388	Takotsubo Cardiomyopathy	3.9%
389	Neoplasms, Radiation-Induced	3.9%
390	Peripheral Nerve Injuries	3.9%
391	Medial Tibial Stress Syndrome	3.9%
392	Central Cord Syndrome	3.8%
393	Dural Arteriovenous Fistula	3.7%
394	Fabry Disease	3.6%
395	Turner Syndrome	3.4%
396	Cardiotoxicity	3.4%
397	Leukemia, Radiation-Induced	3.4%
398	Radiation Pneumonitis	3.3%
399	Radiation Fibrosis	3.3%
400	Facial Injuries	3.3%
401	Granuloma, Foreign-Body	3.3%
402	Enthesopathy	3.3%
403	Sinus Arrest, Cardiac	3.3%
404	Abnormalities, Radiation-Induced	2.9%
405	Radiation Injuries, Experimental	2.9%
406	Brain Injuries	2.8%
407	Coma, Post-Head Injury	2.8%
408	Carpal Tunnel Syndrome	2.8%
409	Kartagener Syndrome	2.5%
410	Eye Injuries	2.4%
411	Brain Injuries, Diffuse	2.3%
412	Traumatic Brain Injury	2.3%
413	Cubital Tunnel Syndrome	2.3%
414	Diffuse Axonal Injury	2.1%
415	Kearns-Sayre syndrome	2.1%
416	Pneumocephalus	2.1%
417	Olfactory Nerve Injuries	2.1%
418	Cerebrospinal Fluid Otorrhea	2%
419	Cerebrospinal Fluid Rhinorrhea	2%
420	Epilepsy, Post-Traumatic	2%
421	Corneal Scar	1.9%
422	Williams Syndrome	1.8%
423	Facial Nerve Injuries	1.8%
424	Corneal Perforation	1.7%

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