MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypercalcemia

(UMLS:C0020437)

Definition:: Abnormally high level of calcium in the blood.
UMLS ID:: C0020437
MeSH ID:: D006934

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.174.451|C18.452.950.340

Synonym(s)

Hypercalcemia

Blood calcium increased

HYPERCALCAEMIA

HYPERCALCEMIA

High blood calcium levels

Hypercalcaemia

Hypercalcaemia syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1 alpha,24-dihydroxyvitamin D3	10927029 14684937 18173537	CTD
2	1,25-dihydroxy-16-ene-vitamin D3	7837819 7988477 14646396	CTD
3	24,25-Dihydroxyvitamin D 3	View details 2783309 3876564 6760236 11305809	CTD
4	25-hydroxyvitamin D	4018932	CTD
5	3,4-dihydroxyphenylglycol	7068199	CTD
6	Alendronate	12730757 17681097	CTD
7	Amiodarone	6409240	CTD
8	Aspirin	4004906	CTD
9	Bendroflumethiazide	17344567	CTD
10	Bortezomib	18089816	CTD
11	Calcitriol	View details 80633 1453499 1472092 1585935 1672178 1679904 1752077 2261743 2416438 2783309 3439654 3491995 3626302 3876564 6687780 6688127 6760236 7837819 7847357 7988477 8004848 8052367 8261678 8455354 8504051 8620449 8667442 9382671 9777124 10027919 10086871 10389917 10515239 10638776 10927029 11679963 11981061 12399635 12631365 14503802 17444814 17984431 18627265 18854204 19046703 19396601 20679997 21803404	CTD
12	Calcium Carbonate	View details 497950 625456 940186 1752077 2239937 2706898 3532984 3686151 4123179 4126071 5090792 7891547 8481062 8667442 8801073 11560570 15760782 16006300	CTD
13	Calcium Chloride	3144597 6540596 7520926	CTD
14	Calcium Citrate	16730623	CTD
15	Calcium Compounds	View details 3013062 3602993 7657155 8667442 19856155	CTD
16	Calcium Gluconate	7250652 14968361	CTD
17	Chloroquine	10638776	CTD
18	Chlorothiazide	2706898 5305802	CTD
19	Chlorthalidone	650822 4406789	CTD
20	Cinacalcet	View details 17060004 17315015 17472827 18721002 18775977	CTD
21	Clodronic Acid	10638776	CTD
22	Cocaine	16033719	CTD
23	Danazol	2616424 6697011	CTD
24	Diethylstilbestrol	4739237	CTD
25	Dihydrotachysterol	10515239	CTD
26	Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	19856155	CTD
27	Epinephrine	7068199	CTD
28	Ergocalciferols	View details 315115 3485083 4340673 5683703 8528347 9430241 16730623	CTD
29	Estramustine	9949296	CTD
30	Etidronic Acid	812508	CTD
31	Etretinate	6150159	CTD
32	Fluconazole	9767873	CTD
33	Foscarnet	9223751 9792397	CTD
34	Furosemide	451712 16006300 17652376	CTD
35	Ganciclovir	9894745	CTD
36	Hydrochlorothiazide	497950 5823744 20068444	CTD
37	Hydrocortisone	8667442	CTD
38	Indomethacin	View details 1152883 2248514 4032577 4835887	CTD
39	Isotretinoin	View details 6225882 7707116 8214363 18353067 18839433 19492317	CTD
40	Itraconazole	18584165	CTD
41	Lithium Carbonate	View details 59204 293541 595592 629344 8272143 11496029 14687875 17060004 18234408	CTD
42	Lithium	View details 1461037 2124533 3298507 3695842 7168087 7462168 9790163 10423626 10721295 10770468 11668758 16524864 16562448 17315015 17592473 19125999 19154241 19252941 20344995	CTD
43	Magnesium	3991404	CTD
44	Methylprednisolone	12653264	CTD
45	Metolazone	1928234	CTD
46	Normetanephrine	7068199	CTD
47	Octreotide	17625444	CTD
48	Omeprazole	10978407	CTD
49	Pamidronate	View details 1322674 2261743 8667442 10490077 11737750 12013365 12087588 12637657 16006300 17717370 19492317	CTD
50	Phosphates	5683348 8004848 9430241	CTD
51	Prednisolone	1115441	CTD
52	Prednisone	850496 4010837 9382671	CTD
53	Propranolol	3013062	CTD
54	Rennie	View details 6038342 10903467 12513010 18498570	CTD
55	Rifampin	3663501 9767873	CTD
56	Ro 23-7553	14646396 15364716	CTD
57	Sodium Bicarbonate	625456	CTD
58	Sodium Chloride	8483820	CTD
59	Sodium Citrate	15331942	CTD
60	Tamoxifen	View details 75435 89466 314575 519433 526949 534902 717984 870301 1457312 2102208 2327431 3870534 6255614 6937756 7259390 7260871 7357325 7362175 7457749 8241000 8540888 10465476 10593148 16622738 16837906	CTD
61	Terfenadine	15872215 19806302	CTD
62	Theophylline	3013062 17578191	CTD
63	Tretinoin	View details 1346313 7589349 7833269 8018908 8088385 8501972 11737750 16263588 18584165 18646608 20491286	CTD
64	Vitamin A	View details 1248399 3237276 4273771 4473880 4641958 4684742 6788164 7179960 7292640 11225264 15496578	CTD
65	Vitamin D	View details 232048 812508 1115441 1322674 2995910 3380067 4340673 4368776 6087399 6286738 6299054 6300812 6548177 7250652 7604500 7657155 8140079 8190198 8711172 9574950 10490077 11332696 14968361 17127264 19856155 20427501 21048240	CTD
66	Voriconazole	16263588	CTD
67	Zoledronic Acid	View details 15160319 18089816 18584165 19622757	CTD
68	alfacalcidol	View details 2616424 4004906 11675047 12960676 20453404	CTD
69	calcipotriene	View details 8011511 8120527 8490416 14999528 18173537	CTD
70	fosfluconazole	18646608	CTD
71	gallium nitrate	16622738 16837906	CTD
72	maxacalcitol	View details 8840326 10027919 14714959 18173537	CTD
73	mithramycin A	11261509	CTD
74	seocalcitol	9662243 14503802	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hypocalcemia	66.7%
2	Calcinosis	44.4%
3	Hyperkalemia	44.4%
4	Hypernatremia	44.4%
5	Hypokalemia	44.4%
6	Hyponatremia	44.4%
7	Wasting Syndrome	41.4%
8	Acid-Base Imbalance	40.9%
9	Iron Metabolism Disorders	40.9%
10	Phosphorus Metabolism Disorders	40.9%
11	Lipid Metabolism Disorders	40.9%
12	Mitochondrial Diseases	40.9%
13	Glucose Metabolism Disorders	40.9%
14	Pseudohypoparathyroidism	38.7%
15	Rickets	37.7%
16	Dehydration	33.9%
17	Water Intoxication	33.9%
18	Calciphylaxis	33%
19	Vascular calcification	33%
20	Lipodystrophy	32%
21	Osteopenia	31%
22	Brain Diseases, Metabolic	30.5%
23	Osteomalacia	28.3%
24	Leigh Disease	27%
25	Acidosis	26.7%
26	Alkalosis	26.7%
27	Amyloidosis	26.7%
28	Hyperglycemia	26.7%
29	Hyperinsulinism	26.7%
30	Hypoglycemia	26.7%
31	Xanthomatosis	26.7%
32	Hypophosphatemia	26.7%
33	Metabolic acidosis	26.7%
34	Dyslipidemias	26.7%
35	Iron Overload	26.7%
36	Xanthoma	26.7%
37	Brain Diseases, Metabolic, Inborn	26.5%
38	Hyperhomocysteinemia	25.3%
39	Carbamoyl-Phosphate Synthase I Deficiency Disease	24.7%
40	Hyperlipoproteinemia Type IV	24.3%
41	Hyperlipoproteinemia Type V	24.3%
42	Nutrition Disorders	23.8%
43	Familial Hypophosphatemic Rickets	23.7%
44	Hypolipoproteinemias	23.5%
45	Lactose Intolerance	23%
46	Smith-Lemli-Opitz Syndrome	22%
47	Galactosemias	21.9%
48	Urea Cycle Disorders, Inborn	21.9%
49	Tyrosinemias	21.9%
50	Diabetic Ketoacidosis	21.6%
51	Hyperlipidemia, Familial Combined	21.5%
52	Diabetes Mellitus	21.1%
53	Hyperlipoproteinemia Type III	20.5%
54	Calcium Metabolism Disorders	20.5%
55	Water-Electrolyte Imbalance	20.5%
56	Lipomatosis	20.3%
57	Werner Syndrome	20.3%
58	Congenital Hyperinsulinism	20.2%
59	Achlorhydria	20%
60	Amino Acid Metabolism, Inborn Errors	20%
61	Bloom Syndrome	20%
62	Carbohydrate Metabolism, Inborn Errors	20%
63	Hypercalcemia	20%
64	Metal Metabolism, Inborn Errors	20%
65	Milk-Alkali Syndrome	20%
66	Osteoporosis	20%
67	Progeria	20%
68	Lysosomal Storage Diseases	20%
69	Bone Demineralization, Pathologic	20%
70	Cytochrome-c Oxidase Deficiency	20%
71	Peroxisomal Disorders	20%
72	Post-Traumatic Osteoporosis	20%
73	Gaucher Disease	20%
74	Celiac Disease	19.8%
75	Sprue, Tropical	19.8%
76	Steatorrhea	19.8%
77	Sprue	19.8%
78	Acidosis, Lactic	19.8%
79	Hemosiderosis	19.8%
80	Ketosis	19.8%
81	Ketonuria	19.8%
82	Ketoacidosis	19.8%
83	Ketonemia	19.8%
84	Nephrocalcinosis	19.7%
85	Tetany	19.7%
86	Mitochondrial Encephalomyopathies	19.7%
87	Hyperphosphaturia	19.5%
88	Hypoalphalipoproteinemias	19.4%
89	Glycogen storage disease type II	19.2%
90	Renal Osteodystrophy	18.9%
91	Renal rickets	18.9%
92	Homocystinuria	18.5%
93	Tay-Sachs Disease	17.9%
94	Amyloid Neuropathies, Familial	17.4%
95	Niemann-Pick Disease, Type C	17%
96	Renal tubular acidosis	16.7%
97	Hypercholesterolemia	16.4%
98	Hyperlipoproteinemias	16.4%
99	Hypertriglyceridemia	16.4%
100	Nesidioblastosis	16.4%
101	Mitochondrial Myopathies	16.2%
102	Myelinolysis, Central Pontine	16.1%
103	Glycosuria	15.9%
104	Reye Syndrome	15.9%
105	Hepatic Encephalopathy	15.8%
106	Fabry Disease	15.7%
107	Neuronal Ceroid-Lipofuscinoses	15.4%
108	Adrenoleukodystrophy	15.1%
109	HIV Wasting Syndrome	15.1%
110	MELAS Syndrome	15%
111	Acidosis, Respiratory	14.9%
112	Adiposis Dolorosa	14.9%
113	Alkalosis, Respiratory	14.9%
114	Zellweger Syndrome	14.8%
115	Alkaptonuria	14.8%
116	Glycogen Storage Disease	14.8%
117	Hypophosphatasia	14.8%
118	Insulin Resistance	14.8%
119	Osteoporosis, Postmenopausal	14.8%
120	Propionic acidemia	14.8%
121	Dihydropyrimidine Dehydrogenase Deficiency	14.8%
122	Cystinosis	14.8%
123	HIV-Associated Lipodystrophy Syndrome	14.7%
124	Menkes Kinky Hair Syndrome	14.6%
125	Mucopolysaccharidosis III	13.8%
126	Hepatolenticular Degeneration	13.7%
127	Child Nutrition Disorders	13.6%
128	Hypervitaminosis A	13.6%
129	Infant Nutrition Disorders	13.6%
130	Malnutrition	13.6%
131	Porphyrias, Hepatic	13.5%
132	Refsum Disease	13.5%
133	Wernicke Encephalopathy	13.3%
134	Necrobiosis Lipoidica Diabeticorum	13.3%
135	Fanconi Anemia	13.1%
136	Glycosuria, Renal	12.9%
137	Gestational Diabetes	12.2%
138	Latent Autoimmune Diabetes in Adults	12.2%
139	CREST Syndrome	12.2%
140	Glycogen Storage Disease Type I	12.2%
141	Glycogen Storage Disease Type V	12.2%
142	Diabetes Mellitus, Experimental	12.1%
143	Cerebral Amyloid Angiopathy	11.7%
144	Friedreich Ataxia	11.2%
145	Kearns-Sayre syndrome	10.5%
146	Kernicterus	10%
147	Familial Periodic Paralysis	10%
148	Cockayne Syndrome	10%
149	Primary amyloidosis	9.9%
150	Variegate Porphyria	9.8%
151	Acute intermittent porphyria	9.8%
152	Porphyria Cutanea Tarda	9.8%
153	Sjogren-Larsson Syndrome	9.8%
154	Renal Aminoacidurias	9.8%
155	Fanconi Syndrome	9.8%
156	Pseudohypoaldosteronism	9.8%
157	Liddle Syndrome	9.8%
158	Canavan Disease	9.7%
159	Alexander Disease	9.7%
160	Mucopolysaccharidosis II	9.7%
161	Ataxia Telangiectasia	9%
162	Deficiency Diseases	8.9%
163	Starvation	8.9%
164	Refeeding Syndrome	8.9%
165	Optic Atrophy, Hereditary, Leber	8.7%
166	Gout	8.6%
167	Amyotrophic Lateral Sclerosis	8.5%
168	Antley-Bixler Syndrome Phenotype	8.4%
169	Hypokalemic periodic paralysis	8.2%
170	Frontotemporal dementia	8.1%
171	Cystinuria	8.1%
172	Xeroderma Pigmentosum	8.1%
173	Arthritis, Gouty	7%
174	Albinism	6.6%
175	Kwashiorkor	6.6%
176	Magnesium Deficiency	6.6%
177	Potassium Deficiency	6.6%
178	Protein Deficiency	6.6%
179	Avitaminosis	6.6%
180	Ascorbic Acid Deficiency	5.5%
181	Vitamin A Deficiency	5.5%
182	Vitamin D Deficiency	5.5%
183	Vitamin E Deficiency	5.5%
184	Marasmus	5.5%
185	Ichthyosis, X-Linked	5.4%
186	Folic Acid Deficiency	4.9%
187	Pellagra	4.9%
188	Thiamine Deficiency	4.9%
189	Vitamin B 12 Deficiency	4.9%
190	Vitamin B 6 Deficiency	4.9%
191	Pyridoxine Deficiency	4.9%
192	Beriberi	4.6%
193	Obesity	4.3%
194	Obesity, Abdominal	3.9%
195	Anemia, Pernicious	3.4%
196	Vitamin K Deficiency	3.3%
197	Pediatric Obesity	3.2%
198	Scurvy	2.9%
199	Prader-Willi Syndrome	2.8%
200	Subacute Combined Degeneration	2%

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