MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Enthesopathy

(UMLS:C0242490)

Definition:: A disorder occurring at the site of insertion of TENDONS or LIGAMENTS into bones or JOINT CAPSULES.
UMLS ID:: C0242490
MeSH ID:: D000070676

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.869.653

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.874.800.750

Synonym(s)

Enthesopathy

Enthesopathy of unspecified site

Enthesopathy of unspecified site, NOS

Enthesopathy, unspecified

enthesopathies

enthesopathy

ligament; disorder ligamentous attachments

muscular; disease, attachments

unspecified enthesopathy

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 24	US FAERS
2	Levofloxacin	FAERS: 4	US FAERS
3	Ciprofloxacin	FAERS: 3	US FAERS
4	Isotretinoin	FAERS: 3	US FAERS
5	rofecoxib	FAERS: 3	US FAERS
6	tofacitinib	FAERS: 3	US FAERS
7	Prednisone	FAERS: 2	US FAERS
8	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
9	Ciprofloxacin	FAERS: 1	US FAERS
10	Cyclosporine	FAERS: 1	US FAERS
11	Duloxetine Hydrochloride	FAERS: 1	US FAERS
12	Fingolimod Hydrochloride	FAERS: 1	US FAERS
13	Ibandronic Acid	FAERS: 1	US FAERS
14	Mirtazapine	FAERS: 1	US FAERS
15	Moxifloxacin	FAERS: 1	US FAERS
16	Norgestrel	FAERS: 1	US FAERS
17	Orlistat	FAERS: 1	US FAERS
18	Thyroxine	FAERS: 1	US FAERS
19	Vemurafenib	FAERS: 1	US FAERS
20	Zoledronic Acid	FAERS: 1 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
21	apremilast	FAERS: 1	US FAERS
22	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
23	Acitretin		OFFSIDES
24	Amiloride		OFFSIDES
25	Anastrozole		OFFSIDES
26	Beclomethasone		OFFSIDES
27	Beclomethasone		OFFSIDES
28	Chlorhexidine		OFFSIDES
29	Diphenoxylate		OFFSIDES
30	Doxylamine		OFFSIDES
31	Letrozole		OFFSIDES
32	Methotrexate	Canada Vigilance: 1	Canada Vigilance
33	Naproxen		OFFSIDES
34	Nevirapine		OFFSIDES
35	Norfloxacin		OFFSIDES
36	Octreotide		OFFSIDES
37	Pentamidine		OFFSIDES
38	Pyridoxine		OFFSIDES
39	Quinidine		OFFSIDES
40	Sumatriptan		OFFSIDES
41	Tamoxifen		OFFSIDES
42	Tenofovir		OFFSIDES
43	Tobramycin		OFFSIDES
44	Tretinoin		OFFSIDES
45	Ubiquinone		OFFSIDES
46	Vinorelbine		OFFSIDES
47	brinzolamide		OFFSIDES
48	cefuroxime axetil		OFFSIDES
49	chlorhexidine gluconate		OFFSIDES
50	exemestane		OFFSIDES
51	samarium Sm-153 lexidronam		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Tenosynovitis	31.1%
2	Contracture	20.7%
3	Myofascial Pain Syndromes	20.5%
4	Rhabdomyolysis	20.5%
5	Arthrogryposis	17.2%
6	Fibromyalgia	16.4%
7	Polymyalgia Rheumatica	16.4%
8	Medial Tibial Stress Syndrome	16.4%
9	Ischemic contracture	15.6%
10	Compartment syndromes	15.5%
11	Myositis	15.3%
12	Isaacs syndrome	15.3%
13	Myotonic Disorders	15.3%
14	Frostbite	14.3%
15	Fibrodysplasia Ossificans Progressiva	13.3%
16	Hip Contracture	13.3%
17	Myoglobinuria	13.3%
18	Myositis Ossificans	13.3%
19	Mitochondrial Myopathies	12.2%
20	Muscle Cramp	12.1%
21	Eosinophilia-Myalgia Syndrome	12.1%
22	Muscle Rigidity	12%
23	Muscle Spasticity	12%
24	Cogwheel Rigidity	12%
25	Nuchal Rigidity	12%
26	Athletic Injuries	11.9%
27	Bone Diseases	11.9%
28	Fasciitis	11.9%
29	Foot Deformities	11.9%
30	Hand Injuries	11.9%
31	Arthropathy	11.9%
32	Soft Tissue Injuries	11.9%
33	Sprain	11.9%
34	Sprains and Strains	11.9%
35	Laceration	11.9%
36	Wounds, Penetrating	11.9%
37	Heat Cramps	11.9%
38	Rupture	11.9%
39	Temporomandibular Joint Dysfunction Syndrome	11.4%
40	Hip Dislocation	11%
41	Shoulder Dislocation	11%
42	Hip Dysplasia	11%
43	Chronic Fatigue Syndrome	10.6%
44	Crush syndrome	10.3%
45	Femoral Fractures	10.3%
46	Osteoarthropathy, Secondary Hypertrophic	10.3%
47	Tibial Fractures	10.3%
48	Fasciitis, Plantar	10.3%
49	Temporomandibular Joint Disorders	10.3%
50	Muscle Weakness	10.2%
51	Musculoskeletal Pain	10.1%
52	Anterior Compartment Syndrome	10%
53	Familial Periodic Paralysis	10%
54	Abdominal Compartment Syndrome	10%
55	Polymyositis	9.9%
56	Hip Fractures	9.5%
57	Jaw Diseases	9.3%
58	Trauma, Nervous System	9.3%
59	Bites and Stings	8.9%
60	Cartilage Diseases	8.9%
61	Extravasation of Diagnostic and Therapeutic Materials	8.9%
62	Foot Diseases	8.9%
63	Rheumatism	8.9%
64	Chondromalacia	8.9%
65	Vascular System Injuries	8.9%
66	Tympanic Membrane Perforation	8.9%
67	Tooth Injuries	8.9%
68	Asphyxia	8.8%
69	Esophageal Perforation	8.8%
70	Shock, Traumatic	8.8%
71	Self Mutilation	8.7%
72	Myalgia	8.5%
73	Chilblains	8.5%
74	Spinal Fractures	8.5%
75	Osteochondritis	8.2%
76	Splenic Rupture	8.2%
77	Metatarsalgia	8.2%
78	Muscular Dystrophy	8.1%
79	Orbital Myositis	8.1%
80	Dupuytren Contracture	8%
81	Pyomyositis	7.9%
82	Pectus carinatum	7.8%
83	Myotonic Dystrophy	7.7%
84	Spinal Cord Injuries	7%
85	Drowning	6.9%
86	Arthritis	6.8%
87	Human Bite	6.8%
88	Bone Diseases, Developmental	6.8%
89	Bursitis	6.8%
90	Contusions	6.8%
91	Decompression Sickness	6.8%
92	Finger Injuries	6.8%
93	Flail Chest	6.8%
94	Fractures, Closed	6.8%
95	Pathological fracture	6.8%
96	Heart Injuries	6.8%
97	Heat Exhaustion	6.8%
98	Heat Stroke	6.8%
99	Hyperostosis	6.8%
100	Joint Instability	6.8%
101	Knee Injuries	6.8%
102	Osteitis	6.8%
103	Osteitis Deformans	6.8%
104	Osteochondrosis	6.8%
105	Spinal Diseases	6.8%
106	Synovitis	6.8%
107	Joint laxity	6.8%
108	Foot Injuries	6.8%
109	Decapitation	6.8%
110	Ankle Fracture	6.8%
111	Polyarthritis	6.8%
112	Frozen shoulder	6.8%
113	Avulsion fracture	6.8%
114	Compression fracture	6.8%
115	Osteoporotic Fractures	6.8%
116	Patellofemoral Pain Syndrome	6.8%
117	Osteoarthritis, Spine	6.8%
118	Pectus excavatum	6.8%
119	Rheumatic Fever	6.7%
120	Gout	6.7%
121	Periarthritis	6.7%
122	Iliotibial Band Syndrome	6.7%
123	Myotonia Congenita	6.6%
124	Platybasia	6.6%
125	Hypokalemic periodic paralysis	6.5%
126	Klippel-Feil Syndrome	6%
127	Synostosis	6%
128	Welander Distal Myopathy	5.9%
129	Osteoarthritis, Knee	5.8%
130	Talipes	5.7%
131	Ankylosing spondylitis	5.7%
132	Rheumatoid Arthritis	5.7%
133	Juvenile arthritis	5.7%
134	Radiation injury	5.7%
135	Mitochondrial Encephalomyopathies	5.6%
136	Eye Burns	5.6%
137	Bone Diseases, Endocrine	5.4%
138	Gigantism	5.3%
139	Spinal Neoplasms	5.3%
140	Spondylitis	5.3%
141	Splenosis	5.3%
142	Bone Diseases, Infectious	5.2%
143	Bone neoplasms	5.2%
144	Craniocerebral Trauma	5.2%
145	Maxillary Diseases	5.2%
146	Osteopenia	5.2%
147	Lung Injury	5.2%
148	Bone Resorption	5.1%
149	Foreign-Body Reaction	5.1%
150	Hemarthrosis	5.1%
151	Insect Bites and Stings	5.1%
152	Paralysis, Obstetric	5.1%
153	Sunburn	5.1%
154	Tietze's Syndrome	5.1%
155	Tooth Avulsion	5.1%
156	Limb Deformities, Congenital	5.1%
157	Craniofacial Abnormalities	5.1%
158	Aseptic Necrosis of Bone	5.1%
159	Conus Medullaris Syndrome	5.1%
160	Dermatomyositis	5%
161	Near Drowning	5%
162	Osteoradionecrosis	5%
163	Muscular Dystrophy, Duchenne	4.9%
164	Craniosynostosis	4.9%
165	Syndactyly	4.9%
166	Brachycephaly	4.9%
167	Arthritis, Psoriatic	4.7%
168	Arthritis, Gouty	4.7%
169	Craniofacial Dysostosis	4.6%
170	Rheumatoid Nodule	4.6%
171	Spondylarthropathies	4.5%
172	Ainhum	4.4%
173	Bunion	4.4%
174	Congenital clubfoot	4.4%
175	Dysostoses	4.4%
176	Pseudarthrosis	4.4%
177	Smoke Inhalation Injury	4.4%
178	Spinal Stenosis	4.4%
179	Spondylosis	4.4%
180	Intervertebral Disc Degeneration	4.4%
181	Vertical Talus	4.4%
182	Sacroiliitis	4.4%
183	Acrocephalosyndactylia	4.4%
184	Arthritis, Reactive	4.2%
185	Neoplasms, Radiation-Induced	4.2%
186	Peripheral Nerve Injuries	4.1%
187	Uterine Rupture	4%
188	Gastroschisis	4%
189	Central Cord Syndrome	4%
190	Discitis	3.9%
191	Brain Concussion	3.9%
192	Felty Syndrome	3.8%
193	Poland Syndrome	3.8%
194	Jaw Abnormalities	3.8%
195	Brain Contusion	3.5%
196	Prognathism	3.4%
197	Cardiotoxicity	3.4%
198	Nail-Patella Syndrome	3.4%
199	Arthritis, Infectious	3.4%
200	Giant Cell Epulis	3.4%
201	Leukemia, Radiation-Induced	3.4%
202	Multiple Epiphyseal Dysplasia	3.4%
203	Osteochondrodysplasias	3.4%
204	Radiation Pneumonitis	3.4%
205	Radiation Fibrosis	3.4%
206	Congenital Hypothyroidism	3.3%
207	Facial Injuries	3.3%
208	Granuloma, Foreign-Body	3.3%
209	Osteomyelitis	3.3%
210	Osteoporosis	3.3%
211	Periostitis	3.3%
212	Bone Demineralization, Pathologic	3.3%
213	Post-Traumatic Osteoporosis	3.3%
214	Arthritis, Experimental	3.3%
215	Aortic Rupture	3.3%
216	Arthralgia	3.3%
217	Polyarthralgia	3.3%
218	Alveolar Bone Loss	3.3%
219	Amelia	3.3%
220	Arachnodactyly	3.3%
221	Ectromelia	3.3%
222	Femur Head Necrosis	3.3%
223	Hemimelia	3.3%
224	Phocomelia	3.3%
225	Sirenomelia	3.3%
226	Polydactyly	3.3%
227	Brachydactyly	3.3%
228	Plagiocephaly	3.3%
229	Lower Extremity Deformities, Congenital	3.3%
230	Upper Extremity Deformities, Congenital	3.3%
231	Osteolysis	3.3%
232	Chondrodysplasia Punctata	3.3%
233	Enchondromatosis	3.3%
234	Lordosis	3.3%
235	Osteosclerosis	3.3%
236	Spondylolysis	3.3%
237	kyphosis	3.3%
238	Kashin-Beck Disease	3.3%
239	Uterine Perforation	3.3%
240	Rheumatoid Vasculitis	3.3%
241	Tuberculosis, Spinal	3.2%
242	Goldenhar Syndrome	3.1%
243	Antley-Bixler Syndrome Phenotype	3%
244	Mandibulofacial Dysostosis	3%
245	Laryngomalacia	2.9%
246	Sicca Syndrome	2.9%
247	Sjogren's Syndrome	2.9%
248	Abnormalities, Radiation-Induced	2.9%
249	Eosinophilic Granuloma	2.8%
250	Radiation Injuries, Experimental	2.8%
251	Dwarfism	2.8%
252	Melorheostosis	2.7%
253	Osteopetrosis	2.7%
254	Spondylolisthesis	2.7%
255	Brain Injuries	2.7%
256	Palatal Neoplasms	2.7%
257	Micrognathism	2.6%
258	Pierre Robin Syndrome	2.6%
259	MELAS Syndrome	2.6%
260	Acromegaly	2.6%
261	Joint Tuberculosis	2.6%
262	Tuberculosis, Osteoarticular	2.6%
263	Coma, Post-Head Injury	2.6%
264	Bone Tuberculosis	2.6%
265	Carpal Tunnel Syndrome	2.6%
266	Rubinstein-Taybi Syndrome	2.6%
267	Osteoporosis, Postmenopausal	2.5%
268	Kearns-Sayre syndrome	2.4%
269	Retrognathia	2.4%
270	Maxillofacial Abnormalities	2.2%
271	Rickets	2.2%
272	Bronchomalacia	2.2%
273	Tracheomalacia	2.2%
274	Microcephaly	2.2%
275	Macrocephaly	2.2%
276	Shoulder Pain	2.2%
277	Brain Hemorrhage, Traumatic	2.2%
278	Basal Cell Nevus Syndrome	2.1%
279	Eye Injuries	2.1%
280	Osteogenesis Imperfecta	2%
281	Mastoiditis	2%
282	Petrositis	2%
283	Brain Injuries, Diffuse	2%
284	Traumatic Brain Injury	2%
285	Cubital Tunnel Syndrome	1.9%
286	Cleft Palate	1.9%
287	Pseudohypoparathyroidism	1.9%
288	Vertebral Artery Dissection	1.9%
289	Noonan Syndrome	1.7%
290	Pneumocephalus	1.7%
291	Olfactory Nerve Injuries	1.6%
292	Cerebrospinal Fluid Otorrhea	1.6%
293	Cerebrospinal Fluid Rhinorrhea	1.6%
294	Carotid Artery Injuries	1.6%
295	Epilepsy, Post-Traumatic	1.6%
296	Osteomalacia	1.6%
297	Porencephaly	1.6%
298	Diffuse Axonal Injury	1.6%
299	Marfan Syndrome	1.5%
300	Holoprosencephaly	1.5%
301	Facial Nerve Injuries	1.4%
302	Corneal Scar	1.4%
303	Cockayne Syndrome	1.2%
304	Corneal Perforation	1.2%
305	Hematoma, Subdural	1.2%
306	Hematoma, Epidural, Cranial	1.2%
307	Radicular Cyst	1.2%
308	Nose Neoplasms	1.1%
309	Renal Osteodystrophy	1.1%
310	Renal rickets	1.1%
311	Subarachnoid Hemorrhage, Traumatic	1.1%
312	Carotid Artery, Internal, Dissection	1.1%
313	Hematoma, Subdural, Intracranial	1%
314	Hematoma, Subdural, Chronic	1%
315	Hematoma, Subdural, Acute	1%
316	Familial Hypophosphatemic Rickets	0.6%

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