MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Limb Deformities, Congenital

(UMLS:C0206762)

Definition:: Congenital structural deformities of the upper and lower extremities collectively or unspecified.
UMLS ID:: C0206762
MeSH ID:: D017880

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.585

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585

Synonym(s)

Limb Deformities, Congenital

CONGENITAL ABNORMALITY OF LIMB

Congenital abnormality of the limb

Congenital anomaly of limb

Congenital anomaly of limb, NOS

Congenital deformity of limb

Congenital deformity of limb, NOS

LIMB ANOMALY CONGENITAL

LIMB MALFORMATION

10.

Limb malformation

11.

Unspecified anomaly of unspecified limb

12.

Unspecified congenital malformation of limb(s)

13.

congenital deformity of limb

14.

limb malformation

15.

limb malformations

16.

limbs malformation

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2-(2,6-dioxopiperidin-3-yl)phthalimidine	3355362 6734493	CTD
2	2-amino-1,3,4-thiadiazole	4269736	CTD
3	3,3',5-triiodothyroacetic acid	29458080	CTD
4	Acitretin	8838291	CTD
5	Alcohols	17676605	CTD
6	Allopurinol	12115777	CTD
7	Aminopterin	10413333	CTD
8	Astemizole	20144703	CTD
9	BMS 189453	17676605	CTD
10	BMS 961	18703560	CTD
11	Carbamazepine	2492459 15644835	CTD
12	Cocaine	1326132	CTD
13	Cyclophosphamide	10482872	CTD
14	Dichlorodiphenyl Dichloroethylene	12745335	CTD
15	Diethylstilbestrol	14659782	CTD
16	Disulfiram	17676605	CTD
17	Endosulfan	21036383	CTD
18	Fluorouracil	9299594	CTD
19	Hydroxyurea	23696560	CTD
20	Leflunomide	19751817	CTD
21	Maloprim	2859662	CTD
22	Mercaptopurine	22688000	CTD
23	Methotrexate	10413333	CTD
24	Methylnitrosourea	11091363 15526292	CTD
25	Misoprostol	18516817	CTD
26	Niacinamide	4269736	CTD
27	Oxamic Acid	29458080	CTD
28	Phenobarbital	2492459 15644835	CTD
29	Phenytoin	2492459 7294529 15644835	CTD
30	Polychlorinated Dibenzodioxins	30398377	CTD
31	Primidone	2492459	CTD
32	Pyran Copolymer	11091363	CTD
33	Thalidomide	View details 4631040 10473037 19751816 21505091	CTD
34	Tretinoin	View details 2718176 6648825 9224671 9535508 18703560 20117194 22498432	CTD
35	Triiodothyronine	29458080	CTD
36	Urethane	11091363	CTD
37	Valproic Acid	View details 2284927 2492459 15794725 20025093	CTD
38	Vitamin A	16054864	CTD
39	azadirachtin	17517339	CTD
40	benz(a)anthracene	29630969	CTD
41	methoxyacetic acid	12805644 15959878	CTD
42	methyl cellosolve	6499821	CTD
43	pyrene	29630969	CTD
44	retene	29630969	CTD
45	tetraiodothyroacetic acid	29458080	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Craniofacial Abnormalities	44.8%
2	Pectus excavatum	39.7%
3	Arthrogryposis	39.5%
4	Craniosynostosis	39%
5	Brachycephaly	39%
6	Klippel-Feil Syndrome	38.8%
7	Synostosis	38.8%
8	Gastroschisis	35.4%
9	Plagiocephaly	32.8%
10	Pectus carinatum	32.4%
11	Craniofacial Dysostosis	29.3%
12	Maxillofacial Abnormalities	28.8%
13	Acrocephalosyndactylia	28.5%
14	Platybasia	28.5%
15	Holoprosencephaly	28.1%
16	Rubinstein-Taybi Syndrome	26.6%
17	Microcephaly	25.6%
18	Macrocephaly	25.6%
19	Goldenhar Syndrome	21.9%
20	Antley-Bixler Syndrome Phenotype	21.9%
21	Porencephaly	21.9%
22	Abnormalities, Drug-Induced	20.9%
23	Situs Inversus	20.9%
24	Jaw Abnormalities	20.8%
25	Syndactyly	20.6%
26	Mandibulofacial Dysostosis	20.3%
27	Noonan Syndrome	20.2%
28	Beckwith-Wiedemann Syndrome	18.9%
29	Wolf-Hirschhorn Syndrome	18.9%
30	Laryngomalacia	17.8%
31	Micrognathism	17.5%
32	Pierre Robin Syndrome	17.5%
33	Poland Syndrome	17.1%
34	Eye Abnormalities	16.4%
35	Cardiovascular Abnormalities	16.4%
36	Prognathism	16%
37	Smith-Magenis syndrome	15.9%
38	Skin Abnormalities	15.8%
39	Lymphatic Abnormalities	15.8%
40	Congenital Microtia	15.8%
41	Cri-du-Chat Syndrome	15.6%
42	Down Syndrome	15.6%
43	Trisomy 21	15.6%
44	Retrognathia	15.6%
45	Cleft Palate	15.5%
46	Congenital diaphragmatic hernia	15.4%
47	Bronchomalacia	15%
48	Tracheomalacia	15%
49	Nail-Patella Syndrome	14.9%
50	Aicardi's syndrome	14.9%
51	Bone Diseases	14.6%
52	Fasciitis	14.6%
53	Foot Deformities	14.6%
54	Arthropathy	14.6%
55	Anencephaly	14.1%
56	Contracture	14%
57	Osteoarthropathy, Secondary Hypertrophic	14%
58	Fasciitis, Plantar	14%
59	Prune Belly Syndrome	13.6%
60	Twins, Conjoined	13.6%
61	Waardenburg Syndrome	13.6%
62	Ectodermal Dysplasia	13.5%
63	Aplasia Cutis Congenita	13.5%
64	Prader-Willi Syndrome	13.3%
65	Urogenital Abnormalities	13%
66	Marfan Syndrome	12.5%
67	CHARGE Syndrome	12.3%
68	Genetic Diseases, Inborn	12.2%
69	Dural Arteriovenous Fistula	11.9%
70	Dextrocardia	11.7%
71	Jaw Diseases	11.3%
72	Osteoarthritis, Spine	11.3%
73	Fibromyalgia	11.1%
74	Osteochondritis	11.1%
75	Polymyalgia Rheumatica	11.1%
76	Gout	11.1%
77	Metatarsalgia	11%
78	Cartilage Diseases	10.9%
79	Foot Diseases	10.9%
80	Myopathy	10.9%
81	Rheumatism	10.9%
82	Chondromalacia	10.9%
83	Kartagener Syndrome	10.8%
84	Cockayne Syndrome	10.5%
85	Anophthalmos	10.3%
86	Anus, Imperforate	10.3%
87	Hydranencephaly	10.3%
88	Microphthalmos	10.3%
89	Multiple Epiphyseal Dysplasia	10.3%
90	Neural Tube Defects	10.3%
91	Osteochondrodysplasias	10.3%
92	Tethered Cord Syndrome	10.3%
93	Iniencephaly	10.3%
94	Craniorachischisis	10.3%
95	Exencephaly	10.3%
96	Septo-Optic Dysplasia	10.3%
97	Cortical Dysplasia	10.3%
98	Malformations of Cortical Development	10.3%
99	Anorectal Malformations	10.3%
100	Xeroderma	10.2%
101	Mobius Syndrome	10.2%
102	Bloom Syndrome	10.2%
103	Hip Contracture	10.2%
104	Periarthritis	10.2%
105	Ischemic contracture	10.1%
106	Ankylosing spondylitis	9.8%
107	Rheumatic Fever	9.5%
108	Temporomandibular Joint Disorders	9.4%
109	Arthritis	9.3%
110	Bone Diseases, Developmental	9.3%
111	Bursitis	9.3%
112	Hyperostosis	9.3%
113	Joint Instability	9.3%
114	Myofascial Pain Syndromes	9.3%
115	Osteitis	9.3%
116	Osteitis Deformans	9.3%
117	Osteochondrosis	9.3%
118	Rhabdomyolysis	9.3%
119	Spinal Diseases	9.3%
120	Synovitis	9.3%
121	Joint laxity	9.3%
122	Polyarthritis	9.3%
123	Frozen shoulder	9.3%
124	Patellofemoral Pain Syndrome	9.3%
125	Osteoarthritis, Knee	9.2%
126	Fetal Diseases	9.1%
127	Scimitar Syndrome	9%
128	Temporomandibular Joint Dysfunction Syndrome	9%
129	Polycystic Kidney Diseases	8.9%
130	Williams Syndrome	8.9%
131	Arthritis, Gouty	8.7%
132	Abnormalities, Radiation-Induced	8.6%
133	Dwarfism	8.6%
134	Fragile X Syndrome	8.4%
135	Alstrom Syndrome	8.4%
136	Blepharophimosis	8.3%
137	Laryngostenosis	8.3%
138	Mouth Abnormalities	8.3%
139	Esophageal Atresia	8.2%
140	Intestinal Atresia	8.2%
141	Horseshoe Kidney	8.2%
142	Muscular Dystrophy	8.2%
143	Basal Cell Nevus Syndrome	8.1%
144	Acrodermatitis	8.1%
145	Gigantism	8.1%
146	Lymphangiectasis, Intestinal	8.1%
147	Spinal Neoplasms	8.1%
148	Spondylitis	8.1%
149	Gianotti-Crosti Syndrome	8.1%
150	Arthritis, Psoriatic	8.1%
151	Rheumatoid Arthritis	8%
152	Juvenile arthritis	8%
153	Classical Lissencephalies and Subcortical Band Heterotopias	8%
154	Retinal Dysplasia	7.9%
155	Spondylarthropathies	7.9%
156	Aniridia	7.8%
157	Primary Ciliary Dyskinesia	7.8%
158	Epidermolysis Bullosa	7.7%
159	Ectopia Cordis	7.6%
160	Meningomyelocele	7.6%
161	Spina Bifida	7.6%
162	Single umbilical artery	7.6%
163	Arthritis, Reactive	7.5%
164	Osteogenesis Imperfecta	7.5%
165	Smith-Lemli-Opitz Syndrome	7.4%
166	Turner Syndrome	7.4%
167	Rheumatoid Nodule	7.3%
168	Bone Diseases, Endocrine	7.3%
169	Congenital Hypothyroidism	7.2%
170	Ichthyosis, X-Linked	7.2%
171	Muscular Dystrophy, Duchenne	7.2%
172	Cystic Fibrosis	7.1%
173	Bone Diseases, Infectious	7%
174	Bone neoplasms	7%
175	Compartment syndromes	7%
176	Maxillary Diseases	7%
177	Osteopenia	7%
178	Tendinitis	7%
179	Tendinopathy	7%
180	Myotonic Dystrophy	7%
181	Abdominal Cramps	7%
182	Amniotic Band Syndrome	7%
183	Asphyxia Neonatorum	7%
184	Choanal Atresia	7%
185	Infant, Premature, Diseases	7%
186	Tracheobronchomegaly	7%
187	Infantile Colic	7%
188	Laryngocele	7%
189	Bone Resorption	6.9%
190	Choledochal Cyst	6.9%
191	Hemarthrosis	6.9%
192	Hermaphroditism	6.9%
193	Myositis	6.9%
194	Disorders of Sex Development	6.9%
195	Tietze's Syndrome	6.9%
196	Isaacs syndrome	6.9%
197	Aseptic Necrosis of Bone	6.9%
198	Myotonic Disorders	6.9%
199	Ainhum	6.8%
200	Bunion	6.8%
201	Cryptorchidism	6.8%
202	Dysostoses	6.8%
203	Fibrodysplasia Ossificans Progressiva	6.8%
204	Myoglobinuria	6.8%
205	Myositis Ossificans	6.8%
206	Spinal Stenosis	6.8%
207	Spondylosis	6.8%
208	Tenosynovitis	6.8%
209	Intervertebral Disc Degeneration	6.8%
210	Sacroiliitis	6.8%
211	Hypospadias	6.8%
212	Central Nervous System Cysts	6.8%
213	Dandy-Walker Syndrome	6.7%
214	POEMS Syndrome	6.7%
215	Discitis	6.6%
216	Talipes	6.6%
217	Polycystic Kidney, Autosomal Dominant	6.5%
218	Klinefelter Syndrome	6.3%
219	Dermal Sinus	6.2%
220	Spina Bifida Cystica	6.2%
221	Spina Bifida Occulta	6.2%
222	Lissencephaly	6.2%
223	Polymicrogyria	6.2%
224	Pachygyria	6.2%
225	Schizencephaly	6.2%
226	Periventricular Nodular Heterotopia	6.2%
227	Familial Periodic Paralysis	6.2%
228	Felty Syndrome	6.1%
229	Aortic coarctation	6%
230	Cor Triatriatum	6%
231	Coronary Vessel Anomalies	6%
232	Dental Enamel Hypoplasia	6%
233	Patent ductus arteriosus	6%
234	Ebstein Anomaly	6%
235	Heart Septal Defects	6%
236	Hypodontia	6%
237	Macrostomia	6%
238	Meningocele	6%
239	Microstomia	6%
240	Tetralogy of Fallot	6%
241	Transposition of Great Vessels	6%
242	Hypoplastic Left Heart Syndrome	6%
243	May-Thurner Syndrome	6%
244	Encephalocele	6%
245	Pseudoxanthoma Elasticum	6%
246	Welander Distal Myopathy	6%
247	Wolff-Parkinson-White Syndrome	6%
248	Meconium Aspiration Syndrome	5.9%
249	Sjogren-Larsson Syndrome	5.8%
250	Bladder Exstrophy	5.8%
251	Epispadias	5.8%
252	Multicystic Dysplastic Kidney	5.8%
253	Charcot-Marie-Tooth Disease	5.6%
254	Chondrodysplasia Punctata	5.6%
255	Enchondromatosis	5.6%
256	Lordosis	5.6%
257	Osteosclerosis	5.6%
258	Spondylolysis	5.6%
259	kyphosis	5.6%
260	Kashin-Beck Disease	5.6%
261	Kallmann Syndrome	5.6%
262	Myotonia Congenita	5.6%
263	Medial Tibial Stress Syndrome	5.6%
264	Hyperkeratosis, Epidermolytic	5.5%
265	Mitochondrial Myopathies	5.5%
266	Tuberculosis, Spinal	5.5%
267	Neoplastic Syndromes, Hereditary	5.5%
268	Congenital clubfoot	5.4%
269	Vertical Talus	5.4%
270	Muscle Cramp	5.4%
271	Eosinophilia-Myalgia Syndrome	5.4%
272	Xeroderma Pigmentosum	5.4%
273	Muscle Rigidity	5.4%
274	Muscle Spasticity	5.4%
275	Cogwheel Rigidity	5.4%
276	Nuchal Rigidity	5.4%
277	Rheumatoid Vasculitis	5.2%
278	Anemia, Neonatal	5.2%
279	Arthritis, Infectious	5.2%
280	Pelger-Huet Anomaly	5.2%
281	Persistent Fetal Circulation Syndrome	5.2%
282	Werner Syndrome	5.2%
283	Myasthenic Syndromes, Congenital	5.2%
284	Umbilical hernia	5.1%
285	Anterior Compartment Syndrome	5.1%
286	Osteomyelitis	5.1%
287	Osteoporosis	5.1%
288	Periostitis	5.1%
289	Enthesopathy	5.1%
290	Bone Demineralization, Pathologic	5.1%
291	Post-Traumatic Osteoporosis	5.1%
292	Arthritis, Experimental	5.1%
293	Abdominal Compartment Syndrome	5.1%
294	Alveolar Bone Loss	5%
295	Femur Head Necrosis	5%
296	Polymyositis	5%
297	Osteolysis	5%
298	Long QT Syndrome	5%
299	Melorheostosis	5%
300	Osteopetrosis	5%
301	Spondylolisthesis	5%
302	Tricuspid Atresia	5%
303	Arrhythmogenic Right Ventricular Dysplasia	5%
304	Gonadal Dysgenesis	5%
305	Adrenogenital Syndrome	5%
306	Ovotesticular Disorders of Sex Development	5%
307	Zellweger Syndrome	5%
308	Aortopulmonary Septal Defect	5%
309	Double Outlet Right Ventricle	5%
310	Endocardial Cushion Defects	5%
311	Myocardial bridging	5%
312	Aorticopulmonary Septal Defect	5%
313	Hyperandrogenism	4.9%
314	Tuberous Sclerosis	4.8%
315	Chronic Fatigue Syndrome	4.8%
316	Hypokalemic periodic paralysis	4.7%
317	Giant Cell Epulis	4.6%
318	Muscle Weakness	4.6%
319	Sicca Syndrome	4.6%
320	Sjogren's Syndrome	4.6%
321	Familial Mediterranean Fever	4.5%
322	Musculoskeletal Pain	4.5%
323	Refsum Disease	4.5%
324	Arthralgia	4.5%
325	Polyarthralgia	4.5%
326	Anemia, Sickle Cell	4.5%
327	Thalassemia	4.5%
328	Truncus Arteriosus, Persistent	4.4%
329	Palatal Neoplasms	4.3%
330	Pseudohypoparathyroidism	4.3%
331	Neonatal Abstinence Syndrome	4.2%
332	Hip Dislocation	4.2%
333	Osteoporosis, Postmenopausal	4.2%
334	Shoulder Dislocation	4.2%
335	Hip Dysplasia	4.2%
336	Fetal Growth Retardation	4.1%
337	Romano-Ward Syndrome	4.1%
338	Albinism	4.1%
339	Fetal Hypoxia	4.1%
340	Congenital nystagmus	4.1%
341	Orbital Myositis	4.1%
342	Fetal Alcohol Spectrum Disorders	4.1%
343	Dupuytren Contracture	4.1%
344	Toxoplasmosis, Congenital	4%
345	Syphilis, Congenital	4%
346	Pyomyositis	4%
347	Acromegaly	4%
348	Joint Tuberculosis	4%
349	Tuberculosis, Osteoarticular	4%
350	Bone Tuberculosis	4%
351	Rett Syndrome	4%
352	Eosinophilic Granuloma	3.8%
353	Myalgia	3.8%
354	Mucopolysaccharidosis II	3.6%
355	Paralysis, Obstetric	3.4%
356	Retinopathy of Prematurity	3.4%
357	Autoimmune Lymphoproliferative Syndrome	3.4%
358	Congenital Hyperinsulinism	3.4%
359	Amino Acid Metabolism, Inborn Errors	3.4%
360	Carbohydrate Metabolism, Inborn Errors	3.4%
361	Chorioamnionitis	3.4%
362	Metal Metabolism, Inborn Errors	3.4%
363	Progeria	3.4%
364	Lysosomal Storage Diseases	3.4%
365	Cytochrome-c Oxidase Deficiency	3.4%
366	Peroxisomal Disorders	3.4%
367	Bronchopulmonary Dysplasia	3.4%
368	Angioedemas, Hereditary	3.4%
369	Rickets	3.3%
370	Wiskott-Aldrich Syndrome	3.3%
371	Mastoiditis	3.3%
372	Petrositis	3.3%
373	Shoulder Pain	3.3%
374	Sickle Cell Trait	3.3%
375	Menkes Kinky Hair Syndrome	3.3%
376	Arteriovenous fistula	3.1%
377	Neuronal Ceroid-Lipofuscinoses	3.1%
378	Mitochondrial Encephalomyopathies	2.8%
379	Dermatomyositis	2.8%
380	Respiratory Distress Syndrome, Newborn	2.8%
381	Cutis Laxa	2.7%
382	Osteomalacia	2.7%
383	Retinitis Pigmentosa	2.7%
384	Pigmentary retinopathy	2.7%
385	Porokeratosis	2.7%
386	Keratoderma, Palmoplantar	2.7%
387	Chronic granulomatous disease	2.7%
388	Adrenoleukodystrophy	2.6%
389	Amyloid Neuropathies, Familial	2.6%
390	Hepatolenticular Degeneration	2.5%
391	Acute Chest Syndrome	2.5%
392	Alkaptonuria	2.5%
393	Glycogen Storage Disease	2.5%
394	Hypophosphatasia	2.5%
395	Propionic acidemia	2.5%
396	Dihydropyrimidine Dehydrogenase Deficiency	2.5%
397	Cystinosis	2.5%
398	Ophthalmia Neonatorum	2.5%
399	Fabry Disease	2.5%
400	Galactosemias	2.5%
401	Urea Cycle Disorders, Inborn	2.5%
402	Tyrosinemias	2.5%
403	Denys-Drash Syndrome	2.4%
404	Glycogen storage disease type II	2.4%
405	Hydrops Fetalis	2.4%
406	MELAS Syndrome	2.4%
407	Mucopolysaccharidosis III	2.3%
408	Duane Retraction Syndrome	2.3%
409	Porphyrias, Hepatic	2.3%
410	Ataxia Telangiectasia	2.3%
411	Peutz-Jeghers Syndrome	2.2%
412	Thrombasthenia	2.2%
413	Antithrombin III Deficiency	2.2%
414	Protein C Deficiency	2.2%
415	Brain Diseases, Metabolic, Inborn	2.2%
416	Afibrinogenemia	2.2%
417	Dystonia Musculorum Deformans	2.2%
418	Factor VII Deficiency	2.2%
419	Factor X Deficiency	2.2%
420	Factor XII Deficiency	2.2%
421	Hemophilia A	2.2%
422	Leukomalacia, Periventricular	2.2%
423	Activated Protein C Resistance	2.2%
424	Factor II deficiency	2.2%
425	Factor VIII Deficiency	2.2%
426	Factor V deficiency	2.2%
427	Factor XI Deficiency	2.2%
428	Hypoprothrombinemias	2.2%
429	Fanconi Anemia	2.2%
430	Nesidioblastosis	2.2%
431	Lafora Disease	2.2%
432	Unverricht-Lundborg Syndrome	2.2%
433	Anemia, Diamond-Blackfan	2.2%
434	Optic Atrophy, Hereditary, Leber	2.2%
435	Hyperphosphaturia	2.2%
436	Familial Hypophosphatemic Rickets	2.2%
437	Canavan Disease	2.1%
438	Alexander Disease	2.1%
439	Radicular Cyst	2.1%
440	Glycogen Storage Disease Type I	2.1%
441	Glycogen Storage Disease Type V	2.1%
442	Hyaline Membrane Disease	2%
443	Homocystinuria	2%
444	Leigh Disease	2%
445	Hypolipoproteinemias	2%
446	Papillon-Lefevre Disease	2%
447	Hyperlipidemia, Familial Combined	2%
448	Multiple Endocrine Neoplasia	2%
449	Hyperlipoproteinemia Type III	2%
450	Gaucher Disease	2%
451	Dermatitis, Atopic	1.9%
452	Nose Neoplasms	1.9%
453	Renal Osteodystrophy	1.8%
454	Renal rickets	1.8%
455	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
456	Tay-Sachs Disease	1.8%
457	Niemann-Pick Disease, Type C	1.7%
458	Kernicterus	1.7%
459	Behcet Syndrome	1.7%
460	Lactose Intolerance	1.7%
461	Variegate Porphyria	1.7%
462	Acute intermittent porphyria	1.7%
463	Porphyria Cutanea Tarda	1.7%
464	Hyperhomocysteinemia	1.7%
465	Renal Aminoacidurias	1.6%
466	Fanconi Syndrome	1.6%
467	Pseudohypoaldosteronism	1.6%
468	Liddle Syndrome	1.6%
469	Hypoalphalipoproteinemias	1.6%
470	Hyperlipoproteinemia Type IV	1.6%
471	Hyperlipoproteinemia Type V	1.6%
472	Huntington Disease	1.5%
473	Multiple Endocrine Neoplasia Type 1	1.4%
474	Friedreich Ataxia	1.4%
475	Renal tubular acidosis	1.4%
476	Cystinuria	1.4%
477	Kearns-Sayre syndrome	1.4%
478	Nephroblastoma	1.3%
479	Adenomatous Polyposis Coli	1.2%
480	Glycosuria, Renal	1.1%

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