MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leukoencephalopathy

(UMLS:C0270612)

Definition:: Any of various diseases affecting the white matter of the central nervous system.
UMLS ID:: C0270612
MeSH ID:: D056784

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.695

Synonym(s)

Leukoencephalopathy

BRAIN WHITE MATTER DISEASE

Brain syndrome, white matter

Leukoencephalopathy, NOS

White matter disease

White matter of brain syndrome, NOS

brain disease matter white

leukoencephalopathies

leukoencephalopathy

10.

white matter disease

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Methotrexate	FAERS: 70 Canada Vigilance: 5	Canada Vigilance OFFSIDES SIDER US FAERS
2	Cyclosporine	FAERS: 29	OFFSIDES US FAERS
3	Capecitabine	FAERS: 27	US FAERS
4	Morphine	FAERS: 26	OFFSIDES US FAERS
5	Sunitinib	FAERS: 19	US FAERS
6	Fentanyl	FAERS: 18	US FAERS
7	Methadone	FAERS: 18	OFFSIDES US FAERS
8	Tacrolimus	FAERS: 17	SIDER US FAERS
9	Methadone	FAERS: 13	US FAERS
10	Fluorouracil	FAERS: 12	OFFSIDES US FAERS
11	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 11	OFFSIDES US FAERS
12	Sorafenib	FAERS: 11	SIDER US FAERS
13	Methotrexate	FAERS: 10	US FAERS
14	Metronidazole	FAERS: 9	US FAERS
15	Bortezomib	FAERS: 8	OFFSIDES US FAERS
16	Levamisole	FAERS: 8	US FAERS
17	Temozolomide	FAERS: 8	US FAERS
18	fludarabine	FAERS: 8	US FAERS
19	Axitinib	FAERS: 7	US FAERS
20	Sunitinib	FAERS: 7	OFFSIDES US FAERS
21	gemcitabine	FAERS: 7	US FAERS
22	rofecoxib	FAERS: 7	US FAERS
23	Oxycodone	FAERS: 6	US FAERS
24	Everolimus	FAERS: 5	US FAERS
25	Gefitinib	FAERS: 5 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
26	nelarabine	FAERS: 5	OFFSIDES SIDER US FAERS
27	Diclofenac	FAERS: 4	OFFSIDES US FAERS
28	Docetaxel	FAERS: 4	US FAERS
29	Mycophenolic Acid	FAERS: 4	US FAERS
30	Ruxolitinib phosphate	FAERS: 4	US FAERS
31	lenvatinib	FAERS: 4	US FAERS
32	Azacitidine	FAERS: 3	OFFSIDES US FAERS
33	Buprenorphine	FAERS: 3	US FAERS
34	Deferasirox	FAERS: 3	US FAERS
35	Doxorubicin	FAERS: 3	OFFSIDES US FAERS
36	PCI 32765	FAERS: 3	US FAERS
37	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2	OFFSIDES US FAERS
38	Afatinib	FAERS: 2	US FAERS
39	Alprostadil	FAERS: 2	US FAERS
40	Amiodarone	FAERS: 2	US FAERS
41	Crizotinib	FAERS: 2	US FAERS
42	Cytarabine	FAERS: 2	OFFSIDES SIDER US FAERS
43	Dasatinib	FAERS: 2	US FAERS
44	Estradiol	FAERS: 2	US FAERS
45	Imatinib Mesylate	FAERS: 2	US FAERS
46	Lapatinib	FAERS: 2	US FAERS
47	Leucovorin	FAERS: 2	US FAERS
48	Levamisole	FAERS: 2	US FAERS
49	Levetiracetam	FAERS: 2	OFFSIDES US FAERS
50	Linezolid	FAERS: 2	OFFSIDES US FAERS
51	Meropenem	FAERS: 2	US FAERS
52	Midodrine	FAERS: 2	US FAERS
53	Pemetrexed	FAERS: 2	US FAERS
54	Sirolimus	FAERS: 2	US FAERS
55	Sitagliptin Phosphate	FAERS: 2	US FAERS
56	Tadalafil	FAERS: 2	OFFSIDES US FAERS
57	Thalidomide	FAERS: 2	OFFSIDES US FAERS
58	Valacyclovir	FAERS: 2	US FAERS
59	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
60	Voriconazole	FAERS: 2	OFFSIDES US FAERS
61	carbidopa, levodopa drug combination	FAERS: 2	US FAERS
62	carfilzomib	FAERS: 2	US FAERS
63	osimertinib	FAERS: 2	US FAERS
64	pazopanib	FAERS: 2	US FAERS
65	peramivir	FAERS: 2	US FAERS
66	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
67	5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine	FAERS: 1	US FAERS
68	Alprazolam	FAERS: 1	US FAERS
69	Amlodipine	FAERS: 1	US FAERS
70	Anastrozole	FAERS: 1	US FAERS
71	Azathioprine	FAERS: 1	US FAERS
72	Bendamustine Hydrochloride	FAERS: 1	US FAERS
73	Bromocriptine	FAERS: 1	US FAERS
74	Buprenorphine	FAERS: 1	US FAERS
75	Cabergoline	FAERS: 1	US FAERS
76	Carboplatin	FAERS: 1	US FAERS
77	Carboplatin	FAERS: 1	US FAERS
78	Chlorambucil	FAERS: 1	OFFSIDES US FAERS
79	Cilostazol	FAERS: 1	US FAERS
80	Citalopram	FAERS: 1	US FAERS
81	Clonazepam	FAERS: 1	OFFSIDES US FAERS
82	Dabigatran	FAERS: 1	US FAERS
83	Daunorubicin	FAERS: 1	US FAERS
84	Dexamethasone	FAERS: 1	US FAERS
85	Diazepam	FAERS: 1	OFFSIDES US FAERS
86	Dimethyl Fumarate	FAERS: 1	US FAERS
87	Diovan Hct	FAERS: 1	US FAERS
88	Donepezil	FAERS: 1	US FAERS
89	Dutasteride	FAERS: 1	US FAERS
90	Erlotinib Hydrochloride	FAERS: 1	US FAERS
91	Fingolimod Hydrochloride	FAERS: 1	US FAERS
92	Foscarnet	FAERS: 1	US FAERS
93	Glatiramer Acetate	FAERS: 1	US FAERS
94	Hydroxyurea	FAERS: 1	US FAERS
95	Idarubicin	FAERS: 1	US FAERS
96	Interferon alpha-2	FAERS: 1	US FAERS
97	Irinotecan	FAERS: 1	US FAERS
98	Irinotecan	FAERS: 1	US FAERS
99	Isotretinoin	FAERS: 1	US FAERS
100	Lamotrigine	FAERS: 1	US FAERS
101	Leflunomide	FAERS: 1	OFFSIDES US FAERS
102	Lenalidomide	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
103	Levodopa	FAERS: 1	OFFSIDES US FAERS
104	Lopinavir	FAERS: 1	OFFSIDES US FAERS
105	MDV 3100	FAERS: 1	US FAERS
106	Maloprim	FAERS: 1	OFFSIDES US FAERS
107	Melphalan	FAERS: 1	OFFSIDES US FAERS
108	Metformin	FAERS: 1	US FAERS
109	Ondansetron	FAERS: 1	US FAERS
110	Phenytoin	FAERS: 1	OFFSIDES US FAERS
111	Pregabalin	FAERS: 1	US FAERS
112	Risperidone	FAERS: 1	US FAERS
113	Tegafur	FAERS: 1	OFFSIDES US FAERS
114	Tenofovir	FAERS: 1	US FAERS
115	Thyroxine	FAERS: 1	US FAERS
116	Warfarin	FAERS: 1	US FAERS
117	Warfarin	FAERS: 1	US FAERS
118	apremilast	FAERS: 1	US FAERS
119	bicalutamide	FAERS: 1	US FAERS
120	cerivastatin	FAERS: 1	US FAERS
121	eribulin	FAERS: 1	US FAERS
122	fludarabine phosphate	FAERS: 1	US FAERS
123	gemcitabine	FAERS: 1	OFFSIDES US FAERS
124	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
125	liposomal amphotericin B	FAERS: 1	OFFSIDES US FAERS
126	liposomal doxorubicin	FAERS: 1	US FAERS
127	palbociclib	FAERS: 1	US FAERS
128	sofosbuvir-velpatasvir drug combination	FAERS: 1	US FAERS
129	temsirolimus	FAERS: 1	US FAERS
130	5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride		OFFSIDES
131	Acamprosate		OFFSIDES
132	Acetazolamide		OFFSIDES
133	Acyclovir		OFFSIDES
134	Adenosine		OFFSIDES
135	Alcohols		OFFSIDES
136	Alfentanil		OFFSIDES
137	Amantadine		OFFSIDES
138	Aminocaproic Acid		OFFSIDES
139	Amitriptyline		OFFSIDES
140	Amoxapine		OFFSIDES
141	Amphetamine		OFFSIDES
142	Ampicillin		OFFSIDES
143	Aspirin		OFFSIDES
144	Atazanavir Sulfate		OFFSIDES
145	Atenolol		OFFSIDES
146	Atomoxetine Hydrochloride		OFFSIDES
147	Atorvastatin		OFFSIDES
148	Atropine		OFFSIDES
149	Baclofen		OFFSIDES
150	Beclomethasone		OFFSIDES
151	Betamethasone Valerate		OFFSIDES
152	Bisacodyl		OFFSIDES
153	Bumetanide		OFFSIDES
154	Bupropion		OFFSIDES
155	Caffeine		OFFSIDES
156	Calcium Citrate		OFFSIDES
157	Carbamazepine		OFFSIDES
158	Cefdinir		OFFSIDES
159	Cefotaxime		OFFSIDES
160	Cefuroxime		OFFSIDES
161	Cephalexin		OFFSIDES
162	Cetirizine		OFFSIDES
163	Chlorhexidine		OFFSIDES
164	Chlorpromazine		OFFSIDES
165	Cidofovir		OFFSIDES
166	Citalopram		OFFSIDES
167	Clindamycin		OFFSIDES
168	Clobazam		OFFSIDES
169	Clomipramine		OFFSIDES
170	Clopidogrel		OFFSIDES
171	Clorazepate Dipotassium		OFFSIDES
172	Clotrimazole		OFFSIDES
173	Clozapine		OFFSIDES
174	Cocaine	Canada Vigilance: 2	Canada Vigilance
175	Codeine		OFFSIDES
176	Cyclizine		OFFSIDES
177	Cyclopentolate		OFFSIDES
178	Dextromethorphan		OFFSIDES
179	Dilazep		OFFSIDES
180	Dioctyl Sulfosuccinic Acid		OFFSIDES
181	Disulfiram		OFFSIDES
182	Dobutamine		OFFSIDES
183	Donepezil		OFFSIDES
184	Doxycycline		OFFSIDES
185	Epinephrine		OFFSIDES
186	Eptifibatide		OFFSIDES
187	Ertapenem		OFFSIDES
188	Estazolam		OFFSIDES
189	Estramustine phosphate		OFFSIDES
190	Estramustine		OFFSIDES
191	Ethylene Glycol		OFFSIDES
192	Etomidate		OFFSIDES
193	Etoposide		OFFSIDES
194	Flecainide		OFFSIDES
195	Fluconazole		OFFSIDES
196	Fludrocortisone		OFFSIDES
197	Flunitrazepam		OFFSIDES
198	Flupenthixol		OFFSIDES
199	Flurazepam		OFFSIDES
200	Foscarnet		OFFSIDES
201	Furosemide		OFFSIDES
202	Gabapentin		OFFSIDES
203	Gabexate		OFFSIDES
204	Ganciclovir		OFFSIDES
205	Glycopyrrolate		OFFSIDES
206	Heroin		OFFSIDES
207	Hydrocortisone		OFFSIDES
208	Hydrocortisone sodium succinate		OFFSIDES
209	Hydron;carbonate		OFFSIDES
210	Hydroxychloroquine		OFFSIDES
211	Hydroxyzine		OFFSIDES
212	Idarubicin		OFFSIDES
213	Ifosfamide		OFFSIDES SIDER
214	Imipramine		OFFSIDES
215	Indomethacin		OFFSIDES
216	Ioxaglic Acid		OFFSIDES
217	Isoflurane		OFFSIDES
218	Ivermectin		OFFSIDES
219	Lactulose		OFFSIDES
220	Latanoprost		OFFSIDES
221	Lithium Carbonate		OFFSIDES
222	Lithium		OFFSIDES
223	Magnesium		OFFSIDES
224	Medroxyprogesterone Acetate		OFFSIDES
225	Medroxyprogesterone		OFFSIDES
226	Mefenamic Acid		OFFSIDES
227	Mercaptopurine		OFFSIDES
228	Mesna		OFFSIDES
229	Methylene Blue		OFFSIDES
230	Methyltestosterone		OFFSIDES
231	Metolazone		OFFSIDES
232	Metoprolol		OFFSIDES
233	Mianserin		OFFSIDES
234	Midodrine		OFFSIDES
235	Misoprostol		OFFSIDES
236	Modafinil		OFFSIDES
237	Molsidomine		OFFSIDES
238	Mometasone Furoate		OFFSIDES
239	Nafronyl		OFFSIDES
240	Nateglinide		OFFSIDES
241	Nefopam		OFFSIDES
242	Nevirapine		OFFSIDES
243	Nicardipine		OFFSIDES
244	Nitrendipine		OFFSIDES
245	Nizatidine		OFFSIDES
246	Norfloxacin		OFFSIDES
247	Ofloxacin		OFFSIDES
248	Opalmon		OFFSIDES
249	Oxazepam		OFFSIDES
250	Oxcarbazepine		OFFSIDES
251	Paclitaxel		SIDER
252	Pamidronate		OFFSIDES
253	Paroxetine		OFFSIDES
254	Penicillin G		OFFSIDES
255	Penicillin V		OFFSIDES
256	Phenobarbital		OFFSIDES
257	Pindolol		OFFSIDES
258	Piperacillin		OFFSIDES
259	Piracetam		OFFSIDES
260	Piroxicam		OFFSIDES
261	Polymyxin B		OFFSIDES
262	Potassium		OFFSIDES
263	Prednisone acetate		OFFSIDES
264	Primidone		OFFSIDES
265	Procyclidine		OFFSIDES
266	Promazine		OFFSIDES
267	Promethazine		OFFSIDES
268	Propofol		OFFSIDES
269	Pyridoxine		OFFSIDES
270	Ramipril		OFFSIDES
271	Ranolazine		OFFSIDES
272	Reboxetine		OFFSIDES
273	Remifentanil		OFFSIDES
274	Rifampin		OFFSIDES
275	Rilmenidine		OFFSIDES
276	Rocuronium		OFFSIDES
277	Sevelamer		OFFSIDES
278	Sevelamer		OFFSIDES
279	Sevoflurane		OFFSIDES
280	Sodium Bicarbonate		OFFSIDES
281	Sodium picosulfate		OFFSIDES
282	Succinylcholine		OFFSIDES
283	Sufentanil		OFFSIDES
284	Sulfamethoxazole		OFFSIDES
285	Sulpiride		OFFSIDES
286	Sumatriptan		OFFSIDES
287	Tazobactam		OFFSIDES
288	Terazosin		OFFSIDES
289	Terbutaline		OFFSIDES
290	Thioguanine		OFFSIDES
291	Thiotepa		OFFSIDES
292	Tiagabine		OFFSIDES
293	Tigecycline		OFFSIDES
294	Tobramycin		OFFSIDES
295	Trimetazidine		OFFSIDES
296	Trimethoprim, Sulfamethoxazole Drug Combination		OFFSIDES
297	Trimipramine		OFFSIDES
298	Vancomycin		OFFSIDES
299	Vecuronium Bromide		OFFSIDES
300	Vincristine		OFFSIDES
301	Vitamin D		OFFSIDES
302	Vitamin E Nicotinate		OFFSIDES
303	Zonisamide		OFFSIDES
304	abacavir		OFFSIDES
305	alfacalcidol		OFFSIDES
306	alfuzosin		OFFSIDES
307	alpha-Tocopherol		OFFSIDES
308	amprenavir		OFFSIDES
309	atovaquone, proguanil drug combination		OFFSIDES
310	benzonatate		OFFSIDES
311	binedaline		OFFSIDES
312	bromopride		OFFSIDES
313	buflomedil		OFFSIDES
314	candesartan cilexetil		OFFSIDES
315	candesartan		OFFSIDES
316	chlorhexidine gluconate		OFFSIDES
317	cyclobenzaprine		OFFSIDES
318	distigmine		OFFSIDES
319	erythromycin lactobionate		OFFSIDES
320	ethyl loflazepate		OFFSIDES
321	etizolam		OFFSIDES
322	fosamprenavir		OFFSIDES
323	gadobenic acid		OFFSIDES
324	itopride		OFFSIDES
325	lafutidine		OFFSIDES
326	limaprost		OFFSIDES
327	mebeverine		OFFSIDES
328	mecobalamin		OFFSIDES
329	miglustat		OFFSIDES
330	nafamostat		OFFSIDES
331	naratriptan		OFFSIDES
332	pirarubicin		OFFSIDES
333	posaconazole		OFFSIDES
334	reviparin		OFFSIDES
335	spironolactone, althiazide drug combination		OFFSIDES
336	telmisartan, hydrochlorothiazide drug combination		OFFSIDES
337	tipepidine		OFFSIDES
338	tipranavir		OFFSIDES
339	tizanidine		OFFSIDES
340	zafirlukast		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Akinetic Mutism	46.7%
2	Anoxic Encephalopathy	46.7%
3	Basal Ganglia Diseases	46.7%
4	Brain Damage, Chronic	46.7%
5	Cerebellar Diseases	46.7%
6	Encephalitis	46.7%
7	Encephalomalacia	46.7%
8	Epilepsy	46.7%
9	Hydrocephalus	46.7%
10	Congenital Hydrocephalus	46.7%
11	Hypothalamic Diseases	46.7%
12	Thalamic Diseases	46.7%
13	Intracranial Hypertension	46.7%
14	Aura	46.7%
15	Neuroaxonal Dystrophies	46.7%
16	Headache Disorders	46.7%
17	Intracranial Hypotension	46.7%
18	Brain Edema	46.7%
19	Brain Hypoxia	46.7%
20	Aqueductal Stenosis	46.7%
21	Subdural Effusion	40.7%
22	Myoclonic Epilepsy	37.6%
23	Epilepsy, Temporal Lobe	37.6%
24	Epilepsy, Rolandic	37.6%
25	Benign Rolandic Epilepsy	37.6%
26	Parkinsonian Disorders	36.3%
27	Meningoencephalitis	35.5%
28	Cerebral Palsy	34.4%
29	Epilepsies, Partial	34.4%
30	Epilepsy, Generalized	34.4%
31	Pseudotumor Cerebri	34.4%
32	Hypertensive Encephalopathy	34.4%
33	Simple Partial Seizures	34.4%
34	Epilepsy, Reflex	34.4%
35	Basal Ganglia Cerebrovascular Disease	34.4%
36	Headache Disorders, Primary	34.4%
37	Headache Disorders, Secondary	34.4%
38	Medication overuse headache	34.4%
39	Encephalomyelitis	34.1%
40	Juvenile Myoclonic Epilepsy	33.7%
41	Myoclonic Epilepsies, Progressive	33.7%
42	Meige Syndrome	32.6%
43	Cerebral Ventriculitis	32.6%
44	Dandy-Walker Syndrome	32%
45	Brain Diseases, Metabolic	31.8%
46	Cerebrovascular Disorders	31.8%
47	Cerebrovascular Insufficiency	31.8%
48	Dementia	31.8%
49	Vascular Headaches	31.4%
50	Hypoxia-Ischemia, Brain	31.2%
51	Meningitis	31%
52	Movement Disorders	31%
53	Pachymeningitis	31%
54	Spinal Cord Diseases	31%
55	Marchiafava-Bignami Disease	30.3%
56	Lewy Body Disease	29.5%
57	Epilepsy, Post-Traumatic	29.2%
58	Multiple System Atrophy	28.9%
59	Post-Traumatic Headache	28.5%
60	Tension Headache	28.5%
61	Epilepsy, Complex Partial	28.5%
62	Migraine Disorders	28.5%
63	Abdominal Migraine	28.5%
64	Status Migrainosus	28.5%
65	Cervicogenic Headache	28.5%
66	Pneumocephalus	27.8%
67	Leukomalacia, Periventricular	27.6%
68	Parkinson Disease	27%
69	Brain Abscess	26.8%
70	Myelitis	26.7%
71	Brain Injuries	26.7%
72	Brain Neoplasms	26.4%
73	Cerebellar Neoplasms	26.3%
74	Cluster Headache	25.5%
75	Migraine with Aura	25.5%
76	Familial Hemiplegic Migraine	25.5%
77	Chronic Paroxysmal Hemicrania	25.5%
78	SUNCT Syndrome	25.5%
79	Paroxysmal Hemicrania	25.5%
80	Brain Death	24.8%
81	Pituitary Diseases	24.7%
82	Creutzfeldt-Jakob disease	24.6%
83	Dementia, Vascular	23.3%
84	Basal Ganglia Hemorrhage	23.2%
85	Carotid Artery Diseases	23.1%
86	Brain Ischemia	23.1%
87	Cerebrovascular accident	23.1%
88	Kluver-Bucy Syndrome	23.1%
89	Vasospasm, Intracranial	23.1%
90	Intracranial Arterial Diseases	23.1%
91	Pituitary Apoplexy	23%
92	Neuroleptic Malignant Syndrome	22.7%
93	Myelinolysis, Central Pontine	22.7%
94	Brain Infarction	22.6%
95	Dystonia Musculorum Deformans	22.4%
96	Huntington Disease	22%
97	Central Nervous System Infection	22%
98	Lafora Disease	22%
99	Unverricht-Lundborg Syndrome	22%
100	Striatonigral Degeneration	21.8%
101	Ocular Motility Disorders	21.8%
102	Cyclophoria	21.8%
103	Epidural Abscess	21.7%
104	Putaminal Hemorrhage	21%
105	Presenile dementia	20.7%
106	Senile dementia	20.7%
107	Infarction, Middle Cerebral Artery	20.6%
108	Infarction, Anterior Cerebral Artery	20.6%
109	Infarction, Posterior Cerebral Artery	20.6%
110	Amblyopia	20.6%
111	Prion Diseases	20.5%
112	Cerebral Infarction	20.1%
113	Brain Stem Infarctions	20.1%
114	Arachnoiditis	20%
115	Aseptic Meningitis	20%
116	Syringomyelia	20%
117	Essential Tremor	20%
118	Familial Tremor	20%
119	Pneumorrhachis	20%
120	Writer's Cramp	20%
121	Empty Sella Syndrome	19.6%
122	Hyperpituitarism	19.6%
123	Hypopituitarism	19.6%
124	Hypophysitis	19.6%
125	Brain Injuries, Diffuse	19.5%
126	Traumatic Brain Injury	19.5%
127	Cerebellar Ataxia	19.4%
128	Supratentorial Neoplasms	19.4%
129	MPTP Poisoning	19.3%
130	Pituitary Adenoma	19.3%
131	Pituitary Neoplasms	19.3%
132	Cerebral Arterial Diseases	18.9%
133	Vertebrobasilar Insufficiency	18.9%
134	Lateral Medullary Syndrome	18.9%
135	Basilar Artery Stenosis	18.9%
136	Vertebral Artery Stenosis	18.9%
137	Intracranial Hemorrhage, Hypertensive	18.9%
138	Posterior Leukoencephalopathy Syndrome	18.9%
139	Transient Cerebral Ischemia	18.9%
140	Posterior reversible encephalopathy syndrome	18.9%
141	Persistent Vegetative State	18.9%
142	Limbic Encephalitis	18.6%
143	Cranial nerve diseases	18.5%
144	Demyelinating Diseases	18.5%
145	Demyelination	18.5%
146	Neuromuscular Diseases	18.5%
147	Chronobiology Disorders	18.5%
148	Shy-Drager Syndrome	18.3%
149	Carotid Artery Injuries	18.1%
150	Moyamoya Disease	17.9%
151	Progressive supranuclear palsy	17.6%
152	Lupus Vasculitis, Central Nervous System	17.5%
153	Reye Syndrome	17.4%
154	Meningitis, Bacterial	17.4%
155	Meningitis, Fungal	17.4%
156	Brain Hemorrhage, Traumatic	17.2%
157	Intracranial Embolism and Thrombosis	17.2%
158	Hepatic Encephalopathy	17.2%
159	Hyperprolactinemia	17.2%
160	Subclavian Steal Syndrome	16.9%
161	Pick Disease of the Brain	16.9%
162	Spinal Muscular Atrophy	16.7%
163	Progressive Muscular Atrophy	16.7%
164	Amnesia, Transient Global	16.6%
165	Paraneoplastic Cerebellar Degeneration	16.4%
166	Stiff-Person Syndrome	16.4%
167	Spinal Cord Injuries	16.1%
168	Diffuse Axonal Injury	16.1%
169	Brain Stem Neoplasms	16%
170	Friedreich Ataxia	16%
171	Poliomyelitis	15.9%
172	Asterixis	15.3%
173	Ballismus	15.3%
174	Toxoplasmosis, Cerebral	15.2%
175	Vasculitis, Central Nervous System	15.1%
176	Hepatolenticular Degeneration	14.9%
177	Choroid Plexus Papilloma	14.4%
178	Carotid Stenosis	14.3%
179	Intracranial Aneurysm	14.3%
180	Intracranial Arteriosclerosis	14.2%
181	Cerebral Atherosclerosis	14.2%
182	Subarachnoid Hemorrhage	14.2%
183	Cerebral Arteriosclerosis	14.2%
184	Cerebral Hemorrhage	14.2%
185	Cerebral Thrombosis	14.1%
186	Intracranial Embolism	14.1%
187	Intracranial Thrombosis	14.1%
188	Ophthalmoplegic Migraine	14%
189	Motor Neuron Disease	14%
190	Brain Diseases, Metabolic, Inborn	13.9%
191	Subarachnoid Hemorrhage, Traumatic	13.8%
192	Carotid Artery, Internal, Dissection	13.8%
193	Central Nervous System Fungal Infections	13.6%
194	Conus Medullaris Syndrome	13.6%
195	Spinal Cord Vascular Diseases	13.6%
196	Subacute Combined Degeneration	13.5%
197	Amyotrophic Lateral Sclerosis	13.3%
198	Frontotemporal dementia	13.2%
199	Spinal Cord Neoplasms	13.2%
200	Miller Fisher Syndrome	13.2%
201	Mitochondrial Encephalomyopathies	13.1%
202	Brain Contusion	12.9%
203	Acromegaly	12.9%
204	Chronic Fatigue Syndrome	12.9%
205	Tuberculosis, Meningeal	12.8%
206	Trauma, Nervous System	12.8%
207	Subacute Sclerosing Panencephalitis	12.7%
208	Cerebral Amyloid Angiopathy	12.7%
209	Sinus Thrombosis, Intracranial	12.6%
210	Leukoencephalopathy, Progressive Multifocal	12.3%
211	Nervous System Neoplasms	12.2%
212	Neurologic Manifestations	12.2%
213	Neurotoxicity Syndromes	12.2%
214	MELAS Syndrome	12.1%
215	Cavernous Sinus Thrombosis	11.9%
216	Sagittal Sinus Thrombosis	11.9%
217	Vertebral Artery Dissection	11.7%
218	Wernicke Encephalopathy	11.5%
219	AIDS Dementia Complex	11.4%
220	Autonomic Dysreflexia	11.4%
221	Complex Regional Pain Syndromes	11.4%
222	Carotid Artery Thrombosis	11.3%
223	Auditory Perceptual Disorders	11.2%
224	Myelitis, Transverse	10.9%
225	Scrapie	10.9%
226	Central Cord Syndrome	10.9%
227	Meningitis, Cryptococcal	10.7%
228	Meningitis, Listeria	10.7%
229	Chorea	10.7%
230	Meningitis, Haemophilus	10.6%
231	Meningitis, Pneumococcal	10.6%
232	Brain Concussion	10.6%
233	Dysautonomia	10.3%
234	Vagus Nerve Disorder	10.3%
235	Glossopharyngeal Neuralgia	10.3%
236	Abducens Nerve Diseases	10.3%
237	Heavy Metal Poisoning, Nervous System	10.3%
238	Neuromuscular Junction Diseases	10.3%
239	Central Nervous System Bacterial Infections	10.3%
240	Tauopathies	10.3%
241	Trochlear Nerve Diseases	10.3%
242	Peripheral Nervous System Diseases	10.3%
243	West Nile Fever	10.2%
244	Polyradiculoneuropathy	10.2%
245	Polyradiculoneuritis	10.2%
246	Akathisia, Drug-Induced	10.1%
247	Ataxia Telangiectasia	10.1%
248	Kernicterus	10%
249	Alice in Wonderland Syndrome	10%
250	Spinal Cord Ischemia	9.9%
251	Torticollis	9.7%
252	Tuberculosis, Central Nervous System	9.7%
253	Restless Legs Syndrome	9.7%
254	Opsoclonus-Myoclonus Syndrome	9.6%
255	Nelson Syndrome	9.6%
256	Sleep Wake Disorders	9.3%
257	Dyskinesia, Drug-Induced	9.1%
258	Progressive bulbar palsy	8.9%
259	Bulbar palsy	8.9%
260	Giant Cell Arteritis	8.8%
261	Temporal Arteritis	8.8%
262	Hematoma, Subdural	8.6%
263	Hematoma, Epidural, Cranial	8.6%
264	Peripheral Nerve Injuries	8.6%
265	Prolactinoma	8.6%
266	Growth Hormone-Secreting Pituitary Adenoma	8.6%
267	Canavan Disease	8.6%
268	Alexander Disease	8.6%
269	Myasthenia Gravis	8.5%
270	Tardive Dyskinesia	8.5%
271	Causalgia	8.2%
272	Anterior Spinal Artery Syndrome	8.1%
273	Galactosemias	8.1%
274	Urea Cycle Disorders, Inborn	8.1%
275	Tyrosinemias	8.1%
276	Guillain-Barre Syndrome	7.9%
277	Fabry Disease	7.9%
278	Hematoma, Subdural, Intracranial	7.9%
279	Hematoma, Subdural, Chronic	7.9%
280	Hematoma, Subdural, Acute	7.9%
281	Reflex Sympathetic Dystrophy	7.7%
282	Nocturnal Myoclonus Syndrome	7.7%
283	Adrenoleukodystrophy	7.5%
284	Neuroaspergillosis	7.4%
285	Myopathy	7.3%
286	Optic Neuropathy	7.3%
287	Refsum Disease	7.3%
288	Olfactory Nerve Injuries	7.2%
289	Homocystinuria	7.1%
290	Leigh Disease	7.1%
291	Sleep Disorders, Circadian Rhythm	7%
292	Facial Nerve Diseases	7%
293	Craniocerebral Trauma	7%
294	Parasomnia	7%
295	Dyssomnias	7%
296	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.9%
297	Vestibulocochlear Nerve Diseases	6.8%
298	Decerebrate State	6.8%
299	Hemiparesis	6.8%
300	Hydranencephaly	6.8%
301	Meningism	6.8%
302	Neural Tube Defects	6.8%
303	Paresis	6.8%
304	Seizures	6.8%
305	Sensation Disorders	6.8%
306	Tethered Cord Syndrome	6.8%
307	Central Nervous System Neoplasms	6.8%
308	Complex partial seizures	6.8%
309	Iniencephaly	6.8%
310	Craniorachischisis	6.8%
311	Exencephaly	6.8%
312	Monoparesis	6.8%
313	Septo-Optic Dysplasia	6.8%
314	Cortical Dysplasia	6.8%
315	Neurogenic Inflammation	6.8%
316	Gait Disorders, Neurologic	6.8%
317	Neuromuscular Manifestations	6.8%
318	Malformations of Cortical Development	6.8%
319	Sweating, Gustatory	6.7%
320	Auriculotemporal Syndrome	6.7%
321	Botulism	6.7%
322	Central Nervous System Cysts	6.7%
323	Lambert-Eaton Myasthenic Syndrome	6.7%
324	Neuritis	6.7%
325	Polyneuritis	6.7%
326	Radiculitis	6.7%
327	Polyneuropathy	6.7%
328	Mononeuritis	6.7%
329	Mononeuropathies	6.7%
330	Brachial Plexus Neuropathies	6.7%
331	Radiculopathy	6.7%
332	Mononeuropathy Multiplex	6.7%
333	Nerve Root Compression	6.7%
334	Multiple Sclerosis	6.6%
335	Brachial Plexus Neuritis	6.5%
336	Neuralgic Amyotrophy	6.5%
337	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.3%
338	Pseudorabies	6.3%
339	Toxoplasmosis, Congenital	6.2%
340	Malaria, Cerebral	6.2%
341	Neuromyelitis Optica	6.2%
342	Neurocysticercosis	6.1%
343	Facial Nerve Injuries	6%
344	Horner Syndrome	6%
345	Tarsal Tunnel Syndrome	5.9%
346	Cauda Equina Syndrome	5.9%
347	Menkes Kinky Hair Syndrome	5.9%
348	Neurosyphilis	5.8%
349	Acrodynia	5.7%
350	Glycogen storage disease type II	5.6%
351	Ophthalmoplegia	5.4%
352	External Ophthalmoplegia	5.4%
353	Pupil Disorders	5.4%
354	Neurobehavioral Manifestations	5.4%
355	Encephalomyelitis, Acute Disseminated	5.2%
356	Zellweger Syndrome	5.2%
357	Paraneoplastic Encephalomyelitis	5.2%
358	Charcot-Marie-Tooth Disease	5.1%
359	Myasthenia Gravis, Autoimmune, Experimental	5.1%
360	Coma, Post-Head Injury	5.1%
361	Uveomeningoencephalitic Syndrome	5.1%
362	Sturge-Weber Syndrome	5%
363	Vertigo	5%
364	Alcohol-Induced Disorders, Nervous System	5%
365	Leukoencephalitis, Acute Hemorrhagic	5%
366	Jet Lag Syndrome	5%
367	Sciatic Neuropathy	4.9%
368	Ulnar Neuropathies	4.9%
369	Lesion of Sciatic Nerve	4.9%
370	Ulnar Neuritis	4.9%
371	Radial nerve compression	4.9%
372	Radial Tunnel Syndrome	4.9%
373	Peroneal Neuropathies	4.9%
374	Radial Neuropathy	4.9%
375	Median Neuropathy	4.9%
376	Sciatic Nerve Palsy	4.9%
377	Femoral Neuropathy	4.9%
378	Tibial Neuropathy	4.9%
379	Ulnar Nerve Palsy	4.9%
380	Postural Orthostatic Tachycardia Syndrome	4.9%
381	Radial nerve palsy	4.9%
382	Multiple Sclerosis, Chronic Progressive	4.9%
383	Multiple Sclerosis, Relapsing-Remitting	4.9%
384	Lyme Neuroborreliosis	4.9%
385	Gaucher Disease	4.7%
386	Myotonia Congenita	4.6%
387	Waterhouse-Friderichsen Syndrome	4.6%
388	Cerebrospinal Fluid Otorrhea	4.6%
389	Cerebrospinal Fluid Rhinorrhea	4.6%
390	Neuritis, Autoimmune, Experimental	4.6%
391	Gait Ataxia	4.6%
392	Myositis	4.5%
393	Optic Atrophy	4.5%
394	Optic Neuritis	4.5%
395	Papilledema	4.5%
396	Strabismus	4.5%
397	Tolosa-Hunt Syndrome	4.5%
398	Isaacs syndrome	4.5%
399	Arsenic Poisoning	4.5%
400	Myotonic Disorders	4.5%
401	Myasthenic Syndromes, Congenital	4.5%
402	Vocal Cord Paralysis	4.5%
403	Carpal Tunnel Syndrome	4.5%
404	Tay-Sachs Disease	4.5%
405	neurofibroma	4.5%
406	Diabetic Neuropathies	4.4%
407	Facial Injuries	4.4%
408	Facial Neuralgia	4.4%
409	Diabetic Amyotrophy	4.4%
410	Diabetic Autonomic Neuropathy	4.4%
411	Sleep Talking	4.4%
412	Manganese Poisoning	4.4%
413	Sleep Disorders, Intrinsic	4.4%
414	Orthostatic intolerance	4.4%
415	Sciatica	4.4%
416	Tuberous Sclerosis	4.4%
417	Anosmia	4.4%
418	Ataxia	4.4%
419	Athetosis	4.4%
420	Catalepsy	4.4%
421	Dystonia	4.4%
422	Hemiplegia	4.4%
423	Locked-In Syndrome	4.4%
424	Meningeal Neoplasms	4.4%
425	Meningomyelocele	4.4%
426	Muscle Hypertonia	4.4%
427	Muscle hypotonia	4.4%
428	Myoclonus	4.4%
429	Myotonia	4.4%
430	Neuralgia	4.4%
431	Paraplegia	4.4%
432	Pseudobulbar Palsy	4.4%
433	Quadriplegia	4.4%
434	Spasm	4.4%
435	Spastic Paraplegia	4.4%
436	Status Epilepticus	4.4%
437	Taste Disorders	4.4%
438	Tremor	4.4%
439	Spina Bifida	4.4%
440	Monoplegia	4.4%
441	Hypokinesia	4.4%
442	Paraparesis	4.4%
443	Bradykinesia	4.4%
444	Waxy flexibility	4.4%
445	Action Tremor	4.4%
446	Resting Tremor	4.4%
447	Dysosmia	4.4%
448	Quadriparesis	4.4%
449	Mercury Poisoning, Nervous System	4.4%
450	Olfaction Disorders	4.4%
451	Myokymia	4.4%
452	Lead Poisoning, Nervous System	4.4%
453	Vestibular Neuronitis	4.4%
454	Somatosensory Disorders	4.4%
455	Neuropathic pain	4.4%
456	Hyperkinesia	4.4%
457	Intention tremor	4.4%
458	Voice Disorders	4.2%
459	Voice Disturbance	4.2%
460	Niemann-Pick Disease, Type C	4.1%
461	Polyradiculopathy	4.1%
462	Smith-Magenis syndrome	4.1%
463	Cubital Tunnel Syndrome	4%
464	Dural Arteriovenous Fistula	4%
465	Myotonic Dystrophy	3.9%
466	Akathisia	3.8%
467	Restlessness	3.8%
468	Psychomotor Agitation	3.8%
469	Alcohol Withdrawal Seizures	3.7%
470	Hand-Arm Vibration Syndrome	3.6%
471	Gait Apraxia	3.5%
472	Vision Disorders	3.5%
473	Metamorphopsia	3.5%
474	Visual Impairment	3.5%
475	Fibromyalgia	3.4%
476	Optic Neuropathy, Ischemic	3.4%
477	Anterior Ischemic Optic Neuropathy	3.4%
478	Medial Tibial Stress Syndrome	3.4%
479	Facial Hemiatrophy	3.4%
480	Melkersson-Rosenthal Syndrome	3.4%
481	Mitochondrial Myopathies	3.4%
482	Thoracic Outlet Syndrome	3.4%
483	Anisocoria	3.4%
484	Confusion	3.4%
485	Facial paralysis	3.4%
486	Lethargy	3.4%
487	Memory Disorders	3.4%
488	Muscle Cramp	3.4%
489	Perceptual Disorders	3.4%
490	Psychomotor Disorders	3.4%
491	Tonic Pupil	3.4%
492	Eosinophilia-Myalgia Syndrome	3.4%
493	Anhedonia	3.4%
494	Disorientation	3.4%
495	Facial Paresis	3.4%
496	Memory Loss	3.4%
497	Hemisensory Neglect	3.4%
498	Dysacusis	3.4%
499	Optic Nerve Glioma	3.4%
500	Sleep Bruxism	3.3%
501	Reflex, Abnormal	3.3%
502	Hyporeflexia	3.3%
503	Hyperreflexia	3.3%
504	Anencephaly	3.3%
505	Meningocele	3.3%
506	Muscular Atrophy	3.3%
507	Respiratory Paralysis	3.3%
508	Encephalocele	3.3%
509	Esotropia	3.3%
510	Exotropia	3.3%
511	Hypotension, Orthostatic	3.3%
512	Sleep Apnea Syndromes	3.3%
513	Polymyositis	3.3%
514	Post-Exercise Hypotension	3.3%
515	Tetany	3.3%
516	Disorders of Excessive Somnolence	3.3%
517	Sleep Initiation and Maintenance Disorders	3.3%
518	Night Terrors	3.3%
519	Somnambulism	3.3%
520	Trigeminal Nerve Disorder	3.3%
521	Transient Insomnia	3.3%
522	Sleep Paralysis	3.3%
523	Chronic Insomnia	3.3%
524	REM Sleep Behavior Disorder	3.3%
525	Hypersomnia	3.3%
526	Dermal Sinus	3.2%
527	Dysgeusia	3.2%
528	Formication	3.2%
529	Hyperalgesia	3.2%
530	Hyperesthesia	3.2%
531	Hypesthesia	3.2%
532	Language Disorders	3.2%
533	Numbness	3.2%
534	Paresthesia	3.2%
535	Paraparesis, Spastic	3.2%
536	Spina Bifida Cystica	3.2%
537	Trismus	3.2%
538	Spina Bifida Occulta	3.2%
539	Epilepsia Partialis Continua	3.2%
540	Hypogeusia	3.2%
541	Meningeal Carcinomatosis	3.2%
542	Brown-Sequard Syndrome	3.2%
543	Lissencephaly	3.2%
544	Polymicrogyria	3.2%
545	Pachygyria	3.2%
546	Schizencephaly	3.2%
547	Lockjaw	3.2%
548	Allodynia	3.2%
549	Lead Poisoning, Nervous System, Childhood	3.2%
550	Lead Poisoning, Nervous System, Adult	3.2%
551	Periventricular Nodular Heterotopia	3.2%
552	Ageusia	3.2%
553	Alstrom Syndrome	3.1%
554	Classical Lissencephalies and Subcortical Band Heterotopias	2.9%
555	Amyloid Neuropathies, Familial	2.8%
556	Duane Retraction Syndrome	2.7%
557	Consciousness Disorders	2.7%
558	Mental Retardation	2.7%
559	Muscle Weakness	2.7%
560	Depressed Level of Consciousness	2.7%
561	Mental deficiency	2.7%
562	Intellectual Disability	2.7%
563	Mobius Syndrome	2.7%
564	Bell Palsy	2.7%
565	Sleep Apnea, Obstructive	2.7%
566	Sleep Apnea, Central	2.7%
567	Narcolepsy	2.7%
568	Trigeminal Neuralgia	2.7%
569	Kleine-Levin Syndrome	2.7%
570	Catatonia	2.7%
571	Agraphia	2.7%
572	Alexia	2.7%
573	Anomia	2.7%
574	Cluttering	2.7%
575	Language Development Disorders	2.7%
576	Speech Disorders	2.7%
577	Syncope	2.7%
578	Stupor	2.7%
579	Dysgraphia	2.7%
580	Dyslexia	2.7%
581	Presyncope	2.7%
582	Dyslalia	2.7%
583	Herpes Zoster Oticus	2.7%
584	Familial Periodic Paralysis	2.7%
585	Aphonia	2.6%
586	Sleep Deprivation	2.6%
587	Dysphonia	2.6%
588	Acoustic Neuroma	2.6%
589	Eye Injuries	2.6%
590	Neurofibrosarcoma	2.5%
591	Muscular Dystrophy	2.5%
592	Congenital nystagmus	2.5%
593	Orbital Myositis	2.5%
594	Diplopia	2.5%
595	Muscle Rigidity	2.5%
596	Muscle Spasticity	2.5%
597	Scotoma	2.5%
598	Photophobia	2.5%
599	Cogwheel Rigidity	2.5%
600	Hemifacial Spasm	2.5%
601	Amaurosis	2.5%
602	Blindness	2.5%
603	Nuchal Rigidity	2.5%
604	Pyomyositis	2.5%
605	Agnosia	2.4%
606	Apraxias	2.4%
607	Hallucinations	2.4%
608	Hemianopsia	2.4%
609	Hyperacusis	2.4%
610	Tinnitus	2.4%
611	Visual Agnosia	2.4%
612	Anosognosia	2.4%
613	Wernicke-Korsakoff Syndrome	2.4%
614	Phonophobia	2.4%
615	Hearing Loss	2.4%
616	Sarcopenia	2.4%
617	Cataplexy	2.4%
618	Aphasia	2.4%
619	Articulation Disorders	2.4%
620	Echolalia	2.4%
621	Stuttering	2.4%
622	Dysphasia	2.4%
623	Dysarthria	2.3%
624	Optic Atrophy, Hereditary, Leber	2.2%
625	Myalgia	2.2%
626	Kearns-Sayre syndrome	2.2%
627	Neuronal Ceroid-Lipofuscinoses	2.2%
628	Eye Burns	2.1%
629	Welander Distal Myopathy	2%
630	Amaurosis Fugax	2%
631	Blindness, Cortical	2%
632	Dyscalculia	2%
633	Rett Syndrome	2%
634	Deafness	2%
635	Hearing Loss, Sudden	2%
636	Gerstmann Syndrome	2%
637	Hearing Loss, Bilateral	2%
638	Hearing Loss, High-Frequency	2%
639	Hearing Loss, Mixed Conductive-Sensorineural	2%
640	Prosopagnosia	2%
641	Apraxia, Ideomotor	2%
642	Charles Bonnet Syndrome	2%
643	Hearing Loss, Unilateral	2%
644	Complete Hearing Loss	2%
645	Alien Hand Syndrome	2%
646	Deaf Mutism	2%
647	Amnesia	2%
648	Delirium	2%
649	Dissociative Amnesia	2%
650	Color blindness	2%
651	Global Amnesia	2%
652	Cri-du-Chat Syndrome	2%
653	Down Syndrome	2%
654	Trisomy 21	2%
655	POEMS Syndrome	2%
656	Meningioma	2%
657	Williams Syndrome	2%
658	Microcephaly	2%
659	Macrocephaly	2%
660	Hypokalemic periodic paralysis	1.9%
661	Porencephaly	1.9%
662	Aicardi's syndrome	1.9%
663	Hoarseness	1.9%
664	Cockayne Syndrome	1.9%
665	Alcohol Withdrawal Delirium	1.9%
666	Mutism	1.8%
667	Selective Mutism	1.8%
668	Alexia, Pure	1.7%
669	Dermatomyositis	1.7%
670	Corneal Scar	1.7%
671	Holoprosencephaly	1.7%
672	Prader-Willi Syndrome	1.6%
673	Muscular Dystrophy, Duchenne	1.6%
674	Phantom pain	1.6%
675	Phantom Limb Pain	1.6%
676	Retrograde amnesia	1.6%
677	Amnesia, Anterograde	1.6%
678	Corneal Perforation	1.5%
679	Fragile X Syndrome	1.3%
680	Rubinstein-Taybi Syndrome	1.2%
681	Mucopolysaccharidosis II	0.9%

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