MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Glycogen storage disease type II

(UMLS:C0017921)

Definition:: An autosomal recessively inherited glycogen storage disease caused by GLUCAN 1,4-ALPHA-GLUCOSIDASE deficiency. Large amounts of GLYCOGEN accumulate in the LYSOSOMES of skeletal muscle (MUSCLE, SKELETAL); HEART; LIVER; SPINAL CORD; and BRAIN. Three forms have been described: infantile, childhood, and adult. The infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy (CARDIOMYOPATHY, HYPERTROPHIC). The childhood form usually presents in the second year of life with proximal weakness and respiratory symptoms. The adult form consists of a slowly progressive proximal myopathy. (From Muscle Nerve 1995;3:S61-9; Menkes, Textbook of Child Neurology, 5th ed, pp73-4)
UMLS ID:: C0017921
MeSH ID:: D006009

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.435.340

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189.435.340|C16.320.565.202.449.500|C16.320.565.595.554.340

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.435.340|C18.452.648.189.435.340|C18.452.648.202.449.500|C18.452.648.595.554.340

Synonym(s)

Glycogen storage disease type II

2 glycogenosis

ALPHA GLUCOSIDASE DEFICIENCY

ALPHA-GLUCOSIDASE DEFICIENCY

AMD - Acid maltase deficiency

Acid maltase deficiency

Deficiency of acid maltase

Deficiency of alpha-glucosidase

Deficiency of amyloglucosidase

10.

Deficiency of exo-1,4-alpha-glucosidase

11.

Deficiency of gamma-amylase

12.

Deficiency of glucan 1,4-alpha-glucosidase

13.

Deficiency of glucoamylase

14.

Deficiency of glucoinvertase

15.

Deficiency of glucosidosucrase

16.

Deficiency of maltase

17.

GENERALIZED GLYCOGENOSIS

18.

GLYCOGEN STORAGE DISEASE II

19.

GLYCOGENOSIS, TYPE II

20.

GSD type II

21.

Generalized glycogenosis

22.

Glycogen Storage Disease Type II

23.

Glycogen storage disease, type II

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Simvastatin	FAERS: 2		US FAERS
2	Venlafaxine Hydrochloride	FAERS: 2		US FAERS
3	Glycogen		18176891	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Galactosemias	55.2%
2	Leigh Disease	51.5%
3	Urea Cycle Disorders, Inborn	49.7%
4	Tyrosinemias	49.7%
5	Adrenoleukodystrophy	47.2%
6	Gaucher Disease	44.4%
7	Hepatolenticular Degeneration	44%
8	Menkes Kinky Hair Syndrome	43.8%
9	Fabry Disease	42.3%
10	Homocystinuria	41.8%
11	Refsum Disease	40.5%
12	Zellweger Syndrome	40.5%
13	Carbamoyl-Phosphate Synthase I Deficiency Disease	37.2%
14	Smith-Lemli-Opitz Syndrome	36.7%
15	Amino Acid Metabolism, Inborn Errors	36%
16	Metal Metabolism, Inborn Errors	36%
17	Progeria	36%
18	Peroxisomal Disorders	36%
19	Niemann-Pick Disease, Type C	34.7%
20	Tay-Sachs Disease	32.9%
21	Hyperphosphaturia	32.6%
22	Lactose Intolerance	32.4%
23	MELAS Syndrome	31.6%
24	Pseudohypoparathyroidism	31.5%
25	Mucopolysaccharidosis III	29.8%
26	Mucopolysaccharidosis II	29.8%
27	Glycogen Storage Disease Type I	29.5%
28	Glycogen Storage Disease Type V	29.5%
29	Cystinosis	29.1%
30	Brain Diseases, Metabolic, Inborn	26.8%
31	Hyperhomocysteinemia	26.7%
32	Canavan Disease	26.6%
33	Alexander Disease	26.6%
34	Cytochrome-c Oxidase Deficiency	26.4%
35	Amyloid Neuropathies, Familial	25.1%
36	Carbohydrate Metabolism, Inborn Errors	24.8%
37	Lysosomal Storage Diseases	24.8%
38	Hypolipoproteinemias	24.8%
39	Albinism	24.3%
40	Ichthyosis, X-Linked	23.6%
41	Wasting Syndrome	23.4%
42	Hyperlipidemia, Familial Combined	23%
43	Werner Syndrome	22.7%
44	Hyperlipoproteinemia Type IV	22.6%
45	Hyperlipoproteinemia Type V	22.6%
46	Familial Hypophosphatemic Rickets	22.2%
47	Hyperlipoproteinemia Type III	22.1%
48	Neuronal Ceroid-Lipofuscinoses	21.6%
49	Alkaptonuria	21.5%
50	Hypophosphatasia	21.5%
51	Propionic acidemia	21.5%
52	Dihydropyrimidine Dehydrogenase Deficiency	21.5%
53	Renal tubular acidosis	21%
54	Glycogen storage disease type II	20.2%
55	Cockayne Syndrome	19.6%
56	Acid-Base Imbalance	19.3%
57	Calcium Metabolism Disorders	19.3%
58	Iron Metabolism Disorders	19.3%
59	Phosphorus Metabolism Disorders	19.3%
60	Water-Electrolyte Imbalance	19.3%
61	Lipid Metabolism Disorders	19.3%
62	Mitochondrial Diseases	19.3%
63	Glucose Metabolism Disorders	19.3%
64	Mitochondrial Encephalomyopathies	19.2%
65	Hypercalcemia	19.2%
66	Hypocalcemia	19.2%
67	Milk-Alkali Syndrome	19.2%
68	Familial Periodic Paralysis	18.7%
69	Myelinolysis, Central Pontine	18.5%
70	Sjogren-Larsson Syndrome	18.4%
71	Glycosuria, Renal	18.2%
72	Renal Aminoacidurias	17.9%
73	Fanconi Syndrome	17.9%
74	Pseudohypoaldosteronism	17.9%
75	Liddle Syndrome	17.9%
76	Antley-Bixler Syndrome Phenotype	17.7%
77	Lipodystrophy	17.5%
78	Osteopenia	17.5%
79	Ataxia Telangiectasia	17.1%
80	Reye Syndrome	17.1%
81	Hepatic Encephalopathy	17.1%
82	Rickets	16.8%
83	Gout	16.8%
84	Hypoalphalipoproteinemias	16.4%
85	Kernicterus	15.4%
86	Aicardi's syndrome	15.2%
87	Wernicke Encephalopathy	15.1%
88	Cystic Fibrosis	14.8%
89	Glycogen Storage Disease	14.8%
90	Porphyrias, Hepatic	14.2%
91	CHARGE Syndrome	14.1%
92	Fanconi Anemia	14%
93	Myasthenic Syndromes, Congenital	13.8%
94	Congenital Hyperinsulinism	13.4%
95	Neoplastic Syndromes, Hereditary	13.3%
96	Friedreich Ataxia	13.2%
97	Brain Diseases, Metabolic	13.1%
98	Multiple Epiphyseal Dysplasia	13.1%
99	Osteochondrodysplasias	13.1%
100	Pelger-Huet Anomaly	13.1%
101	Nail-Patella Syndrome	13%
102	Optic Atrophy, Hereditary, Leber	12.6%
103	Nutrition Disorders	12.3%
104	Hypokalemic periodic paralysis	12.3%
105	Xeroderma Pigmentosum	12.2%
106	Muscular Dystrophy	12.2%
107	Muscular Dystrophy, Duchenne	12.2%
108	Dwarfism	12.1%
109	Anemia, Sickle Cell	12%
110	Thalassemia	12%
111	Bloom Syndrome	12%
112	Cystinuria	11.9%
113	Osteogenesis Imperfecta	11.9%
114	Alstrom Syndrome	11.9%
115	Kartagener Syndrome	11.8%
116	Marfan Syndrome	11.4%
117	Smith-Magenis syndrome	11.3%
118	Fragile X Syndrome	11.2%
119	Prader-Willi Syndrome	11.1%
120	Arthritis, Gouty	11%
121	Autoimmune Lymphoproliferative Syndrome	11%
122	Beckwith-Wiedemann Syndrome	11%
123	Wolf-Hirschhorn Syndrome	11%
124	Angioedemas, Hereditary	10.9%
125	Tuberous Sclerosis	10.8%
126	Acidosis	10.6%
127	Alkalosis	10.6%
128	Amyloidosis	10.6%
129	Calcinosis	10.6%
130	Hyperglycemia	10.6%
131	Hyperinsulinism	10.6%
132	Hyperkalemia	10.6%
133	Hypernatremia	10.6%
134	Hypoglycemia	10.6%
135	Hypokalemia	10.6%
136	Hyponatremia	10.6%
137	Xanthomatosis	10.6%
138	Hypophosphatemia	10.6%
139	Metabolic acidosis	10.6%
140	Dyslipidemias	10.6%
141	Iron Overload	10.6%
142	Xanthoma	10.6%
143	Myotonic Dystrophy	10.6%
144	Holoprosencephaly	10.5%
145	Cri-du-Chat Syndrome	10.4%
146	Down Syndrome	10.4%
147	Trisomy 21	10.4%
148	Wiskott-Aldrich Syndrome	10.4%
149	Osteomalacia	10.2%
150	Kallmann Syndrome	10%
151	Dystonia Musculorum Deformans	10%
152	HIV Wasting Syndrome	9.9%
153	Diabetes Mellitus	9.8%
154	Dehydration	9.7%
155	Lipomatosis	9.7%
156	Water Intoxication	9.7%
157	Achlorhydria	9.6%
158	Osteoporosis	9.6%
159	Bone Demineralization, Pathologic	9.6%
160	Post-Traumatic Osteoporosis	9.6%
161	Celiac Disease	9.6%
162	Sprue, Tropical	9.6%
163	Steatorrhea	9.6%
164	Sprue	9.6%
165	Huntington Disease	9.6%
166	Mitochondrial Myopathies	9.5%
167	Ectodermal Dysplasia	9.3%
168	Aplasia Cutis Congenita	9.3%
169	Rubinstein-Taybi Syndrome	9.3%
170	Deformity	9.2%
171	Glycosuria	8.7%
172	Diabetic Ketoacidosis	8.7%
173	Nesidioblastosis	8.4%
174	Variegate Porphyria	8.4%
175	Acute intermittent porphyria	8.4%
176	Porphyria Cutanea Tarda	8.4%
177	Fetal Diseases	8.4%
178	Williams Syndrome	8.3%
179	HIV-Associated Lipodystrophy Syndrome	8.2%
180	Renal Osteodystrophy	8.2%
181	Renal rickets	8.2%
182	Necrobiosis Lipoidica Diabeticorum	8%
183	Rett Syndrome	8%
184	Polycystic Kidney Diseases	8%
185	Lafora Disease	8%
186	Unverricht-Lundborg Syndrome	8%
187	Familial Mediterranean Fever	8%
188	Dandy-Walker Syndrome	7.9%
189	Kearns-Sayre syndrome	7.9%
190	Amyotrophic Lateral Sclerosis	7.8%
191	Retinal Dysplasia	7.6%
192	Aniridia	7.5%
193	Primary Ciliary Dyskinesia	7.5%
194	Epidermolysis Bullosa	7.5%
195	Marchiafava-Bignami Disease	7.4%
196	Sickle Cell Trait	7.2%
197	Myotonia Congenita	7%
198	Meningoencephalitis	6.9%
199	Meconium Aspiration Syndrome	6.8%
200	Welander Distal Myopathy	6.7%
201	Duane Retraction Syndrome	6.7%
202	Leukomalacia, Periventricular	6.7%
203	Cutis Laxa	6.6%
204	Retinitis Pigmentosa	6.6%
205	Pigmentary retinopathy	6.6%
206	Porokeratosis	6.6%
207	Keratoderma, Palmoplantar	6.6%
208	Chronic granulomatous disease	6.6%
209	Pseudoxanthoma Elasticum	6.5%
210	Child Nutrition Disorders	6.4%
211	Hypervitaminosis A	6.4%
212	Infant Nutrition Disorders	6.4%
213	Malnutrition	6.4%
214	Acidosis, Lactic	6.4%
215	Calciphylaxis	6.4%
216	Hemosiderosis	6.4%
217	Ketosis	6.4%
218	Ketonuria	6.4%
219	Ketoacidosis	6.4%
220	Ketonemia	6.4%
221	Vascular calcification	6.4%
222	Dementia, Vascular	6.3%
223	Encephalomyelitis	6.3%
224	Mobius Syndrome	6.3%
225	Acute Chest Syndrome	6.2%
226	Subdural Effusion	6.2%
227	Cerebral Amyloid Angiopathy	6.2%
228	Pneumocephalus	6.1%
229	Brain Abscess	6.1%
230	Peutz-Jeghers Syndrome	6%
231	Thrombasthenia	6%
232	Antithrombin III Deficiency	6%
233	Protein C Deficiency	6%
234	Afibrinogenemia	6%
235	Factor VII Deficiency	6%
236	Factor X Deficiency	6%
237	Factor XII Deficiency	6%
238	Hemophilia A	6%
239	Activated Protein C Resistance	6%
240	Factor II deficiency	6%
241	Factor VIII Deficiency	6%
242	Factor V deficiency	6%
243	Factor XI Deficiency	6%
244	Hypoprothrombinemias	6%
245	Anemia, Diamond-Blackfan	6%
246	Multiple System Atrophy	5.9%
247	Tetany	5.9%
248	Acidosis, Respiratory	5.7%
249	Adiposis Dolorosa	5.7%
250	Alkalosis, Respiratory	5.7%
251	Insulin Resistance	5.7%
252	Osteoporosis, Postmenopausal	5.7%
253	Basal Cell Nevus Syndrome	5.7%
254	Multiple Endocrine Neoplasia	5.7%
255	Xeroderma	5.7%
256	Congenital Hypothyroidism	5.6%
257	Dermatitis, Atopic	5.6%
258	Akinetic Mutism	5.6%
259	Anoxic Encephalopathy	5.6%
260	Basal Ganglia Diseases	5.6%
261	Brain Damage, Chronic	5.6%
262	Cerebellar Diseases	5.6%
263	Encephalitis	5.6%
264	Encephalomalacia	5.6%
265	Epilepsy	5.6%
266	Hydrocephalus	5.6%
267	Congenital Hydrocephalus	5.6%
268	Hypothalamic Diseases	5.6%
269	Thalamic Diseases	5.6%
270	Intracranial Hypertension	5.6%
271	Aura	5.6%
272	Leukoencephalopathy	5.6%
273	Neuroaxonal Dystrophies	5.6%
274	Headache Disorders	5.6%
275	Intracranial Hypotension	5.6%
276	Brain Edema	5.6%
277	Brain Hypoxia	5.6%
278	Aqueductal Stenosis	5.6%
279	Charcot-Marie-Tooth Disease	5.5%
280	Lewy Body Disease	5.4%
281	Gestational Diabetes	5.3%
282	Latent Autoimmune Diabetes in Adults	5.3%
283	Diabetes Mellitus, Experimental	5.3%
284	Brain Injuries	5.3%
285	Brain Neoplasms	5.2%
286	Nephrocalcinosis	5.2%
287	Behcet Syndrome	5.2%
288	Ocular Motility Disorders	5.1%
289	Cyclophoria	5.1%
290	Basal Ganglia Cerebrovascular Disease	5.1%
291	Cerebrovascular Disorders	5.1%
292	Cerebrovascular Insufficiency	5.1%
293	Dementia	5.1%
294	Classical Lissencephalies and Subcortical Band Heterotopias	5.1%
295	Epilepsy, Post-Traumatic	5%
296	Parkinsonian Disorders	4.9%
297	Frontotemporal dementia	4.9%
298	Primary amyloidosis	4.8%
299	Abdominal Cramps	4.8%
300	Abnormalities, Drug-Induced	4.8%
301	Amniotic Band Syndrome	4.8%
302	Asphyxia Neonatorum	4.8%
303	Infant, Premature, Diseases	4.8%
304	Situs Inversus	4.8%
305	Infantile Colic	4.8%
306	Hyperkeratosis, Epidermolytic	4.8%
307	Polycystic Kidney, Autosomal Dominant	4.8%
308	Brain Death	4.7%
309	Epidural Abscess	4.6%
310	Toxoplasmosis, Congenital	4.6%
311	Amblyopia	4.6%
312	Meningitis	4.5%
313	Movement Disorders	4.5%
314	Pachymeningitis	4.5%
315	Spinal Cord Diseases	4.5%
316	Nephroblastoma	4.5%
317	Posterior Leukoencephalopathy Syndrome	4.4%
318	Posterior reversible encephalopathy syndrome	4.4%
319	Eye Abnormalities	4.4%
320	Cardiovascular Abnormalities	4.4%
321	Subacute Combined Degeneration	4.4%
322	Skin Abnormalities	4.4%
323	Lymphatic Abnormalities	4.4%
324	Congenital Microtia	4.4%
325	Dural Arteriovenous Fistula	4.4%
326	Anemia, Neonatal	4.4%
327	Persistent Fetal Circulation Syndrome	4.4%
328	Progressive supranuclear palsy	4.3%
329	Congenital diaphragmatic hernia	4.3%
330	Umbilical hernia	4.3%
331	Myelitis	4.3%
332	Congenital nystagmus	4.3%
333	Adenomatous Polyposis Coli	4.2%
334	Hypercholesterolemia	4.2%
335	Hyperlipoproteinemias	4.2%
336	Hypertriglyceridemia	4.2%
337	Central Nervous System Infection	4.2%
338	Anencephaly	4.2%
339	Stiff-Person Syndrome	4.1%
340	CREST Syndrome	4.1%
341	Urogenital Abnormalities	4.1%
342	Vascular Headaches	4.1%
343	Amnesia, Transient Global	4.1%
344	Hypoxia-Ischemia, Brain	4%
345	Leukoencephalopathy, Progressive Multifocal	4%
346	Neonatal Abstinence Syndrome	4%
347	Meige Syndrome	4%
348	Cerebral Ventriculitis	4%
349	Fetal Growth Retardation	4%
350	Fetal Hypoxia	4%
351	Fetal Alcohol Spectrum Disorders	4%
352	Syphilis, Congenital	3.9%
353	Papillon-Lefevre Disease	3.9%
354	Cerebellar Neoplasms	3.9%
355	Parkinson Disease	3.9%
356	Neuroleptic Malignant Syndrome	3.8%
357	Lupus Vasculitis, Central Nervous System	3.8%
358	Hydranencephaly	3.8%
359	Neural Tube Defects	3.8%
360	Tethered Cord Syndrome	3.8%
361	Iniencephaly	3.8%
362	Craniorachischisis	3.8%
363	Exencephaly	3.8%
364	Septo-Optic Dysplasia	3.8%
365	Cortical Dysplasia	3.8%
366	Malformations of Cortical Development	3.8%
367	Central Nervous System Cysts	3.8%
368	Limbic Encephalitis	3.6%
369	Chorioamnionitis	3.6%
370	Creutzfeldt-Jakob disease	3.6%
371	Hydrops Fetalis	3.6%
372	Prion Diseases	3.5%
373	Deficiency Diseases	3.5%
374	Starvation	3.5%
375	Refeeding Syndrome	3.5%
376	Turner Syndrome	3.4%
377	Abnormalities, Radiation-Induced	3.4%
378	Multiple Endocrine Neoplasia Type 1	3.3%
379	Myoclonic Epilepsy	3.3%
380	Epilepsy, Temporal Lobe	3.3%
381	Epilepsy, Rolandic	3.3%
382	Benign Rolandic Epilepsy	3.3%
383	Striatonigral Degeneration	3.3%
384	Spinal Cord Injuries	3.3%
385	Spinal Muscular Atrophy	3.3%
386	Progressive Muscular Atrophy	3.3%
387	Vasculitis, Central Nervous System	3.2%
388	Asterixis	3.2%
389	Ballismus	3.2%
390	Maxillofacial Abnormalities	3.2%
391	Dextrocardia	3.2%
392	Presenile dementia	3.2%
393	Senile dementia	3.2%
394	Klinefelter Syndrome	3.2%
395	Basal Ganglia Hemorrhage	3.2%
396	Toxoplasmosis, Cerebral	3.2%
397	Leukoencephalitis, Acute Hemorrhagic	3.2%
398	Poliomyelitis	3.1%
399	Brain Hemorrhage, Traumatic	3.1%
400	Ophthalmoplegic Migraine	3.1%
401	Ophthalmia Neonatorum	3.1%
402	Cerebral Palsy	3.1%
403	Epilepsies, Partial	3.1%
404	Epilepsy, Generalized	3.1%
405	Pseudotumor Cerebri	3.1%
406	Hypertensive Encephalopathy	3.1%
407	Simple Partial Seizures	3.1%
408	Epilepsy, Reflex	3.1%
409	Headache Disorders, Primary	3.1%
410	Headache Disorders, Secondary	3.1%
411	Medication overuse headache	3.1%
412	Shy-Drager Syndrome	3.1%
413	Miller Fisher Syndrome	3.1%
414	Meningitis, Bacterial	3.1%
415	Meningitis, Fungal	3.1%
416	Chronic Fatigue Syndrome	3%
417	Cranial nerve diseases	3%
418	Demyelinating Diseases	3%
419	Demyelination	3%
420	Neuromuscular Diseases	3%
421	Chronobiology Disorders	3%
422	Restless Legs Syndrome	3%
423	Paraneoplastic Cerebellar Degeneration	2.9%
424	Pituitary Adenoma	2.9%
425	Pituitary Neoplasms	2.9%
426	Carotid Artery Injuries	2.9%
427	Brain Injuries, Diffuse	2.9%
428	Traumatic Brain Injury	2.9%
429	Cerebellar Ataxia	2.9%
430	Supratentorial Neoplasms	2.9%
431	Myelitis, Transverse	2.9%
432	Pituitary Diseases	2.8%
433	Scimitar Syndrome	2.8%
434	Pituitary Apoplexy	2.8%
435	Carotid Artery Diseases	2.8%
436	Brain Ischemia	2.8%
437	Cerebrovascular accident	2.8%
438	Kluver-Bucy Syndrome	2.8%
439	Vasospasm, Intracranial	2.8%
440	Intracranial Arterial Diseases	2.8%
441	Brain Infarction	2.8%
442	Motor Neuron Disease	2.8%
443	Akathisia, Drug-Induced	2.8%
444	Trauma, Nervous System	2.7%
445	Persistent Vegetative State	2.7%
446	Nervous System Neoplasms	2.7%
447	Neurologic Manifestations	2.7%
448	Neurotoxicity Syndromes	2.7%
449	Opsoclonus-Myoclonus Syndrome	2.7%
450	MPTP Poisoning	2.7%
451	Prune Belly Syndrome	2.7%
452	Twins, Conjoined	2.7%
453	Waardenburg Syndrome	2.7%
454	Obesity	2.7%
455	Polyradiculoneuropathy	2.6%
456	Polyradiculoneuritis	2.6%
457	Denys-Drash Syndrome	2.6%
458	Spinal Cord Neoplasms	2.6%
459	Encephalomyelitis, Acute Disseminated	2.6%
460	Intracranial Embolism and Thrombosis	2.5%
461	Sleep Wake Disorders	2.5%
462	Anophthalmos	2.4%
463	Anus, Imperforate	2.4%
464	Microphthalmos	2.4%
465	Paralysis, Obstetric	2.4%
466	Retinopathy of Prematurity	2.4%
467	Limb Deformities, Congenital	2.4%
468	Craniofacial Abnormalities	2.4%
469	Anorectal Malformations	2.4%
470	Bronchopulmonary Dysplasia	2.4%
471	Arachnoiditis	2.4%
472	Aseptic Meningitis	2.4%
473	Syringomyelia	2.4%
474	Essential Tremor	2.4%
475	Familial Tremor	2.4%
476	Pneumorrhachis	2.4%
477	Writer's Cramp	2.4%
478	Dyskinesia, Drug-Induced	2.4%
479	POEMS Syndrome	2.3%
480	Microcephaly	2.3%
481	Macrocephaly	2.3%
482	Auditory Perceptual Disorders	2.3%
483	Craniosynostosis	2.2%
484	Syndactyly	2.2%
485	Brachycephaly	2.2%
486	Blepharophimosis	2.2%
487	Laryngostenosis	2.2%
488	Mouth Abnormalities	2.2%
489	Respiratory Distress Syndrome, Newborn	2.2%
490	Juvenile Myoclonic Epilepsy	2.2%
491	Myoclonic Epilepsies, Progressive	2.2%
492	Esophageal Atresia	2.2%
493	Intestinal Atresia	2.2%
494	Horseshoe Kidney	2.2%
495	Pectus excavatum	2.2%
496	Klippel-Feil Syndrome	2.2%
497	Gastroschisis	2.2%
498	Synostosis	2.2%
499	Acrodermatitis	2.2%
500	Lymphangiectasis, Intestinal	2.2%
501	Gianotti-Crosti Syndrome	2.2%
502	Central Nervous System Fungal Infections	2.2%
503	Conus Medullaris Syndrome	2.2%
504	Spinal Cord Vascular Diseases	2.2%
505	Putaminal Hemorrhage	2.2%
506	AIDS Dementia Complex	2.2%
507	Meningomyelocele	2.2%
508	Spina Bifida	2.2%
509	Moyamoya Disease	2.1%
510	Acrocephalosyndactylia	2.1%
511	Kwashiorkor	2.1%
512	Magnesium Deficiency	2.1%
513	Potassium Deficiency	2.1%
514	Protein Deficiency	2.1%
515	Avitaminosis	2.1%
516	Autonomic Dysreflexia	2.1%
517	Complex Regional Pain Syndromes	2.1%
518	Noonan Syndrome	2.1%
519	Arthrogryposis	2%
520	Choanal Atresia	2%
521	Tracheobronchomegaly	2%
522	Laryngocele	2%
523	Choledochal Cyst	2%
524	Hermaphroditism	2%
525	Disorders of Sex Development	2%
526	Lambert-Eaton Myasthenic Syndrome	2%
527	Cryptorchidism	2%
528	Hypospadias	2%
529	Tuberculosis, Meningeal	2%
530	Central Nervous System Bacterial Infections	2%
531	Infarction, Middle Cerebral Artery	2%
532	Infarction, Anterior Cerebral Artery	2%
533	Infarction, Posterior Cerebral Artery	2%
534	Meningocele	2%
535	Encephalocele	2%
536	Porencephaly	1.9%
537	Peripheral Nerve Injuries	1.9%
538	Myasthenia Gravis	1.9%
539	Laryngomalacia	1.9%
540	Pectus carinatum	1.9%
541	Bladder Exstrophy	1.9%
542	Epispadias	1.9%
543	Multicystic Dysplastic Kidney	1.9%
544	Guillain-Barre Syndrome	1.9%
545	Post-Traumatic Headache	1.9%
546	Tension Headache	1.9%
547	Epilepsy, Complex Partial	1.9%
548	Migraine Disorders	1.9%
549	Abdominal Migraine	1.9%
550	Status Migrainosus	1.9%
551	Cervicogenic Headache	1.9%
552	Vertebral Artery Dissection	1.8%
553	Cerebral Infarction	1.8%
554	Brain Stem Infarctions	1.8%
555	Cleft Palate	1.8%
556	Sleep Disorders, Circadian Rhythm	1.8%
557	Scrapie	1.8%
558	Central Cord Syndrome	1.8%
559	Botulism	1.8%
560	Subarachnoid Hemorrhage, Traumatic	1.7%
561	Carotid Artery, Internal, Dissection	1.7%
562	Chorea	1.7%
563	Jaw Abnormalities	1.7%
564	Diffuse Axonal Injury	1.7%
565	Brain Stem Neoplasms	1.7%
566	Obesity, Abdominal	1.7%
567	Subacute Sclerosing Panencephalitis	1.7%
568	Empty Sella Syndrome	1.7%
569	Hyperpituitarism	1.7%
570	Hypopituitarism	1.7%
571	Hypophysitis	1.7%
572	Cerebral Arterial Diseases	1.7%
573	Vertebrobasilar Insufficiency	1.7%
574	Basilar Artery Stenosis	1.7%
575	Vertebral Artery Stenosis	1.7%
576	Intracranial Hemorrhage, Hypertensive	1.7%
577	Transient Cerebral Ischemia	1.7%
578	Neuromyelitis Optica	1.7%
579	Brain Concussion	1.7%
580	Giant Cell Arteritis	1.6%
581	Temporal Arteritis	1.6%
582	Meningitis, Cryptococcal	1.6%
583	Meningitis, Listeria	1.6%
584	Brain Contusion	1.6%
585	Meningitis, Haemophilus	1.6%
586	Meningitis, Pneumococcal	1.6%
587	Pediatric Obesity	1.6%
588	Olfactory Nerve Injuries	1.5%
589	Carotid Stenosis	1.5%
590	Intracranial Aneurysm	1.5%
591	Intracranial Arteriosclerosis	1.5%
592	Cerebral Atherosclerosis	1.5%
593	Subarachnoid Hemorrhage	1.5%
594	Cerebral Arteriosclerosis	1.5%
595	Cerebral Hemorrhage	1.5%
596	Dysautonomia	1.5%
597	Vagus Nerve Disorder	1.5%
598	Glossopharyngeal Neuralgia	1.5%
599	Abducens Nerve Diseases	1.5%
600	Heavy Metal Poisoning, Nervous System	1.5%
601	Neuromuscular Junction Diseases	1.5%
602	Tauopathies	1.5%
603	Trochlear Nerve Diseases	1.5%
604	Peripheral Nervous System Diseases	1.5%
605	Cerebral Thrombosis	1.5%
606	Intracranial Embolism	1.5%
607	Intracranial Thrombosis	1.5%
608	Horner Syndrome	1.5%
609	Poland Syndrome	1.5%
610	Torticollis	1.4%
611	Progressive bulbar palsy	1.4%
612	Bulbar palsy	1.4%
613	Amelia	1.4%
614	Arachnodactyly	1.4%
615	Ectopia Cordis	1.4%
616	Ectromelia	1.4%
617	Hemimelia	1.4%
618	Phocomelia	1.4%
619	Sirenomelia	1.4%
620	Polydactyly	1.4%
621	Brachydactyly	1.4%
622	Plagiocephaly	1.4%
623	Lower Extremity Deformities, Congenital	1.4%
624	Upper Extremity Deformities, Congenital	1.4%
625	Single umbilical artery	1.4%
626	Facial Nerve Injuries	1.4%
627	Ascorbic Acid Deficiency	1.4%
628	Vitamin A Deficiency	1.4%
629	Vitamin D Deficiency	1.4%
630	Vitamin E Deficiency	1.4%
631	Marasmus	1.4%
632	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.4%
633	Myopathy	1.4%
634	Optic Neuropathy	1.4%
635	Carotid Artery Thrombosis	1.4%
636	Lateral Medullary Syndrome	1.4%
637	Causalgia	1.4%
638	Facial Nerve Diseases	1.4%
639	Craniocerebral Trauma	1.4%
640	Parasomnia	1.4%
641	Dyssomnias	1.4%
642	Vestibulocochlear Nerve Diseases	1.4%
643	Decerebrate State	1.4%
644	Hemiparesis	1.4%
645	Meningism	1.4%
646	Paresis	1.4%
647	Seizures	1.4%
648	Sensation Disorders	1.4%
649	Central Nervous System Neoplasms	1.4%
650	Complex partial seizures	1.4%
651	Monoparesis	1.4%
652	Neurogenic Inflammation	1.4%
653	Gait Disorders, Neurologic	1.4%
654	Neuromuscular Manifestations	1.4%
655	Jet Lag Syndrome	1.4%
656	Alice in Wonderland Syndrome	1.4%
657	Sweating, Gustatory	1.4%
658	Auriculotemporal Syndrome	1.4%
659	Dermal Sinus	1.4%
660	Spina Bifida Cystica	1.4%
661	Spina Bifida Occulta	1.4%
662	Lissencephaly	1.4%
663	Polymicrogyria	1.4%
664	Pachygyria	1.4%
665	Schizencephaly	1.4%
666	Periventricular Nodular Heterotopia	1.4%
667	Myasthenia Gravis, Autoimmune, Experimental	1.3%
668	Aortic coarctation	1.3%
669	Cor Triatriatum	1.3%
670	Coronary Vessel Anomalies	1.3%
671	Dental Enamel Hypoplasia	1.3%
672	Patent ductus arteriosus	1.3%
673	Ebstein Anomaly	1.3%
674	Heart Septal Defects	1.3%
675	Hyaline Membrane Disease	1.3%
676	Hypodontia	1.3%
677	Macrostomia	1.3%
678	Microstomia	1.3%
679	Multiple Sclerosis	1.3%
680	Tetralogy of Fallot	1.3%
681	Transposition of Great Vessels	1.3%
682	Hypoplastic Left Heart Syndrome	1.3%
683	May-Thurner Syndrome	1.3%
684	Craniofacial Dysostosis	1.3%
685	Wolff-Parkinson-White Syndrome	1.3%
686	Pupil Disorders	1.3%
687	Neurobehavioral Manifestations	1.3%
688	Paraneoplastic Encephalomyelitis	1.3%
689	Uveomeningoencephalitic Syndrome	1.2%
690	Sturge-Weber Syndrome	1.2%
691	Vertigo	1.2%
692	Alcohol-Induced Disorders, Nervous System	1.2%
693	Cluster Headache	1.2%
694	Migraine with Aura	1.2%
695	Familial Hemiplegic Migraine	1.2%
696	Chronic Paroxysmal Hemicrania	1.2%
697	SUNCT Syndrome	1.2%
698	Paroxysmal Hemicrania	1.2%
699	Ophthalmoplegia	1.2%
700	External Ophthalmoplegia	1.2%
701	Long QT Syndrome	1.2%
702	Platybasia	1.2%
703	Tricuspid Atresia	1.2%
704	Arrhythmogenic Right Ventricular Dysplasia	1.2%
705	Gonadal Dysgenesis	1.2%
706	Bronchomalacia	1.2%
707	Adrenogenital Syndrome	1.2%
708	Tracheomalacia	1.2%
709	Ovotesticular Disorders of Sex Development	1.2%
710	Micrognathism	1.2%
711	Pierre Robin Syndrome	1.2%
712	Spinal Cord Ischemia	1.2%
713	Hyperandrogenism	1.2%
714	Tuberculosis, Central Nervous System	1.2%
715	Vitamin K Deficiency	1.2%
716	Voice Disorders	1.2%
717	Voice Disturbance	1.2%
718	Choroid Plexus Papilloma	1.2%
719	Vocal Cord Paralysis	1.1%
720	West Nile Fever	1.1%
721	Retrognathia	1.1%
722	Reflex Sympathetic Dystrophy	1.1%
723	Nocturnal Myoclonus Syndrome	1.1%
724	Hyperprolactinemia	1.1%
725	Subclavian Steal Syndrome	1.1%
726	Pick Disease of the Brain	1.1%
727	Neuroaspergillosis	1.1%
728	Hematoma, Subdural	1.1%
729	Hematoma, Epidural, Cranial	1.1%
730	Folic Acid Deficiency	1.1%
731	Pellagra	1.1%
732	Thiamine Deficiency	1.1%
733	Vitamin B 12 Deficiency	1.1%
734	Vitamin B 6 Deficiency	1.1%
735	Pyridoxine Deficiency	1.1%
736	Prognathism	1.1%
737	Reflex, Abnormal	1.1%
738	Hyporeflexia	1.1%
739	Hyperreflexia	1.1%
740	Alcohol Withdrawal Seizures	1%
741	Pseudorabies	1%
742	Acromegaly	1%
743	Acrodynia	1%
744	Tardive Dyskinesia	1%
745	Sinus Thrombosis, Intracranial	1%
746	Neurosyphilis	1%
747	Cerebrospinal Fluid Otorrhea	0.9%
748	Cerebrospinal Fluid Rhinorrhea	0.9%
749	Neuritis, Autoimmune, Experimental	0.9%
750	Gait Ataxia	0.9%
751	Lyme Neuroborreliosis	0.9%
752	Beriberi	0.9%
753	Scurvy	0.9%
754	Aortopulmonary Septal Defect	0.9%
755	Double Outlet Right Ventricle	0.9%
756	Endocardial Cushion Defects	0.9%
757	Myocardial bridging	0.9%
758	Aorticopulmonary Septal Defect	0.9%
759	Akathisia	0.9%
760	Restlessness	0.9%
761	Psychomotor Agitation	0.9%
762	Prolactinoma	0.9%
763	Growth Hormone-Secreting Pituitary Adenoma	0.9%
764	Acoustic Neuroma	0.9%
765	Coma, Post-Head Injury	0.8%
766	Mandibulofacial Dysostosis	0.8%
767	Neuritis	0.8%
768	Polyneuritis	0.8%
769	Radiculitis	0.8%
770	Polyneuropathy	0.8%
771	Mononeuritis	0.8%
772	Mononeuropathies	0.8%
773	Brachial Plexus Neuropathies	0.8%
774	Radiculopathy	0.8%
775	Mononeuropathy Multiplex	0.8%
776	Nerve Root Compression	0.8%
777	Optic Nerve Glioma	0.8%
778	Romano-Ward Syndrome	0.8%
779	Brachial Plexus Neuritis	0.8%
780	Neuralgic Amyotrophy	0.8%
781	Anemia, Pernicious	0.8%
782	Hematoma, Subdural, Intracranial	0.8%
783	Hematoma, Subdural, Chronic	0.8%
784	Hematoma, Subdural, Acute	0.8%
785	Cavernous Sinus Thrombosis	0.8%
786	Sagittal Sinus Thrombosis	0.8%
787	Gait Apraxia	0.7%
788	Myositis	0.7%
789	Optic Atrophy	0.7%
790	Optic Neuritis	0.7%
791	Papilledema	0.7%
792	Strabismus	0.7%
793	Tolosa-Hunt Syndrome	0.7%
794	Isaacs syndrome	0.7%
795	Arsenic Poisoning	0.7%
796	Myotonic Disorders	0.7%
797	Multiple Sclerosis, Chronic Progressive	0.7%
798	Multiple Sclerosis, Relapsing-Remitting	0.7%
799	Diabetic Neuropathies	0.7%
800	Facial Injuries	0.7%
801	Facial Neuralgia	0.7%
802	Diabetic Amyotrophy	0.7%
803	Diabetic Autonomic Neuropathy	0.7%
804	Sleep Talking	0.7%
805	Manganese Poisoning	0.7%
806	Sleep Disorders, Intrinsic	0.7%
807	Orthostatic intolerance	0.7%
808	Anosmia	0.7%
809	Ataxia	0.7%
810	Athetosis	0.7%
811	Catalepsy	0.7%
812	Dystonia	0.7%
813	Hemiplegia	0.7%
814	Locked-In Syndrome	0.7%
815	Meningeal Neoplasms	0.7%
816	Muscle Hypertonia	0.7%
817	Muscle hypotonia	0.7%
818	Myoclonus	0.7%
819	Myotonia	0.7%
820	Neuralgia	0.7%
821	Paraplegia	0.7%
822	Pseudobulbar Palsy	0.7%
823	Quadriplegia	0.7%
824	Spasm	0.7%
825	Spastic Paraplegia	0.7%
826	Status Epilepticus	0.7%
827	Taste Disorders	0.7%
828	Tremor	0.7%
829	Monoplegia	0.7%
830	Hypokinesia	0.7%
831	Paraparesis	0.7%
832	Bradykinesia	0.7%
833	Waxy flexibility	0.7%
834	Action Tremor	0.7%
835	Resting Tremor	0.7%
836	Dysosmia	0.7%
837	Quadriparesis	0.7%
838	Mercury Poisoning, Nervous System	0.7%
839	Olfaction Disorders	0.7%
840	Myokymia	0.7%
841	Lead Poisoning, Nervous System	0.7%
842	Vestibular Neuronitis	0.7%
843	Somatosensory Disorders	0.7%
844	Neuropathic pain	0.7%
845	Hyperkinesia	0.7%
846	Intention tremor	0.7%
847	Anterior Spinal Artery Syndrome	0.7%
848	Waterhouse-Friderichsen Syndrome	0.7%
849	Nelson Syndrome	0.7%
850	Arteriovenous fistula	0.7%
851	Hand-Arm Vibration Syndrome	0.7%
852	Vision Disorders	0.7%
853	Metamorphopsia	0.7%
854	Visual Impairment	0.7%
855	Fibromyalgia	0.7%
856	Optic Neuropathy, Ischemic	0.7%
857	Anterior Ischemic Optic Neuropathy	0.7%
858	Medial Tibial Stress Syndrome	0.7%
859	Facial Hemiatrophy	0.7%
860	Melkersson-Rosenthal Syndrome	0.7%
861	Anisocoria	0.7%
862	Confusion	0.7%
863	Facial paralysis	0.7%
864	Lethargy	0.7%
865	Memory Disorders	0.7%
866	Muscle Cramp	0.7%
867	Perceptual Disorders	0.7%
868	Psychomotor Disorders	0.7%
869	Tonic Pupil	0.7%
870	Eosinophilia-Myalgia Syndrome	0.7%
871	Anhedonia	0.7%
872	Disorientation	0.7%
873	Facial Paresis	0.7%
874	Memory Loss	0.7%
875	Hemisensory Neglect	0.7%
876	Dysacusis	0.7%
877	Sleep Bruxism	0.7%
878	Muscular Atrophy	0.7%
879	Respiratory Paralysis	0.7%
880	Malaria, Cerebral	0.7%
881	Neurocysticercosis	0.7%
882	Truncus Arteriosus, Persistent	0.6%
883	Goldenhar Syndrome	0.6%
884	Tarsal Tunnel Syndrome	0.6%
885	Cauda Equina Syndrome	0.6%
886	Consciousness Disorders	0.6%
887	Mental Retardation	0.6%
888	Muscle Weakness	0.6%
889	Depressed Level of Consciousness	0.6%
890	Mental deficiency	0.6%
891	Intellectual Disability	0.6%
892	Bell Palsy	0.6%
893	Catatonia	0.6%
894	Herpes Zoster Oticus	0.6%
895	Aphonia	0.6%
896	Sleep Deprivation	0.6%
897	Dysphonia	0.6%
898	Talipes	0.6%
899	Carpal Tunnel Syndrome	0.6%
900	neurofibroma	0.6%
901	Sciatica	0.6%
902	Myalgia	0.6%
903	Hoarseness	0.5%
904	Alcohol Withdrawal Delirium	0.5%
905	Congenital clubfoot	0.5%
906	Vertical Talus	0.5%
907	Sciatic Neuropathy	0.4%
908	Ulnar Neuropathies	0.4%
909	Lesion of Sciatic Nerve	0.4%
910	Ulnar Neuritis	0.4%
911	Radial nerve compression	0.4%
912	Radial Tunnel Syndrome	0.4%
913	Peroneal Neuropathies	0.4%
914	Radial Neuropathy	0.4%
915	Median Neuropathy	0.4%
916	Sciatic Nerve Palsy	0.4%
917	Femoral Neuropathy	0.4%
918	Tibial Neuropathy	0.4%
919	Ulnar Nerve Palsy	0.4%
920	Postural Orthostatic Tachycardia Syndrome	0.4%
921	Radial nerve palsy	0.4%
922	Cubital Tunnel Syndrome	0.4%
923	Thoracic Outlet Syndrome	0.4%
924	Esotropia	0.4%
925	Exotropia	0.4%
926	Hypotension, Orthostatic	0.4%
927	Sleep Apnea Syndromes	0.4%
928	Polymyositis	0.4%
929	Post-Exercise Hypotension	0.4%
930	Disorders of Excessive Somnolence	0.4%
931	Sleep Initiation and Maintenance Disorders	0.4%
932	Night Terrors	0.4%
933	Somnambulism	0.4%
934	Trigeminal Nerve Disorder	0.4%
935	Transient Insomnia	0.4%
936	Sleep Paralysis	0.4%
937	Chronic Insomnia	0.4%
938	REM Sleep Behavior Disorder	0.4%
939	Hypersomnia	0.4%
940	Dysgeusia	0.4%
941	Formication	0.4%
942	Hyperalgesia	0.4%
943	Hyperesthesia	0.4%
944	Hypesthesia	0.4%
945	Language Disorders	0.4%
946	Numbness	0.4%
947	Paresthesia	0.4%
948	Paraparesis, Spastic	0.4%
949	Trismus	0.4%
950	Epilepsia Partialis Continua	0.4%
951	Hypogeusia	0.4%
952	Meningeal Carcinomatosis	0.4%
953	Brown-Sequard Syndrome	0.4%
954	Lockjaw	0.4%
955	Allodynia	0.4%
956	Lead Poisoning, Nervous System, Childhood	0.4%
957	Lead Poisoning, Nervous System, Adult	0.4%
958	Ageusia	0.4%
959	Eye Injuries	0.4%
960	Alexia	0.4%
961	Dyslexia	0.4%
962	Orbital Myositis	0.4%
963	Diplopia	0.4%
964	Muscle Rigidity	0.4%
965	Muscle Spasticity	0.4%
966	Scotoma	0.4%
967	Photophobia	0.4%
968	Cogwheel Rigidity	0.4%
969	Hemifacial Spasm	0.4%
970	Amaurosis	0.4%
971	Blindness	0.4%
972	Nuchal Rigidity	0.4%
973	Pyomyositis	0.4%
974	Agnosia	0.4%
975	Apraxias	0.4%
976	Hallucinations	0.4%
977	Hemianopsia	0.4%
978	Hyperacusis	0.4%
979	Tinnitus	0.4%
980	Visual Agnosia	0.4%
981	Anosognosia	0.4%
982	Wernicke-Korsakoff Syndrome	0.4%
983	Phonophobia	0.4%
984	Hearing Loss	0.4%
985	Sarcopenia	0.4%
986	Amnesia	0.3%
987	Delirium	0.3%
988	Dissociative Amnesia	0.3%
989	Color blindness	0.3%
990	Global Amnesia	0.3%
991	Meningioma	0.3%
992	Phantom pain	0.3%
993	Phantom Limb Pain	0.3%
994	Neurofibrosarcoma	0.3%
995	Polyradiculopathy	0.3%
996	Sleep Apnea, Obstructive	0.2%
997	Sleep Apnea, Central	0.2%
998	Narcolepsy	0.2%
999	Trigeminal Neuralgia	0.2%
1000	Kleine-Levin Syndrome	0.2%
1001	Agraphia	0.2%
1002	Anomia	0.2%
1003	Cluttering	0.2%
1004	Language Development Disorders	0.2%
1005	Speech Disorders	0.2%
1006	Syncope	0.2%
1007	Stupor	0.2%
1008	Dysgraphia	0.2%
1009	Presyncope	0.2%
1010	Dyslalia	0.2%
1011	Eye Burns	0.2%
1012	Amaurosis Fugax	0.2%
1013	Blindness, Cortical	0.2%
1014	Dyscalculia	0.2%
1015	Deafness	0.2%
1016	Hearing Loss, Sudden	0.2%
1017	Gerstmann Syndrome	0.2%
1018	Hearing Loss, Bilateral	0.2%
1019	Hearing Loss, High-Frequency	0.2%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.2%
1021	Prosopagnosia	0.2%
1022	Apraxia, Ideomotor	0.2%
1023	Charles Bonnet Syndrome	0.2%
1024	Hearing Loss, Unilateral	0.2%
1025	Complete Hearing Loss	0.2%
1026	Alien Hand Syndrome	0.2%
1027	Deaf Mutism	0.2%
1028	Dermatomyositis	0.2%
1029	Corneal Scar	0.2%
1030	Retrograde amnesia	0.2%
1031	Amnesia, Anterograde	0.2%
1032	Cataplexy	0.2%
1033	Aphasia	0.2%
1034	Articulation Disorders	0.2%
1035	Echolalia	0.2%
1036	Stuttering	0.2%
1037	Dysphasia	0.2%
1038	Mutism	0.1%
1039	Selective Mutism	0.1%
1040	Corneal Perforation	0.1%
1041	Dysarthria	0.1%
1042	Alexia, Pure	0.1%

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