MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

tegaserod

(IKBKZGMPCYNSLU-RGVLZGJSSA-N)

Structure

SMILES: CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N
Type(s): Approved; Investigational; Withdrawn
ATC code(s): A06AX06
Molecular Formula:: C16H23N5O
Molecular Weight:: 301.387
Log P:: 3.6961
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 3
TPSA:: 87.79
CAS Number(s):: 145158-71-0

Synonym(s)

tegaserod

5-methoxyindol-3-carboxaldehyde amino(pentylamino)methylenehydrazone hydrogen maleate

HTF 919

SDZ HTF 919

SDZ HTF-919

Zelmac

Zelnorm

tegaserod maleate

External Link(s)

MeSH	C105050
PubChem Compound	135409453 5362436
BindingDB	79022 50240618
ChEBI	51043 94540
CHEMBL	CHEMBL76370
DrugBank	DB01079
DrugCentral	2579
KEGG	dr:D06056
Therapeutic Target Database	D00XWD
ZINC	11676968

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal Pain	FAERS: 8		OFFSIDES SIDER US FAERS
2	Concomitant disease progression	FAERS: 7		OFFSIDES US FAERS
3	Asthenia	FAERS: 6		OFFSIDES SIDER US FAERS
4	Pelvic Pain	FAERS: 6		US FAERS
5	Uterine Polyp	FAERS: 6		OFFSIDES US FAERS
6	Cerebrovascular accident	FAERS: 5		US FAERS
7	Diverticulitis	FAERS: 4		OFFSIDES US FAERS
8	Appendicitis	FAERS: 3		OFFSIDES SIDER US FAERS
9	Constipation	FAERS: 3		US FAERS
10	Nephrolithiasis	FAERS: 3		US FAERS
11	Vomiting	FAERS: 3		SIDER US FAERS
12	Abdominal tenderness	FAERS: 2		OFFSIDES US FAERS
13	Atrial Fibrillation	FAERS: 2		US FAERS
14	Blood sodium increased	FAERS: 2		US FAERS
15	Cellulitis	FAERS: 2		US FAERS
16	Chest Pain	FAERS: 2		OFFSIDES SIDER US FAERS
17	Chest discomfort	FAERS: 2		US FAERS
18	Chills	FAERS: 2		US FAERS
19	Colitis	FAERS: 2		OFFSIDES US FAERS
20	Dehydration	FAERS: 2		US FAERS
21	Diverticulum	FAERS: 2		OFFSIDES US FAERS
22	Dizziness	FAERS: 2		OFFSIDES SIDER US FAERS
23	Dry skin	FAERS: 2		US FAERS
24	Nausea	FAERS: 2		OFFSIDES SIDER US FAERS
25	Pelvic mass	FAERS: 2		OFFSIDES US FAERS
26	Perianal abscess	FAERS: 2		OFFSIDES US FAERS
27	Poisoning	FAERS: 2		US FAERS
28	Back Pain	FAERS: 1		SIDER US FAERS
29	Blood prolactin increased	FAERS: 1		OFFSIDES US FAERS
30	Contraindicated product administered	FAERS: 1		US FAERS
31	Disease recurrence	FAERS: 1		OFFSIDES US FAERS
32	Drug Dependence	FAERS: 1		US FAERS
33	Drug exposure during pregnancy	FAERS: 1		US FAERS
34	Dyschezia	FAERS: 1		OFFSIDES US FAERS
35	Dyspepsia	FAERS: 1	15238200	CTD OFFSIDES SIDER US FAERS
36	Feeling abnormal	FAERS: 1		OFFSIDES US FAERS
37	Flatulence	FAERS: 1		OFFSIDES SIDER US FAERS
38	Formication	FAERS: 1		US FAERS
39	Hysterectomy	FAERS: 1		OFFSIDES US FAERS
40	Malaise	FAERS: 1		US FAERS
41	Menorrhagia	FAERS: 1		SIDER US FAERS
42	Menstrual discomfort	FAERS: 1		US FAERS
43	Myomectomy	FAERS: 1		US FAERS
44	Pulmonary Embolism	FAERS: 1		US FAERS
45	Skin irritation	FAERS: 1		US FAERS
46	Unintentional use for unapproved indication	FAERS: 1		US FAERS
47	Uterine Cancer	FAERS: 1		OFFSIDES US FAERS
48	Abasia			OFFSIDES
49	Abdominal Infection			OFFSIDES
50	Abdominal adhesions			OFFSIDES
51	Abdominal discomfort			OFFSIDES SIDER
52	Abdominal rebound tenderness			OFFSIDES
53	Abdominal rigidity			OFFSIDES
54	Acromegaly			OFFSIDES
55	Acute myocardial infarction			OFFSIDES
56	Acute sinusitis			OFFSIDES
57	Agitation			SIDER
58	Agraphia			OFFSIDES
59	Alanine Aminotransferase Increased			SIDER
60	Albuminuria			SIDER
61	Alopecia			OFFSIDES SIDER
62	Altered bowel function			OFFSIDES
63	Amnesia			OFFSIDES
64	Anal Fissure			OFFSIDES
65	Anal discomfort			OFFSIDES
66	Anal inflammation			OFFSIDES
67	Anal sphincter atony			OFFSIDES
68	Angina Pectoris			SIDER
69	Angiogram abnormal			OFFSIDES
70	Angioplasty			OFFSIDES
71	Anhedonia			OFFSIDES
72	Anhidrosis			OFFSIDES
73	Anorectal discomfort			SIDER
74	Aortic Aneurysm			OFFSIDES
75	Aortic Valve Prolapse			OFFSIDES
76	Aortic aneurysm repair			OFFSIDES
77	Aortic bruit			OFFSIDES
78	Aortic valve sclerosis			OFFSIDES
79	Apparent death			OFFSIDES
80	Appendectomy			OFFSIDES
81	Application site excoriation			OFFSIDES
82	Application site infection			OFFSIDES
83	Application site pustules			OFFSIDES
84	Arteriogram carotid abnormal			OFFSIDES
85	Arthropathy			OFFSIDES SIDER
86	Aspartate Aminotransferase Increased			SIDER
87	Asthma			SIDER
88	Atelectasis			OFFSIDES
89	Atherectomy			OFFSIDES
90	Atrial tachycardia			OFFSIDES
91	Autoimmune inner ear disease			OFFSIDES
92	Avascular necrosis			OFFSIDES
93	Bacteria urine identified			OFFSIDES
94	Bacterial Infections		12669766	CTD
95	Bacterial culture positive			OFFSIDES
96	Band neutrophil count increased			OFFSIDES
97	Band neutrophil percentage increased			OFFSIDES
98	Barium Enema			OFFSIDES
99	Barium enema abnormal			OFFSIDES
100	Bed rest			OFFSIDES
101	Benign Neoplasm			OFFSIDES
102	Benign neoplasm of spinal cord			OFFSIDES
103	Biliary Dyskinesia			OFFSIDES
104	Biliary dilatation			OFFSIDES
105	Biopsy intestine abnormal			OFFSIDES
106	Biopsy rectum abnormal			OFFSIDES
107	Biopsy site unspecified abnormal			OFFSIDES
108	Biopsy small intestine abnormal			OFFSIDES
109	Biopsy stomach abnormal			OFFSIDES
110	Bipolar Disorder			OFFSIDES
111	Bladder cancer recurrent			OFFSIDES
112	Bladder discomfort			OFFSIDES
113	Blood Glucose			OFFSIDES
114	Blood bicarbonate			OFFSIDES
115	Blood bilirubin abnormal			OFFSIDES
116	Blood blister			OFFSIDES
117	Blood chloride increased			OFFSIDES
118	Blood creatine phosphokinase MB increased			OFFSIDES
119	Blood potassium decreased			OFFSIDES
120	Blood pressure fluctuation			OFFSIDES
121	Blood thyroid stimulating hormone increased			OFFSIDES
122	Blood urea abnormal			OFFSIDES
123	Body fat disorder			OFFSIDES
124	Bowel movement irregularity			OFFSIDES
125	Breast Cyst			OFFSIDES
126	Breast discomfort			OFFSIDES
127	Breast engorgement			OFFSIDES
128	Breast tenderness			OFFSIDES
129	Bronchitis			OFFSIDES
130	Burning sensation			OFFSIDES
131	Bursitis			OFFSIDES
132	Caffeine consumption			OFFSIDES
133	Cardiac Flutter			OFFSIDES
134	Cardiac ablation			OFFSIDES
135	Cardiac discomfort			OFFSIDES
136	Cardiac enzymes increased			OFFSIDES
137	Cardiac procedure complication			OFFSIDES
138	Cardiac stress test abnormal			OFFSIDES
139	Cardiac valve replacement complication			OFFSIDES
140	Cardioactive drug level increased			OFFSIDES
141	Cardiovascular insufficiency			OFFSIDES
142	Carotid artery occlusion			OFFSIDES
143	Carotid bruit			OFFSIDES
144	Carotid intima-media thickness increased			OFFSIDES
145	Carotidynia			OFFSIDES
146	Catheter placement			OFFSIDES
147	Catheter sepsis			OFFSIDES
148	Cerebral Palsy			OFFSIDES
149	Cerebral ventricle dilatation			OFFSIDES
150	Cerebrovascular stenosis			OFFSIDES
151	Cervicobrachial syndrome			OFFSIDES
152	Choking sensation			OFFSIDES
153	Cholecystitis			SIDER
154	Cholelithiasis			SIDER
155	Chondromalacia			OFFSIDES
156	Clostridium colitis			OFFSIDES
157	Clubbing			OFFSIDES
158	Coital bleeding			OFFSIDES
159	Cold sweat			OFFSIDES
160	Colectomy			OFFSIDES
161	Colitis erosive			OFFSIDES
162	Colon adenoma			OFFSIDES
163	Coronary angioplasty			OFFSIDES
164	Coronary artery dilatation			OFFSIDES
165	Creatinine renal clearance increased			OFFSIDES
166	Cyclothymic Disorder			OFFSIDES
167	Cystocele			OFFSIDES
168	Cyst			OFFSIDES SIDER
169	Deafness			OFFSIDES
170	Delusional disorder, unspecified type			OFFSIDES
171	Demyelination			OFFSIDES
172	Dental prosthesis placement			OFFSIDES
173	Dermatitis			SIDER
174	Diarrhea		20350559	CTD OFFSIDES
175	Diastolic dysfunction			OFFSIDES
176	Diverticulosis			OFFSIDES
177	Drug abuser			OFFSIDES
178	Drug exposure via breast milk			OFFSIDES
179	Drug withdrawal headache			OFFSIDES
180	Dyspareunia			OFFSIDES
181	Ear and labyrinth disorders			SIDER
182	Ear congestion			OFFSIDES
183	Ear discomfort			OFFSIDES
184	Echocardiogram abnormal			OFFSIDES
185	Echocardiogram normal			OFFSIDES
186	Economic problem			OFFSIDES
187	Ejection Fraction Decreased			OFFSIDES
188	Ejection fraction abnormal			OFFSIDES
189	Electrocardiogram ST segment abnormal			OFFSIDES
190	Electrocardiogram ST-T change			OFFSIDES
191	Electrocardiogram ST-T segment abnormal			OFFSIDES
192	Electrocardiogram repolarisation abnormality			OFFSIDES
193	Embolism			OFFSIDES
194	Emotional disorder			OFFSIDES
195	Emotional distress			OFFSIDES
196	Endometriosis			OFFSIDES
197	Endoscopy abnormal			OFFSIDES
198	Enteritis			OFFSIDES
199	Eosinophil percentage increased			OFFSIDES
200	Eosinophilia			SIDER
201	Eructation			SIDER
202	Erythema Infectiosum			OFFSIDES
203	Essential Hypertension			OFFSIDES
204	Exploratory operation			OFFSIDES
205	Exposure to chemical pollution			OFFSIDES
206	Fatigue			OFFSIDES SIDER
207	Fibromuscular Dysplasia			OFFSIDES
208	Fibromyalgia			OFFSIDES
209	Flank Pain			OFFSIDES
210	Flushing			SIDER
211	Food craving			OFFSIDES
212	Foreign body sensation in eyes			OFFSIDES
213	Gastric emptying study			OFFSIDES
214	Gastritis			SIDER
215	Gastrointestinal Pain			SIDER
216	Gastrointestinal infection			OFFSIDES
217	Gastrointestinal motility disorder			OFFSIDES
218	Gastrointestinal mucosal disorder			OFFSIDES
219	Gastrointestinal obstruction			OFFSIDES
220	Gastroparesis		15961989 17536982	CTD
221	Genital pain			OFFSIDES
222	Genital rash			OFFSIDES
223	Hay fever			OFFSIDES
224	Headache aggravated			SIDER
225	Headache			SIDER
226	Hemiparesis			OFFSIDES
227	Hepatitis C antibody positive			OFFSIDES
228	Hepatitis			OFFSIDES SIDER
229	Hepatobiliary scan			OFFSIDES
230	Hepatotoxicity			OFFSIDES
231	Herpes simplex DNA test positive			OFFSIDES
232	High frequency ablation			OFFSIDES
233	Hormone level abnormal			OFFSIDES
234	Hydrocephalus			OFFSIDES
235	Hydronephrosis			OFFSIDES
236	Hypersensitivity			SIDER
237	Hypoaesthesia facial			OFFSIDES
238	Hypogeusia			OFFSIDES
239	Hypokinesia			OFFSIDES
240	Hypotension			SIDER
241	Ileal ulcer			OFFSIDES
242	Ileitis			OFFSIDES
243	Impaired gastric emptying			OFFSIDES
244	Implantable defibrillator insertion			OFFSIDES
245	Incoherent			OFFSIDES
246	Infection			SIDER
247	Infestation			SIDER
248	Influenza serology positive			OFFSIDES
249	Injection site cellulitis			OFFSIDES
250	Injection site infection			OFFSIDES
251	Intermediate density lipoprotein increased			OFFSIDES
252	Intermittent Claudication			OFFSIDES
253	Intestinal Fistula			OFFSIDES
254	Intestinal Obstruction			OFFSIDES
255	Intestinal Perforation			OFFSIDES
256	Intestinal infarction			OFFSIDES
257	Intestinal polypectomy			OFFSIDES
258	Intestinal resection			OFFSIDES
259	Intrinsic factor antibody negative			OFFSIDES
260	Irritable Bowel Syndrome		15961989	CTD
261	Joint Instability			OFFSIDES
262	Joint Range of Motion Decreased			OFFSIDES
263	Joint injury			OFFSIDES
264	Laboratory test interference			OFFSIDES
265	Lactobacillus infection			OFFSIDES
266	Laparoscopy abnormal			OFFSIDES
267	Laparoscopy			OFFSIDES
268	Laparotomy			OFFSIDES
269	Large intestine anastomosis			OFFSIDES
270	Large intestine perforation			OFFSIDES
271	Lightheadedness			SIDER
272	Limb discomfort			OFFSIDES
273	Limb injury			OFFSIDES
274	Lipase			OFFSIDES
275	MELAS Syndrome			OFFSIDES
276	Mallory-Weiss Syndrome			OFFSIDES
277	Malnutrition			SIDER
278	Mastectomy			OFFSIDES
279	Mechanical urticaria			OFFSIDES
280	Medical device implantation			OFFSIDES
281	Meningocele			OFFSIDES
282	Meniscus operation			OFFSIDES
283	Mesenteric vascular insufficiency			OFFSIDES SIDER
284	Metatarsalgia			OFFSIDES
285	Migraine with Aura			OFFSIDES
286	Mixed Connective Tissue Disease			OFFSIDES
287	Mood swings			SIDER
288	Multiple allergies			OFFSIDES
289	Muscle Fatigue			OFFSIDES
290	Muscle Weakness			OFFSIDES
291	Musculoskeletal Pain			OFFSIDES
292	Musculoskeletal discomfort			SIDER
293	Myalgia			SIDER
294	Mycobacterium chelonei infection			OFFSIDES
295	Myocardial fibrosis			OFFSIDES
296	Nerve Block			OFFSIDES
297	Nodule			OFFSIDES
298	Obstruction			OFFSIDES
299	Ocular icterus			OFFSIDES
300	Oligomenorrhea			OFFSIDES
301	Open reduction of fracture			OFFSIDES
302	Open wound			OFFSIDES
303	Oral polypectomy			OFFSIDES
304	Oropharyngeal swelling			OFFSIDES
305	Oxygen supplementation			OFFSIDES
306	PCO2 decreased			OFFSIDES
307	Pain			OFFSIDES SIDER
308	Panniculitis			OFFSIDES
309	Parenteral Nutrition			OFFSIDES
310	Pedal pulse decreased			OFFSIDES
311	Pelvic fluid collection			OFFSIDES
312	Peridiverticulitis			OFFSIDES
313	Pharyngitis			SIDER
314	Pharyngolaryngeal Pain			SIDER
315	Physical disability			OFFSIDES
316	Polyuria			SIDER
317	Poor dental condition			OFFSIDES
318	Postmenopause			OFFSIDES
319	Postoperative adhesion			OFFSIDES
320	Postoperative ileus			OFFSIDES
321	Postoperative thrombosis			OFFSIDES
322	Postoperative wound complication			OFFSIDES
323	Postpericardiotomy Syndrome			OFFSIDES
324	Procedural site reaction			OFFSIDES
325	Proctitis			OFFSIDES
326	Productive Cough			OFFSIDES
327	Prolapse repair			OFFSIDES
328	Protein S decreased			OFFSIDES
329	Pruritus			SIDER
330	Pulmonary arterial pressure increased			OFFSIDES
331	Pyloric Stenosis			OFFSIDES
332	Quality of life decreased			OFFSIDES
333	Rectal Prolapse			OFFSIDES
334	Rectal tenesmus			SIDER
335	Rectocele			OFFSIDES
336	Reflux gastritis			OFFSIDES
337	Regurgitation of food			OFFSIDES
338	Renal artery occlusion			OFFSIDES
339	Renal pain			SIDER
340	Respiratory Therapy			OFFSIDES
341	Respiratory fume inhalation disorder			OFFSIDES
342	Respiratory tract infection fungal			OFFSIDES
343	Retinal vascular occlusion			OFFSIDES
344	Rhonchi			OFFSIDES
345	Sacroiliitis			OFFSIDES
346	Serositis			OFFSIDES
347	Shock			SIDER
348	Sick Sinus Syndrome			OFFSIDES
349	Sigmoidoscopy abnormal			OFFSIDES
350	Sinus bradycardia			OFFSIDES
351	Sinusitis			SIDER
352	Spasm of sphincter of Oddi			SIDER
353	Sphincter of Oddi Dysfunction			SIDER
354	Spina Bifida			OFFSIDES
355	Spinal fusion surgery			OFFSIDES
356	Sputum culture positive			OFFSIDES
357	Steroid withdrawal syndrome			OFFSIDES
358	Stool analysis abnormal			OFFSIDES
359	Stress			OFFSIDES
360	Subileus			SIDER
361	Suicide attempt			SIDER
362	Supraventricular tachycardia			SIDER
363	Syncope			SIDER
364	Tachyphylaxis			OFFSIDES
365	Talipes			OFFSIDES
366	Temperature intolerance			OFFSIDES
367	Tenosynovitis			OFFSIDES
368	Testis discomfort			OFFSIDES
369	Therapeutic procedure			OFFSIDES
370	Therapeutic response unexpected			OFFSIDES
371	Thoracotomy			OFFSIDES
372	Tracheitis			OFFSIDES
373	Transaminases increased			OFFSIDES SIDER
374	Trauma			SIDER
375	Troponin I increased			OFFSIDES
376	Troponin T			OFFSIDES
377	Troponin increased			OFFSIDES
378	Ultrasound abdomen abnormal			OFFSIDES
379	Ultrasound antenatal screen			OFFSIDES
380	Ultrasound scan abnormal			OFFSIDES
381	Unexpected therapeutic drug effect			OFFSIDES
382	Upset stomach			SIDER
383	Urinary tract infection			SIDER
384	Urine bilirubin increased			OFFSIDES
385	Urine output increased			SIDER
386	Urticaria			SIDER
387	Vaginal burning sensation			OFFSIDES
388	Vascular bypass dysfunction			OFFSIDES
389	Vascular bypass graft			OFFSIDES
390	Vascular calcification			OFFSIDES
391	Vascular insufficiency			OFFSIDES
392	Vena cava filter insertion			OFFSIDES
393	Venous stenosis			OFFSIDES
394	Ventricular hypokinesia			OFFSIDES
395	Vertigo			SIDER
396	Very low density lipoprotein increased			OFFSIDES
397	Viral myositis			OFFSIDES
398	Visual Impairment			SIDER
399	Visual disturbance			OFFSIDES SIDER
400	Vitamin A Deficiency			OFFSIDES
401	Vulvovaginal discomfort			OFFSIDES
402	Walking aid user			OFFSIDES
403	Weight Gain			OFFSIDES
404	angiogram			OFFSIDES
405	colonoscopy			OFFSIDES
406	effusion			OFFSIDES

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234