MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Craniofacial Dysostosis

(UMLS:C0010273)

Definition:: Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.
UMLS ID:: C0010273
MeSH ID:: D003394

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.231|C05.660.207.231

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.231

Synonym(s)

Craniofacial Dysostosis

Acrocephalosyndactyly, type II

Apert-Crouzon syndrome

Craniofacial dysostosis

Craniofacial dysostosis syndrome

Crouzon

Crouzon Syndrome

Crouzon syndrome

Crouzon's Disease

10.

Crouzon's disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 3		US FAERS
2	Paroxetine	FAERS: 3		US FAERS
3	Losartan	FAERS: 2		US FAERS
4	Mycophenolic Acid	FAERS: 2		US FAERS
5	Modafinil	FAERS: 1		US FAERS
6	Ondansetron	FAERS: 1		US FAERS
7	Paroxetine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Mycophenolic Acid		18238994	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Craniosynostosis	46.8%
2	Brachycephaly	46.8%
3	Platybasia	46.5%
4	Klippel-Feil Syndrome	42.5%
5	Synostosis	42.5%
6	Plagiocephaly	39.9%
7	Pectus excavatum	38.3%
8	Rubinstein-Taybi Syndrome	37.7%
9	Acrocephalosyndactylia	37.5%
10	Syndactyly	33.8%
11	Pectus carinatum	33.6%
12	Maxillofacial Abnormalities	33.2%
13	Arthrogryposis	32%
14	Microcephaly	30.4%
15	Macrocephaly	30.4%
16	Limb Deformities, Congenital	29.3%
17	Holoprosencephaly	28.9%
18	Poland Syndrome	25.7%
19	Noonan Syndrome	24.6%
20	Gastroschisis	24.3%
21	Porencephaly	23%
22	Jaw Abnormalities	23%
23	Antley-Bixler Syndrome Phenotype	22.7%
24	Osteoarthropathy, Secondary Hypertrophic	21.6%
25	Gigantism	20.9%
26	Multiple Epiphyseal Dysplasia	20%
27	Osteochondrodysplasias	20%
28	Amelia	19%
29	Arachnodactyly	19%
30	Ectromelia	19%
31	Hemimelia	19%
32	Phocomelia	19%
33	Sirenomelia	19%
34	Polydactyly	19%
35	Brachydactyly	19%
36	Lower Extremity Deformities, Congenital	19%
37	Upper Extremity Deformities, Congenital	19%
38	Osteochondritis	18%
39	Micrognathism	17.7%
40	Pierre Robin Syndrome	17.7%
41	Hyperostosis	17.5%
42	Osteitis	17.5%
43	Osteitis Deformans	17.5%
44	Osteochondrosis	17.5%
45	Spinal Diseases	17.5%
46	Dwarfism	17.2%
47	Prognathism	16.7%
48	Fasciitis	16.4%
49	Foot Deformities	16.4%
50	Arthropathy	16.4%
51	Retrognathia	16%
52	Marfan Syndrome	15.1%
53	Cleft Palate	15%
54	Contracture	14.9%
55	Fasciitis, Plantar	14.9%
56	Talipes	14.8%
57	Bone Diseases, Endocrine	14.6%
58	Spinal Neoplasms	14.3%
59	Spondylitis	14.3%
60	Bone Diseases, Infectious	14.2%
61	Bone neoplasms	14.2%
62	Osteopenia	14.2%
63	Bone Resorption	14%
64	Aseptic Necrosis of Bone	14%
65	Chondrodysplasia Punctata	13.8%
66	Enchondromatosis	13.8%
67	Osteosclerosis	13.8%
68	Kashin-Beck Disease	13.8%
69	Congenital Hypothyroidism	13.7%
70	Jaw Diseases	13.6%
71	Laryngomalacia	13.6%
72	Cartilage Diseases	13.2%
73	Foot Diseases	13.2%
74	Myopathy	13.2%
75	Rheumatism	13.2%
76	Chondromalacia	13.2%
77	Abnormalities, Drug-Induced	12.5%
78	Situs Inversus	12.5%
79	Fibromyalgia	12.4%
80	Polymyalgia Rheumatica	12.4%
81	Metatarsalgia	12.3%
82	Osteogenesis Imperfecta	12.2%
83	Nail-Patella Syndrome	12%
84	Congenital clubfoot	11.9%
85	Vertical Talus	11.9%
86	Cockayne Syndrome	11.7%
87	Beckwith-Wiedemann Syndrome	11.5%
88	Wolf-Hirschhorn Syndrome	11.5%
89	Basal Cell Nevus Syndrome	11.5%
90	Gout	11.2%
91	Osteoarthritis, Spine	11.1%
92	Ainhum	10.7%
93	Spinal Stenosis	10.7%
94	Spondylosis	10.7%
95	Intervertebral Disc Degeneration	10.7%
96	Melorheostosis	10.5%
97	Osteopetrosis	10.5%
98	Eye Abnormalities	10.4%
99	Cardiovascular Abnormalities	10.4%
100	Skin Abnormalities	10.1%
101	Lymphatic Abnormalities	10.1%
102	Congenital Microtia	10.1%
103	Aicardi's syndrome	10%
104	Smith-Magenis syndrome	10%
105	Rheumatic Fever	9.9%
106	Congenital diaphragmatic hernia	9.9%
107	Ischemic contracture	9.9%
108	Cri-du-Chat Syndrome	9.9%
109	Down Syndrome	9.9%
110	Trisomy 21	9.9%
111	Bronchomalacia	9.8%
112	Tracheomalacia	9.8%
113	Temporomandibular Joint Disorders	9.7%
114	Discitis	9.7%
115	Hip Contracture	9.2%
116	Periarthritis	9.2%
117	Ankylosing spondylitis	9.2%
118	Arthritis	9.2%
119	Bursitis	9.2%
120	Joint Instability	9.2%
121	Myofascial Pain Syndromes	9.2%
122	Rhabdomyolysis	9.2%
123	Synovitis	9.2%
124	Joint laxity	9.2%
125	Polyarthritis	9.2%
126	Frozen shoulder	9.2%
127	Patellofemoral Pain Syndrome	9.2%
128	Urogenital Abnormalities	8.7%
129	Ectodermal Dysplasia	8.7%
130	Aplasia Cutis Congenita	8.7%
131	Rheumatoid Arthritis	8.7%
132	Juvenile arthritis	8.7%
133	Eosinophilic Granuloma	8.6%
134	Bone Diseases	8.6%
135	Prader-Willi Syndrome	8.6%
136	Osteomyelitis	8.6%
137	Osteoporosis	8.6%
138	Periostitis	8.6%
139	Bone Demineralization, Pathologic	8.6%
140	Post-Traumatic Osteoporosis	8.6%
141	Alveolar Bone Loss	8.5%
142	Femur Head Necrosis	8.5%
143	Osteolysis	8.5%
144	Temporomandibular Joint Dysfunction Syndrome	8.4%
145	Tuberculosis, Spinal	8.3%
146	Anencephaly	8.2%
147	Arthritis, Psoriatic	7.9%
148	Osteoarthritis, Knee	7.8%
149	CHARGE Syndrome	7.8%
150	Spondylarthropathies	7.8%
151	Genetic Diseases, Inborn	7.8%
152	Arthritis, Gouty	7.5%
153	Compartment syndromes	7.4%
154	Maxillary Diseases	7.4%
155	Tendinitis	7.4%
156	Tendinopathy	7.4%
157	Prune Belly Syndrome	7.4%
158	Twins, Conjoined	7.4%
159	Waardenburg Syndrome	7.4%
160	Hemarthrosis	7.3%
161	Myositis	7.3%
162	Tietze's Syndrome	7.3%
163	Isaacs syndrome	7.3%
164	Myotonic Disorders	7.3%
165	Lordosis	7.3%
166	Spondylolysis	7.3%
167	kyphosis	7.3%
168	Dural Arteriovenous Fistula	7.1%
169	Acromegaly	7.1%
170	Joint Tuberculosis	7.1%
171	Tuberculosis, Osteoarticular	7.1%
172	Bone Tuberculosis	7.1%
173	Dextrocardia	7%
174	Arthritis, Reactive	6.9%
175	Kartagener Syndrome	6.9%
176	Xeroderma	6.7%
177	Mobius Syndrome	6.7%
178	Muscular Dystrophy	6.6%
179	Rheumatoid Nodule	6.5%
180	Fetal Diseases	6.2%
181	Abnormalities, Radiation-Induced	6.2%
182	Medial Tibial Stress Syndrome	6.2%
183	Pseudohypoparathyroidism	6.1%
184	Familial Periodic Paralysis	6.1%
185	Mitochondrial Myopathies	6.1%
186	Rickets	6.1%
187	Muscle Cramp	6.1%
188	Eosinophilia-Myalgia Syndrome	6.1%
189	Muscle Rigidity	6%
190	Muscle Spasticity	6%
191	Cogwheel Rigidity	6%
192	Nuchal Rigidity	6%
193	Anophthalmos	6%
194	Anus, Imperforate	6%
195	Hydranencephaly	6%
196	Microphthalmos	6%
197	Neural Tube Defects	6%
198	Tethered Cord Syndrome	6%
199	Iniencephaly	6%
200	Craniorachischisis	6%
201	Exencephaly	6%
202	Septo-Optic Dysplasia	6%
203	Cortical Dysplasia	6%
204	Malformations of Cortical Development	6%
205	Anorectal Malformations	6%
206	Bloom Syndrome	5.9%
207	Myotonic Dystrophy	5.9%
208	Osteoporosis, Postmenopausal	5.8%
209	Bunion	5.7%
210	Fibrodysplasia Ossificans Progressiva	5.7%
211	Myoglobinuria	5.7%
212	Myositis Ossificans	5.7%
213	Tenosynovitis	5.7%
214	Sacroiliitis	5.7%
215	Spondylolisthesis	5.7%
216	Scimitar Syndrome	5.6%
217	Felty Syndrome	5.6%
218	Polycystic Kidney Diseases	5.6%
219	Williams Syndrome	5.6%
220	Chronic Fatigue Syndrome	5.4%
221	Giant Cell Epulis	5.3%
222	Muscle Weakness	5.3%
223	Musculoskeletal Pain	5.2%
224	Arthralgia	5.2%
225	Polyarthralgia	5.2%
226	Alstrom Syndrome	5.2%
227	Muscular Dystrophy, Duchenne	5.1%
228	Retinal Dysplasia	5.1%
229	Palatal Neoplasms	5.1%
230	Blepharophimosis	5.1%
231	Laryngostenosis	5.1%
232	Mouth Abnormalities	5.1%
233	Aniridia	5%
234	Bone Diseases, Developmental	5%
235	Esophageal Atresia	5%
236	Intestinal Atresia	5%
237	Horseshoe Kidney	5%
238	Epidermolysis Bullosa	5%
239	Acrodermatitis	4.9%
240	Lymphangiectasis, Intestinal	4.9%
241	Gianotti-Crosti Syndrome	4.9%
242	Cystic Fibrosis	4.9%
243	Rheumatoid Vasculitis	4.9%
244	Mastoiditis	4.9%
245	Petrositis	4.9%
246	Fragile X Syndrome	4.8%
247	Myotonia Congenita	4.7%
248	Smith-Lemli-Opitz Syndrome	4.7%
249	Arthritis, Infectious	4.7%
250	Ichthyosis, X-Linked	4.6%
251	Anterior Compartment Syndrome	4.6%
252	Enthesopathy	4.6%
253	Arthritis, Experimental	4.6%
254	Abdominal Compartment Syndrome	4.6%
255	Polymyositis	4.6%
256	Myalgia	4.5%
257	Primary Ciliary Dyskinesia	4.5%
258	Choanal Atresia	4.4%
259	Tracheobronchomegaly	4.4%
260	Laryngocele	4.4%
261	Sicca Syndrome	4.4%
262	Sjogren's Syndrome	4.4%
263	Welander Distal Myopathy	4.3%
264	Choledochal Cyst	4.3%
265	Hermaphroditism	4.3%
266	Disorders of Sex Development	4.3%
267	Cryptorchidism	4.3%
268	Hypospadias	4.3%
269	Central Nervous System Cysts	4.3%
270	Dandy-Walker Syndrome	4.2%
271	Meconium Aspiration Syndrome	4.2%
272	Turner Syndrome	4.2%
273	POEMS Syndrome	4.2%
274	Abdominal Cramps	4.2%
275	Amniotic Band Syndrome	4.2%
276	Asphyxia Neonatorum	4.2%
277	Infant, Premature, Diseases	4.2%
278	Infantile Colic	4.2%
279	Osteomalacia	4.1%
280	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
281	Pseudoxanthoma Elasticum	4%
282	Hypokalemic periodic paralysis	3.9%
283	Hip Dislocation	3.9%
284	Shoulder Dislocation	3.9%
285	Hip Dysplasia	3.9%
286	Ectopia Cordis	3.9%
287	Meningomyelocele	3.9%
288	Spina Bifida	3.9%
289	Single umbilical artery	3.9%
290	Orbital Myositis	3.9%
291	Dupuytren Contracture	3.9%
292	Pyomyositis	3.8%
293	Bladder Exstrophy	3.7%
294	Epispadias	3.7%
295	Multicystic Dysplastic Kidney	3.7%
296	Polycystic Kidney, Autosomal Dominant	3.7%
297	Sjogren-Larsson Syndrome	3.7%
298	Xeroderma Pigmentosum	3.6%
299	Neoplastic Syndromes, Hereditary	3.5%
300	Kallmann Syndrome	3.5%
301	Klinefelter Syndrome	3.4%
302	Anemia, Neonatal	3.3%
303	Pelger-Huet Anomaly	3.3%
304	Persistent Fetal Circulation Syndrome	3.3%
305	Werner Syndrome	3.3%
306	Craniofacial Abnormalities	3.3%
307	Myasthenic Syndromes, Congenital	3.3%
308	Umbilical hernia	3.3%
309	Aortic coarctation	3.3%
310	Cor Triatriatum	3.3%
311	Coronary Vessel Anomalies	3.3%
312	Dental Enamel Hypoplasia	3.3%
313	Patent ductus arteriosus	3.3%
314	Dysostoses	3.3%
315	Ebstein Anomaly	3.3%
316	Heart Septal Defects	3.3%
317	Hypodontia	3.3%
318	Macrostomia	3.3%
319	Meningocele	3.3%
320	Microstomia	3.3%
321	Tetralogy of Fallot	3.3%
322	Transposition of Great Vessels	3.3%
323	Hypoplastic Left Heart Syndrome	3.3%
324	May-Thurner Syndrome	3.3%
325	Encephalocele	3.3%
326	Zellweger Syndrome	3.3%
327	Craniofacial Dysostosis	3.3%
328	Charcot-Marie-Tooth Disease	3.2%
329	Wolff-Parkinson-White Syndrome	3.2%
330	Shoulder Pain	3.2%
331	Hyperkeratosis, Epidermolytic	3%
332	Nose Neoplasms	3%
333	Tuberous Sclerosis	2.9%
334	Renal Osteodystrophy	2.9%
335	Renal rickets	2.9%
336	Dermal Sinus	2.9%
337	Spina Bifida Cystica	2.9%
338	Spina Bifida Occulta	2.9%
339	Lissencephaly	2.9%
340	Polymicrogyria	2.9%
341	Pachygyria	2.9%
342	Schizencephaly	2.9%
343	Periventricular Nodular Heterotopia	2.9%
344	Mitochondrial Encephalomyopathies	2.9%
345	Neonatal Abstinence Syndrome	2.8%
346	Long QT Syndrome	2.8%
347	Tricuspid Atresia	2.8%
348	Arrhythmogenic Right Ventricular Dysplasia	2.8%
349	Anemia, Sickle Cell	2.8%
350	Thalassemia	2.8%
351	Gonadal Dysgenesis	2.8%
352	Adrenogenital Syndrome	2.8%
353	Ovotesticular Disorders of Sex Development	2.8%
354	Fetal Growth Retardation	2.8%
355	Refsum Disease	2.8%
356	Fetal Hypoxia	2.8%
357	Congenital nystagmus	2.8%
358	Fetal Alcohol Spectrum Disorders	2.8%
359	Toxoplasmosis, Congenital	2.7%
360	Syphilis, Congenital	2.7%
361	Albinism	2.6%
362	Hyperandrogenism	2.6%
363	Familial Mediterranean Fever	2.5%
364	Aortopulmonary Septal Defect	2.4%
365	Double Outlet Right Ventricle	2.4%
366	Endocardial Cushion Defects	2.4%
367	Myocardial bridging	2.4%
368	Aorticopulmonary Septal Defect	2.4%
369	Autoimmune Lymphoproliferative Syndrome	2.4%
370	Congenital Hyperinsulinism	2.4%
371	Dermatomyositis	2.4%
372	Chorioamnionitis	2.4%
373	Angioedemas, Hereditary	2.3%
374	Wiskott-Aldrich Syndrome	2.2%
375	Rett Syndrome	2.2%
376	Familial Hypophosphatemic Rickets	2.1%
377	Mandibulofacial Dysostosis	2.1%
378	Romano-Ward Syndrome	2.1%
379	Mucopolysaccharidosis II	2%
380	Truncus Arteriosus, Persistent	2%
381	Goldenhar Syndrome	2%
382	Paralysis, Obstetric	2%
383	Retinopathy of Prematurity	2%
384	Menkes Kinky Hair Syndrome	2%
385	Amino Acid Metabolism, Inborn Errors	2%
386	Carbohydrate Metabolism, Inborn Errors	2%
387	Metal Metabolism, Inborn Errors	2%
388	Progeria	2%
389	Lysosomal Storage Diseases	2%
390	Cytochrome-c Oxidase Deficiency	2%
391	Peroxisomal Disorders	2%
392	Bronchopulmonary Dysplasia	2%
393	MELAS Syndrome	1.9%
394	Sickle Cell Trait	1.8%
395	Neuronal Ceroid-Lipofuscinoses	1.8%
396	Ophthalmia Neonatorum	1.8%
397	Respiratory Distress Syndrome, Newborn	1.7%
398	Ataxia Telangiectasia	1.7%
399	Cutis Laxa	1.7%
400	Retinitis Pigmentosa	1.7%
401	Pigmentary retinopathy	1.7%
402	Porokeratosis	1.6%
403	Keratoderma, Palmoplantar	1.6%
404	Chronic granulomatous disease	1.6%
405	Hepatolenticular Degeneration	1.6%
406	Arteriovenous fistula	1.6%
407	Amyloid Neuropathies, Familial	1.6%
408	Radicular Cyst	1.6%
409	Adrenoleukodystrophy	1.6%
410	Hydrops Fetalis	1.5%
411	Acute Chest Syndrome	1.5%
412	Duane Retraction Syndrome	1.4%
413	Galactosemias	1.4%
414	Urea Cycle Disorders, Inborn	1.4%
415	Tyrosinemias	1.4%
416	Fabry Disease	1.4%
417	Porphyrias, Hepatic	1.4%
418	Peutz-Jeghers Syndrome	1.4%
419	Thrombasthenia	1.4%
420	Antithrombin III Deficiency	1.4%
421	Protein C Deficiency	1.4%
422	Brain Diseases, Metabolic, Inborn	1.4%
423	Afibrinogenemia	1.4%
424	Dystonia Musculorum Deformans	1.4%
425	Factor VII Deficiency	1.4%
426	Factor X Deficiency	1.4%
427	Factor XII Deficiency	1.4%
428	Hemophilia A	1.4%
429	Leukomalacia, Periventricular	1.4%
430	Activated Protein C Resistance	1.4%
431	Factor II deficiency	1.4%
432	Factor VIII Deficiency	1.4%
433	Factor V deficiency	1.4%
434	Factor XI Deficiency	1.4%
435	Hypoprothrombinemias	1.4%
436	Fanconi Anemia	1.4%
437	Nesidioblastosis	1.4%
438	Denys-Drash Syndrome	1.4%
439	Lafora Disease	1.4%
440	Unverricht-Lundborg Syndrome	1.4%
441	Anemia, Diamond-Blackfan	1.4%
442	Canavan Disease	1.3%
443	Alexander Disease	1.3%
444	Glycogen storage disease type II	1.3%
445	Optic Atrophy, Hereditary, Leber	1.3%
446	Alkaptonuria	1.3%
447	Glycogen Storage Disease	1.3%
448	Hypophosphatasia	1.3%
449	Propionic acidemia	1.3%
450	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
451	Cystinosis	1.3%
452	Hyperphosphaturia	1.3%
453	Multiple Endocrine Neoplasia	1.3%
454	Kearns-Sayre syndrome	1.2%
455	Dermatitis, Atopic	1.2%
456	Mucopolysaccharidosis III	1.2%
457	Homocystinuria	1.1%
458	Leigh Disease	1.1%
459	Kernicterus	1.1%
460	Behcet Syndrome	1.1%
461	Hyaline Membrane Disease	1.1%
462	Hypolipoproteinemias	1.1%
463	Papillon-Lefevre Disease	1.1%
464	Hyperlipidemia, Familial Combined	1.1%
465	Hyperlipoproteinemia Type III	1.1%
466	Gaucher Disease	1%
467	Huntington Disease	1%
468	Glycogen Storage Disease Type I	1%
469	Glycogen Storage Disease Type V	1%
470	Carbamoyl-Phosphate Synthase I Deficiency Disease	1%
471	Lactose Intolerance	0.9%
472	Variegate Porphyria	0.9%
473	Acute intermittent porphyria	0.9%
474	Porphyria Cutanea Tarda	0.9%
475	Hyperhomocysteinemia	0.9%
476	Renal Aminoacidurias	0.9%
477	Fanconi Syndrome	0.9%
478	Pseudohypoaldosteronism	0.9%
479	Liddle Syndrome	0.9%
480	Hyperlipoproteinemia Type IV	0.9%
481	Hyperlipoproteinemia Type V	0.9%
482	Nephroblastoma	0.9%
483	Tay-Sachs Disease	0.8%
484	Niemann-Pick Disease, Type C	0.8%
485	Multiple Endocrine Neoplasia Type 1	0.8%
486	Friedreich Ataxia	0.8%
487	Adenomatous Polyposis Coli	0.8%
488	Renal tubular acidosis	0.8%
489	Hypoalphalipoproteinemias	0.8%
490	Cystinuria	0.7%
491	Glycosuria, Renal	0.6%

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