MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Iron Overload

(UMLS:C0282193)

Definition:: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
UMLS ID:: C0282193
MeSH ID:: D019190

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.565.500

Synonym(s)

Iron Overload

IRON OVERLOAD

Increased storage iron

Iron excess

Iron overload

Iron overload, NOS

excess iron

excesses iron

iron excess

10.

iron overload

11.

iron overload disorder

12.

iron overloading

13.

overload iron

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Deferasirox	FAERS: 80 Canada Vigilance: 3	17233848 20801540	CTD OFFSIDES SIDER Canada Vigilance US FAERS
2	Lenalidomide	FAERS: 10		OFFSIDES SIDER US FAERS
3	Ruxolitinib phosphate	FAERS: 9		US FAERS
4	Deferoxamine	FAERS: 8 Canada Vigilance: 1		Canada Vigilance US FAERS
5	Cyclosporine	FAERS: 6 Canada Vigilance: 2		Canada Vigilance US FAERS
6	Hemin	FAERS: 3		US FAERS
7	eltrombopag	FAERS: 3		US FAERS
8	ferric citrate	FAERS: 3		US FAERS
9	Azacitidine	FAERS: 2		OFFSIDES US FAERS
10	Ferric Oxide, Saccharated	FAERS: 2		US FAERS
11	Imatinib Mesylate	FAERS: 2		US FAERS
12	ferrous gluconate	FAERS: 2		US FAERS
13	ponatinib	FAERS: 2		US FAERS
14	Atorvastatin	FAERS: 1		US FAERS
15	Carbamazepine	FAERS: 1		US FAERS
16	Dabigatran	FAERS: 1		US FAERS
17	Dasatinib	FAERS: 1		US FAERS
18	Deferiprone	FAERS: 1	31542421	CTD US FAERS
19	Doxorubicin	FAERS: 1		US FAERS
20	Everolimus	FAERS: 1		US FAERS
21	Glatiramer Acetate	FAERS: 1		US FAERS
22	Iron citrate	FAERS: 1		US FAERS
23	Norgestrel	FAERS: 1		US FAERS
24	Ribavirin	FAERS: 1		OFFSIDES US FAERS
25	deflazacort	FAERS: 1		US FAERS
26	eltrombopag	FAERS: 1		US FAERS
27	rucaparib	FAERS: 1		US FAERS
28	Acetylcysteine		31542421	CTD
29	Allopurinol			OFFSIDES
30	Atenolol			OFFSIDES
31	Bendroflumethiazide			OFFSIDES
32	Bimatoprost			OFFSIDES
33	Bisacodyl			OFFSIDES
34	Cadmium Chloride		21540277	CTD
35	Calcium Carbonate			OFFSIDES
36	Chlorothiazide			OFFSIDES
37	Colchicine			OFFSIDES
38	Deferoxamine		17233848 20721892	CTD OFFSIDES
39	Fosinopril			OFFSIDES
40	Fructose		21781943	CTD
41	Hydralazine			OFFSIDES
42	Hydroxyurea			OFFSIDES
43	Ibuprofen			OFFSIDES
44	Loxapine			OFFSIDES
45	Magnesium			OFFSIDES
46	Mercaptopurine			OFFSIDES
47	Metolazone			OFFSIDES
48	Nicardipine			OFFSIDES
49	Orphenadrine			OFFSIDES
50	Penicillin V			OFFSIDES
51	Primidone			OFFSIDES
52	Quinidine			OFFSIDES
53	Raloxifene Hydrochloride			OFFSIDES
54	Rilmenidine			OFFSIDES
55	Sotalol			OFFSIDES
56	Theophylline			OFFSIDES
57	Timolol			OFFSIDES
58	Valganciclovir			OFFSIDES
59	Vancomycin			OFFSIDES
60	alfacalcidol			OFFSIDES
61	calcium acetate			OFFSIDES
62	chlorhexidine gluconate			OFFSIDES
63	mangiferin		18243014	CTD
64	phenylhydrazine		30626086	CTD
65	posaconazole			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Acid-Base Imbalance	31%
2	Calcium Metabolism Disorders	31%
3	Phosphorus Metabolism Disorders	31%
4	Water-Electrolyte Imbalance	31%
5	Lipid Metabolism Disorders	31%
6	Mitochondrial Diseases	31%
7	Glucose Metabolism Disorders	31%
8	Wasting Syndrome	27.9%
9	Hypercalcemia	26.7%
10	Hypocalcemia	26.7%
11	Milk-Alkali Syndrome	26.7%
12	Osteopenia	20.9%
13	Brain Diseases, Metabolic	20.5%
14	Acidosis	20%
15	Alkalosis	20%
16	Amyloidosis	20%
17	Calcinosis	20%
18	Hyperglycemia	20%
19	Hyperinsulinism	20%
20	Hyperkalemia	20%
21	Hypernatremia	20%
22	Hypoglycemia	20%
23	Hypokalemia	20%
24	Hyponatremia	20%
25	Lipodystrophy	20%
26	Xanthomatosis	20%
27	Hypophosphatemia	20%
28	Metabolic acidosis	20%
29	Dyslipidemias	20%
30	Xanthoma	20%
31	Nutrition Disorders	18.5%
32	Pseudohypoparathyroidism	18.1%
33	Rickets	17.3%
34	Brain Diseases, Metabolic, Inborn	15.9%
35	Leigh Disease	15.2%
36	Hyperhomocysteinemia	15.1%
37	Acidosis, Lactic	14.8%
38	Calciphylaxis	14.8%
39	Ketosis	14.8%
40	Ketonuria	14.8%
41	Ketoacidosis	14.8%
42	Ketonemia	14.8%
43	Vascular calcification	14.8%
44	Hypolipoproteinemias	14.6%
45	Hyperlipoproteinemia Type IV	14.5%
46	Hyperlipoproteinemia Type V	14.5%
47	Diabetes Mellitus	14.3%
48	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
49	Lactose Intolerance	13.7%
50	Dehydration	13.6%
51	Lipomatosis	13.6%
52	Water Intoxication	13.6%
53	Werner Syndrome	13.6%
54	Diabetic Ketoacidosis	13.5%
55	Hyperlipidemia, Familial Combined	13.4%
56	Achlorhydria	13.3%
57	Amino Acid Metabolism, Inborn Errors	13.3%
58	Bloom Syndrome	13.3%
59	Carbohydrate Metabolism, Inborn Errors	13.3%
60	Metal Metabolism, Inborn Errors	13.3%
61	Osteoporosis	13.3%
62	Progeria	13.3%
63	Lysosomal Storage Diseases	13.3%
64	Bone Demineralization, Pathologic	13.3%
65	Cytochrome-c Oxidase Deficiency	13.3%
66	Peroxisomal Disorders	13.3%
67	Post-Traumatic Osteoporosis	13.3%
68	Celiac Disease	13.2%
69	Sprue, Tropical	13.2%
70	Steatorrhea	13.2%
71	Sprue	13.2%
72	Osteomalacia	13%
73	Hyperlipoproteinemia Type III	12.7%
74	Smith-Lemli-Opitz Syndrome	12.6%
75	Galactosemias	12.5%
76	Urea Cycle Disorders, Inborn	12.5%
77	Tyrosinemias	12.5%
78	Hypercholesterolemia	12.2%
79	Hyperlipoproteinemias	12.2%
80	Hypertriglyceridemia	12.2%
81	Congenital Hyperinsulinism	12.2%
82	Hypoalphalipoproteinemias	12%
83	Familial Hypophosphatemic Rickets	11.5%
84	Mitochondrial Encephalomyopathies	11.5%
85	Gaucher Disease	10.9%
86	Hyperphosphaturia	10.9%
87	Glycogen storage disease type II	10.6%
88	Homocystinuria	10.4%
89	Child Nutrition Disorders	10.3%
90	Hypervitaminosis A	10.3%
91	Infant Nutrition Disorders	10.3%
92	Malnutrition	10.3%
93	Mitochondrial Myopathies	10.2%
94	Myelinolysis, Central Pontine	10.1%
95	Glycosuria	9.9%
96	Reye Syndrome	9.9%
97	Acidosis, Respiratory	9.9%
98	Adiposis Dolorosa	9.9%
99	Alkalosis, Respiratory	9.9%
100	Hepatic Encephalopathy	9.8%
101	Tay-Sachs Disease	9.8%
102	Nesidioblastosis	9.8%
103	Alkaptonuria	9.8%
104	Glycogen Storage Disease	9.8%
105	Hypophosphatasia	9.8%
106	Insulin Resistance	9.8%
107	Osteoporosis, Postmenopausal	9.8%
108	Propionic acidemia	9.8%
109	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
110	Cystinosis	9.8%
111	Amyloid Neuropathies, Familial	9.8%
112	Renal tubular acidosis	9.7%
113	Niemann-Pick Disease, Type C	9.3%
114	Neuronal Ceroid-Lipofuscinoses	9%
115	HIV Wasting Syndrome	8.8%
116	Fabry Disease	8.5%
117	HIV-Associated Lipodystrophy Syndrome	8.4%
118	MELAS Syndrome	8.2%
119	Renal Osteodystrophy	8.2%
120	Renal rickets	8.2%
121	Porphyrias, Hepatic	8.1%
122	Glycogen Storage Disease Type I	8.1%
123	Glycogen Storage Disease Type V	8.1%
124	Zellweger Syndrome	8%
125	Mucopolysaccharidosis III	8%
126	Adrenoleukodystrophy	8%
127	Necrobiosis Lipoidica Diabeticorum	7.9%
128	Menkes Kinky Hair Syndrome	7.9%
129	Fanconi Anemia	7.8%
130	Wernicke Encephalopathy	7.7%
131	Gestational Diabetes	7.7%
132	Latent Autoimmune Diabetes in Adults	7.7%
133	Diabetes Mellitus, Experimental	7.6%
134	Hepatolenticular Degeneration	7.4%
135	Nephrocalcinosis	7.4%
136	Tetany	7.4%
137	Refsum Disease	7.3%
138	Glycosuria, Renal	7.3%
139	Cerebral Amyloid Angiopathy	7.2%
140	Deficiency Diseases	6.7%
141	Starvation	6.7%
142	Refeeding Syndrome	6.7%
143	Friedreich Ataxia	6.5%
144	Familial Periodic Paralysis	6%
145	Primary amyloidosis	6%
146	Variegate Porphyria	5.9%
147	Acute intermittent porphyria	5.9%
148	Porphyria Cutanea Tarda	5.9%
149	Renal Aminoacidurias	5.8%
150	Fanconi Syndrome	5.8%
151	Pseudohypoaldosteronism	5.8%
152	Liddle Syndrome	5.8%
153	Kernicterus	5.7%
154	Kearns-Sayre syndrome	5.7%
155	Cockayne Syndrome	5.7%
156	Canavan Disease	5.4%
157	Alexander Disease	5.4%
158	Sjogren-Larsson Syndrome	5.4%
159	Mucopolysaccharidosis II	5.3%
160	Ataxia Telangiectasia	5.1%
161	Gout	5%
162	Amyotrophic Lateral Sclerosis	5%
163	Kwashiorkor	4.9%
164	Magnesium Deficiency	4.9%
165	Potassium Deficiency	4.9%
166	Protein Deficiency	4.9%
167	Avitaminosis	4.9%
168	Optic Atrophy, Hereditary, Leber	4.9%
169	Antley-Bixler Syndrome Phenotype	4.9%
170	Hypokalemic periodic paralysis	4.9%
171	Frontotemporal dementia	4.8%
172	Cystinuria	4.8%
173	Xeroderma Pigmentosum	4.5%
174	CREST Syndrome	4.2%
175	Ascorbic Acid Deficiency	4.1%
176	Vitamin A Deficiency	4.1%
177	Vitamin D Deficiency	4.1%
178	Vitamin E Deficiency	4.1%
179	Marasmus	4.1%
180	Arthritis, Gouty	4.1%
181	Albinism	3.7%
182	Folic Acid Deficiency	3.6%
183	Pellagra	3.6%
184	Thiamine Deficiency	3.6%
185	Vitamin B 12 Deficiency	3.6%
186	Vitamin B 6 Deficiency	3.6%
187	Pyridoxine Deficiency	3.6%
188	Beriberi	3.4%
189	Ichthyosis, X-Linked	3%
190	Obesity	2.6%
191	Obesity, Abdominal	2.4%
192	Anemia, Pernicious	2.3%
193	Vitamin K Deficiency	2.1%
194	Pediatric Obesity	1.9%
195	Scurvy	1.8%
196	Prader-Willi Syndrome	1.6%
197	Subacute Combined Degeneration	1.2%

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