MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Varicocele

(UMLS:C0042341)

Definition:: A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
UMLS ID:: C0042341
MeSH ID:: D014646

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.936

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.903

Synonym(s)

Varicocele

Scrotal varices

Scrotal varices - varicocele

VARICOCELE

Vaginal varicocele

Varicocoele

Varicose veins;scrotum

scrotal varices

scrotal varicocele

10.

scrotal varicose veins

11.

scrotum varicose vein

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 59		US FAERS
2	Isotretinoin	FAERS: 27		US FAERS
3	Carbamazepine	FAERS: 4		US FAERS
4	Sildenafil Citrate	FAERS: 3		US FAERS
5	temsirolimus	FAERS: 3		US FAERS
6	Minocycline	FAERS: 2		US FAERS
7	Tenofovir	FAERS: 2		US FAERS
8	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
9	Cinacalcet	FAERS: 1		US FAERS
10	Ciprofloxacin	FAERS: 1		US FAERS
11	Fingolimod Hydrochloride	FAERS: 1		US FAERS
12	Methylphenidate	FAERS: 1		US FAERS
13	Risperidone	FAERS: 1		US FAERS
14	Sertraline	FAERS: 1		US FAERS
15	Sitagliptin Phosphate	FAERS: 1		US FAERS
16	Sunitinib	FAERS: 1		US FAERS
17	Tadalafil	FAERS: 1		US FAERS
18	Testosterone	FAERS: 1	17683466	CTD SIDER US FAERS
19	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
20	Zoledronic Acid	FAERS: 1		US FAERS
21	gadodiamide	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
22	Diethylstilbestrol		7463583	CTD
23	Nitric Oxide		18572859	CTD
24	Silymarin		23659554	CTD
25	Urofollitropin			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Aortic Aneurysm	31%
2	Aortitis	31%
3	Leriche Syndrome	31%
4	Periphlebitis	31%
5	Phlebitis	31%
6	Thromboangiitis Obliterans	31%
7	Thrombophlebitis	29.1%
8	Aneurysm	28.6%
9	Angiomatosis	28.6%
10	Aortic Diseases	28.6%
11	Arterial Occlusive Diseases	28.6%
12	Epididymitis	28.6%
13	Hyperemia	28.6%
14	Hypotension	28.6%
15	Penile Diseases	28.6%
16	Prostatic Diseases	28.6%
17	Spermatic Cord Torsion	28.6%
18	Superior Vena Cava Syndrome	28.6%
19	Telangiectasis	28.6%
20	Vasculitis	28.6%
21	Venous Insufficiency	28.6%
22	Peripheral Vascular Diseases	28.6%
23	Embolism and Thrombosis	28.6%
24	Angiodysplasia	28.6%
25	Hemospermia	28.6%
26	Myocardial Ischemia	28.6%
27	Capillary Leak Syndrome	28.6%
28	Prehypertension	28.6%
29	Testicular Hydrocele	28.6%
30	Postphlebitic Syndrome	28.2%
31	Retinal Vein Occlusion	26.1%
32	Blue Toe Syndrome	26.1%
33	Coronary Aneurysm	25.7%
34	Aortic Rupture	25.4%
35	Aortic Aneurysm, Abdominal	25.4%
36	Aortic Aneurysm, Thoracic	25.4%
37	Malignant Atrophic Papulosis	24.7%
38	Shwartzman Phenomenon	24.5%
39	Carotid Artery Thrombosis	24%
40	Penile Neoplasms	23.7%
41	Prostatic Neoplasms	23.7%
42	Coronary Thrombosis	23.5%
43	Coronary Artery Disease	23.5%
44	Myocardial Reperfusion Injury	23.2%
45	Genital Neoplasms, Male	22.5%
46	Intracranial Embolism and Thrombosis	22.3%
47	Carotid Stenosis	22.2%
48	Intracranial Aneurysm	22.2%
49	Vascular System Injuries	22.2%
50	Moyamoya Disease	22%
51	Compartment syndromes	21.4%
52	Hepatic Veno-Occlusive Disease	21.4%
53	Peliosis Hepatis	21.4%
54	Testicular Diseases	21.4%
55	Cerebrovascular Disorders	21.1%
56	Diabetic Angiopathies	21.1%
57	Infertility	21.1%
58	Reperfusion Injury	21.1%
59	Spermatocele	21.1%
60	Splenic Infarction	21.1%
61	Cerebrovascular Insufficiency	21.1%
62	Vascular Neoplasms	21.1%
63	Spinal Cord Vascular Diseases	21.1%
64	Vasoplegia	21.1%
65	Aneurysm, Dissecting	20.9%
66	Arteriosclerosis	20.9%
67	Arteritis	20.9%
68	Balanitis	20.9%
69	Benign prostatic hypertrophy	20.9%
70	Embolism	20.9%
71	Erythromelalgia	20.9%
72	Fibromuscular Dysplasia	20.9%
73	Malignant Hypertension	20.9%
74	Phimosis	20.9%
75	Priapism	20.9%
76	prostatitis	20.9%
77	Raynaud Disease	20.9%
78	Thromboembolism	20.9%
79	Thrombosis	20.9%
80	Essential Hypertension	20.9%
81	Aneurysm, Ruptured	20.9%
82	Iliac Aneurysm	20.9%
83	Pulmonary artery stenosis	20.9%
84	White Coat Hypertension	20.9%
85	Systemic Vasculitis	20.9%
86	Prostatic Adenoma	20.9%
87	Embolus	20.9%
88	Benign Prostatic Hyperplasia	20.9%
89	Prostatic Hypertrophy	20.9%
90	Prostatic Hyperplasia	20.9%
91	Hemorrhoids	20.9%
92	Thoracic Outlet Syndrome	20.9%
93	Coronary heart disease	20.7%
94	Myocardial Infarction	20.7%
95	Acute Coronary Syndrome	20.7%
96	Polyarteritis Nodosa	20.3%
97	Takayasu Arteritis	20.3%
98	Intracranial Arteriosclerosis	20.1%
99	Cerebral Atherosclerosis	20.1%
100	Cerebral Arteriosclerosis	20.1%
101	Prostatic Neoplasms, Castration-Resistant	19.4%
102	Arteriovenous fistula	19.1%
103	Cerebral Thrombosis	19%
104	Intracranial Embolism	19%
105	Intracranial Thrombosis	19%
106	Vasculitis, Central Nervous System	17.6%
107	Hand-Arm Vibration Syndrome	17.4%
108	Sinus Thrombosis, Intracranial	17.4%
109	Arteriosclerosis Obliterans	17.2%
110	Atherosclerosis	17.2%
111	Azoospermia	17.2%
112	Air Embolism	17.2%
113	Endarteritis	17.2%
114	Oligospermia	17.2%
115	Venous Thrombosis	17.2%
116	Deep Vein Thrombosis	17.2%
117	Impotence, Vasculogenic	17.2%
118	Asthenozoospermia	17.2%
119	Teratozoospermia	17.2%
120	Aspermia	17.2%
121	Venous Thromboembolism	17.2%
122	Coronary Occlusion	16.9%
123	Microvascular Angina	16.9%
124	Coronary Stenosis	16.9%
125	ST segment elevation myocardial infarction	16.9%
126	Optic Neuropathy, Ischemic	16.9%
127	Anterior Ischemic Optic Neuropathy	16.9%
128	Mesenteric vascular insufficiency	16.9%
129	Lemierre Syndrome	16.7%
130	Kounis Syndrome	16.7%
131	Cavernous Sinus Thrombosis	16.6%
132	Sagittal Sinus Thrombosis	16.6%
133	Giant Cell Arteritis	16.6%
134	Brain Infarction	16.6%
135	Temporal Arteritis	16.6%
136	Angioedema	16.4%
137	Colitis, Ischemic	16.4%
138	Renal hypertension	16.3%
139	Renal Artery Obstruction	16.3%
140	Renal Artery Stenosis	16.3%
141	May-Thurner Syndrome	16.3%
142	Angina Pectoris	16.3%
143	Embolism, Amniotic Fluid	15.9%
144	Infarction, Middle Cerebral Artery	15.8%
145	Infarction, Anterior Cerebral Artery	15.8%
146	Infarction, Posterior Cerebral Artery	15.8%
147	Premature Ejaculation	15.8%
148	Retinal Artery Occlusion	15.8%
149	Retinal Vasculitis	15.8%
150	Hypertensive Retinopathy	15.8%
151	Erectile dysfunction	15.8%
152	Anterior Compartment Syndrome	15.5%
153	Orchitis	15.5%
154	Vasculitis, Leukocytoclastic, Cutaneous	15.5%
155	Gastric Antral Vascular Ectasia	15.5%
156	Abdominal Compartment Syndrome	15.5%
157	Carotid Artery Diseases	15.4%
158	Brain Ischemia	15.4%
159	Hypotension, Orthostatic	15.4%
160	Cerebrovascular accident	15.4%
161	Varicose Ulcer	15.4%
162	Vasospasm, Intracranial	15.4%
163	Spinal Cord Ischemia	15.4%
164	Intracranial Arterial Diseases	15.4%
165	Primary Graft Dysfunction	15.4%
166	Post-Exercise Hypotension	15.4%
167	Subarachnoid Hemorrhage, Traumatic	15.2%
168	Carotid Artery, Internal, Dissection	15.2%
169	Coronary Restenosis	15.1%
170	Heart Diseases	15%
171	Cryptorchidism	14.9%
172	Hypospadias	14.9%
173	Cerebral Infarction	14.8%
174	Brain Stem Infarctions	14.8%
175	Sexually Transmitted Diseases	14.5%
176	Vertebral Artery Dissection	14.3%
177	Lateral Medullary Syndrome	13.9%
178	Genital Herpes	13.7%
179	CREST Syndrome	13.7%
180	Shock, Cardiogenic	13.5%
181	Hypertension, Renovascular	13.4%
182	Angina, Unstable	13.4%
183	Intermittent Claudication	13%
184	Pulmonary Embolism	13%
185	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	13%
186	Scimitar Syndrome	13%
187	No-Reflow Phenomenon	12.8%
188	Cerebral Arterial Diseases	12.7%
189	Vertebrobasilar Insufficiency	12.7%
190	Anterior Spinal Artery Syndrome	12.7%
191	Basilar Artery Stenosis	12.7%
192	Vertebral Artery Stenosis	12.7%
193	Intracranial Hemorrhage, Hypertensive	12.7%
194	Transient Cerebral Ischemia	12.7%
195	Mesenteric Vascular Occlusion	12.5%
196	Mucocutaneous Lymph Node Syndrome	12.5%
197	Carotid Artery Injuries	12.4%
198	Diabetic Retinopathy	12.4%
199	Sturge-Weber Syndrome	12.4%
200	Dyspareunia	12.4%
201	Livedo Reticularis	12.3%
202	Hemangioma, Cavernous	12.2%
203	Basal Ganglia Cerebrovascular Disease	12.2%
204	Vascular Headaches	12.1%
205	Scurvy	12.1%
206	Angina Pectoris, Variant	11.9%
207	Hepatic Vein Thrombosis	11.7%
208	Budd-Chiari Syndrome	11.7%
209	Basal Ganglia Hemorrhage	11.6%
210	Pulmonary Infarction	11.5%
211	Subclavian Steal Syndrome	11.3%
212	Pregnancy Complications, Cardiovascular	11.1%
213	Urologic Diseases	11.1%
214	Cardiovascular Abnormalities	11.1%
215	Putaminal Hemorrhage	10.7%
216	Aortic Valve Stenosis	10.3%
217	Cardiomyopathy, Dilated	10.3%
218	Pulmonary Valve Stenosis	10.3%
219	Ischemic contracture	10.2%
220	Testicular Neoplasms	10.2%
221	Angioedemas, Hereditary	10.2%
222	Tricuspid Atresia	10.2%
223	Arrhythmogenic Right Ventricular Dysplasia	10.2%
224	Cryoglobulinemia	10.1%
225	Leukomalacia, Periventricular	10.1%
226	Subarachnoid Hemorrhage	10%
227	Hypoxia-Ischemia, Brain	10%
228	Cerebral Hemorrhage	10%
229	Diabetic Foot	10%
230	Hereditary Angioedema Type III	10%
231	Hereditary Angioedema Types I and II	10%
232	Dementia, Vascular	9.9%
233	Cardiac Tamponade	9.5%
234	Endocarditis	9.5%
235	Cardiac Arrest	9.5%
236	Heart failure	9.5%
237	Pericardial effusion	9.5%
238	Pericarditis	9.5%
239	Pneumopericardium	9.5%
240	Cor pulmonale	9.5%
241	Ventricular Outflow Obstruction	9.5%
242	Ventricular Dysfunction	9.5%
243	Cardiomyopathies	9.5%
244	Pleuropericarditis	9.5%
245	Granulomatosis with polyangiitis	9.2%
246	Cerebral Amyloid Angiopathy	9%
247	Hypertrophic Cardiomyopathy	8.9%
248	Hypertrophic obstructive cardiomyopathy	8.9%
249	Urogenital Abnormalities	8.8%
250	Shy-Drager Syndrome	8.6%
251	Purpura, Hyperglobulinemic	8.6%
252	Supravalvular aortic stenosis	8.5%
253	Lown-Ganong-Levine Syndrome	8.5%
254	Pituitary Apoplexy	8.4%
255	Heart Block	8.2%
256	Tachycardia	8.2%
257	Tachyarrhythmia	8.2%
258	Aortic coarctation	8.2%
259	Cor Triatriatum	8.2%
260	Coronary Vessel Anomalies	8.2%
261	Patent ductus arteriosus	8.2%
262	Ebstein Anomaly	8.2%
263	Heart Septal Defects	8.2%
264	Tetralogy of Fallot	8.2%
265	Transposition of Great Vessels	8.2%
266	Hypoplastic Left Heart Syndrome	8.2%
267	Bacterial Endocarditis	8.1%
268	Behcet Syndrome	7.6%
269	Lupus Vasculitis, Central Nervous System	7.6%
270	Waldenstrom Macroglobulinemia	7.6%
271	Multiple Myeloma	7.6%
272	Rheumatoid Vasculitis	7.2%
273	Cardiac Output, High	7.1%
274	Myocardial Stunning	7.1%
275	Low Cardiac Output Syndrome	7.1%
276	Chlamydia Infections	7.1%
277	Gonorrhea	7.1%
278	Sick Sinus Syndrome	7.1%
279	Urinary Bladder Diseases	7%
280	Cardiomegaly	7%
281	Kidney Diseases	7%
282	Postpericardiotomy Syndrome	7%
283	Ureteral Diseases	7%
284	Urethral Diseases	7%
285	Urination Disorders	7%
286	Urolithiasis	7%
287	Cardiac Hypertrophy	7%
288	Aortic Valve Insufficiency	7%
289	Restrictive cardiomyopathy	7%
290	Endocardial Fibroelastosis	7%
291	Heart Rupture, Post-Infarction	7%
292	Mitral Valve Insufficiency	7%
293	Mitral Valve Stenosis	7%
294	Myocarditis	7%
295	Pericarditis, Constrictive	7%
296	Pulmonary Valve Insufficiency	7%
297	Tricuspid Valve Insufficiency	7%
298	Tricuspid Valve Stenosis	7%
299	Ventricular Dysfunction, Left	7%
300	Right Ventricular Dysfunction	7%
301	Endomyocardial Fibrosis	7%
302	Carditis	7%
303	Heart Failure, Systolic	7%
304	Heart Failure, Diastolic	7%
305	Rheumatic Heart Disease	6.9%
306	Ataxia Telangiectasia	6.8%
307	Bladder Exstrophy	6.8%
308	Epispadias	6.8%
309	Pseudoxanthoma Elasticum	6.8%
310	Dextrocardia	6.8%
311	Long QT Syndrome	6.8%
312	Tuberculosis, Renal	6.8%
313	Anuria	6.7%
314	Ureterolithiasis	6.7%
315	Nephrolithiasis	6.7%
316	Adams-Stokes Syndrome	6.7%
317	Atrioventricular Block	6.7%
318	Bundle-Branch Block	6.7%
319	Atrial Premature Complexes	6.7%
320	Sinoatrial Block	6.7%
321	Tachycardia, Paroxysmal	6.7%
322	Supraventricular tachycardia	6.7%
323	Tachycardia, Ventricular	6.7%
324	Wolff-Parkinson-White Syndrome	6.7%
325	Tachycardia, Reciprocating	6.7%
326	Aortopulmonary Septal Defect	6.7%
327	Double Outlet Right Ventricle	6.7%
328	Endocardial Cushion Defects	6.7%
329	Myocardial bridging	6.7%
330	Aorticopulmonary Septal Defect	6.7%
331	Leydig Cell Tumor	6.5%
332	Lymphogranuloma Venereum	6.3%
333	Multicystic Dysplastic Kidney	6.3%
334	Syphilis	6.2%
335	Bladder neck obstruction	6.1%
336	Tachycardia, Atrioventricular Nodal Reentry	6%
337	Tachycardia, Ectopic Atrial	6%
338	Tachycardia, Ectopic Junctional	6%
339	Sinus Tachycardia	6%
340	Torsades de Pointes	6%
341	Accelerated Idioventricular Rhythm	6%
342	Truncus Arteriosus, Persistent	6%
343	Aortic Valve Prolapse	5.7%
344	Tricuspid Valve Prolapse	5.7%
345	Takotsubo Cardiomyopathy	5.7%
346	Urinary Bladder Fistula	5.7%
347	Bladder Neoplasm	5.7%
348	Kidney Neoplasm	5.7%
349	Ureteral Neoplasms	5.7%
350	Urethral Neoplasms	5.7%
351	Urinary tract infection	5.6%
352	Urologic Neoplasms	5.6%
353	Horseshoe Kidney	5.6%
354	Hematoma, Subdural	5.5%
355	Hematoma, Epidural, Cranial	5.5%
356	Romano-Ward Syndrome	5.5%
357	Kidney Calculi	5.5%
358	Ureteral Calculi	5.5%
359	Subacute Bacterial Endocarditis	5.3%
360	Pyelocystitis	5.2%
361	Hematoma, Subdural, Intracranial	5.2%
362	Hematoma, Subdural, Chronic	5.2%
363	Hematoma, Subdural, Acute	5.2%
364	Sinus Arrhythmia	5.2%
365	Atrial Fibrillation	5.2%
366	Atrial Flutter	5.2%
367	Edema, Cardiac	5.2%
368	Ventricular Fibrillation	5.2%
369	Ventricular Flutter	5.2%
370	Parasystole	5.2%
371	Paroxysmal atrial fibrillation	5.2%
372	Bradycardia	5.2%
373	Diabetic Cardiomyopathies	5.2%
374	Cardiomyopathy, Alcoholic	5.1%
375	Cystitis	5.1%
376	Ectopia Cordis	5.1%
377	Hydronephrosis	5.1%
378	Hyperoxaluria	5.1%
379	Kidney Cortex Necrosis	5.1%
380	Kidney Papillary Necrosis	5.1%
381	Nephritis	5.1%
382	Nephrosclerosis	5.1%
383	Nephrosis	5.1%
384	Perinephritis	5.1%
385	Kidney Failure	5.1%
386	Uremia	5.1%
387	Ureteral obstruction	5.1%
388	Ureterocele	5.1%
389	Urethral Obstruction	5.1%
390	Urethritis	5.1%
391	Vesico-Ureteral Reflux	5.1%
392	Urinary Retention	5.1%
393	Sudden Cardiac Death	5.1%
394	Left Ventricular Hypertrophy	5.1%
395	Right Ventricular Hypertrophy	5.1%
396	Oxalosis	5.1%
397	Single umbilical artery	5.1%
398	Renal Insufficiency	5.1%
399	Chagas Cardiomyopathy	5.1%
400	Noonan Syndrome	5.1%
401	Pyelonephritis	4.9%
402	Brain Hemorrhage, Traumatic	4.9%
403	Turner Syndrome	4.8%
404	Hermaphroditism	4.7%
405	Disorders of Sex Development	4.7%
406	Marfan Syndrome	4.6%
407	Carcinoid Heart Disease	4.5%
408	MELAS Syndrome	4.5%
409	Sinus Arrest, Cardiac	4.2%
410	Glomerulonephritis	4.2%
411	Nephritis, Interstitial	4.2%
412	Lipoid nephrosis	4.2%
413	Nephrotic Syndrome	4.2%
414	Pyelitis	4.2%
415	Pyonephrosis	4.2%
416	Urethral Stenosis	4.2%
417	Nephrogenic Diabetes Insipidus	4.2%
418	Congenital Nephrogenic Diabetes Insipidus	4.2%
419	Acute kidney injury	4.2%
420	Urethral stricture	4.2%
421	Diabetes Insipidus	4.1%
422	Hepatorenal Syndrome	4.1%
423	Mesoblastic Nephroma	4.1%
424	Renal Cell Carcinoma	4.1%
425	Papillary Renal Cell Carcinoma	4.1%
426	Bacteriuria	4.1%
427	Diabetic Nephropathy	4.1%
428	Dyspnea, Paroxysmal	4.1%
429	Glycosuria	4.1%
430	Hematuria	4.1%
431	Oliguria	4.1%
432	Polyuria	4.1%
433	Proteinuria	4.1%
434	Pyuria	4.1%
435	Urinary Calculi	4.1%
436	Cystocele	4.1%
437	Nephrocalcinosis	4.1%
438	Urinary Incontinence	4.1%
439	Balkan Nephropathy	3.8%
440	Focal glomerulosclerosis	3.8%
441	Kidney Failure, Chronic	3.8%
442	Glycosuria, Renal	3.6%
443	Fabry Disease	3.5%
444	Enuresis	3.4%
445	Dural Arteriovenous Fistula	3.4%
446	Azotemia	3.4%
447	Gonadal Dysgenesis	3.4%
448	Adrenogenital Syndrome	3.4%
449	Ovotesticular Disorders of Sex Development	3.4%
450	Albuminuria	3.3%
451	Hemoglobinuria	3.3%
452	Urge Incontinence	3.3%
453	Nephroblastoma	3.3%
454	Hyperandrogenism	3.3%
455	Denys-Drash Syndrome	3.2%
456	Glomerulonephritis, Membranoproliferative	3.1%
457	AIDS-Associated Nephropathy	2.9%
458	Polycystic Kidney Diseases	2.8%
459	Diurnal Enuresis	2.8%
460	Renal Aminoacidurias	2.8%
461	Fanconi Syndrome	2.8%
462	Pseudohypoaldosteronism	2.8%
463	Liddle Syndrome	2.8%
464	Hemolytic-Uremic Syndrome	2.8%
465	Anti-Glomerular Basement Membrane Disease	2.5%
466	Williams Syndrome	2.5%
467	Lupus Nephritis	2.5%
468	Polycystic Kidney, Autosomal Dominant	2.5%
469	Cystinuria	2.5%
470	Atypical Hemolytic Uremic Syndrome	2.5%
471	Kartagener Syndrome	2.4%
472	Renal tubular acidosis	2.4%
473	Renal Osteodystrophy	2.2%
474	Renal rickets	2.2%
475	Kallmann Syndrome	2.1%
476	Hyperphosphaturia	1.8%
477	Klinefelter Syndrome	1.8%
478	Zellweger Syndrome	1.7%
479	Kearns-Sayre syndrome	1.6%
480	Familial Hypophosphatemic Rickets	1%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234