MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Reye Syndrome

(UMLS:C0035400)

Definition:: A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
UMLS ID:: C0035400
MeSH ID:: D012202

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.241.649

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.780

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.780

Synonym(s)

Reye Syndrome

FATTY LIVER WITH ENCEPHALOPATHY

REYE SYNDROME

REYE'S SYNDROME

Reye syndrome

Reye's Syndrome

Reye's encephalopathy

Reye's syndrome

Reyes' syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	4-pentenoic acid	28452736	CTD
2	Aspirin	View details 1972225 2739536 2901540 2903294 3392791 3415311 3670965 3752019 3820509 3948691 4022693 4036917 4684381 6694278 8388687 8669954 8890094 11431304 11436370 11470397 12602712 14662583 15157377 16388216 19149521 20167009	CTD
3	Carnitine	28452736	CTD
4	Diclofenac	9379106 9742877	CTD
5	Valproic Acid	6819143	CTD
6	corvitin	28452736	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hepatic Encephalopathy	36.6%
2	Myelinolysis, Central Pontine	35%
3	Brain Diseases, Metabolic, Inborn	33%
4	Mitochondrial Encephalomyopathies	28.3%
5	Hepatolenticular Degeneration	24.7%
6	Wernicke Encephalopathy	24.7%
7	Leigh Disease	23.3%
8	Marchiafava-Bignami Disease	23.3%
9	Non-alcoholic Fatty Liver Disease	23.1%
10	Galactosemias	22.2%
11	Urea Cycle Disorders, Inborn	22.2%
12	Tyrosinemias	22.2%
13	Fatty Liver, Alcoholic	21.9%
14	Kernicterus	21.5%
15	Adrenoleukodystrophy	20.4%
16	Carbamoyl-Phosphate Synthase I Deficiency Disease	20.4%
17	Zellweger Syndrome	20.1%
18	Homocystinuria	19.6%
19	MELAS Syndrome	19.4%
20	Meningoencephalitis	17.8%
21	Canavan Disease	17.8%
22	Alexander Disease	17.8%
23	Subdural Effusion	17.8%
24	Akinetic Mutism	17.4%
25	Anoxic Encephalopathy	17.4%
26	Basal Ganglia Diseases	17.4%
27	Brain Damage, Chronic	17.4%
28	Cerebellar Diseases	17.4%
29	Encephalitis	17.4%
30	Encephalomalacia	17.4%
31	Epilepsy	17.4%
32	Hydrocephalus	17.4%
33	Congenital Hydrocephalus	17.4%
34	Hypothalamic Diseases	17.4%
35	Thalamic Diseases	17.4%
36	Intracranial Hypertension	17.4%
37	Aura	17.4%
38	Leukoencephalopathy	17.4%
39	Neuroaxonal Dystrophies	17.4%
40	Headache Disorders	17.4%
41	Intracranial Hypotension	17.4%
42	Brain Edema	17.4%
43	Brain Hypoxia	17.4%
44	Aqueductal Stenosis	17.4%
45	Glycogen storage disease type II	17.1%
46	Dementia, Vascular	16.4%
47	Wasting Syndrome	16.3%
48	Encephalomyelitis	16.1%
49	Gaucher Disease	16%
50	Posterior Leukoencephalopathy Syndrome	16%
51	Posterior reversible encephalopathy syndrome	16%
52	Hypercalcemia	15.9%
53	Hypocalcemia	15.9%
54	Milk-Alkali Syndrome	15.9%
55	Refsum Disease	15.7%
56	Menkes Kinky Hair Syndrome	15.7%
57	Dandy-Walker Syndrome	15.6%
58	Basal Ganglia Cerebrovascular Disease	15.3%
59	Parkinsonian Disorders	15.1%
60	Acid-Base Imbalance	15.1%
61	Calcium Metabolism Disorders	15.1%
62	Iron Metabolism Disorders	15.1%
63	Hepatitis	15.1%
64	Portal Hypertension	15.1%
65	Liver Cirrhosis	15.1%
66	Phosphorus Metabolism Disorders	15.1%
67	Water-Electrolyte Imbalance	15.1%
68	Lipid Metabolism Disorders	15.1%
69	Focal Nodular Hyperplasia	15.1%
70	Mitochondrial Diseases	15.1%
71	Glucose Metabolism Disorders	15.1%
72	Hepatic Insufficiency	15.1%
73	Fabry Disease	15.1%
74	Multiple System Atrophy	14.8%
75	Lewy Body Disease	14.6%
76	Pneumocephalus	14.6%
77	Biliary cirrhosis	14.5%
78	Tay-Sachs Disease	14.5%
79	Porphyrias, Hepatic	14.4%
80	Brain Abscess	14.3%
81	Cerebrovascular Disorders	14.1%
82	Cerebrovascular Insufficiency	14.1%
83	Dementia	14.1%
84	Epilepsy, Post-Traumatic	14%
85	Niemann-Pick Disease, Type C	13.8%
86	Myoclonic Epilepsy	13.6%
87	Epilepsy, Temporal Lobe	13.6%
88	Epilepsy, Rolandic	13.6%
89	Benign Rolandic Epilepsy	13.6%
90	Pseudohypoparathyroidism	13.6%
91	Liver neoplasms	13.6%
92	Vascular Headaches	13.4%
93	Hypoxia-Ischemia, Brain	13.3%
94	Lipodystrophy	13.3%
95	Brain Injuries	13.3%
96	Brain Neoplasms	13.2%
97	Hepatitis, Alcoholic	13.2%
98	Liver Cirrhosis, Alcoholic	13.2%
99	Leukomalacia, Periventricular	13.1%
100	Meige Syndrome	13.1%
101	Cerebral Ventriculitis	13.1%
102	Meningitis	12.6%
103	Movement Disorders	12.6%
104	Pachymeningitis	12.6%
105	Spinal Cord Diseases	12.6%
106	Liver Diseases, Parasitic	12.6%
107	Friedreich Ataxia	12.4%
108	Rickets	12.3%
109	Hepatic Veno-Occlusive Disease	12.2%
110	Osteopenia	12.2%
111	Peliosis Hepatis	12.2%
112	Hepatopulmonary Syndrome	12.2%
113	Brain Death	12.2%
114	Hepatomegaly	12.1%
115	Cerebellar Neoplasms	12%
116	Hepatic Vein Thrombosis	12%
117	Liver Abscess	12%
118	Budd-Chiari Syndrome	12%
119	Myelitis	11.9%
120	Parkinson Disease	11.8%
121	Ocular Motility Disorders	11.7%
122	Cyclophoria	11.7%
123	Huntington Disease	11.7%
124	Congenital Hyperinsulinism	11.5%
125	Cerebral Palsy	11.5%
126	Epilepsies, Partial	11.5%
127	Epilepsy, Generalized	11.5%
128	Pseudotumor Cerebri	11.5%
129	Hypertensive Encephalopathy	11.5%
130	Simple Partial Seizures	11.5%
131	Epilepsy, Reflex	11.5%
132	Headache Disorders, Primary	11.5%
133	Headache Disorders, Secondary	11.5%
134	Medication overuse headache	11.5%
135	Juvenile Myoclonic Epilepsy	11.3%
136	Myoclonic Epilepsies, Progressive	11.3%
137	Epidural Abscess	11.3%
138	Lactose Intolerance	11.2%
139	Amyotrophic Lateral Sclerosis	11.2%
140	Creutzfeldt-Jakob disease	10.9%
141	Amblyopia	10.9%
142	Hyperhomocysteinemia	10.8%
143	Dystonia Musculorum Deformans	10.8%
144	Basal Ganglia Hemorrhage	10.6%
145	Achlorhydria	10.6%
146	Esophageal and Gastric Varices	10.6%
147	Neuroleptic Malignant Syndrome	10.6%
148	Central Nervous System Infection	10.5%
149	Hyperlipoproteinemia Type IV	10.4%
150	Hyperlipoproteinemia Type V	10.4%
151	Chemical and Drug Induced Liver Injury	10.3%
152	Leukoencephalopathy, Progressive Multifocal	10.2%
153	Striatonigral Degeneration	10%
154	Familial Hypophosphatemic Rickets	10%
155	Hepatorenal Syndrome	10%
156	Liver Abscess, Amebic	10%
157	Acidosis	9.9%
158	Alkalosis	9.9%
159	Amyloidosis	9.9%
160	Calcinosis	9.9%
161	Hepatitis, Chronic	9.9%
162	Hyperglycemia	9.9%
163	Hyperinsulinism	9.9%
164	Hyperkalemia	9.9%
165	Hypernatremia	9.9%
166	Hypoglycemia	9.9%
167	Hypokalemia	9.9%
168	Hyponatremia	9.9%
169	Xanthomatosis	9.9%
170	Liver Failure	9.9%
171	Hypophosphatemia	9.9%
172	Metabolic acidosis	9.9%
173	Dyslipidemias	9.9%
174	Iron Overload	9.9%
175	Xanthoma	9.9%
176	Chronic active hepatitis	9.9%
177	Celiac Disease	9.9%
178	Sprue, Tropical	9.9%
179	Steatorrhea	9.9%
180	Sprue	9.9%
181	Pituitary Apoplexy	9.9%
182	Progressive supranuclear palsy	9.8%
183	Variegate Porphyria	9.8%
184	Acute intermittent porphyria	9.8%
185	Porphyria Cutanea Tarda	9.8%
186	Hypolipoproteinemias	9.8%
187	Smith-Lemli-Opitz Syndrome	9.8%
188	Brain Infarction	9.7%
189	Pituitary Diseases	9.6%
190	Cerebral Amyloid Angiopathy	9.6%
191	Amyloid Neuropathies, Familial	9.4%
192	Limbic Encephalitis	9.4%
193	Lupus Vasculitis, Central Nervous System	9.4%
194	Prion Diseases	9.4%
195	Presenile dementia	9.3%
196	Senile dementia	9.3%
197	Osteomalacia	9.3%
198	Frontotemporal dementia	9.3%
199	Pituitary Adenoma	9.2%
200	Pituitary Neoplasms	9.2%
201	Carotid Artery Diseases	9.2%
202	Brain Ischemia	9.2%
203	Cerebrovascular accident	9.2%
204	Kluver-Bucy Syndrome	9.2%
205	Vasospasm, Intracranial	9.2%
206	Intracranial Arterial Diseases	9.2%
207	Stiff-Person Syndrome	9.2%
208	Amnesia, Transient Global	9.2%
209	Ataxia Telangiectasia	9%
210	Putaminal Hemorrhage	9%
211	Diabetic Ketoacidosis	9%
212	Hyperlipidemia, Familial Combined	8.9%
213	Nesidioblastosis	8.9%
214	Subacute Combined Degeneration	8.8%
215	Shy-Drager Syndrome	8.8%
216	Hyperphosphaturia	8.8%
217	Lafora Disease	8.7%
218	Unverricht-Lundborg Syndrome	8.7%
219	Infarction, Middle Cerebral Artery	8.7%
220	Infarction, Anterior Cerebral Artery	8.7%
221	Infarction, Posterior Cerebral Artery	8.7%
222	Biliary Tract Diseases	8.7%
223	Gastrointestinal Diseases	8.7%
224	Pancreatic Diseases	8.7%
225	Carotid Artery Injuries	8.7%
226	Brain Injuries, Diffuse	8.7%
227	Traumatic Brain Injury	8.7%
228	Nutrition Disorders	8.7%
229	Cerebellar Ataxia	8.7%
230	Supratentorial Neoplasms	8.7%
231	Brain Hemorrhage, Traumatic	8.6%
232	Leukoencephalitis, Acute Hemorrhagic	8.6%
233	MPTP Poisoning	8.6%
234	Post-Traumatic Headache	8.6%
235	Tension Headache	8.6%
236	Epilepsy, Complex Partial	8.6%
237	Migraine Disorders	8.6%
238	Abdominal Migraine	8.6%
239	Status Migrainosus	8.6%
240	Cervicogenic Headache	8.6%
241	Hyperlipoproteinemia Type III	8.5%
242	Mitochondrial Myopathies	8.4%
243	Persistent Vegetative State	8.4%
244	Spinal Muscular Atrophy	8.3%
245	Progressive Muscular Atrophy	8.3%
246	Diabetes Mellitus	8.3%
247	Hepatitis, Animal	8.3%
248	Hepatitis, Viral, Human	8.3%
249	Meningitis, Bacterial	8.2%
250	Meningitis, Fungal	8.2%
251	Spinal Cord Injuries	8.1%
252	Hypoalphalipoproteinemias	8.1%
253	Dehydration	8.1%
254	Lipomatosis	8.1%
255	Water Intoxication	8.1%
256	Werner Syndrome	8.1%
257	Cerebral Infarction	8%
258	Brain Stem Infarctions	8%
259	Poliomyelitis	8%
260	Paraneoplastic Cerebellar Degeneration	8%
261	Toxoplasmosis, Cerebral	8%
262	Neuronal Ceroid-Lipofuscinoses	8%
263	Amino Acid Metabolism, Inborn Errors	7.9%
264	Bloom Syndrome	7.9%
265	Carbohydrate Metabolism, Inborn Errors	7.9%
266	Liver Cirrhosis, Experimental	7.9%
267	Metal Metabolism, Inborn Errors	7.9%
268	Osteoporosis	7.9%
269	Progeria	7.9%
270	Lysosomal Storage Diseases	7.9%
271	Bone Demineralization, Pathologic	7.9%
272	Cytochrome-c Oxidase Deficiency	7.9%
273	Peroxisomal Disorders	7.9%
274	Post-Traumatic Osteoporosis	7.9%
275	Vasculitis, Central Nervous System	7.9%
276	Cranial nerve diseases	7.8%
277	Demyelinating Diseases	7.8%
278	Demyelination	7.8%
279	Neuromuscular Diseases	7.8%
280	Chronobiology Disorders	7.8%
281	Asterixis	7.8%
282	Ballismus	7.8%
283	Moyamoya Disease	7.8%
284	Encephalomyelitis, Acute Disseminated	7.7%
285	Hepatitis B, Chronic	7.7%
286	Hepatitis C, Chronic	7.7%
287	Intracranial Embolism and Thrombosis	7.7%
288	Ophthalmoplegic Migraine	7.5%
289	Hepatocellular Adenoma	7.5%
290	Arachnoiditis	7.4%
291	Aseptic Meningitis	7.4%
292	Syringomyelia	7.4%
293	Essential Tremor	7.4%
294	Familial Tremor	7.4%
295	Pneumorrhachis	7.4%
296	Writer's Cramp	7.4%
297	Acidosis, Lactic	7.4%
298	Calciphylaxis	7.4%
299	Hemosiderosis	7.4%
300	Ketosis	7.4%
301	Ketonuria	7.4%
302	Liver Failure, Acute	7.4%
303	Ketoacidosis	7.4%
304	Ketonemia	7.4%
305	Vascular calcification	7.4%
306	End Stage Liver Disease	7.4%
307	Renal tubular acidosis	7.3%
308	Lateral Medullary Syndrome	7.2%
309	Miller Fisher Syndrome	7.2%
310	Cluster Headache	7.1%
311	Migraine with Aura	7.1%
312	Familial Hemiplegic Migraine	7.1%
313	Chronic Paroxysmal Hemicrania	7.1%
314	SUNCT Syndrome	7.1%
315	Paroxysmal Hemicrania	7.1%
316	Zollinger-Ellison syndrome	7.1%
317	Digestive System Neoplasms	7%
318	Empty Sella Syndrome	7%
319	Hyperpituitarism	7%
320	Hypopituitarism	7%
321	Hypophysitis	7%
322	Chronic Fatigue Syndrome	7%
323	Cerebral Arterial Diseases	6.8%
324	Vertebrobasilar Insufficiency	6.8%
325	Basilar Artery Stenosis	6.8%
326	Vertebral Artery Stenosis	6.8%
327	Intracranial Hemorrhage, Hypertensive	6.8%
328	Transient Cerebral Ischemia	6.8%
329	Motor Neuron Disease	6.8%
330	Gastrointestinal Neoplasms	6.8%
331	Pancreatic Fistula	6.7%
332	Fascioliasis	6.7%
333	Echinococcosis, Hepatic	6.7%
334	Liver Neoplasms, Experimental	6.6%
335	Chemical and Drug Induced Liver Injury, Chronic	6.6%
336	Glycosuria	6.6%
337	Spinal Cord Neoplasms	6.6%
338	HIV Wasting Syndrome	6.6%
339	Tetany	6.6%
340	Renal Osteodystrophy	6.5%
341	Renal rickets	6.5%
342	HIV-Associated Lipodystrophy Syndrome	6.5%
343	Trauma, Nervous System	6.5%
344	Diffuse Axonal Injury	6.5%
345	Brain Stem Neoplasms	6.5%
346	Nervous System Neoplasms	6.3%
347	Neurologic Manifestations	6.3%
348	Neurotoxicity Syndromes	6.3%
349	Subarachnoid Hemorrhage, Traumatic	6.3%
350	Carotid Artery, Internal, Dissection	6.3%
351	Myelitis, Transverse	6.3%
352	Massive Hepatic Necrosis	6.1%
353	Hypercholesterolemia	6.1%
354	Hyperlipoproteinemias	6.1%
355	Hypertriglyceridemia	6.1%
356	Tuberculosis, Meningeal	6.1%
357	Mucopolysaccharidosis III	6%
358	Central Nervous System Fungal Infections	6%
359	Conus Medullaris Syndrome	6%
360	Spinal Cord Vascular Diseases	6%
361	Autoimmune hepatitis	6%
362	Kearns-Sayre syndrome	6%
363	Acidosis, Respiratory	5.9%
364	Adiposis Dolorosa	5.9%
365	Alkalosis, Respiratory	5.9%
366	Restless Legs Syndrome	5.9%
367	Alkaptonuria	5.9%
368	Glycogen Storage Disease	5.9%
369	Hypophosphatasia	5.9%
370	Insulin Resistance	5.9%
371	Osteoporosis, Postmenopausal	5.9%
372	Propionic acidemia	5.9%
373	Dihydropyrimidine Dehydrogenase Deficiency	5.9%
374	Cystinosis	5.9%
375	Akathisia, Drug-Induced	5.9%
376	Subacute Sclerosing Panencephalitis	5.8%
377	Glycosuria, Renal	5.8%
378	Auditory Perceptual Disorders	5.8%
379	Peritoneal Neoplasms	5.8%
380	Polyradiculoneuropathy	5.8%
381	Polyradiculoneuritis	5.8%
382	Hyperprolactinemia	5.7%
383	AIDS Dementia Complex	5.7%
384	Carotid Stenosis	5.7%
385	Intracranial Aneurysm	5.7%
386	Intracranial Arteriosclerosis	5.7%
387	Cerebral Atherosclerosis	5.7%
388	Subarachnoid Hemorrhage	5.7%
389	Cerebral Arteriosclerosis	5.7%
390	Cerebral Hemorrhage	5.7%
391	Familial Periodic Paralysis	5.7%
392	Cerebral Thrombosis	5.7%
393	Intracranial Embolism	5.7%
394	Intracranial Thrombosis	5.7%
395	Subclavian Steal Syndrome	5.7%
396	Pick Disease of the Brain	5.7%
397	Bile Duct Neoplasms	5.7%
398	gallbladder neoplasm	5.7%
399	Intestinal Neoplasms	5.7%
400	Stomach Neoplasms	5.7%
401	Necrobiosis Lipoidica Diabeticorum	5.7%
402	Mesenteric vascular insufficiency	5.6%
403	Opsoclonus-Myoclonus Syndrome	5.6%
404	Fanconi Anemia	5.6%
405	Esophageal Atresia	5.6%
406	Intestinal Atresia	5.6%
407	Mesenteric Vascular Occlusion	5.6%
408	Brain Contusion	5.6%
409	Intestinal Fistula	5.6%
410	Enterocutaneous Fistula	5.6%
411	Vertebral Artery Dissection	5.5%
412	Cockayne Syndrome	5.5%
413	Proctocolitis	5.5%
414	Colorectal Neoplasms	5.4%
415	Autonomic Dysreflexia	5.4%
416	Complex Regional Pain Syndromes	5.4%
417	Choroid Plexus Papilloma	5.4%
418	Sleep Wake Disorders	5.3%
419	Dysentery	5.3%
420	Enteritis	5.3%
421	Enterocolitis	5.3%
422	Esophagitis	5.3%
423	Gastritis	5.3%
424	Inflammatory Bowel Diseases	5.3%
425	Cholecystolithiasis	5.3%
426	Dyskinesia, Drug-Induced	5.2%
427	Hepatitis, Viral, Animal	5.2%
428	Pancreatic Neoplasm	5.1%
429	Central Nervous System Bacterial Infections	5.1%
430	Optic Atrophy, Hereditary, Leber	5.1%
431	Gestational Diabetes	5.1%
432	Hepatitis E	5.1%
433	Latent Autoimmune Diabetes in Adults	5.1%
434	Brain Concussion	5%
435	Bile Duct Diseases	5%
436	Child Nutrition Disorders	5%
437	Cholelithiasis	5%
438	Chylous Ascites	5%
439	Esophageal Diseases	5%
440	Gastroenteritis	5%
441	Hypervitaminosis A	5%
442	Infant Nutrition Disorders	5%
443	Intestinal Diseases	5%
444	Pancreatic Insufficiency	5%
445	Pancreatitis	5%
446	Pneumoperitoneum	5%
447	Stomach Diseases	5%
448	Malnutrition	5%
449	Diabetes Mellitus, Experimental	5%
450	Hepatitis B	5%
451	Hepatitis C	5%
452	Scrapie	5%
453	Central Cord Syndrome	5%
454	Hepatitis A	5%
455	Esophageal Neoplasms	5%
456	Chorea	4.9%
457	Nephrocalcinosis	4.9%
458	Meningitis, Cryptococcal	4.9%
459	Duodenitis	4.9%
460	Ileitis	4.9%
461	Erosive Duodenitis	4.9%
462	Meningitis, Listeria	4.9%
463	Glycogen Storage Disease Type I	4.9%
464	Glycogen Storage Disease Type V	4.9%
465	Cecal Neoplasms	4.9%
466	Duodenal Neoplasms	4.9%
467	Carotid Artery Thrombosis	4.9%
468	Meningitis, Haemophilus	4.9%
469	Meningitis, Pneumococcal	4.9%
470	Mucopolysaccharidosis II	4.8%
471	Choledochal Cyst	4.8%
472	Acromegaly	4.8%
473	Sinus Thrombosis, Intracranial	4.7%
474	Rectal Fistula	4.7%
475	Anal Fistula	4.7%
476	Colitis	4.6%
477	Duodenogastric Reflux	4.6%
478	Peptic Ulcer	4.6%
479	Proctitis	4.6%
480	Choledocholithiasis	4.6%
481	Alice in Wonderland Syndrome	4.6%
482	West Nile Fever	4.5%
483	Peripheral Nerve Injuries	4.5%
484	Sjogren-Larsson Syndrome	4.5%
485	Myasthenia Gravis	4.5%
486	Hypokalemic periodic paralysis	4.4%
487	Giant Cell Arteritis	4.4%
488	Temporal Arteritis	4.4%
489	Gastrointestinal Stromal Tumors	4.4%
490	Torticollis	4.3%
491	Guillain-Barre Syndrome	4.3%
492	Primary amyloidosis	4.2%
493	Cavernous Sinus Thrombosis	4.2%
494	Sagittal Sinus Thrombosis	4.2%
495	Dysautonomia	4.2%
496	Vagus Nerve Disorder	4.2%
497	Glossopharyngeal Neuralgia	4.2%
498	Abducens Nerve Diseases	4.2%
499	Heavy Metal Poisoning, Nervous System	4.2%
500	Neuromuscular Junction Diseases	4.2%
501	Tauopathies	4.2%
502	Trochlear Nerve Diseases	4.2%
503	Peripheral Nervous System Diseases	4.2%
504	Renal Aminoacidurias	4.2%
505	Fanconi Syndrome	4.2%
506	Pseudohypoaldosteronism	4.2%
507	Liddle Syndrome	4.2%
508	CREST Syndrome	4.2%
509	Anus Neoplasms	4.1%
510	Sigmoid Neoplasms	4.1%
511	Pancreatic Cyst	4.1%
512	Lambert-Eaton Myasthenic Syndrome	4.1%
513	Pouchitis	4%
514	Anus, Imperforate	4%
515	Gastrointestinal Hemorrhage	4%
516	Hemoperitoneum	4%
517	Mesenteric Panniculitis	4%
518	Panniculitis, Peritoneal	4%
519	Peritonitis	4%
520	Peritoneal Fibrosis	4%
521	Encapsulating Peritoneal Sclerosis	4%
522	Anorectal Malformations	4%
523	Appendiceal Neoplasms	4%
524	Colonic Neoplasms	4%
525	Rectal Neoplasms	4%
526	Biliary Fistula	4%
527	Gastric Fistula	4%
528	Tuberculosis, Gastrointestinal	4%
529	Progressive bulbar palsy	4%
530	Bulbar palsy	4%
531	Spinal Cord Ischemia	3.9%
532	Sleep Disorders, Circadian Rhythm	3.9%
533	Crohn Disease	3.9%
534	Duodenal Obstruction	3.9%
535	Enterocolitis, Neutropenic	3.9%
536	Necrotizing Enterocolitis	3.9%
537	Tuberculosis, Central Nervous System	3.9%
538	Hematoma, Subdural	3.9%
539	Hematoma, Epidural, Cranial	3.9%
540	Appendicitis	3.8%
541	Causalgia	3.8%
542	Botulism	3.8%
543	Central Nervous System Cysts	3.8%
544	Olfactory Nerve Injuries	3.8%
545	Gout	3.7%
546	Antley-Bixler Syndrome Phenotype	3.7%
547	Xeroderma Pigmentosum	3.6%
548	Nelson Syndrome	3.6%
549	Duodenal Ulcer	3.6%
550	Peptic Ulcer Perforation	3.6%
551	Gastric ulcer	3.6%
552	Prolactinoma	3.6%
553	Growth Hormone-Secreting Pituitary Adenoma	3.6%
554	Neuromyelitis Optica	3.6%
555	Adenomatous Polyposis Coli	3.5%
556	Tardive Dyskinesia	3.5%
557	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.5%
558	Myopathy	3.5%
559	Optic Neuropathy	3.5%
560	Cystinuria	3.5%
561	Facial Nerve Diseases	3.4%
562	Craniocerebral Trauma	3.4%
563	Parasomnia	3.4%
564	Dyssomnias	3.4%
565	Vestibulocochlear Nerve Diseases	3.4%
566	Decerebrate State	3.4%
567	Hemiparesis	3.4%
568	Hydranencephaly	3.4%
569	Meningism	3.4%
570	Neural Tube Defects	3.4%
571	Paresis	3.4%
572	Seizures	3.4%
573	Sensation Disorders	3.4%
574	Tethered Cord Syndrome	3.4%
575	Central Nervous System Neoplasms	3.4%
576	Complex partial seizures	3.4%
577	Iniencephaly	3.4%
578	Craniorachischisis	3.4%
579	Exencephaly	3.4%
580	Monoparesis	3.4%
581	Septo-Optic Dysplasia	3.4%
582	Cortical Dysplasia	3.4%
583	Neurogenic Inflammation	3.4%
584	Gait Disorders, Neurologic	3.4%
585	Neuromuscular Manifestations	3.4%
586	Malformations of Cortical Development	3.4%
587	Hematoma, Subdural, Intracranial	3.3%
588	Hematoma, Subdural, Chronic	3.3%
589	Hematoma, Subdural, Acute	3.3%
590	Sweating, Gustatory	3.3%
591	Auriculotemporal Syndrome	3.3%
592	Horner Syndrome	3.3%
593	Cecal Diseases	3.3%
594	Cholangitis	3.3%
595	Cholecystitis	3.3%
596	Cholestasis	3.3%
597	Colonic Diseases	3.3%
598	Common Bile Duct Diseases	3.3%
599	Deficiency Diseases	3.3%
600	Esophageal Stenosis	3.3%
601	Ileal Diseases	3.3%
602	Intestinal Obstruction	3.3%
603	Intestinal Perforation	3.3%
604	Jejunal Diseases	3.3%
605	Pneumatosis Cystoides Intestinalis	3.3%
606	Rectal Diseases	3.3%
607	Starvation	3.3%
608	Gastric Dilatation	3.3%
609	Pancreatitis, Chronic	3.3%
610	Gastric outlet obstruction	3.3%
611	Cronkhite-Canada Syndrome	3.3%
612	Refeeding Syndrome	3.3%
613	Intestinal Polyposis	3.3%
614	Multiple Sclerosis	3.3%
615	Neuroaspergillosis	3.3%
616	Facial Nerve Injuries	3.3%
617	Reflex Sympathetic Dystrophy	3.3%
618	Nocturnal Myoclonus Syndrome	3.3%
619	Enterocolitis, Pseudomembranous	3.3%
620	pseudomembranous colitis	3.3%
621	Dysentery, Bacillary	3.3%
622	Colonic Pseudo-Obstruction	3.1%
623	Arthritis, Gouty	3%
624	Colitis, Ischemic	3%
625	Albinism	3%
626	Cystic Fibrosis	3%
627	Pseudorabies	2.9%
628	Anterior Spinal Artery Syndrome	2.9%
629	Myasthenia Gravis, Autoimmune, Experimental	2.9%
630	Jet Lag Syndrome	2.9%
631	Pupil Disorders	2.9%
632	Neurobehavioral Manifestations	2.9%
633	Ophthalmoplegia	2.9%
634	External Ophthalmoplegia	2.9%
635	Paraneoplastic Encephalomyelitis	2.8%
636	Tuberous Sclerosis	2.8%
637	Rift Valley Fever	2.8%
638	Uveomeningoencephalitic Syndrome	2.8%
639	Neurosyphilis	2.8%
640	Sturge-Weber Syndrome	2.8%
641	Vertigo	2.8%
642	Alcohol-Induced Disorders, Nervous System	2.8%
643	Esophageal Perforation	2.8%
644	Intestinal Diseases, Parasitic	2.8%
645	Acrodynia	2.7%
646	Barrett Esophagus	2.7%
647	Deglutition Disorders	2.7%
648	Pancreatic Pseudocyst	2.6%
649	Gastric Antral Vascular Ectasia	2.6%
650	Charcot-Marie-Tooth Disease	2.6%
651	Peptic Ulcer Hemorrhage	2.6%
652	Gastroparesis	2.6%
653	Pancreatitis, Alcoholic	2.6%
654	Brachial Plexus Neuritis	2.6%
655	Neuralgic Amyotrophy	2.6%
656	Carcinoma, Pancreatic Ductal	2.6%
657	Vocal Cord Paralysis	2.5%
658	Neuritis	2.5%
659	Polyneuritis	2.5%
660	Radiculitis	2.5%
661	Toxoplasmosis, Congenital	2.5%
662	Polyneuropathy	2.5%
663	Mononeuritis	2.5%
664	Mononeuropathies	2.5%
665	Brachial Plexus Neuropathies	2.5%
666	Radiculopathy	2.5%
667	Mononeuropathy Multiplex	2.5%
668	Nerve Root Compression	2.5%
669	Malaria, Cerebral	2.5%
670	Cholestasis, Extrahepatic	2.5%
671	Biliary Dyskinesia	2.5%
672	Cholangitis, Sclerosing	2.5%
673	Colonic Diseases, Functional	2.5%
674	Esophageal motility disorders	2.5%
675	Fecal Incontinence	2.5%
676	Fecal Impaction	2.5%
677	Intussusception	2.5%
678	Kwashiorkor	2.5%
679	Magnesium Deficiency	2.5%
680	Mallory-Weiss Syndrome	2.5%
681	Megacolon	2.5%
682	Potassium Deficiency	2.5%
683	Protein Deficiency	2.5%
684	Pyloric Stenosis	2.5%
685	Ichthyosis, X-Linked	2.5%
686	Acalculous Cholecystitis	2.5%
687	Avitaminosis	2.5%
688	Ileus	2.5%
689	Meconium ileus	2.5%
690	Neurocysticercosis	2.4%
691	Voice Disorders	2.4%
692	Voice Disturbance	2.4%
693	Lyme Neuroborreliosis	2.4%
694	Smith-Magenis syndrome	2.4%
695	Dural Arteriovenous Fistula	2.4%
696	Myotonia Congenita	2.4%
697	Cerebrospinal Fluid Otorrhea	2.3%
698	Cerebrospinal Fluid Rhinorrhea	2.3%
699	Neuritis, Autoimmune, Experimental	2.3%
700	Gait Ataxia	2.3%
701	Coma, Post-Head Injury	2.3%
702	Tarsal Tunnel Syndrome	2.3%
703	Cauda Equina Syndrome	2.3%
704	Waterhouse-Friderichsen Syndrome	2.2%
705	Melena	2.2%
706	Hematemesis	2.2%
707	Alcohol Withdrawal Seizures	2.2%
708	Multiple Sclerosis, Chronic Progressive	2.2%
709	Multiple Sclerosis, Relapsing-Remitting	2.2%
710	insulinoma	2.2%
711	Gastrinoma	2.2%
712	Glucagonoma	2.2%
713	Myotonic Dystrophy	2.1%
714	Reflex, Abnormal	2.1%
715	Hyporeflexia	2.1%
716	Hyperreflexia	2.1%
717	Prader-Willi Syndrome	2.1%
718	Akathisia	2%
719	Restlessness	2%
720	Psychomotor Agitation	2%
721	Ascorbic Acid Deficiency	2%
722	Esophageal Achalasia	2%
723	Anal Fissure	2%
724	Intestinal Pseudo-Obstruction	2%
725	Irritable Bowel Syndrome	2%
726	Superior Mesenteric Artery Syndrome	2%
727	Vitamin A Deficiency	2%
728	Vitamin D Deficiency	2%
729	Vitamin E Deficiency	2%
730	Marasmus	2%
731	Emphysematous Cholecystitis	2%
732	Neurogenic Bowel	2%
733	Sphincter of Oddi Dysfunction	2%
734	Anal Ulcer	2%
735	Myositis	2%
736	Optic Atrophy	2%
737	Optic Neuritis	2%
738	Papilledema	2%
739	Strabismus	2%
740	Tolosa-Hunt Syndrome	2%
741	Isaacs syndrome	2%
742	Arsenic Poisoning	2%
743	Myotonic Disorders	2%
744	Myasthenic Syndromes, Congenital	2%
745	Hemorrhoids	2%
746	Diabetic Neuropathies	2%
747	Facial Injuries	2%
748	Facial Neuralgia	2%
749	Diabetic Amyotrophy	2%
750	Diabetic Autonomic Neuropathy	2%
751	Sleep Talking	2%
752	Manganese Poisoning	2%
753	Sleep Disorders, Intrinsic	2%
754	Orthostatic intolerance	2%
755	Afferent Loop Syndrome	2%
756	Anosmia	2%
757	Ataxia	2%
758	Athetosis	2%
759	Catalepsy	2%
760	Dystonia	2%
761	Hemiplegia	2%
762	Locked-In Syndrome	2%
763	Meningeal Neoplasms	2%
764	Meningomyelocele	2%
765	Muscle Hypertonia	2%
766	Muscle hypotonia	2%
767	Myoclonus	2%
768	Myotonia	2%
769	Neuralgia	2%
770	Paraplegia	2%
771	Pseudobulbar Palsy	2%
772	Quadriplegia	2%
773	Short Bowel Syndrome	2%
774	Spasm	2%
775	Spastic Paraplegia	2%
776	Status Epilepticus	2%
777	Taste Disorders	2%
778	Tremor	2%
779	Spina Bifida	2%
780	Monoplegia	2%
781	Hypokinesia	2%
782	Rectocele	2%
783	Paraparesis	2%
784	Bradykinesia	2%
785	Waxy flexibility	2%
786	Action Tremor	2%
787	Resting Tremor	2%
788	Dysosmia	2%
789	Quadriparesis	2%
790	Mercury Poisoning, Nervous System	2%
791	Olfaction Disorders	2%
792	Myokymia	2%
793	Lead Poisoning, Nervous System	2%
794	Vestibular Neuronitis	2%
795	Somatosensory Disorders	2%
796	Neuropathic pain	2%
797	Hyperkinesia	2%
798	Intention tremor	2%
799	Diverticulitis	2%
800	Dumping Syndrome	2%
801	Rectal Prolapse	2%
802	Vipoma	1.9%
803	Carpal Tunnel Syndrome	1.9%
804	neurofibroma	1.9%
805	Sciatica	1.9%
806	Optic Nerve Glioma	1.9%
807	Obesity	1.9%
808	Folic Acid Deficiency	1.8%
809	Pellagra	1.8%
810	Thiamine Deficiency	1.8%
811	Vitamin B 12 Deficiency	1.8%
812	Vitamin B 6 Deficiency	1.8%
813	Pyridoxine Deficiency	1.8%
814	Gait Apraxia	1.8%
815	Alstrom Syndrome	1.8%
816	Hand-Arm Vibration Syndrome	1.7%
817	Beriberi	1.7%
818	Vision Disorders	1.7%
819	Metamorphopsia	1.7%
820	Visual Impairment	1.7%
821	Fibromyalgia	1.7%
822	Optic Neuropathy, Ischemic	1.7%
823	Anterior Ischemic Optic Neuropathy	1.7%
824	Medial Tibial Stress Syndrome	1.7%
825	Giardiasis	1.7%
826	Facial Hemiatrophy	1.7%
827	Melkersson-Rosenthal Syndrome	1.7%
828	Anisocoria	1.7%
829	Confusion	1.7%
830	Facial paralysis	1.7%
831	Lethargy	1.7%
832	Memory Disorders	1.7%
833	Muscle Cramp	1.7%
834	Perceptual Disorders	1.7%
835	Psychomotor Disorders	1.7%
836	Tonic Pupil	1.7%
837	Eosinophilia-Myalgia Syndrome	1.7%
838	Anhedonia	1.7%
839	Disorientation	1.7%
840	Facial Paresis	1.7%
841	Memory Loss	1.7%
842	Hemisensory Neglect	1.7%
843	Dysacusis	1.7%
844	Diverticulum	1.7%
845	Sleep Bruxism	1.7%
846	Diverticulosis	1.7%
847	Anencephaly	1.6%
848	Meningocele	1.6%
849	Muscular Atrophy	1.6%
850	Respiratory Paralysis	1.6%
851	Encephalocele	1.6%
852	Pruritus Ani	1.6%
853	Sciatic Neuropathy	1.6%
854	Ulnar Neuropathies	1.6%
855	Lesion of Sciatic Nerve	1.6%
856	Ulnar Neuritis	1.6%
857	Radial nerve compression	1.6%
858	Radial Tunnel Syndrome	1.6%
859	Peroneal Neuropathies	1.6%
860	Radial Neuropathy	1.6%
861	Median Neuropathy	1.6%
862	Sciatic Nerve Palsy	1.6%
863	Femoral Neuropathy	1.6%
864	Tibial Neuropathy	1.6%
865	Ulnar Nerve Palsy	1.6%
866	Postural Orthostatic Tachycardia Syndrome	1.6%
867	Radial nerve palsy	1.6%
868	Acoustic Neuroma	1.6%
869	Cubital Tunnel Syndrome	1.6%
870	Obesity, Abdominal	1.6%
871	Laryngopharyngeal Reflux	1.5%
872	Duane Retraction Syndrome	1.4%
873	Consciousness Disorders	1.4%
874	Mental Retardation	1.4%
875	Muscle Weakness	1.4%
876	Depressed Level of Consciousness	1.4%
877	Mental deficiency	1.4%
878	Intellectual Disability	1.4%
879	Mobius Syndrome	1.4%
880	Bell Palsy	1.4%
881	Catatonia	1.4%
882	Herpes Zoster Oticus	1.4%
883	Peutz-Jeghers Syndrome	1.4%
884	Aphonia	1.4%
885	Sleep Deprivation	1.4%
886	Dysphonia	1.4%
887	Classical Lissencephalies and Subcortical Band Heterotopias	1.4%
888	Pediatric Obesity	1.4%
889	Anemia, Pernicious	1.4%
890	Vitamin K Deficiency	1.4%
891	Thoracic Outlet Syndrome	1.3%
892	Esotropia	1.3%
893	Exotropia	1.3%
894	Hypotension, Orthostatic	1.3%
895	Sleep Apnea Syndromes	1.3%
896	Polymyositis	1.3%
897	Post-Exercise Hypotension	1.3%
898	Disorders of Excessive Somnolence	1.3%
899	Sleep Initiation and Maintenance Disorders	1.3%
900	Night Terrors	1.3%
901	Somnambulism	1.3%
902	Trigeminal Nerve Disorder	1.3%
903	Transient Insomnia	1.3%
904	Sleep Paralysis	1.3%
905	Chronic Insomnia	1.3%
906	REM Sleep Behavior Disorder	1.3%
907	Hypersomnia	1.3%
908	Dermal Sinus	1.3%
909	Dysgeusia	1.3%
910	Formication	1.3%
911	Hyperalgesia	1.3%
912	Hyperesthesia	1.3%
913	Hypesthesia	1.3%
914	Language Disorders	1.3%
915	Numbness	1.3%
916	Paresthesia	1.3%
917	Paraparesis, Spastic	1.3%
918	Spina Bifida Cystica	1.3%
919	Trismus	1.3%
920	Spina Bifida Occulta	1.3%
921	Epilepsia Partialis Continua	1.3%
922	Hypogeusia	1.3%
923	Meningeal Carcinomatosis	1.3%
924	Brown-Sequard Syndrome	1.3%
925	Lissencephaly	1.3%
926	Polymicrogyria	1.3%
927	Pachygyria	1.3%
928	Schizencephaly	1.3%
929	Lockjaw	1.3%
930	Allodynia	1.3%
931	Lead Poisoning, Nervous System, Childhood	1.3%
932	Lead Poisoning, Nervous System, Adult	1.3%
933	Periventricular Nodular Heterotopia	1.3%
934	Ageusia	1.3%
935	Myalgia	1.2%
936	Polyradiculopathy	1.2%
937	Scurvy	1.2%
938	Alexia	1.2%
939	Dyslexia	1.2%
940	Eye Injuries	1.1%
941	Aicardi's syndrome	1.1%
942	Cryptosporidiosis	1.1%
943	Hoarseness	1.1%
944	Muscular Dystrophy	1.1%
945	Congenital nystagmus	1.1%
946	Orbital Myositis	1.1%
947	Neurofibrosarcoma	1.1%
948	Diplopia	1.1%
949	Muscle Rigidity	1.1%
950	Muscle Spasticity	1.1%
951	Scotoma	1.1%
952	Photophobia	1.1%
953	Cogwheel Rigidity	1.1%
954	Hemifacial Spasm	1.1%
955	Amaurosis	1.1%
956	Blindness	1.1%
957	Nuchal Rigidity	1.1%
958	Pyomyositis	1.1%
959	Alcohol Withdrawal Delirium	1.1%
960	Agnosia	1.1%
961	Apraxias	1.1%
962	Hallucinations	1.1%
963	Hemianopsia	1.1%
964	Hyperacusis	1.1%
965	Tinnitus	1.1%
966	Visual Agnosia	1.1%
967	Anosognosia	1.1%
968	Wernicke-Korsakoff Syndrome	1.1%
969	Phonophobia	1.1%
970	Hearing Loss	1.1%
971	Sarcopenia	1.1%
972	Holoprosencephaly	1%
973	Sleep Apnea, Obstructive	1%
974	Sleep Apnea, Central	1%
975	Narcolepsy	1%
976	Trigeminal Neuralgia	1%
977	Kleine-Levin Syndrome	1%
978	Agraphia	1%
979	Anomia	1%
980	Cluttering	1%
981	Language Development Disorders	1%
982	Speech Disorders	1%
983	Syncope	1%
984	Stupor	1%
985	Dysgraphia	1%
986	Presyncope	1%
987	Dyslalia	1%
988	Amnesia	0.9%
989	Delirium	0.9%
990	Dissociative Amnesia	0.9%
991	Color blindness	0.9%
992	Global Amnesia	0.9%
993	Cri-du-Chat Syndrome	0.9%
994	Down Syndrome	0.9%
995	Trisomy 21	0.9%
996	POEMS Syndrome	0.9%
997	Meningioma	0.9%
998	Williams Syndrome	0.9%
999	Microcephaly	0.9%
1000	Macrocephaly	0.9%
1001	Porencephaly	0.9%
1002	Eye Burns	0.8%
1003	Welander Distal Myopathy	0.8%
1004	Amaurosis Fugax	0.8%
1005	Blindness, Cortical	0.8%
1006	Dyscalculia	0.8%
1007	Rett Syndrome	0.8%
1008	Phantom pain	0.8%
1009	Phantom Limb Pain	0.8%
1010	Deafness	0.8%
1011	Hearing Loss, Sudden	0.8%
1012	Gerstmann Syndrome	0.8%
1013	Hearing Loss, Bilateral	0.8%
1014	Hearing Loss, High-Frequency	0.8%
1015	Hearing Loss, Mixed Conductive-Sensorineural	0.8%
1016	Prosopagnosia	0.8%
1017	Apraxia, Ideomotor	0.8%
1018	Charles Bonnet Syndrome	0.8%
1019	Hearing Loss, Unilateral	0.8%
1020	Complete Hearing Loss	0.8%
1021	Alien Hand Syndrome	0.8%
1022	Deaf Mutism	0.8%
1023	Cataplexy	0.8%
1024	Aphasia	0.8%
1025	Articulation Disorders	0.8%
1026	Echolalia	0.8%
1027	Stuttering	0.8%
1028	Dysphasia	0.8%
1029	Dysarthria	0.7%
1030	Dermatomyositis	0.7%
1031	Corneal Scar	0.7%
1032	Muscular Dystrophy, Duchenne	0.7%
1033	Retrograde amnesia	0.7%
1034	Amnesia, Anterograde	0.7%
1035	Mutism	0.7%
1036	Selective Mutism	0.7%
1037	Rubinstein-Taybi Syndrome	0.7%
1038	Alexia, Pure	0.6%
1039	Fragile X Syndrome	0.6%
1040	Corneal Perforation	0.6%

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