MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Isaacs syndrome

(UMLS:C0242287)

Definition:: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
UMLS ID:: C0242287
MeSH ID:: D020386

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.392

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.668.829.425

Synonym(s)

Isaacs syndrome

Autosomal recessive axonal neuropathy with neuromyotonia

Autosomal recessive neuromyotonia with axonal neuropathy

Continuous muscle fiber activity

Continuous muscle fiber activity syndrome

Continuous muscle fibre activity

Gamstorp-Wohlfart syndrome

Isaac's syndrome

Isaacs

10.

Isaacs-Mertens syndrome

11.

Myokymia, myotonia and muscle wasting

12.

NEUROMYOTONIA AND AXONAL NEUROPATHY, AUTOSOMAL RECESSIVE

13.

Neuromyotonia

14.

isaac syndrome

15.

isaac's syndrome

16.

isaacs syndrome

17.

isaacs' syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Azathioprine	7561930	CTD
2	Carbamazepine	11360270	CTD
3	Penicillamine	466063	CTD
4	Phenytoin	466063	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Brachial Plexus Neuritis	35%
2	Neuralgic Amyotrophy	35%
3	Tarsal Tunnel Syndrome	32%
4	Cauda Equina Syndrome	32%
5	Neuritis	31.8%
6	Polyneuritis	31.8%
7	Radiculitis	31.8%
8	Polyneuropathy	31.8%
9	Mononeuritis	31.8%
10	Mononeuropathies	31.8%
11	Brachial Plexus Neuropathies	31.8%
12	Radiculopathy	31.8%
13	Mononeuropathy Multiplex	31.8%
14	Nerve Root Compression	31.8%
15	Myositis	31%
16	Myotonic Disorders	31%
17	Causalgia	30.7%
18	Fibromyalgia	30.6%
19	Complex Regional Pain Syndromes	29.3%
20	Contracture	28.1%
21	Myofascial Pain Syndromes	27.9%
22	Rhabdomyolysis	27.9%
23	Chronic Fatigue Syndrome	27.4%
24	Carpal Tunnel Syndrome	25.6%
25	Guillain-Barre Syndrome	25.4%
26	Sciatica	25.3%
27	Medial Tibial Stress Syndrome	25%
28	Mitochondrial Myopathies	24.7%
29	Eosinophilia-Myalgia Syndrome	24.5%
30	Diabetic Neuropathies	23.7%
31	Diabetic Amyotrophy	23.7%
32	Diabetic Autonomic Neuropathy	23.7%
33	Peripheral Nerve Injuries	23.6%
34	Sciatic Neuropathy	23.6%
35	Ulnar Neuropathies	23.6%
36	Lesion of Sciatic Nerve	23.6%
37	Ischemic contracture	23.6%
38	Ulnar Neuritis	23.6%
39	Radial nerve compression	23.6%
40	Radial Tunnel Syndrome	23.6%
41	Peroneal Neuropathies	23.6%
42	Radial Neuropathy	23.6%
43	Median Neuropathy	23.6%
44	Sciatic Nerve Palsy	23.6%
45	Femoral Neuropathy	23.6%
46	Tibial Neuropathy	23.6%
47	Ulnar Nerve Palsy	23.6%
48	Radial nerve palsy	23.6%
49	Neuralgia	23.5%
50	Neuropathic pain	23.5%
51	Arthrogryposis	23.3%
52	Cubital Tunnel Syndrome	23%
53	Polymyositis	22.7%
54	Polymyalgia Rheumatica	22.2%
55	Compartment syndromes	21.1%
56	Tendinitis	21.1%
57	Motor Neuron Disease	21.1%
58	Tendinopathy	21.1%
59	Reflex Sympathetic Dystrophy	21%
60	Neuromuscular Junction Diseases	20.9%
61	Acrodynia	20.6%
62	Fibrodysplasia Ossificans Progressiva	20.5%
63	Myoglobinuria	20.5%
64	Myositis Ossificans	20.5%
65	Tenosynovitis	20.5%
66	Hip Contracture	20.3%
67	Familial Periodic Paralysis	20.2%
68	Hand-Arm Vibration Syndrome	20%
69	Myotonic Dystrophy	19.7%
70	Polyradiculopathy	19.6%
71	Muscle Cramp	19%
72	Polyradiculoneuropathy	18.9%
73	Polyradiculoneuritis	18.9%
74	Muscular Dystrophy	18.4%
75	Orbital Myositis	18.4%
76	Muscle Rigidity	18.2%
77	Muscle Spasticity	18.2%
78	Cogwheel Rigidity	18.2%
79	Nuchal Rigidity	18.2%
80	Temporomandibular Joint Dysfunction Syndrome	18.1%
81	Pyomyositis	18.1%
82	Thoracic Outlet Syndrome	17.9%
83	Myotonia Congenita	17.3%
84	Myalgia	17.2%
85	Miller Fisher Syndrome	16.4%
86	Myopathy	16.4%
87	Stiff-Person Syndrome	16.1%
88	Muscle Weakness	16%
89	Temporomandibular Joint Disorders	15.3%
90	Anterior Compartment Syndrome	15.3%
91	Enthesopathy	15.3%
92	Abdominal Compartment Syndrome	15.3%
93	Welander Distal Myopathy	15%
94	Hypokalemic periodic paralysis	14.8%
95	Bone Diseases	14.6%
96	Fasciitis	14.6%
97	Foot Deformities	14.6%
98	Arthropathy	14.6%
99	Mitochondrial Encephalomyopathies	14.2%
100	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	14.1%
101	Osteoarthropathy, Secondary Hypertrophic	14%
102	Fasciitis, Plantar	14%
103	Neuritis, Autoimmune, Experimental	13.8%
104	Musculoskeletal Pain	13.6%
105	Progressive bulbar palsy	13.6%
106	Bulbar palsy	13.6%
107	neurofibroma	13.5%
108	Spinal Muscular Atrophy	13.5%
109	Progressive Muscular Atrophy	13.5%
110	Poliomyelitis	13.4%
111	Dermatomyositis	12.7%
112	Muscular Dystrophy, Duchenne	12.5%
113	Myasthenia Gravis	12.3%
114	Cranial nerve diseases	12.2%
115	Demyelinating Diseases	12.2%
116	Demyelination	12.2%
117	Chronobiology Disorders	12.2%
118	Dupuytren Contracture	12.2%
119	POEMS Syndrome	11.7%
120	Charcot-Marie-Tooth Disease	11.5%
121	Amyotrophic Lateral Sclerosis	11.5%
122	Jaw Diseases	11.3%
123	Osteoarthritis, Spine	11.3%
124	Osteochondritis	11.1%
125	Metatarsalgia	11%
126	Cartilage Diseases	10.9%
127	Foot Diseases	10.9%
128	Rheumatism	10.9%
129	Chondromalacia	10.9%
130	Pectus carinatum	10.8%
131	Myasthenic Syndromes, Congenital	10.3%
132	Botulism	10.2%
133	Periarthritis	10.2%
134	Platybasia	10.1%
135	Ankylosing spondylitis	9.8%
136	Gout	9.6%
137	Multiple System Atrophy	9.6%
138	Pectus excavatum	9.6%
139	Rheumatic Fever	9.5%
140	Trauma, Nervous System	9.4%
141	Arthritis	9.3%
142	Bone Diseases, Developmental	9.3%
143	Bursitis	9.3%
144	Hyperostosis	9.3%
145	Joint Instability	9.3%
146	Osteitis	9.3%
147	Osteitis Deformans	9.3%
148	Osteochondrosis	9.3%
149	Spinal Diseases	9.3%
150	Synovitis	9.3%
151	Joint laxity	9.3%
152	Polyarthritis	9.3%
153	Frozen shoulder	9.3%
154	Patellofemoral Pain Syndrome	9.3%
155	Lambert-Eaton Myasthenic Syndrome	9.3%
156	Osteoarthritis, Knee	9.2%
157	Amyloid Neuropathies, Familial	9.1%
158	Talipes	9.1%
159	Nervous System Neoplasms	9.1%
160	Neurologic Manifestations	9.1%
161	Neurotoxicity Syndromes	9.1%
162	Klippel-Feil Syndrome	8.8%
163	Synostosis	8.8%
164	Ocular Motility Disorders	8.7%
165	Cyclophoria	8.7%
166	Encephalomyelitis	8.6%
167	Prion Diseases	8.6%
168	Autonomic Dysreflexia	8.6%
169	Neurofibrosarcoma	8.4%
170	Restless Legs Syndrome	8.3%
171	MELAS Syndrome	8.1%
172	Gigantism	8.1%
173	Spinal Neoplasms	8.1%
174	Spondylitis	8.1%
175	Arthritis, Psoriatic	8.1%
176	Rheumatoid Arthritis	8%
177	Juvenile arthritis	8%
178	Spondylarthropathies	7.9%
179	Craniosynostosis	7.8%
180	Syndactyly	7.8%
181	Brachycephaly	7.8%
182	Meningoencephalitis	7.8%
183	Subacute Combined Degeneration	7.8%
184	Congenital clubfoot	7.8%
185	Vertical Talus	7.8%
186	Parkinson Disease	7.7%
187	Marchiafava-Bignami Disease	7.7%
188	Acrocephalosyndactylia	7.7%
189	Arthritis, Reactive	7.5%
190	Ophthalmoplegic Migraine	7.5%
191	Arthritis, Gouty	7.5%
192	Kearns-Sayre syndrome	7.4%
193	Sleep Wake Disorders	7.4%
194	Craniofacial Dysostosis	7.3%
195	Rheumatoid Nodule	7.3%
196	Alstrom Syndrome	7.3%
197	Bone Diseases, Endocrine	7.3%
198	Spinal Cord Injuries	7.1%
199	Myasthenia Gravis, Autoimmune, Experimental	7%
200	Bone Diseases, Infectious	7%
201	Bone neoplasms	7%
202	Maxillary Diseases	7%
203	Osteopenia	7%
204	Brain Diseases	7%
205	Dysautonomia	7%
206	Meningitis	7%
207	Movement Disorders	7%
208	Pachymeningitis	7%
209	Spinal Cord Diseases	7%
210	Vagus Nerve Disorder	7%
211	Glossopharyngeal Neuralgia	7%
212	Abducens Nerve Diseases	7%
213	Heavy Metal Poisoning, Nervous System	7%
214	Tauopathies	7%
215	Trochlear Nerve Diseases	7%
216	Lewy Body Disease	6.9%
217	Bone Resorption	6.9%
218	Hemarthrosis	6.9%
219	Tietze's Syndrome	6.9%
220	Limb Deformities, Congenital	6.9%
221	Craniofacial Abnormalities	6.9%
222	Aseptic Necrosis of Bone	6.9%
223	Striatonigral Degeneration	6.9%
224	Asterixis	6.8%
225	Ballismus	6.8%
226	Ainhum	6.8%
227	Bunion	6.8%
228	Dysostoses	6.8%
229	Spinal Stenosis	6.8%
230	Spondylosis	6.8%
231	Intervertebral Disc Degeneration	6.8%
232	Sacroiliitis	6.8%
233	Myelitis	6.8%
234	Refsum Disease	6.8%
235	Dandy-Walker Syndrome	6.7%
236	Pneumocephalus	6.7%
237	Poland Syndrome	6.6%
238	Discitis	6.6%
239	Progressive supranuclear palsy	6.2%
240	Leukoencephalitis, Acute Hemorrhagic	6.1%
241	Neuroleptic Malignant Syndrome	6.1%
242	Myelinolysis, Central Pontine	6.1%
243	Felty Syndrome	6.1%
244	Epidural Abscess	6.1%
245	Olfactory Nerve Injuries	6.1%
246	MPTP Poisoning	6%
247	Myelitis, Transverse	6%
248	Shy-Drager Syndrome	5.9%
249	Subdural Effusion	5.9%
250	Parkinsonian Disorders	5.9%
251	Nocturnal Myoclonus Syndrome	5.9%
252	Sleep Disorders, Circadian Rhythm	5.9%
253	Encephalomyelitis, Acute Disseminated	5.8%
254	Goldenhar Syndrome	5.7%
255	Central Nervous System Cysts	5.6%
256	Chondrodysplasia Punctata	5.6%
257	Enchondromatosis	5.6%
258	Lordosis	5.6%
259	Osteosclerosis	5.6%
260	Spondylolysis	5.6%
261	kyphosis	5.6%
262	Kashin-Beck Disease	5.6%
263	Neuromyelitis Optica	5.6%
264	Opsoclonus-Myoclonus Syndrome	5.6%
265	Dystonia Musculorum Deformans	5.6%
266	Acromegaly	5.5%
267	Dyskinesia, Drug-Induced	5.5%
268	Jaw Abnormalities	5.5%
269	Tuberculosis, Spinal	5.5%
270	Central Nervous System Infection	5.5%
271	Optic Neuropathy	5.5%
272	Gastroschisis	5.4%
273	Prognathism	5.4%
274	Brain Injuries	5.4%
275	Brain Neoplasms	5.4%
276	Multiple Sclerosis	5.4%
277	Spinal Cord Neoplasms	5.4%
278	Congenital Hypothyroidism	5.3%
279	Facial Nerve Diseases	5.3%
280	Craniocerebral Trauma	5.3%
281	Parasomnia	5.3%
282	Dyssomnias	5.3%
283	Facial Nerve Injuries	5.2%
284	Mandibulofacial Dysostosis	5.2%
285	Rheumatoid Vasculitis	5.2%
286	Vestibulocochlear Nerve Diseases	5.2%
287	Arthritis, Infectious	5.2%
288	Decerebrate State	5.2%
289	Hemiparesis	5.2%
290	Hydranencephaly	5.2%
291	Meningism	5.2%
292	Multiple Epiphyseal Dysplasia	5.2%
293	Neural Tube Defects	5.2%
294	Osteochondrodysplasias	5.2%
295	Paresis	5.2%
296	Seizures	5.2%
297	Sensation Disorders	5.2%
298	Tethered Cord Syndrome	5.2%
299	Central Nervous System Neoplasms	5.2%
300	Complex partial seizures	5.2%
301	Iniencephaly	5.2%
302	Craniorachischisis	5.2%
303	Exencephaly	5.2%
304	Monoparesis	5.2%
305	Septo-Optic Dysplasia	5.2%
306	Cortical Dysplasia	5.2%
307	Neurogenic Inflammation	5.2%
308	Gait Disorders, Neurologic	5.2%
309	Neuromuscular Manifestations	5.2%
310	Malformations of Cortical Development	5.2%
311	Rubinstein-Taybi Syndrome	5.2%
312	Sweating, Gustatory	5.1%
313	Auriculotemporal Syndrome	5.1%
314	Osteomyelitis	5.1%
315	Osteoporosis	5.1%
316	Periostitis	5.1%
317	Bone Demineralization, Pathologic	5.1%
318	Post-Traumatic Osteoporosis	5.1%
319	Arthritis, Experimental	5.1%
320	Alveolar Bone Loss	5%
321	Amelia	5%
322	Arachnodactyly	5%
323	Ectromelia	5%
324	Femur Head Necrosis	5%
325	Hemimelia	5%
326	Horner Syndrome	5%
327	Phocomelia	5%
328	Sirenomelia	5%
329	Polydactyly	5%
330	Brachydactyly	5%
331	Plagiocephaly	5%
332	Lower Extremity Deformities, Congenital	5%
333	Upper Extremity Deformities, Congenital	5%
334	Osteolysis	5%
335	Melorheostosis	5%
336	Osteopetrosis	5%
337	Spondylolisthesis	5%
338	Meige Syndrome	5%
339	Cerebral Ventriculitis	5%
340	Microcephaly	5%
341	Macrocephaly	5%
342	Leukoencephalopathy, Progressive Multifocal	5%
343	Epilepsy, Post-Traumatic	4.9%
344	Antley-Bixler Syndrome Phenotype	4.9%
345	Akathisia, Drug-Induced	4.9%
346	Scrapie	4.8%
347	Central Cord Syndrome	4.8%
348	Limbic Encephalitis	4.7%
349	Presenile dementia	4.7%
350	Senile dementia	4.7%
351	Meningitis, Bacterial	4.7%
352	Meningitis, Fungal	4.7%
353	Chorea	4.7%
354	Huntington Disease	4.6%
355	Nail-Patella Syndrome	4.6%
356	Giant Cell Epulis	4.6%
357	Sicca Syndrome	4.6%
358	Posterior Leukoencephalopathy Syndrome	4.6%
359	Sjogren's Syndrome	4.6%
360	Posterior reversible encephalopathy syndrome	4.6%
361	Akinetic Mutism	4.5%
362	Anoxic Encephalopathy	4.5%
363	Arachnoiditis	4.5%
364	Basal Ganglia Diseases	4.5%
365	Brain Damage, Chronic	4.5%
366	Cerebellar Diseases	4.5%
367	Encephalitis	4.5%
368	Encephalomalacia	4.5%
369	Epilepsy	4.5%
370	Hydrocephalus	4.5%
371	Congenital Hydrocephalus	4.5%
372	Hypothalamic Diseases	4.5%
373	Aseptic Meningitis	4.5%
374	Syringomyelia	4.5%
375	Thalamic Diseases	4.5%
376	Intracranial Hypertension	4.5%
377	Aura	4.5%
378	Leukoencephalopathy	4.5%
379	Essential Tremor	4.5%
380	Neuroaxonal Dystrophies	4.5%
381	Familial Tremor	4.5%
382	Headache Disorders	4.5%
383	Intracranial Hypotension	4.5%
384	Brain Edema	4.5%
385	Brain Hypoxia	4.5%
386	Aqueductal Stenosis	4.5%
387	Pneumorrhachis	4.5%
388	Writer's Cramp	4.5%
389	Lafora Disease	4.5%
390	Unverricht-Lundborg Syndrome	4.5%
391	Brain Abscess	4.5%
392	Ophthalmoplegia	4.5%
393	External Ophthalmoplegia	4.5%
394	Arthralgia	4.5%
395	Polyarthralgia	4.5%
396	Lupus Vasculitis, Central Nervous System	4.4%
397	Porencephaly	4.4%
398	Cerebellar Neoplasms	4.4%
399	Vasculitis, Central Nervous System	4.3%
400	Palatal Neoplasms	4.3%
401	Jet Lag Syndrome	4.3%
402	Micrognathism	4.3%
403	Pierre Robin Syndrome	4.3%
404	Dwarfism	4.3%
405	Pupil Disorders	4.3%
406	Neurobehavioral Manifestations	4.3%
407	Brain Death	4.2%
408	Coma, Post-Head Injury	4.2%
409	Canavan Disease	4.2%
410	Alexander Disease	4.2%
411	Hip Dislocation	4.2%
412	Osteoporosis, Postmenopausal	4.2%
413	Shoulder Dislocation	4.2%
414	Paraneoplastic Encephalomyelitis	4.2%
415	Hip Dysplasia	4.2%
416	Myoclonic Epilepsy	4.1%
417	Epilepsy, Temporal Lobe	4.1%
418	Epilepsy, Rolandic	4.1%
419	Benign Rolandic Epilepsy	4.1%
420	Uveomeningoencephalitic Syndrome	4.1%
421	Sturge-Weber Syndrome	4.1%
422	Vertigo	4.1%
423	Alcohol-Induced Disorders, Nervous System	4.1%
424	Dementia, Vascular	4.1%
425	Brain Hemorrhage, Traumatic	4.1%
426	Tuberous Sclerosis	4%
427	Joint Tuberculosis	4%
428	Tuberculosis, Osteoarticular	4%
429	Bone Tuberculosis	4%
430	Friedreich Ataxia	4%
431	Creutzfeldt-Jakob disease	4%
432	Basal Ganglia Cerebrovascular Disease	4%
433	Brain Injuries, Diffuse	4%
434	Traumatic Brain Injury	4%
435	Cerebellar Ataxia	4%
436	Supratentorial Neoplasms	4%
437	Torticollis	4%
438	Laryngomalacia	4%
439	Multiple Sclerosis, Chronic Progressive	4%
440	Multiple Sclerosis, Relapsing-Remitting	4%
441	Ataxia Telangiectasia	4%
442	Amblyopia	3.9%
443	Vocal Cord Paralysis	3.9%
444	Paraneoplastic Cerebellar Degeneration	3.9%
445	Cerebrospinal Fluid Otorrhea	3.9%
446	Cerebrospinal Fluid Rhinorrhea	3.9%
447	Gait Ataxia	3.9%
448	Retrognathia	3.8%
449	Eosinophilic Granuloma	3.8%
450	Cockayne Syndrome	3.8%
451	Tuberculosis, Meningeal	3.7%
452	Holoprosencephaly	3.7%
453	Carotid Artery Injuries	3.7%
454	Juvenile Myoclonic Epilepsy	3.7%
455	Myoclonic Epilepsies, Progressive	3.7%
456	Vascular Headaches	3.7%
457	Hypoxia-Ischemia, Brain	3.6%
458	Tardive Dyskinesia	3.6%
459	Persistent Vegetative State	3.6%
460	Voice Disorders	3.5%
461	Voice Disturbance	3.5%
462	Brain Diseases, Metabolic	3.4%
463	Cerebrovascular Disorders	3.4%
464	Optic Atrophy	3.4%
465	Optic Neuritis	3.4%
466	Papilledema	3.4%
467	Strabismus	3.4%
468	Tolosa-Hunt Syndrome	3.4%
469	Cerebrovascular Insufficiency	3.4%
470	Arsenic Poisoning	3.4%
471	Dementia	3.4%
472	Central Nervous System Fungal Infections	3.4%
473	Conus Medullaris Syndrome	3.4%
474	Spinal Cord Vascular Diseases	3.4%
475	Hepatolenticular Degeneration	3.4%
476	Smith-Magenis syndrome	3.4%
477	Osteogenesis Imperfecta	3.4%
478	Facial Injuries	3.4%
479	Facial Neuralgia	3.4%
480	Maxillofacial Abnormalities	3.4%
481	Sleep Talking	3.4%
482	Manganese Poisoning	3.4%
483	Dural Arteriovenous Fistula	3.4%
484	Sleep Disorders, Intrinsic	3.4%
485	Orthostatic intolerance	3.4%
486	Cerebral Palsy	3.4%
487	Epilepsies, Partial	3.4%
488	Epilepsy, Generalized	3.4%
489	Pseudotumor Cerebri	3.4%
490	Hypertensive Encephalopathy	3.4%
491	Simple Partial Seizures	3.4%
492	Epilepsy, Reflex	3.4%
493	Alice in Wonderland Syndrome	3.4%
494	Postural Orthostatic Tachycardia Syndrome	3.4%
495	Headache Disorders, Primary	3.4%
496	Headache Disorders, Secondary	3.4%
497	Medication overuse headache	3.4%
498	Anosmia	3.4%
499	Ataxia	3.4%
500	Athetosis	3.4%
501	Catalepsy	3.4%
502	Dystonia	3.4%
503	Hemiplegia	3.4%
504	Locked-In Syndrome	3.4%
505	Meningeal Neoplasms	3.4%
506	Meningomyelocele	3.4%
507	Muscle Hypertonia	3.4%
508	Muscle hypotonia	3.4%
509	Myoclonus	3.4%
510	Myotonia	3.4%
511	Paraplegia	3.4%
512	Pseudobulbar Palsy	3.4%
513	Quadriplegia	3.4%
514	Spasm	3.4%
515	Spastic Paraplegia	3.4%
516	Status Epilepticus	3.4%
517	Taste Disorders	3.4%
518	Tremor	3.4%
519	Spina Bifida	3.4%
520	Monoplegia	3.4%
521	Hypokinesia	3.4%
522	Paraparesis	3.4%
523	Bradykinesia	3.4%
524	Waxy flexibility	3.4%
525	Action Tremor	3.4%
526	Resting Tremor	3.4%
527	Dysosmia	3.4%
528	Quadriparesis	3.4%
529	Mercury Poisoning, Nervous System	3.4%
530	Olfaction Disorders	3.4%
531	Myokymia	3.4%
532	Lead Poisoning, Nervous System	3.4%
533	Vestibular Neuronitis	3.4%
534	Somatosensory Disorders	3.4%
535	Hyperkinesia	3.4%
536	Intention tremor	3.4%
537	Rickets	3.3%
538	Leukomalacia, Periventricular	3.3%
539	Bronchomalacia	3.3%
540	Tracheomalacia	3.3%
541	Alcohol Withdrawal Seizures	3.3%
542	Mastoiditis	3.3%
543	Petrositis	3.3%
544	Akathisia	3.3%
545	Restlessness	3.3%
546	Psychomotor Agitation	3.3%
547	Basal Cell Nevus Syndrome	3.3%
548	Shoulder Pain	3.3%
549	Diffuse Axonal Injury	3.3%
550	Brain Stem Neoplasms	3.3%
551	Brain Concussion	3.3%
552	Pituitary Adenoma	3.1%
553	Pituitary Neoplasms	3.1%
554	Cleft Palate	3.1%
555	Toxoplasmosis, Cerebral	3.1%
556	Optic Nerve Glioma	3.1%
557	Vertebral Artery Dissection	3.1%
558	Amnesia, Transient Global	3.1%
559	Gait Apraxia	3%
560	Meningitis, Cryptococcal	3%
561	Meningitis, Listeria	3%
562	Meningitis, Haemophilus	3%
563	Meningitis, Pneumococcal	3%
564	Frontotemporal dementia	3%
565	Basal Ganglia Hemorrhage	2.9%
566	Choroid Plexus Papilloma	2.9%
567	Reflex, Abnormal	2.9%
568	Hyporeflexia	2.9%
569	Hyperreflexia	2.9%
570	Pseudohypoparathyroidism	2.9%
571	Vision Disorders	2.8%
572	Metamorphopsia	2.8%
573	Visual Impairment	2.8%
574	Post-Traumatic Headache	2.8%
575	Tension Headache	2.8%
576	Epilepsy, Complex Partial	2.8%
577	Migraine Disorders	2.8%
578	Abdominal Migraine	2.8%
579	Status Migrainosus	2.8%
580	Cervicogenic Headache	2.8%
581	Pituitary Apoplexy	2.8%
582	Optic Neuropathy, Ischemic	2.8%
583	Anterior Ischemic Optic Neuropathy	2.8%
584	Central Nervous System Bacterial Infections	2.8%
585	Facial Hemiatrophy	2.7%
586	Melkersson-Rosenthal Syndrome	2.7%
587	Brain Contusion	2.7%
588	Osteomalacia	2.7%
589	Brain Infarction	2.7%
590	Anisocoria	2.7%
591	Confusion	2.7%
592	Facial paralysis	2.7%
593	Lethargy	2.7%
594	Memory Disorders	2.7%
595	Perceptual Disorders	2.7%
596	Psychomotor Disorders	2.7%
597	Tonic Pupil	2.7%
598	Anhedonia	2.7%
599	Disorientation	2.7%
600	Facial Paresis	2.7%
601	Memory Loss	2.7%
602	Hemisensory Neglect	2.7%
603	Dysacusis	2.7%
604	Subarachnoid Hemorrhage, Traumatic	2.7%
605	Sleep Bruxism	2.7%
606	Carotid Artery, Internal, Dissection	2.7%
607	Anencephaly	2.7%
608	Meningocele	2.7%
609	Muscular Atrophy	2.7%
610	Respiratory Paralysis	2.7%
611	Encephalocele	2.7%
612	Subacute Sclerosing Panencephalitis	2.7%
613	Putaminal Hemorrhage	2.7%
614	Tetany	2.7%
615	Pituitary Diseases	2.7%
616	Infarction, Middle Cerebral Artery	2.6%
617	Infarction, Anterior Cerebral Artery	2.6%
618	Infarction, Posterior Cerebral Artery	2.6%
619	Classical Lissencephalies and Subcortical Band Heterotopias	2.6%
620	Carotid Artery Diseases	2.5%
621	Brain Ischemia	2.5%
622	Esotropia	2.5%
623	Exotropia	2.5%
624	Hypotension, Orthostatic	2.5%
625	Noonan Syndrome	2.5%
626	Sleep Apnea Syndromes	2.5%
627	Cerebrovascular accident	2.5%
628	Kluver-Bucy Syndrome	2.5%
629	Vasospasm, Intracranial	2.5%
630	Spinal Cord Ischemia	2.5%
631	Intracranial Arterial Diseases	2.5%
632	Post-Exercise Hypotension	2.5%
633	Cluster Headache	2.5%
634	Migraine with Aura	2.5%
635	Familial Hemiplegic Migraine	2.5%
636	Chronic Paroxysmal Hemicrania	2.5%
637	SUNCT Syndrome	2.5%
638	Paroxysmal Hemicrania	2.5%
639	Disorders of Excessive Somnolence	2.5%
640	Sleep Initiation and Maintenance Disorders	2.5%
641	Night Terrors	2.5%
642	Somnambulism	2.5%
643	Trigeminal Nerve Disorder	2.5%
644	Transient Insomnia	2.5%
645	Sleep Paralysis	2.5%
646	Chronic Insomnia	2.5%
647	REM Sleep Behavior Disorder	2.5%
648	Hypersomnia	2.5%
649	Dermal Sinus	2.5%
650	Dysgeusia	2.5%
651	Formication	2.5%
652	Hyperalgesia	2.5%
653	Hyperesthesia	2.5%
654	Hypesthesia	2.5%
655	Language Disorders	2.5%
656	Numbness	2.5%
657	Paresthesia	2.5%
658	Paraparesis, Spastic	2.5%
659	Spina Bifida Cystica	2.5%
660	Trismus	2.5%
661	Spina Bifida Occulta	2.5%
662	Epilepsia Partialis Continua	2.5%
663	Hypogeusia	2.5%
664	Meningeal Carcinomatosis	2.5%
665	Brown-Sequard Syndrome	2.5%
666	Lissencephaly	2.5%
667	Polymicrogyria	2.5%
668	Pachygyria	2.5%
669	Schizencephaly	2.5%
670	Lockjaw	2.5%
671	Allodynia	2.5%
672	Lead Poisoning, Nervous System, Childhood	2.5%
673	Lead Poisoning, Nervous System, Adult	2.5%
674	Periventricular Nodular Heterotopia	2.5%
675	Ageusia	2.5%
676	Tuberculosis, Central Nervous System	2.5%
677	Auditory Perceptual Disorders	2.5%
678	Adrenoleukodystrophy	2.5%
679	Cerebral Infarction	2.4%
680	Brain Stem Infarctions	2.4%
681	Acoustic Neuroma	2.4%
682	Giant Cell Arteritis	2.4%
683	Temporal Arteritis	2.4%
684	Alexia	2.3%
685	Dyslexia	2.3%
686	Duane Retraction Syndrome	2.3%
687	Lateral Medullary Syndrome	2.3%
688	Consciousness Disorders	2.3%
689	Mental Retardation	2.3%
690	Depressed Level of Consciousness	2.3%
691	Mental deficiency	2.3%
692	Intellectual Disability	2.3%
693	Mobius Syndrome	2.3%
694	Bell Palsy	2.3%
695	Marfan Syndrome	2.3%
696	Catatonia	2.3%
697	Herpes Zoster Oticus	2.3%
698	Aphonia	2.2%
699	Sleep Deprivation	2.2%
700	Dysphonia	2.2%
701	Moyamoya Disease	2.2%
702	West Nile Fever	2.2%
703	Hematoma, Subdural	2.1%
704	Hematoma, Epidural, Cranial	2.1%
705	Empty Sella Syndrome	2.1%
706	Hyperpituitarism	2.1%
707	Hypopituitarism	2.1%
708	Hypophysitis	2.1%
709	Radicular Cyst	2.1%
710	Eye Injuries	2.1%
711	Cerebral Arterial Diseases	2.1%
712	Vertebrobasilar Insufficiency	2.1%
713	Anterior Spinal Artery Syndrome	2.1%
714	Basilar Artery Stenosis	2.1%
715	Vertebral Artery Stenosis	2.1%
716	Sleep Apnea, Obstructive	2.1%
717	Sleep Apnea, Central	2.1%
718	Intracranial Hemorrhage, Hypertensive	2.1%
719	Transient Cerebral Ischemia	2.1%
720	Narcolepsy	2.1%
721	Trigeminal Neuralgia	2.1%
722	Kleine-Levin Syndrome	2.1%
723	Agraphia	2.1%
724	Anomia	2.1%
725	Cluttering	2.1%
726	Language Development Disorders	2.1%
727	Speech Disorders	2.1%
728	Syncope	2.1%
729	Stupor	2.1%
730	Dysgraphia	2.1%
731	Presyncope	2.1%
732	Dyslalia	2.1%
733	Congenital nystagmus	2%
734	Diplopia	2%
735	Scotoma	2%
736	Photophobia	2%
737	Hemifacial Spasm	2%
738	Amaurosis	2%
739	Blindness	2%
740	Reye Syndrome	2%
741	Neuroaspergillosis	2%
742	Optic Atrophy, Hereditary, Leber	2%
743	Intracranial Embolism and Thrombosis	2%
744	Hepatic Encephalopathy	2%
745	Agnosia	2%
746	Apraxias	2%
747	Hallucinations	2%
748	Hemianopsia	2%
749	Hyperacusis	2%
750	Tinnitus	2%
751	Visual Agnosia	2%
752	Anosognosia	2%
753	Wernicke-Korsakoff Syndrome	2%
754	Phonophobia	2%
755	Hearing Loss	2%
756	Sarcopenia	2%
757	Nose Neoplasms	1.9%
758	Neuronal Ceroid-Lipofuscinoses	1.9%
759	Hyperprolactinemia	1.9%
760	Hematoma, Subdural, Intracranial	1.9%
761	Hematoma, Subdural, Chronic	1.9%
762	Hematoma, Subdural, Acute	1.9%
763	Subclavian Steal Syndrome	1.9%
764	Pick Disease of the Brain	1.9%
765	Cataplexy	1.9%
766	Aphasia	1.8%
767	Articulation Disorders	1.8%
768	Echolalia	1.8%
769	Stuttering	1.8%
770	Dysphasia	1.8%
771	Renal Osteodystrophy	1.8%
772	Renal rickets	1.8%
773	Pseudorabies	1.8%
774	Dysarthria	1.7%
775	Aicardi's syndrome	1.7%
776	Hoarseness	1.7%
777	Toxoplasmosis, Congenital	1.7%
778	Amnesia	1.7%
779	Delirium	1.7%
780	Dissociative Amnesia	1.7%
781	Color blindness	1.7%
782	Global Amnesia	1.7%
783	Eye Burns	1.7%
784	Cri-du-Chat Syndrome	1.7%
785	Down Syndrome	1.7%
786	Brain Diseases, Metabolic, Inborn	1.7%
787	Trisomy 21	1.7%
788	Malaria, Cerebral	1.7%
789	Alcohol Withdrawal Delirium	1.7%
790	Meningioma	1.7%
791	Williams Syndrome	1.7%
792	Carotid Stenosis	1.7%
793	Intracranial Aneurysm	1.7%
794	Neurocysticercosis	1.7%
795	Amaurosis Fugax	1.7%
796	Blindness, Cortical	1.7%
797	Dyscalculia	1.7%
798	Intracranial Arteriosclerosis	1.7%
799	Cerebral Atherosclerosis	1.7%
800	Rett Syndrome	1.7%
801	Subarachnoid Hemorrhage	1.7%
802	Cerebral Arteriosclerosis	1.7%
803	Cerebral Hemorrhage	1.7%
804	Neurosyphilis	1.6%
805	Cerebral Thrombosis	1.6%
806	Intracranial Embolism	1.6%
807	Intracranial Thrombosis	1.6%
808	Deafness	1.6%
809	Hearing Loss, Sudden	1.6%
810	Gerstmann Syndrome	1.6%
811	Hearing Loss, Bilateral	1.6%
812	Hearing Loss, High-Frequency	1.6%
813	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
814	Prosopagnosia	1.6%
815	Apraxia, Ideomotor	1.6%
816	Charles Bonnet Syndrome	1.6%
817	Hearing Loss, Unilateral	1.6%
818	Complete Hearing Loss	1.6%
819	Alien Hand Syndrome	1.6%
820	Deaf Mutism	1.6%
821	Mutism	1.5%
822	Selective Mutism	1.5%
823	Cerebral Amyloid Angiopathy	1.5%
824	Sinus Thrombosis, Intracranial	1.5%
825	Prader-Willi Syndrome	1.4%
826	Wernicke Encephalopathy	1.4%
827	AIDS Dementia Complex	1.4%
828	Corneal Scar	1.4%
829	Phantom pain	1.4%
830	Phantom Limb Pain	1.4%
831	Waterhouse-Friderichsen Syndrome	1.4%
832	Lyme Neuroborreliosis	1.4%
833	Alexia, Pure	1.4%
834	Cavernous Sinus Thrombosis	1.4%
835	Sagittal Sinus Thrombosis	1.4%
836	Retrograde amnesia	1.4%
837	Amnesia, Anterograde	1.4%
838	Carotid Artery Thrombosis	1.4%
839	Menkes Kinky Hair Syndrome	1.4%
840	Kernicterus	1.3%
841	Corneal Perforation	1.2%
842	Fragile X Syndrome	1.2%
843	Nelson Syndrome	1.2%
844	Prolactinoma	1.1%
845	Growth Hormone-Secreting Pituitary Adenoma	1.1%
846	Fabry Disease	1.1%
847	Familial Hypophosphatemic Rickets	1%
848	Galactosemias	1%
849	Urea Cycle Disorders, Inborn	1%
850	Tyrosinemias	1%
851	Homocystinuria	0.9%
852	Leigh Disease	0.9%
853	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
854	Mucopolysaccharidosis II	0.8%
855	Glycogen storage disease type II	0.7%
856	Zellweger Syndrome	0.7%
857	Gaucher Disease	0.6%
858	Tay-Sachs Disease	0.6%
859	Niemann-Pick Disease, Type C	0.5%

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