MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Carcinoid Heart Disease

(UMLS:C0007093)

Definition:: Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
UMLS ID:: C0007093
MeSH ID:: D002275

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.650.200.500.205|C04.557.470.200.025.200.500.205|C04.557.580.625.650.200.500.205

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.104

Synonym(s)

Carcinoid Heart Disease

Carcinoid heart disease

heart disease secondary to carcinoid tumor

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Octreotide	FAERS: 10 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Octreotide	FAERS: 4	US FAERS
3	Everolimus	FAERS: 1	US FAERS
4	Somatuline Autogel	FAERS: 1	US FAERS
5	lanreotide	FAERS: 1	US FAERS
6	lanreotide	FAERS: 1	US FAERS
7	lanreotide	FAERS: 1 Canada Vigilance: 2	Canada Vigilance US FAERS
8	nintedanib	FAERS: 1	US FAERS
9	telotristat ethyl	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplasms, Neuroepithelial	34.7%
2	Gliomatosis cerebri	34.7%
3	melanoma	30.2%
4	Adenoma, Acidophil	28%
5	Craniopharyngioma	25.5%
6	Neuroectodermal Tumor, Melanotic	25.5%
7	Neurilemmoma	24.9%
8	Paraganglioma	24.8%
9	leukemia	24.5%
10	Basal cell carcinoma	20.6%
11	Carcinoma, Papillary	20.6%
12	Squamous cell carcinoma	20.6%
13	Carcinoma, Basal Cell	20.6%
14	Histiocytic Disorders, Malignant	20.4%
15	Cystadenocarcinoma	20.3%
16	Mucoepidermoid Carcinoma	20.3%
17	Meningioma	19.8%
18	Carcinoma, Ehrlich Tumor	19.7%
19	Carcinoma, Lewis Lung	19.7%
20	Aortic Valve Stenosis	19.6%
21	Cardiomyopathy, Dilated	19.6%
22	Pulmonary Valve Stenosis	19.6%
23	Trophoblastic Neoplasms	18.9%
24	Ganglioneuroma	18.8%
25	Glioma	18.8%
26	Malignant Glioma	18.8%
27	Melanoma, Experimental	18.1%
28	Adenoma	18%
29	Chordoma	18%
30	Teratoma	18%
31	Germinoma	18%
32	Teratocarcinoma	18%
33	Choriocarcinoma	17.9%
34	Carcinoma, Lobular	17.9%
35	Myocardial Ischemia	17.8%
36	Lymphoma	17.5%
37	Myocardial Reperfusion Injury	17.5%
38	Hutchinson's Melanotic Freckle	17.4%
39	Melanoma, Amelanotic	17.4%
40	Tricuspid Atresia	17.2%
41	Arrhythmogenic Right Ventricular Dysplasia	17.2%
42	Hypertrophic Cardiomyopathy	17%
43	Hypertrophic obstructive cardiomyopathy	17%
44	Heart Block	16.9%
45	Tachycardia	16.9%
46	Tachyarrhythmia	16.9%
47	Hamartoma	16.5%
48	Neoplasms, Hormone-Dependent	16.5%
49	Neoplasms, Multiple Primary	16.5%
50	Paraneoplastic Syndromes	16.5%
51	Precancerous Conditions	16.5%
52	Neoplasms, Second Primary	16.5%
53	Neoplasms, Germ Cell and Embryonal	16.3%
54	Neoplasms, Glandular and Epithelial	16.3%
55	Germ Cell Cancer	16.3%
56	Supravalvular aortic stenosis	16.2%
57	Lown-Ganong-Levine Syndrome	16.2%
58	Sick Sinus Syndrome	16.2%
59	Carcinosarcoma	15.8%
60	Hemangiosarcoma	15.8%
61	lymphangiosarcoma	15.8%
62	Cardiac Tamponade	15.8%
63	Endocarditis	15.8%
64	Cardiac Arrest	15.8%
65	Heart failure	15.8%
66	Pericardial effusion	15.8%
67	Pericarditis	15.8%
68	Pneumopericardium	15.8%
69	Cor pulmonale	15.8%
70	Ventricular Outflow Obstruction	15.8%
71	Ventricular Dysfunction	15.8%
72	Cardiomyopathies	15.8%
73	Pleuropericarditis	15.8%
74	Cystadenoma	15.8%
75	Mesothelioma	15.8%
76	Composite Lymphoma	15.6%
77	Carcinoma in Situ	15.3%
78	Carcinoma, Transitional Cell	15.3%
79	Carcinoma, Large Cell	15.3%
80	Carcinoma, Small Cell	15.3%
81	Medulloblastoma	15.2%
82	Adenoid Cystic Carcinoma	14.9%
83	Adenocarcinoma, Clear Cell	14.9%
84	Cholangiocarcinoma	14.9%
85	Pheochromocytoma	14.8%
86	Leukemia, Experimental	14.8%
87	Dermoid Cyst	14.8%
88	Long QT Syndrome	14.7%
89	Neuroectodermal Tumors	13.9%
90	Cyst	13.9%
91	Neoplastic Processes	13.9%
92	Neoplastic Syndromes, Hereditary	13.9%
93	Pregnancy Complications, Neoplastic	13.9%
94	Adams-Stokes Syndrome	13.8%
95	Atrioventricular Block	13.8%
96	Bundle-Branch Block	13.8%
97	Atrial Premature Complexes	13.8%
98	Sinoatrial Block	13.8%
99	Tachycardia, Paroxysmal	13.8%
100	Supraventricular tachycardia	13.8%
101	Tachycardia, Ventricular	13.8%
102	Wolff-Parkinson-White Syndrome	13.8%
103	Tachycardia, Reciprocating	13.8%
104	Neoplasms, Experimental	13.7%
105	Leukemia, Plasma Cell	13.6%
106	Cardiac Output, High	13.4%
107	Myocardial Stunning	13.4%
108	Low Cardiac Output Syndrome	13.4%
109	Cardiomegaly	13.2%
110	Postpericardiotomy Syndrome	13.2%
111	Cardiac Hypertrophy	13.2%
112	Retinoblastoma	13.1%
113	Carcinoma 256, Walker	13.1%
114	Rheumatic Heart Disease	13.1%
115	Leukemia, Radiation-Induced	13.1%
116	Coronary heart disease	13.1%
117	Myocardial Infarction	13.1%
118	Acute Coronary Syndrome	13.1%
119	Ameloblastoma	12.4%
120	Angiokeratoma	12.4%
121	Hemangioma	12.4%
122	hemangiopericytoma	12.4%
123	Lymphangioma	12.4%
124	Mesenchymoma	12.4%
125	Nevus	12.4%
126	Hepatoblastoma	12.4%
127	Mixed Tumor, Mullerian	12.4%
128	Angiofibroma	12.4%
129	Sarcoma	12.4%
130	Tachycardia, Atrioventricular Nodal Reentry	12.4%
131	Tachycardia, Ectopic Atrial	12.4%
132	Tachycardia, Ectopic Junctional	12.4%
133	Sinus Tachycardia	12.4%
134	Torsades de Pointes	12.4%
135	Accelerated Idioventricular Rhythm	12.4%
136	Romano-Ward Syndrome	12.1%
137	Coronary Aneurysm	12.1%
138	Neoplasms, Radiation-Induced	11.8%
139	Aortic Valve Insufficiency	11.7%
140	Restrictive cardiomyopathy	11.7%
141	Endocardial Fibroelastosis	11.7%
142	Heart Rupture, Post-Infarction	11.7%
143	Mitral Valve Insufficiency	11.7%
144	Mitral Valve Stenosis	11.7%
145	Myocarditis	11.7%
146	Pericarditis, Constrictive	11.7%
147	Pulmonary Valve Insufficiency	11.7%
148	Tricuspid Valve Insufficiency	11.7%
149	Tricuspid Valve Stenosis	11.7%
150	Ventricular Dysfunction, Left	11.7%
151	Right Ventricular Dysfunction	11.7%
152	Endomyocardial Fibrosis	11.7%
153	Carditis	11.7%
154	Heart Failure, Systolic	11.7%
155	Heart Failure, Diastolic	11.7%
156	Multiple Endocrine Neoplasia	11.6%
157	Coronary Thrombosis	11.5%
158	Coronary Artery Disease	11.5%
159	Bowen's Disease	11.4%
160	Acanthoma	11.4%
161	Kounis Syndrome	11.3%
162	Aortic coarctation	11.2%
163	Cor Triatriatum	11.2%
164	Coronary Vessel Anomalies	11.2%
165	Patent ductus arteriosus	11.2%
166	Ebstein Anomaly	11.2%
167	Heart Septal Defects	11.2%
168	Tetralogy of Fallot	11.2%
169	Transposition of Great Vessels	11.2%
170	Hypoplastic Left Heart Syndrome	11.2%
171	Angina Pectoris	11.2%
172	Astrocytoma	10.9%
173	Ependymoma	10.9%
174	oligodendroglioma	10.9%
175	Ganglioglioma	10.9%
176	gliosarcoma	10.9%
177	Anaplastic astrocytoma	10.9%
178	Anaplastic Oligodendroglioma	10.9%
179	Chondrosarcoma	10.9%
180	leiomyosarcoma	10.9%
181	liposarcoma	10.9%
182	synovial sarcoma	10.9%
183	Angiomyolipoma	10.9%
184	Clear Cell Sarcoma of Soft Tissue	10.9%
185	Alveolar Soft Part Sarcoma	10.9%
186	Sarcoma, Myeloid	10.9%
187	Bacterial Endocarditis	10.9%
188	Coronary Occlusion	10.8%
189	Microvascular Angina	10.8%
190	Coronary Stenosis	10.8%
191	ST segment elevation myocardial infarction	10.8%
192	Sarcoma, Experimental	10.5%
193	Thymoma	10.5%
194	Plasmacytoma	10.4%
195	Malignant histiocytosis	10.4%
196	Histiocytic sarcoma	10.4%
197	Endometrial Stromal Sarcoma	9.9%
198	Dextrocardia	9.8%
199	Sinus Arrhythmia	9.8%
200	Atrial Fibrillation	9.8%
201	Atrial Flutter	9.8%
202	Edema, Cardiac	9.8%
203	Ventricular Fibrillation	9.8%
204	Ventricular Flutter	9.8%
205	Parasystole	9.8%
206	Paroxysmal atrial fibrillation	9.8%
207	Bradycardia	9.8%
208	Diabetic Cardiomyopathies	9.8%
209	Cardiomyopathy, Alcoholic	9.7%
210	Sudden Cardiac Death	9.7%
211	Left Ventricular Hypertrophy	9.7%
212	Right Ventricular Hypertrophy	9.7%
213	Chagas Cardiomyopathy	9.7%
214	Aortic Valve Prolapse	9.7%
215	Tricuspid Valve Prolapse	9.7%
216	Takotsubo Cardiomyopathy	9.7%
217	Adenofibroma	9.7%
218	Fibroadenoma	9.7%
219	Coronary Restenosis	9.6%
220	Tuberous Sclerosis	9.6%
221	Acoustic Neuroma	9.5%
222	Dysgerminoma	9.5%
223	Neuroma	9.5%
224	Papilloma	9.5%
225	Pseudomyxoma Peritonei	9.5%
226	Seminoma	9.5%
227	Papillomatosis	9.5%
228	Adenomatosis, Pulmonary	9.5%
229	Adenomatous Polyps	9.5%
230	Shock, Cardiogenic	9.3%
231	Aortopulmonary Septal Defect	9.2%
232	Double Outlet Right Ventricle	9.2%
233	Endocardial Cushion Defects	9.2%
234	Myocardial bridging	9.2%
235	Aorticopulmonary Septal Defect	9.2%
236	Angina, Unstable	9.2%
237	Vipoma	9.2%
238	Nephroblastoma	9.1%
239	Paraneoplastic Encephalomyelitis	8.9%
240	Adrenocortical carcinoma	8.9%
241	Leukemia L1210	8.9%
242	Leukemia P388	8.9%
243	Klatskin Tumor	8.9%
244	Basal Cell Nevus Syndrome	8.9%
245	Hodgkin Disease	8.9%
246	Lymphoma, Non-Hodgkin	8.9%
247	Mammary Neoplasms, Experimental	8.8%
248	Carcinoma, Ovarian Epithelial	8.7%
249	Carcinoma, Pancreatic Ductal	8.5%
250	Fibrosarcoma	8.5%
251	Osteosarcoma	8.5%
252	Cervical Intraepithelial Neoplasia	8.5%
253	Dyspnea, Paroxysmal	8.4%
254	Carcinoma	8.3%
255	Epithelioma	8.3%
256	Truncus Arteriosus, Persistent	8.2%
257	Angina Pectoris, Variant	8.2%
258	Waldenstrom Macroglobulinemia	8.2%
259	Multiple Myeloma	8.2%
260	Lymphangioleiomyomatosis	8.2%
261	Abdominal Neoplasms	8.2%
262	Erythroplasia	8.2%
263	Follicular cyst	8.2%
264	Head and Neck Neoplasms	8.2%
265	Mucocele	8.2%
266	Pilonidal Cyst	8.2%
267	Soft Tissue Neoplasms	8.2%
268	Thoracic Neoplasms	8.2%
269	Thyroglossal Cyst	8.2%
270	Synovial Cyst	8.2%
271	Aberrant Crypt Foci	8.2%
272	Vascular Diseases	8.1%
273	Sinus Arrest, Cardiac	8.1%
274	Renal Cell Carcinoma	8%
275	Papillary Renal Cell Carcinoma	8%
276	Vascular Neoplasms	7.9%
277	Noonan Syndrome	7.9%
278	Primary amyloidosis	7.8%
279	Carcinoma, Endometrioid	7.8%
280	Subacute Bacterial Endocarditis	7.6%
281	Sturge-Weber Syndrome	7.6%
282	Hemangioma, Cavernous	7.5%
283	Hepatocellular Adenoma	7.3%
284	Lymphomatoid Granulomatosis	7.3%
285	Neuroendocrine Tumors	7.3%
286	Marfan Syndrome	7.3%
287	Nasopharyngeal carcinoma	7.3%
288	Malignant Fibrous Histiocytoma	7.2%
289	Arteriovenous fistula	7.1%
290	Digestive System Neoplasms	7%
291	Endocrine Gland Neoplasms	7%
292	Eye Neoplasms	7%
293	Nervous System Neoplasms	7%
294	Glioblastoma	7%
295	Neuroblastoma	7%
296	Glioblastoma Multiforme	7%
297	Bone neoplasms	6.9%
298	Leukoplakia	6.9%
299	Lymphocele	6.9%
300	Pancreatic Cyst	6.9%
301	Skin Neoplasms	6.9%
302	Hematologic Neoplasms	6.9%
303	Pregnancy Complications, Cardiovascular	6.8%
304	Cardiovascular Abnormalities	6.8%
305	Barrett Esophagus	6.8%
306	Breast Cyst	6.8%
307	Actinic keratosis	6.8%
308	Mediastinal Cyst	6.8%
309	Neoplasm Invasiveness	6.8%
310	Neoplasm Metastasis	6.8%
311	Neoplasm Recurrence, Local	6.8%
312	Parovarian Cyst	6.8%
313	Pericardial Cyst	6.8%
314	Splenic Neoplasms	6.8%
315	Thymic Cyst	6.8%
316	Carcinogenesis	6.8%
317	Myxoid cyst	6.8%
318	Metastasis	6.8%
319	Mesoblastic Nephroma	6.8%
320	neurofibroma	6.7%
321	Thrombophlebitis	6.7%
322	Phyllodes Tumor	6.5%
323	Hemangioendothelioma	6.5%
324	Lipoma	6.5%
325	Myoma	6.5%
326	Myxoma	6.5%
327	Angiolipoma	6.5%
328	Myelolipoma	6.5%
329	Neoplasms, Bone Tissue	6.5%
330	Neoplasms, Fibrous Tissue	6.5%
331	Smooth Muscle Tumor	6.5%
332	Desmoplastic Small Round Cell Tumor	6.5%
333	Chondroma	6.5%
334	Enchondroma	6.5%
335	Aortic Aneurysm	6.5%
336	Aortitis	6.5%
337	Leriche Syndrome	6.5%
338	Periphlebitis	6.5%
339	Phlebitis	6.5%
340	Thromboangiitis Obliterans	6.5%
341	Prolactinoma	6.5%
342	Growth Hormone-Secreting Pituitary Adenoma	6.5%
343	Sarcoma 180	6.5%
344	Optic Nerve Glioma	6.2%
345	Aortic Rupture	6.1%
346	Embolism, Amniotic Fluid	6.1%
347	Neurofibrosarcoma	6.1%
348	Rhabdomyosarcoma	6%
349	Giant Cell Tumor of Bone	6%
350	Postphlebitic Syndrome	6%
351	Retinal Vein Occlusion	5.9%
352	Multiple Endocrine Neoplasia Type 1	5.9%
353	Carotid Artery Thrombosis	5.8%
354	Corpus Luteum Cyst	5.8%
355	Ovarian Cysts	5.8%
356	Liver Neoplasms, Experimental	5.8%
357	Gastrinoma	5.7%
358	Glucagonoma	5.7%
359	Malignant Atrophic Papulosis	5.6%
360	Shwartzman Phenomenon	5.6%
361	May-Thurner Syndrome	5.6%
362	Moyamoya Disease	5.5%
363	Blue Toe Syndrome	5.5%
364	Williams Syndrome	5.5%
365	Leukemia, Myelomonocytic, Chronic	5.5%
366	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.5%
367	Aortic Aneurysm, Abdominal	5.4%
368	Aortic Aneurysm, Thoracic	5.4%
369	Adenomatous Polyposis Coli	5.4%
370	Parathyroid Neoplasms	5.3%
371	Peritoneal Neoplasms	5.3%
372	Thyroid Neoplasm	5.3%
373	Thyroid carcinoma	5.3%
374	Hydatidiform Mole	5.3%
375	Aneurysm	5.3%
376	Angiomatosis	5.3%
377	Aortic Diseases	5.3%
378	Arterial Occlusive Diseases	5.3%
379	Hyperemia	5.3%
380	Hypotension	5.3%
381	Superior Vena Cava Syndrome	5.3%
382	Telangiectasis	5.3%
383	Vasculitis	5.3%
384	Venous Insufficiency	5.3%
385	Peripheral Vascular Diseases	5.3%
386	Embolism and Thrombosis	5.3%
387	Angiodysplasia	5.3%
388	Capillary Leak Syndrome	5.3%
389	Prehypertension	5.3%
390	Choledochal Cyst	5.2%
391	Carcinoid Tumor	5.2%
392	Intracranial Embolism and Thrombosis	5.1%
393	Carotid Stenosis	5.1%
394	Intracranial Aneurysm	5.1%
395	Ganglioneuroblastoma	5.1%
396	Peutz-Jeghers Syndrome	5.1%
397	Dermatofibrosarcoma	4.8%
398	Dermatofibrosarcoma Protuberans	4.8%
399	Pancreatic Neoplasm	4.8%
400	Mastocytosis	4.8%
401	Gastrointestinal Stromal Tumors	4.7%
402	Scimitar Syndrome	4.7%
403	Leukemia, T-Cell	4.7%
404	Leukemia, B-Cell	4.7%
405	Lymphoma, Follicular	4.7%
406	T-Cell Lymphoma	4.7%
407	Mantle cell lymphoma	4.7%
408	Polyarteritis Nodosa	4.6%
409	Takayasu Arteritis	4.6%
410	Intracranial Arteriosclerosis	4.6%
411	Cerebral Atherosclerosis	4.6%
412	Cerebral Arteriosclerosis	4.6%
413	Vascular System Injuries	4.6%
414	Turner Syndrome	4.5%
415	Compartment syndromes	4.5%
416	Hepatic Veno-Occlusive Disease	4.5%
417	Peliosis Hepatis	4.5%
418	Varicocele	4.5%
419	Giant Cell Arteritis	4.4%
420	Temporal Arteritis	4.4%
421	Cerebrovascular Disorders	4.4%
422	Diabetic Angiopathies	4.4%
423	Reperfusion Injury	4.4%
424	Splenic Infarction	4.4%
425	Cerebrovascular Insufficiency	4.4%
426	Spinal Cord Vascular Diseases	4.4%
427	Vasoplegia	4.4%
428	Vasculitis, Central Nervous System	4.4%
429	Hemorrhoids	4.4%
430	Thoracic Outlet Syndrome	4.4%
431	Adenocarcinoma	4.4%
432	Cerebral Thrombosis	4.4%
433	Intracranial Embolism	4.4%
434	Intracranial Thrombosis	4.4%
435	granulosa cell tumor	4.4%
436	Lemierre Syndrome	4.3%
437	Retroperitoneal Neoplasms	4.1%
438	Kartagener Syndrome	4.1%
439	Kearns-Sayre syndrome	4.1%
440	Infarction, Middle Cerebral Artery	4.1%
441	Infarction, Anterior Cerebral Artery	4.1%
442	Infarction, Posterior Cerebral Artery	4.1%
443	Subarachnoid Hemorrhage, Traumatic	4.1%
444	Carotid Artery, Internal, Dissection	4.1%
445	Tracheal Neoplasms	4.1%
446	Brain Infarction	4%
447	Sinus Thrombosis, Intracranial	4%
448	Leukoplakia, Oral	4%
449	Paraneoplastic Cerebellar Degeneration	4%
450	Aneurysm, Dissecting	3.9%
451	Arteriosclerosis	3.9%
452	Arteritis	3.9%
453	Embolism	3.9%
454	Erythromelalgia	3.9%
455	Fibromuscular Dysplasia	3.9%
456	Malignant Hypertension	3.9%
457	Raynaud Disease	3.9%
458	Thromboembolism	3.9%
459	Thrombosis	3.9%
460	Essential Hypertension	3.9%
461	Aneurysm, Ruptured	3.9%
462	Iliac Aneurysm	3.9%
463	Pulmonary artery stenosis	3.9%
464	White Coat Hypertension	3.9%
465	Systemic Vasculitis	3.9%
466	Embolus	3.9%
467	Hand-Arm Vibration Syndrome	3.9%
468	Cavernous Sinus Thrombosis	3.8%
469	Sagittal Sinus Thrombosis	3.8%
470	insulinoma	3.8%
471	Optic Neuropathy, Ischemic	3.8%
472	Anterior Ischemic Optic Neuropathy	3.8%
473	Mesenteric vascular insufficiency	3.8%
474	Angioedema	3.7%
475	Colitis, Ischemic	3.7%
476	fibroma	3.6%
477	Fibromatosis	3.6%
478	Osteoblastoma	3.6%
479	Osteoma	3.6%
480	Rhabdomyoma	3.6%
481	Chondromatosis	3.6%
482	Hemangioblastoma	3.6%
483	Lymphoma, Extranodal NK-T-Cell	3.6%
484	Vertebral Artery Dissection	3.6%
485	Alveolar rhabdomyosarcoma	3.6%
486	Cerebral Infarction	3.6%
487	Brain Stem Infarctions	3.6%
488	CREST Syndrome	3.6%
489	Esophageal Neoplasms	3.6%
490	Denys-Drash Syndrome	3.5%
491	Limbic Encephalitis	3.5%
492	Mouth Neoplasms	3.5%
493	Central Nervous System Neoplasms	3.5%
494	Thymus Neoplasms	3.5%
495	Genital Neoplasms, Female	3.5%
496	Pancreatic Pseudocyst	3.5%
497	Lymphatic Metastasis	3.5%
498	Neoplasms, Unknown Primary	3.5%
499	Leukemic Infiltration	3.5%
500	Breast Neoplasms, Male	3.5%
501	Neoplasm Micrometastasis	3.5%
502	Triple Negative Breast Neoplasms	3.5%
503	Xeroderma Pigmentosum	3.4%
504	Lateral Medullary Syndrome	3.4%
505	Retinal Artery Occlusion	3.3%
506	Retinal Vasculitis	3.3%
507	Hypertensive Retinopathy	3.3%
508	Anterior Compartment Syndrome	3.3%
509	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
510	Gastric Antral Vascular Ectasia	3.3%
511	Abdominal Compartment Syndrome	3.3%
512	Carotid Artery Diseases	3.2%
513	Brain Ischemia	3.2%
514	Ectopia Cordis	3.2%
515	Hypotension, Orthostatic	3.2%
516	Cerebrovascular accident	3.2%
517	Varicose Ulcer	3.2%
518	Vasospasm, Intracranial	3.2%
519	Spinal Cord Ischemia	3.2%
520	Intracranial Arterial Diseases	3.2%
521	Primary Graft Dysfunction	3.2%
522	Single umbilical artery	3.2%
523	Post-Exercise Hypotension	3.2%
524	Carotid Artery Injuries	3.2%
525	Arteriosclerosis Obliterans	3.2%
526	Atherosclerosis	3.2%
527	Air Embolism	3.2%
528	Endarteritis	3.2%
529	Venous Thrombosis	3.2%
530	Deep Vein Thrombosis	3.2%
531	Venous Thromboembolism	3.2%
532	Lambert-Eaton Myasthenic Syndrome	3.2%
533	Testicular Neoplasms	3.2%
534	Malignant Carcinoid Syndrome	3.1%
535	Basal Ganglia Hemorrhage	3%
536	Adrenal Gland Neoplasms	3%
537	Gastrointestinal Neoplasms	3%
538	Genital Neoplasms, Male	3%
539	Liver neoplasms	3%
540	Uveal Neoplasms	3%
541	Mastocytoma	3%
542	Mastocytosis, Systemic	3%
543	Leukemia, Myeloid, Chronic-Phase	3%
544	Urologic Neoplasms	3%
545	Sebaceous Gland Neoplasms	3%
546	Spinal Neoplasms	3%
547	Bone Marrow Neoplasms	3%
548	Polycystic Ovary Syndrome	2.9%
549	Opsoclonus-Myoclonus Syndrome	2.9%
550	Mesenteric Vascular Occlusion	2.8%
551	Mucocutaneous Lymph Node Syndrome	2.8%
552	Diabetic Retinopathy	2.8%
553	Livedo Reticularis	2.8%
554	Renal hypertension	2.8%
555	Renal Artery Obstruction	2.8%
556	Renal Artery Stenosis	2.8%
557	Putaminal Hemorrhage	2.8%
558	Basal Ganglia Cerebrovascular Disease	2.8%
559	Vascular Headaches	2.8%
560	Scurvy	2.8%
561	Thyroid Nodule	2.7%
562	Intermittent Claudication	2.7%
563	Pulmonary Embolism	2.7%
564	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.7%
565	No-Reflow Phenomenon	2.7%
566	Cerebral Arterial Diseases	2.7%
567	Vertebrobasilar Insufficiency	2.7%
568	Anterior Spinal Artery Syndrome	2.7%
569	Basilar Artery Stenosis	2.7%
570	Vertebral Artery Stenosis	2.7%
571	Intracranial Hemorrhage, Hypertensive	2.7%
572	Transient Cerebral Ischemia	2.7%
573	Myelitis, Transverse	2.7%
574	Dementia, Vascular	2.6%
575	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
576	Leukemia, Large Granular Lymphocytic	2.6%
577	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.6%
578	Lymphoma, T-Cell, Cutaneous	2.6%
579	Lymphoma, AIDS-Related	2.6%
580	Enteropathy-Associated T-Cell Lymphoma	2.6%
581	Primary Effusion Lymphoma	2.6%
582	Leydig Cell Tumor	2.5%
583	Dural Arteriovenous Fistula	2.5%
584	Ischemic contracture	2.5%
585	Hepatic Vein Thrombosis	2.5%
586	Budd-Chiari Syndrome	2.5%
587	Angioedemas, Hereditary	2.5%
588	Cryoglobulinemia	2.4%
589	Leukomalacia, Periventricular	2.4%
590	Pulmonary Infarction	2.4%
591	Diabetic Foot	2.4%
592	Subclavian Steal Syndrome	2.4%
593	ovarian neoplasm	2.3%
594	Hypertension, Renovascular	2.3%
595	Subarachnoid Hemorrhage	2.3%
596	Hypoxia-Ischemia, Brain	2.3%
597	Cerebral Hemorrhage	2.3%
598	Hereditary Angioedema Type III	2.3%
599	Hereditary Angioedema Types I and II	2.3%
600	Fibromatosis, Aggressive	2.2%
601	Fibromatosis, Abdominal	2.2%
602	Shy-Drager Syndrome	2.2%
603	Purpura, Hyperglobulinemic	2.2%
604	Lupus Vasculitis, Central Nervous System	2.2%
605	Granulomatosis with polyangiitis	2.1%
606	Cerebral Amyloid Angiopathy	2.1%
607	Nose Neoplasms	2.1%
608	Pituitary Apoplexy	2%
609	Burkitt Lymphoma	2%
610	Behcet Syndrome	2%
611	Pituitary Adenoma	1.9%
612	Pituitary Neoplasms	1.9%
613	Zollinger-Ellison syndrome	1.9%
614	Meningeal Neoplasms	1.8%
615	Carcinoid Heart Disease	1.8%
616	Ataxia Telangiectasia	1.8%
617	Rheumatoid Vasculitis	1.8%
618	Pseudoxanthoma Elasticum	1.8%
619	Palatal Neoplasms	1.7%
620	Ear Neoplasms	1.6%
621	Eyelid Neoplasms	1.6%
622	Lung Neoplasms	1.6%
623	Pleural Neoplasms	1.6%
624	Dupuytren Contracture	1.6%
625	Cell Transformation, Viral	1.6%
626	Brain Neoplasms	1.6%
627	Salivary Gland Neoplasms	1.6%
628	Spinal Cord Neoplasms	1.6%
629	Tongue Neoplasms	1.6%
630	Urticaria Pigmentosa	1.6%
631	Uterine Neoplasms	1.6%
632	Vaginal Neoplasms	1.6%
633	Vulvar Neoplasms	1.6%
634	Uterine Cancer	1.6%
635	Fallopian Tube Neoplasms	1.6%
636	Mycosis Fungoides	1.5%
637	Lymphomatoid Papulosis	1.5%
638	Plasmablastic lymphoma	1.5%
639	Hematoma, Subdural	1.4%
640	Hematoma, Epidural, Cranial	1.4%
641	Pharyngeal Neoplasms	1.4%
642	Central Nervous System Cysts	1.4%
643	Bile Duct Neoplasms	1.4%
644	gallbladder neoplasm	1.4%
645	Intestinal Neoplasms	1.4%
646	Penile Neoplasms	1.4%
647	Prostatic Neoplasms	1.4%
648	Stomach Neoplasms	1.4%
649	Polycythemia Vera	1.4%
650	Hematoma, Subdural, Intracranial	1.4%
651	Hematoma, Subdural, Chronic	1.4%
652	Hematoma, Subdural, Acute	1.4%
653	Brain Hemorrhage, Traumatic	1.3%
654	Laryngeal neoplasm	1.3%
655	MELAS Syndrome	1.2%
656	Bladder Neoplasm	1.2%
657	Kidney Neoplasm	1.2%
658	Ureteral Neoplasms	1.2%
659	Urethral Neoplasms	1.2%
660	Sezary Syndrome	1.2%
661	Meningeal Carcinomatosis	1%
662	Fabry Disease	1%
663	Bronchial Neoplasms	0.9%
664	Multiple Pulmonary Nodules	0.9%
665	Supratentorial Neoplasms	0.9%
666	Endometrial Neoplasms	0.9%
667	Hypopharyngeal Neoplasms	0.8%
668	Pleural Effusion, Malignant	0.8%
669	Hypopharyngeal Cancer	0.8%
670	Parotid Neoplasms	0.8%
671	Prostatic Neoplasms, Castration-Resistant	0.8%
672	Nelson Syndrome	0.8%
673	Cecal Neoplasms	0.7%
674	Duodenal Neoplasms	0.7%
675	Nasopharyngeal Neoplasms	0.6%
676	Colorectal Neoplasms	0.6%
677	Paranasal Sinus Neoplasms	0.6%
678	Brain Stem Neoplasms	0.5%
679	Tonsillar Neoplasms	0.5%
680	Cerebellar Neoplasms	0.5%
681	Radicular Cyst	0.4%
682	Appendiceal Neoplasms	0.4%
683	Colonic Neoplasms	0.4%
684	Rectal Neoplasms	0.4%
685	Choroid Plexus Papilloma	0.3%
686	Maxillary Sinus Neoplasms	0.3%
687	Anus Neoplasms	0.2%
688	Sigmoid Neoplasms	0.2%

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