MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Macrocephaly

(UMLS:C0221355)

Definition:: A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with HYDROCEPHALUS; SUBDURAL EFFUSION; ARACHNOID CYSTS; or is part of a genetic condition (e.g., ALEXANDER DISEASE; SOTOS SYNDROME).
UMLS ID:: C0221355
MeSH ID:: D058627

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.207.536

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.507.400.249

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.532|C16.131.666.507.400.249

Synonym(s)

Macrocephaly

Macrencephaly

Macrocephalus

Macroencephaly

Megacephaly

Megalencephaly

Megalocephaly

congenital deformity of head macrocephaly

macrencephaly

10.

macrocephalus

11.

macrocephaly

12.

macroencephaly

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 13	US FAERS
2	Sertraline	FAERS: 5	US FAERS
3	Valproic Acid	FAERS: 5	US FAERS
4	Ondansetron	FAERS: 3	US FAERS
5	Valproic Acid	FAERS: 3	US FAERS
6	Fluoxetine	FAERS: 2	US FAERS
7	Levetiracetam	FAERS: 2	US FAERS
8	Oseltamivir	FAERS: 2	US FAERS
9	17 alpha-Hydroxyprogesterone Caproate	FAERS: 1	US FAERS
10	Amoxicillin	FAERS: 1	US FAERS
11	Buprenorphine	FAERS: 1	US FAERS
12	Citalopram	FAERS: 1	US FAERS
13	Citalopram	FAERS: 1	US FAERS
14	Clozapine	FAERS: 1	US FAERS
15	Lamotrigine	FAERS: 1	US FAERS
16	Methylphenidate	FAERS: 1	US FAERS
17	Metoclopramide	FAERS: 1	US FAERS
18	Nevirapine	FAERS: 1	US FAERS
19	Paroxetine	FAERS: 1	US FAERS
20	Promethazine	FAERS: 1	US FAERS
21	Sodium iodide I 131	FAERS: 1	US FAERS
22	Thyroxine	FAERS: 1	US FAERS
23	Topiramate	FAERS: 1	US FAERS
24	Valproic Acid	FAERS: 1	US FAERS
25	Warfarin	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Microcephaly	51.8%
2	Holoprosencephaly	37.7%
3	Craniosynostosis	34.5%
4	Brachycephaly	34.5%
5	Plagiocephaly	33.9%
6	Maxillofacial Abnormalities	32.6%
7	Porencephaly	32.2%
8	Rubinstein-Taybi Syndrome	31.5%
9	Craniofacial Dysostosis	30.4%
10	Platybasia	28.8%
11	Acrocephalosyndactylia	27.1%
12	Limb Deformities, Congenital	25.6%
13	Arthrogryposis	24.6%
14	Noonan Syndrome	24.1%
15	Pectus excavatum	23.9%
16	Klippel-Feil Syndrome	23.3%
17	Synostosis	23.3%
18	Syndactyly	22.9%
19	Hydranencephaly	22.9%
20	Neural Tube Defects	22.9%
21	Tethered Cord Syndrome	22.9%
22	Iniencephaly	22.9%
23	Craniorachischisis	22.9%
24	Exencephaly	22.9%
25	Septo-Optic Dysplasia	22.9%
26	Classical Lissencephalies and Subcortical Band Heterotopias	22.3%
27	Gastroschisis	21.9%
28	Tuberous Sclerosis	21.8%
29	Aicardi's syndrome	21.6%
30	Dural Arteriovenous Fistula	21.4%
31	Pectus carinatum	21%
32	Jaw Abnormalities	20.8%
33	Mandibulofacial Dysostosis	19.8%
34	Anencephaly	19.6%
35	Abnormalities, Drug-Induced	18.8%
36	Situs Inversus	18.8%
37	Dandy-Walker Syndrome	18.7%
38	Goldenhar Syndrome	18.6%
39	Central Nervous System Cysts	18.4%
40	Beckwith-Wiedemann Syndrome	18%
41	Wolf-Hirschhorn Syndrome	18%
42	Smith-Magenis syndrome	18%
43	Lissencephaly	18%
44	Polymicrogyria	18%
45	Pachygyria	18%
46	Schizencephaly	18%
47	Periventricular Nodular Heterotopia	18%
48	Poland Syndrome	16.9%
49	Cri-du-Chat Syndrome	16.6%
50	Down Syndrome	16.6%
51	Trisomy 21	16.6%
52	Amelia	16.5%
53	Arachnodactyly	16.5%
54	Ectromelia	16.5%
55	Hemimelia	16.5%
56	Phocomelia	16.5%
57	Sirenomelia	16.5%
58	Polydactyly	16.5%
59	Brachydactyly	16.5%
60	Lower Extremity Deformities, Congenital	16.5%
61	Upper Extremity Deformities, Congenital	16.5%
62	Eye Abnormalities	16.2%
63	Cardiovascular Abnormalities	16.2%
64	Micrognathism	16.2%
65	Pierre Robin Syndrome	16.2%
66	Skin Abnormalities	15.9%
67	Lymphatic Abnormalities	15.9%
68	Congenital Microtia	15.9%
69	Congenital diaphragmatic hernia	15.6%
70	Cleft Palate	15.1%
71	Retrognathia	14.7%
72	Prader-Willi Syndrome	14.7%
73	Prognathism	14.6%
74	Ectodermal Dysplasia	14.1%
75	Aplasia Cutis Congenita	14.1%
76	Urogenital Abnormalities	14%
77	Meningomyelocele	13.8%
78	Spina Bifida	13.8%
79	Nail-Patella Syndrome	13.4%
80	Antley-Bixler Syndrome Phenotype	13.1%
81	Alstrom Syndrome	13%
82	Laryngomalacia	12.9%
83	CHARGE Syndrome	12.3%
84	Marfan Syndrome	12.3%
85	Mobius Syndrome	12%
86	Meningocele	11.9%
87	Encephalocele	11.9%
88	Genetic Diseases, Inborn	11.9%
89	Charcot-Marie-Tooth Disease	11.7%
90	Kartagener Syndrome	11.4%
91	Dextrocardia	11%
92	Cockayne Syndrome	11%
93	Xeroderma	10.8%
94	Prune Belly Syndrome	10.7%
95	Twins, Conjoined	10.7%
96	Waardenburg Syndrome	10.7%
97	Talipes	10.7%
98	Abnormalities, Radiation-Induced	10.4%
99	Fetal Diseases	10%
100	Williams Syndrome	9.8%
101	Dermal Sinus	9.4%
102	Spina Bifida Cystica	9.4%
103	Spina Bifida Occulta	9.4%
104	Bronchomalacia	9.2%
105	Tracheomalacia	9.2%
106	Anophthalmos	9.1%
107	Anus, Imperforate	9.1%
108	Microphthalmos	9.1%
109	Anorectal Malformations	9.1%
110	Scimitar Syndrome	9%
111	Congenital clubfoot	9%
112	Vertical Talus	9%
113	Bloom Syndrome	9%
114	Polycystic Kidney Diseases	8.9%
115	Refsum Disease	8.8%
116	Myopathy	8.5%
117	Retinal Dysplasia	8.2%
118	Aniridia	8.2%
119	Cystic Fibrosis	8.1%
120	Fragile X Syndrome	8.1%
121	Epidermolysis Bullosa	8%
122	Blepharophimosis	7.9%
123	Laryngostenosis	7.9%
124	Mouth Abnormalities	7.9%
125	Esophageal Atresia	7.8%
126	Intestinal Atresia	7.8%
127	Horseshoe Kidney	7.8%
128	Acrodermatitis	7.7%
129	Lymphangiectasis, Intestinal	7.7%
130	Gianotti-Crosti Syndrome	7.7%
131	Ichthyosis, X-Linked	7.7%
132	Smith-Lemli-Opitz Syndrome	7.6%
133	POEMS Syndrome	7.5%
134	Multiple Epiphyseal Dysplasia	7.4%
135	Osteochondrodysplasias	7.4%
136	Muscular Dystrophy	7.3%
137	Basal Cell Nevus Syndrome	7.3%
138	Myotonic Dystrophy	7.3%
139	Fibromyalgia	7.2%
140	Meconium Aspiration Syndrome	7.1%
141	Choanal Atresia	6.9%
142	Tracheobronchomegaly	6.9%
143	Laryngocele	6.9%
144	Choledochal Cyst	6.9%
145	Hermaphroditism	6.9%
146	Disorders of Sex Development	6.9%
147	Myasthenic Syndromes, Congenital	6.9%
148	Primary Ciliary Dyskinesia	6.9%
149	Cryptorchidism	6.8%
150	Hypospadias	6.8%
151	Bone Diseases	6.8%
152	Fasciitis	6.8%
153	Foot Deformities	6.8%
154	Arthropathy	6.8%
155	Turner Syndrome	6.7%
156	Contracture	6.7%
157	Osteoarthropathy, Secondary Hypertrophic	6.7%
158	Fasciitis, Plantar	6.7%
159	Pseudoxanthoma Elasticum	6.6%
160	Dwarfism	6.6%
161	Gout	6.4%
162	Muscular Dystrophy, Duchenne	6.3%
163	Abdominal Cramps	6.3%
164	Amniotic Band Syndrome	6.3%
165	Asphyxia Neonatorum	6.3%
166	Infant, Premature, Diseases	6.3%
167	Infantile Colic	6.3%
168	Cranial nerve diseases	6.1%
169	Demyelinating Diseases	6.1%
170	Demyelination	6.1%
171	Neuromuscular Diseases	6.1%
172	Chronobiology Disorders	6.1%
173	Xeroderma Pigmentosum	6.1%
174	Bladder Exstrophy	6.1%
175	Epispadias	6.1%
176	Multicystic Dysplastic Kidney	6%
177	Chronic Fatigue Syndrome	6%
178	Sjogren-Larsson Syndrome	6%
179	Myotonia Congenita	5.9%
180	Osteogenesis Imperfecta	5.9%
181	Jaw Diseases	5.8%
182	Zellweger Syndrome	5.8%
183	Osteochondritis	5.7%
184	Polymyalgia Rheumatica	5.7%
185	Metatarsalgia	5.7%
186	Cartilage Diseases	5.7%
187	Foot Diseases	5.7%
188	Rheumatism	5.7%
189	Chondromalacia	5.7%
190	Ectopia Cordis	5.7%
191	Single umbilical artery	5.7%
192	Polycystic Kidney, Autosomal Dominant	5.6%
193	Motor Neuron Disease	5.6%
194	Kallmann Syndrome	5.5%
195	Stiff-Person Syndrome	5.4%
196	Neoplastic Syndromes, Hereditary	5.4%
197	Congenital nystagmus	5.4%
198	Multiple System Atrophy	5.4%
199	Trauma, Nervous System	5.2%
200	Anemia, Neonatal	5.2%
201	Pelger-Huet Anomaly	5.2%
202	Persistent Fetal Circulation Syndrome	5.2%
203	Werner Syndrome	5.2%
204	Restless Legs Syndrome	5.2%
205	Umbilical hernia	5.2%
206	Toxoplasmosis, Congenital	5.1%
207	Ataxia Telangiectasia	5.1%
208	Familial Periodic Paralysis	5.1%
209	Nervous System Neoplasms	5.1%
210	Neurologic Manifestations	5.1%
211	Neurotoxicity Syndromes	5.1%
212	Klinefelter Syndrome	5.1%
213	Dystonia Musculorum Deformans	5.1%
214	Osteoarthritis, Spine	5.1%
215	Polyradiculoneuropathy	5%
216	Polyradiculoneuritis	5%
217	Myositis	5%
218	Isaacs syndrome	5%
219	Cortical Dysplasia	5%
220	Myotonic Disorders	5%
221	Malformations of Cortical Development	5%
222	Ischemic contracture	4.9%
223	Ocular Motility Disorders	4.9%
224	Cyclophoria	4.9%
225	Aortic coarctation	4.9%
226	Cor Triatriatum	4.9%
227	Coronary Vessel Anomalies	4.9%
228	Dental Enamel Hypoplasia	4.9%
229	Patent ductus arteriosus	4.9%
230	Ebstein Anomaly	4.9%
231	Heart Septal Defects	4.9%
232	Hypodontia	4.9%
233	Macrostomia	4.9%
234	Microstomia	4.9%
235	Tetralogy of Fallot	4.9%
236	Transposition of Great Vessels	4.9%
237	Hypoplastic Left Heart Syndrome	4.9%
238	May-Thurner Syndrome	4.9%
239	Temporomandibular Joint Disorders	4.9%
240	Wolff-Parkinson-White Syndrome	4.8%
241	Hepatolenticular Degeneration	4.8%
242	Subacute Combined Degeneration	4.8%
243	Rheumatic Fever	4.7%
244	Hyperkeratosis, Epidermolytic	4.7%
245	Welander Distal Myopathy	4.6%
246	Congenital Hypothyroidism	4.6%
247	Neonatal Abstinence Syndrome	4.6%
248	Ophthalmoplegic Migraine	4.6%
249	Canavan Disease	4.5%
250	Alexander Disease	4.5%
251	Fetal Growth Retardation	4.5%
252	Anemia, Sickle Cell	4.5%
253	Thalassemia	4.5%
254	Arthritis, Gouty	4.5%
255	Fetal Hypoxia	4.5%
256	Fetal Alcohol Spectrum Disorders	4.5%
257	Sleep Wake Disorders	4.5%
258	Syphilis, Congenital	4.4%
259	Temporomandibular Joint Dysfunction Syndrome	4.4%
260	Encephalomyelitis	4.4%
261	Prion Diseases	4.4%
262	Autonomic Dysreflexia	4.4%
263	Complex Regional Pain Syndromes	4.4%
264	Amyotrophic Lateral Sclerosis	4.4%
265	Hip Contracture	4.4%
266	Periarthritis	4.4%
267	Lafora Disease	4.3%
268	Unverricht-Lundborg Syndrome	4.3%
269	Albinism	4.3%
270	Medial Tibial Stress Syndrome	4.3%
271	Long QT Syndrome	4.3%
272	Tricuspid Atresia	4.3%
273	Arrhythmogenic Right Ventricular Dysplasia	4.3%
274	Gonadal Dysgenesis	4.3%
275	Adrenogenital Syndrome	4.3%
276	Ovotesticular Disorders of Sex Development	4.3%
277	Mitochondrial Myopathies	4.3%
278	Muscle Cramp	4.2%
279	Eosinophilia-Myalgia Syndrome	4.2%
280	Spinal Muscular Atrophy	4.2%
281	Progressive Muscular Atrophy	4.2%
282	Rheumatoid Arthritis	4.2%
283	Juvenile arthritis	4.2%
284	Huntington Disease	4.2%
285	Craniofacial Abnormalities	4.1%
286	Amyloid Neuropathies, Familial	4.1%
287	Meningoencephalitis	4.1%
288	Adrenoleukodystrophy	4.1%
289	Ankylosing spondylitis	4%
290	Hyperandrogenism	4%
291	Parkinson Disease	4%
292	Autoimmune Lymphoproliferative Syndrome	4%
293	Neuronal Ceroid-Lipofuscinoses	4%
294	Arthritis	4%
295	Bone Diseases, Developmental	4%
296	Bursitis	4%
297	Hyperostosis	4%
298	Joint Instability	4%
299	Myofascial Pain Syndromes	4%
300	Osteitis	4%
301	Osteitis Deformans	4%
302	Osteochondrosis	4%
303	Rhabdomyolysis	4%
304	Spinal Diseases	4%
305	Synovitis	4%
306	Joint laxity	4%
307	Polyarthritis	4%
308	Frozen shoulder	4%
309	Patellofemoral Pain Syndrome	4%
310	Congenital Hyperinsulinism	3.9%
311	Menkes Kinky Hair Syndrome	3.9%
312	Chorioamnionitis	3.9%
313	Rett Syndrome	3.9%
314	Spinal Cord Injuries	3.9%
315	Angioedemas, Hereditary	3.9%
316	Leukomalacia, Periventricular	3.9%
317	Marchiafava-Bignami Disease	3.8%
318	Peripheral Nerve Injuries	3.8%
319	Lewy Body Disease	3.8%
320	Guillain-Barre Syndrome	3.8%
321	Osteoarthritis, Knee	3.8%
322	Myasthenia Gravis	3.8%
323	Asterixis	3.8%
324	Ballismus	3.8%
325	Gigantism	3.7%
326	Spinal Neoplasms	3.7%
327	Spondylitis	3.7%
328	Muscle Weakness	3.7%
329	Muscle Rigidity	3.7%
330	Muscle Spasticity	3.7%
331	Cogwheel Rigidity	3.7%
332	Nuchal Rigidity	3.7%
333	Pneumocephalus	3.7%
334	Poliomyelitis	3.7%
335	Macrocephaly	3.6%
336	Lambert-Eaton Myasthenic Syndrome	3.6%
337	Mucopolysaccharidosis II	3.6%
338	Wiskott-Aldrich Syndrome	3.6%
339	Familial Mediterranean Fever	3.6%
340	Progressive supranuclear palsy	3.6%
341	Duane Retraction Syndrome	3.5%
342	Myelitis, Transverse	3.5%
343	Arthritis, Psoriatic	3.5%
344	Aortopulmonary Septal Defect	3.5%
345	Double Outlet Right Ventricle	3.5%
346	Endocardial Cushion Defects	3.5%
347	Myocardial bridging	3.5%
348	Aorticopulmonary Septal Defect	3.5%
349	Striatonigral Degeneration	3.4%
350	Leukoencephalitis, Acute Hemorrhagic	3.4%
351	Hypokalemic periodic paralysis	3.4%
352	Bone Diseases, Endocrine	3.4%
353	Sleep Disorders, Circadian Rhythm	3.4%
354	Bone Diseases, Infectious	3.3%
355	Bone neoplasms	3.3%
356	Compartment syndromes	3.3%
357	Maxillary Diseases	3.3%
358	Osteopenia	3.3%
359	Tendinitis	3.3%
360	Tendinopathy	3.3%
361	Miller Fisher Syndrome	3.3%
362	Dyskinesia, Drug-Induced	3.3%
363	Bone Resorption	3.3%
364	Hemarthrosis	3.3%
365	Tietze's Syndrome	3.3%
366	Aseptic Necrosis of Bone	3.3%
367	Brain Diseases	3.3%
368	Dysautonomia	3.3%
369	Meningitis	3.3%
370	Movement Disorders	3.3%
371	Pachymeningitis	3.3%
372	Spinal Cord Diseases	3.3%
373	Vagus Nerve Disorder	3.3%
374	Glossopharyngeal Neuralgia	3.3%
375	Abducens Nerve Diseases	3.3%
376	Heavy Metal Poisoning, Nervous System	3.3%
377	Neuromuscular Junction Diseases	3.3%
378	Tauopathies	3.3%
379	Trochlear Nerve Diseases	3.3%
380	Peripheral Nervous System Diseases	3.3%
381	Botulism	3.3%
382	Opsoclonus-Myoclonus Syndrome	3.3%
383	Neuroleptic Malignant Syndrome	3.3%
384	Myelinolysis, Central Pontine	3.3%
385	Myalgia	3.3%
386	Myelitis	3.3%
387	Progressive bulbar palsy	3.3%
388	Bulbar palsy	3.3%
389	Epidural Abscess	3.3%
390	Olfactory Nerve Injuries	3.3%
391	Neuromyelitis Optica	3.3%
392	Polymyositis	3.3%
393	Causalgia	3.2%
394	Rheumatoid Nodule	3.2%
395	Friedreich Ataxia	3.2%
396	MPTP Poisoning	3.2%
397	Arthritis, Reactive	3.1%
398	Optic Atrophy, Hereditary, Leber	3.1%
399	Ophthalmia Neonatorum	3.1%
400	Shy-Drager Syndrome	3.1%
401	Brain Diseases, Metabolic, Inborn	3.1%
402	Encephalomyelitis, Acute Disseminated	3%
403	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3%
404	Paralysis, Obstetric	3%
405	Retinopathy of Prematurity	3%
406	Romano-Ward Syndrome	3%
407	Amino Acid Metabolism, Inborn Errors	3%
408	Carbohydrate Metabolism, Inborn Errors	3%
409	Metal Metabolism, Inborn Errors	3%
410	Progeria	3%
411	Lysosomal Storage Diseases	3%
412	Cytochrome-c Oxidase Deficiency	3%
413	Peroxisomal Disorders	3%
414	Bronchopulmonary Dysplasia	3%
415	Spondylarthropathies	3%
416	Akathisia, Drug-Induced	3%
417	Facial Nerve Injuries	2.9%
418	Mitochondrial Encephalomyopathies	2.9%
419	Horner Syndrome	2.9%
420	Leukoencephalopathy, Progressive Multifocal	2.9%
421	Felty Syndrome	2.9%
422	Central Nervous System Infection	2.8%
423	Optic Neuropathy	2.8%
424	Orbital Myositis	2.8%
425	Sickle Cell Trait	2.8%
426	Fabry Disease	2.8%
427	Brain Injuries	2.8%
428	Brain Neoplasms	2.8%
429	Multiple Sclerosis	2.8%
430	Spinal Cord Neoplasms	2.8%
431	Pyomyositis	2.8%
432	Facial Nerve Diseases	2.8%
433	Craniocerebral Trauma	2.8%
434	Parasomnia	2.8%
435	Dyssomnias	2.8%
436	Discitis	2.8%
437	Vestibulocochlear Nerve Diseases	2.8%
438	Decerebrate State	2.8%
439	Hemiparesis	2.8%
440	Meningism	2.8%
441	Paresis	2.8%
442	Seizures	2.8%
443	Sensation Disorders	2.8%
444	Central Nervous System Neoplasms	2.8%
445	Complex partial seizures	2.8%
446	Monoparesis	2.8%
447	Neurogenic Inflammation	2.8%
448	Gait Disorders, Neurologic	2.8%
449	Neuromuscular Manifestations	2.8%
450	Truncus Arteriosus, Persistent	2.7%
451	Galactosemias	2.7%
452	Urea Cycle Disorders, Inborn	2.7%
453	Tyrosinemias	2.7%
454	Sweating, Gustatory	2.7%
455	Auriculotemporal Syndrome	2.7%
456	Pseudohypoparathyroidism	2.7%
457	MELAS Syndrome	2.7%
458	Reflex Sympathetic Dystrophy	2.7%
459	Subdural Effusion	2.7%
460	Parkinsonian Disorders	2.7%
461	Nocturnal Myoclonus Syndrome	2.7%
462	Respiratory Distress Syndrome, Newborn	2.6%
463	Ainhum	2.6%
464	Bunion	2.6%
465	Dysostoses	2.6%
466	Fibrodysplasia Ossificans Progressiva	2.6%
467	Myoglobinuria	2.6%
468	Myositis Ossificans	2.6%
469	Spinal Stenosis	2.6%
470	Spondylosis	2.6%
471	Tenosynovitis	2.6%
472	Intervertebral Disc Degeneration	2.6%
473	Sacroiliitis	2.6%
474	Myasthenia Gravis, Autoimmune, Experimental	2.6%
475	Cutis Laxa	2.6%
476	Retinitis Pigmentosa	2.6%
477	Pigmentary retinopathy	2.6%
478	Porokeratosis	2.6%
479	Keratoderma, Palmoplantar	2.6%
480	Vasculitis, Central Nervous System	2.6%
481	Chronic granulomatous disease	2.6%
482	Jet Lag Syndrome	2.6%
483	Rheumatoid Vasculitis	2.5%
484	Limbic Encephalitis	2.5%
485	Giant Cell Epulis	2.5%
486	Lupus Vasculitis, Central Nervous System	2.5%
487	Kernicterus	2.5%
488	Brain Abscess	2.5%
489	Musculoskeletal Pain	2.5%
490	Ophthalmoplegia	2.5%
491	External Ophthalmoplegia	2.5%
492	Arthralgia	2.5%
493	Polyarthralgia	2.5%
494	Acromegaly	2.4%
495	Arteriovenous fistula	2.4%
496	Pupil Disorders	2.4%
497	Neurobehavioral Manifestations	2.4%
498	Epilepsy, Post-Traumatic	2.4%
499	Tuberculosis, Spinal	2.4%
500	Paraneoplastic Encephalomyelitis	2.4%
501	Hydrops Fetalis	2.4%
502	Uveomeningoencephalitic Syndrome	2.4%
503	Scrapie	2.4%
504	Sturge-Weber Syndrome	2.4%
505	Vertigo	2.4%
506	Central Cord Syndrome	2.4%
507	Alcohol-Induced Disorders, Nervous System	2.4%
508	Presenile dementia	2.3%
509	Senile dementia	2.3%
510	Meningitis, Bacterial	2.3%
511	Meningitis, Fungal	2.3%
512	Glycogen storage disease type II	2.3%
513	Chorea	2.3%
514	Acrodynia	2.3%
515	Acute Chest Syndrome	2.3%
516	Sicca Syndrome	2.3%
517	Sjogren's Syndrome	2.3%
518	Porphyrias, Hepatic	2.3%
519	Peutz-Jeghers Syndrome	2.3%
520	Thrombasthenia	2.2%
521	Antithrombin III Deficiency	2.2%
522	Protein C Deficiency	2.2%
523	Afibrinogenemia	2.2%
524	Factor VII Deficiency	2.2%
525	Factor X Deficiency	2.2%
526	Factor XII Deficiency	2.2%
527	Hemophilia A	2.2%
528	Activated Protein C Resistance	2.2%
529	Factor II deficiency	2.2%
530	Factor VIII Deficiency	2.2%
531	Factor V deficiency	2.2%
532	Factor XI Deficiency	2.2%
533	Hypoprothrombinemias	2.2%
534	Fanconi Anemia	2.2%
535	Nesidioblastosis	2.2%
536	Anemia, Diamond-Blackfan	2.2%
537	Vocal Cord Paralysis	2.2%
538	Homocystinuria	2.2%
539	Denys-Drash Syndrome	2.2%
540	Arthritis, Infectious	2.2%
541	Leigh Disease	2.2%
542	Eosinophilic Granuloma	2.2%
543	Anterior Compartment Syndrome	2.2%
544	Osteomyelitis	2.2%
545	Osteoporosis	2.2%
546	Periostitis	2.2%
547	Enthesopathy	2.2%
548	Bone Demineralization, Pathologic	2.2%
549	Post-Traumatic Osteoporosis	2.2%
550	Arthritis, Experimental	2.2%
551	Abdominal Compartment Syndrome	2.2%
552	Alveolar Bone Loss	2.2%
553	Femur Head Necrosis	2.2%
554	Osteolysis	2.2%
555	Meige Syndrome	2.2%
556	Brachial Plexus Neuritis	2.2%
557	Neuralgic Amyotrophy	2.2%
558	Cerebral Ventriculitis	2.2%
559	Dementia, Vascular	2.1%
560	Brain Hemorrhage, Traumatic	2.1%
561	Palatal Neoplasms	2.1%
562	Voice Disorders	2.1%
563	Voice Disturbance	2.1%
564	Multiple Endocrine Neoplasia	2.1%
565	Hyperphosphaturia	2.1%
566	Amblyopia	2%
567	Paraneoplastic Cerebellar Degeneration	2%
568	Cerebrospinal Fluid Otorrhea	2%
569	Cerebrospinal Fluid Rhinorrhea	2%
570	Neuritis, Autoimmune, Experimental	2%
571	Gait Ataxia	2%
572	Dermatitis, Atopic	2%
573	Cerebellar Neoplasms	2%
574	Brain Death	2%
575	Coma, Post-Head Injury	2%
576	Akinetic Mutism	2%
577	Anoxic Encephalopathy	2%
578	Arachnoiditis	2%
579	Basal Ganglia Diseases	2%
580	Brain Damage, Chronic	2%
581	Cerebellar Diseases	2%
582	Encephalitis	2%
583	Encephalomalacia	2%
584	Epilepsy	2%
585	Hydrocephalus	2%
586	Congenital Hydrocephalus	2%
587	Hypothalamic Diseases	2%
588	Aseptic Meningitis	2%
589	Neuritis	2%
590	Polyneuritis	2%
591	Radiculitis	2%
592	Syringomyelia	2%
593	Thalamic Diseases	2%
594	Intracranial Hypertension	2%
595	Polyneuropathy	2%
596	Mononeuritis	2%
597	Aura	2%
598	Leukoencephalopathy	2%
599	Essential Tremor	2%
600	Neuroaxonal Dystrophies	2%
601	Familial Tremor	2%
602	Headache Disorders	2%
603	Mononeuropathies	2%
604	Intracranial Hypotension	2%
605	Alcohol Withdrawal Seizures	2%
606	Brachial Plexus Neuropathies	2%
607	Radiculopathy	2%
608	Mononeuropathy Multiplex	2%
609	Nerve Root Compression	2%
610	Brain Edema	2%
611	Brain Hypoxia	2%
612	Aqueductal Stenosis	2%
613	Pneumorrhachis	2%
614	Writer's Cramp	2%
615	Carotid Artery Injuries	1.9%
616	Chondrodysplasia Punctata	1.9%
617	Enchondromatosis	1.9%
618	Lordosis	1.9%
619	Osteosclerosis	1.9%
620	Spondylolysis	1.9%
621	kyphosis	1.9%
622	Kashin-Beck Disease	1.9%
623	Hip Dislocation	1.9%
624	Shoulder Dislocation	1.9%
625	Hip Dysplasia	1.9%
626	Alkaptonuria	1.9%
627	Glycogen Storage Disease	1.9%
628	Hypophosphatasia	1.9%
629	Propionic acidemia	1.9%
630	Dihydropyrimidine Dehydrogenase Deficiency	1.9%
631	Cystinosis	1.9%
632	Tarsal Tunnel Syndrome	1.9%
633	Cauda Equina Syndrome	1.9%
634	Posterior Leukoencephalopathy Syndrome	1.9%
635	Posterior reversible encephalopathy syndrome	1.9%
636	Dupuytren Contracture	1.9%
637	Dermatomyositis	1.9%
638	Joint Tuberculosis	1.9%
639	Tuberculosis, Osteoarticular	1.9%
640	Bone Tuberculosis	1.9%
641	Creutzfeldt-Jakob disease	1.9%
642	Basal Ganglia Cerebrovascular Disease	1.9%
643	Brain Injuries, Diffuse	1.8%
644	Traumatic Brain Injury	1.8%
645	Cerebellar Ataxia	1.8%
646	Supratentorial Neoplasms	1.8%
647	Torticollis	1.8%
648	Multiple Sclerosis, Chronic Progressive	1.8%
649	Multiple Sclerosis, Relapsing-Remitting	1.8%
650	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
651	Reflex, Abnormal	1.8%
652	Hyporeflexia	1.8%
653	Hyperreflexia	1.8%
654	Behcet Syndrome	1.8%
655	Akathisia	1.8%
656	Restlessness	1.8%
657	Psychomotor Agitation	1.8%
658	Tuberculosis, Meningeal	1.8%
659	Mucopolysaccharidosis III	1.8%
660	Gaucher Disease	1.7%
661	Kearns-Sayre syndrome	1.7%
662	Optic Nerve Glioma	1.7%
663	Alice in Wonderland Syndrome	1.7%
664	Brain Diseases, Metabolic	1.7%
665	Cerebrovascular Disorders	1.7%
666	Optic Atrophy	1.7%
667	Optic Neuritis	1.7%
668	Papilledema	1.7%
669	Strabismus	1.7%
670	Tolosa-Hunt Syndrome	1.7%
671	Cerebrovascular Insufficiency	1.7%
672	Arsenic Poisoning	1.7%
673	Dementia	1.7%
674	Central Nervous System Fungal Infections	1.7%
675	Conus Medullaris Syndrome	1.7%
676	Spinal Cord Vascular Diseases	1.7%
677	Diabetic Neuropathies	1.6%
678	Facial Injuries	1.6%
679	Facial Neuralgia	1.6%
680	Diabetic Amyotrophy	1.6%
681	Diabetic Autonomic Neuropathy	1.6%
682	Sleep Talking	1.6%
683	Manganese Poisoning	1.6%
684	Sleep Disorders, Intrinsic	1.6%
685	Orthostatic intolerance	1.6%
686	Hyaline Membrane Disease	1.6%
687	Rickets	1.6%
688	Anosmia	1.6%
689	Ataxia	1.6%
690	Athetosis	1.6%
691	Catalepsy	1.6%
692	Dystonia	1.6%
693	Hemiplegia	1.6%
694	Locked-In Syndrome	1.6%
695	Meningeal Neoplasms	1.6%
696	Muscle Hypertonia	1.6%
697	Muscle hypotonia	1.6%
698	Myoclonus	1.6%
699	Myotonia	1.6%
700	Neuralgia	1.6%
701	Paraplegia	1.6%
702	Pseudobulbar Palsy	1.6%
703	Quadriplegia	1.6%
704	Spasm	1.6%
705	Spastic Paraplegia	1.6%
706	Status Epilepticus	1.6%
707	Taste Disorders	1.6%
708	Tremor	1.6%
709	Monoplegia	1.6%
710	Hypokinesia	1.6%
711	Paraparesis	1.6%
712	Bradykinesia	1.6%
713	Waxy flexibility	1.6%
714	Action Tremor	1.6%
715	Resting Tremor	1.6%
716	Dysosmia	1.6%
717	Quadriparesis	1.6%
718	Mercury Poisoning, Nervous System	1.6%
719	Olfaction Disorders	1.6%
720	Myokymia	1.6%
721	Lead Poisoning, Nervous System	1.6%
722	Vestibular Neuronitis	1.6%
723	Somatosensory Disorders	1.6%
724	Neuropathic pain	1.6%
725	Hyperkinesia	1.6%
726	Intention tremor	1.6%
727	Vertebral Artery Dissection	1.6%
728	Carpal Tunnel Syndrome	1.6%
729	Vascular Headaches	1.6%
730	Amnesia, Transient Global	1.6%
731	Toxoplasmosis, Cerebral	1.6%
732	Osteoporosis, Postmenopausal	1.6%
733	Hypolipoproteinemias	1.6%
734	Papillon-Lefevre Disease	1.6%
735	Gait Apraxia	1.6%
736	Brain Concussion	1.6%
737	Hyperlipidemia, Familial Combined	1.6%
738	Melorheostosis	1.6%
739	neurofibroma	1.6%
740	Osteopetrosis	1.6%
741	Shoulder Pain	1.6%
742	Spondylolisthesis	1.6%
743	Hypoxia-Ischemia, Brain	1.6%
744	Hyperlipoproteinemia Type III	1.6%
745	Sciatica	1.6%
746	Tardive Dyskinesia	1.6%
747	Myoclonic Epilepsy	1.6%
748	Epilepsy, Temporal Lobe	1.6%
749	Epilepsy, Rolandic	1.6%
750	Benign Rolandic Epilepsy	1.6%
751	Persistent Vegetative State	1.6%
752	Acoustic Neuroma	1.5%
753	Pituitary Adenoma	1.5%
754	Pituitary Neoplasms	1.5%
755	Nephroblastoma	1.5%
756	Familial Hypophosphatemic Rickets	1.5%
757	Hand-Arm Vibration Syndrome	1.5%
758	Vision Disorders	1.4%
759	Metamorphopsia	1.4%
760	Visual Impairment	1.4%
761	Tay-Sachs Disease	1.4%
762	Optic Neuropathy, Ischemic	1.4%
763	Anterior Ischemic Optic Neuropathy	1.4%
764	Central Nervous System Bacterial Infections	1.4%
765	Niemann-Pick Disease, Type C	1.4%
766	Lactose Intolerance	1.4%
767	Variegate Porphyria	1.4%
768	Acute intermittent porphyria	1.4%
769	Porphyria Cutanea Tarda	1.4%
770	Facial Hemiatrophy	1.4%
771	Melkersson-Rosenthal Syndrome	1.4%
772	Meningitis, Cryptococcal	1.4%
773	Hyperhomocysteinemia	1.4%
774	Anisocoria	1.4%
775	Confusion	1.4%
776	Facial paralysis	1.4%
777	Lethargy	1.4%
778	Memory Disorders	1.4%
779	Perceptual Disorders	1.4%
780	Psychomotor Disorders	1.4%
781	Tonic Pupil	1.4%
782	Anhedonia	1.4%
783	Disorientation	1.4%
784	Facial Paresis	1.4%
785	Memory Loss	1.4%
786	Hemisensory Neglect	1.4%
787	Dysacusis	1.4%
788	Renal Aminoacidurias	1.4%
789	Fanconi Syndrome	1.4%
790	Meningitis, Listeria	1.4%
791	Pseudohypoaldosteronism	1.4%
792	Liddle Syndrome	1.4%
793	Meningitis, Haemophilus	1.4%
794	Meningitis, Pneumococcal	1.4%
795	Frontotemporal dementia	1.4%
796	Hyperlipoproteinemia Type IV	1.4%
797	Hyperlipoproteinemia Type V	1.4%
798	Sleep Bruxism	1.4%
799	Muscular Atrophy	1.4%
800	Respiratory Paralysis	1.4%
801	Tetany	1.4%
802	Mastoiditis	1.4%
803	Petrositis	1.4%
804	Cubital Tunnel Syndrome	1.4%
805	Diffuse Axonal Injury	1.4%
806	Brain Stem Neoplasms	1.4%
807	Adenomatous Polyposis Coli	1.4%
808	Basal Ganglia Hemorrhage	1.4%
809	Glycogen Storage Disease Type I	1.3%
810	Glycogen Storage Disease Type V	1.3%
811	Juvenile Myoclonic Epilepsy	1.3%
812	Myoclonic Epilepsies, Progressive	1.3%
813	Giant Cell Arteritis	1.3%
814	Temporal Arteritis	1.3%
815	Subarachnoid Hemorrhage, Traumatic	1.3%
816	Carotid Artery, Internal, Dissection	1.3%
817	Auditory Perceptual Disorders	1.3%
818	Cerebral Palsy	1.3%
819	Epilepsies, Partial	1.3%
820	Epilepsy, Generalized	1.3%
821	Pseudotumor Cerebri	1.3%
822	Sciatic Neuropathy	1.3%
823	Hypertensive Encephalopathy	1.3%
824	Ulnar Neuropathies	1.3%
825	Lesion of Sciatic Nerve	1.3%
826	Simple Partial Seizures	1.3%
827	Epilepsy, Reflex	1.3%
828	Ulnar Neuritis	1.3%
829	Radial nerve compression	1.3%
830	Radial Tunnel Syndrome	1.3%
831	Peroneal Neuropathies	1.3%
832	Radial Neuropathy	1.3%
833	Median Neuropathy	1.3%
834	Sciatic Nerve Palsy	1.3%
835	Femoral Neuropathy	1.3%
836	Tibial Neuropathy	1.3%
837	Ulnar Nerve Palsy	1.3%
838	Postural Orthostatic Tachycardia Syndrome	1.3%
839	Radial nerve palsy	1.3%
840	Headache Disorders, Primary	1.3%
841	Headache Disorders, Secondary	1.3%
842	Medication overuse headache	1.3%
843	Multiple Endocrine Neoplasia Type 1	1.3%
844	Subacute Sclerosing Panencephalitis	1.3%
845	Renal tubular acidosis	1.3%
846	Consciousness Disorders	1.2%
847	Mental Retardation	1.2%
848	Depressed Level of Consciousness	1.2%
849	Mental deficiency	1.2%
850	Intellectual Disability	1.2%
851	Bell Palsy	1.2%
852	Catatonia	1.2%
853	Herpes Zoster Oticus	1.2%
854	Aphonia	1.2%
855	Sleep Deprivation	1.2%
856	Dysphonia	1.2%
857	Pituitary Apoplexy	1.2%
858	Brain Contusion	1.2%
859	Osteomalacia	1.2%
860	Brain Infarction	1.2%
861	Putaminal Hemorrhage	1.2%
862	Hypoalphalipoproteinemias	1.1%
863	Choroid Plexus Papilloma	1.1%
864	Pituitary Diseases	1.1%
865	Infarction, Middle Cerebral Artery	1.1%
866	Infarction, Anterior Cerebral Artery	1.1%
867	Infarction, Posterior Cerebral Artery	1.1%
868	Thoracic Outlet Syndrome	1.1%
869	Carotid Artery Diseases	1.1%
870	Brain Ischemia	1.1%
871	Esotropia	1.1%
872	Exotropia	1.1%
873	Hypotension, Orthostatic	1.1%
874	Sleep Apnea Syndromes	1.1%
875	Cerebrovascular accident	1.1%
876	Kluver-Bucy Syndrome	1.1%
877	Vasospasm, Intracranial	1.1%
878	Spinal Cord Ischemia	1.1%
879	Intracranial Arterial Diseases	1.1%
880	Post-Exercise Hypotension	1.1%
881	Disorders of Excessive Somnolence	1.1%
882	Sleep Initiation and Maintenance Disorders	1.1%
883	Night Terrors	1.1%
884	Somnambulism	1.1%
885	Trigeminal Nerve Disorder	1.1%
886	Transient Insomnia	1.1%
887	Sleep Paralysis	1.1%
888	Chronic Insomnia	1.1%
889	REM Sleep Behavior Disorder	1.1%
890	Hypersomnia	1.1%
891	Dysgeusia	1.1%
892	Formication	1.1%
893	Hyperalgesia	1.1%
894	Hyperesthesia	1.1%
895	Hypesthesia	1.1%
896	Language Disorders	1.1%
897	Numbness	1.1%
898	Paresthesia	1.1%
899	Paraparesis, Spastic	1.1%
900	Trismus	1.1%
901	Epilepsia Partialis Continua	1.1%
902	Hypogeusia	1.1%
903	Meningeal Carcinomatosis	1.1%
904	Brown-Sequard Syndrome	1.1%
905	Lockjaw	1.1%
906	Allodynia	1.1%
907	Lead Poisoning, Nervous System, Childhood	1.1%
908	Lead Poisoning, Nervous System, Adult	1.1%
909	Ageusia	1.1%
910	Tuberculosis, Central Nervous System	1.1%
911	Alexia	1.1%
912	Dyslexia	1.1%
913	Hematoma, Subdural	1%
914	Hematoma, Epidural, Cranial	1%
915	Glycosuria, Renal	1%
916	Cystinuria	1%
917	Cerebral Infarction	1%
918	Brain Stem Infarctions	1%
919	Hoarseness	1%
920	Moyamoya Disease	1%
921	Alcohol Withdrawal Delirium	1%
922	West Nile Fever	1%
923	Neurofibrosarcoma	1%
924	Polyradiculopathy	1%
925	Post-Traumatic Headache	1%
926	Tension Headache	1%
927	Epilepsy, Complex Partial	1%
928	Migraine Disorders	1%
929	Abdominal Migraine	1%
930	Status Migrainosus	1%
931	Cervicogenic Headache	1%
932	Eye Injuries	1%
933	Diplopia	0.9%
934	Scotoma	0.9%
935	Photophobia	0.9%
936	Hemifacial Spasm	0.9%
937	Amaurosis	0.9%
938	Blindness	0.9%
939	Reye Syndrome	0.9%
940	Neuroaspergillosis	0.9%
941	Intracranial Embolism and Thrombosis	0.9%
942	Hepatic Encephalopathy	0.9%
943	Agnosia	0.9%
944	Apraxias	0.9%
945	Hallucinations	0.9%
946	Hemianopsia	0.9%
947	Hyperacusis	0.9%
948	Tinnitus	0.9%
949	Visual Agnosia	0.9%
950	Anosognosia	0.9%
951	Wernicke-Korsakoff Syndrome	0.9%
952	Phonophobia	0.9%
953	Hearing Loss	0.9%
954	Sarcopenia	0.9%
955	Nose Neoplasms	0.9%
956	Lateral Medullary Syndrome	0.9%
957	Radicular Cyst	0.9%
958	Renal Osteodystrophy	0.9%
959	Renal rickets	0.9%
960	Pseudorabies	0.8%
961	Hematoma, Subdural, Intracranial	0.8%
962	Hematoma, Subdural, Chronic	0.8%
963	Hematoma, Subdural, Acute	0.8%
964	Amnesia	0.8%
965	Delirium	0.8%
966	Empty Sella Syndrome	0.8%
967	Hyperpituitarism	0.8%
968	Hypopituitarism	0.8%
969	Dissociative Amnesia	0.8%
970	Color blindness	0.8%
971	Global Amnesia	0.8%
972	Hypophysitis	0.8%
973	Meningioma	0.8%
974	Neurosyphilis	0.8%
975	Cerebral Arterial Diseases	0.8%
976	Vertebrobasilar Insufficiency	0.8%
977	Anterior Spinal Artery Syndrome	0.8%
978	Basilar Artery Stenosis	0.8%
979	Vertebral Artery Stenosis	0.8%
980	Sleep Apnea, Obstructive	0.8%
981	Sleep Apnea, Central	0.8%
982	Intracranial Hemorrhage, Hypertensive	0.8%
983	Transient Cerebral Ischemia	0.8%
984	Cluster Headache	0.8%
985	Migraine with Aura	0.8%
986	Familial Hemiplegic Migraine	0.8%
987	Chronic Paroxysmal Hemicrania	0.8%
988	SUNCT Syndrome	0.8%
989	Paroxysmal Hemicrania	0.8%
990	Narcolepsy	0.8%
991	Trigeminal Neuralgia	0.8%
992	Kleine-Levin Syndrome	0.8%
993	Agraphia	0.8%
994	Anomia	0.8%
995	Cluttering	0.8%
996	Language Development Disorders	0.8%
997	Speech Disorders	0.8%
998	Syncope	0.8%
999	Stupor	0.8%
1000	Dysgraphia	0.8%
1001	Presyncope	0.8%
1002	Dyslalia	0.8%
1003	Wernicke Encephalopathy	0.7%
1004	AIDS Dementia Complex	0.7%
1005	Phantom pain	0.7%
1006	Phantom Limb Pain	0.7%
1007	Lyme Neuroborreliosis	0.7%
1008	Eye Burns	0.7%
1009	Malaria, Cerebral	0.7%
1010	Carotid Stenosis	0.7%
1011	Intracranial Aneurysm	0.7%
1012	Neurocysticercosis	0.7%
1013	Amaurosis Fugax	0.7%
1014	Blindness, Cortical	0.7%
1015	Dyscalculia	0.7%
1016	Intracranial Arteriosclerosis	0.7%
1017	Cerebral Atherosclerosis	0.7%
1018	Subarachnoid Hemorrhage	0.7%
1019	Cerebral Arteriosclerosis	0.7%
1020	Cerebral Hemorrhage	0.7%
1021	Cerebral Thrombosis	0.7%
1022	Intracranial Embolism	0.7%
1023	Intracranial Thrombosis	0.7%
1024	Deafness	0.7%
1025	Hearing Loss, Sudden	0.7%
1026	Gerstmann Syndrome	0.7%
1027	Hearing Loss, Bilateral	0.7%
1028	Hearing Loss, High-Frequency	0.7%
1029	Hearing Loss, Mixed Conductive-Sensorineural	0.7%
1030	Prosopagnosia	0.7%
1031	Apraxia, Ideomotor	0.7%
1032	Charles Bonnet Syndrome	0.7%
1033	Hearing Loss, Unilateral	0.7%
1034	Complete Hearing Loss	0.7%
1035	Alien Hand Syndrome	0.7%
1036	Deaf Mutism	0.7%
1037	Waterhouse-Friderichsen Syndrome	0.7%
1038	Hyperprolactinemia	0.7%
1039	Subclavian Steal Syndrome	0.7%
1040	Pick Disease of the Brain	0.7%
1041	Cataplexy	0.7%
1042	Aphasia	0.7%
1043	Articulation Disorders	0.7%
1044	Echolalia	0.7%
1045	Stuttering	0.7%
1046	Dysphasia	0.7%
1047	Corneal Scar	0.6%
1048	Retrograde amnesia	0.6%
1049	Amnesia, Anterograde	0.6%
1050	Carotid Artery Thrombosis	0.6%
1051	Dysarthria	0.6%
1052	Mutism	0.6%
1053	Selective Mutism	0.6%
1054	Cerebral Amyloid Angiopathy	0.6%
1055	Sinus Thrombosis, Intracranial	0.6%
1056	Alexia, Pure	0.5%
1057	Cavernous Sinus Thrombosis	0.5%
1058	Sagittal Sinus Thrombosis	0.5%
1059	Corneal Perforation	0.5%
1060	Nelson Syndrome	0.5%
1061	Prolactinoma	0.5%
1062	Growth Hormone-Secreting Pituitary Adenoma	0.5%

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