MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Schizencephaly

(UMLS:C0266484)

Definition:: Cortical malformations characterized by grey matter-lined cleft or cyst that extends from the EPENDYMA often to the PIA MATER outer surface. The grey matter that lines the cleft is often POLYMICROGYRIA. It is associated with developmental delay, motor disturbance and seizures.
UMLS ID:: C0266484
MeSH ID:: D065707

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.507.500.750

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.507.500.750

Synonym(s)

Schizencephaly

SCHIZENCEPHALY

Schizencephalic porencephaly

schizencephaly

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Fingolimod Hydrochloride	FAERS: 2	US FAERS
2	Copper	FAERS: 1	US FAERS
3	Ondansetron	FAERS: 1	US FAERS
4	Paroxetine	FAERS: 1	US FAERS
5	sapropterin	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Polymicrogyria	48.8%
2	Porencephaly	34.1%
3	Hydranencephaly	27%
4	Neural Tube Defects	27%
5	Tethered Cord Syndrome	27%
6	Iniencephaly	27%
7	Craniorachischisis	27%
8	Exencephaly	27%
9	Septo-Optic Dysplasia	27%
10	Classical Lissencephalies and Subcortical Band Heterotopias	23.8%
11	Lissencephaly	23.2%
12	Pachygyria	23.2%
13	Periventricular Nodular Heterotopia	23.2%
14	Dural Arteriovenous Fistula	20.4%
15	Dandy-Walker Syndrome	20%
16	Central Nervous System Cysts	19.6%
17	Microcephaly	18%
18	Macrocephaly	18%
19	Anencephaly	17.6%
20	Aicardi's syndrome	15.9%
21	Meningomyelocele	15.8%
22	Spina Bifida	15.8%
23	Holoprosencephaly	15.1%
24	Abnormalities, Drug-Induced	14.9%
25	Situs Inversus	14.9%
26	Tuberous Sclerosis	12.8%
27	Meningocele	12.7%
28	Encephalocele	12.7%
29	Smith-Magenis syndrome	12.5%
30	Eye Abnormalities	11.8%
31	Cardiovascular Abnormalities	11.8%
32	Beckwith-Wiedemann Syndrome	11.5%
33	Wolf-Hirschhorn Syndrome	11.5%
34	Skin Abnormalities	11.4%
35	Lymphatic Abnormalities	11.4%
36	Congenital Microtia	11.4%
37	Charcot-Marie-Tooth Disease	11.3%
38	Congenital diaphragmatic hernia	11.1%
39	Cri-du-Chat Syndrome	10.6%
40	Down Syndrome	10.6%
41	Trisomy 21	10.6%
42	Cranial nerve diseases	10.4%
43	Demyelinating Diseases	10.4%
44	Demyelination	10.4%
45	Neuromuscular Diseases	10.4%
46	Chronobiology Disorders	10.4%
47	Dermal Sinus	10.4%
48	Spina Bifida Cystica	10.4%
49	Spina Bifida Occulta	10.4%
50	Genetic Diseases, Inborn	9.8%
51	Alstrom Syndrome	9.7%
52	Urogenital Abnormalities	9.5%
53	Prader-Willi Syndrome	9.1%
54	Rubinstein-Taybi Syndrome	8.7%
55	Motor Neuron Disease	8.4%
56	Mobius Syndrome	8.3%
57	Ectodermal Dysplasia	8.2%
58	Aplasia Cutis Congenita	8.2%
59	Trauma, Nervous System	8.1%
60	Prune Belly Syndrome	8.1%
61	Twins, Conjoined	8.1%
62	Waardenburg Syndrome	8.1%
63	CHARGE Syndrome	8%
64	Nervous System Neoplasms	7.9%
65	Neurologic Manifestations	7.9%
66	Neurotoxicity Syndromes	7.9%
67	Fetal Diseases	7.4%
68	Stiff-Person Syndrome	7.3%
69	Refsum Disease	7.2%
70	Multiple System Atrophy	7.2%
71	Ocular Motility Disorders	7%
72	Cyclophoria	7%
73	Nail-Patella Syndrome	6.7%
74	Restless Legs Syndrome	6.7%
75	Polyradiculoneuropathy	6.7%
76	Polyradiculoneuritis	6.7%
77	Xeroderma	6.6%
78	Encephalomyelitis	6.6%
79	Prion Diseases	6.6%
80	Autonomic Dysreflexia	6.6%
81	Complex Regional Pain Syndromes	6.6%
82	Maxillofacial Abnormalities	6.6%
83	Dextrocardia	6.5%
84	Williams Syndrome	6.5%
85	Sleep Wake Disorders	6.4%
86	Cockayne Syndrome	6.4%
87	Abnormalities, Radiation-Induced	6.3%
88	Anophthalmos	6.2%
89	Anus, Imperforate	6.2%
90	Microphthalmos	6.2%
91	Limb Deformities, Congenital	6.2%
92	Craniofacial Abnormalities	6.2%
93	Myasthenic Syndromes, Congenital	6.2%
94	Anorectal Malformations	6.2%
95	Subacute Combined Degeneration	6.2%
96	Bloom Syndrome	6.1%
97	Marfan Syndrome	6.1%
98	Spinal Muscular Atrophy	5.9%
99	Progressive Muscular Atrophy	5.9%
100	Marchiafava-Bignami Disease	5.8%
101	Kartagener Syndrome	5.7%
102	Amyotrophic Lateral Sclerosis	5.6%
103	Ophthalmoplegic Migraine	5.6%
104	Parkinson Disease	5.6%
105	Spinal Cord Injuries	5.5%
106	Brain Diseases	5.5%
107	Dysautonomia	5.5%
108	Meningitis	5.5%
109	Movement Disorders	5.5%
110	Pachymeningitis	5.5%
111	Spinal Cord Diseases	5.5%
112	Vagus Nerve Disorder	5.5%
113	Glossopharyngeal Neuralgia	5.5%
114	Abducens Nerve Diseases	5.5%
115	Heavy Metal Poisoning, Nervous System	5.5%
116	Neuromuscular Junction Diseases	5.5%
117	Tauopathies	5.5%
118	Trochlear Nerve Diseases	5.5%
119	Peripheral Nervous System Diseases	5.5%
120	Meningoencephalitis	5.4%
121	Polycystic Kidney Diseases	5.4%
122	Peripheral Nerve Injuries	5.4%
123	Myasthenia Gravis	5.3%
124	Asterixis	5.3%
125	Ballismus	5.3%
126	Cystic Fibrosis	5.2%
127	Dystonia Musculorum Deformans	5.1%
128	POEMS Syndrome	5.1%
129	Scimitar Syndrome	5.1%
130	Blepharophimosis	5.1%
131	Laryngostenosis	5.1%
132	Mouth Abnormalities	5.1%
133	Esophageal Atresia	5%
134	Intestinal Atresia	5%
135	Horseshoe Kidney	5%
136	Pectus excavatum	5%
137	Abdominal Cramps	5%
138	Amniotic Band Syndrome	5%
139	Asphyxia Neonatorum	5%
140	Infant, Premature, Diseases	5%
141	Infantile Colic	5%
142	Klippel-Feil Syndrome	5%
143	Gastroschisis	5%
144	Synostosis	5%
145	Acrodermatitis	4.9%
146	Lymphangiectasis, Intestinal	4.9%
147	Gianotti-Crosti Syndrome	4.9%
148	Lewy Body Disease	4.9%
149	Pneumocephalus	4.9%
150	Poliomyelitis	4.9%
151	Myelitis	4.9%
152	Progressive bulbar palsy	4.9%
153	Bulbar palsy	4.9%
154	Guillain-Barre Syndrome	4.9%
155	Retinal Dysplasia	4.8%
156	Fragile X Syndrome	4.8%
157	Aniridia	4.8%
158	Epidermolysis Bullosa	4.7%
159	Chronic Fatigue Syndrome	4.6%
160	Neuroleptic Malignant Syndrome	4.6%
161	Myelinolysis, Central Pontine	4.6%
162	Sleep Disorders, Circadian Rhythm	4.6%
163	Striatonigral Degeneration	4.6%
164	Lambert-Eaton Myasthenic Syndrome	4.6%
165	Causalgia	4.5%
166	Ataxia Telangiectasia	4.4%
167	Botulism	4.4%
168	Central Nervous System Infection	4.4%
169	Myopathy	4.4%
170	Optic Neuropathy	4.4%
171	Meconium Aspiration Syndrome	4.4%
172	Epidural Abscess	4.3%
173	Olfactory Nerve Injuries	4.3%
174	Progressive supranuclear palsy	4.3%
175	Muscular Dystrophy	4.3%
176	Congenital nystagmus	4.3%
177	Arthrogryposis	4.2%
178	Choanal Atresia	4.2%
179	Tracheobronchomegaly	4.2%
180	Laryngocele	4.2%
181	Smith-Lemli-Opitz Syndrome	4.2%
182	Myelitis, Transverse	4.2%
183	Facial Nerve Diseases	4.2%
184	Craniocerebral Trauma	4.2%
185	Parasomnia	4.2%
186	Dyssomnias	4.2%
187	MPTP Poisoning	4.2%
188	Choledochal Cyst	4.2%
189	Hermaphroditism	4.2%
190	Disorders of Sex Development	4.2%
191	Craniosynostosis	4.2%
192	Myotonic Dystrophy	4.2%
193	Syndactyly	4.2%
194	Brachycephaly	4.2%
195	Lafora Disease	4.2%
196	Unverricht-Lundborg Syndrome	4.2%
197	Dyskinesia, Drug-Induced	4.2%
198	Cryptorchidism	4.2%
199	Hypospadias	4.2%
200	Vestibulocochlear Nerve Diseases	4.1%
201	Decerebrate State	4.1%
202	Hemiparesis	4.1%
203	Meningism	4.1%
204	Paresis	4.1%
205	Seizures	4.1%
206	Sensation Disorders	4.1%
207	Central Nervous System Neoplasms	4.1%
208	Complex partial seizures	4.1%
209	Monoparesis	4.1%
210	Neurogenic Inflammation	4.1%
211	Gait Disorders, Neurologic	4.1%
212	Neuromuscular Manifestations	4.1%
213	Sweating, Gustatory	4.1%
214	Auriculotemporal Syndrome	4.1%
215	Leukoencephalitis, Acute Hemorrhagic	4.1%
216	Myotonia Congenita	4.1%
217	Primary Ciliary Dyskinesia	4.1%
218	Encephalomyelitis, Acute Disseminated	4.1%
219	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
220	Reflex Sympathetic Dystrophy	4%
221	Subdural Effusion	4%
222	Parkinsonian Disorders	4%
223	Nocturnal Myoclonus Syndrome	4%
224	Opsoclonus-Myoclonus Syndrome	4%
225	Ichthyosis, X-Linked	4%
226	Huntington Disease	4%
227	Miller Fisher Syndrome	4%
228	Canavan Disease	3.9%
229	Alexander Disease	3.9%
230	Shy-Drager Syndrome	3.9%
231	Brain Injuries	3.9%
232	Neoplastic Syndromes, Hereditary	3.9%
233	Toxoplasmosis, Congenital	3.9%
234	Brain Neoplasms	3.9%
235	Multiple Sclerosis	3.9%
236	Spinal Cord Neoplasms	3.9%
237	Neuromyelitis Optica	3.9%
238	Horner Syndrome	3.8%
239	Akathisia, Drug-Induced	3.8%
240	Hepatolenticular Degeneration	3.8%
241	Anemia, Neonatal	3.7%
242	Multiple Epiphyseal Dysplasia	3.7%
243	Osteochondrodysplasias	3.7%
244	Pelger-Huet Anomaly	3.7%
245	Persistent Fetal Circulation Syndrome	3.7%
246	Werner Syndrome	3.7%
247	Facial Nerve Injuries	3.7%
248	Noonan Syndrome	3.7%
249	Umbilical hernia	3.7%
250	Pseudoxanthoma Elasticum	3.7%
251	Amelia	3.6%
252	Arachnodactyly	3.6%
253	Ectopia Cordis	3.6%
254	Ectromelia	3.6%
255	Hemimelia	3.6%
256	Phocomelia	3.6%
257	Sirenomelia	3.6%
258	Polydactyly	3.6%
259	Brachydactyly	3.6%
260	Plagiocephaly	3.6%
261	Lower Extremity Deformities, Congenital	3.6%
262	Upper Extremity Deformities, Congenital	3.6%
263	Single umbilical artery	3.6%
264	Laryngomalacia	3.6%
265	Pectus carinatum	3.6%
266	Bladder Exstrophy	3.5%
267	Epispadias	3.5%
268	Leukomalacia, Periventricular	3.5%
269	Multicystic Dysplastic Kidney	3.5%
270	Muscular Dystrophy, Duchenne	3.5%
271	Pupil Disorders	3.5%
272	Neurobehavioral Manifestations	3.5%
273	Leukoencephalopathy, Progressive Multifocal	3.4%
274	Paraneoplastic Encephalomyelitis	3.4%
275	Xeroderma Pigmentosum	3.3%
276	Uveomeningoencephalitic Syndrome	3.3%
277	Vasculitis, Central Nervous System	3.3%
278	Brain Abscess	3.3%
279	Ophthalmoplegia	3.3%
280	External Ophthalmoplegia	3.3%
281	Scrapie	3.3%
282	Sturge-Weber Syndrome	3.3%
283	Vertigo	3.3%
284	Central Cord Syndrome	3.3%
285	Alcohol-Induced Disorders, Nervous System	3.3%
286	Jet Lag Syndrome	3.3%
287	Zellweger Syndrome	3.3%
288	Presenile dementia	3.3%
289	Senile dementia	3.3%
290	Meningitis, Bacterial	3.3%
291	Meningitis, Fungal	3.3%
292	Limbic Encephalitis	3.2%
293	Myasthenia Gravis, Autoimmune, Experimental	3.2%
294	Akinetic Mutism	3.2%
295	Anoxic Encephalopathy	3.2%
296	Arachnoiditis	3.2%
297	Basal Ganglia Diseases	3.2%
298	Brain Damage, Chronic	3.2%
299	Cerebellar Diseases	3.2%
300	Encephalitis	3.2%
301	Encephalomalacia	3.2%
302	Epilepsy	3.2%
303	Hydrocephalus	3.2%
304	Congenital Hydrocephalus	3.2%
305	Hypothalamic Diseases	3.2%
306	Aseptic Meningitis	3.2%
307	Neuritis	3.2%
308	Polyneuritis	3.2%
309	Radiculitis	3.2%
310	Syringomyelia	3.2%
311	Thalamic Diseases	3.2%
312	Intracranial Hypertension	3.2%
313	Polyneuropathy	3.2%
314	Mononeuritis	3.2%
315	Aura	3.2%
316	Leukoencephalopathy	3.2%
317	Essential Tremor	3.2%
318	Neuroaxonal Dystrophies	3.2%
319	Familial Tremor	3.2%
320	Headache Disorders	3.2%
321	Mononeuropathies	3.2%
322	Intracranial Hypotension	3.2%
323	Brachial Plexus Neuropathies	3.2%
324	Radiculopathy	3.2%
325	Mononeuropathy Multiplex	3.2%
326	Nerve Root Compression	3.2%
327	Brain Edema	3.2%
328	Brain Hypoxia	3.2%
329	Aqueductal Stenosis	3.2%
330	Pneumorrhachis	3.2%
331	Writer's Cramp	3.2%
332	Chorea	3.2%
333	Amyloid Neuropathies, Familial	3.2%
334	Acrodynia	3.2%
335	Friedreich Ataxia	3.2%
336	Epilepsy, Post-Traumatic	3.2%
337	Meige Syndrome	3.2%
338	Brachial Plexus Neuritis	3.2%
339	Neuralgic Amyotrophy	3.2%
340	Cerebral Ventriculitis	3.2%
341	Polycystic Kidney, Autosomal Dominant	3.2%
342	Acrocephalosyndactylia	3.2%
343	Dwarfism	3.1%
344	Turner Syndrome	3.1%
345	Jaw Abnormalities	3.1%
346	Sjogren-Larsson Syndrome	3.1%
347	Duane Retraction Syndrome	3.1%
348	Neonatal Abstinence Syndrome	3.1%
349	Kallmann Syndrome	3.1%
350	Neuronal Ceroid-Lipofuscinoses	3%
351	Fetal Growth Retardation	3%
352	Osteogenesis Imperfecta	3%
353	Fetal Hypoxia	3%
354	Fetal Alcohol Spectrum Disorders	3%
355	Basal Cell Nevus Syndrome	3%
356	Aortic coarctation	2.9%
357	Cor Triatriatum	2.9%
358	Coronary Vessel Anomalies	2.9%
359	Dental Enamel Hypoplasia	2.9%
360	Patent ductus arteriosus	2.9%
361	Ebstein Anomaly	2.9%
362	Heart Septal Defects	2.9%
363	Hypodontia	2.9%
364	Macrostomia	2.9%
365	Microstomia	2.9%
366	Syphilis, Congenital	2.9%
367	Tetralogy of Fallot	2.9%
368	Transposition of Great Vessels	2.9%
369	Hypoplastic Left Heart Syndrome	2.9%
370	May-Thurner Syndrome	2.9%
371	Craniofacial Dysostosis	2.9%
372	Wolff-Parkinson-White Syndrome	2.9%
373	Rett Syndrome	2.9%
374	Cleft Palate	2.9%
375	Vocal Cord Paralysis	2.9%
376	Lupus Vasculitis, Central Nervous System	2.9%
377	Voice Disorders	2.8%
378	Voice Disturbance	2.8%
379	Adrenoleukodystrophy	2.8%
380	Tarsal Tunnel Syndrome	2.8%
381	Cauda Equina Syndrome	2.8%
382	Posterior Leukoencephalopathy Syndrome	2.8%
383	Posterior reversible encephalopathy syndrome	2.8%
384	Antley-Bixler Syndrome Phenotype	2.8%
385	Brain Death	2.8%
386	Coma, Post-Head Injury	2.8%
387	Poland Syndrome	2.7%
388	Amblyopia	2.7%
389	Anemia, Sickle Cell	2.7%
390	Thalassemia	2.7%
391	Paraneoplastic Cerebellar Degeneration	2.7%
392	Familial Mediterranean Fever	2.7%
393	Cerebrospinal Fluid Otorrhea	2.7%
394	Cerebrospinal Fluid Rhinorrhea	2.7%
395	Neuritis, Autoimmune, Experimental	2.7%
396	Gait Ataxia	2.7%
397	Cerebellar Neoplasms	2.7%
398	Creutzfeldt-Jakob disease	2.6%
399	Basal Ganglia Cerebrovascular Disease	2.6%
400	Dementia, Vascular	2.6%
401	Brain Hemorrhage, Traumatic	2.6%
402	Welander Distal Myopathy	2.6%
403	Brain Injuries, Diffuse	2.6%
404	Traumatic Brain Injury	2.6%
405	Cerebellar Ataxia	2.6%
406	Supratentorial Neoplasms	2.6%
407	Torticollis	2.6%
408	Multiple Sclerosis, Chronic Progressive	2.6%
409	Multiple Sclerosis, Relapsing-Remitting	2.6%
410	Autoimmune Lymphoproliferative Syndrome	2.5%
411	Klinefelter Syndrome	2.5%
412	Congenital Hyperinsulinism	2.5%
413	Brain Diseases, Metabolic	2.5%
414	Cerebrovascular Disorders	2.5%
415	Myositis	2.5%
416	Optic Atrophy	2.5%
417	Optic Neuritis	2.5%
418	Papilledema	2.5%
419	Strabismus	2.5%
420	Tolosa-Hunt Syndrome	2.5%
421	Cerebrovascular Insufficiency	2.5%
422	Isaacs syndrome	2.5%
423	Arsenic Poisoning	2.5%
424	Dementia	2.5%
425	Myotonic Disorders	2.5%
426	Central Nervous System Fungal Infections	2.5%
427	Conus Medullaris Syndrome	2.5%
428	Spinal Cord Vascular Diseases	2.5%
429	Chorioamnionitis	2.5%
430	Familial Periodic Paralysis	2.5%
431	Angioedemas, Hereditary	2.5%
432	Long QT Syndrome	2.5%
433	Platybasia	2.5%
434	Tricuspid Atresia	2.5%
435	Arrhythmogenic Right Ventricular Dysplasia	2.5%
436	Brain Diseases, Metabolic, Inborn	2.5%
437	Diabetic Neuropathies	2.4%
438	Facial Injuries	2.4%
439	Facial Neuralgia	2.4%
440	Diabetic Amyotrophy	2.4%
441	Diabetic Autonomic Neuropathy	2.4%
442	Sleep Talking	2.4%
443	Manganese Poisoning	2.4%
444	Sleep Disorders, Intrinsic	2.4%
445	Orthostatic intolerance	2.4%
446	Gonadal Dysgenesis	2.4%
447	Bronchomalacia	2.4%
448	Adrenogenital Syndrome	2.4%
449	Alcohol Withdrawal Seizures	2.4%
450	Tracheomalacia	2.4%
451	Ovotesticular Disorders of Sex Development	2.4%
452	Anosmia	2.4%
453	Ataxia	2.4%
454	Athetosis	2.4%
455	Catalepsy	2.4%
456	Dystonia	2.4%
457	Hemiplegia	2.4%
458	Locked-In Syndrome	2.4%
459	Meningeal Neoplasms	2.4%
460	Muscle Hypertonia	2.4%
461	Muscle hypotonia	2.4%
462	Myoclonus	2.4%
463	Myotonia	2.4%
464	Neuralgia	2.4%
465	Paraplegia	2.4%
466	Pseudobulbar Palsy	2.4%
467	Quadriplegia	2.4%
468	Spasm	2.4%
469	Spastic Paraplegia	2.4%
470	Status Epilepticus	2.4%
471	Taste Disorders	2.4%
472	Tremor	2.4%
473	Monoplegia	2.4%
474	Hypokinesia	2.4%
475	Paraparesis	2.4%
476	Bradykinesia	2.4%
477	Waxy flexibility	2.4%
478	Action Tremor	2.4%
479	Resting Tremor	2.4%
480	Dysosmia	2.4%
481	Quadriparesis	2.4%
482	Mercury Poisoning, Nervous System	2.4%
483	Olfaction Disorders	2.4%
484	Myokymia	2.4%
485	Lead Poisoning, Nervous System	2.4%
486	Vestibular Neuronitis	2.4%
487	Somatosensory Disorders	2.4%
488	Neuropathic pain	2.4%
489	Hyperkinesia	2.4%
490	Intention tremor	2.4%
491	Carotid Artery Injuries	2.4%
492	Menkes Kinky Hair Syndrome	2.4%
493	Hyperkeratosis, Epidermolytic	2.4%
494	Myoclonic Epilepsy	2.4%
495	Epilepsy, Temporal Lobe	2.4%
496	Epilepsy, Rolandic	2.4%
497	Benign Rolandic Epilepsy	2.4%
498	Albinism	2.4%
499	Reflex, Abnormal	2.3%
500	Hyporeflexia	2.3%
501	Hyperreflexia	2.3%
502	Optic Atrophy, Hereditary, Leber	2.3%
503	Akathisia	2.3%
504	Restlessness	2.3%
505	Psychomotor Agitation	2.3%
506	Tuberculosis, Meningeal	2.3%
507	Carpal Tunnel Syndrome	2.3%
508	Vascular Headaches	2.3%
509	neurofibroma	2.2%
510	Hypoxia-Ischemia, Brain	2.2%
511	Sciatica	2.2%
512	Tardive Dyskinesia	2.2%
513	Persistent Vegetative State	2.2%
514	Cerebral Palsy	2.1%
515	Epilepsies, Partial	2.1%
516	Epilepsy, Generalized	2.1%
517	Pseudotumor Cerebri	2.1%
518	Sciatic Neuropathy	2.1%
519	Hypertensive Encephalopathy	2.1%
520	Ulnar Neuropathies	2.1%
521	Lesion of Sciatic Nerve	2.1%
522	Simple Partial Seizures	2.1%
523	Epilepsy, Reflex	2.1%
524	Ulnar Neuritis	2.1%
525	Radial nerve compression	2.1%
526	Radial Tunnel Syndrome	2.1%
527	Peroneal Neuropathies	2.1%
528	Radial Neuropathy	2.1%
529	Median Neuropathy	2.1%
530	Sciatic Nerve Palsy	2.1%
531	Femoral Neuropathy	2.1%
532	Tibial Neuropathy	2.1%
533	Ulnar Nerve Palsy	2.1%
534	Postural Orthostatic Tachycardia Syndrome	2.1%
535	Radial nerve palsy	2.1%
536	Headache Disorders, Primary	2.1%
537	Headache Disorders, Secondary	2.1%
538	Medication overuse headache	2.1%
539	Micrognathism	2.1%
540	Pierre Robin Syndrome	2.1%
541	Alice in Wonderland Syndrome	2.1%
542	Vertebral Artery Dissection	2.1%
543	Mucopolysaccharidosis II	2.1%
544	Amnesia, Transient Global	2.1%
545	Hand-Arm Vibration Syndrome	2.1%
546	Paralysis, Obstetric	2.1%
547	Retinopathy of Prematurity	2.1%
548	Gait Apraxia	2.1%
549	Amino Acid Metabolism, Inborn Errors	2%
550	Carbohydrate Metabolism, Inborn Errors	2%
551	Metal Metabolism, Inborn Errors	2%
552	Progeria	2%
553	Wiskott-Aldrich Syndrome	2%
554	Lysosomal Storage Diseases	2%
555	Cytochrome-c Oxidase Deficiency	2%
556	Peroxisomal Disorders	2%
557	Vision Disorders	2%
558	Metamorphopsia	2%
559	Visual Impairment	2%
560	Bronchopulmonary Dysplasia	2%
561	Fibromyalgia	2%
562	Optic Neuropathy, Ischemic	2%
563	Anterior Ischemic Optic Neuropathy	2%
564	Central Nervous System Bacterial Infections	2%
565	Medial Tibial Stress Syndrome	2%
566	Brain Concussion	2%
567	Optic Nerve Glioma	2%
568	Facial Hemiatrophy	2%
569	Melkersson-Rosenthal Syndrome	2%
570	Mitochondrial Myopathies	2%
571	Juvenile Myoclonic Epilepsy	2%
572	Myoclonic Epilepsies, Progressive	2%
573	Anisocoria	2%
574	Confusion	2%
575	Facial paralysis	2%
576	Lethargy	2%
577	Memory Disorders	2%
578	Muscle Cramp	2%
579	Perceptual Disorders	2%
580	Psychomotor Disorders	2%
581	Tonic Pupil	2%
582	Eosinophilia-Myalgia Syndrome	2%
583	Anhedonia	2%
584	Disorientation	2%
585	Facial Paresis	2%
586	Memory Loss	2%
587	Hemisensory Neglect	2%
588	Dysacusis	2%
589	Toxoplasmosis, Cerebral	2%
590	Sleep Bruxism	2%
591	Muscular Atrophy	2%
592	Respiratory Paralysis	2%
593	Tetany	1.9%
594	Aortopulmonary Septal Defect	1.9%
595	Double Outlet Right Ventricle	1.9%
596	Endocardial Cushion Defects	1.9%
597	Myocardial bridging	1.9%
598	Aorticopulmonary Septal Defect	1.9%
599	Hyperandrogenism	1.9%
600	Cubital Tunnel Syndrome	1.9%
601	Diffuse Axonal Injury	1.9%
602	Brain Stem Neoplasms	1.9%
603	Retrognathia	1.9%
604	Meningitis, Cryptococcal	1.9%
605	Meningitis, Listeria	1.9%
606	Meningitis, Haemophilus	1.9%
607	Meningitis, Pneumococcal	1.9%
608	Frontotemporal dementia	1.9%
609	Kernicterus	1.9%
610	Mitochondrial Encephalomyopathies	1.9%
611	Ophthalmia Neonatorum	1.8%
612	Galactosemias	1.8%
613	Urea Cycle Disorders, Inborn	1.8%
614	Tyrosinemias	1.8%
615	Pituitary Adenoma	1.8%
616	Pituitary Neoplasms	1.8%
617	Acoustic Neuroma	1.8%
618	MELAS Syndrome	1.7%
619	Prognathism	1.7%
620	Pituitary Diseases	1.7%
621	Basal Ganglia Hemorrhage	1.7%
622	Respiratory Distress Syndrome, Newborn	1.7%
623	Fabry Disease	1.7%
624	Consciousness Disorders	1.7%
625	Mental Retardation	1.7%
626	Muscle Weakness	1.7%
627	Depressed Level of Consciousness	1.7%
628	Mental deficiency	1.7%
629	Intellectual Disability	1.7%
630	Bell Palsy	1.7%
631	Cutis Laxa	1.7%
632	Catatonia	1.7%
633	Retinitis Pigmentosa	1.7%
634	Pigmentary retinopathy	1.7%
635	Herpes Zoster Oticus	1.6%
636	Thoracic Outlet Syndrome	1.6%
637	Porokeratosis	1.6%
638	Keratoderma, Palmoplantar	1.6%
639	Aphonia	1.6%
640	Sleep Deprivation	1.6%
641	Dysphonia	1.6%
642	Chronic granulomatous disease	1.6%
643	Pituitary Apoplexy	1.6%
644	Auditory Perceptual Disorders	1.6%
645	Carotid Artery Diseases	1.6%
646	Brain Ischemia	1.6%
647	Esotropia	1.6%
648	Exotropia	1.6%
649	Hypotension, Orthostatic	1.6%
650	Sleep Apnea Syndromes	1.6%
651	Cerebrovascular accident	1.6%
652	Polymyositis	1.6%
653	Kluver-Bucy Syndrome	1.6%
654	Vasospasm, Intracranial	1.6%
655	Spinal Cord Ischemia	1.6%
656	Intracranial Arterial Diseases	1.6%
657	Post-Exercise Hypotension	1.6%
658	Giant Cell Arteritis	1.6%
659	Temporal Arteritis	1.6%
660	Hypokalemic periodic paralysis	1.6%
661	Mandibulofacial Dysostosis	1.6%
662	Disorders of Excessive Somnolence	1.6%
663	Sleep Initiation and Maintenance Disorders	1.6%
664	Night Terrors	1.6%
665	Somnambulism	1.6%
666	Trigeminal Nerve Disorder	1.6%
667	Transient Insomnia	1.6%
668	Sleep Paralysis	1.6%
669	Chronic Insomnia	1.6%
670	REM Sleep Behavior Disorder	1.6%
671	Hypersomnia	1.6%
672	Romano-Ward Syndrome	1.6%
673	Brain Contusion	1.6%
674	Sickle Cell Trait	1.6%
675	Dysgeusia	1.6%
676	Formication	1.6%
677	Hyperalgesia	1.6%
678	Hyperesthesia	1.6%
679	Hypesthesia	1.6%
680	Language Disorders	1.6%
681	Numbness	1.6%
682	Paresthesia	1.6%
683	Paraparesis, Spastic	1.6%
684	Trismus	1.6%
685	Epilepsia Partialis Continua	1.6%
686	Hypogeusia	1.6%
687	Meningeal Carcinomatosis	1.6%
688	Brown-Sequard Syndrome	1.6%
689	Lockjaw	1.6%
690	Allodynia	1.6%
691	Lead Poisoning, Nervous System, Childhood	1.6%
692	Lead Poisoning, Nervous System, Adult	1.6%
693	Brain Infarction	1.6%
694	Ageusia	1.6%
695	Tuberculosis, Central Nervous System	1.6%
696	Polyradiculopathy	1.6%
697	Post-Traumatic Headache	1.6%
698	Tension Headache	1.6%
699	Epilepsy, Complex Partial	1.6%
700	Migraine Disorders	1.6%
701	Abdominal Migraine	1.6%
702	Status Migrainosus	1.6%
703	Cervicogenic Headache	1.6%
704	Subarachnoid Hemorrhage, Traumatic	1.6%
705	Carotid Artery, Internal, Dissection	1.6%
706	Choroid Plexus Papilloma	1.6%
707	Subacute Sclerosing Panencephalitis	1.5%
708	Homocystinuria	1.4%
709	Putaminal Hemorrhage	1.4%
710	Truncus Arteriosus, Persistent	1.4%
711	Leigh Disease	1.4%
712	Goldenhar Syndrome	1.4%
713	Myalgia	1.4%
714	Porphyrias, Hepatic	1.4%
715	Infarction, Middle Cerebral Artery	1.4%
716	Infarction, Anterior Cerebral Artery	1.4%
717	Infarction, Posterior Cerebral Artery	1.4%
718	Alexia	1.4%
719	Dyslexia	1.4%
720	Peutz-Jeghers Syndrome	1.4%
721	Thrombasthenia	1.4%
722	Antithrombin III Deficiency	1.4%
723	Protein C Deficiency	1.4%
724	Afibrinogenemia	1.4%
725	Factor VII Deficiency	1.4%
726	Factor X Deficiency	1.4%
727	Factor XII Deficiency	1.4%
728	Hemophilia A	1.4%
729	Activated Protein C Resistance	1.4%
730	Factor II deficiency	1.4%
731	Factor VIII Deficiency	1.4%
732	Factor V deficiency	1.4%
733	Factor XI Deficiency	1.4%
734	Hypoprothrombinemias	1.4%
735	Glycogen storage disease type II	1.4%
736	Fanconi Anemia	1.3%
737	Nesidioblastosis	1.3%
738	Eye Injuries	1.3%
739	Anemia, Diamond-Blackfan	1.3%
740	Cluster Headache	1.3%
741	Migraine with Aura	1.3%
742	Familial Hemiplegic Migraine	1.3%
743	Chronic Paroxysmal Hemicrania	1.3%
744	SUNCT Syndrome	1.3%
745	Paroxysmal Hemicrania	1.3%
746	Cerebral Infarction	1.3%
747	Brain Stem Infarctions	1.3%
748	Orbital Myositis	1.3%
749	Diplopia	1.3%
750	Muscle Rigidity	1.3%
751	Muscle Spasticity	1.3%
752	Scotoma	1.3%
753	Photophobia	1.3%
754	Cogwheel Rigidity	1.3%
755	Hemifacial Spasm	1.3%
756	Amaurosis	1.3%
757	Blindness	1.3%
758	Nuchal Rigidity	1.3%
759	Reye Syndrome	1.3%
760	Neuroaspergillosis	1.3%
761	Pyomyositis	1.3%
762	Hematoma, Subdural	1.3%
763	Hematoma, Epidural, Cranial	1.3%
764	Intracranial Embolism and Thrombosis	1.3%
765	Hepatic Encephalopathy	1.3%
766	Agnosia	1.3%
767	Apraxias	1.3%
768	Hallucinations	1.3%
769	Hemianopsia	1.3%
770	Hyperacusis	1.3%
771	Tinnitus	1.3%
772	Visual Agnosia	1.3%
773	Anosognosia	1.3%
774	Wernicke-Korsakoff Syndrome	1.3%
775	Phonophobia	1.3%
776	Hearing Loss	1.3%
777	Sarcopenia	1.3%
778	Hydrops Fetalis	1.3%
779	Moyamoya Disease	1.3%
780	Neurofibrosarcoma	1.2%
781	Hoarseness	1.2%
782	Acute Chest Syndrome	1.2%
783	Empty Sella Syndrome	1.2%
784	Hyperpituitarism	1.2%
785	Hypopituitarism	1.2%
786	Hypophysitis	1.2%
787	Alcohol Withdrawal Delirium	1.2%
788	Arteriovenous fistula	1.2%
789	Talipes	1.2%
790	Multiple Endocrine Neoplasia	1.2%
791	Alkaptonuria	1.2%
792	Glycogen Storage Disease	1.2%
793	Hypophosphatasia	1.2%
794	Propionic acidemia	1.2%
795	Dihydropyrimidine Dehydrogenase Deficiency	1.2%
796	Cystinosis	1.2%
797	Kearns-Sayre syndrome	1.2%
798	Cerebral Arterial Diseases	1.2%
799	Vertebrobasilar Insufficiency	1.2%
800	Anterior Spinal Artery Syndrome	1.2%
801	Basilar Artery Stenosis	1.2%
802	Vertebral Artery Stenosis	1.2%
803	Sleep Apnea, Obstructive	1.2%
804	Sleep Apnea, Central	1.2%
805	Intracranial Hemorrhage, Hypertensive	1.2%
806	Transient Cerebral Ischemia	1.2%
807	Narcolepsy	1.2%
808	Trigeminal Neuralgia	1.2%
809	Kleine-Levin Syndrome	1.2%
810	Agraphia	1.2%
811	Anomia	1.2%
812	Cluttering	1.2%
813	Language Development Disorders	1.2%
814	Speech Disorders	1.2%
815	Syncope	1.2%
816	Stupor	1.2%
817	Dysgraphia	1.2%
818	Presyncope	1.2%
819	Dyslalia	1.2%
820	Lateral Medullary Syndrome	1.2%
821	Congenital Hypothyroidism	1.2%
822	Dermatitis, Atopic	1.2%
823	West Nile Fever	1.2%
824	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
825	Pseudorabies	1.1%
826	Amnesia	1.1%
827	Delirium	1.1%
828	Dissociative Amnesia	1.1%
829	Color blindness	1.1%
830	Global Amnesia	1.1%
831	Meningioma	1.1%
832	Neurosyphilis	1.1%
833	Hyperphosphaturia	1.1%
834	Hematoma, Subdural, Intracranial	1%
835	Hematoma, Subdural, Chronic	1%
836	Hematoma, Subdural, Acute	1%
837	Behcet Syndrome	1%
838	Denys-Drash Syndrome	1%
839	Hyperprolactinemia	1%
840	Congenital clubfoot	1%
841	Vertical Talus	1%
842	Subclavian Steal Syndrome	1%
843	Pick Disease of the Brain	1%
844	Cataplexy	1%
845	Aphasia	1%
846	Articulation Disorders	1%
847	Echolalia	1%
848	Stuttering	1%
849	Dysphasia	1%
850	Eye Burns	1%
851	Hyaline Membrane Disease	1%
852	Malaria, Cerebral	1%
853	Gaucher Disease	1%
854	Carotid Stenosis	1%
855	Intracranial Aneurysm	1%
856	Hypolipoproteinemias	1%
857	Papillon-Lefevre Disease	1%
858	Neurocysticercosis	1%
859	Amaurosis Fugax	1%
860	Blindness, Cortical	1%
861	Dyscalculia	1%
862	Intracranial Arteriosclerosis	1%
863	Cerebral Atherosclerosis	1%
864	Hyperlipidemia, Familial Combined	1%
865	Subarachnoid Hemorrhage	1%
866	Cerebral Arteriosclerosis	1%
867	Cerebral Hemorrhage	1%
868	Hyperlipoproteinemia Type III	1%
869	Cerebral Thrombosis	1%
870	Intracranial Embolism	1%
871	Intracranial Thrombosis	1%
872	Deafness	1%
873	Hearing Loss, Sudden	1%
874	Gerstmann Syndrome	1%
875	Hearing Loss, Bilateral	1%
876	Hearing Loss, High-Frequency	1%
877	Hearing Loss, Mixed Conductive-Sensorineural	1%
878	Prosopagnosia	1%
879	Apraxia, Ideomotor	1%
880	Charles Bonnet Syndrome	1%
881	Hearing Loss, Unilateral	1%
882	Complete Hearing Loss	1%
883	Alien Hand Syndrome	1%
884	Deaf Mutism	1%
885	Wernicke Encephalopathy	0.9%
886	AIDS Dementia Complex	0.9%
887	Phantom pain	0.9%
888	Phantom Limb Pain	0.9%
889	Lyme Neuroborreliosis	0.9%
890	Mucopolysaccharidosis III	0.9%
891	Dysarthria	0.9%
892	Dermatomyositis	0.8%
893	Corneal Scar	0.8%
894	Nephroblastoma	0.8%
895	Mutism	0.8%
896	Selective Mutism	0.8%
897	Acromegaly	0.8%
898	Lactose Intolerance	0.8%
899	Variegate Porphyria	0.8%
900	Acute intermittent porphyria	0.8%
901	Porphyria Cutanea Tarda	0.8%
902	Hyperhomocysteinemia	0.8%
903	Waterhouse-Friderichsen Syndrome	0.8%
904	Retrograde amnesia	0.8%
905	Amnesia, Anterograde	0.8%
906	Renal Aminoacidurias	0.8%
907	Fanconi Syndrome	0.8%
908	Pseudohypoaldosteronism	0.8%
909	Liddle Syndrome	0.8%
910	Carotid Artery Thrombosis	0.8%
911	Hyperlipoproteinemia Type IV	0.8%
912	Hyperlipoproteinemia Type V	0.8%
913	Cerebral Amyloid Angiopathy	0.8%
914	Glycogen Storage Disease Type I	0.8%
915	Glycogen Storage Disease Type V	0.8%
916	Sinus Thrombosis, Intracranial	0.8%
917	Tay-Sachs Disease	0.8%
918	Niemann-Pick Disease, Type C	0.8%
919	Adenomatous Polyposis Coli	0.7%
920	Alexia, Pure	0.7%
921	Cavernous Sinus Thrombosis	0.7%
922	Sagittal Sinus Thrombosis	0.7%
923	Gout	0.7%
924	Multiple Endocrine Neoplasia Type 1	0.7%
925	Pseudohypoparathyroidism	0.7%
926	Renal tubular acidosis	0.7%
927	Corneal Perforation	0.7%
928	Hypoalphalipoproteinemias	0.6%
929	Nelson Syndrome	0.6%
930	Prolactinoma	0.6%
931	Growth Hormone-Secreting Pituitary Adenoma	0.6%
932	Glycosuria, Renal	0.5%
933	Cystinuria	0.5%
934	Arthritis, Gouty	0.5%
935	Familial Hypophosphatemic Rickets	0.5%

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