MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acrocephalosyndactylia

(UMLS:C1510455)

Definition:: Congenital craniostenosis with syndactyly.
UMLS ID:: C1510455
MeSH ID:: D000168

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.894.232.015|C05.116.099.370.894.819.100|C05.660.207.240.100|C05.660.585.800.100|C05.660.906.364.100|C05.660.906.819.100

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.240.100|C16.131.621.585.800.100|C16.131.621.906.364.100|C16.131.621.906.819.100

Synonym(s)

Acrocephalosyndactylia

ACROCEPHALOSYNDACTYLY

Acrocephalosyndactyly

Acrocephalosyndactyly, type I

Acroencephalosyndactyly

acrocephalopolysyndactyly

acrocephalosyndactyly

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	U 0126		17694057	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Poland Syndrome	58.1%
2	Pectus carinatum	45.8%
3	Arthrogryposis	45.7%
4	Klippel-Feil Syndrome	45.7%
5	Pectus excavatum	45.3%
6	Rubinstein-Taybi Syndrome	42.2%
7	Platybasia	40.4%
8	Antley-Bixler Syndrome Phenotype	40.4%
9	Craniosynostosis	38.4%
10	Syndactyly	38.4%
11	Brachycephaly	38.4%
12	Acrocephalosyndactylia	38.1%
13	Craniofacial Dysostosis	37.5%
14	Holoprosencephaly	37%
15	Gastroschisis	34.4%
16	Maxillofacial Abnormalities	31.6%
17	Limb Deformities, Congenital	28.5%
18	Craniofacial Abnormalities	28.5%
19	Amelia	28.4%
20	Arachnodactyly	28.4%
21	Ectromelia	28.4%
22	Hemimelia	28.4%
23	Phocomelia	28.4%
24	Sirenomelia	28.4%
25	Polydactyly	28.4%
26	Brachydactyly	28.4%
27	Plagiocephaly	28.4%
28	Lower Extremity Deformities, Congenital	28.4%
29	Upper Extremity Deformities, Congenital	28.4%
30	Microcephaly	27.1%
31	Macrocephaly	27.1%
32	Noonan Syndrome	25.2%
33	Jaw Abnormalities	23.7%
34	Mandibulofacial Dysostosis	22.6%
35	Laryngomalacia	21.5%
36	Marfan Syndrome	21%
37	Synostosis	20.2%
38	Osteoarthropathy, Secondary Hypertrophic	20%
39	Talipes	19.6%
40	Porencephaly	18.8%
41	Aicardi's syndrome	18.8%
42	Osteochondritis	18.5%
43	Nail-Patella Syndrome	17.8%
44	Goldenhar Syndrome	17.7%
45	Prognathism	17.4%
46	Beckwith-Wiedemann Syndrome	17.3%
47	Wolf-Hirschhorn Syndrome	17.3%
48	Gigantism	17.1%
49	Cleft Palate	16.8%
50	Multiple Epiphyseal Dysplasia	16.6%
51	Osteochondrodysplasias	16.6%
52	Micrognathism	16.2%
53	Pierre Robin Syndrome	16.2%
54	Smith-Magenis syndrome	16.2%
55	Cri-du-Chat Syndrome	16.1%
56	Down Syndrome	16.1%
57	Trisomy 21	16.1%
58	Basal Cell Nevus Syndrome	16%
59	Abnormalities, Drug-Induced	15.8%
60	Situs Inversus	15.8%
61	Fasciitis	15.6%
62	Foot Deformities	15.6%
63	Arthropathy	15.6%
64	Dwarfism	15.5%
65	Contracture	15.4%
66	Fasciitis, Plantar	15.4%
67	Retrognathia	15.3%
68	Cockayne Syndrome	15.3%
69	Ectodermal Dysplasia	15.1%
70	Aplasia Cutis Congenita	15.1%
71	Prader-Willi Syndrome	15%
72	Eye Abnormalities	14.8%
73	Cardiovascular Abnormalities	14.8%
74	Congenital clubfoot	14.7%
75	Vertical Talus	14.7%
76	Skin Abnormalities	14.6%
77	Lymphatic Abnormalities	14.6%
78	Congenital Microtia	14.6%
79	Gout	14.6%
80	Jaw Diseases	14.5%
81	Congenital diaphragmatic hernia	14.5%
82	Cartilage Diseases	14.4%
83	Foot Diseases	14.4%
84	Myopathy	14.4%
85	Rheumatism	14.4%
86	Chondromalacia	14.4%
87	Kartagener Syndrome	14.3%
88	Fibromyalgia	14.3%
89	Polymyalgia Rheumatica	14.3%
90	Metatarsalgia	14.2%
91	Urogenital Abnormalities	13.7%
92	Bronchomalacia	13.4%
93	Tracheomalacia	13.4%
94	Hyperostosis	13.3%
95	Osteitis	13.3%
96	Osteitis Deformans	13.3%
97	Osteochondrosis	13.3%
98	Spinal Diseases	13.3%
99	Congenital Hypothyroidism	13.2%
100	Spinal Neoplasms	12.6%
101	Spondylitis	12.6%
102	Bone Diseases, Endocrine	12.4%
103	Bone Diseases, Infectious	12.3%
104	Bone neoplasms	12.3%
105	Osteopenia	12.3%
106	Bone Resorption	12.2%
107	Aseptic Necrosis of Bone	12.2%
108	Temporomandibular Joint Disorders	12.1%
109	CHARGE Syndrome	12%
110	Anencephaly	11.9%
111	Abnormalities, Radiation-Induced	11.6%
112	Ischemic contracture	11.4%
113	Rheumatic Fever	11.2%
114	Xeroderma	11.1%
115	Mobius Syndrome	11.1%
116	Dural Arteriovenous Fistula	11.1%
117	Dextrocardia	11%
118	Osteoarthritis, Spine	11%
119	Osteogenesis Imperfecta	10.8%
120	Bone Diseases	10.7%
121	Rheumatoid Arthritis	10.5%
122	Juvenile arthritis	10.5%
123	Temporomandibular Joint Dysfunction Syndrome	10.3%
124	Genetic Diseases, Inborn	10.1%
125	Alstrom Syndrome	9.8%
126	Scimitar Syndrome	9.8%
127	Eosinophilic Granuloma	9.8%
128	Fetal Diseases	9.3%
129	Ichthyosis, X-Linked	9.2%
130	Polycystic Kidney Diseases	9.2%
131	Williams Syndrome	9.2%
132	Myotonic Dystrophy	8.9%
133	Arthritis, Gouty	8.9%
134	Hip Contracture	8.8%
135	Periarthritis	8.8%
136	Retinal Dysplasia	8.7%
137	Prune Belly Syndrome	8.7%
138	Twins, Conjoined	8.7%
139	Waardenburg Syndrome	8.7%
140	Aniridia	8.7%
141	Epidermolysis Bullosa	8.6%
142	Muscular Dystrophy	8.6%
143	Cystic Fibrosis	8.5%
144	Smith-Lemli-Opitz Syndrome	8.4%
145	Arthritis	8.3%
146	Bursitis	8.3%
147	Joint Instability	8.3%
148	Myofascial Pain Syndromes	8.3%
149	Rhabdomyolysis	8.3%
150	Synovitis	8.3%
151	Joint laxity	8.3%
152	Polyarthritis	8.3%
153	Frozen shoulder	8.3%
154	Patellofemoral Pain Syndrome	8.3%
155	Turner Syndrome	8.1%
156	Anophthalmos	8.1%
157	Anus, Imperforate	8.1%
158	Hydranencephaly	8.1%
159	Microphthalmos	8.1%
160	Neural Tube Defects	8.1%
161	Tethered Cord Syndrome	8.1%
162	Iniencephaly	8.1%
163	Craniorachischisis	8.1%
164	Exencephaly	8.1%
165	Septo-Optic Dysplasia	8.1%
166	Cortical Dysplasia	8.1%
167	Malformations of Cortical Development	8.1%
168	Anorectal Malformations	8.1%
169	Bloom Syndrome	8%
170	Familial Periodic Paralysis	8%
171	Meconium Aspiration Syndrome	7.9%
172	Ankylosing spondylitis	7.9%
173	Compartment syndromes	7.7%
174	Maxillary Diseases	7.7%
175	Tendinitis	7.7%
176	Tendinopathy	7.7%
177	Fragile X Syndrome	7.7%
178	Hemarthrosis	7.7%
179	Myositis	7.7%
180	Tietze's Syndrome	7.7%
181	Isaacs syndrome	7.7%
182	Myotonic Disorders	7.7%
183	Pseudoxanthoma Elasticum	7.7%
184	Discitis	7.6%
185	Blepharophimosis	7.5%
186	Laryngostenosis	7.5%
187	Mouth Abnormalities	7.5%
188	Esophageal Atresia	7.5%
189	Intestinal Atresia	7.5%
190	Horseshoe Kidney	7.5%
191	Acrodermatitis	7.4%
192	Lymphangiectasis, Intestinal	7.4%
193	Gianotti-Crosti Syndrome	7.4%
194	Ainhum	7.4%
195	Spinal Stenosis	7.4%
196	Spondylosis	7.4%
197	Intervertebral Disc Degeneration	7.4%
198	Chondrodysplasia Punctata	7.4%
199	Enchondromatosis	7.4%
200	Osteosclerosis	7.4%
201	Kashin-Beck Disease	7.4%
202	Arthritis, Psoriatic	7.3%
203	Xeroderma Pigmentosum	7.3%
204	Osteoarthritis, Knee	7.2%
205	Medial Tibial Stress Syndrome	7.1%
206	Sjogren-Larsson Syndrome	7.1%
207	Mitochondrial Myopathies	7.1%
208	Muscle Cramp	7.1%
209	Eosinophilia-Myalgia Syndrome	7.1%
210	Tuberculosis, Spinal	7.1%
211	Muscle Rigidity	7.1%
212	Muscle Spasticity	7.1%
213	Cogwheel Rigidity	7.1%
214	Nuchal Rigidity	7.1%
215	Choanal Atresia	7%
216	Tracheobronchomegaly	7%
217	Laryngocele	7%
218	Muscular Dystrophy, Duchenne	7%
219	Choledochal Cyst	7%
220	Hermaphroditism	7%
221	Disorders of Sex Development	7%
222	Cryptorchidism	7%
223	Hypospadias	7%
224	Central Nervous System Cysts	6.9%
225	Dandy-Walker Syndrome	6.9%
226	POEMS Syndrome	6.9%
227	Osteomyelitis	6.8%
228	Osteoporosis	6.8%
229	Periostitis	6.8%
230	Bone Demineralization, Pathologic	6.8%
231	Post-Traumatic Osteoporosis	6.8%
232	Alveolar Bone Loss	6.8%
233	Femur Head Necrosis	6.8%
234	Osteolysis	6.8%
235	Zellweger Syndrome	6.8%
236	Pseudohypoparathyroidism	6.8%
237	Chronic Fatigue Syndrome	6.7%
238	Rheumatoid Nodule	6.7%
239	Primary Ciliary Dyskinesia	6.6%
240	Giant Cell Epulis	6.6%
241	Muscle Weakness	6.6%
242	Musculoskeletal Pain	6.6%
243	Arthralgia	6.6%
244	Polyarthralgia	6.6%
245	Bladder Exstrophy	6.5%
246	Epispadias	6.5%
247	Multicystic Dysplastic Kidney	6.5%
248	Acromegaly	6.3%
249	Joint Tuberculosis	6.3%
250	Tuberculosis, Osteoarticular	6.3%
251	Bone Tuberculosis	6.3%
252	Felty Syndrome	6.2%
253	Myalgia	6.1%
254	Myotonia Congenita	6.1%
255	Kallmann Syndrome	6%
256	Arthritis, Reactive	5.9%
257	Rickets	5.9%
258	Bone Diseases, Developmental	5.9%
259	Rheumatoid Vasculitis	5.8%
260	Classical Lissencephalies and Subcortical Band Heterotopias	5.7%
261	Spondylarthropathies	5.6%
262	Tuberous Sclerosis	5.5%
263	Refsum Disease	5.5%
264	Polycystic Kidney, Autosomal Dominant	5.5%
265	Sicca Syndrome	5.4%
266	Sjogren's Syndrome	5.4%
267	Palatal Neoplasms	5.4%
268	Abdominal Cramps	5.3%
269	Amniotic Band Syndrome	5.3%
270	Asphyxia Neonatorum	5.3%
271	Infant, Premature, Diseases	5.3%
272	Infantile Colic	5.3%
273	Klinefelter Syndrome	5.3%
274	Charcot-Marie-Tooth Disease	5.1%
275	Welander Distal Myopathy	5%
276	Albinism	5%
277	Neoplastic Syndromes, Hereditary	4.9%
278	Anemia, Neonatal	4.8%
279	Pelger-Huet Anomaly	4.8%
280	Persistent Fetal Circulation Syndrome	4.8%
281	Werner Syndrome	4.8%
282	Myasthenic Syndromes, Congenital	4.8%
283	Umbilical hernia	4.8%
284	Ectopia Cordis	4.8%
285	Meningomyelocele	4.8%
286	Spina Bifida	4.8%
287	Single umbilical artery	4.8%
288	Bunion	4.8%
289	Fibrodysplasia Ossificans Progressiva	4.8%
290	Myoglobinuria	4.8%
291	Myositis Ossificans	4.8%
292	Tenosynovitis	4.8%
293	Sacroiliitis	4.8%
294	Hyperkeratosis, Epidermolytic	4.8%
295	Melorheostosis	4.8%
296	Osteopetrosis	4.8%
297	Hypokalemic periodic paralysis	4.7%
298	Anemia, Sickle Cell	4.6%
299	Thalassemia	4.6%
300	Neonatal Abstinence Syndrome	4.5%
301	Lordosis	4.5%
302	Spondylolysis	4.5%
303	kyphosis	4.5%
304	Fetal Growth Retardation	4.5%
305	Fetal Hypoxia	4.5%
306	Congenital nystagmus	4.5%
307	Fetal Alcohol Spectrum Disorders	4.5%
308	Toxoplasmosis, Congenital	4.5%
309	Aortic coarctation	4.4%
310	Cor Triatriatum	4.4%
311	Coronary Vessel Anomalies	4.4%
312	Dental Enamel Hypoplasia	4.4%
313	Patent ductus arteriosus	4.4%
314	Ebstein Anomaly	4.4%
315	Heart Septal Defects	4.4%
316	Hypodontia	4.4%
317	Macrostomia	4.4%
318	Meningocele	4.4%
319	Microstomia	4.4%
320	Syphilis, Congenital	4.4%
321	Tetralogy of Fallot	4.4%
322	Transposition of Great Vessels	4.4%
323	Hypoplastic Left Heart Syndrome	4.4%
324	May-Thurner Syndrome	4.4%
325	Encephalocele	4.4%
326	Arthritis, Infectious	4.4%
327	Wolff-Parkinson-White Syndrome	4.4%
328	Anterior Compartment Syndrome	4.4%
329	Enthesopathy	4.4%
330	Arthritis, Experimental	4.4%
331	Abdominal Compartment Syndrome	4.4%
332	Polymyositis	4.4%
333	Hyperandrogenism	4.3%
334	Autoimmune Lymphoproliferative Syndrome	4.2%
335	Congenital Hyperinsulinism	4.2%
336	Chorioamnionitis	4.2%
337	Angioedemas, Hereditary	4.1%
338	Long QT Syndrome	4.1%
339	Tricuspid Atresia	4.1%
340	Arrhythmogenic Right Ventricular Dysplasia	4.1%
341	Gonadal Dysgenesis	4.1%
342	Adrenogenital Syndrome	4.1%
343	Ovotesticular Disorders of Sex Development	4.1%
344	Hip Dislocation	4.1%
345	Shoulder Dislocation	4.1%
346	Hip Dysplasia	4.1%
347	Osteoporosis, Postmenopausal	4.1%
348	Orbital Myositis	4.1%
349	Dupuytren Contracture	4.1%
350	Pyomyositis	4.1%
351	Wiskott-Aldrich Syndrome	4%
352	Menkes Kinky Hair Syndrome	3.8%
353	Mastoiditis	3.8%
354	Petrositis	3.8%
355	Shoulder Pain	3.8%
356	Ophthalmia Neonatorum	3.6%
357	Mucopolysaccharidosis II	3.5%
358	Mitochondrial Encephalomyopathies	3.5%
359	Osteomalacia	3.5%
360	Dysostoses	3.5%
361	Ataxia Telangiectasia	3.5%
362	Adrenoleukodystrophy	3.5%
363	Hepatolenticular Degeneration	3.4%
364	Dermal Sinus	3.2%
365	Spina Bifida Cystica	3.2%
366	Spina Bifida Occulta	3.2%
367	Lissencephaly	3.2%
368	Polymicrogyria	3.2%
369	Pachygyria	3.2%
370	Schizencephaly	3.2%
371	Periventricular Nodular Heterotopia	3.2%
372	Spondylolisthesis	3%
373	Amyloid Neuropathies, Familial	3%
374	Neuronal Ceroid-Lipofuscinoses	3%
375	Nose Neoplasms	3%
376	Aortopulmonary Septal Defect	2.9%
377	Double Outlet Right Ventricle	2.9%
378	Endocardial Cushion Defects	2.9%
379	Rett Syndrome	2.9%
380	Myocardial bridging	2.9%
381	Aorticopulmonary Septal Defect	2.9%
382	Renal Osteodystrophy	2.9%
383	Renal rickets	2.9%
384	Familial Mediterranean Fever	2.9%
385	MELAS Syndrome	2.8%
386	Fabry Disease	2.7%
387	Romano-Ward Syndrome	2.7%
388	Sickle Cell Trait	2.7%
389	Paralysis, Obstetric	2.7%
390	Retinopathy of Prematurity	2.7%
391	Amino Acid Metabolism, Inborn Errors	2.7%
392	Carbohydrate Metabolism, Inborn Errors	2.7%
393	Metal Metabolism, Inborn Errors	2.7%
394	Progeria	2.7%
395	Lysosomal Storage Diseases	2.7%
396	Cytochrome-c Oxidase Deficiency	2.7%
397	Peroxisomal Disorders	2.7%
398	Familial Hypophosphatemic Rickets	2.7%
399	Bronchopulmonary Dysplasia	2.7%
400	Hydrops Fetalis	2.7%
401	Denys-Drash Syndrome	2.6%
402	Respiratory Distress Syndrome, Newborn	2.5%
403	Canavan Disease	2.5%
404	Alexander Disease	2.5%
405	Cutis Laxa	2.5%
406	Retinitis Pigmentosa	2.5%
407	Pigmentary retinopathy	2.5%
408	Porokeratosis	2.5%
409	Keratoderma, Palmoplantar	2.5%
410	Chronic granulomatous disease	2.5%
411	Dermatomyositis	2.4%
412	Acute Chest Syndrome	2.4%
413	Arteriovenous fistula	2.4%
414	Galactosemias	2.4%
415	Urea Cycle Disorders, Inborn	2.4%
416	Tyrosinemias	2.4%
417	Duane Retraction Syndrome	2.3%
418	Porphyrias, Hepatic	2.3%
419	Peutz-Jeghers Syndrome	2.3%
420	Thrombasthenia	2.3%
421	Antithrombin III Deficiency	2.3%
422	Protein C Deficiency	2.3%
423	Brain Diseases, Metabolic, Inborn	2.3%
424	Afibrinogenemia	2.3%
425	Dystonia Musculorum Deformans	2.3%
426	Factor VII Deficiency	2.3%
427	Factor X Deficiency	2.3%
428	Factor XII Deficiency	2.3%
429	Hemophilia A	2.3%
430	Leukomalacia, Periventricular	2.3%
431	Activated Protein C Resistance	2.3%
432	Factor II deficiency	2.3%
433	Factor VIII Deficiency	2.3%
434	Factor V deficiency	2.3%
435	Factor XI Deficiency	2.3%
436	Hypoprothrombinemias	2.3%
437	Fanconi Anemia	2.3%
438	Nesidioblastosis	2.3%
439	Lafora Disease	2.3%
440	Unverricht-Lundborg Syndrome	2.3%
441	Anemia, Diamond-Blackfan	2.3%
442	Optic Atrophy, Hereditary, Leber	2.3%
443	Hyperphosphaturia	2.3%
444	Truncus Arteriosus, Persistent	2.2%
445	Multiple Endocrine Neoplasia	2.2%
446	Dermatitis, Atopic	2.2%
447	Glycogen storage disease type II	2.1%
448	Kernicterus	2%
449	Behcet Syndrome	2%
450	Huntington Disease	1.9%
451	Homocystinuria	1.9%
452	Leigh Disease	1.9%
453	Nephroblastoma	1.8%
454	Mucopolysaccharidosis III	1.7%
455	Adenomatous Polyposis Coli	1.7%
456	Kearns-Sayre syndrome	1.7%
457	Radicular Cyst	1.6%
458	Alkaptonuria	1.6%
459	Glycogen Storage Disease	1.6%
460	Hypophosphatasia	1.6%
461	Propionic acidemia	1.6%
462	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
463	Cystinosis	1.6%
464	Gaucher Disease	1.5%
465	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.5%
466	Hyaline Membrane Disease	1.5%
467	Hypolipoproteinemias	1.5%
468	Papillon-Lefevre Disease	1.5%
469	Hyperlipidemia, Familial Combined	1.5%
470	Hyperlipoproteinemia Type III	1.5%
471	Lactose Intolerance	1.4%
472	Variegate Porphyria	1.4%
473	Acute intermittent porphyria	1.4%
474	Porphyria Cutanea Tarda	1.4%
475	Hyperhomocysteinemia	1.4%
476	Renal Aminoacidurias	1.4%
477	Fanconi Syndrome	1.4%
478	Pseudohypoaldosteronism	1.4%
479	Liddle Syndrome	1.4%
480	Hyperlipoproteinemia Type IV	1.4%
481	Hyperlipoproteinemia Type V	1.4%
482	Multiple Endocrine Neoplasia Type 1	1.3%
483	Friedreich Ataxia	1.3%
484	Renal tubular acidosis	1.3%
485	Niemann-Pick Disease, Type C	1.2%
486	Glycosuria, Renal	1.1%
487	Tay-Sachs Disease	1.1%
488	Glycogen Storage Disease Type I	1.1%
489	Glycogen Storage Disease Type V	1.1%
490	Hypoalphalipoproteinemias	1%
491	Cystinuria	0.9%

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