MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vascular calcification

(UMLS:C0342649)

Definition:: Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
UMLS ID:: C0342649
MeSH ID:: D061205

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.174.130.780

Synonym(s)

Vascular calcification

VASCULAR CALCIFICATION

Vascular Calcification

calcifications vascular

vascular calcification

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 20		US FAERS
2	Teriparatide	FAERS: 14		US FAERS
3	rofecoxib	FAERS: 12		OFFSIDES US FAERS
4	Sitagliptin Phosphate	FAERS: 11		US FAERS
5	Warfarin	FAERS: 8	View details 10669626 21705322 23117658 23223575 23990204 27212383 27412937	CTD US FAERS
6	Zoledronic Acid	FAERS: 5		OFFSIDES US FAERS
7	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 4		US FAERS
8	Imatinib Mesylate	FAERS: 4		US FAERS
9	Rosiglitazone	FAERS: 4		US FAERS
10	Rosuvastatin Calcium	FAERS: 4		US FAERS
11	Warfarin	FAERS: 4		US FAERS
12	paricalcitol	FAERS: 4		OFFSIDES US FAERS
13	Atorvastatin	FAERS: 3		US FAERS
14	Lenalidomide	FAERS: 3		US FAERS
15	gemcitabine	FAERS: 3		US FAERS
16	Cinacalcet	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
17	Ezetimibe, Simvastatin Drug Combination	FAERS: 2		US FAERS
18	Melphalan	FAERS: 2		US FAERS
19	Paclitaxel	FAERS: 2		US FAERS
20	Paroxetine	FAERS: 2		US FAERS
21	Rivastigmine	FAERS: 2		OFFSIDES US FAERS
22	Sorafenib	FAERS: 2		US FAERS
23	Valacyclovir	FAERS: 2		US FAERS
24	apixaban	FAERS: 2		US FAERS
25	salmon calcitonin	FAERS: 2		US FAERS
26	Amlodipine	FAERS: 1		US FAERS
27	Anastrozole	FAERS: 1		US FAERS
28	Bortezomib	FAERS: 1		OFFSIDES US FAERS
29	Calcitriol	FAERS: 1		US FAERS
30	Calcium Gluconate	FAERS: 1		US FAERS
31	Digoxin	FAERS: 1		US FAERS
32	Eptifibatide	FAERS: 1		OFFSIDES US FAERS
33	Esomeprazole	FAERS: 1		US FAERS
34	Estrogens, Conjugated (USP)	FAERS: 1		US FAERS
35	Exenatide	FAERS: 1		US FAERS
36	Finasteride	FAERS: 1		US FAERS
37	Hydrochlorothiazide	FAERS: 1		US FAERS
38	Hydroxychloroquine	FAERS: 1		US FAERS
39	Midodrine	FAERS: 1		US FAERS
40	Omeprazole	FAERS: 1		US FAERS
41	Penicillin G	FAERS: 1		US FAERS
42	Pregabalin	FAERS: 1		US FAERS
43	Raloxifene Hydrochloride	FAERS: 1		US FAERS
44	Ranolazine	FAERS: 1		US FAERS
45	Sertraline	FAERS: 1		OFFSIDES US FAERS
46	Sevelamer	FAERS: 1		US FAERS
47	Simvastatin	FAERS: 1		US FAERS
48	Tadalafil	FAERS: 1		US FAERS
49	Tiotropium Bromide	FAERS: 1		US FAERS
50	Valacyclovir	FAERS: 1		US FAERS
51	Valsartan	FAERS: 1		US FAERS
52	gadodiamide	FAERS: 1		US FAERS
53	ivacaftor	FAERS: 1		US FAERS
54	pazopanib	FAERS: 1		US FAERS
55	5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride			OFFSIDES
56	Acetaminophen			OFFSIDES
57	Acyclovir			OFFSIDES
58	Alprostadil			OFFSIDES
59	Aztreonam			OFFSIDES
60	Betaxolol			OFFSIDES
61	Bimatoprost			OFFSIDES
62	Bupropion			OFFSIDES
63	Buspirone			OFFSIDES
64	Caffeine			OFFSIDES
65	Chlorambucil			OFFSIDES
66	Cilostazol			OFFSIDES
67	Cimetidine			OFFSIDES
68	Codeine			OFFSIDES
69	Dexamethasone			OFFSIDES
70	Dihydrotestosterone		20048160	CTD
71	Estradiol			OFFSIDES
72	Famciclovir			OFFSIDES
73	Flurazepam			OFFSIDES
74	Formoterol Fumarate			OFFSIDES
75	Fulvestrant			OFFSIDES
76	Goserelin			OFFSIDES
77	Hydroxyurea			OFFSIDES
78	Indomethacin			OFFSIDES
79	Ketoconazole			OFFSIDES
80	Labetalol			OFFSIDES
81	Letrozole			OFFSIDES
82	Lidoderm			OFFSIDES
83	Losartan			OFFSIDES
84	Medroxyprogesterone Acetate			OFFSIDES
85	Melatonin			OFFSIDES
86	Methylprednisolone Acetate			OFFSIDES
87	Metoclopramide			OFFSIDES
88	Metolazone			OFFSIDES
89	Metronidazole			OFFSIDES
90	Minoxidil			OFFSIDES
91	Nicergoline			OFFSIDES
92	Nitrendipine		6085384	CTD
93	Nortriptyline			OFFSIDES
94	Ofloxacin			OFFSIDES
95	Olanzapine			OFFSIDES
96	Ondansetron			OFFSIDES
97	Orphenadrine			OFFSIDES
98	Palmitic Acid		24080574	CTD
99	Pamidronate			OFFSIDES
100	Phosphates		20048160 23104429	CTD
101	Pioglitazone			OFFSIDES
102	Piperacillin, Tazobactam Drug Combination			OFFSIDES
103	Progesterone			OFFSIDES
104	Quercetin		23117658 23223575	CTD
105	Quinidine			OFFSIDES
106	Rifaximin			OFFSIDES
107	Risedronic Acid			OFFSIDES
108	Scopolamine			OFFSIDES
109	Sevelamer			OFFSIDES
110	Sevelamer			OFFSIDES
111	Sirolimus			OFFSIDES
112	Sumatriptan			OFFSIDES
113	Tamoxifen			OFFSIDES
114	Temazepam			OFFSIDES
115	Terazosin			OFFSIDES
116	Testosterone		20048160	CTD
117	Tetracycline			OFFSIDES
118	Tobramycin			OFFSIDES
119	Trimetazidine			OFFSIDES
120	Venlafaxine Hydrochloride			OFFSIDES
121	Vitamin D		23104429	CTD
122	Vitamin K 1		23990204 27412937	CTD
123	acetovanillone		24080574	CTD
124	benazepril			OFFSIDES
125	beraprost			OFFSIDES
126	calcium acetate			OFFSIDES
127	chlorhexidine gluconate			OFFSIDES
128	dexamethasone acetate			OFFSIDES
129	dolasetron			OFFSIDES
130	exemestane			OFFSIDES
131	gadoversetamide			OFFSIDES
132	mecobalamin			OFFSIDES
133	reviparin			OFFSIDES
134	sodium arsenite		23104429	CTD
135	tegaserod			OFFSIDES
136	tegaserod			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Calciphylaxis	48.4%
2	Hypercalcemia	33%
3	Hypocalcemia	33%
4	Milk-Alkali Syndrome	33%
5	Acid-Base Imbalance	25.4%
6	Iron Metabolism Disorders	25.4%
7	Phosphorus Metabolism Disorders	25.4%
8	Water-Electrolyte Imbalance	25.4%
9	Lipid Metabolism Disorders	25.4%
10	Mitochondrial Diseases	25.4%
11	Glucose Metabolism Disorders	25.4%
12	Nephrocalcinosis	24.4%
13	Wasting Syndrome	23%
14	Rickets	20.5%
15	Pseudohypoparathyroidism	19.7%
16	Osteopenia	17.2%
17	Brain Diseases, Metabolic	16.9%
18	Nutrition Disorders	16.4%
19	Lipodystrophy	14.9%
20	Acidosis	14.8%
21	Alkalosis	14.8%
22	Amyloidosis	14.8%
23	Hyperglycemia	14.8%
24	Hyperinsulinism	14.8%
25	Hyperkalemia	14.8%
26	Hypernatremia	14.8%
27	Hypoglycemia	14.8%
28	Hypokalemia	14.8%
29	Hyponatremia	14.8%
30	Xanthomatosis	14.8%
31	Hypophosphatemia	14.8%
32	Metabolic acidosis	14.8%
33	Dyslipidemias	14.8%
34	Iron Overload	14.8%
35	Xanthoma	14.8%
36	CREST Syndrome	13.9%
37	Osteomalacia	13.6%
38	Brain Diseases, Metabolic, Inborn	11.8%
39	Tetany	11.4%
40	Diabetes Mellitus	10.6%
41	Hyperhomocysteinemia	10.5%
42	Leigh Disease	10.3%
43	Dehydration	10.1%
44	Lipomatosis	10.1%
45	Water Intoxication	10.1%
46	Werner Syndrome	10.1%
47	Achlorhydria	9.9%
48	Amino Acid Metabolism, Inborn Errors	9.9%
49	Bloom Syndrome	9.9%
50	Carbohydrate Metabolism, Inborn Errors	9.9%
51	Metal Metabolism, Inborn Errors	9.9%
52	Osteoporosis	9.9%
53	Progeria	9.9%
54	Lysosomal Storage Diseases	9.9%
55	Bone Demineralization, Pathologic	9.9%
56	Cytochrome-c Oxidase Deficiency	9.9%
57	Peroxisomal Disorders	9.9%
58	Post-Traumatic Osteoporosis	9.9%
59	Celiac Disease	9.8%
60	Sprue, Tropical	9.8%
61	Steatorrhea	9.8%
62	Sprue	9.8%
63	Lactose Intolerance	9.7%
64	Acidosis, Lactic	9.7%
65	Hemosiderosis	9.7%
66	Hypolipoproteinemias	9.7%
67	Ketosis	9.7%
68	Ketonuria	9.7%
69	Ketoacidosis	9.7%
70	Ketonemia	9.7%
71	Carbamoyl-Phosphate Synthase I Deficiency Disease	9%
72	Hyperlipoproteinemia Type IV	8.6%
73	Hyperlipoproteinemia Type V	8.6%
74	Renal Osteodystrophy	8.5%
75	Renal rickets	8.5%
76	Diabetic Ketoacidosis	8.5%
77	Child Nutrition Disorders	8.5%
78	Hypervitaminosis A	8.5%
79	Infant Nutrition Disorders	8.5%
80	Malnutrition	8.5%
81	Hyperlipidemia, Familial Combined	8.4%
82	Smith-Lemli-Opitz Syndrome	8.3%
83	Familial Hypophosphatemic Rickets	8.3%
84	Galactosemias	8.3%
85	Urea Cycle Disorders, Inborn	8.3%
86	Tyrosinemias	8.3%
87	Mitochondrial Encephalomyopathies	8.2%
88	Congenital Hyperinsulinism	8.1%
89	Hyperlipoproteinemia Type III	7.8%
90	Mitochondrial Myopathies	7.6%
91	Myelinolysis, Central Pontine	7.5%
92	Glycosuria	7.4%
93	Reye Syndrome	7.4%
94	Hepatic Encephalopathy	7.3%
95	Hyperphosphaturia	7.2%
96	Hypercholesterolemia	7.2%
97	Hyperlipoproteinemias	7.2%
98	Hypertriglyceridemia	7.2%
99	Hypoalphalipoproteinemias	7.2%
100	Homocystinuria	6.7%
101	HIV Wasting Syndrome	6.5%
102	Acidosis, Respiratory	6.5%
103	Adiposis Dolorosa	6.5%
104	Alkalosis, Respiratory	6.5%
105	Alkaptonuria	6.5%
106	Glycogen Storage Disease	6.5%
107	Hypophosphatasia	6.5%
108	Insulin Resistance	6.5%
109	Osteoporosis, Postmenopausal	6.5%
110	Propionic acidemia	6.5%
111	Dihydropyrimidine Dehydrogenase Deficiency	6.5%
112	Cystinosis	6.5%
113	Renal tubular acidosis	6.4%
114	Glycogen storage disease type II	6.4%
115	Gaucher Disease	6.2%
116	Amyloid Neuropathies, Familial	6.1%
117	Porphyrias, Hepatic	6%
118	Necrobiosis Lipoidica Diabeticorum	5.9%
119	Fanconi Anemia	5.8%
120	Nesidioblastosis	5.8%
121	Neuronal Ceroid-Lipofuscinoses	5.7%
122	HIV-Associated Lipodystrophy Syndrome	5.5%
123	Wernicke Encephalopathy	5.5%
124	Zellweger Syndrome	5.3%
125	MELAS Syndrome	5.3%
126	Menkes Kinky Hair Syndrome	5.3%
127	Adrenoleukodystrophy	5.1%
128	Gestational Diabetes	5.1%
129	Latent Autoimmune Diabetes in Adults	5.1%
130	Tay-Sachs Disease	5.1%
131	Diabetes Mellitus, Experimental	5%
132	Niemann-Pick Disease, Type C	4.9%
133	Deficiency Diseases	4.9%
134	Starvation	4.9%
135	Refeeding Syndrome	4.9%
136	Hepatolenticular Degeneration	4.9%
137	Friedreich Ataxia	4.9%
138	Refsum Disease	4.8%
139	Glycosuria, Renal	4.8%
140	Cerebral Amyloid Angiopathy	4.8%
141	Glycogen Storage Disease Type I	4.8%
142	Glycogen Storage Disease Type V	4.8%
143	Mucopolysaccharidosis III	4.8%
144	Fabry Disease	4.8%
145	Kernicterus	4.3%
146	Cockayne Syndrome	4.2%
147	Familial Periodic Paralysis	4%
148	Primary amyloidosis	3.9%
149	Kearns-Sayre syndrome	3.9%
150	Variegate Porphyria	3.9%
151	Acute intermittent porphyria	3.9%
152	Porphyria Cutanea Tarda	3.9%
153	Renal Aminoacidurias	3.9%
154	Fanconi Syndrome	3.9%
155	Pseudohypoaldosteronism	3.9%
156	Liddle Syndrome	3.9%
157	Ataxia Telangiectasia	3.8%
158	Optic Atrophy, Hereditary, Leber	3.7%
159	Sjogren-Larsson Syndrome	3.4%
160	Xeroderma Pigmentosum	3.3%
161	Gout	3.3%
162	Amyotrophic Lateral Sclerosis	3.3%
163	Antley-Bixler Syndrome Phenotype	3.2%
164	Canavan Disease	3.2%
165	Alexander Disease	3.2%
166	Kwashiorkor	3.2%
167	Magnesium Deficiency	3.2%
168	Potassium Deficiency	3.2%
169	Protein Deficiency	3.2%
170	Avitaminosis	3.2%
171	Mucopolysaccharidosis II	3.2%
172	Hypokalemic periodic paralysis	2.9%
173	Frontotemporal dementia	2.9%
174	Cystinuria	2.9%
175	Albinism	2.5%
176	Arthritis, Gouty	2.4%
177	Ascorbic Acid Deficiency	2.4%
178	Vitamin A Deficiency	2.4%
179	Vitamin D Deficiency	2.4%
180	Vitamin E Deficiency	2.4%
181	Marasmus	2.4%
182	Folic Acid Deficiency	2%
183	Pellagra	2%
184	Thiamine Deficiency	2%
185	Vitamin B 12 Deficiency	2%
186	Vitamin B 6 Deficiency	2%
187	Pyridoxine Deficiency	2%
188	Ichthyosis, X-Linked	2%
189	Obesity	1.9%
190	Beriberi	1.8%
191	Obesity, Abdominal	1.6%
192	Pediatric Obesity	1.3%
193	Vitamin K Deficiency	1.2%
194	Anemia, Pernicious	1.2%
195	Prader-Willi Syndrome	1.1%
196	Scurvy	1%
197	Subacute Combined Degeneration	0.6%

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