MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Congenital clubfoot

(UMLS:C0009081)

Definition:: A deformed foot in which the foot is plantarflexed, inverted, and adducted.
UMLS ID:: C0009081
MeSH ID:: D003025

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.330.488.655.063|C05.330.495.681.063|C05.660.585.512.380.813.063

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.512.500.681.063

Synonym(s)

Congenital clubfoot

CLUB FOOT

CLUBBED FOOT

CLUBFOOT

CLUBFOOT, CONGENITAL, WITH OR WITHOUT DEFICIENCY OF LONG BONES AND/OR MIRROR-IMAGE POLYDACTYLY

CTEV - Congenital talipes equinovarus

Club Foot

Club feet

Club foot

10.

Clubbed Foot

11.

Clubfeet

12.

Clubfoot

13.

Clubfoot - congenital

14.

Clubfoot, NOS

15.

Congenital talipes equinovarus

16.

Equinovarus

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Clomiphene			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Vertical Talus	55.8%
2	Arthrogryposis	27.6%
3	Syndactyly	22.6%
4	Pectus carinatum	22.1%
5	Pectus excavatum	21.5%
6	Bunion	20.7%
7	Amelia	20.7%
8	Arachnodactyly	20.7%
9	Ectromelia	20.7%
10	Hemimelia	20.7%
11	Phocomelia	20.7%
12	Sirenomelia	20.7%
13	Polydactyly	20.7%
14	Brachydactyly	20.7%
15	Upper Extremity Deformities, Congenital	20.7%
16	Craniofacial Abnormalities	20.5%
17	Klippel-Feil Syndrome	20%
18	Synostosis	20%
19	Bone Diseases	17.5%
20	Fasciitis	17.5%
21	Arthropathy	17.5%
22	Gastroschisis	17.5%
23	Craniosynostosis	16.1%
24	Brachycephaly	16.1%
25	Contracture	15.7%
26	Osteoarthropathy, Secondary Hypertrophic	15.7%
27	Fasciitis, Plantar	15.7%
28	Jaw Diseases	15.1%
29	Platybasia	15.1%
30	Cartilage Diseases	14.8%
31	Foot Diseases	14.8%
32	Myopathy	14.8%
33	Rheumatism	14.8%
34	Chondromalacia	14.8%
35	Acrocephalosyndactylia	14.7%
36	Fibromyalgia	13.5%
37	Osteochondritis	13.5%
38	Polymyalgia Rheumatica	13.5%
39	Metatarsalgia	13.4%
40	Poland Syndrome	13.2%
41	Rubinstein-Taybi Syndrome	12%
42	Craniofacial Dysostosis	11.9%
43	Gout	11.6%
44	Holoprosencephaly	11.5%
45	Plagiocephaly	11.1%
46	Maxillofacial Abnormalities	11%
47	Laryngomalacia	10.8%
48	Rheumatic Fever	10.5%
49	Temporomandibular Joint Disorders	10.3%
50	Talipes	10.2%
51	Nail-Patella Syndrome	10.2%
52	Ischemic contracture	10.1%
53	Jaw Abnormalities	9.8%
54	Rheumatoid Arthritis	9.3%
55	Juvenile arthritis	9.3%
56	Arthritis	9.3%
57	Bone Diseases, Developmental	9.3%
58	Bursitis	9.3%
59	Hyperostosis	9.3%
60	Joint Instability	9.3%
61	Myofascial Pain Syndromes	9.3%
62	Osteitis	9.3%
63	Osteitis Deformans	9.3%
64	Osteochondrosis	9.3%
65	Rhabdomyolysis	9.3%
66	Spinal Diseases	9.3%
67	Synovitis	9.3%
68	Joint laxity	9.3%
69	Polyarthritis	9.3%
70	Frozen shoulder	9.3%
71	Patellofemoral Pain Syndrome	9.3%
72	Antley-Bixler Syndrome Phenotype	9.1%
73	Microcephaly	9%
74	Macrocephaly	9%
75	Osteoarthritis, Spine	9%
76	Hip Contracture	8.9%
77	Periarthritis	8.9%
78	Temporomandibular Joint Dysfunction Syndrome	8.3%
79	Abnormalities, Drug-Induced	8.1%
80	Situs Inversus	8.1%
81	Bone Diseases, Endocrine	8%
82	Noonan Syndrome	7.9%
83	Bone Diseases, Infectious	7.8%
84	Bone neoplasms	7.8%
85	Compartment syndromes	7.8%
86	Maxillary Diseases	7.8%
87	Osteopenia	7.8%
88	Tendinitis	7.8%
89	Tendinopathy	7.8%
90	Bone Resorption	7.8%
91	Hemarthrosis	7.8%
92	Myositis	7.8%
93	Tietze's Syndrome	7.8%
94	Isaacs syndrome	7.8%
95	Aseptic Necrosis of Bone	7.8%
96	Myotonic Disorders	7.8%
97	Gigantism	7.7%
98	Spinal Neoplasms	7.7%
99	Spondylitis	7.7%
100	Osteoarthritis, Knee	7.2%
101	Prognathism	7.1%
102	Eye Abnormalities	7%
103	Cardiovascular Abnormalities	7%
104	Arthritis, Gouty	6.9%
105	Beckwith-Wiedemann Syndrome	6.9%
106	Wolf-Hirschhorn Syndrome	6.9%
107	Ankylosing spondylitis	6.9%
108	Skin Abnormalities	6.8%
109	Lymphatic Abnormalities	6.8%
110	Congenital Microtia	6.8%
111	Congenital clubfoot	6.8%
112	Multiple Epiphyseal Dysplasia	6.7%
113	Osteochondrodysplasias	6.7%
114	Medial Tibial Stress Syndrome	6.7%
115	Congenital diaphragmatic hernia	6.7%
116	Mitochondrial Myopathies	6.7%
117	Marfan Syndrome	6.7%
118	Muscle Cramp	6.6%
119	Eosinophilia-Myalgia Syndrome	6.6%
120	Aicardi's syndrome	6.6%
121	Muscle Rigidity	6.6%
122	Muscle Spasticity	6.6%
123	Cogwheel Rigidity	6.6%
124	Nuchal Rigidity	6.6%
125	Bronchomalacia	6.5%
126	Tracheomalacia	6.5%
127	Mandibulofacial Dysostosis	6.4%
128	Familial Periodic Paralysis	6.3%
129	Rheumatoid Nodule	6.2%
130	Smith-Magenis syndrome	6.1%
131	Chronic Fatigue Syndrome	6%
132	Cri-du-Chat Syndrome	6%
133	Down Syndrome	6%
134	Trisomy 21	6%
135	Urogenital Abnormalities	6%
136	Arthritis, Psoriatic	6%
137	Dwarfism	6%
138	Giant Cell Epulis	5.9%
139	Muscle Weakness	5.9%
140	Musculoskeletal Pain	5.8%
141	Micrognathism	5.8%
142	Pierre Robin Syndrome	5.8%
143	Arthralgia	5.8%
144	Polyarthralgia	5.8%
145	Muscular Dystrophy	5.8%
146	Congenital Hypothyroidism	5.7%
147	Porencephaly	5.6%
148	Foot Deformities	5.5%
149	Basal Cell Nevus Syndrome	5.5%
150	Felty Syndrome	5.5%
151	Limb Deformities, Congenital	5.4%
152	Genetic Diseases, Inborn	5.4%
153	Ectodermal Dysplasia	5.4%
154	Aplasia Cutis Congenita	5.4%
155	Prader-Willi Syndrome	5.4%
156	Cleft Palate	5.3%
157	Ainhum	5.3%
158	Dysostoses	5.3%
159	Fibrodysplasia Ossificans Progressiva	5.3%
160	Myoglobinuria	5.3%
161	Myositis Ossificans	5.3%
162	Spinal Stenosis	5.3%
163	Spondylosis	5.3%
164	Tenosynovitis	5.3%
165	Intervertebral Disc Degeneration	5.3%
166	Sacroiliitis	5.3%
167	Retrognathia	5.3%
168	Myotonic Dystrophy	5.2%
169	Cockayne Syndrome	5.2%
170	Eosinophilic Granuloma	5.2%
171	Myalgia	5.1%
172	Goldenhar Syndrome	4.9%
173	CHARGE Syndrome	4.9%
174	Rheumatoid Vasculitis	4.8%
175	Discitis	4.8%
176	Arthritis, Reactive	4.8%
177	Spondylarthropathies	4.8%
178	Fetal Diseases	4.6%
179	Anencephaly	4.5%
180	Arthritis, Infectious	4.5%
181	Abnormalities, Radiation-Induced	4.5%
182	Anterior Compartment Syndrome	4.4%
183	Osteomyelitis	4.4%
184	Osteoporosis	4.4%
185	Periostitis	4.4%
186	Enthesopathy	4.4%
187	Bone Demineralization, Pathologic	4.4%
188	Post-Traumatic Osteoporosis	4.4%
189	Arthritis, Experimental	4.4%
190	Abdominal Compartment Syndrome	4.4%
191	Alveolar Bone Loss	4.4%
192	Femur Head Necrosis	4.4%
193	Polymyositis	4.4%
194	Osteolysis	4.4%
195	Sicca Syndrome	4.4%
196	Sjogren's Syndrome	4.4%
197	Osteogenesis Imperfecta	4.4%
198	Xeroderma	4.3%
199	Mobius Syndrome	4.3%
200	Myotonia Congenita	4.2%
201	Tuberculosis, Spinal	4.2%
202	Prune Belly Syndrome	4.1%
203	Twins, Conjoined	4.1%
204	Waardenburg Syndrome	4.1%
205	Dural Arteriovenous Fistula	4%
206	Dextrocardia	4%
207	Hip Dislocation	3.9%
208	Shoulder Dislocation	3.9%
209	Hip Dysplasia	3.9%
210	Palatal Neoplasms	3.9%
211	Kartagener Syndrome	3.9%
212	Orbital Myositis	3.8%
213	Dupuytren Contracture	3.8%
214	Muscular Dystrophy, Duchenne	3.8%
215	Pyomyositis	3.8%
216	Acromegaly	3.8%
217	Joint Tuberculosis	3.8%
218	Tuberculosis, Osteoarticular	3.8%
219	Bone Tuberculosis	3.8%
220	Hypokalemic periodic paralysis	3.6%
221	Cystic Fibrosis	3.5%
222	Anophthalmos	3.5%
223	Anus, Imperforate	3.5%
224	Hydranencephaly	3.5%
225	Microphthalmos	3.5%
226	Neural Tube Defects	3.5%
227	Tethered Cord Syndrome	3.5%
228	Iniencephaly	3.5%
229	Craniorachischisis	3.5%
230	Exencephaly	3.5%
231	Septo-Optic Dysplasia	3.5%
232	Cortical Dysplasia	3.5%
233	Malformations of Cortical Development	3.5%
234	Anorectal Malformations	3.5%
235	Bloom Syndrome	3.4%
236	Polycystic Kidney Diseases	3.4%
237	Williams Syndrome	3.4%
238	Welander Distal Myopathy	3.4%
239	Pseudohypoparathyroidism	3.4%
240	Chondrodysplasia Punctata	3.4%
241	Enchondromatosis	3.4%
242	Lordosis	3.4%
243	Osteosclerosis	3.4%
244	Spondylolysis	3.4%
245	kyphosis	3.4%
246	Kashin-Beck Disease	3.4%
247	Rickets	3.3%
248	Shoulder Pain	3.3%
249	Scimitar Syndrome	3.2%
250	Lower Extremity Deformities, Congenital	3.2%
251	Retinal Dysplasia	3.2%
252	Aniridia	3.1%
253	Epidermolysis Bullosa	3.1%
254	Meconium Aspiration Syndrome	3.1%
255	Blepharophimosis	3%
256	Laryngostenosis	3%
257	Mouth Abnormalities	3%
258	Esophageal Atresia	3%
259	Intestinal Atresia	3%
260	Horseshoe Kidney	3%
261	Mitochondrial Encephalomyopathies	3%
262	Acrodermatitis	3%
263	Lymphangiectasis, Intestinal	3%
264	Gianotti-Crosti Syndrome	3%
265	Osteoporosis, Postmenopausal	2.8%
266	Smith-Lemli-Opitz Syndrome	2.8%
267	Alstrom Syndrome	2.8%
268	Ichthyosis, X-Linked	2.7%
269	Abdominal Cramps	2.7%
270	Amniotic Band Syndrome	2.7%
271	Asphyxia Neonatorum	2.7%
272	Infant, Premature, Diseases	2.7%
273	Infantile Colic	2.7%
274	Choanal Atresia	2.7%
275	Tracheobronchomegaly	2.7%
276	Laryngocele	2.7%
277	Choledochal Cyst	2.6%
278	Hermaphroditism	2.6%
279	Disorders of Sex Development	2.6%
280	Cryptorchidism	2.6%
281	Hypospadias	2.6%
282	Central Nervous System Cysts	2.6%
283	Dandy-Walker Syndrome	2.6%
284	POEMS Syndrome	2.6%
285	Pseudoxanthoma Elasticum	2.5%
286	Mastoiditis	2.4%
287	Petrositis	2.4%
288	Fragile X Syndrome	2.4%
289	Melorheostosis	2.4%
290	Osteopetrosis	2.4%
291	Spondylolisthesis	2.4%
292	Primary Ciliary Dyskinesia	2.3%
293	Xeroderma Pigmentosum	2.3%
294	Neoplastic Syndromes, Hereditary	2.3%
295	Bladder Exstrophy	2.3%
296	Epispadias	2.3%
297	Multicystic Dysplastic Kidney	2.3%
298	Anemia, Neonatal	2.2%
299	Pelger-Huet Anomaly	2.2%
300	Persistent Fetal Circulation Syndrome	2.2%
301	Werner Syndrome	2.2%
302	Myasthenic Syndromes, Congenital	2.2%
303	Umbilical hernia	2.2%
304	Dermatomyositis	2.2%
305	Osteomalacia	2.1%
306	Sjogren-Larsson Syndrome	2%
307	Zellweger Syndrome	2%
308	Neonatal Abstinence Syndrome	2%
309	Kallmann Syndrome	1.9%
310	Fetal Growth Retardation	1.9%
311	Fetal Hypoxia	1.9%
312	Congenital nystagmus	1.9%
313	Fetal Alcohol Spectrum Disorders	1.9%
314	Toxoplasmosis, Congenital	1.9%
315	Syphilis, Congenital	1.9%
316	Turner Syndrome	1.8%
317	Ectopia Cordis	1.8%
318	Meningomyelocele	1.8%
319	Spina Bifida	1.8%
320	Single umbilical artery	1.8%
321	Polycystic Kidney, Autosomal Dominant	1.8%
322	Anemia, Sickle Cell	1.7%
323	Thalassemia	1.7%
324	Autoimmune Lymphoproliferative Syndrome	1.7%
325	Congenital Hyperinsulinism	1.7%
326	Chorioamnionitis	1.7%
327	Angioedemas, Hereditary	1.7%
328	Charcot-Marie-Tooth Disease	1.6%
329	Albinism	1.6%
330	Nose Neoplasms	1.6%
331	Tuberous Sclerosis	1.6%
332	MELAS Syndrome	1.6%
333	Aortic coarctation	1.6%
334	Cor Triatriatum	1.6%
335	Coronary Vessel Anomalies	1.6%
336	Dental Enamel Hypoplasia	1.6%
337	Patent ductus arteriosus	1.6%
338	Ebstein Anomaly	1.6%
339	Heart Septal Defects	1.6%
340	Hypodontia	1.6%
341	Macrostomia	1.6%
342	Meningocele	1.6%
343	Microstomia	1.6%
344	Tetralogy of Fallot	1.6%
345	Transposition of Great Vessels	1.6%
346	Hypoplastic Left Heart Syndrome	1.6%
347	May-Thurner Syndrome	1.6%
348	Encephalocele	1.6%
349	Wolff-Parkinson-White Syndrome	1.5%
350	Renal Osteodystrophy	1.5%
351	Renal rickets	1.5%
352	Classical Lissencephalies and Subcortical Band Heterotopias	1.5%
353	Refsum Disease	1.4%
354	Wiskott-Aldrich Syndrome	1.4%
355	Long QT Syndrome	1.4%
356	Tricuspid Atresia	1.4%
357	Arrhythmogenic Right Ventricular Dysplasia	1.4%
358	Familial Mediterranean Fever	1.4%
359	Gonadal Dysgenesis	1.4%
360	Adrenogenital Syndrome	1.4%
361	Ovotesticular Disorders of Sex Development	1.4%
362	Radicular Cyst	1.3%
363	Ophthalmia Neonatorum	1.3%
364	Hyperkeratosis, Epidermolytic	1.3%
365	Klinefelter Syndrome	1.3%
366	Ataxia Telangiectasia	1.2%
367	Kearns-Sayre syndrome	1.2%
368	Paralysis, Obstetric	1.2%
369	Retinopathy of Prematurity	1.2%
370	Amino Acid Metabolism, Inborn Errors	1.1%
371	Carbohydrate Metabolism, Inborn Errors	1.1%
372	Metal Metabolism, Inborn Errors	1.1%
373	Progeria	1.1%
374	Lysosomal Storage Diseases	1.1%
375	Cytochrome-c Oxidase Deficiency	1.1%
376	Peroxisomal Disorders	1.1%
377	Bronchopulmonary Dysplasia	1.1%
378	Menkes Kinky Hair Syndrome	1%
379	Rett Syndrome	1%
380	Respiratory Distress Syndrome, Newborn	1%
381	Hyperandrogenism	1%
382	Dermal Sinus	1%
383	Spina Bifida Cystica	1%
384	Spina Bifida Occulta	1%
385	Lissencephaly	1%
386	Polymicrogyria	1%
387	Pachygyria	1%
388	Schizencephaly	1%
389	Periventricular Nodular Heterotopia	1%
390	Cutis Laxa	1%
391	Familial Hypophosphatemic Rickets	1%
392	Retinitis Pigmentosa	1%
393	Pigmentary retinopathy	1%
394	Porokeratosis	1%
395	Keratoderma, Palmoplantar	1%
396	Neuronal Ceroid-Lipofuscinoses	1%
397	Chronic granulomatous disease	1%
398	Amyloid Neuropathies, Familial	1%
399	Hepatolenticular Degeneration	0.9%
400	Mucopolysaccharidosis II	0.9%
401	Sickle Cell Trait	0.9%
402	Duane Retraction Syndrome	0.9%
403	Porphyrias, Hepatic	0.9%
404	Peutz-Jeghers Syndrome	0.9%
405	Thrombasthenia	0.9%
406	Antithrombin III Deficiency	0.9%
407	Protein C Deficiency	0.9%
408	Brain Diseases, Metabolic, Inborn	0.9%
409	Afibrinogenemia	0.9%
410	Dystonia Musculorum Deformans	0.9%
411	Factor VII Deficiency	0.9%
412	Factor X Deficiency	0.9%
413	Factor XII Deficiency	0.9%
414	Hemophilia A	0.9%
415	Leukomalacia, Periventricular	0.9%
416	Activated Protein C Resistance	0.9%
417	Factor II deficiency	0.9%
418	Factor VIII Deficiency	0.9%
419	Factor V deficiency	0.9%
420	Factor XI Deficiency	0.9%
421	Hypoprothrombinemias	0.9%
422	Aortopulmonary Septal Defect	0.9%
423	Double Outlet Right Ventricle	0.9%
424	Endocardial Cushion Defects	0.9%
425	Myocardial bridging	0.9%
426	Aorticopulmonary Septal Defect	0.9%
427	Fanconi Anemia	0.9%
428	Nesidioblastosis	0.9%
429	Lafora Disease	0.9%
430	Unverricht-Lundborg Syndrome	0.9%
431	Anemia, Diamond-Blackfan	0.9%
432	Adrenoleukodystrophy	0.8%
433	Hydrops Fetalis	0.8%
434	Multiple Endocrine Neoplasia	0.8%
435	Dermatitis, Atopic	0.8%
436	Romano-Ward Syndrome	0.7%
437	Canavan Disease	0.7%
438	Alexander Disease	0.7%
439	Acute Chest Syndrome	0.7%
440	Galactosemias	0.7%
441	Urea Cycle Disorders, Inborn	0.7%
442	Tyrosinemias	0.7%
443	Kernicterus	0.7%
444	Behcet Syndrome	0.7%
445	Optic Atrophy, Hereditary, Leber	0.7%
446	Hyperphosphaturia	0.7%
447	Fabry Disease	0.6%
448	Huntington Disease	0.6%
449	Arteriovenous fistula	0.6%
450	Alkaptonuria	0.6%
451	Glycogen Storage Disease	0.6%
452	Hypophosphatasia	0.6%
453	Propionic acidemia	0.6%
454	Dihydropyrimidine Dehydrogenase Deficiency	0.6%
455	Cystinosis	0.6%
456	Denys-Drash Syndrome	0.6%
457	Nephroblastoma	0.6%
458	Adenomatous Polyposis Coli	0.5%
459	Hyaline Membrane Disease	0.5%
460	Hypolipoproteinemias	0.5%
461	Papillon-Lefevre Disease	0.5%
462	Hyperlipidemia, Familial Combined	0.5%
463	Homocystinuria	0.5%
464	Hyperlipoproteinemia Type III	0.5%
465	Truncus Arteriosus, Persistent	0.5%
466	Leigh Disease	0.5%
467	Glycogen storage disease type II	0.5%
468	Lactose Intolerance	0.5%
469	Variegate Porphyria	0.5%
470	Acute intermittent porphyria	0.5%
471	Porphyria Cutanea Tarda	0.5%
472	Hyperhomocysteinemia	0.5%
473	Renal Aminoacidurias	0.4%
474	Fanconi Syndrome	0.4%
475	Pseudohypoaldosteronism	0.4%
476	Liddle Syndrome	0.4%
477	Hyperlipoproteinemia Type IV	0.4%
478	Hyperlipoproteinemia Type V	0.4%
479	Mucopolysaccharidosis III	0.4%
480	Multiple Endocrine Neoplasia Type 1	0.4%
481	Friedreich Ataxia	0.4%
482	Renal tubular acidosis	0.4%
483	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.4%
484	Glycogen Storage Disease Type I	0.3%
485	Glycogen Storage Disease Type V	0.3%
486	Glycosuria, Renal	0.3%
487	Hypoalphalipoproteinemias	0.3%
488	Gaucher Disease	0.3%
489	Cystinuria	0.2%
490	Niemann-Pick Disease, Type C	0.2%
491	Tay-Sachs Disease	0.1%

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