MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypoxia-Ischemia, Brain

(UMLS:C0752308)

Definition:: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
UMLS ID:: C0752308
MeSH ID:: D020925

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.300.150.716|C10.228.140.624.500

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.253.092.716

Synonym(s)

Hypoxia-Ischemia, Brain

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cocaine	8515225 15228774	CTD
2	Dexamethasone	9042522	CTD
3	Digitoxin	14574425	CTD
4	Fluoxetine	16887358	CTD
5	Lithium Chloride	21364661	CTD
6	Methamphetamine	24412707	CTD
7	Ouabain	1528398	CTD
8	caffeic acid phenethyl ester	15469948	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Brain Infarction	50.8%
2	Vertebrobasilar Insufficiency	45.8%
3	Basilar Artery Stenosis	45.8%
4	Vertebral Artery Stenosis	45.8%
5	Transient Cerebral Ischemia	45.8%
6	Basal Ganglia Cerebrovascular Disease	44.2%
7	Vascular Headaches	40.3%
8	Dementia, Vascular	38.7%
9	Cerebral Infarction	38.6%
10	Brain Stem Infarctions	38.6%
11	Leukomalacia, Periventricular	38.1%
12	Carotid Artery Diseases	37.2%
13	Cerebrovascular accident	37.2%
14	Vasospasm, Intracranial	37.2%
15	Intracranial Arterial Diseases	37.2%
16	Infarction, Middle Cerebral Artery	36.1%
17	Infarction, Anterior Cerebral Artery	36.1%
18	Infarction, Posterior Cerebral Artery	36.1%
19	Subclavian Steal Syndrome	34.8%
20	Intracranial Embolism and Thrombosis	34.2%
21	Lateral Medullary Syndrome	32.6%
22	Subdural Effusion	31.7%
23	Moyamoya Disease	31.7%
24	Meningoencephalitis	31.6%
25	Vasculitis, Central Nervous System	31.3%
26	Akinetic Mutism	31.2%
27	Basal Ganglia Diseases	31.2%
28	Brain Damage, Chronic	31.2%
29	Cerebellar Diseases	31.2%
30	Encephalitis	31.2%
31	Encephalomalacia	31.2%
32	Epilepsy	31.2%
33	Hydrocephalus	31.2%
34	Congenital Hydrocephalus	31.2%
35	Hypothalamic Diseases	31.2%
36	Thalamic Diseases	31.2%
37	Intracranial Hypertension	31.2%
38	Aura	31.2%
39	Leukoencephalopathy	31.2%
40	Neuroaxonal Dystrophies	31.2%
41	Headache Disorders	31.2%
42	Intracranial Hypotension	31.2%
43	Brain Edema	31.2%
44	Aqueductal Stenosis	31.2%
45	Basal Ganglia Hemorrhage	31%
46	Carotid Artery Injuries	30.3%
47	Encephalomyelitis	29.7%
48	Dandy-Walker Syndrome	27.4%
49	Posterior Leukoencephalopathy Syndrome	26.9%
50	Posterior reversible encephalopathy syndrome	26.9%
51	Carotid Artery Thrombosis	26.5%
52	Parkinsonian Disorders	26.5%
53	Pituitary Apoplexy	26.5%
54	Multiple System Atrophy	26.4%
55	Pneumocephalus	26.3%
56	Carotid Stenosis	26.1%
57	Intracranial Aneurysm	26.1%
58	Brain Abscess	25.9%
59	Brain Diseases, Metabolic	25.4%
60	Dementia	25.4%
61	Cerebral Arterial Diseases	25.3%
62	Intracranial Hemorrhage, Hypertensive	25.3%
63	Lewy Body Disease	25.3%
64	Subarachnoid Hemorrhage, Traumatic	25.1%
65	Putaminal Hemorrhage	24.8%
66	Intracranial Arteriosclerosis	24.3%
67	Cerebral Atherosclerosis	24.3%
68	Cerebral Arteriosclerosis	24.3%
69	Epilepsy, Post-Traumatic	24.1%
70	Brain Injuries	24%
71	Brain Neoplasms	23.8%
72	Cerebral Thrombosis	23.5%
73	Intracranial Embolism	23.5%
74	Intracranial Thrombosis	23.5%
75	Meningitis	23.5%
76	Movement Disorders	23.5%
77	Pachymeningitis	23.5%
78	Spinal Cord Diseases	23.5%
79	Carotid Artery, Internal, Dissection	22.5%
80	Meige Syndrome	22.5%
81	Cerebral Ventriculitis	22.5%
82	Lupus Vasculitis, Central Nervous System	22.4%
83	Myoclonic Epilepsy	22.4%
84	Epilepsy, Temporal Lobe	22.4%
85	Epilepsy, Rolandic	22.4%
86	Benign Rolandic Epilepsy	22.4%
87	Marchiafava-Bignami Disease	22.3%
88	Ocular Motility Disorders	21.9%
89	Cyclophoria	21.9%
90	Brain Death	21.9%
91	Myelitis	21.5%
92	Subarachnoid Hemorrhage	21.1%
93	Cerebral Hemorrhage	21.1%
94	Spinal Cord Vascular Diseases	20.8%
95	Vertebral Artery Dissection	20.6%
96	Parkinson Disease	20.4%
97	Cerebellar Neoplasms	20.3%
98	Huntington Disease	20.2%
99	Epidural Abscess	20.2%
100	Brain Hemorrhage, Traumatic	19.9%
101	Cerebral Palsy	19.7%
102	Epilepsies, Partial	19.7%
103	Epilepsy, Generalized	19.7%
104	Pseudotumor Cerebri	19.7%
105	Hypertensive Encephalopathy	19.7%
106	Simple Partial Seizures	19.7%
107	Epilepsy, Reflex	19.7%
108	Headache Disorders, Primary	19.7%
109	Headache Disorders, Secondary	19.7%
110	Medication overuse headache	19.7%
111	Amblyopia	19.6%
112	Central Nervous System Infection	19.6%
113	Creutzfeldt-Jakob disease	18.9%
114	Dystonia Musculorum Deformans	18.8%
115	Neuroleptic Malignant Syndrome	18.6%
116	Myelinolysis, Central Pontine	18.6%
117	Shy-Drager Syndrome	18.6%
118	Giant Cell Arteritis	18.4%
119	Temporal Arteritis	18.4%
120	Sinus Thrombosis, Intracranial	18.2%
121	Juvenile Myoclonic Epilepsy	17.8%
122	Myoclonic Epilepsies, Progressive	17.8%
123	Progressive supranuclear palsy	17.4%
124	Leukoencephalopathy, Progressive Multifocal	17.3%
125	Prion Diseases	17.2%
126	Striatonigral Degeneration	17.1%
127	Stiff-Person Syndrome	16.9%
128	Amnesia, Transient Global	16.5%
129	Pituitary Diseases	16.5%
130	Limbic Encephalitis	16.4%
131	Presenile dementia	16.3%
132	Senile dementia	16.3%
133	Cerebral Amyloid Angiopathy	16.2%
134	MELAS Syndrome	15.9%
135	Kluver-Bucy Syndrome	15.9%
136	Cavernous Sinus Thrombosis	15.5%
137	Sagittal Sinus Thrombosis	15.5%
138	Pituitary Adenoma	15.1%
139	Pituitary Neoplasms	15.1%
140	Brain Injuries, Diffuse	15%
141	Traumatic Brain Injury	15%
142	Spinal Muscular Atrophy	15%
143	Progressive Muscular Atrophy	15%
144	Cerebellar Ataxia	15%
145	Supratentorial Neoplasms	15%
146	Hepatolenticular Degeneration	14.9%
147	Cranial nerve diseases	14.9%
148	Demyelinating Diseases	14.9%
149	Demyelination	14.9%
150	Neuromuscular Diseases	14.9%
151	Chronobiology Disorders	14.9%
152	Spinal Cord Injuries	14.8%
153	Subacute Combined Degeneration	14.7%
154	Meningitis, Bacterial	14.6%
155	Meningitis, Fungal	14.6%
156	Leukoencephalitis, Acute Hemorrhagic	14.5%
157	MPTP Poisoning	14.4%
158	Persistent Vegetative State	14.4%
159	Asterixis	14.3%
160	Ballismus	14.3%
161	Poliomyelitis	14.2%
162	Anoxic Encephalopathy	14.2%
163	Brain Hypoxia	14.2%
164	Post-Traumatic Headache	14%
165	Tension Headache	14%
166	Epilepsy, Complex Partial	14%
167	Migraine Disorders	14%
168	Abdominal Migraine	14%
169	Status Migrainosus	14%
170	Cervicogenic Headache	14%
171	Paraneoplastic Cerebellar Degeneration	13.9%
172	Cerebrovascular Disorders	13.9%
173	Cerebrovascular Insufficiency	13.9%
174	Lafora Disease	13.8%
175	Unverricht-Lundborg Syndrome	13.8%
176	Toxoplasmosis, Cerebral	13.7%
177	Amyotrophic Lateral Sclerosis	13.5%
178	Myocardial Ischemia	13.4%
179	Arachnoiditis	13.4%
180	Aseptic Meningitis	13.4%
181	Syringomyelia	13.4%
182	Essential Tremor	13.4%
183	Familial Tremor	13.4%
184	Pneumorrhachis	13.4%
185	Writer's Cramp	13.4%
186	Reye Syndrome	13.3%
187	Hepatic Encephalopathy	13.2%
188	Encephalomyelitis, Acute Disseminated	13.2%
189	Ophthalmoplegic Migraine	13.1%
190	Chronic Fatigue Syndrome	12.8%
191	Motor Neuron Disease	12.7%
192	Friedreich Ataxia	12.7%
193	Spinal Cord Ischemia	12.6%
194	Miller Fisher Syndrome	12.5%
195	Canavan Disease	12.5%
196	Alexander Disease	12.5%
197	Trauma, Nervous System	12.4%
198	Aneurysm	12.3%
199	Angiomatosis	12.3%
200	Aortic Diseases	12.3%
201	Arterial Occlusive Diseases	12.3%
202	Hyperemia	12.3%
203	Hypotension	12.3%
204	Superior Vena Cava Syndrome	12.3%
205	Telangiectasis	12.3%
206	Vasculitis	12.3%
207	Venous Insufficiency	12.3%
208	Peripheral Vascular Diseases	12.3%
209	Embolism and Thrombosis	12.3%
210	Angiodysplasia	12.3%
211	Capillary Leak Syndrome	12.3%
212	Prehypertension	12.3%
213	Thoracic Outlet Syndrome	12.1%
214	Hematoma, Subdural	12.1%
215	Hematoma, Epidural, Cranial	12.1%
216	Nervous System Neoplasms	12%
217	Neurologic Manifestations	12%
218	Neurotoxicity Syndromes	12%
219	Spinal Cord Neoplasms	11.9%
220	Aortic Aneurysm	11.7%
221	Aortitis	11.7%
222	Leriche Syndrome	11.7%
223	Periphlebitis	11.7%
224	Phlebitis	11.7%
225	Thromboangiitis Obliterans	11.7%
226	Hand-Arm Vibration Syndrome	11.7%
227	Ataxia Telangiectasia	11.5%
228	Empty Sella Syndrome	11.4%
229	Hyperpituitarism	11.4%
230	Hypopituitarism	11.4%
231	Hypophysitis	11.4%
232	Brain Diseases, Metabolic, Inborn	11.4%
233	Optic Neuropathy, Ischemic	11.4%
234	Anterior Ischemic Optic Neuropathy	11.4%
235	Mitochondrial Encephalomyopathies	11.4%
236	Hypoxia-Ischemia, Brain	11.2%
237	Cluster Headache	11.2%
238	Migraine with Aura	11.2%
239	Familial Hemiplegic Migraine	11.2%
240	Chronic Paroxysmal Hemicrania	11.2%
241	SUNCT Syndrome	11.2%
242	Paroxysmal Hemicrania	11.2%
243	Myelitis, Transverse	11.1%
244	Restless Legs Syndrome	11.1%
245	Fabry Disease	11%
246	Central Nervous System Fungal Infections	10.9%
247	Conus Medullaris Syndrome	10.9%
248	Akathisia, Drug-Induced	10.8%
249	Retinal Vein Occlusion	10.8%
250	Polyradiculoneuropathy	10.7%
251	Polyradiculoneuritis	10.7%
252	Diffuse Axonal Injury	10.6%
253	Brain Stem Neoplasms	10.6%
254	Vascular System Injuries	10.3%
255	Opsoclonus-Myoclonus Syndrome	10.2%
256	Sleep Wake Disorders	10.2%
257	Tuberculosis, Meningeal	10.2%
258	Sturge-Weber Syndrome	10.1%
259	Auditory Perceptual Disorders	10.1%
260	Hematoma, Subdural, Intracranial	10.1%
261	Hematoma, Subdural, Chronic	10.1%
262	Hematoma, Subdural, Acute	10.1%
263	Compartment syndromes	10%
264	Hepatic Veno-Occlusive Disease	10%
265	Peliosis Hepatis	10%
266	Varicocele	10%
267	Wernicke Encephalopathy	9.9%
268	AIDS Dementia Complex	9.9%
269	Diabetic Angiopathies	9.9%
270	Reperfusion Injury	9.9%
271	Splenic Infarction	9.9%
272	Autonomic Dysreflexia	9.9%
273	Vascular Neoplasms	9.9%
274	Complex Regional Pain Syndromes	9.9%
275	Vasoplegia	9.9%
276	Hemorrhoids	9.8%
277	Myocardial Reperfusion Injury	9.8%
278	Malignant Atrophic Papulosis	9.8%
279	Shwartzman Phenomenon	9.8%
280	Postphlebitic Syndrome	9.7%
281	Adrenoleukodystrophy	9.6%
282	Frontotemporal dementia	9.6%
283	Subacute Sclerosing Panencephalitis	9.5%
284	Dyskinesia, Drug-Induced	9.4%
285	Central Nervous System Bacterial Infections	9.2%
286	Brain Contusion	9.2%
287	Coronary Aneurysm	9.2%
288	Brain Ischemia	9.1%
289	Hyperprolactinemia	9%
290	Kernicterus	9%
291	Pick Disease of the Brain	8.9%
292	Thrombophlebitis	8.8%
293	Scrapie	8.8%
294	Central Cord Syndrome	8.8%
295	Anterior Spinal Artery Syndrome	8.7%
296	Chorea	8.6%
297	Choroid Plexus Papilloma	8.5%
298	Brain Concussion	8.4%
299	Aortic Rupture	8.4%
300	Peripheral Nerve Injuries	8.4%
301	Mesenteric vascular insufficiency	8.4%
302	Meningitis, Cryptococcal	8.3%
303	Myasthenia Gravis	8.3%
304	Meningitis, Listeria	8.3%
305	Meningitis, Haemophilus	8.2%
306	Meningitis, Pneumococcal	8.2%
307	Blue Toe Syndrome	8.2%
308	Angioedema	8.2%
309	Colitis, Ischemic	8.2%
310	Hypotension, Orthostatic	8.1%
311	Post-Exercise Hypotension	8.1%
312	Arteriovenous fistula	7.9%
313	Dysautonomia	7.8%
314	Vagus Nerve Disorder	7.8%
315	Glossopharyngeal Neuralgia	7.8%
316	Abducens Nerve Diseases	7.8%
317	Heavy Metal Poisoning, Nervous System	7.8%
318	Neuromuscular Junction Diseases	7.8%
319	Tauopathies	7.8%
320	Trochlear Nerve Diseases	7.8%
321	Peripheral Nervous System Diseases	7.8%
322	Coronary heart disease	7.8%
323	Myocardial Infarction	7.8%
324	Acute Coronary Syndrome	7.8%
325	Guillain-Barre Syndrome	7.7%
326	Aortic Aneurysm, Abdominal	7.7%
327	Aortic Aneurysm, Thoracic	7.7%
328	Heart Diseases	7.7%
329	Acromegaly	7.6%
330	Lambert-Eaton Myasthenic Syndrome	7.5%
331	Coronary Thrombosis	7.5%
332	Coronary Artery Disease	7.5%
333	Alice in Wonderland Syndrome	7.5%
334	Torticollis	7.5%
335	Sleep Disorders, Circadian Rhythm	7.3%
336	Aneurysm, Dissecting	7.3%
337	Arteriosclerosis	7.3%
338	Arteritis	7.3%
339	Embolism	7.3%
340	Erythromelalgia	7.3%
341	Fibromuscular Dysplasia	7.3%
342	Malignant Hypertension	7.3%
343	Raynaud Disease	7.3%
344	Thromboembolism	7.3%
345	Thrombosis	7.3%
346	Essential Hypertension	7.3%
347	Aneurysm, Ruptured	7.3%
348	Iliac Aneurysm	7.3%
349	Pulmonary artery stenosis	7.3%
350	White Coat Hypertension	7.3%
351	Systemic Vasculitis	7.3%
352	Embolus	7.3%
353	Progressive bulbar palsy	7.2%
354	Bulbar palsy	7.2%
355	West Nile Fever	7.1%
356	Botulism	7.1%
357	Central Nervous System Cysts	7.1%
358	Causalgia	6.7%
359	Olfactory Nerve Injuries	6.7%
360	Tuberculosis, Central Nervous System	6.7%
361	Scimitar Syndrome	6.7%
362	Refsum Disease	6.7%
363	Kounis Syndrome	6.6%
364	Myopathy	6.5%
365	Optic Neuropathy	6.5%
366	May-Thurner Syndrome	6.5%
367	Angina Pectoris	6.5%
368	Polyarteritis Nodosa	6.5%
369	Takayasu Arteritis	6.5%
370	Facial Nerve Diseases	6.4%
371	Craniocerebral Trauma	6.4%
372	Parasomnia	6.4%
373	Dyssomnias	6.4%
374	Neuromyelitis Optica	6.3%
375	Vestibulocochlear Nerve Diseases	6.3%
376	Decerebrate State	6.3%
377	Hemiparesis	6.3%
378	Hydranencephaly	6.3%
379	Meningism	6.3%
380	Neural Tube Defects	6.3%
381	Paresis	6.3%
382	Seizures	6.3%
383	Sensation Disorders	6.3%
384	Tethered Cord Syndrome	6.3%
385	Central Nervous System Neoplasms	6.3%
386	Complex partial seizures	6.3%
387	Iniencephaly	6.3%
388	Craniorachischisis	6.3%
389	Exencephaly	6.3%
390	Monoparesis	6.3%
391	Septo-Optic Dysplasia	6.3%
392	Cortical Dysplasia	6.3%
393	Neurogenic Inflammation	6.3%
394	Gait Disorders, Neurologic	6.3%
395	Neuromuscular Manifestations	6.3%
396	Malformations of Cortical Development	6.3%
397	Galactosemias	6.2%
398	Urea Cycle Disorders, Inborn	6.2%
399	Tyrosinemias	6.2%
400	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.2%
401	Sweating, Gustatory	6.2%
402	Auriculotemporal Syndrome	6.2%
403	Pregnancy Complications, Cardiovascular	6.2%
404	Cardiovascular Abnormalities	6.2%
405	Horner Syndrome	6.1%
406	Embolism, Amniotic Fluid	6%
407	Multiple Sclerosis	6%
408	Retinal Artery Occlusion	5.9%
409	Retinal Vasculitis	5.9%
410	Hypertensive Retinopathy	5.9%
411	Facial Nerve Injuries	5.9%
412	Dural Arteriovenous Fistula	5.9%
413	Tardive Dyskinesia	5.9%
414	Anterior Compartment Syndrome	5.9%
415	Vasculitis, Leukocytoclastic, Cutaneous	5.9%
416	Gastric Antral Vascular Ectasia	5.9%
417	Abdominal Compartment Syndrome	5.9%
418	Reflex Sympathetic Dystrophy	5.8%
419	Varicose Ulcer	5.8%
420	Nocturnal Myoclonus Syndrome	5.8%
421	Primary Graft Dysfunction	5.8%
422	Neuroaspergillosis	5.7%
423	Homocystinuria	5.7%
424	Prolactinoma	5.7%
425	Growth Hormone-Secreting Pituitary Adenoma	5.7%
426	Leigh Disease	5.6%
427	Nelson Syndrome	5.6%
428	Pupil Disorders	5.4%
429	Neurobehavioral Manifestations	5.4%
430	CREST Syndrome	5.4%
431	Jet Lag Syndrome	5.3%
432	Paraneoplastic Encephalomyelitis	5.3%
433	Uveomeningoencephalitic Syndrome	5.2%
434	Myasthenia Gravis, Autoimmune, Experimental	5.2%
435	Vertigo	5.2%
436	Alcohol-Induced Disorders, Nervous System	5.2%
437	Ophthalmoplegia	5.2%
438	External Ophthalmoplegia	5.2%
439	Tuberous Sclerosis	5.2%
440	Coronary Occlusion	5.1%
441	Microvascular Angina	5.1%
442	Coronary Stenosis	5.1%
443	ST segment elevation myocardial infarction	5.1%
444	Pseudorabies	5.1%
445	Mesenteric Vascular Occlusion	5%
446	Mucocutaneous Lymph Node Syndrome	5%
447	Menkes Kinky Hair Syndrome	5%
448	Diabetic Retinopathy	4.9%
449	Livedo Reticularis	4.9%
450	Renal hypertension	4.9%
451	Renal Artery Obstruction	4.9%
452	Renal Artery Stenosis	4.9%
453	Hemangioma, Cavernous	4.9%
454	Acrodynia	4.8%
455	Scurvy	4.8%
456	Neurosyphilis	4.8%
457	Arteriosclerosis Obliterans	4.8%
458	Atherosclerosis	4.8%
459	Air Embolism	4.8%
460	Endarteritis	4.8%
461	Venous Thrombosis	4.8%
462	Deep Vein Thrombosis	4.8%
463	Venous Thromboembolism	4.8%
464	Charcot-Marie-Tooth Disease	4.6%
465	Lemierre Syndrome	4.6%
466	Voice Disorders	4.6%
467	Voice Disturbance	4.6%
468	Vocal Cord Paralysis	4.6%
469	Brachial Plexus Neuritis	4.5%
470	Neuralgic Amyotrophy	4.5%
471	Smith-Magenis syndrome	4.5%
472	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.5%
473	Neuritis	4.5%
474	Polyneuritis	4.5%
475	Radiculitis	4.5%
476	Polyneuropathy	4.5%
477	Mononeuritis	4.5%
478	Mononeuropathies	4.5%
479	Brachial Plexus Neuropathies	4.5%
480	Radiculopathy	4.5%
481	Mononeuropathy Multiplex	4.5%
482	Nerve Root Compression	4.5%
483	Zellweger Syndrome	4.4%
484	Shock, Cardiogenic	4.3%
485	Angina, Unstable	4.3%
486	Lyme Neuroborreliosis	4.2%
487	Ischemic contracture	4.2%
488	Angioedemas, Hereditary	4.2%
489	Myotonia Congenita	4.2%
490	Tricuspid Atresia	4.2%
491	Arrhythmogenic Right Ventricular Dysplasia	4.2%
492	Cryoglobulinemia	4.2%
493	Cerebrospinal Fluid Otorrhea	4.2%
494	Cerebrospinal Fluid Rhinorrhea	4.2%
495	Neuritis, Autoimmune, Experimental	4.2%
496	Diabetic Foot	4.1%
497	Gait Ataxia	4.1%
498	Cardiac Tamponade	4.1%
499	Endocarditis	4.1%
500	Cardiac Arrest	4.1%
501	Heart failure	4.1%
502	Pericardial effusion	4.1%
503	Pericarditis	4.1%
504	Pneumopericardium	4.1%
505	Cor pulmonale	4.1%
506	Ventricular Outflow Obstruction	4.1%
507	Ventricular Dysfunction	4.1%
508	Cardiomyopathies	4.1%
509	Pleuropericarditis	4.1%
510	Toxoplasmosis, Congenital	4.1%
511	Malaria, Cerebral	4.1%
512	Glycogen storage disease type II	4%
513	Coma, Post-Head Injury	4%
514	Neurocysticercosis	4%
515	Alcohol Withdrawal Seizures	4%
516	Intermittent Claudication	3.9%
517	Pulmonary Embolism	3.9%
518	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.9%
519	Aortic Valve Stenosis	3.9%
520	Cardiomyopathy, Dilated	3.9%
521	Pulmonary Valve Stenosis	3.9%
522	Reflex, Abnormal	3.9%
523	Hyporeflexia	3.9%
524	Hyperreflexia	3.9%
525	No-Reflow Phenomenon	3.9%
526	Tarsal Tunnel Syndrome	3.8%
527	Cauda Equina Syndrome	3.8%
528	Coronary Restenosis	3.8%
529	Bacterial Endocarditis	3.8%
530	Myotonic Dystrophy	3.7%
531	Multiple Sclerosis, Chronic Progressive	3.7%
532	Multiple Sclerosis, Relapsing-Remitting	3.7%
533	Akathisia	3.6%
534	Restlessness	3.6%
535	Psychomotor Agitation	3.6%
536	Purpura, Hyperglobulinemic	3.6%
537	Myositis	3.6%
538	Optic Atrophy	3.6%
539	Optic Neuritis	3.6%
540	Papilledema	3.6%
541	Strabismus	3.6%
542	Tolosa-Hunt Syndrome	3.6%
543	Isaacs syndrome	3.6%
544	Arsenic Poisoning	3.6%
545	Myotonic Disorders	3.6%
546	Myasthenic Syndromes, Congenital	3.6%
547	Waterhouse-Friderichsen Syndrome	3.6%
548	Diabetic Neuropathies	3.6%
549	Facial Injuries	3.6%
550	Facial Neuralgia	3.6%
551	Diabetic Amyotrophy	3.6%
552	Diabetic Autonomic Neuropathy	3.6%
553	Sleep Talking	3.6%
554	Manganese Poisoning	3.6%
555	Sleep Disorders, Intrinsic	3.6%
556	Orthostatic intolerance	3.6%
557	Anosmia	3.6%
558	Ataxia	3.6%
559	Athetosis	3.6%
560	Catalepsy	3.6%
561	Dystonia	3.6%
562	Hemiplegia	3.6%
563	Locked-In Syndrome	3.6%
564	Meningeal Neoplasms	3.6%
565	Meningomyelocele	3.6%
566	Muscle Hypertonia	3.6%
567	Muscle hypotonia	3.6%
568	Myoclonus	3.6%
569	Myotonia	3.6%
570	Neuralgia	3.6%
571	Paraplegia	3.6%
572	Pseudobulbar Palsy	3.6%
573	Quadriplegia	3.6%
574	Spasm	3.6%
575	Spastic Paraplegia	3.6%
576	Status Epilepticus	3.6%
577	Taste Disorders	3.6%
578	Tremor	3.6%
579	Spina Bifida	3.6%
580	Monoplegia	3.6%
581	Hypokinesia	3.6%
582	Paraparesis	3.6%
583	Bradykinesia	3.6%
584	Waxy flexibility	3.6%
585	Action Tremor	3.6%
586	Resting Tremor	3.6%
587	Dysosmia	3.6%
588	Quadriparesis	3.6%
589	Mercury Poisoning, Nervous System	3.6%
590	Olfaction Disorders	3.6%
591	Myokymia	3.6%
592	Lead Poisoning, Nervous System	3.6%
593	Vestibular Neuronitis	3.6%
594	Somatosensory Disorders	3.6%
595	Neuropathic pain	3.6%
596	Hyperkinesia	3.6%
597	Intention tremor	3.6%
598	Cardiac Output, High	3.3%
599	Myocardial Stunning	3.3%
600	Low Cardiac Output Syndrome	3.3%
601	Cardiomegaly	3.3%
602	Postpericardiotomy Syndrome	3.3%
603	Cardiac Hypertrophy	3.3%
604	Behcet Syndrome	3.3%
605	Heart Block	3.3%
606	Tachycardia	3.3%
607	Tachyarrhythmia	3.3%
608	Rheumatic Heart Disease	3.3%
609	Waldenstrom Macroglobulinemia	3.3%
610	Multiple Myeloma	3.3%
611	Aortic coarctation	3.3%
612	Cor Triatriatum	3.3%
613	Coronary Vessel Anomalies	3.3%
614	Patent ductus arteriosus	3.3%
615	Ebstein Anomaly	3.3%
616	Heart Septal Defects	3.3%
617	Tetralogy of Fallot	3.3%
618	Transposition of Great Vessels	3.3%
619	Hypoplastic Left Heart Syndrome	3.3%
620	Gaucher Disease	3.2%
621	Carpal Tunnel Syndrome	3.2%
622	Gait Apraxia	3.2%
623	Hypertension, Renovascular	3.2%
624	neurofibroma	3.2%
625	Sciatica	3.2%
626	Optic Nerve Glioma	3.2%
627	Hereditary Angioedema Type III	3.2%
628	Hereditary Angioedema Types I and II	3.2%
629	Angina Pectoris, Variant	3.2%
630	Alstrom Syndrome	3.1%
631	Vision Disorders	3.1%
632	Metamorphopsia	3.1%
633	Visual Impairment	3.1%
634	Fibromyalgia	3.1%
635	Medial Tibial Stress Syndrome	3.1%
636	Facial Hemiatrophy	3%
637	Melkersson-Rosenthal Syndrome	3%
638	Mitochondrial Myopathies	3%
639	Anisocoria	3%
640	Confusion	3%
641	Facial paralysis	3%
642	Lethargy	3%
643	Memory Disorders	3%
644	Muscle Cramp	3%
645	Perceptual Disorders	3%
646	Psychomotor Disorders	3%
647	Tonic Pupil	3%
648	Eosinophilia-Myalgia Syndrome	3%
649	Anhedonia	3%
650	Disorientation	3%
651	Facial Paresis	3%
652	Memory Loss	3%
653	Hemisensory Neglect	3%
654	Dysacusis	3%
655	Sleep Bruxism	3%
656	Anencephaly	3%
657	Meningocele	3%
658	Muscular Atrophy	3%
659	Respiratory Paralysis	3%
660	Encephalocele	3%
661	Pseudoxanthoma Elasticum	3%
662	Acoustic Neuroma	3%
663	Tetany	3%
664	Hepatic Vein Thrombosis	2.9%
665	Budd-Chiari Syndrome	2.9%
666	Amyloid Neuropathies, Familial	2.9%
667	Hypertrophic Cardiomyopathy	2.9%
668	Pulmonary Infarction	2.9%
669	Hypertrophic obstructive cardiomyopathy	2.9%
670	Tay-Sachs Disease	2.9%
671	Sciatic Neuropathy	2.8%
672	Ulnar Neuropathies	2.8%
673	Lesion of Sciatic Nerve	2.8%
674	Ulnar Neuritis	2.8%
675	Radial nerve compression	2.8%
676	Radial Tunnel Syndrome	2.8%
677	Peroneal Neuropathies	2.8%
678	Radial Neuropathy	2.8%
679	Median Neuropathy	2.8%
680	Sciatic Nerve Palsy	2.8%
681	Femoral Neuropathy	2.8%
682	Tibial Neuropathy	2.8%
683	Ulnar Nerve Palsy	2.8%
684	Postural Orthostatic Tachycardia Syndrome	2.8%
685	Radial nerve palsy	2.8%
686	Dextrocardia	2.8%
687	Long QT Syndrome	2.8%
688	Niemann-Pick Disease, Type C	2.8%
689	Cubital Tunnel Syndrome	2.7%
690	Duane Retraction Syndrome	2.6%
691	Consciousness Disorders	2.6%
692	Mental Retardation	2.6%
693	Muscle Weakness	2.6%
694	Depressed Level of Consciousness	2.6%
695	Mental deficiency	2.6%
696	Intellectual Disability	2.6%
697	Mobius Syndrome	2.6%
698	Bell Palsy	2.6%
699	Kearns-Sayre syndrome	2.6%
700	Catatonia	2.6%
701	Herpes Zoster Oticus	2.6%
702	Familial Periodic Paralysis	2.6%
703	Supravalvular aortic stenosis	2.6%
704	Lown-Ganong-Levine Syndrome	2.6%
705	Aphonia	2.6%
706	Sleep Deprivation	2.6%
707	Dysphonia	2.6%
708	Rheumatoid Vasculitis	2.4%
709	Granulomatosis with polyangiitis	2.4%
710	Aortic Valve Insufficiency	2.4%
711	Restrictive cardiomyopathy	2.4%
712	Endocardial Fibroelastosis	2.4%
713	Heart Rupture, Post-Infarction	2.4%
714	Mitral Valve Insufficiency	2.4%
715	Mitral Valve Stenosis	2.4%
716	Myocarditis	2.4%
717	Pericarditis, Constrictive	2.4%
718	Pulmonary Valve Insufficiency	2.4%
719	Tricuspid Valve Insufficiency	2.4%
720	Tricuspid Valve Stenosis	2.4%
721	Ventricular Dysfunction, Left	2.4%
722	Right Ventricular Dysfunction	2.4%
723	Endomyocardial Fibrosis	2.4%
724	Carditis	2.4%
725	Heart Failure, Systolic	2.4%
726	Heart Failure, Diastolic	2.4%
727	Sick Sinus Syndrome	2.4%
728	Classical Lissencephalies and Subcortical Band Heterotopias	2.4%
729	Williams Syndrome	2.3%
730	Carcinoid Heart Disease	2.3%
731	Esotropia	2.3%
732	Exotropia	2.3%
733	Sleep Apnea Syndromes	2.3%
734	Polymyositis	2.3%
735	Disorders of Excessive Somnolence	2.3%
736	Sleep Initiation and Maintenance Disorders	2.3%
737	Night Terrors	2.3%
738	Somnambulism	2.3%
739	Trigeminal Nerve Disorder	2.3%
740	Transient Insomnia	2.3%
741	Sleep Paralysis	2.3%
742	Chronic Insomnia	2.3%
743	REM Sleep Behavior Disorder	2.3%
744	Hypersomnia	2.3%
745	Myalgia	2.2%
746	Dermal Sinus	2.2%
747	Dysgeusia	2.2%
748	Formication	2.2%
749	Hyperalgesia	2.2%
750	Hyperesthesia	2.2%
751	Hypesthesia	2.2%
752	Language Disorders	2.2%
753	Numbness	2.2%
754	Paresthesia	2.2%
755	Paraparesis, Spastic	2.2%
756	Spina Bifida Cystica	2.2%
757	Trismus	2.2%
758	Spina Bifida Occulta	2.2%
759	Epilepsia Partialis Continua	2.2%
760	Hypogeusia	2.2%
761	Meningeal Carcinomatosis	2.2%
762	Brown-Sequard Syndrome	2.2%
763	Lissencephaly	2.2%
764	Polymicrogyria	2.2%
765	Pachygyria	2.2%
766	Schizencephaly	2.2%
767	Lockjaw	2.2%
768	Allodynia	2.2%
769	Lead Poisoning, Nervous System, Childhood	2.2%
770	Lead Poisoning, Nervous System, Adult	2.2%
771	Periventricular Nodular Heterotopia	2.2%
772	Ageusia	2.2%
773	Neuronal Ceroid-Lipofuscinoses	2.2%
774	Noonan Syndrome	2.2%
775	Adams-Stokes Syndrome	2.1%
776	Atrioventricular Block	2.1%
777	Bundle-Branch Block	2.1%
778	Atrial Premature Complexes	2.1%
779	Sinoatrial Block	2.1%
780	Tachycardia, Paroxysmal	2.1%
781	Supraventricular tachycardia	2.1%
782	Tachycardia, Ventricular	2.1%
783	Wolff-Parkinson-White Syndrome	2.1%
784	Tachycardia, Reciprocating	2.1%
785	Aortopulmonary Septal Defect	2.1%
786	Double Outlet Right Ventricle	2.1%
787	Endocardial Cushion Defects	2.1%
788	Myocardial bridging	2.1%
789	Aorticopulmonary Septal Defect	2.1%
790	Aicardi's syndrome	2%
791	Subacute Bacterial Endocarditis	2%
792	Hoarseness	2%
793	Cockayne Syndrome	2%
794	Alexia	2%
795	Polyradiculopathy	2%
796	Dyslexia	2%
797	Marfan Syndrome	2%
798	Alcohol Withdrawal Delirium	2%
799	Sinus Arrhythmia	2%
800	Atrial Fibrillation	2%
801	Atrial Flutter	2%
802	Edema, Cardiac	2%
803	Ventricular Fibrillation	2%
804	Ventricular Flutter	2%
805	Parasystole	2%
806	Paroxysmal atrial fibrillation	2%
807	Bradycardia	2%
808	Diabetic Cardiomyopathies	2%
809	Eye Injuries	1.9%
810	Cardiomyopathy, Alcoholic	1.9%
811	Ectopia Cordis	1.9%
812	Sudden Cardiac Death	1.9%
813	Left Ventricular Hypertrophy	1.9%
814	Right Ventricular Hypertrophy	1.9%
815	Optic Atrophy, Hereditary, Leber	1.9%
816	Single umbilical artery	1.9%
817	Chagas Cardiomyopathy	1.9%
818	Muscular Dystrophy	1.9%
819	Congenital nystagmus	1.9%
820	Orbital Myositis	1.9%
821	Diplopia	1.9%
822	Muscle Rigidity	1.9%
823	Muscle Spasticity	1.9%
824	Scotoma	1.9%
825	Photophobia	1.9%
826	Cogwheel Rigidity	1.9%
827	Hemifacial Spasm	1.9%
828	Amaurosis	1.9%
829	Blindness	1.9%
830	Nuchal Rigidity	1.9%
831	Pyomyositis	1.9%
832	Agnosia	1.9%
833	Apraxias	1.9%
834	Hallucinations	1.9%
835	Hemianopsia	1.9%
836	Hyperacusis	1.9%
837	Tinnitus	1.9%
838	Visual Agnosia	1.9%
839	Anosognosia	1.9%
840	Wernicke-Korsakoff Syndrome	1.9%
841	Phonophobia	1.9%
842	Hearing Loss	1.9%
843	Sarcopenia	1.9%
844	Romano-Ward Syndrome	1.8%
845	Holoprosencephaly	1.8%
846	Neurofibrosarcoma	1.8%
847	Amnesia	1.6%
848	Delirium	1.6%
849	Dissociative Amnesia	1.6%
850	Color blindness	1.6%
851	Global Amnesia	1.6%
852	Cri-du-Chat Syndrome	1.6%
853	Down Syndrome	1.6%
854	Trisomy 21	1.6%
855	Dyspnea, Paroxysmal	1.6%
856	POEMS Syndrome	1.6%
857	Meningioma	1.6%
858	Microcephaly	1.6%
859	Macrocephaly	1.6%
860	Hypokalemic periodic paralysis	1.6%
861	Aortic Valve Prolapse	1.6%
862	Tricuspid Valve Prolapse	1.6%
863	Takotsubo Cardiomyopathy	1.6%
864	Sleep Apnea, Obstructive	1.6%
865	Sleep Apnea, Central	1.6%
866	Porencephaly	1.6%
867	Narcolepsy	1.6%
868	Trigeminal Neuralgia	1.6%
869	Kleine-Levin Syndrome	1.6%
870	Tachycardia, Atrioventricular Nodal Reentry	1.6%
871	Tachycardia, Ectopic Atrial	1.6%
872	Tachycardia, Ectopic Junctional	1.6%
873	Sinus Tachycardia	1.6%
874	Torsades de Pointes	1.6%
875	Accelerated Idioventricular Rhythm	1.6%
876	Agraphia	1.6%
877	Anomia	1.6%
878	Cluttering	1.6%
879	Language Development Disorders	1.6%
880	Speech Disorders	1.6%
881	Syncope	1.6%
882	Stupor	1.6%
883	Dysgraphia	1.6%
884	Presyncope	1.6%
885	Dyslalia	1.6%
886	Truncus Arteriosus, Persistent	1.6%
887	Prader-Willi Syndrome	1.4%
888	Phantom pain	1.4%
889	Phantom Limb Pain	1.4%
890	Eye Burns	1.4%
891	Welander Distal Myopathy	1.3%
892	Amaurosis Fugax	1.3%
893	Blindness, Cortical	1.3%
894	Dyscalculia	1.3%
895	Rett Syndrome	1.3%
896	Deafness	1.3%
897	Hearing Loss, Sudden	1.3%
898	Gerstmann Syndrome	1.3%
899	Hearing Loss, Bilateral	1.3%
900	Hearing Loss, High-Frequency	1.3%
901	Hearing Loss, Mixed Conductive-Sensorineural	1.3%
902	Prosopagnosia	1.3%
903	Apraxia, Ideomotor	1.3%
904	Charles Bonnet Syndrome	1.3%
905	Hearing Loss, Unilateral	1.3%
906	Complete Hearing Loss	1.3%
907	Alien Hand Syndrome	1.3%
908	Deaf Mutism	1.3%
909	Sinus Arrest, Cardiac	1.3%
910	Cataplexy	1.3%
911	Aphasia	1.3%
912	Articulation Disorders	1.3%
913	Echolalia	1.3%
914	Stuttering	1.3%
915	Dysphasia	1.3%
916	Turner Syndrome	1.2%
917	Dermatomyositis	1.2%
918	Corneal Scar	1.2%
919	Muscular Dystrophy, Duchenne	1.2%
920	Retrograde amnesia	1.1%
921	Amnesia, Anterograde	1.1%
922	Rubinstein-Taybi Syndrome	1.1%
923	Dysarthria	1.1%
924	Mutism	1.1%
925	Selective Mutism	1.1%
926	Fragile X Syndrome	1%
927	Alexia, Pure	0.9%
928	Corneal Perforation	0.9%
929	Kartagener Syndrome	0.9%
930	Mucopolysaccharidosis II	0.7%

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