MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Manganese Poisoning

(UMLS:C0677050)

Definition:: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
UMLS ID:: C0677050
MeSH ID:: D020149

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.720.475.500

Classification 2:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.723.522.813

Synonym(s)

Manganese Poisoning

MANGANISM

Manganese poisoning

Manganism

Poisoning by manganese

Poisoning caused by manganese

manganese poison

manganese poisoning

manganism

10.

poisoning by manganese and compounds

11.

poisoning by manganese and its compounds

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Ascorbic Acid	21940818	CTD
2	Estradiol	19383943 19453300 29183790	CTD
3	Lactic Acid	21940818	CTD
4	Levodopa	123156	CTD
5	Manganese Compounds	View details 12009774 12171760 15010209 15183009 15681813 16393669 16417967 16551646 16568477 16934782 17467022 17615110 17662456 18041089 18284614 18771689 19383943 19453300 20188756 20648640 20865164 21107535 21310168 21384399 21493178 21812036 22281203 22285144 25149416 29429640	CTD
6	Nitric Oxide	15010209 18041089 22174044	CTD
7	Riluzole	19615351	CTD
8	Silymarin	22033861	CTD
9	Tamoxifen	19383943 19453300 29183790	CTD
10	carbidopa, levodopa drug combination	20865164	CTD
11	gamma-Aminobutyric Acid	18771689	CTD
12	manganese sulfate	12387356	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Mercury Poisoning, Nervous System	40.5%
2	Lead Poisoning, Nervous System	40.5%
3	Arsenic Poisoning	39%
4	Lead Poisoning, Nervous System, Childhood	31.4%
5	Lead Poisoning, Nervous System, Adult	31.4%
6	Cadmium poisoning	31.1%
7	Lead Poisoning	31.1%
8	Mercury Poisoning	31.1%
9	Acrodynia	27.9%
10	Argyria	23.3%
11	Neuroleptic Malignant Syndrome	22.1%
12	Alcohol-Induced Disorders, Nervous System	22.1%
13	Fluoride Poisoning	20.5%
14	Food Poisoning	20.5%
15	Gas Poisoning	20.5%
16	Mycotoxicosis	20.5%
17	Plant Poisoning	20.5%
18	Organophosphate poisoning	20.5%
19	Mushroom Poisoning	20%
20	Akathisia, Drug-Induced	19.3%
21	MPTP Poisoning	19.2%
22	Botulism	19%
23	Dyskinesia, Drug-Induced	18.1%
24	Chemical and Drug Induced Liver Injury	16.7%
25	Bites and Stings	16.1%
26	Neurotoxicity Syndromes	16.1%
27	Water Intoxication	15.3%
28	Psychoses, Substance-Induced	13.8%
29	Carbon Monoxide Poisoning	13.3%
30	Ciguatera Poisoning	13.3%
31	Ergotism	13.3%
32	Shellfish Poisoning	13.3%
33	Alcohol Withdrawal Seizures	12.9%
34	Cranial nerve diseases	11.9%
35	Demyelinating Diseases	11.9%
36	Demyelination	11.9%
37	Drug toxicity	11.9%
38	Neuromuscular Diseases	11.9%
39	Chronobiology Disorders	11.9%
40	Alcohol Withdrawal Delirium	11.3%
41	Chemical and Drug Induced Liver Injury, Chronic	10.7%
42	Motor Neuron Disease	10.3%
43	Insect Bites and Stings	10.2%
44	Salmonella food poisoning	9.9%
45	Multiple System Atrophy	9.5%
46	Drug abuse	9.3%
47	Substance Dependence	9.3%
48	Substance-Related Disorders	9.3%
49	Trauma, Nervous System	9.3%
50	Drug Dependence	9.3%
51	Stiff-Person Syndrome	9.1%
52	Nervous System Neoplasms	8.9%
53	Neurologic Manifestations	8.9%
54	Ocular Motility Disorders	8.6%
55	Cyclophoria	8.6%
56	Encephalomyelitis	8.5%
57	Polyradiculoneuropathy	8.5%
58	Prion Diseases	8.5%
59	Autonomic Dysreflexia	8.5%
60	Complex Regional Pain Syndromes	8.5%
61	Polyradiculoneuritis	8.5%
62	Restless Legs Syndrome	8.3%
63	Psychoses, Alcoholic	8.2%
64	Tick Paralysis	8.2%
65	Spinal Muscular Atrophy	8%
66	Progressive Muscular Atrophy	8%
67	Subacute Combined Degeneration	7.7%
68	Meningoencephalitis	7.7%
69	Parkinson Disease	7.6%
70	Amyotrophic Lateral Sclerosis	7.6%
71	Marchiafava-Bignami Disease	7.6%
72	Ophthalmoplegic Migraine	7.5%
73	Sleep Wake Disorders	7.2%
74	Spinal Cord Injuries	7%
75	Lewy Body Disease	6.9%
76	Peripheral Nerve Injuries	6.8%
77	Guillain-Barre Syndrome	6.8%
78	Brain Diseases	6.8%
79	Dysautonomia	6.8%
80	Meningitis	6.8%
81	Movement Disorders	6.8%
82	Pachymeningitis	6.8%
83	Spinal Cord Diseases	6.8%
84	Anticholinergic Syndrome	6.8%
85	Vagus Nerve Disorder	6.8%
86	Glossopharyngeal Neuralgia	6.8%
87	Abducens Nerve Diseases	6.8%
88	Serotonin Syndrome	6.8%
89	Neuromuscular Junction Diseases	6.8%
90	Tauopathies	6.8%
91	Propofol Infusion Syndrome	6.8%
92	Trochlear Nerve Diseases	6.8%
93	Peripheral Nervous System Diseases	6.8%
94	Striatonigral Degeneration	6.8%
95	Myasthenia Gravis	6.8%
96	Asterixis	6.8%
97	Ballismus	6.8%
98	Dandy-Walker Syndrome	6.7%
99	Myelitis	6.7%
100	Progressive bulbar palsy	6.7%
101	Bulbar palsy	6.7%
102	Pneumocephalus	6.6%
103	Poliomyelitis	6.6%
104	Causalgia	6.6%
105	Progressive supranuclear palsy	6.2%
106	Leukoencephalitis, Acute Hemorrhagic	6.1%
107	Epidural Abscess	6%
108	Olfactory Nerve Injuries	6%
109	Myelinolysis, Central Pontine	6%
110	Miller Fisher Syndrome	6%
111	Myelitis, Transverse	5.9%
112	Chronic Fatigue Syndrome	5.9%
113	Lambert-Eaton Myasthenic Syndrome	5.9%
114	Shy-Drager Syndrome	5.9%
115	Sleep Disorders, Circadian Rhythm	5.8%
116	Reflex Sympathetic Dystrophy	5.8%
117	Subdural Effusion	5.8%
118	Parkinsonian Disorders	5.8%
119	Nocturnal Myoclonus Syndrome	5.8%
120	Encephalomyelitis, Acute Disseminated	5.8%
121	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.8%
122	Central Nervous System Cysts	5.6%
123	Neuromyelitis Optica	5.6%
124	Opsoclonus-Myoclonus Syndrome	5.6%
125	Dystonia Musculorum Deformans	5.5%
126	Central Nervous System Infection	5.4%
127	Myopathy	5.4%
128	Optic Neuropathy	5.4%
129	Brain Injuries	5.3%
130	Brain Neoplasms	5.3%
131	Multiple Sclerosis	5.3%
132	Spinal Cord Neoplasms	5.3%
133	Facial Nerve Injuries	5.2%
134	Facial Nerve Diseases	5.2%
135	Craniocerebral Trauma	5.2%
136	Marijuana Abuse	5.2%
137	Opioid-Related Disorders	5.2%
138	Nicotine Dependence	5.2%
139	Opioid abuse	5.2%
140	Parasomnia	5.2%
141	Phencyclidine Abuse	5.2%
142	Substance Abuse, Intravenous	5.2%
143	Substance Withdrawal Syndrome	5.2%
144	Tobacco Use Disorder	5.2%
145	Alcohol-Related Disorders	5.2%
146	Amphetamine-Related Disorders	5.2%
147	Cocaine-Related Disorders	5.2%
148	Dyssomnias	5.2%
149	Metabolic Side Effects of Drugs and Substances	5.2%
150	Vestibulocochlear Nerve Diseases	5.1%
151	Decerebrate State	5.1%
152	Hemiparesis	5.1%
153	Hydranencephaly	5.1%
154	Meningism	5.1%
155	Neural Tube Defects	5.1%
156	Paresis	5.1%
157	Seizures	5.1%
158	Sensation Disorders	5.1%
159	Tethered Cord Syndrome	5.1%
160	Central Nervous System Neoplasms	5.1%
161	Complex partial seizures	5.1%
162	Injection Site Reaction	5.1%
163	Iniencephaly	5.1%
164	Craniorachischisis	5.1%
165	Exencephaly	5.1%
166	Monoparesis	5.1%
167	Septo-Optic Dysplasia	5.1%
168	Cortical Dysplasia	5.1%
169	Neurogenic Inflammation	5.1%
170	Gait Disorders, Neurologic	5.1%
171	Neuromuscular Manifestations	5.1%
172	Infusion site reaction	5.1%
173	Malformations of Cortical Development	5.1%
174	Drug Overdose	5%
175	Sweating, Gustatory	5%
176	Auriculotemporal Syndrome	5%
177	Horner Syndrome	5%
178	Leukoencephalopathy, Progressive Multifocal	4.9%
179	Meige Syndrome	4.9%
180	Brachial Plexus Neuritis	4.9%
181	Neuralgic Amyotrophy	4.9%
182	Cerebral Ventriculitis	4.9%
183	Epilepsy, Post-Traumatic	4.9%
184	Scrapie	4.7%
185	Central Cord Syndrome	4.7%
186	Limbic Encephalitis	4.7%
187	Presenile dementia	4.6%
188	Senile dementia	4.6%
189	Meningitis, Bacterial	4.6%
190	Meningitis, Fungal	4.6%
191	Chorea	4.6%
192	Huntington Disease	4.6%
193	Myasthenia Gravis, Autoimmune, Experimental	4.5%
194	Tarsal Tunnel Syndrome	4.5%
195	Cauda Equina Syndrome	4.5%
196	Lafora Disease	4.5%
197	Unverricht-Lundborg Syndrome	4.5%
198	Posterior Leukoencephalopathy Syndrome	4.5%
199	Posterior reversible encephalopathy syndrome	4.5%
200	Brain Abscess	4.5%
201	Ophthalmoplegia	4.5%
202	External Ophthalmoplegia	4.5%
203	Akinetic Mutism	4.4%
204	Anoxic Encephalopathy	4.4%
205	Arachnoiditis	4.4%
206	Basal Ganglia Diseases	4.4%
207	Brain Damage, Chronic	4.4%
208	Cerebellar Diseases	4.4%
209	Encephalitis	4.4%
210	Encephalomalacia	4.4%
211	Epilepsy	4.4%
212	Hydrocephalus	4.4%
213	Congenital Hydrocephalus	4.4%
214	Hypothalamic Diseases	4.4%
215	Aseptic Meningitis	4.4%
216	Neuritis	4.4%
217	Polyneuritis	4.4%
218	Radiculitis	4.4%
219	Syringomyelia	4.4%
220	Thalamic Diseases	4.4%
221	Intracranial Hypertension	4.4%
222	Polyneuropathy	4.4%
223	Mononeuritis	4.4%
224	Aura	4.4%
225	Alcohol-Induced Disorders	4.4%
226	Leukoencephalopathy	4.4%
227	Essential Tremor	4.4%
228	Neuroaxonal Dystrophies	4.4%
229	Familial Tremor	4.4%
230	Headache Disorders	4.4%
231	Mononeuropathies	4.4%
232	Intracranial Hypotension	4.4%
233	Brachial Plexus Neuropathies	4.4%
234	Radiculopathy	4.4%
235	Mononeuropathy Multiplex	4.4%
236	Nerve Root Compression	4.4%
237	Brain Edema	4.4%
238	Brain Hypoxia	4.4%
239	Aqueductal Stenosis	4.4%
240	Pneumorrhachis	4.4%
241	Writer's Cramp	4.4%
242	Charcot-Marie-Tooth Disease	4.4%
243	Lupus Vasculitis, Central Nervous System	4.4%
244	Cerebellar Neoplasms	4.3%
245	Vasculitis, Central Nervous System	4.3%
246	Jet Lag Syndrome	4.3%
247	Pupil Disorders	4.2%
248	Neurobehavioral Manifestations	4.2%
249	Neonatal Abstinence Syndrome	4.2%
250	Canavan Disease	4.1%
251	Alexander Disease	4.1%
252	Brain Death	4.1%
253	Coma, Post-Head Injury	4.1%
254	Paraneoplastic Encephalomyelitis	4.1%
255	Myoclonic Epilepsy	4.1%
256	Epilepsy, Temporal Lobe	4.1%
257	Epilepsy, Rolandic	4.1%
258	Benign Rolandic Epilepsy	4.1%
259	Uveomeningoencephalitic Syndrome	4.1%
260	Dementia, Vascular	4.1%
261	Brain Hemorrhage, Traumatic	4%
262	Sturge-Weber Syndrome	4%
263	Vertigo	4%
264	Tuberous Sclerosis	4%
265	Friedreich Ataxia	4%
266	Creutzfeldt-Jakob disease	3.9%
267	Basal Ganglia Cerebrovascular Disease	3.9%
268	Ataxia Telangiectasia	3.9%
269	Brain Injuries, Diffuse	3.9%
270	Traumatic Brain Injury	3.9%
271	Cerebellar Ataxia	3.9%
272	Supratentorial Neoplasms	3.9%
273	Torticollis	3.9%
274	Multiple Sclerosis, Chronic Progressive	3.9%
275	Multiple Sclerosis, Relapsing-Remitting	3.9%
276	Amblyopia	3.9%
277	Myotonia Congenita	3.9%
278	Vocal Cord Paralysis	3.9%
279	Paraneoplastic Cerebellar Degeneration	3.8%
280	Cerebrospinal Fluid Otorrhea	3.8%
281	Cerebrospinal Fluid Rhinorrhea	3.8%
282	Neuritis, Autoimmune, Experimental	3.8%
283	Gait Ataxia	3.8%
284	Tuberculosis, Meningeal	3.7%
285	Carotid Artery Injuries	3.7%
286	Juvenile Myoclonic Epilepsy	3.6%
287	Myoclonic Epilepsies, Progressive	3.6%
288	Carpal Tunnel Syndrome	3.6%
289	Vascular Headaches	3.6%
290	neurofibroma	3.6%
291	Hypoxia-Ischemia, Brain	3.6%
292	Sciatica	3.6%
293	Tardive Dyskinesia	3.6%
294	Persistent Vegetative State	3.6%
295	Myotonic Dystrophy	3.5%
296	Voice Disorders	3.4%
297	Voice Disturbance	3.4%
298	Cardiotoxicity	3.4%
299	Hepatolenticular Degeneration	3.4%
300	Brain Diseases, Metabolic	3.4%
301	Cerebrovascular Disorders	3.4%
302	Myositis	3.4%
303	Optic Atrophy	3.4%
304	Optic Neuritis	3.4%
305	Papilledema	3.4%
306	Strabismus	3.4%
307	Tolosa-Hunt Syndrome	3.4%
308	Cerebrovascular Insufficiency	3.4%
309	Isaacs syndrome	3.4%
310	Dementia	3.4%
311	Myotonic Disorders	3.4%
312	Central Nervous System Fungal Infections	3.4%
313	Conus Medullaris Syndrome	3.4%
314	Myasthenic Syndromes, Congenital	3.4%
315	Spinal Cord Vascular Diseases	3.4%
316	Smith-Magenis syndrome	3.4%
317	Dural Arteriovenous Fistula	3.4%
318	Alice in Wonderland Syndrome	3.3%
319	Alcohol Use Disorder	3.3%
320	Alcoholic Intoxication	3.3%
321	Diabetic Neuropathies	3.3%
322	Facial Injuries	3.3%
323	Facial Neuralgia	3.3%
324	Heroin Dependence	3.3%
325	Morphine Dependence	3.3%
326	Alcohol abuse	3.3%
327	Diabetic Amyotrophy	3.3%
328	Diabetic Autonomic Neuropathy	3.3%
329	Sleep Talking	3.3%
330	Sleep Disorders, Intrinsic	3.3%
331	Orthostatic intolerance	3.3%
332	Anosmia	3.3%
333	Ataxia	3.3%
334	Athetosis	3.3%
335	Catalepsy	3.3%
336	Dystonia	3.3%
337	Hemiplegia	3.3%
338	Locked-In Syndrome	3.3%
339	Meningeal Neoplasms	3.3%
340	Meningomyelocele	3.3%
341	Muscle Hypertonia	3.3%
342	Muscle hypotonia	3.3%
343	Myoclonus	3.3%
344	Myotonia	3.3%
345	Neuralgia	3.3%
346	Paraplegia	3.3%
347	Pseudobulbar Palsy	3.3%
348	Quadriplegia	3.3%
349	Spasm	3.3%
350	Spastic Paraplegia	3.3%
351	Status Epilepticus	3.3%
352	Taste Disorders	3.3%
353	Tremor	3.3%
354	Spina Bifida	3.3%
355	Monoplegia	3.3%
356	Hypokinesia	3.3%
357	Paraparesis	3.3%
358	Bradykinesia	3.3%
359	Waxy flexibility	3.3%
360	Action Tremor	3.3%
361	Resting Tremor	3.3%
362	Dysosmia	3.3%
363	Quadriparesis	3.3%
364	Olfaction Disorders	3.3%
365	Myokymia	3.3%
366	Vestibular Neuronitis	3.3%
367	Somatosensory Disorders	3.3%
368	Neuropathic pain	3.3%
369	Hyperkinesia	3.3%
370	Intention tremor	3.3%
371	Cerebral Palsy	3.3%
372	Epilepsies, Partial	3.3%
373	Epilepsy, Generalized	3.3%
374	Leukomalacia, Periventricular	3.3%
375	Pseudotumor Cerebri	3.3%
376	Sciatic Neuropathy	3.3%
377	Hypertensive Encephalopathy	3.3%
378	Ulnar Neuropathies	3.3%
379	Lesion of Sciatic Nerve	3.3%
380	Simple Partial Seizures	3.3%
381	Epilepsy, Reflex	3.3%
382	Ulnar Neuritis	3.3%
383	Radial nerve compression	3.3%
384	Radial Tunnel Syndrome	3.3%
385	Peroneal Neuropathies	3.3%
386	Radial Neuropathy	3.3%
387	Median Neuropathy	3.3%
388	Sciatic Nerve Palsy	3.3%
389	Femoral Neuropathy	3.3%
390	Tibial Neuropathy	3.3%
391	Ulnar Nerve Palsy	3.3%
392	Postural Orthostatic Tachycardia Syndrome	3.3%
393	Radial nerve palsy	3.3%
394	Headache Disorders, Primary	3.3%
395	Headache Disorders, Secondary	3.3%
396	Medication overuse headache	3.3%
397	Wernicke Encephalopathy	3.3%
398	Akathisia	3.3%
399	Restlessness	3.3%
400	Psychomotor Agitation	3.3%
401	Cubital Tunnel Syndrome	3.2%
402	Brain Concussion	3.2%
403	Diffuse Axonal Injury	3.2%
404	Brain Stem Neoplasms	3.2%
405	Pituitary Adenoma	3.1%
406	Pituitary Neoplasms	3.1%
407	Optic Nerve Glioma	3.1%
408	Toxoplasmosis, Cerebral	3.1%
409	Vertebral Artery Dissection	3%
410	Amnesia, Transient Global	3%
411	Gait Apraxia	3%
412	Meningitis, Cryptococcal	3%
413	Refsum Disease	3%
414	Meningitis, Listeria	3%
415	Meningitis, Haemophilus	3%
416	Meningitis, Pneumococcal	3%
417	Frontotemporal dementia	3%
418	Basal Ganglia Hemorrhage	2.9%
419	Choroid Plexus Papilloma	2.9%
420	Reflex, Abnormal	2.8%
421	Hyporeflexia	2.8%
422	Hyperreflexia	2.8%
423	Alstrom Syndrome	2.8%
424	Mitochondrial Encephalomyopathies	2.8%
425	Hand-Arm Vibration Syndrome	2.8%
426	Vision Disorders	2.8%
427	Metamorphopsia	2.8%
428	Visual Impairment	2.8%
429	Pituitary Apoplexy	2.7%
430	Fibromyalgia	2.7%
431	Optic Neuropathy, Ischemic	2.7%
432	Anterior Ischemic Optic Neuropathy	2.7%
433	Central Nervous System Bacterial Infections	2.7%
434	Medial Tibial Stress Syndrome	2.7%
435	Polyradiculopathy	2.7%
436	Post-Traumatic Headache	2.7%
437	Tension Headache	2.7%
438	Epilepsy, Complex Partial	2.7%
439	Migraine Disorders	2.7%
440	Abdominal Migraine	2.7%
441	Status Migrainosus	2.7%
442	Cervicogenic Headache	2.7%
443	Brain Contusion	2.7%
444	Facial Hemiatrophy	2.7%
445	Melkersson-Rosenthal Syndrome	2.7%
446	Mitochondrial Myopathies	2.7%
447	Brain Infarction	2.7%
448	Anisocoria	2.7%
449	Confusion	2.7%
450	Facial paralysis	2.7%
451	Lethargy	2.7%
452	Memory Disorders	2.7%
453	Muscle Cramp	2.7%
454	Perceptual Disorders	2.7%
455	Psychomotor Disorders	2.7%
456	Tonic Pupil	2.7%
457	Eosinophilia-Myalgia Syndrome	2.7%
458	Anhedonia	2.7%
459	Disorientation	2.7%
460	Facial Paresis	2.7%
461	Memory Loss	2.7%
462	Hemisensory Neglect	2.7%
463	Dysacusis	2.7%
464	Subarachnoid Hemorrhage, Traumatic	2.7%
465	Carotid Artery, Internal, Dissection	2.7%
466	Drug Eruptions	2.7%
467	Sleep Bruxism	2.7%
468	Subacute Sclerosing Panencephalitis	2.7%
469	Anencephaly	2.6%
470	Meningocele	2.6%
471	Muscular Atrophy	2.6%
472	Respiratory Paralysis	2.6%
473	Binge Drinking	2.6%
474	Encephalocele	2.6%
475	Putaminal Hemorrhage	2.6%
476	Tetany	2.6%
477	Pituitary Diseases	2.6%
478	Infarction, Middle Cerebral Artery	2.6%
479	Infarction, Anterior Cerebral Artery	2.6%
480	Infarction, Posterior Cerebral Artery	2.6%
481	Classical Lissencephalies and Subcortical Band Heterotopias	2.5%
482	Amyloid Neuropathies, Familial	2.5%
483	Thoracic Outlet Syndrome	2.5%
484	Cardiomyopathy, Alcoholic	2.5%
485	Carotid Artery Diseases	2.5%
486	Brain Ischemia	2.5%
487	Esotropia	2.5%
488	Exotropia	2.5%
489	Hypotension, Orthostatic	2.5%
490	Sleep Apnea Syndromes	2.5%
491	Cerebrovascular accident	2.5%
492	Polymyositis	2.5%
493	Kluver-Bucy Syndrome	2.5%
494	Pancreatitis, Alcoholic	2.5%
495	Vasospasm, Intracranial	2.5%
496	Spinal Cord Ischemia	2.5%
497	Intracranial Arterial Diseases	2.5%
498	Post-Exercise Hypotension	2.5%
499	Adrenoleukodystrophy	2.5%
500	Disorders of Excessive Somnolence	2.5%
501	Sleep Initiation and Maintenance Disorders	2.5%
502	Night Terrors	2.5%
503	Somnambulism	2.5%
504	Trigeminal Nerve Disorder	2.5%
505	Transient Insomnia	2.5%
506	Sleep Paralysis	2.5%
507	Chronic Insomnia	2.5%
508	REM Sleep Behavior Disorder	2.5%
509	Hypersomnia	2.5%
510	Auditory Perceptual Disorders	2.5%
511	Cluster Headache	2.5%
512	Migraine with Aura	2.5%
513	Familial Hemiplegic Migraine	2.5%
514	Chronic Paroxysmal Hemicrania	2.5%
515	SUNCT Syndrome	2.5%
516	Paroxysmal Hemicrania	2.5%
517	Dermal Sinus	2.4%
518	Dysgeusia	2.4%
519	Formication	2.4%
520	Hyperalgesia	2.4%
521	Hyperesthesia	2.4%
522	Hypesthesia	2.4%
523	Language Disorders	2.4%
524	Numbness	2.4%
525	Paresthesia	2.4%
526	Paraparesis, Spastic	2.4%
527	Spina Bifida Cystica	2.4%
528	Trismus	2.4%
529	Spina Bifida Occulta	2.4%
530	Epilepsia Partialis Continua	2.4%
531	Hypogeusia	2.4%
532	Meningeal Carcinomatosis	2.4%
533	Brown-Sequard Syndrome	2.4%
534	Lissencephaly	2.4%
535	Polymicrogyria	2.4%
536	Pachygyria	2.4%
537	Schizencephaly	2.4%
538	Lockjaw	2.4%
539	Allodynia	2.4%
540	Periventricular Nodular Heterotopia	2.4%
541	Ageusia	2.4%
542	Tuberculosis, Central Nervous System	2.4%
543	Cerebral Infarction	2.4%
544	Brain Stem Infarctions	2.4%
545	Acoustic Neuroma	2.4%
546	Giant Cell Arteritis	2.4%
547	Temporal Arteritis	2.4%
548	Alexia	2.3%
549	Dyslexia	2.3%
550	Duane Retraction Syndrome	2.3%
551	Lateral Medullary Syndrome	2.3%
552	Consciousness Disorders	2.3%
553	Mental Retardation	2.3%
554	Muscle Weakness	2.3%
555	Depressed Level of Consciousness	2.3%
556	Mental deficiency	2.3%
557	Intellectual Disability	2.3%
558	Mobius Syndrome	2.2%
559	Bell Palsy	2.2%
560	Catatonia	2.2%
561	Herpes Zoster Oticus	2.2%
562	Familial Periodic Paralysis	2.2%
563	Aphonia	2.2%
564	Sleep Deprivation	2.2%
565	Dysphonia	2.2%
566	Moyamoya Disease	2.2%
567	MELAS Syndrome	2.2%
568	Neurofibrosarcoma	2.2%
569	West Nile Fever	2.2%
570	Hematoma, Subdural	2.1%
571	Hematoma, Epidural, Cranial	2.1%
572	Empty Sella Syndrome	2.1%
573	Hyperpituitarism	2.1%
574	Hypopituitarism	2.1%
575	Hypophysitis	2.1%
576	Eye Injuries	2.1%
577	Cerebral Arterial Diseases	2%
578	Vertebrobasilar Insufficiency	2%
579	Anterior Spinal Artery Syndrome	2%
580	Basilar Artery Stenosis	2%
581	Vertebral Artery Stenosis	2%
582	Sleep Apnea, Obstructive	2%
583	Sleep Apnea, Central	2%
584	Intracranial Hemorrhage, Hypertensive	2%
585	Transient Cerebral Ischemia	2%
586	Narcolepsy	2%
587	Trigeminal Neuralgia	2%
588	Kleine-Levin Syndrome	2%
589	Agraphia	2%
590	Anomia	2%
591	Cluttering	2%
592	Language Development Disorders	2%
593	Speech Disorders	2%
594	Syncope	2%
595	Stupor	2%
596	Dysgraphia	2%
597	Presyncope	2%
598	Dyslalia	2%
599	Kearns-Sayre syndrome	2%
600	Muscular Dystrophy	2%
601	Congenital nystagmus	2%
602	Orbital Myositis	2%
603	Fetal Alcohol Spectrum Disorders	2%
604	Optic Atrophy, Hereditary, Leber	2%
605	Diplopia	2%
606	Muscle Rigidity	2%
607	Muscle Spasticity	2%
608	Scotoma	2%
609	Photophobia	2%
610	Cogwheel Rigidity	2%
611	Hemifacial Spasm	2%
612	Amaurosis	2%
613	Blindness	2%
614	Nuchal Rigidity	2%
615	Reye Syndrome	2%
616	Neuroaspergillosis	2%
617	Pyomyositis	2%
618	Intracranial Embolism and Thrombosis	2%
619	Hepatic Encephalopathy	2%
620	Agnosia	2%
621	Apraxias	2%
622	Hallucinations	2%
623	Hemianopsia	2%
624	Hyperacusis	2%
625	Tinnitus	2%
626	Visual Agnosia	2%
627	Anosognosia	2%
628	Wernicke-Korsakoff Syndrome	2%
629	Phonophobia	2%
630	Hearing Loss	2%
631	Acute Generalized Exanthematous Pustulosis	2%
632	Sarcopenia	2%
633	Asthma, Aspirin-Induced	1.9%
634	Myalgia	1.9%
635	Neuronal Ceroid-Lipofuscinoses	1.9%
636	Hematoma, Subdural, Intracranial	1.9%
637	Hematoma, Subdural, Chronic	1.9%
638	Hematoma, Subdural, Acute	1.9%
639	Hyperprolactinemia	1.8%
640	Subclavian Steal Syndrome	1.8%
641	Pick Disease of the Brain	1.8%
642	Cataplexy	1.8%
643	Aphasia	1.8%
644	Articulation Disorders	1.8%
645	Echolalia	1.8%
646	Stuttering	1.8%
647	Dysphasia	1.8%
648	Pseudorabies	1.7%
649	Dysarthria	1.7%
650	Aicardi's syndrome	1.7%
651	Hoarseness	1.7%
652	Amnesia	1.7%
653	Delirium	1.7%
654	Dissociative Amnesia	1.7%
655	Color blindness	1.7%
656	Global Amnesia	1.7%
657	Toxoplasmosis, Congenital	1.7%
658	Cockayne Syndrome	1.7%
659	Cri-du-Chat Syndrome	1.7%
660	Down Syndrome	1.7%
661	Brain Diseases, Metabolic, Inborn	1.7%
662	Trisomy 21	1.7%
663	Eye Burns	1.7%
664	Fatty Liver, Alcoholic	1.7%
665	Hepatitis, Alcoholic	1.7%
666	Liver Cirrhosis, Alcoholic	1.7%
667	Malaria, Cerebral	1.7%
668	POEMS Syndrome	1.6%
669	Meningioma	1.6%
670	Williams Syndrome	1.6%
671	Carotid Stenosis	1.6%
672	Intracranial Aneurysm	1.6%
673	Erythema Nodosum	1.6%
674	Serum Sickness	1.6%
675	Welander Distal Myopathy	1.6%
676	Microcephaly	1.6%
677	Macrocephaly	1.6%
678	Neurocysticercosis	1.6%
679	Amaurosis Fugax	1.6%
680	Blindness, Cortical	1.6%
681	Dyscalculia	1.6%
682	Neurosyphilis	1.6%
683	Hypokalemic periodic paralysis	1.6%
684	Intracranial Arteriosclerosis	1.6%
685	Cerebral Atherosclerosis	1.6%
686	Rett Syndrome	1.6%
687	Subarachnoid Hemorrhage	1.6%
688	Cerebral Arteriosclerosis	1.6%
689	Cerebral Hemorrhage	1.6%
690	Cerebral Thrombosis	1.6%
691	Intracranial Embolism	1.6%
692	Intracranial Thrombosis	1.6%
693	Porencephaly	1.6%
694	Deafness	1.6%
695	Hearing Loss, Sudden	1.6%
696	Gerstmann Syndrome	1.6%
697	Hearing Loss, Bilateral	1.6%
698	Hearing Loss, High-Frequency	1.6%
699	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
700	Prosopagnosia	1.6%
701	Apraxia, Ideomotor	1.6%
702	Charles Bonnet Syndrome	1.6%
703	Hearing Loss, Unilateral	1.6%
704	Complete Hearing Loss	1.6%
705	Alien Hand Syndrome	1.6%
706	Deaf Mutism	1.6%
707	Mutism	1.5%
708	Selective Mutism	1.5%
709	Acromegaly	1.5%
710	Holoprosencephaly	1.5%
711	Cerebral Amyloid Angiopathy	1.5%
712	Sinus Thrombosis, Intracranial	1.5%
713	Prader-Willi Syndrome	1.4%
714	AIDS Dementia Complex	1.4%
715	Dermatomyositis	1.4%
716	Waterhouse-Friderichsen Syndrome	1.4%
717	Corneal Scar	1.4%
718	Phantom pain	1.4%
719	Phantom Limb Pain	1.4%
720	Lyme Neuroborreliosis	1.4%
721	Alexia, Pure	1.4%
722	Muscular Dystrophy, Duchenne	1.4%
723	Cavernous Sinus Thrombosis	1.4%
724	Sagittal Sinus Thrombosis	1.4%
725	Retrograde amnesia	1.4%
726	Amnesia, Anterograde	1.4%
727	Carotid Artery Thrombosis	1.4%
728	Menkes Kinky Hair Syndrome	1.4%
729	Kernicterus	1.3%
730	Corneal Perforation	1.2%
731	Toxic Epidermal Necrolysis	1.2%
732	Stevens-Johnson Syndrome	1.2%
733	Fragile X Syndrome	1.2%
734	Nelson Syndrome	1.1%
735	Rubinstein-Taybi Syndrome	1.1%
736	Fabry Disease	1.1%
737	Prolactinoma	1.1%
738	Growth Hormone-Secreting Pituitary Adenoma	1.1%
739	Galactosemias	1%
740	Urea Cycle Disorders, Inborn	1%
741	Tyrosinemias	1%
742	Homocystinuria	0.9%
743	Leigh Disease	0.9%
744	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
745	Mucopolysaccharidosis II	0.8%
746	Glycogen storage disease type II	0.7%
747	Zellweger Syndrome	0.7%
748	Gaucher Disease	0.6%
749	Tay-Sachs Disease	0.6%
750	Niemann-Pick Disease, Type C	0.5%

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