MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tenosynovitis

(UMLS:C0039520)

Definition:: Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
UMLS ID:: C0039520
MeSH ID:: D013717

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.869.870

Synonym(s)

Tenosynovitis

Inflammation of tendon sheath

Inflammation of the tendon sheath

TENOSYNOVITIS

Tendinous synovitis

Tendovaginitis

Tenontolemmitis

Tenosynovitis, NOS

Tenovaginitis

10.

peritendinitis

11.

tendinous synovitis

12.

tendovaginitis

13.

tenosynovitis

14.

tenovaginitis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Levofloxacin	FAERS: 251 Canada Vigilance: 2	Canada Vigilance US FAERS
2	Ciprofloxacin	FAERS: 35	OFFSIDES US FAERS
3	Alendronate	FAERS: 24	OFFSIDES US FAERS
4	rofecoxib	FAERS: 17	OFFSIDES US FAERS
5	tofacitinib	FAERS: 11	US FAERS
6	Imatinib Mesylate	FAERS: 10	US FAERS
7	Sertraline	FAERS: 9	US FAERS
8	Simvastatin	FAERS: 7	US FAERS
9	Anastrozole	FAERS: 6	OFFSIDES US FAERS
10	Zoledronic Acid	FAERS: 6 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
11	exemestane	FAERS: 6	OFFSIDES US FAERS
12	Clindamycin	FAERS: 4	US FAERS
13	Fingolimod Hydrochloride	FAERS: 4	US FAERS
14	Isotretinoin	FAERS: 4	US FAERS
15	Lenalidomide	FAERS: 4	US FAERS
16	Moxifloxacin	FAERS: 4	US FAERS
17	Atorvastatin	FAERS: 3	US FAERS
18	Deferoxamine	FAERS: 3	US FAERS
19	Letrozole	FAERS: 3	OFFSIDES US FAERS
20	Medroxyprogesterone Acetate	FAERS: 3	US FAERS
21	Methotrexate	FAERS: 3	US FAERS
22	Methotrexate	FAERS: 3	US FAERS
23	Ondansetron	FAERS: 3	US FAERS
24	PCI 32765	FAERS: 3	US FAERS
25	Prednisolone	FAERS: 3	US FAERS
26	Prednisone	FAERS: 3	US FAERS
27	Sildenafil Citrate	FAERS: 3	SIDER US FAERS
28	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2	US FAERS
29	Finasteride	FAERS: 2	OFFSIDES US FAERS
30	Fluticasone	FAERS: 2	US FAERS
31	Fractals	FAERS: 2	US FAERS
32	Goserelin	FAERS: 2	US FAERS
33	Rabeprazole	FAERS: 2	OFFSIDES US FAERS
34	Sertraline	FAERS: 2	US FAERS
35	Teriparatide	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
36	benzoylecgonine	FAERS: 2	US FAERS
37	1-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol;hydron;chloride	FAERS: 1	US FAERS
38	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
39	Abiraterone Acetate	FAERS: 1	US FAERS
40	Alendronate	FAERS: 1	US FAERS
41	Azithromycin	FAERS: 1	US FAERS
42	Bortezomib	FAERS: 1	US FAERS
43	Canagliflozin	FAERS: 1	US FAERS
44	Capecitabine	FAERS: 1	US FAERS
45	Ciprofloxacin	FAERS: 1	US FAERS
46	Clarithromycin	FAERS: 1	US FAERS
47	Clomiphene	FAERS: 1	US FAERS
48	Copper	FAERS: 1	US FAERS
49	Deferasirox	FAERS: 1	US FAERS
50	Donepezil	FAERS: 1	US FAERS
51	Doxazosin	FAERS: 1	US FAERS
52	Dronedarone	FAERS: 1	US FAERS
53	Fentanyl	FAERS: 1	OFFSIDES US FAERS
54	Ferric Oxide, Saccharated	FAERS: 1	US FAERS
55	Gabapentin	FAERS: 1	US FAERS
56	Gadolinium	FAERS: 1	US FAERS
57	Lamotrigine	FAERS: 1	US FAERS
58	Meloxicam	FAERS: 1	US FAERS
59	Methylprednisolone Acetate	FAERS: 1	US FAERS
60	Milnacipran	FAERS: 1	US FAERS
61	NuvaRing	FAERS: 1	US FAERS
62	Ofloxacin	FAERS: 1	US FAERS
63	Pamidronate	FAERS: 1	US FAERS
64	Phentermine	FAERS: 1	US FAERS
65	Pregabalin	FAERS: 1	SIDER US FAERS
66	Rosuvastatin Calcium	FAERS: 1	US FAERS
67	Tacrolimus	FAERS: 1	US FAERS
68	Tamoxifen	FAERS: 1	US FAERS
69	Thyroxine	FAERS: 1	US FAERS
70	Triamcinolone Acetonide	FAERS: 1	US FAERS
71	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1	US FAERS
72	eltrombopag	FAERS: 1	US FAERS
73	nitisinone	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
74	sibutramine	FAERS: 1	US FAERS
75	tesamorelin	FAERS: 1	US FAERS
76	Acetazolamide		OFFSIDES
77	Amifostine		OFFSIDES
78	Amoxicillin		OFFSIDES
79	Aripiprazole		SIDER
80	Atorvastatin		SIDER
81	Atropine		OFFSIDES
82	Benztropine		OFFSIDES
83	Bezafibrate		SIDER
84	Bimatoprost		OFFSIDES
85	Bisacodyl		OFFSIDES
86	Brimonidine Tartrate		OFFSIDES
87	Bupropion		OFFSIDES
88	Calcitriol		OFFSIDES
89	Carboplatin		OFFSIDES
90	Celecoxib		OFFSIDES
91	Chloroquine		OFFSIDES
92	Citalopram		SIDER
93	Clobetasol		OFFSIDES
94	Daunorubicin		OFFSIDES
95	Deferoxamine		OFFSIDES
96	Delavirdine		SIDER
97	Dexamethasone		OFFSIDES
98	Dicyclomine		OFFSIDES
99	Diltiazem		OFFSIDES
100	Diphenoxylate		OFFSIDES
101	Dipyrone		OFFSIDES
102	Docetaxel		OFFSIDES
103	Doxorubicin		OFFSIDES
104	Erythromycin		OFFSIDES
105	Estazolam		OFFSIDES
106	Estradiol		OFFSIDES
107	Estrogens, Conjugated (USP)		OFFSIDES
108	Etodolac		OFFSIDES
109	Etoricoxib		SIDER
110	Fenofibrate		SIDER
111	Ferric Oxide, Saccharated	Canada Vigilance: 2	Canada Vigilance
112	Floxacillin		OFFSIDES
113	Fluoxetine		SIDER
114	Flurbiprofen		SIDER
115	Fluvoxamine		SIDER
116	Fosinopril		OFFSIDES
117	Hydrocortisone sodium succinate		OFFSIDES
118	Ibandronic Acid		OFFSIDES
119	Imipramine		OFFSIDES
120	Indinavir		OFFSIDES
121	Ipratropium		OFFSIDES
122	Ketoconazole		OFFSIDES
123	Ketorolac		OFFSIDES
124	Ketorolac Tromethamine		OFFSIDES
125	Lasofoxifene		SIDER
126	Leflunomide		OFFSIDES SIDER
127	Leuprolide		SIDER
128	Leuprolide		OFFSIDES
129	Levobunolol		OFFSIDES
130	Losartan		OFFSIDES
131	Loteprednol Etabonate		OFFSIDES
132	Melatonin		OFFSIDES
133	Mercaptopurine		OFFSIDES
134	Methylprednisolone		OFFSIDES
135	Metronidazole		OFFSIDES
136	Mirtazapine		SIDER
137	Mitoxantrone		OFFSIDES
138	Moxifloxacin		OFFSIDES
139	Mupirocin		OFFSIDES
140	Naloxone		OFFSIDES
141	Nisoldipine		SIDER
142	Nitrofurantoin		OFFSIDES
143	Nizatidine		OFFSIDES
144	Nuvocid		SIDER
145	Paclitaxel		OFFSIDES
146	Pamidronate		OFFSIDES
147	Pantoprazole		SIDER
148	Paroxetine		SIDER
149	Penicillin V		OFFSIDES
150	Pentoxifylline		OFFSIDES
151	Pergolide		SIDER
152	Pilocarpine		SIDER
153	Pramipexole		SIDER
154	Prazosin		OFFSIDES
155	Prednisone acetate		OFFSIDES
156	Progesterone		OFFSIDES
157	Raloxifene Hydrochloride		OFFSIDES
158	Ribavirin		OFFSIDES
159	Risedronic Acid		OFFSIDES
160	Selegiline		SIDER
161	Sulindac		OFFSIDES
162	Sumatriptan		OFFSIDES
163	Tamoxifen		OFFSIDES
164	Telmisartan		SIDER
165	Temazepam		OFFSIDES
166	Tenofovir		OFFSIDES
167	Terbutaline		OFFSIDES
168	Theophylline		OFFSIDES
169	Tolcapone		SIDER
170	Topiramate		OFFSIDES
171	Tramadol		OFFSIDES
172	Travoprost		OFFSIDES
173	Tretinoin		OFFSIDES
174	Triamcinolone		OFFSIDES SIDER
175	Triamterene		OFFSIDES
176	Trihexyphenidyl		OFFSIDES
177	Triprolidine		OFFSIDES
178	Vancomycin		OFFSIDES
179	Varenicline		OFFSIDES
180	Venlafaxine Hydrochloride		SIDER
181	Vitamin A		OFFSIDES
182	abacavir		OFFSIDES
183	alfuzosin		OFFSIDES
184	alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination		OFFSIDES
185	binedaline		OFFSIDES
186	cevimeline		SIDER
187	chlordiazepoxide, clidinium drug combination		OFFSIDES
188	dolasetron		OFFSIDES
189	efavirenz		OFFSIDES
190	eletriptan		SIDER
191	fexofenadine		OFFSIDES
192	nefazodone		SIDER
193	nepafenac		OFFSIDES
194	oxybutynin		SIDER
195	rasagiline		SIDER
196	rizatriptan		OFFSIDES
197	rizatriptan		OFFSIDES
198	sibutramine		SIDER
199	tegaserod		OFFSIDES
200	terconazole		OFFSIDES
201	tetrazepam		OFFSIDES
202	tizanidine		OFFSIDES
203	zaleplon		SIDER
204	ziprasidone		SIDER
205	zolmitriptan		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Enthesopathy	31.1%
2	Myofascial Pain Syndromes	31%
3	Rhabdomyolysis	31%
4	Contracture	27.9%
5	Compartment syndromes	20.9%
6	Arthrogryposis	20.8%
7	Fibromyalgia	20.7%
8	Polymyalgia Rheumatica	20.7%
9	Myositis	20.5%
10	Isaacs syndrome	20.5%
11	Myotonic Disorders	20.5%
12	Fibrodysplasia Ossificans Progressiva	20%
13	Myoglobinuria	20%
14	Myositis Ossificans	20%
15	Ischemic contracture	18.7%
16	Bone Diseases	18.5%
17	Fasciitis	18.5%
18	Foot Deformities	18.5%
19	Arthropathy	18.5%
20	Hip Contracture	17.8%
21	Medial Tibial Stress Syndrome	15.5%
22	Mitochondrial Myopathies	15.3%
23	Muscle Cramp	15.1%
24	Eosinophilia-Myalgia Syndrome	15.1%
25	Muscle Rigidity	14.9%
26	Muscle Spasticity	14.9%
27	Cogwheel Rigidity	14.9%
28	Nuchal Rigidity	14.9%
29	Osteoarthropathy, Secondary Hypertrophic	14%
30	Fasciitis, Plantar	14%
31	Anterior Compartment Syndrome	13.3%
32	Abdominal Compartment Syndrome	13.3%
33	Polymyositis	13.2%
34	Temporomandibular Joint Dysfunction Syndrome	13%
35	Chronic Fatigue Syndrome	12.9%
36	Jaw Diseases	12.8%
37	Muscle Weakness	12.2%
38	Cartilage Diseases	12.2%
39	Foot Diseases	12.2%
40	Rheumatism	12.2%
41	Chondromalacia	12.2%
42	Musculoskeletal Pain	12.1%
43	Temporomandibular Joint Disorders	12.1%
44	Familial Periodic Paralysis	12%
45	Arthritis	10.3%
46	Bone Diseases, Developmental	10.3%
47	Bursitis	10.3%
48	Hyperostosis	10.3%
49	Joint Instability	10.3%
50	Osteitis	10.3%
51	Osteitis Deformans	10.3%
52	Osteochondritis	10.3%
53	Osteochondrosis	10.3%
54	Spinal Diseases	10.3%
55	Synovitis	10.3%
56	Joint laxity	10.3%
57	Polyarthritis	10.3%
58	Frozen shoulder	10.3%
59	Patellofemoral Pain Syndrome	10.3%
60	Metatarsalgia	10.3%
61	Muscular Dystrophy	10.1%
62	Orbital Myositis	10.1%
63	Dupuytren Contracture	10%
64	Myalgia	9.9%
65	Pyomyositis	9.9%
66	Pectus carinatum	9.1%
67	Periarthritis	8.9%
68	Myotonic Dystrophy	8.6%
69	Pectus excavatum	8.5%
70	Rheumatic Fever	8.4%
71	Osteoarthritis, Spine	8.1%
72	Myotonia Congenita	7.9%
73	Platybasia	7.9%
74	Hypokalemic periodic paralysis	7.8%
75	Gout	7.8%
76	Osteoarthritis, Knee	7.7%
77	Klippel-Feil Syndrome	7.6%
78	Synostosis	7.6%
79	Welander Distal Myopathy	7.3%
80	Bone Diseases, Endocrine	7.3%
81	Ankylosing spondylitis	7.1%
82	Bone Diseases, Infectious	7%
83	Bone neoplasms	7%
84	Maxillary Diseases	7%
85	Osteopenia	7%
86	Talipes	6.9%
87	Rheumatoid Arthritis	6.8%
88	Juvenile arthritis	6.8%
89	Bone Resorption	6.8%
90	Hemarthrosis	6.8%
91	Tietze's Syndrome	6.8%
92	Limb Deformities, Congenital	6.8%
93	Craniofacial Abnormalities	6.8%
94	Aseptic Necrosis of Bone	6.8%
95	Ainhum	6.7%
96	Bunion	6.7%
97	Dysostoses	6.7%
98	Gigantism	6.7%
99	Spinal Neoplasms	6.7%
100	Spinal Stenosis	6.7%
101	Spondylitis	6.7%
102	Spondylosis	6.7%
103	Intervertebral Disc Degeneration	6.7%
104	Sacroiliitis	6.7%
105	Mitochondrial Encephalomyopathies	6.6%
106	Dermatomyositis	6.1%
107	Spondylarthropathies	5.9%
108	Muscular Dystrophy, Duchenne	5.9%
109	Craniofacial Dysostosis	5.7%
110	Rheumatoid Nodule	5.7%
111	Craniosynostosis	5.7%
112	Syndactyly	5.7%
113	Brachycephaly	5.7%
114	Arthritis, Psoriatic	5.7%
115	Arthritis, Gouty	5.4%
116	Congenital clubfoot	5.3%
117	Vertical Talus	5.3%
118	Gastroschisis	5%
119	Arthritis, Reactive	5%
120	Chondrodysplasia Punctata	4.9%
121	Enchondromatosis	4.9%
122	Lordosis	4.9%
123	Osteosclerosis	4.9%
124	Spondylolysis	4.9%
125	kyphosis	4.9%
126	Kashin-Beck Disease	4.9%
127	Discitis	4.9%
128	Acrocephalosyndactylia	4.8%
129	Felty Syndrome	4.6%
130	Arthritis, Infectious	4.5%
131	Multiple Epiphyseal Dysplasia	4.5%
132	Osteochondrodysplasias	4.5%
133	Osteomyelitis	4.4%
134	Osteoporosis	4.4%
135	Periostitis	4.4%
136	Bone Demineralization, Pathologic	4.4%
137	Post-Traumatic Osteoporosis	4.4%
138	Arthritis, Experimental	4.4%
139	Poland Syndrome	4.4%
140	Alveolar Bone Loss	4.4%
141	Amelia	4.4%
142	Arachnodactyly	4.4%
143	Ectromelia	4.4%
144	Femur Head Necrosis	4.4%
145	Hemimelia	4.4%
146	Phocomelia	4.4%
147	Sirenomelia	4.4%
148	Polydactyly	4.4%
149	Brachydactyly	4.4%
150	Plagiocephaly	4.4%
151	Lower Extremity Deformities, Congenital	4.4%
152	Upper Extremity Deformities, Congenital	4.4%
153	Osteolysis	4.4%
154	Jaw Abnormalities	4.3%
155	Nail-Patella Syndrome	4.1%
156	Giant Cell Epulis	4.1%
157	Melorheostosis	4.1%
158	Osteopetrosis	4.1%
159	Spondylolisthesis	4.1%
160	Arthralgia	4%
161	Polyarthralgia	4%
162	Congenital Hypothyroidism	3.9%
163	Tuberculosis, Spinal	3.9%
164	Rheumatoid Vasculitis	3.8%
165	Prognathism	3.8%
166	Goldenhar Syndrome	3.8%
167	Dwarfism	3.6%
168	Mandibulofacial Dysostosis	3.6%
169	Antley-Bixler Syndrome Phenotype	3.5%
170	Hip Dislocation	3.4%
171	Shoulder Dislocation	3.4%
172	Laryngomalacia	3.4%
173	Hip Dysplasia	3.4%
174	Eosinophilic Granuloma	3.3%
175	Sicca Syndrome	3.3%
176	Sjogren's Syndrome	3.3%
177	Acromegaly	3.3%
178	Joint Tuberculosis	3.3%
179	Tuberculosis, Osteoarticular	3.3%
180	Bone Tuberculosis	3.3%
181	Osteoporosis, Postmenopausal	3.3%
182	Palatal Neoplasms	3%
183	Micrognathism	3%
184	Pierre Robin Syndrome	3%
185	MELAS Syndrome	2.9%
186	Rubinstein-Taybi Syndrome	2.9%
187	Maxillofacial Abnormalities	2.7%
188	Retrognathia	2.6%
189	Kearns-Sayre syndrome	2.6%
190	Rickets	2.6%
191	Bronchomalacia	2.6%
192	Tracheomalacia	2.6%
193	Microcephaly	2.6%
194	Macrocephaly	2.6%
195	Shoulder Pain	2.6%
196	Osteogenesis Imperfecta	2.5%
197	Mastoiditis	2.4%
198	Petrositis	2.4%
199	Basal Cell Nevus Syndrome	2.3%
200	Pseudohypoparathyroidism	2.2%
201	Cleft Palate	2.1%
202	Osteomalacia	1.9%
203	Porencephaly	1.9%
204	Noonan Syndrome	1.9%
205	Marfan Syndrome	1.7%
206	Holoprosencephaly	1.7%
207	Cockayne Syndrome	1.4%
208	Radicular Cyst	1.3%
209	Nose Neoplasms	1.3%
210	Renal Osteodystrophy	1.2%
211	Renal rickets	1.2%
212	Familial Hypophosphatemic Rickets	0.6%

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