MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hepatolenticular Degeneration

(UMLS:C0019202)

Definition:: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
UMLS ID:: C0019202
MeSH ID:: D006527

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.413

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.079.493|C10.228.140.163.100.360|C10.228.662.400|C10.574.500.487

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.361|C16.320.565.189.360|C16.320.565.618.403

Classification 4:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.360|C18.452.648.189.360|C18.452.648.618.403

Synonym(s)

Hepatolenticular Degeneration

Cerebral pseudosclerosis

Copper storage disease

Disease;Wilsons

HEPATIC WILSONS DISEASE

HEPATOLENTICULAR DEGENERATION

Hepato-lenticular degeneration

Hepatocerebral degeneration

Hepatolenticular degeneration

10.

Hepatolenticular degeneration syndrome

11.

Kinnier-Wilson disease

12.

LENTICULAR DEGENERATION, PROGRESSIVE

13.

Neurohepatic degeneration

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Copper	View details 7792379 7849148 11795876 11803042 11854914 11985593 12195459 12544487 14479334 15911138 16607473 16940238 17044091 17109627 17182432 17276780 18626182 19571474 19888908 20647314 21406592 22243965 22802922 25002079 26241054	CTD
2	Ditiocarb	5048687	CTD
3	Levodopa	4192136	CTD
4	Malondialdehyde	25002079	CTD
5	Penicillamine	View details 161403 287196 736410 819461 930944 960872 1139195 1212597 1428152 1466536 1794180 1940953 2045766 2334309 2732577 3579660 3752071 4116745 4188283 4572368 4632215 5149266 5421930 5927925 5953529 6658398 6939878 7370063 7710368 7792379 7849148 8129644 8592607 8618573 8832611 9311362 9476721 9860423 10999174 11391761 11585717 12839386 14479334 14562189 15365158 17346443 22843330	CTD
6	Phenytoin	5421930	CTD
7	Pyridoxine	5421930	CTD
8	Risperidone	11748326	CTD
9	Trientine	View details 6445305 7710368 7849148 9860423 11585717 17276780 23202417	CTD
10	Zinc Acetate	View details 3579660 7710368 11585717 17346443	CTD
11	Zinc Sulfate	View details 2045766 9476721 17063115 17765927	CTD
12	cupric chloride	28926697	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Adrenoleukodystrophy	62.5%
2	Menkes Kinky Hair Syndrome	55.9%
3	Refsum Disease	52.6%
4	Galactosemias	51.2%
5	Urea Cycle Disorders, Inborn	51.2%
6	Tyrosinemias	51.2%
7	Leigh Disease	50.2%
8	Canavan Disease	47.1%
9	Alexander Disease	47.1%
10	Zellweger Syndrome	47%
11	Homocystinuria	45.5%
12	Glycogen storage disease type II	44%
13	Carbamoyl-Phosphate Synthase I Deficiency Disease	41.7%
14	Fabry Disease	40.6%
15	MELAS Syndrome	39.7%
16	Gaucher Disease	37.4%
17	Dystonia Musculorum Deformans	37.3%
18	Huntington Disease	36.4%
19	Hyperphosphaturia	34.7%
20	Amyloid Neuropathies, Familial	34.6%
21	Smith-Lemli-Opitz Syndrome	32.7%
22	Multiple System Atrophy	32.6%
23	Pseudohypoparathyroidism	32.2%
24	Niemann-Pick Disease, Type C	32.1%
25	Tay-Sachs Disease	31.9%
26	Neuronal Ceroid-Lipofuscinoses	31.8%
27	Lewy Body Disease	29.6%
28	Cockayne Syndrome	29.1%
29	Mucopolysaccharidosis II	28.9%
30	Hepatolenticular Degeneration	28.2%
31	Friedreich Ataxia	28.1%
32	Lafora Disease	27.2%
33	Unverricht-Lundborg Syndrome	27.2%
34	Meningoencephalitis	27.1%
35	Amino Acid Metabolism, Inborn Errors	26.5%
36	Carbohydrate Metabolism, Inborn Errors	26.5%
37	Progeria	26.5%
38	Lysosomal Storage Diseases	26.5%
39	Peroxisomal Disorders	26.5%
40	Familial Hypophosphatemic Rickets	26.5%
41	Hypophosphatasia	25.9%
42	Progressive supranuclear palsy	25.7%
43	Myelinolysis, Central Pontine	25.7%
44	Familial Periodic Paralysis	25.6%
45	Parkinsonian Disorders	25.5%
46	Parkinson Disease	25.2%
47	Tuberous Sclerosis	25%
48	Reye Syndrome	24.7%
49	Ichthyosis, X-Linked	24.2%
50	Hepatic Encephalopathy	24%
51	Albinism	24%
52	Dementia, Vascular	23.9%
53	Alstrom Syndrome	23.9%
54	Myotonic Dystrophy	23.8%
55	Mitochondrial Encephalomyopathies	23.5%
56	Brain Diseases, Metabolic, Inborn	23.4%
57	Ataxia Telangiectasia	23.2%
58	Dandy-Walker Syndrome	22.9%
59	Striatonigral Degeneration	22.9%
60	Lactose Intolerance	22.5%
61	Hyperhomocysteinemia	22.2%
62	Amyotrophic Lateral Sclerosis	22%
63	Mucopolysaccharidosis III	21.9%
64	Meige Syndrome	21.9%
65	Encephalomyelitis	21.6%
66	Pneumocephalus	21.6%
67	Shy-Drager Syndrome	21.5%
68	Optic Atrophy, Hereditary, Leber	21.1%
69	Basal Ganglia Cerebrovascular Disease	20.8%
70	Hypolipoproteinemias	20.8%
71	Cytochrome-c Oxidase Deficiency	20.5%
72	Myotonia Congenita	20.4%
73	Hyperlipoproteinemia Type IV	20.3%
74	Hyperlipoproteinemia Type V	20.3%
75	Hyperlipidemia, Familial Combined	19.7%
76	Sjogren-Larsson Syndrome	19.4%
77	Subdural Effusion	19.4%
78	Lupus Vasculitis, Central Nervous System	19.4%
79	Leukoencephalopathy, Progressive Multifocal	19.2%
80	Hyperlipoproteinemia Type III	19.2%
81	Brain Abscess	19.1%
82	Epidural Abscess	19.1%
83	Werner Syndrome	19.1%
84	Hypokalemic periodic paralysis	19%
85	Kernicterus	19%
86	Aicardi's syndrome	18.8%
87	Subacute Combined Degeneration	18.8%
88	Wernicke Encephalopathy	18.6%
89	Fragile X Syndrome	18.2%
90	Leukomalacia, Periventricular	18.1%
91	Renal tubular acidosis	18.1%
92	Charcot-Marie-Tooth Disease	18.1%
93	Epilepsy, Post-Traumatic	18%
94	MPTP Poisoning	18%
95	Alkaptonuria	17.9%
96	Glycogen Storage Disease	17.9%
97	Propionic acidemia	17.9%
98	Dihydropyrimidine Dehydrogenase Deficiency	17.9%
99	Cystinosis	17.9%
100	Porphyrias, Hepatic	17.9%
101	Ocular Motility Disorders	17.8%
102	Cyclophoria	17.8%
103	Marchiafava-Bignami Disease	17.7%
104	Neuroleptic Malignant Syndrome	17.4%
105	Basal Ganglia Hemorrhage	17.2%
106	Brain Diseases, Metabolic	17%
107	Prion Diseases	16.8%
108	Stiff-Person Syndrome	16.7%
109	Leukoencephalitis, Acute Hemorrhagic	16.5%
110	Asterixis	16.5%
111	Ballismus	16.5%
112	Limbic Encephalitis	16.5%
113	Myelitis	16.4%
114	Myelitis, Transverse	16.1%
115	Cystic Fibrosis	16.1%
116	Posterior Leukoencephalopathy Syndrome	16.1%
117	Posterior reversible encephalopathy syndrome	16.1%
118	Glycosuria, Renal	16.1%
119	Brain Injuries	16%
120	Brain Neoplasms	15.9%
121	Metal Metabolism, Inborn Errors	15.9%
122	Antley-Bixler Syndrome Phenotype	15.9%
123	Spinal Muscular Atrophy	15.9%
124	Progressive Muscular Atrophy	15.9%
125	Smith-Magenis syndrome	15.8%
126	Hypoalphalipoproteinemias	15.7%
127	Myasthenic Syndromes, Congenital	15.6%
128	Ophthalmoplegic Migraine	15.5%
129	Cerebellar Neoplasms	15.5%
130	Renal Aminoacidurias	15.4%
131	Fanconi Syndrome	15.4%
132	Pseudohypoaldosteronism	15.4%
133	Liddle Syndrome	15.4%
134	Wasting Syndrome	15.3%
135	Vascular Headaches	15%
136	Hypoxia-Ischemia, Brain	14.9%
137	Akinetic Mutism	14.9%
138	Anoxic Encephalopathy	14.9%
139	Brain Damage, Chronic	14.9%
140	Cerebellar Diseases	14.9%
141	Encephalitis	14.9%
142	Encephalomalacia	14.9%
143	Epilepsy	14.9%
144	Hydrocephalus	14.9%
145	Congenital Hydrocephalus	14.9%
146	Hypothalamic Diseases	14.9%
147	Thalamic Diseases	14.9%
148	Intracranial Hypertension	14.9%
149	Aura	14.9%
150	Leukoencephalopathy	14.9%
151	Neuroaxonal Dystrophies	14.9%
152	Headache Disorders	14.9%
153	Intracranial Hypotension	14.9%
154	Brain Edema	14.9%
155	Brain Hypoxia	14.9%
156	Aqueductal Stenosis	14.9%
157	Cerebral Ventriculitis	14.8%
158	Muscular Dystrophy, Duchenne	14.7%
159	Miller Fisher Syndrome	14.6%
160	Gout	14.6%
161	Putaminal Hemorrhage	14.6%
162	Pituitary Adenoma	14.6%
163	Pituitary Neoplasms	14.6%
164	Poliomyelitis	14.6%
165	Akathisia, Drug-Induced	14.5%
166	Meningitis	14.4%
167	Pachymeningitis	14.4%
168	Spinal Cord Diseases	14.4%
169	Rett Syndrome	14.3%
170	Brain Death	14.3%
171	Brain Hemorrhage, Traumatic	14.2%
172	Holoprosencephaly	14.2%
173	Opsoclonus-Myoclonus Syndrome	14.1%
174	Motor Neuron Disease	14%
175	Amblyopia	14%
176	Kartagener Syndrome	14%
177	Toxoplasmosis, Cerebral	13.9%
178	Cerebrovascular Disorders	13.9%
179	Cerebrovascular Insufficiency	13.9%
180	Dementia	13.9%
181	Myoclonic Epilepsy	13.8%
182	Epilepsy, Temporal Lobe	13.8%
183	Epilepsy, Rolandic	13.8%
184	Benign Rolandic Epilepsy	13.8%
185	Creutzfeldt-Jakob disease	13.8%
186	CHARGE Syndrome	13.7%
187	Hypercalcemia	13.7%
188	Hypocalcemia	13.7%
189	Milk-Alkali Syndrome	13.7%
190	Presenile dementia	13.6%
191	Senile dementia	13.6%
192	Glycogen Storage Disease Type I	13.6%
193	Glycogen Storage Disease Type V	13.6%
194	Central Nervous System Infection	13.5%
195	Muscular Dystrophy	13.5%
196	Dyskinesia, Drug-Induced	13.5%
197	Prader-Willi Syndrome	13.4%
198	Essential Tremor	13.3%
199	Familial Tremor	13.3%
200	Writer's Cramp	13.3%
201	Congenital Hyperinsulinism	13.2%
202	Carotid Artery Injuries	13.2%
203	Anemia, Sickle Cell	13.1%
204	Thalassemia	13.1%
205	Cri-du-Chat Syndrome	13%
206	Down Syndrome	13%
207	Trisomy 21	13%
208	Spinal Cord Injuries	12.9%
209	Meningitis, Bacterial	12.9%
210	Meningitis, Fungal	12.9%
211	Nail-Patella Syndrome	12.8%
212	Lipodystrophy	12.7%
213	Paraneoplastic Cerebellar Degeneration	12.7%
214	Amnesia, Transient Global	12.7%
215	Rickets	12.6%
216	Restless Legs Syndrome	12.6%
217	Fanconi Anemia	12.4%
218	Variegate Porphyria	12.4%
219	Acute intermittent porphyria	12.4%
220	Porphyria Cutanea Tarda	12.4%
221	Neoplastic Syndromes, Hereditary	12.4%
222	Acid-Base Imbalance	12.4%
223	Calcium Metabolism Disorders	12.4%
224	Iron Metabolism Disorders	12.4%
225	Phosphorus Metabolism Disorders	12.4%
226	Water-Electrolyte Imbalance	12.4%
227	Lipid Metabolism Disorders	12.4%
228	Mitochondrial Diseases	12.4%
229	Glucose Metabolism Disorders	12.4%
230	Frontotemporal dementia	12.3%
231	Infarction, Middle Cerebral Artery	12.3%
232	Infarction, Anterior Cerebral Artery	12.3%
233	Infarction, Posterior Cerebral Artery	12.3%
234	Multiple Epiphyseal Dysplasia	12.2%
235	Osteochondrodysplasias	12.2%
236	Pelger-Huet Anomaly	12.2%
237	Rubinstein-Taybi Syndrome	12.1%
238	Chronic Fatigue Syndrome	12.1%
239	Pituitary Apoplexy	12%
240	Marfan Syndrome	12%
241	Vasculitis, Central Nervous System	12%
242	Brain Infarction	11.9%
243	Encephalomyelitis, Acute Disseminated	11.9%
244	Beckwith-Wiedemann Syndrome	11.8%
245	Wolf-Hirschhorn Syndrome	11.8%
246	Cystinuria	11.7%
247	Xeroderma Pigmentosum	11.7%
248	Tuberculosis, Meningeal	11.7%
249	Polyradiculoneuropathy	11.6%
250	Polyradiculoneuritis	11.6%
251	Wiskott-Aldrich Syndrome	11.6%
252	Juvenile Myoclonic Epilepsy	11.5%
253	Myoclonic Epilepsies, Progressive	11.5%
254	Dwarfism	11.5%
255	Osteopenia	11.5%
256	Osteogenesis Imperfecta	11.3%
257	Chorea	11.2%
258	Arthritis, Gouty	11%
259	Lambert-Eaton Myasthenic Syndrome	11%
260	Williams Syndrome	10.8%
261	Spinal Cord Neoplasms	10.8%
262	Brain Injuries, Diffuse	10.7%
263	Traumatic Brain Injury	10.7%
264	Cerebellar Ataxia	10.7%
265	Supratentorial Neoplasms	10.7%
266	Autoimmune Lymphoproliferative Syndrome	10.6%
267	Subacute Sclerosing Panencephalitis	10.6%
268	Angioedemas, Hereditary	10.5%
269	Cranial nerve diseases	10.4%
270	Demyelinating Diseases	10.4%
271	Demyelination	10.4%
272	Neuromuscular Diseases	10.4%
273	Chronobiology Disorders	10.4%
274	Scrapie	10.4%
275	Kallmann Syndrome	10.3%
276	Ectodermal Dysplasia	10.3%
277	Aplasia Cutis Congenita	10.3%
278	Moyamoya Disease	10.3%
279	Torticollis	10.3%
280	Persistent Vegetative State	10.2%
281	Subarachnoid Hemorrhage, Traumatic	10%
282	Carotid Artery, Internal, Dissection	10%
283	Cerebral Palsy	10%
284	Epilepsies, Partial	10%
285	Epilepsy, Generalized	10%
286	Pseudotumor Cerebri	10%
287	Hypertensive Encephalopathy	10%
288	Simple Partial Seizures	10%
289	Epilepsy, Reflex	10%
290	Headache Disorders, Primary	10%
291	Headache Disorders, Secondary	10%
292	Medication overuse headache	10%
293	Cerebral Infarction	10%
294	Brain Stem Infarctions	10%
295	Central Nervous System Cysts	9.9%
296	Guillain-Barre Syndrome	9.8%
297	Classical Lissencephalies and Subcortical Band Heterotopias	9.8%
298	Trauma, Nervous System	9.8%
299	Kearns-Sayre syndrome	9.7%
300	Nervous System Neoplasms	9.7%
301	Neurologic Manifestations	9.7%
302	Neurotoxicity Syndromes	9.7%
303	Duane Retraction Syndrome	9.6%
304	Mitochondrial Myopathies	9.6%
305	Neuromyelitis Optica	9.6%
306	Cerebral Amyloid Angiopathy	9.5%
307	Movement Disorders	9.5%
308	Biliary cirrhosis	9.5%
309	Nesidioblastosis	9.4%
310	Bloom Syndrome	9.4%
311	Pituitary Diseases	9.3%
312	Tauopathies	9.2%
313	Carotid Artery Diseases	9.2%
314	Brain Ischemia	9.2%
315	Cerebrovascular accident	9.2%
316	Kluver-Bucy Syndrome	9.2%
317	Vasospasm, Intracranial	9.2%
318	Intracranial Arterial Diseases	9.2%
319	Basal Ganglia Diseases	9.2%
320	Sickle Cell Trait	9.1%
321	Sleep Wake Disorders	9.1%
322	Lateral Medullary Syndrome	9%
323	Autonomic Dysreflexia	8.9%
324	Complex Regional Pain Syndromes	8.9%
325	Arachnoiditis	8.9%
326	Aseptic Meningitis	8.9%
327	Syringomyelia	8.9%
328	Pneumorrhachis	8.9%
329	Progressive bulbar palsy	8.8%
330	Bulbar palsy	8.8%
331	Auditory Perceptual Disorders	8.8%
332	Welander Distal Myopathy	8.8%
333	Polycystic Kidney Diseases	8.7%
334	Meningitis, Cryptococcal	8.7%
335	Mobius Syndrome	8.7%
336	West Nile Fever	8.7%
337	Meningitis, Listeria	8.7%
338	Meningitis, Haemophilus	8.7%
339	Meningitis, Pneumococcal	8.7%
340	Adenomatous Polyposis Coli	8.6%
341	Tardive Dyskinesia	8.6%
342	Osteomalacia	8.6%
343	Intracranial Embolism and Thrombosis	8.5%
344	Brain Concussion	8.5%
345	Central Cord Syndrome	8.5%
346	Dural Arteriovenous Fistula	8.5%
347	Fatty Liver, Alcoholic	8.4%
348	Hepatitis, Alcoholic	8.4%
349	Liver Cirrhosis, Alcoholic	8.4%
350	Vertebral Artery Dissection	8.4%
351	Achlorhydria	8.3%
352	Retinal Dysplasia	8.3%
353	Primary Ciliary Dyskinesia	8.3%
354	Aniridia	8.3%
355	Peripheral Nerve Injuries	8.3%
356	Myasthenia Gravis	8.3%
357	Central Nervous System Fungal Infections	8.3%
358	Conus Medullaris Syndrome	8.3%
359	Spinal Cord Vascular Diseases	8.3%
360	Epidermolysis Bullosa	8.2%
361	Familial Mediterranean Fever	8.2%
362	Diffuse Axonal Injury	8.1%
363	Acute Chest Syndrome	8.1%
364	Brain Stem Neoplasms	8.1%
365	Celiac Disease	8.1%
366	Sprue, Tropical	8.1%
367	Steatorrhea	8.1%
368	Sprue	8.1%
369	Alice in Wonderland Syndrome	8%
370	Hydranencephaly	8%
371	Neural Tube Defects	8%
372	Tethered Cord Syndrome	8%
373	Iniencephaly	8%
374	Craniorachischisis	8%
375	Exencephaly	8%
376	Septo-Optic Dysplasia	8%
377	Cortical Dysplasia	8%
378	Malformations of Cortical Development	8%
379	Olfactory Nerve Injuries	8%
380	Paraneoplastic Encephalomyelitis	7.9%
381	Toxoplasmosis, Congenital	7.9%
382	Sleep Disorders, Circadian Rhythm	7.8%
383	Deformity	7.8%
384	Central Nervous System Bacterial Infections	7.7%
385	Botulism	7.7%
386	Peutz-Jeghers Syndrome	7.7%
387	Brain Contusion	7.6%
388	Causalgia	7.6%
389	Liver neoplasms	7.6%
390	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.5%
391	Nutrition Disorders	7.5%
392	Post-Traumatic Headache	7.5%
393	Tension Headache	7.5%
394	Epilepsy, Complex Partial	7.5%
395	Migraine Disorders	7.5%
396	Abdominal Migraine	7.5%
397	Status Migrainosus	7.5%
398	Cervicogenic Headache	7.5%
399	Facial Nerve Injuries	7.5%
400	AIDS Dementia Complex	7.5%
401	Giant Cell Arteritis	7.4%
402	Temporal Arteritis	7.4%
403	Liver Abscess, Amebic	7.4%
404	Acidosis	7.4%
405	Alkalosis	7.4%
406	Amyloidosis	7.4%
407	Calcinosis	7.4%
408	Hyperglycemia	7.4%
409	Hyperinsulinism	7.4%
410	Hyperkalemia	7.4%
411	Hypernatremia	7.4%
412	Hypoglycemia	7.4%
413	Hypokalemia	7.4%
414	Hyponatremia	7.4%
415	Xanthomatosis	7.4%
416	Hypophosphatemia	7.4%
417	Metabolic acidosis	7.4%
418	Dyslipidemias	7.4%
419	Iron Overload	7.4%
420	Xanthoma	7.4%
421	HIV Wasting Syndrome	7.4%
422	Tetany	7.4%
423	Diabetic Ketoacidosis	7.4%
424	Pseudoxanthoma Elasticum	7.3%
425	Fetal Diseases	7.2%
426	Anencephaly	7.2%
427	Renal Osteodystrophy	7.1%
428	Renal rickets	7.1%
429	Cutis Laxa	7.1%
430	Retinitis Pigmentosa	7.1%
431	Pigmentary retinopathy	7.1%
432	Porokeratosis	7.1%
433	Keratoderma, Palmoplantar	7.1%
434	Chronic granulomatous disease	7%
435	Myasthenia Gravis, Autoimmune, Experimental	7%
436	Empty Sella Syndrome	7%
437	Hyperpituitarism	7%
438	Hypopituitarism	7%
439	Hypophysitis	7%
440	Diabetes Mellitus	6.9%
441	HIV-Associated Lipodystrophy Syndrome	6.9%
442	Cerebral Arterial Diseases	6.9%
443	Vertebrobasilar Insufficiency	6.9%
444	Basilar Artery Stenosis	6.9%
445	Vertebral Artery Stenosis	6.9%
446	Intracranial Hemorrhage, Hypertensive	6.9%
447	Transient Cerebral Ischemia	6.9%
448	Dehydration	6.9%
449	Lipomatosis	6.9%
450	Water Intoxication	6.9%
451	Choroid Plexus Papilloma	6.8%
452	Osteoporosis	6.8%
453	Bone Demineralization, Pathologic	6.8%
454	Post-Traumatic Osteoporosis	6.8%
455	Horner Syndrome	6.8%
456	Meconium Aspiration Syndrome	6.7%
457	Brain Diseases	6.6%
458	Fatty Liver	6.6%
459	Hepatitis	6.6%
460	Portal Hypertension	6.6%
461	Liver Cirrhosis	6.6%
462	Focal Nodular Hyperplasia	6.6%
463	Hepatic Insufficiency	6.6%
464	Steatohepatitis	6.6%
465	Thrombasthenia	6.6%
466	Antithrombin III Deficiency	6.6%
467	Protein C Deficiency	6.6%
468	Afibrinogenemia	6.6%
469	Basal Cell Nevus Syndrome	6.6%
470	Factor VII Deficiency	6.6%
471	Factor X Deficiency	6.6%
472	Factor XII Deficiency	6.6%
473	Hemophilia A	6.6%
474	Activated Protein C Resistance	6.6%
475	Factor II deficiency	6.6%
476	Factor VIII Deficiency	6.6%
477	Factor V deficiency	6.6%
478	Factor XI Deficiency	6.6%
479	Hypoprothrombinemias	6.6%
480	Anemia, Diamond-Blackfan	6.5%
481	Carotid Stenosis	6.4%
482	Intracranial Aneurysm	6.4%
483	Intracranial Arteriosclerosis	6.4%
484	Cerebral Atherosclerosis	6.4%
485	Subarachnoid Hemorrhage	6.4%
486	Cerebral Arteriosclerosis	6.4%
487	Cerebral Hemorrhage	6.4%
488	Hyperkeratosis, Epidermolytic	6.4%
489	Cerebral Thrombosis	6.4%
490	Intracranial Embolism	6.4%
491	Intracranial Thrombosis	6.4%
492	Jet Lag Syndrome	6.4%
493	Glycosuria	6.3%
494	Multiple Sclerosis	6.3%
495	Cluster Headache	6.3%
496	Migraine with Aura	6.3%
497	Familial Hemiplegic Migraine	6.3%
498	Chronic Paroxysmal Hemicrania	6.3%
499	SUNCT Syndrome	6.3%
500	Paroxysmal Hemicrania	6.3%
501	Multiple Endocrine Neoplasia	6.3%
502	Hematoma, Subdural	6.2%
503	Hematoma, Epidural, Cranial	6.2%
504	Hepatitis B, Chronic	6.2%
505	Hepatitis C, Chronic	6.2%
506	Liver Diseases, Parasitic	6.2%
507	Congenital Hypothyroidism	6.2%
508	Dermatitis, Atopic	6.2%
509	Hepatic Veno-Occlusive Disease	6.1%
510	Peliosis Hepatis	6.1%
511	Hepatopulmonary Syndrome	6.1%
512	Zollinger-Ellison syndrome	6.1%
513	Hepatomegaly	6.1%
514	Polycystic Kidney, Autosomal Dominant	6.1%
515	Hepatic Vein Thrombosis	6.1%
516	Liver Abscess	6.1%
517	Budd-Chiari Syndrome	6.1%
518	Esophageal and Gastric Varices	6.1%
519	Congenital nystagmus	6%
520	Carotid Artery Thrombosis	6%
521	Ophthalmoplegia	5.9%
522	External Ophthalmoplegia	5.9%
523	Dysautonomia	5.9%
524	Vagus Nerve Disorder	5.9%
525	Glossopharyngeal Neuralgia	5.9%
526	Abducens Nerve Diseases	5.9%
527	Heavy Metal Poisoning, Nervous System	5.9%
528	Neuromuscular Junction Diseases	5.9%
529	Trochlear Nerve Diseases	5.9%
530	Peripheral Nervous System Diseases	5.9%
531	Necrobiosis Lipoidica Diabeticorum	5.9%
532	Behcet Syndrome	5.8%
533	Reflex Sympathetic Dystrophy	5.8%
534	Nocturnal Myoclonus Syndrome	5.8%
535	Hyperprolactinemia	5.8%
536	Subclavian Steal Syndrome	5.8%
537	Pick Disease of the Brain	5.8%
538	Xeroderma	5.7%
539	Chemical and Drug Induced Liver Injury	5.7%
540	Spinal Cord Ischemia	5.7%
541	Esophageal Atresia	5.7%
542	Intestinal Atresia	5.7%
543	Hepatorenal Syndrome	5.7%
544	Tuberculosis, Central Nervous System	5.6%
545	Vocal Cord Paralysis	5.6%
546	Optic Nerve Glioma	5.6%
547	Myopathy	5.5%
548	Optic Neuropathy	5.5%
549	Facial Nerve Diseases	5.5%
550	Craniocerebral Trauma	5.5%
551	Parasomnia	5.5%
552	Dyssomnias	5.5%
553	Vestibulocochlear Nerve Diseases	5.5%
554	Decerebrate State	5.5%
555	Hemiparesis	5.5%
556	Meningism	5.5%
557	Paresis	5.5%
558	Seizures	5.5%
559	Sensation Disorders	5.5%
560	Central Nervous System Neoplasms	5.5%
561	Complex partial seizures	5.5%
562	Monoparesis	5.5%
563	Neurogenic Inflammation	5.5%
564	Gait Disorders, Neurologic	5.5%
565	Neuromuscular Manifestations	5.5%
566	Sweating, Gustatory	5.4%
567	Auriculotemporal Syndrome	5.4%
568	Turner Syndrome	5.4%
569	Acromegaly	5.4%
570	Hematoma, Subdural, Intracranial	5.4%
571	Hematoma, Subdural, Chronic	5.4%
572	Hematoma, Subdural, Acute	5.4%
573	Acrodynia	5.4%
574	Sinus Thrombosis, Intracranial	5.3%
575	Choledochal Cyst	5.3%
576	Waterhouse-Friderichsen Syndrome	5.3%
577	Neuroaspergillosis	5.3%
578	Hepatocellular Adenoma	5.2%
579	Alcohol Withdrawal Seizures	5.2%
580	Nephroblastoma	5.2%
581	Meningomyelocele	5.2%
582	Spina Bifida	5.2%
583	Pupil Disorders	5.1%
584	Neurobehavioral Manifestations	5.1%
585	Uveomeningoencephalitic Syndrome	5.1%
586	Sturge-Weber Syndrome	5.1%
587	Vertigo	5.1%
588	Alcohol-Induced Disorders, Nervous System	5.1%
589	Pseudorabies	5%
590	Cerebrospinal Fluid Otorrhea	5%
591	Cerebrospinal Fluid Rhinorrhea	5%
592	Neuritis, Autoimmune, Experimental	5%
593	Gait Ataxia	5%
594	Klinefelter Syndrome	5%
595	Liver Neoplasms, Experimental	4.9%
596	Hepatitis, Chronic	4.9%
597	Liver Failure	4.9%
598	Non-alcoholic Fatty Liver Disease	4.9%
599	Chronic active hepatitis	4.9%
600	Acidosis, Lactic	4.9%
601	Calciphylaxis	4.9%
602	Hemosiderosis	4.9%
603	Ketosis	4.9%
604	Ketonuria	4.9%
605	Ketoacidosis	4.9%
606	Ketonemia	4.9%
607	Vascular calcification	4.9%
608	Papillon-Lefevre Disease	4.9%
609	Neurosyphilis	4.9%
610	Hydrops Fetalis	4.8%
611	Cavernous Sinus Thrombosis	4.8%
612	Sagittal Sinus Thrombosis	4.8%
613	Meningocele	4.8%
614	Encephalocele	4.8%
615	Microcephaly	4.8%
616	Macrocephaly	4.8%
617	Colorectal Neoplasms	4.8%
618	Voice Disorders	4.8%
619	Voice Disturbance	4.8%
620	Brachial Plexus Neuritis	4.8%
621	Neuralgic Amyotrophy	4.8%
622	Proctocolitis	4.8%
623	Akathisia	4.7%
624	Restlessness	4.7%
625	Psychomotor Agitation	4.7%
626	Prolactinoma	4.7%
627	Growth Hormone-Secreting Pituitary Adenoma	4.7%
628	Coma, Post-Head Injury	4.7%
629	Hepatitis, Animal	4.6%
630	Hepatitis, Viral, Human	4.6%
631	Lyme Neuroborreliosis	4.6%
632	Anus, Imperforate	4.6%
633	Anorectal Malformations	4.6%
634	Liver Cirrhosis, Experimental	4.6%
635	Acidosis, Respiratory	4.5%
636	Adiposis Dolorosa	4.5%
637	Alkalosis, Respiratory	4.5%
638	Insulin Resistance	4.5%
639	Osteoporosis, Postmenopausal	4.5%
640	Nelson Syndrome	4.5%
641	Porencephaly	4.5%
642	Multiple Sclerosis, Chronic Progressive	4.4%
643	Multiple Sclerosis, Relapsing-Remitting	4.4%
644	Reflex, Abnormal	4.4%
645	Hyporeflexia	4.4%
646	Hyperreflexia	4.4%
647	Acoustic Neuroma	4.4%
648	Abdominal Cramps	4.4%
649	Abnormalities, Drug-Induced	4.4%
650	Amniotic Band Syndrome	4.4%
651	Asphyxia Neonatorum	4.4%
652	Infant, Premature, Diseases	4.4%
653	Situs Inversus	4.4%
654	Infantile Colic	4.4%
655	Anterior Spinal Artery Syndrome	4.4%
656	CREST Syndrome	4.3%
657	Multiple Endocrine Neoplasia Type 1	4.3%
658	Gait Apraxia	4.3%
659	Tarsal Tunnel Syndrome	4.3%
660	Cauda Equina Syndrome	4.3%
661	POEMS Syndrome	4.3%
662	Gestational Diabetes	4.3%
663	Latent Autoimmune Diabetes in Adults	4.3%
664	Fascioliasis	4.3%
665	Diabetes Mellitus, Experimental	4.2%
666	Echinococcosis, Hepatic	4.2%
667	Chemical and Drug Induced Liver Injury, Chronic	4.2%
668	Nephrocalcinosis	4.2%
669	Eye Abnormalities	4.1%
670	Cardiovascular Abnormalities	4.1%
671	Child Nutrition Disorders	4.1%
672	Hypervitaminosis A	4.1%
673	Infant Nutrition Disorders	4.1%
674	Malnutrition	4.1%
675	Malaria, Cerebral	4.1%
676	Liver Failure, Acute	4.1%
677	End Stage Liver Disease	4.1%
678	Anus Neoplasms	4.1%
679	Sigmoid Neoplasms	4.1%
680	Skin Abnormalities	4.1%
681	Lymphatic Abnormalities	4.1%
682	Congenital Microtia	4.1%
683	Neurocysticercosis	4.1%
684	Cecal Neoplasms	4.1%
685	Duodenal Neoplasms	4.1%
686	Anemia, Neonatal	4.1%
687	Persistent Fetal Circulation Syndrome	4.1%
688	Congenital diaphragmatic hernia	4.1%
689	Umbilical hernia	4.1%
690	Carpal Tunnel Syndrome	4%
691	neurofibroma	4%
692	Sciatica	4%
693	Bile Duct Neoplasms	3.9%
694	gallbladder neoplasm	3.9%
695	Intestinal Neoplasms	3.9%
696	Stomach Neoplasms	3.9%
697	Primary amyloidosis	3.9%
698	Urogenital Abnormalities	3.9%
699	Neonatal Abstinence Syndrome	3.8%
700	Autoimmune hepatitis	3.8%
701	Gastrointestinal Neoplasms	3.8%
702	Pancreatic Fistula	3.8%
703	Fetal Growth Retardation	3.8%
704	Fetal Hypoxia	3.8%
705	Fetal Alcohol Spectrum Disorders	3.8%
706	Dermal Sinus	3.8%
707	Spina Bifida Cystica	3.8%
708	Spina Bifida Occulta	3.8%
709	Lissencephaly	3.8%
710	Polymicrogyria	3.8%
711	Pachygyria	3.8%
712	Schizencephaly	3.8%
713	Periventricular Nodular Heterotopia	3.8%
714	Syphilis, Congenital	3.8%
715	Maxillofacial Abnormalities	3.7%
716	Denys-Drash Syndrome	3.7%
717	Dextrocardia	3.7%
718	Esophageal Neoplasms	3.7%
719	Neuritis	3.7%
720	Polyneuritis	3.7%
721	Radiculitis	3.7%
722	Polyneuropathy	3.7%
723	Mononeuritis	3.7%
724	Mononeuropathies	3.7%
725	Brachial Plexus Neuropathies	3.7%
726	Radiculopathy	3.7%
727	Mononeuropathy Multiplex	3.7%
728	Nerve Root Compression	3.7%
729	Massive Hepatic Necrosis	3.7%
730	Hypercholesterolemia	3.7%
731	Hyperlipoproteinemias	3.7%
732	Hypertriglyceridemia	3.7%
733	Appendiceal Neoplasms	3.6%
734	Colonic Neoplasms	3.6%
735	Rectal Neoplasms	3.6%
736	Hepatitis, Viral, Animal	3.6%
737	Hepatitis E	3.6%
738	Peritoneal Neoplasms	3.5%
739	Hepatitis B	3.5%
740	Hepatitis C	3.5%
741	Hepatitis A	3.5%
742	Chorioamnionitis	3.5%
743	Duodenitis	3.5%
744	Ileitis	3.5%
745	Erosive Duodenitis	3.5%
746	Cubital Tunnel Syndrome	3.5%
747	Rectal Fistula	3.5%
748	Anal Fistula	3.5%
749	Myositis	3.4%
750	Optic Atrophy	3.4%
751	Optic Neuritis	3.4%
752	Papilledema	3.4%
753	Strabismus	3.4%
754	Tolosa-Hunt Syndrome	3.4%
755	Isaacs syndrome	3.4%
756	Arsenic Poisoning	3.4%
757	Myotonic Disorders	3.4%
758	Diabetic Neuropathies	3.4%
759	Facial Injuries	3.4%
760	Facial Neuralgia	3.4%
761	Diabetic Amyotrophy	3.4%
762	Diabetic Autonomic Neuropathy	3.4%
763	Sleep Talking	3.4%
764	Manganese Poisoning	3.4%
765	Sleep Disorders, Intrinsic	3.4%
766	Orthostatic intolerance	3.4%
767	Anosmia	3.4%
768	Ataxia	3.4%
769	Athetosis	3.4%
770	Catalepsy	3.4%
771	Dystonia	3.4%
772	Hemiplegia	3.4%
773	Locked-In Syndrome	3.4%
774	Meningeal Neoplasms	3.4%
775	Muscle Hypertonia	3.4%
776	Muscle hypotonia	3.4%
777	Myoclonus	3.4%
778	Myotonia	3.4%
779	Neuralgia	3.4%
780	Paraplegia	3.4%
781	Pseudobulbar Palsy	3.4%
782	Quadriplegia	3.4%
783	Spasm	3.4%
784	Spastic Paraplegia	3.4%
785	Status Epilepticus	3.4%
786	Taste Disorders	3.4%
787	Tremor	3.4%
788	Monoplegia	3.4%
789	Hypokinesia	3.4%
790	Paraparesis	3.4%
791	Bradykinesia	3.4%
792	Waxy flexibility	3.4%
793	Action Tremor	3.4%
794	Resting Tremor	3.4%
795	Dysosmia	3.4%
796	Quadriparesis	3.4%
797	Mercury Poisoning, Nervous System	3.4%
798	Olfaction Disorders	3.4%
799	Myokymia	3.4%
800	Lead Poisoning, Nervous System	3.4%
801	Vestibular Neuronitis	3.4%
802	Somatosensory Disorders	3.4%
803	Neuropathic pain	3.4%
804	Hyperkinesia	3.4%
805	Intention tremor	3.4%
806	Acrocephalosyndactylia	3.4%
807	Biliary Tract Diseases	3.3%
808	Gastrointestinal Diseases	3.3%
809	Pancreatic Diseases	3.3%
810	Pancreatic Neoplasm	3.3%
811	Scimitar Syndrome	3.3%
812	Mesenteric vascular insufficiency	3.3%
813	Mesenteric Vascular Occlusion	3.3%
814	Intestinal Fistula	3.3%
815	Enterocutaneous Fistula	3.3%
816	Abnormalities, Radiation-Induced	3.3%
817	Hand-Arm Vibration Syndrome	3.2%
818	Vision Disorders	3.2%
819	Metamorphopsia	3.2%
820	Visual Impairment	3.2%
821	Fibromyalgia	3.2%
822	Optic Neuropathy, Ischemic	3.2%
823	Anterior Ischemic Optic Neuropathy	3.2%
824	Medial Tibial Stress Syndrome	3.2%
825	Facial Hemiatrophy	3.2%
826	Melkersson-Rosenthal Syndrome	3.2%
827	Anisocoria	3.2%
828	Confusion	3.2%
829	Facial paralysis	3.2%
830	Lethargy	3.2%
831	Memory Disorders	3.2%
832	Muscle Cramp	3.2%
833	Perceptual Disorders	3.2%
834	Psychomotor Disorders	3.2%
835	Tonic Pupil	3.2%
836	Eosinophilia-Myalgia Syndrome	3.2%
837	Anhedonia	3.2%
838	Disorientation	3.2%
839	Facial Paresis	3.2%
840	Memory Loss	3.2%
841	Hemisensory Neglect	3.2%
842	Dysacusis	3.2%
843	Sleep Bruxism	3.2%
844	Muscular Atrophy	3.2%
845	Respiratory Paralysis	3.2%
846	Pouchitis	3.1%
847	Digestive System Neoplasms	3.1%
848	Ophthalmia Neonatorum	3.1%
849	Alexia	3%
850	Dyslexia	3%
851	Dysentery	3%
852	Enteritis	3%
853	Enterocolitis	3%
854	Esophagitis	3%
855	Gastritis	3%
856	Inflammatory Bowel Diseases	3%
857	Cholecystolithiasis	3%
858	Consciousness Disorders	3%
859	Mental Retardation	3%
860	Muscle Weakness	3%
861	Depressed Level of Consciousness	3%
862	Mental deficiency	3%
863	Intellectual Disability	3%
864	Bell Palsy	3%
865	Catatonia	3%
866	Herpes Zoster Oticus	3%
867	Aphonia	3%
868	Sleep Deprivation	3%
869	Dysphonia	3%
870	Craniosynostosis	2.9%
871	Syndactyly	2.9%
872	Brachycephaly	2.9%
873	Neurofibrosarcoma	2.8%
874	Cleft Palate	2.8%
875	Gastrointestinal Stromal Tumors	2.8%
876	Colitis	2.8%
877	Duodenogastric Reflux	2.8%
878	Peptic Ulcer	2.8%
879	Proctitis	2.8%
880	Choledocholithiasis	2.8%
881	Myalgia	2.8%
882	Prune Belly Syndrome	2.7%
883	Twins, Conjoined	2.7%
884	Waardenburg Syndrome	2.7%
885	Noonan Syndrome	2.7%
886	Rift Valley Fever	2.6%
887	Hoarseness	2.6%
888	Alcohol Withdrawal Delirium	2.6%
889	Sciatic Neuropathy	2.6%
890	Ulnar Neuropathies	2.6%
891	Lesion of Sciatic Nerve	2.6%
892	Ulnar Neuritis	2.6%
893	Radial nerve compression	2.6%
894	Radial Tunnel Syndrome	2.6%
895	Peroneal Neuropathies	2.6%
896	Radial Neuropathy	2.6%
897	Median Neuropathy	2.6%
898	Sciatic Nerve Palsy	2.6%
899	Femoral Neuropathy	2.6%
900	Tibial Neuropathy	2.6%
901	Ulnar Nerve Palsy	2.6%
902	Postural Orthostatic Tachycardia Syndrome	2.6%
903	Radial nerve palsy	2.6%
904	Appendicitis	2.6%
905	Anophthalmos	2.5%
906	Microphthalmos	2.5%
907	Paralysis, Obstetric	2.5%
908	Retinopathy of Prematurity	2.5%
909	Limb Deformities, Congenital	2.5%
910	Craniofacial Abnormalities	2.5%
911	Bronchopulmonary Dysplasia	2.5%
912	Crohn Disease	2.5%
913	Duodenal Obstruction	2.5%
914	Enterocolitis, Neutropenic	2.5%
915	Necrotizing Enterocolitis	2.5%
916	Deficiency Diseases	2.5%
917	Starvation	2.5%
918	Refeeding Syndrome	2.5%
919	Jaw Abnormalities	2.4%
920	Thoracic Outlet Syndrome	2.4%
921	Esotropia	2.4%
922	Exotropia	2.4%
923	Hypotension, Orthostatic	2.4%
924	Sleep Apnea Syndromes	2.4%
925	Polymyositis	2.4%
926	Post-Exercise Hypotension	2.4%
927	Disorders of Excessive Somnolence	2.4%
928	Sleep Initiation and Maintenance Disorders	2.4%
929	Night Terrors	2.4%
930	Somnambulism	2.4%
931	Trigeminal Nerve Disorder	2.4%
932	Transient Insomnia	2.4%
933	Sleep Paralysis	2.4%
934	Chronic Insomnia	2.4%
935	REM Sleep Behavior Disorder	2.4%
936	Hypersomnia	2.4%
937	Duodenal Ulcer	2.4%
938	Dysgeusia	2.4%
939	Formication	2.4%
940	Hyperalgesia	2.4%
941	Hyperesthesia	2.4%
942	Hypesthesia	2.4%
943	Language Disorders	2.4%
944	Numbness	2.4%
945	Paresthesia	2.4%
946	Peptic Ulcer Perforation	2.4%
947	Paraparesis, Spastic	2.4%
948	Gastric ulcer	2.4%
949	Trismus	2.4%
950	Epilepsia Partialis Continua	2.4%
951	Hypogeusia	2.4%
952	Meningeal Carcinomatosis	2.4%
953	Brown-Sequard Syndrome	2.4%
954	Lockjaw	2.4%
955	Allodynia	2.4%
956	Lead Poisoning, Nervous System, Childhood	2.4%
957	Lead Poisoning, Nervous System, Adult	2.4%
958	Ageusia	2.4%
959	Blepharophimosis	2.4%
960	Laryngostenosis	2.4%
961	Mouth Abnormalities	2.4%
962	Respiratory Distress Syndrome, Newborn	2.4%
963	Horseshoe Kidney	2.4%
964	Pectus excavatum	2.4%
965	Klippel-Feil Syndrome	2.4%
966	Gastroschisis	2.4%
967	Synostosis	2.4%
968	Acrodermatitis	2.4%
969	Lymphangiectasis, Intestinal	2.4%
970	Gianotti-Crosti Syndrome	2.4%
971	Enterocolitis, Pseudomembranous	2.3%
972	pseudomembranous colitis	2.3%
973	Dysentery, Bacillary	2.3%
974	Eye Injuries	2.3%
975	Orbital Myositis	2.2%
976	Poland Syndrome	2.2%
977	Diplopia	2.2%
978	Muscle Rigidity	2.2%
979	Muscle Spasticity	2.2%
980	Scotoma	2.2%
981	Photophobia	2.2%
982	Cogwheel Rigidity	2.2%
983	Colitis, Ischemic	2.2%
984	Hemifacial Spasm	2.2%
985	Amaurosis	2.2%
986	Blindness	2.2%
987	Nuchal Rigidity	2.2%
988	Pyomyositis	2.2%
989	Arthrogryposis	2.2%
990	Choanal Atresia	2.2%
991	Tracheobronchomegaly	2.2%
992	Laryngocele	2.2%
993	Agnosia	2.2%
994	Apraxias	2.2%
995	Hallucinations	2.2%
996	Hemianopsia	2.2%
997	Hyperacusis	2.2%
998	Tinnitus	2.2%
999	Visual Agnosia	2.2%
1000	Anosognosia	2.2%
1001	Wernicke-Korsakoff Syndrome	2.2%
1002	Phonophobia	2.2%
1003	Hearing Loss	2.2%
1004	Hermaphroditism	2.2%
1005	Disorders of Sex Development	2.2%
1006	Sarcopenia	2.2%
1007	Cryptorchidism	2.2%
1008	Hypospadias	2.2%
1009	Bile Duct Diseases	2.2%
1010	Cholelithiasis	2.2%
1011	Chylous Ascites	2.2%
1012	Esophageal Diseases	2.2%
1013	Gastroenteritis	2.2%
1014	Intestinal Diseases	2.2%
1015	Pancreatic Insufficiency	2.2%
1016	Pancreatitis	2.2%
1017	Pneumoperitoneum	2.2%
1018	Stomach Diseases	2.2%
1019	Colonic Pseudo-Obstruction	2.2%
1020	Carcinoma, Pancreatic Ductal	2.2%
1021	Laryngomalacia	2.1%
1022	Amnesia	2.1%
1023	Delirium	2.1%
1024	Dissociative Amnesia	2.1%
1025	Color blindness	2.1%
1026	Global Amnesia	2.1%
1027	Pectus carinatum	2.1%
1028	Meningioma	2.1%
1029	Bladder Exstrophy	2.1%
1030	Epispadias	2.1%
1031	Multicystic Dysplastic Kidney	2.1%
1032	Polyradiculopathy	2%
1033	Pancreatic Cyst	2%
1034	Gastrointestinal Hemorrhage	2%
1035	Hemoperitoneum	2%
1036	Mesenteric Panniculitis	2%
1037	Panniculitis, Peritoneal	2%
1038	Peritonitis	2%
1039	Peritoneal Fibrosis	2%
1040	Encapsulating Peritoneal Sclerosis	2%
1041	Biliary Fistula	2%
1042	Gastric Fistula	2%
1043	Tuberculosis, Gastrointestinal	2%
1044	Micrognathism	2%
1045	Pierre Robin Syndrome	2%
1046	Obesity	2%
1047	Phantom pain	1.9%
1048	Phantom Limb Pain	1.9%
1049	insulinoma	1.9%
1050	Gastrinoma	1.9%
1051	Glucagonoma	1.9%
1052	Sleep Apnea, Obstructive	1.9%
1053	Sleep Apnea, Central	1.9%
1054	Narcolepsy	1.9%
1055	Trigeminal Neuralgia	1.9%
1056	Kleine-Levin Syndrome	1.9%
1057	Agraphia	1.9%
1058	Anomia	1.9%
1059	Cluttering	1.9%
1060	Language Development Disorders	1.9%
1061	Speech Disorders	1.9%
1062	Syncope	1.9%
1063	Stupor	1.9%
1064	Dysgraphia	1.9%
1065	Presyncope	1.9%
1066	Dyslalia	1.9%
1067	Hyperandrogenism	1.9%
1068	Retrognathia	1.9%
1069	Vipoma	1.8%
1070	Amelia	1.8%
1071	Arachnodactyly	1.8%
1072	Ectopia Cordis	1.8%
1073	Ectromelia	1.8%
1074	Hemimelia	1.8%
1075	Phocomelia	1.8%
1076	Sirenomelia	1.8%
1077	Polydactyly	1.8%
1078	Brachydactyly	1.8%
1079	Plagiocephaly	1.8%
1080	Lower Extremity Deformities, Congenital	1.8%
1081	Upper Extremity Deformities, Congenital	1.8%
1082	Single umbilical artery	1.8%
1083	Prognathism	1.8%
1084	Eye Burns	1.8%
1085	Amaurosis Fugax	1.7%
1086	Blindness, Cortical	1.7%
1087	Dyscalculia	1.7%
1088	Deafness	1.7%
1089	Hearing Loss, Sudden	1.7%
1090	Gerstmann Syndrome	1.7%
1091	Hearing Loss, Bilateral	1.7%
1092	Hearing Loss, High-Frequency	1.7%
1093	Hearing Loss, Mixed Conductive-Sensorineural	1.7%
1094	Prosopagnosia	1.7%
1095	Apraxia, Ideomotor	1.7%
1096	Charles Bonnet Syndrome	1.7%
1097	Hearing Loss, Unilateral	1.7%
1098	Complete Hearing Loss	1.7%
1099	Alien Hand Syndrome	1.7%
1100	Deaf Mutism	1.7%
1101	Dermatomyositis	1.7%
1102	Corneal Scar	1.7%
1103	Cecal Diseases	1.6%
1104	Cholangitis	1.6%
1105	Cholecystitis	1.6%
1106	Cholestasis	1.6%
1107	Colonic Diseases	1.6%
1108	Common Bile Duct Diseases	1.6%
1109	Esophageal Stenosis	1.6%
1110	Ileal Diseases	1.6%
1111	Intestinal Obstruction	1.6%
1112	Intestinal Perforation	1.6%
1113	Jejunal Diseases	1.6%
1114	Pneumatosis Cystoides Intestinalis	1.6%
1115	Rectal Diseases	1.6%
1116	Gastric Dilatation	1.6%
1117	Pancreatitis, Chronic	1.6%
1118	Gastric outlet obstruction	1.6%
1119	Cronkhite-Canada Syndrome	1.6%
1120	Intestinal Polyposis	1.6%
1121	Aortic coarctation	1.6%
1122	Cor Triatriatum	1.6%
1123	Coronary Vessel Anomalies	1.6%
1124	Dental Enamel Hypoplasia	1.6%
1125	Patent ductus arteriosus	1.6%
1126	Ebstein Anomaly	1.6%
1127	Heart Septal Defects	1.6%
1128	Hyaline Membrane Disease	1.6%
1129	Hypodontia	1.6%
1130	Macrostomia	1.6%
1131	Microstomia	1.6%
1132	Tetralogy of Fallot	1.6%
1133	Transposition of Great Vessels	1.6%
1134	Hypoplastic Left Heart Syndrome	1.6%
1135	May-Thurner Syndrome	1.6%
1136	Craniofacial Dysostosis	1.6%
1137	Kwashiorkor	1.6%
1138	Magnesium Deficiency	1.6%
1139	Potassium Deficiency	1.6%
1140	Protein Deficiency	1.6%
1141	Avitaminosis	1.6%
1142	Wolff-Parkinson-White Syndrome	1.6%
1143	Retrograde amnesia	1.6%
1144	Amnesia, Anterograde	1.6%
1145	Cataplexy	1.6%
1146	Aphasia	1.6%
1147	Articulation Disorders	1.6%
1148	Echolalia	1.6%
1149	Stuttering	1.6%
1150	Dysphasia	1.6%
1151	Esophageal Perforation	1.5%
1152	Intestinal Diseases, Parasitic	1.5%
1153	Long QT Syndrome	1.5%
1154	Platybasia	1.5%
1155	Tricuspid Atresia	1.5%
1156	Arrhythmogenic Right Ventricular Dysplasia	1.5%
1157	Gonadal Dysgenesis	1.5%
1158	Bronchomalacia	1.5%
1159	Adrenogenital Syndrome	1.5%
1160	Tracheomalacia	1.5%
1161	Ovotesticular Disorders of Sex Development	1.5%
1162	Barrett Esophagus	1.5%
1163	Deglutition Disorders	1.5%
1164	Mutism	1.5%
1165	Selective Mutism	1.5%
1166	Pancreatic Pseudocyst	1.5%
1167	Gastric Antral Vascular Ectasia	1.5%
1168	Peptic Ulcer Hemorrhage	1.5%
1169	Gastroparesis	1.5%
1170	Pancreatitis, Alcoholic	1.5%
1171	Dysarthria	1.5%
1172	Corneal Perforation	1.4%
1173	Melena	1.4%
1174	Hematemesis	1.4%
1175	Alexia, Pure	1.4%
1176	Obesity, Abdominal	1.4%
1177	Cholestasis, Extrahepatic	1.4%
1178	Biliary Dyskinesia	1.4%
1179	Cholangitis, Sclerosing	1.4%
1180	Colonic Diseases, Functional	1.4%
1181	Esophageal motility disorders	1.4%
1182	Fecal Incontinence	1.4%
1183	Fecal Impaction	1.4%
1184	Intussusception	1.4%
1185	Mallory-Weiss Syndrome	1.4%
1186	Megacolon	1.4%
1187	Pyloric Stenosis	1.4%
1188	Acalculous Cholecystitis	1.4%
1189	Ileus	1.4%
1190	Meconium ileus	1.4%
1191	Pediatric Obesity	1.3%
1192	Aortopulmonary Septal Defect	1.3%
1193	Double Outlet Right Ventricle	1.3%
1194	Endocardial Cushion Defects	1.3%
1195	Myocardial bridging	1.3%
1196	Aorticopulmonary Septal Defect	1.3%
1197	Hemorrhoids	1.3%
1198	Afferent Loop Syndrome	1.3%
1199	Short Bowel Syndrome	1.3%
1200	Rectocele	1.3%
1201	Diverticulitis	1.3%
1202	Dumping Syndrome	1.3%
1203	Rectal Prolapse	1.3%
1204	Ascorbic Acid Deficiency	1.2%
1205	Esophageal Achalasia	1.2%
1206	Anal Fissure	1.2%
1207	Intestinal Pseudo-Obstruction	1.2%
1208	Irritable Bowel Syndrome	1.2%
1209	Superior Mesenteric Artery Syndrome	1.2%
1210	Vitamin A Deficiency	1.2%
1211	Vitamin D Deficiency	1.2%
1212	Vitamin E Deficiency	1.2%
1213	Marasmus	1.2%
1214	Emphysematous Cholecystitis	1.2%
1215	Neurogenic Bowel	1.2%
1216	Sphincter of Oddi Dysfunction	1.2%
1217	Anal Ulcer	1.2%
1218	Mandibulofacial Dysostosis	1.2%
1219	Romano-Ward Syndrome	1.2%
1220	Giardiasis	1.2%
1221	Diverticulum	1.2%
1222	Diverticulosis	1.2%
1223	Pruritus Ani	1.1%
1224	Truncus Arteriosus, Persistent	1.1%
1225	Goldenhar Syndrome	1.1%
1226	Laryngopharyngeal Reflux	1.1%
1227	Arteriovenous fistula	1.1%
1228	Vitamin K Deficiency	1.1%
1229	Talipes	1%
1230	Folic Acid Deficiency	1%
1231	Pellagra	1%
1232	Thiamine Deficiency	1%
1233	Vitamin B 12 Deficiency	1%
1234	Vitamin B 6 Deficiency	1%
1235	Pyridoxine Deficiency	1%
1236	Cryptosporidiosis	1%
1237	Congenital clubfoot	0.9%
1238	Vertical Talus	0.9%
1239	Beriberi	0.9%
1240	Scurvy	0.9%
1241	Anemia, Pernicious	0.8%

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