MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Protein Deficiency

(UMLS:C0033626)

Definition:: A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406)
UMLS ID:: C0033626
MeSH ID:: D011488

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.708

Synonym(s)

Protein Deficiency

Protein deficiency

deficiencies protein

deficiency protein

deficiency; protein

protein deficiencies

protein deficiency

protein; deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Lenalidomide	FAERS: 3		US FAERS
2	Crizotinib	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Dimethyl Fumarate	FAERS: 1		US FAERS
4	Duloxetine Hydrochloride	FAERS: 1		US FAERS
5	Everolimus	FAERS: 1		US FAERS
6	Liraglutide	FAERS: 1		US FAERS
7	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
8	Octreotide	FAERS: 1		US FAERS
9	PCI 32765	FAERS: 1		US FAERS
10	Pregabalin	FAERS: 1		US FAERS
11	Rivaroxaban	FAERS: 1		US FAERS
12	Rosuvastatin Calcium	FAERS: 1		US FAERS
13	Thyroxine	FAERS: 1		US FAERS
14	niraparib	FAERS: 1		US FAERS
15	regorafenib	FAERS: 1		US FAERS
16	teduglutide	FAERS: 1		US FAERS
17	telotristat ethyl	FAERS: 1		US FAERS
18	Acetylcysteine		16214328	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Magnesium Deficiency	48.4%
2	Potassium Deficiency	48.4%
3	Avitaminosis	48.4%
4	Ascorbic Acid Deficiency	36%
5	Vitamin A Deficiency	36%
6	Vitamin D Deficiency	36%
7	Vitamin E Deficiency	36%
8	Starvation	34.4%
9	Refeeding Syndrome	34.4%
10	Folic Acid Deficiency	29.9%
11	Pellagra	29.9%
12	Thiamine Deficiency	29.9%
13	Vitamin B 12 Deficiency	29.9%
14	Vitamin B 6 Deficiency	29.9%
15	Pyridoxine Deficiency	29.9%
16	Beriberi	26.8%
17	Child Nutrition Disorders	25.4%
18	Hypervitaminosis A	25.4%
19	Infant Nutrition Disorders	25.4%
20	Wasting Syndrome	23%
21	Kwashiorkor	22.6%
22	Vitamin K Deficiency	18.4%
23	Anemia, Pernicious	17.9%
24	Metabolic Diseases	16.4%
25	Rickets	16.2%
26	Hyperhomocysteinemia	15.3%
27	Scurvy	15.2%
28	Osteomalacia	13.4%
29	Wernicke Encephalopathy	10.8%
30	Subacute Combined Degeneration	9.4%
31	Acid-Base Imbalance	8.5%
32	Calcium Metabolism Disorders	8.5%
33	Iron Metabolism Disorders	8.5%
34	Phosphorus Metabolism Disorders	8.5%
35	Water-Electrolyte Imbalance	8.5%
36	Lipid Metabolism Disorders	8.5%
37	Mitochondrial Diseases	8.5%
38	Glucose Metabolism Disorders	8.5%
39	Renal Osteodystrophy	8.4%
40	Renal rickets	8.4%
41	Hypercalcemia	6.6%
42	Hypocalcemia	6.6%
43	Milk-Alkali Syndrome	6.6%
44	HIV Wasting Syndrome	6.5%
45	Familial Hypophosphatemic Rickets	6.1%
46	Obesity	5.8%
47	Osteopenia	5.7%
48	Brain Diseases, Metabolic	5.6%
49	Lipodystrophy	5%
50	Acidosis	4.9%
51	Alkalosis	4.9%
52	Amyloidosis	4.9%
53	Calcinosis	4.9%
54	Hyperglycemia	4.9%
55	Hyperinsulinism	4.9%
56	Hyperkalemia	4.9%
57	Hypernatremia	4.9%
58	Hypoglycemia	4.9%
59	Hypokalemia	4.9%
60	Hyponatremia	4.9%
61	Xanthomatosis	4.9%
62	Hypophosphatemia	4.9%
63	Metabolic acidosis	4.9%
64	Dyslipidemias	4.9%
65	Iron Overload	4.9%
66	Xanthoma	4.9%
67	Obesity, Abdominal	4.8%
68	Pseudohypoparathyroidism	4.4%
69	Brain Diseases, Metabolic, Inborn	3.9%
70	Pediatric Obesity	3.8%
71	Diabetes Mellitus	3.5%
72	Leigh Disease	3.4%
73	Dehydration	3.4%
74	Lipomatosis	3.4%
75	Water Intoxication	3.4%
76	Werner Syndrome	3.4%
77	Achlorhydria	3.3%
78	Amino Acid Metabolism, Inborn Errors	3.3%
79	Bloom Syndrome	3.3%
80	Carbohydrate Metabolism, Inborn Errors	3.3%
81	Metal Metabolism, Inborn Errors	3.3%
82	Osteoporosis	3.3%
83	Progeria	3.3%
84	Lysosomal Storage Diseases	3.3%
85	Bone Demineralization, Pathologic	3.3%
86	Cytochrome-c Oxidase Deficiency	3.3%
87	Peroxisomal Disorders	3.3%
88	Post-Traumatic Osteoporosis	3.3%
89	Prader-Willi Syndrome	3.3%
90	Celiac Disease	3.3%
91	Sprue, Tropical	3.3%
92	Steatorrhea	3.3%
93	Sprue	3.3%
94	Lactose Intolerance	3.2%
95	Acidosis, Lactic	3.2%
96	Calciphylaxis	3.2%
97	Hemosiderosis	3.2%
98	Hypolipoproteinemias	3.2%
99	Ketosis	3.2%
100	Ketonuria	3.2%
101	Ketoacidosis	3.2%
102	Ketonemia	3.2%
103	Vascular calcification	3.2%
104	Carbamoyl-Phosphate Synthase I Deficiency Disease	3%
105	Hyperlipoproteinemia Type IV	2.9%
106	Hyperlipoproteinemia Type V	2.9%
107	Diabetic Ketoacidosis	2.8%
108	Hyperlipidemia, Familial Combined	2.8%
109	Smith-Lemli-Opitz Syndrome	2.8%
110	Galactosemias	2.8%
111	Urea Cycle Disorders, Inborn	2.8%
112	Tyrosinemias	2.8%
113	Mitochondrial Encephalomyopathies	2.7%
114	Congenital Hyperinsulinism	2.7%
115	Hyperlipoproteinemia Type III	2.6%
116	Mitochondrial Myopathies	2.5%
117	Myelinolysis, Central Pontine	2.5%
118	Glycosuria	2.5%
119	Reye Syndrome	2.5%
120	Hepatic Encephalopathy	2.4%
121	Hyperphosphaturia	2.4%
122	Hypercholesterolemia	2.4%
123	Hyperlipoproteinemias	2.4%
124	Hypertriglyceridemia	2.4%
125	Hypoalphalipoproteinemias	2.4%
126	Homocystinuria	2.2%
127	Acidosis, Respiratory	2.2%
128	Adiposis Dolorosa	2.2%
129	Alkalosis, Respiratory	2.2%
130	Alkaptonuria	2.2%
131	Glycogen Storage Disease	2.2%
132	Hypophosphatasia	2.2%
133	Insulin Resistance	2.2%
134	Osteoporosis, Postmenopausal	2.2%
135	Propionic acidemia	2.2%
136	Dihydropyrimidine Dehydrogenase Deficiency	2.2%
137	Cystinosis	2.2%
138	Renal tubular acidosis	2.1%
139	Glycogen storage disease type II	2.1%
140	Gaucher Disease	2.1%
141	Amyloid Neuropathies, Familial	2%
142	Porphyrias, Hepatic	2%
143	Necrobiosis Lipoidica Diabeticorum	2%
144	Fanconi Anemia	1.9%
145	Nesidioblastosis	1.9%
146	Neuronal Ceroid-Lipofuscinoses	1.9%
147	HIV-Associated Lipodystrophy Syndrome	1.8%
148	Zellweger Syndrome	1.8%
149	MELAS Syndrome	1.8%
150	Menkes Kinky Hair Syndrome	1.8%
151	Adrenoleukodystrophy	1.7%
152	Gestational Diabetes	1.7%
153	Latent Autoimmune Diabetes in Adults	1.7%
154	Tay-Sachs Disease	1.7%
155	Diabetes Mellitus, Experimental	1.7%
156	Niemann-Pick Disease, Type C	1.6%
157	Hepatolenticular Degeneration	1.6%
158	Nephrocalcinosis	1.6%
159	Tetany	1.6%
160	Friedreich Ataxia	1.6%
161	Refsum Disease	1.6%
162	Glycosuria, Renal	1.6%
163	Cerebral Amyloid Angiopathy	1.6%
164	Glycogen Storage Disease Type I	1.6%
165	Glycogen Storage Disease Type V	1.6%
166	Mucopolysaccharidosis III	1.6%
167	Fabry Disease	1.6%
168	Kernicterus	1.4%
169	Cockayne Syndrome	1.4%
170	Familial Periodic Paralysis	1.3%
171	Primary amyloidosis	1.3%
172	Kearns-Sayre syndrome	1.3%
173	Variegate Porphyria	1.3%
174	Acute intermittent porphyria	1.3%
175	Porphyria Cutanea Tarda	1.3%
176	Renal Aminoacidurias	1.3%
177	Fanconi Syndrome	1.3%
178	Pseudohypoaldosteronism	1.3%
179	Liddle Syndrome	1.3%
180	Ataxia Telangiectasia	1.3%
181	Optic Atrophy, Hereditary, Leber	1.2%
182	Sjogren-Larsson Syndrome	1.1%
183	Xeroderma Pigmentosum	1.1%
184	Gout	1.1%
185	Amyotrophic Lateral Sclerosis	1.1%
186	Antley-Bixler Syndrome Phenotype	1.1%
187	Canavan Disease	1.1%
188	Alexander Disease	1.1%
189	Mucopolysaccharidosis II	1.1%
190	Hypokalemic periodic paralysis	1%
191	Frontotemporal dementia	1%
192	Cystinuria	1%
193	CREST Syndrome	0.9%
194	Albinism	0.8%
195	Arthritis, Gouty	0.8%
196	Ichthyosis, X-Linked	0.7%

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