MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteoporosis, Postmenopausal

(UMLS:C0029458)

Definition:: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
UMLS ID:: C0029458
MeSH ID:: D015663

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.198.579.610

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.104.579.610

Synonym(s)

Osteoporosis, Postmenopausal

Menopausal osteoporosis

Osteoporosis postmenopausal

POSTMENOPAUSAL OSTEOPOROSIS

Postmenopausal osteoporosis

Type 1 osteoporosis

Type I osteoporosis

bone loss postmenopausal

menopausal osteoporosis post

10.

osteoporosis post menopausal

11.

osteoporosis postmenopausal

12.

osteoporosis; postmenopausal

13.

post menopausal osteoporosis

14.

postmenopausal bone loss

15.

postmenopausal osteoporosis

16.

postmenopausal; osteoporosis

17.

type i osteoporosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	17 alpha-Hydroxyprogesterone Caproate	16373245	CTD
2	Alendronate	10447376 12730757 17439652	CTD
3	Calcitriol	10750555	CTD
4	Calcium Compounds	16167916	CTD
5	Dehydroepiandrosterone	16397352	CTD
6	Estradiol	11991445	CTD
7	Genistein	16169203	CTD
8	LY 117018	17638036 17907171	CTD
9	Norethindrone Acetate	11991445	CTD
10	Ospemifene	16816926	CTD
11	Quercetin	19495926	CTD
12	Raloxifene Hydrochloride	View details 11475503 15231013 15458908 15579764 15758505 16167916 16197663 16804122 17439652 17473493 17823083 17893378 25299349	CTD
13	Resveratrol	17513867	CTD
14	Risedronic Acid	17349419	CTD
15	Vitamin D	10447376 25299349	CTD
16	alfacalcidol	10750555	CTD
17	bazedoxifene	22429462	CTD
18	tibolone	11991445	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Bone Demineralization, Pathologic	34.4%
2	Rickets	28.4%
3	Pseudohypoparathyroidism	26.6%
4	Osteomalacia	18.8%
5	Osteoarthropathy, Secondary Hypertrophic	16.9%
6	Wasting Syndrome	16.9%
7	Acid-Base Imbalance	16.7%
8	Bone Diseases, Developmental	16.7%
9	Calcium Metabolism Disorders	16.7%
10	Iron Metabolism Disorders	16.7%
11	Hyperostosis	16.7%
12	Osteitis	16.7%
13	Osteitis Deformans	16.7%
14	Osteochondrosis	16.7%
15	Phosphorus Metabolism Disorders	16.7%
16	Spinal Diseases	16.7%
17	Water-Electrolyte Imbalance	16.7%
18	Lipid Metabolism Disorders	16.7%
19	Mitochondrial Diseases	16.7%
20	Glucose Metabolism Disorders	16.7%
21	Hypercalcemia	14.8%
22	Hypocalcemia	14.8%
23	Milk-Alkali Syndrome	14.8%
24	Osteochondritis	13.5%
25	Bone Diseases, Endocrine	13.2%
26	Bone Diseases, Infectious	12.7%
27	Bone neoplasms	12.7%
28	Renal Osteodystrophy	12.6%
29	Renal rickets	12.6%
30	Bone Resorption	12.5%
31	Brain Diseases, Metabolic	12.5%
32	Aseptic Necrosis of Bone	12.5%
33	Gigantism	11.8%
34	Lipodystrophy	11.8%
35	Spinal Neoplasms	11.8%
36	Spondylitis	11.8%
37	Platybasia	11.5%
38	Fasciitis	10.5%
39	Foot Deformities	10.5%
40	Arthropathy	10.5%
41	Nutrition Disorders	10.5%
42	Familial Hypophosphatemic Rickets	10.1%
43	Brain Diseases, Metabolic, Inborn	9.8%
44	Acidosis	9.8%
45	Ainhum	9.8%
46	Alkalosis	9.8%
47	Amyloidosis	9.8%
48	Calcinosis	9.8%
49	Dysostoses	9.8%
50	Hyperglycemia	9.8%
51	Hyperinsulinism	9.8%
52	Hyperkalemia	9.8%
53	Hypernatremia	9.8%
54	Hypoglycemia	9.8%
55	Hypokalemia	9.8%
56	Hyponatremia	9.8%
57	Spinal Stenosis	9.8%
58	Spondylosis	9.8%
59	Xanthomatosis	9.8%
60	Hypophosphatemia	9.8%
61	Intervertebral Disc Degeneration	9.8%
62	Metabolic acidosis	9.8%
63	Dyslipidemias	9.8%
64	Iron Overload	9.8%
65	Xanthoma	9.8%
66	Mitochondrial Myopathies	9.3%
67	Pectus excavatum	9.3%
68	Pectus carinatum	9.1%
69	Leigh Disease	9.1%
70	Hyperhomocysteinemia	8.7%
71	Arthrogryposis	8.5%
72	Contracture	8.5%
73	Fasciitis, Plantar	8.5%
74	Mitochondrial Encephalomyopathies	8.4%
75	Jaw Diseases	8.2%
76	Lactose Intolerance	8.1%
77	Gout	8%
78	Carbamoyl-Phosphate Synthase I Deficiency Disease	8%
79	Cartilage Diseases	7.9%
80	Foot Diseases	7.9%
81	Myopathy	7.9%
82	Rheumatism	7.9%
83	Chondromalacia	7.9%
84	Diabetes Mellitus	7.8%
85	Discitis	7.7%
86	Hypolipoproteinemias	7.7%
87	Dehydration	7.5%
88	Lipomatosis	7.5%
89	Multiple Epiphyseal Dysplasia	7.5%
90	Osteochondrodysplasias	7.5%
91	Water Intoxication	7.5%
92	Werner Syndrome	7.5%
93	Achlorhydria	7.4%
94	Amino Acid Metabolism, Inborn Errors	7.4%
95	Bloom Syndrome	7.4%
96	Carbohydrate Metabolism, Inborn Errors	7.4%
97	Metal Metabolism, Inborn Errors	7.4%
98	Osteomyelitis	7.4%
99	Periostitis	7.4%
100	Progeria	7.4%
101	Lysosomal Storage Diseases	7.4%
102	Cytochrome-c Oxidase Deficiency	7.4%
103	Peroxisomal Disorders	7.4%
104	Alveolar Bone Loss	7.3%
105	Celiac Disease	7.3%
106	Femur Head Necrosis	7.3%
107	Sprue, Tropical	7.3%
108	Steatorrhea	7.3%
109	Sprue	7.3%
110	Osteolysis	7.3%
111	Smith-Lemli-Opitz Syndrome	7.3%
112	Klippel-Feil Syndrome	7.3%
113	Synostosis	7.3%
114	Galactosemias	7.2%
115	Urea Cycle Disorders, Inborn	7.2%
116	Tyrosinemias	7.2%
117	Hyperlipoproteinemia Type IV	7.2%
118	Hyperlipoproteinemia Type V	7.2%
119	Congenital Hypothyroidism	7.1%
120	Eosinophilic Granuloma	7%
121	Diabetic Ketoacidosis	6.8%
122	Fibromyalgia	6.8%
123	Polymyalgia Rheumatica	6.8%
124	Hyperlipidemia, Familial Combined	6.8%
125	Metatarsalgia	6.7%
126	Congenital Hyperinsulinism	6.7%
127	Acidosis, Lactic	6.5%
128	Calciphylaxis	6.5%
129	Chondrodysplasia Punctata	6.5%
130	Enchondromatosis	6.5%
131	Hemosiderosis	6.5%
132	Ketosis	6.5%
133	Lordosis	6.5%
134	Osteosclerosis	6.5%
135	Spondylolysis	6.5%
136	Ketonuria	6.5%
137	Ketoacidosis	6.5%
138	Ketonemia	6.5%
139	Vascular calcification	6.5%
140	kyphosis	6.5%
141	Kashin-Beck Disease	6.5%
142	Hyperphosphaturia	6.4%
143	Tuberculosis, Spinal	6.4%
144	Hyperlipoproteinemia Type III	6.3%
145	Dwarfism	6.2%
146	Antley-Bixler Syndrome Phenotype	6.2%
147	Osteoarthritis, Spine	6.2%
148	Cockayne Syndrome	6.2%
149	Familial Periodic Paralysis	6%
150	Myelinolysis, Central Pontine	6%
151	Homocystinuria	5.9%
152	Glycosuria	5.9%
153	Reye Syndrome	5.9%
154	Acromegaly	5.9%
155	Joint Tuberculosis	5.9%
156	Tuberculosis, Osteoarticular	5.9%
157	Bone Tuberculosis	5.9%
158	Craniofacial Dysostosis	5.8%
159	Hepatic Encephalopathy	5.8%
160	Hypoalphalipoproteinemias	5.8%
161	Glycogen storage disease type II	5.7%
162	Gaucher Disease	5.6%
163	HIV Wasting Syndrome	5.6%
164	Arthritis	5.6%
165	Bursitis	5.6%
166	Child Nutrition Disorders	5.6%
167	Hypervitaminosis A	5.6%
168	Infant Nutrition Disorders	5.6%
169	Joint Instability	5.6%
170	Myofascial Pain Syndromes	5.6%
171	Rhabdomyolysis	5.6%
172	Synovitis	5.6%
173	Joint laxity	5.6%
174	Polyarthritis	5.6%
175	Malnutrition	5.6%
176	Frozen shoulder	5.6%
177	Patellofemoral Pain Syndrome	5.6%
178	Renal tubular acidosis	5.5%
179	Amyloid Neuropathies, Familial	5.4%
180	MELAS Syndrome	5.4%
181	Ankylosing spondylitis	5.3%
182	Arthritis, Gouty	5.3%
183	Rheumatic Fever	5.3%
184	Spondylarthropathies	5.2%
185	Porphyrias, Hepatic	5%
186	Ischemic contracture	4.9%
187	Hip Contracture	4.9%
188	Periarthritis	4.9%
189	Necrobiosis Lipoidica Diabeticorum	4.9%
190	Zellweger Syndrome	4.9%
191	Acidosis, Respiratory	4.9%
192	Adiposis Dolorosa	4.9%
193	Alkalosis, Respiratory	4.9%
194	Craniosynostosis	4.9%
195	Syndactyly	4.9%
196	Brachycephaly	4.9%
197	Fanconi Anemia	4.9%
198	Nesidioblastosis	4.9%
199	Neuronal Ceroid-Lipofuscinoses	4.9%
200	Temporomandibular Joint Disorders	4.9%
201	HIV-Associated Lipodystrophy Syndrome	4.8%
202	Alkaptonuria	4.8%
203	Glycogen Storage Disease	4.8%
204	Hypophosphatasia	4.8%
205	Insulin Resistance	4.8%
206	Menkes Kinky Hair Syndrome	4.8%
207	Propionic acidemia	4.8%
208	Dihydropyrimidine Dehydrogenase Deficiency	4.8%
209	Cystinosis	4.8%
210	Adrenoleukodystrophy	4.8%
211	Hypercholesterolemia	4.8%
212	Hyperlipoproteinemias	4.8%
213	Hypertriglyceridemia	4.8%
214	Melorheostosis	4.8%
215	Osteopetrosis	4.8%
216	Spondylolisthesis	4.8%
217	Wernicke Encephalopathy	4.7%
218	Tay-Sachs Disease	4.6%
219	Niemann-Pick Disease, Type C	4.5%
220	Hepatolenticular Degeneration	4.5%
221	Rheumatoid Arthritis	4.5%
222	Juvenile arthritis	4.5%
223	Refsum Disease	4.5%
224	Fabry Disease	4.4%
225	Arthritis, Psoriatic	4.4%
226	Glycosuria, Renal	4.3%
227	Compartment syndromes	4.2%
228	Maxillary Diseases	4.2%
229	Tendinitis	4.2%
230	Tendinopathy	4.2%
231	Hemarthrosis	4.2%
232	Myositis	4.2%
233	Tietze's Syndrome	4.2%
234	Limb Deformities, Congenital	4.2%
235	Isaacs syndrome	4.2%
236	Craniofacial Abnormalities	4.2%
237	Myotonic Disorders	4.2%
238	Friedreich Ataxia	4.2%
239	Kearns-Sayre syndrome	4.2%
240	Acrocephalosyndactylia	4.1%
241	Mucopolysaccharidosis III	4.1%
242	Osteoarthritis, Knee	4.1%
243	Talipes	4%
244	Hypokalemic periodic paralysis	4%
245	Gestational Diabetes	4%
246	Latent Autoimmune Diabetes in Adults	4%
247	Diabetes Mellitus, Experimental	4%
248	Osteogenesis Imperfecta	4%
249	Nephrocalcinosis	3.9%
250	Tetany	3.9%
251	Temporomandibular Joint Dysfunction Syndrome	3.9%
252	Arthritis, Reactive	3.9%
253	Mastoiditis	3.9%
254	Petrositis	3.9%
255	Cerebral Amyloid Angiopathy	3.8%
256	Kernicterus	3.7%
257	Glycogen Storage Disease Type I	3.6%
258	Glycogen Storage Disease Type V	3.6%
259	Poland Syndrome	3.5%
260	Mandibulofacial Dysostosis	3.5%
261	Medial Tibial Stress Syndrome	3.4%
262	Marfan Syndrome	3.3%
263	Goldenhar Syndrome	3.3%
264	Ataxia Telangiectasia	3.3%
265	Muscle Cramp	3.3%
266	Eosinophilia-Myalgia Syndrome	3.3%
267	Gastroschisis	3.3%
268	Muscle Rigidity	3.3%
269	Muscle Spasticity	3.3%
270	Cogwheel Rigidity	3.3%
271	Primary amyloidosis	3.3%
272	Nuchal Rigidity	3.3%
273	Rubinstein-Taybi Syndrome	3.3%
274	Basal Cell Nevus Syndrome	3.3%
275	Bunion	3.3%
276	Deficiency Diseases	3.3%
277	Fibrodysplasia Ossificans Progressiva	3.3%
278	Myoglobinuria	3.3%
279	Myositis Ossificans	3.3%
280	Starvation	3.3%
281	Tenosynovitis	3.3%
282	Sacroiliitis	3.3%
283	Refeeding Syndrome	3.3%
284	Rheumatoid Nodule	3.2%
285	Variegate Porphyria	3.2%
286	Acute intermittent porphyria	3.2%
287	Porphyria Cutanea Tarda	3.2%
288	Optic Atrophy, Hereditary, Leber	3.2%
289	Renal Aminoacidurias	3.2%
290	Fanconi Syndrome	3.2%
291	Pseudohypoaldosteronism	3.2%
292	Liddle Syndrome	3.2%
293	Sjogren-Larsson Syndrome	3.1%
294	Palatal Neoplasms	3%
295	Xeroderma Pigmentosum	3%
296	Chronic Fatigue Syndrome	2.9%
297	Canavan Disease	2.9%
298	Alexander Disease	2.9%
299	Jaw Abnormalities	2.9%
300	Mucopolysaccharidosis II	2.9%
301	Amyotrophic Lateral Sclerosis	2.8%
302	Nail-Patella Syndrome	2.8%
303	Congenital clubfoot	2.8%
304	Vertical Talus	2.8%
305	Giant Cell Epulis	2.8%
306	Muscle Weakness	2.8%
307	Musculoskeletal Pain	2.8%
308	Arthralgia	2.7%
309	Polyarthralgia	2.7%
310	Felty Syndrome	2.7%
311	Arthritis, Infectious	2.5%
312	Anterior Compartment Syndrome	2.5%
313	Enthesopathy	2.5%
314	Arthritis, Experimental	2.5%
315	Abdominal Compartment Syndrome	2.5%
316	Amelia	2.4%
317	Arachnodactyly	2.4%
318	Ectromelia	2.4%
319	Hemimelia	2.4%
320	Phocomelia	2.4%
321	Sirenomelia	2.4%
322	Polymyositis	2.4%
323	Polydactyly	2.4%
324	Brachydactyly	2.4%
325	Plagiocephaly	2.4%
326	Lower Extremity Deformities, Congenital	2.4%
327	Upper Extremity Deformities, Congenital	2.4%
328	Prognathism	2.4%
329	Laryngomalacia	2.4%
330	CREST Syndrome	2.4%
331	Frontotemporal dementia	2.4%
332	Cystinuria	2.4%
333	Myalgia	2.3%
334	Rheumatoid Vasculitis	2.3%
335	Nose Neoplasms	2.2%
336	Albinism	2.2%
337	Kwashiorkor	2.2%
338	Magnesium Deficiency	2.2%
339	Potassium Deficiency	2.2%
340	Protein Deficiency	2.2%
341	Avitaminosis	2.2%
342	Sicca Syndrome	2%
343	Sjogren's Syndrome	2%
344	Hip Dislocation	2%
345	Shoulder Dislocation	2%
346	Hip Dysplasia	2%
347	Muscular Dystrophy	2%
348	Orbital Myositis	2%
349	Dupuytren Contracture	2%
350	Pyomyositis	2%
351	Micrognathism	1.8%
352	Pierre Robin Syndrome	1.8%
353	Myotonic Dystrophy	1.8%
354	Ichthyosis, X-Linked	1.8%
355	Maxillofacial Abnormalities	1.7%
356	Myotonia Congenita	1.6%
357	Bronchomalacia	1.6%
358	Tracheomalacia	1.6%
359	Retrognathia	1.6%
360	Microcephaly	1.6%
361	Macrocephaly	1.6%
362	Shoulder Pain	1.6%
363	Obesity	1.6%
364	Ascorbic Acid Deficiency	1.6%
365	Vitamin A Deficiency	1.6%
366	Vitamin D Deficiency	1.6%
367	Vitamin E Deficiency	1.6%
368	Marasmus	1.6%
369	Folic Acid Deficiency	1.3%
370	Pellagra	1.3%
371	Thiamine Deficiency	1.3%
372	Vitamin B 12 Deficiency	1.3%
373	Vitamin B 6 Deficiency	1.3%
374	Pyridoxine Deficiency	1.3%
375	Cleft Palate	1.3%
376	Welander Distal Myopathy	1.3%
377	Obesity, Abdominal	1.3%
378	Noonan Syndrome	1.2%
379	Beriberi	1.2%
380	Dermatomyositis	1.1%
381	Holoprosencephaly	1.1%
382	Muscular Dystrophy, Duchenne	1.1%
383	Porencephaly	1.1%
384	Pediatric Obesity	1.1%
385	Vitamin K Deficiency	1%
386	Prader-Willi Syndrome	0.9%
387	Anemia, Pernicious	0.9%
388	Scurvy	0.8%
389	Radicular Cyst	0.7%
390	Subacute Combined Degeneration	0.5%

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