MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Myocardial Reperfusion Injury

(UMLS:C0027055)

Definition:: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
UMLS ID:: C0027055
MeSH ID:: D015428

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.238.615|C14.280.647.625|C14.907.585.625|C14.907.725.600

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.767.877.500

Synonym(s)

Myocardial Reperfusion Injury

Myocardial reperfusion injury

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bosentan	FAERS: 1	16700825	CTD US FAERS
2	11-keto-boswellic acid		23771412	CTD
3	Acetylcysteine		9188292 21912612	CTD
4	Allopurinol		21912612	CTD
5	Amlodipine		1839439 9488200	CTD
6	Aprindine		8935716	CTD
7	Atorvastatin		15837263	CTD
8	Auranofin		15191400	CTD
9	Calcium Compounds		19593760	CTD
10	Carnitine		29186614	CTD
11	Carvedilol		8957224 15148268	CTD
12	Chromium		19027847	CTD
13	Clenbuterol		20590644	CTD
14	Cocaine		15685203	CTD
15	Deferoxamine		1540057	CTD
16	Diltiazem		11721720	CTD
17	Estradiol		16810080	CTD
18	Fluvastatin		28951255	CTD
19	Genistein		17141266	CTD
20	Glucose		25488258 29702141	CTD
21	Ipratropium		24431217	CTD
22	Isoflurane		17693941	CTD
23	Lithium		18789320	CTD
24	Losartan		11893553	CTD
25	Malondialdehyde		16700825	CTD
26	Metoprolol		20590644	CTD
27	Milrinone		20680905	CTD
28	Minocycline		14998631	CTD
29	Morphine		15345483	CTD
30	N(6)-cyclohexyladenosine		11893553	CTD
31	Nandrolone		15778771	CTD
32	Niacin		10924076 19027847	CTD
33	Nicotine		8124816	CTD
34	Nitric Oxide		14990356	CTD
35	Nitroglycerin		9188292	CTD
36	Norepinephrine		15642760	CTD
37	Oxygen		View details 25305180 25488258 26464617 26593335 29702141	CTD
38	PD 123319		11893553	CTD
39	Pioglitazone		28744220	CTD
40	Propofol		21468576	CTD
41	Propranolol		10512524	CTD
42	Quercetin		19207477	CTD
43	Ramipril		2535056	CTD
44	Resveratrol		View details 12003803 14990356 15345477 21203465 22050707 25488258 26464617	CTD
45	Rosiglitazone		View details 11714655 16582019 18562925 19566839	CTD
46	Rosuvastatin Calcium		12354446	CTD
47	SEA 0400		15215644 19593760	CTD
48	Sildenafil Citrate		12181158	CTD
49	Simvastatin		11742885	CTD
50	Streptozocin		21912612	CTD
51	Tiopronin		8124816	CTD
52	Trinitrotoluene		26464617	CTD
53	Valsartan		28951255	CTD
54	Verapamil		10832809	CTD
55	WAY-169916		16810080	CTD
56	Yohimbine		2350327	CTD
57	benazepril		20026869	CTD
58	falipamil		3735124	CTD
59	geraniol		28131760	CTD
60	ginsenoside Rg1		26593335	CTD
61	magnesium tanshinoate B		18066107	CTD
62	nicainoprol		2535056	CTD
63	nitroaspirin		17526656	CTD
64	notoginsenoside R1		25305180	CTD
65	olmesartan		18434761	CTD
66	pirinixic acid		16411023	CTD
67	plastochromanol 8		22050707	CTD
68	ramiprilat		2535056 7856280	CTD
69	reviparin		10843908	CTD
70	rofecoxib		18679128	CTD
71	rosmarinic acid		28744220	CTD
72	terutroban		18679128	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Coronary heart disease	45.5%
2	Myocardial Infarction	45.5%
3	Acute Coronary Syndrome	45.5%
4	Coronary Aneurysm	42.8%
5	Angina Pectoris	40.2%
6	Kounis Syndrome	40.2%
7	Coronary Thrombosis	39.3%
8	Coronary Artery Disease	39.3%
9	Cardiomyopathy, Dilated	37.9%
10	Primary Graft Dysfunction	36.8%
11	Arrhythmogenic Right Ventricular Dysplasia	35.3%
12	Coronary Occlusion	33.8%
13	Microvascular Angina	33.8%
14	Coronary Stenosis	33.8%
15	ST segment elevation myocardial infarction	33.8%
16	Shock, Cardiogenic	33.3%
17	Postpericardiotomy Syndrome	33%
18	Vasoplegia	33%
19	Hypertrophic Cardiomyopathy	32%
20	Hypertrophic obstructive cardiomyopathy	32%
21	Aortic Aneurysm	30.3%
22	Aortic Valve Stenosis	30.3%
23	Aortitis	30.3%
24	Leriche Syndrome	30.3%
25	Periphlebitis	30.3%
26	Phlebitis	30.3%
27	Pulmonary Valve Stenosis	30.3%
28	Thromboangiitis Obliterans	30.3%
29	Heart Block	30.3%
30	Tachycardia	30.3%
31	Tachyarrhythmia	30.3%
32	Angina, Unstable	29.9%
33	Tricuspid Atresia	29.4%
34	Myocardial Ischemia	29%
35	Retinal Vein Occlusion	28.5%
36	Coronary Restenosis	28%
37	Thrombophlebitis	27.8%
38	Sick Sinus Syndrome	27.5%
39	Long QT Syndrome	26.8%
40	Arteriovenous fistula	26.8%
41	Aneurysm	26.8%
42	Angiomatosis	26.8%
43	Aortic Diseases	26.8%
44	Arterial Occlusive Diseases	26.8%
45	Cardiac Tamponade	26.8%
46	Endocarditis	26.8%
47	Cardiac Arrest	26.8%
48	Heart failure	26.8%
49	Hyperemia	26.8%
50	Hypotension	26.8%
51	Pericardial effusion	26.8%
52	Pericarditis	26.8%
53	Pneumopericardium	26.8%
54	Cor pulmonale	26.8%
55	Superior Vena Cava Syndrome	26.8%
56	Telangiectasis	26.8%
57	Vasculitis	26.8%
58	Venous Insufficiency	26.8%
59	Ventricular Outflow Obstruction	26.8%
60	Peripheral Vascular Diseases	26.8%
61	Embolism and Thrombosis	26.8%
62	Angiodysplasia	26.8%
63	Ventricular Dysfunction	26.8%
64	Capillary Leak Syndrome	26.8%
65	Pleuropericarditis	26.8%
66	Prehypertension	26.8%
67	Malignant Atrophic Papulosis	26.6%
68	Restrictive cardiomyopathy	26.5%
69	Endocardial Fibroelastosis	26.5%
70	Myocarditis	26.5%
71	Endomyocardial Fibrosis	26.5%
72	Carditis	26.5%
73	Myocardial Reperfusion Injury	26.5%
74	Aortic Rupture	26.5%
75	Shwartzman Phenomenon	26.4%
76	Postphlebitic Syndrome	26.4%
77	Cardiac Output, High	25.6%
78	Myocardial Stunning	25.6%
79	Low Cardiac Output Syndrome	25.6%
80	Angina Pectoris, Variant	24.9%
81	Moyamoya Disease	24.8%
82	Carotid Artery Thrombosis	24.6%
83	Cardiomegaly	24.4%
84	Cardiac Hypertrophy	24.4%
85	Vascular System Injuries	23.6%
86	Blue Toe Syndrome	23.5%
87	Compartment syndromes	23.2%
88	Hepatic Veno-Occlusive Disease	23.2%
89	Peliosis Hepatis	23.2%
90	Varicocele	23.2%
91	Intracranial Embolism and Thrombosis	23%
92	Carotid Stenosis	23%
93	Intracranial Aneurysm	23%
94	Cerebrovascular Disorders	23%
95	Diabetic Angiopathies	23%
96	Splenic Infarction	23%
97	Cerebrovascular Insufficiency	23%
98	Vascular Neoplasms	23%
99	Spinal Cord Vascular Diseases	23%
100	Hemorrhoids	22.9%
101	Thoracic Outlet Syndrome	22.9%
102	Rheumatic Heart Disease	22.8%
103	Diabetic Cardiomyopathies	22.7%
104	Cardiomyopathy, Alcoholic	22.6%
105	Chagas Cardiomyopathy	22.6%
106	Supravalvular aortic stenosis	22.5%
107	Lown-Ganong-Levine Syndrome	22.5%
108	Aortic Aneurysm, Abdominal	22.5%
109	Aortic Aneurysm, Thoracic	22.5%
110	Adams-Stokes Syndrome	22.1%
111	Atrioventricular Block	22.1%
112	Bundle-Branch Block	22.1%
113	Atrial Premature Complexes	22.1%
114	Sinoatrial Block	22.1%
115	Tachycardia, Paroxysmal	22.1%
116	Supraventricular tachycardia	22.1%
117	Tachycardia, Ventricular	22.1%
118	Tachycardia, Reciprocating	22.1%
119	Vasculitis, Central Nervous System	21.3%
120	No-Reflow Phenomenon	21.2%
121	Bacterial Endocarditis	21%
122	Hand-Arm Vibration Syndrome	20.6%
123	Optic Neuropathy, Ischemic	20.3%
124	Anterior Ischemic Optic Neuropathy	20.3%
125	Mesenteric vascular insufficiency	20.3%
126	Embolism, Amniotic Fluid	20%
127	Angioedema	19.9%
128	Colitis, Ischemic	19.9%
129	Aortic coarctation	19.8%
130	Cor Triatriatum	19.8%
131	Coronary Vessel Anomalies	19.8%
132	Patent ductus arteriosus	19.8%
133	Ebstein Anomaly	19.8%
134	Heart Septal Defects	19.8%
135	Tetralogy of Fallot	19.8%
136	Transposition of Great Vessels	19.8%
137	Hypoplastic Left Heart Syndrome	19.8%
138	May-Thurner Syndrome	19.8%
139	Polyarteritis Nodosa	19.8%
140	Takayasu Arteritis	19.8%
141	Pregnancy Complications, Cardiovascular	19.7%
142	Cardiovascular Abnormalities	19.7%
143	Wolff-Parkinson-White Syndrome	19.7%
144	Giant Cell Arteritis	19.6%
145	Temporal Arteritis	19.6%
146	Intracranial Arteriosclerosis	19.6%
147	Cerebral Atherosclerosis	19.6%
148	Scimitar Syndrome	19.6%
149	Cerebral Arteriosclerosis	19.6%
150	Romano-Ward Syndrome	19.6%
151	Sinus Arrhythmia	19.4%
152	Atrial Fibrillation	19.4%
153	Atrial Flutter	19.4%
154	Ventricular Fibrillation	19.4%
155	Ventricular Flutter	19.4%
156	Parasystole	19.4%
157	Paroxysmal atrial fibrillation	19.4%
158	Bradycardia	19.4%
159	Tachycardia, Atrioventricular Nodal Reentry	18.1%
160	Tachycardia, Ectopic Atrial	18.1%
161	Tachycardia, Ectopic Junctional	18.1%
162	Sinus Tachycardia	18.1%
163	Torsades de Pointes	18.1%
164	Accelerated Idioventricular Rhythm	18.1%
165	Cerebral Thrombosis	18%
166	Intracranial Embolism	18%
167	Intracranial Thrombosis	18%
168	Sudden Cardiac Death	17.9%
169	Aneurysm, Dissecting	17.7%
170	Aortic Valve Insufficiency	17.7%
171	Arteriosclerosis	17.7%
172	Arteritis	17.7%
173	Embolism	17.7%
174	Erythromelalgia	17.7%
175	Fibromuscular Dysplasia	17.7%
176	Heart Rupture, Post-Infarction	17.7%
177	Malignant Hypertension	17.7%
178	Mitral Valve Insufficiency	17.7%
179	Mitral Valve Stenosis	17.7%
180	Pericarditis, Constrictive	17.7%
181	Pulmonary Valve Insufficiency	17.7%
182	Raynaud Disease	17.7%
183	Thromboembolism	17.7%
184	Thrombosis	17.7%
185	Tricuspid Valve Insufficiency	17.7%
186	Tricuspid Valve Stenosis	17.7%
187	Essential Hypertension	17.7%
188	Aneurysm, Ruptured	17.7%
189	Iliac Aneurysm	17.7%
190	Pulmonary artery stenosis	17.7%
191	Ventricular Dysfunction, Left	17.7%
192	Right Ventricular Dysfunction	17.7%
193	White Coat Hypertension	17.7%
194	Systemic Vasculitis	17.7%
195	Heart Failure, Systolic	17.7%
196	Heart Failure, Diastolic	17.7%
197	Embolus	17.7%
198	Dextrocardia	17.6%
199	Carcinoid Heart Disease	17.5%
200	Lemierre Syndrome	17.4%
201	Brain Infarction	17.4%
202	Subarachnoid Hemorrhage, Traumatic	17.3%
203	Carotid Artery, Internal, Dissection	17.3%
204	Cardiomyopathies	16.8%
205	CREST Syndrome	16.6%
206	Edema, Cardiac	16.6%
207	Infarction, Middle Cerebral Artery	16.4%
208	Infarction, Anterior Cerebral Artery	16.4%
209	Infarction, Posterior Cerebral Artery	16.4%
210	Left Ventricular Hypertrophy	16%
211	Right Ventricular Hypertrophy	16%
212	Vertebral Artery Dissection	15.8%
213	Sinus Thrombosis, Intracranial	15.4%
214	Retinal Artery Occlusion	15.3%
215	Retinal Vasculitis	15.3%
216	Hypertensive Retinopathy	15.3%
217	Anterior Compartment Syndrome	15.2%
218	Vasculitis, Leukocytoclastic, Cutaneous	15.2%
219	Gastric Antral Vascular Ectasia	15.2%
220	Abdominal Compartment Syndrome	15.2%
221	Carotid Artery Diseases	15.1%
222	Brain Ischemia	15.1%
223	Hypotension, Orthostatic	15.1%
224	Cerebrovascular accident	15.1%
225	Varicose Ulcer	15.1%
226	Vasospasm, Intracranial	15.1%
227	Spinal Cord Ischemia	15.1%
228	Intracranial Arterial Diseases	15.1%
229	Post-Exercise Hypotension	15.1%
230	Aortopulmonary Septal Defect	14.7%
231	Double Outlet Right Ventricle	14.7%
232	Endocardial Cushion Defects	14.7%
233	Myocardial bridging	14.7%
234	Aorticopulmonary Septal Defect	14.7%
235	Livedo Reticularis	14.5%
236	Noonan Syndrome	14.5%
237	Cerebral Infarction	14.4%
238	Brain Stem Infarctions	14.4%
239	Reperfusion Injury	14.4%
240	Carotid Artery Injuries	14.3%
241	Basal Ganglia Hemorrhage	14.3%
242	Postoperative Hemorrhage	14.2%
243	Cavernous Sinus Thrombosis	14.2%
244	Sagittal Sinus Thrombosis	14.2%
245	Sinus Arrest, Cardiac	14.1%
246	Dyspnea, Paroxysmal	14%
247	Intermittent Claudication	13.8%
248	Marfan Syndrome	13.4%
249	Mesenteric Vascular Occlusion	13.4%
250	Mucocutaneous Lymph Node Syndrome	13.4%
251	Diabetic Retinopathy	13.3%
252	Sturge-Weber Syndrome	13.3%
253	Renal hypertension	13.2%
254	Renal Artery Obstruction	13.2%
255	Renal Artery Stenosis	13.2%
256	Aortic Valve Prolapse	13.2%
257	Arteriosclerosis Obliterans	13.2%
258	Atherosclerosis	13.2%
259	Air Embolism	13.2%
260	Endarteritis	13.2%
261	Tricuspid Valve Prolapse	13.2%
262	Venous Thrombosis	13.2%
263	Deep Vein Thrombosis	13.2%
264	Takotsubo Cardiomyopathy	13.2%
265	Venous Thromboembolism	13.2%
266	Hemangioma, Cavernous	13.2%
267	Basal Ganglia Cerebrovascular Disease	13.2%
268	Subacute Bacterial Endocarditis	13.2%
269	Vascular Headaches	13.1%
270	Scurvy	13.1%
271	Purpura, Hyperglobulinemic	13.1%
272	Lateral Medullary Syndrome	12.9%
273	Subarachnoid Hemorrhage	12.3%
274	Cerebral Hemorrhage	12.3%
275	Putaminal Hemorrhage	12.2%
276	Truncus Arteriosus, Persistent	12.2%
277	Ischemic contracture	11.8%
278	Angioedemas, Hereditary	11.8%
279	Cryoglobulinemia	11.7%
280	Leukomalacia, Periventricular	11.7%
281	Diabetic Foot	11.7%
282	Graft Occlusion, Vascular	11.6%
283	Surgical Wound Dehiscence	11.6%
284	Delayed Emergence from Anesthesia	11.6%
285	Anastomotic Leak	11.6%
286	Heart Diseases	11.4%
287	Pulmonary Embolism	11.4%
288	Vascular Diseases	11.4%
289	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	11.4%
290	Incisional hernia	11.4%
291	Cerebral Arterial Diseases	11.2%
292	Vertebrobasilar Insufficiency	11.2%
293	Anterior Spinal Artery Syndrome	11.2%
294	Basilar Artery Stenosis	11.2%
295	Vertebral Artery Stenosis	11.2%
296	Intracranial Hemorrhage, Hypertensive	11.2%
297	Transient Cerebral Ischemia	11.2%
298	Pain, Postoperative	10.8%
299	Dementia, Vascular	10.8%
300	Kearns-Sayre syndrome	10.7%
301	Failed Back Surgery Syndrome	10.6%
302	Shy-Drager Syndrome	10.5%
303	Postoperative Nausea and Vomiting	10.3%
304	Prosthesis Failure	10%
305	Corneal Endothelial Cell Loss	10%
306	Surgical Wound Infection	10%
307	Afferent Loop Syndrome	9.9%
308	Short Bowel Syndrome	9.9%
309	Hypertension, Renovascular	9.8%
310	Hypoxia-Ischemia, Brain	9.8%
311	Lupus Vasculitis, Central Nervous System	9.8%
312	Hereditary Angioedema Type III	9.8%
313	Hereditary Angioedema Types I and II	9.8%
314	Polydipsia	9.7%
315	Behcet Syndrome	9.7%
316	Waldenstrom Macroglobulinemia	9.6%
317	Multiple Myeloma	9.6%
318	Hepatic Vein Thrombosis	9.5%
319	Budd-Chiari Syndrome	9.5%
320	Hematoma, Subdural	9.5%
321	Hematoma, Epidural, Cranial	9.5%
322	Pulmonary Infarction	9.4%
323	Subclavian Steal Syndrome	9.3%
324	Ataxia Telangiectasia	8.9%
325	Pseudoxanthoma Elasticum	8.9%
326	Pituitary Apoplexy	8.8%
327	Turner Syndrome	8.6%
328	Infarction	8.5%
329	Shock, Hemorrhagic	8.5%
330	Systemic Inflammatory Response Syndrome	8.5%
331	Vascular Remodeling	8.5%
332	Ascites	8.4%
333	Fibrosis	8.4%
334	Gliosis	8.4%
335	Growth Disorders	8.4%
336	Hemorrhage	8.4%
337	Hyperbilirubinemia	8.4%
338	Hyperplasia	8.4%
339	Hypomenorrhea	8.4%
340	Inflammation	8.4%
341	Intraoperative Complications	8.4%
342	Ischemia	8.4%
343	Lithiasis	8.4%
344	Malacoplakia	8.4%
345	Menstruation Disturbances	8.4%
346	Metaplasia	8.4%
347	Nerve Degeneration	8.4%
348	Ochronosis	8.4%
349	Polymenorrhea	8.4%
350	Sclerosis	8.4%
351	Shock	8.4%
352	Ulcer	8.4%
353	Hyperammonemia	8.4%
354	Hyperamylasemia	8.4%
355	Teratogenesis	8.4%
356	Cardiac Death	8.4%
357	Hypovolemia	8.4%
358	Hyperuricemia	8.4%
359	Leukoaraiosis	8.4%
360	Dysbacteriosis	8.4%
361	Delayed Graft Function	8.4%
362	Cirrhosis	8.4%
363	Neointima	8.4%
364	Dysbiosis	8.4%
365	Granulomatosis with polyangiitis	8.2%
366	Cerebral Amyloid Angiopathy	8.2%
367	Hematoma, Subdural, Intracranial	7.9%
368	Hematoma, Subdural, Chronic	7.9%
369	Hematoma, Subdural, Acute	7.9%
370	Rheumatoid Vasculitis	7.9%
371	Ectopia Cordis	7.5%
372	Single umbilical artery	7.5%
373	Extravasation of Diagnostic and Therapeutic Materials	7.4%
374	Neoplastic Processes	7.4%
375	Williams Syndrome	7.3%
376	Necrosis	7.2%
377	Granulomatosis, Orofacial	7.2%
378	Pigmentation Disorders	7.2%
379	Respiratory Aspiration	7.2%
380	Acantholysis	7.2%
381	Chromosome Aberrations	7.2%
382	Dehydration	7.2%
383	Granuloma	7.2%
384	Leukocytosis	7.2%
385	Pleocytosis	7.2%
386	Kartagener Syndrome	7.1%
387	Chromosomal Instability	6.7%
388	Dumping Syndrome	6.6%
389	Genomic Instability	6.4%
390	Muscle Weakness	6.3%
391	Azotemia	6.2%
392	Menorrhagia	6.2%
393	Dural Arteriovenous Fistula	5.9%
394	jaundice	5.7%
395	Cardiotoxicity	5.6%
396	Sudden infant death syndrome	5.6%
397	MELAS Syndrome	5.6%
398	Phantom pain	5.6%
399	Phantom Limb Pain	5.6%
400	Brain Hemorrhage, Traumatic	5.4%
401	Signs and Symptoms	5.1%
402	Pathological Conditions, Anatomical	5.1%
403	Eye Hemorrhage	5.1%
404	Hemoptysis	5%
405	Ecchymosis	5%
406	Petechiae	5%
407	Purpura	5%
408	Acute Disease	5%
409	Acute-Phase Reaction	5%
410	Amenorrhea	5%
411	Chronic disease	5%
412	Critical Illness	5%
413	Sudden death	5%
414	Fat necrosis	5%
415	Gangrene	5%
416	Granuloma, Plasma Cell	5%
417	Hematoma	5%
418	Iatrogenic Disease	5%
419	Multiple Organ Failure	5%
420	Oligomenorrhea	5%
421	Premenstrual syndrome	5%
422	Recurrence	5%
423	Retrograde Degeneration	5%
424	Retroperitoneal fibrosis	5%
425	Serositis	5%
426	Subcutaneous Emphysema	5%
427	Syndrome	5%
428	Wallerian Degeneration	5%
429	Pyogenic granuloma	5%
430	Exsanguination	5%
431	Disease Progression	5%
432	Seroma	5%
433	Premenstrual Tension	5%
434	Infant Death	5%
435	Intraoperative Awareness	5%
436	Dysmenorrhea	4.9%
437	Fabry Disease	4.5%
438	Epistaxis	4.5%
439	Asphyxia	4.4%
440	Granuloma, Respiratory Tract	4.4%
441	Shock, Traumatic	4.4%
442	Chromosome Fragility	4.4%
443	Endotoxic shock	4.3%
444	Septic Shock	4.3%
445	Toxic Shock Syndrome	4.3%
446	Disease susceptibility	4.3%
447	Fetal Death	4.3%
448	Foreign-Body Reaction	4.3%
449	Gastrointestinal Hemorrhage	4.3%
450	Hemarthrosis	4.3%
451	Hemoperitoneum	4.3%
452	Hemothorax	4.3%
453	Neoplasm Invasiveness	4.3%
454	Neoplasm Metastasis	4.3%
455	Neoplasm Recurrence, Local	4.3%
456	Injection Site Reaction	4.3%
457	Retrobulbar Hemorrhage	4.3%
458	Aseptic Necrosis of Bone	4.3%
459	Peritoneal Fibrosis	4.3%
460	Carcinogenesis	4.3%
461	Neurogenic Inflammation	4.3%
462	Perinatal death	4.3%
463	Infusion site reaction	4.3%
464	Nephrogenic Fibrosing Dermopathy	4.3%
465	Encapsulating Peritoneal Sclerosis	4.3%
466	Suppuration	4.3%
467	Nephrogenic Systemic Fibrosis	4.3%
468	Metastasis	4.3%
469	Dental Pulp Necrosis	4.3%
470	Granuloma, Foreign-Body	4.3%
471	Mediastinal Emphysema	4.3%
472	Facies	4.3%
473	Embryo Loss	4.3%
474	Sex Chromosome Aberrations	4.2%
475	Uterine hemorrhage	4.2%
476	Trisomy	3.9%
477	Drowning	3.8%
478	Fetal Growth Retardation	3.8%
479	DNA Degradation, Necrotic	3.8%
480	Jaundice, Obstructive	3.8%
481	Aneuploidy	3.7%
482	Polyploidy	3.7%
483	Microsatellite Instability	3.7%
484	Cicatrix	3.7%
485	Hematuria	3.7%
486	Granuloma Annulare	3.7%
487	Chromosome Breakage	3.7%
488	Brain Death	3.7%
489	Giant Cell Epulis	3.4%
490	Tissue Adhesions	3.3%
491	Hematoma, Epidural, Spinal	3.3%
492	Hematemesis	3.3%
493	Purpura Fulminans	3.3%
494	Micronuclei, Chromosome-Defective	3.3%
495	Subacute Combined Degeneration	3%
496	Eosinophilic Granuloma	3%
497	Cross Infection	2.9%
498	Hyphema	2.9%
499	Retinal Neovascularization	2.9%
500	Septicemia	2.9%
501	Vitreous Hemorrhage	2.9%
502	Sepsis	2.9%
503	Abscess	2.8%
504	Empyema	2.8%
505	Femur Head Necrosis	2.8%
506	Fetal Resorption	2.8%
507	Lymphatic Metastasis	2.8%
508	Neoplasms, Unknown Primary	2.8%
509	Peptic Ulcer Hemorrhage	2.8%
510	Leukemic Infiltration	2.8%
511	Premenstrual Dysphoric Disorder	2.8%
512	Choroidal Neovascularization	2.8%
513	Neoplasm Micrometastasis	2.8%
514	Cicatrix, Hypertrophic	2.8%
515	Metrorrhagia	2.8%
516	Asthenia	2.8%
517	Body Temperature Changes	2.8%
518	Calculi	2.8%
519	Cyanosis	2.8%
520	Edema	2.8%
521	Failure to Thrive	2.8%
522	Fatigue	2.8%
523	Feminization	2.8%
524	Fetal Distress	2.8%
525	Hernia	2.8%
526	Hypertrophy	2.8%
527	Motion Sickness	2.8%
528	Nails, Malformed	2.8%
529	polyps	2.8%
530	Rupture, Spontaneous	2.8%
531	Signs and Symptoms, Digestive	2.8%
532	Signs and Symptoms, Respiratory	2.8%
533	Skin Manifestations	2.8%
534	Chills	2.8%
535	Lassitude	2.8%
536	Enterocele	2.8%
537	Atheroma	2.8%
538	Pseudophakia	2.8%
539	Urological Manifestations	2.8%
540	Stenosis	2.8%
541	Facial asymmetry	2.8%
542	Mobility Limitation	2.8%
543	Somnolence	2.8%
544	Plaque, Amyloid	2.8%
545	Plaque, Atherosclerotic	2.8%
546	Kernicterus	2.7%
547	Thrombocytopenic purpura	2.7%
548	Renal Colic	2.6%
549	Retinal Hemorrhage	2.5%
550	Choroid Hemorrhage	2.5%
551	Melena	2.5%
552	Postpartum Hemorrhage	2.5%
553	Gingival Hemorrhage	2.5%
554	Keloid	2.5%
555	Hematoma, Subdural, Spinal	2.5%
556	Monosomy	2.5%
557	Tetraploidy	2.5%
558	Stillbirth	2.5%
559	Cyst	2.5%
560	Eye Manifestations	2.5%
561	Neurologic Manifestations	2.5%
562	Leukoplakia	2.4%
563	Reticulocytosis	2.4%
564	Airway Remodeling	2.4%
565	Ventricular Remodeling	2.4%
566	Alopecia	2.4%
567	Androgenetic Alopecia	2.4%
568	Abdominal Pain	2.4%
569	Cellulitis	2.2%
570	Viremia	2.2%
571	Parasitemia	2.2%
572	Hypergammaglobulinemia	2.1%
573	Eye pain	2.1%
574	Diverticulum	2.1%
575	Diverticulosis	2.1%
576	Muscular Atrophy	2.1%
577	Granuloma, Laryngeal	2%
578	Purpura, Thrombotic Thrombocytopenic	2%
579	Bacteremia	1.9%
580	Cell Transformation, Viral	1.9%
581	Waterhouse-Friderichsen Syndrome	1.9%
582	Fungemia	1.9%
583	Philadelphia Chromosome	1.8%
584	Anorexia	1.7%
585	Anoxia	1.7%
586	Constipation	1.7%
587	Diarrhea	1.7%
588	Dyspepsia	1.7%
589	Eructation	1.7%
590	Fever	1.7%
591	Flatulence	1.7%
592	Flushing	1.7%
593	Halitosis	1.7%
594	Heartburn	1.7%
595	Diaphragmatic Hernia	1.7%
596	Hiccough	1.7%
597	Hypercalciuria	1.7%
598	Hypercapnia	1.7%
599	Hyperphagia	1.7%
600	Intestinal Polyps	1.7%
601	Nausea	1.7%
602	Pallor	1.7%
603	Psychophysiologic Disorders	1.7%
604	Splenomegaly	1.7%
605	Vomiting	1.7%
606	Hypocapnia	1.7%
607	Dyschezia	1.7%
608	Hypoxia	1.7%
609	Hyperoxia	1.7%
610	Lower Urinary Tract Symptoms	1.7%
611	Hypoxemia	1.7%
612	Urinoma	1.7%
613	Autoimmune thrombocytopenia	1.7%
614	Immune thrombocytopenic purpura	1.7%
615	Body Weight	1.6%
616	Abdomen, Acute	1.6%
617	Endotoxemia	1.5%
618	Hoarseness	1.5%
619	Respiratory Tract Fistula	1.5%
620	Apnea	1.4%
621	Cheyne-Stokes Respiration	1.4%
622	Decerebrate State	1.4%
623	Dyspnea	1.4%
624	Hemiparesis	1.4%
625	Hepatomegaly	1.4%
626	Hyperventilation	1.4%
627	Meningism	1.4%
628	Mouth Breathing	1.4%
629	Paresis	1.4%
630	Parovarian Cyst	1.4%
631	Pruritus	1.4%
632	Seizures	1.4%
633	Sensation Disorders	1.4%
634	Sneezing	1.4%
635	Spermatocele	1.4%
636	Erythema	1.4%
637	Oral Fistula	1.4%
638	Complex partial seizures	1.4%
639	Necrolytic Migratory Erythema	1.4%
640	Tachypnea	1.4%
641	Monoparesis	1.4%
642	Cutaneous Fistula	1.4%
643	Gait Disorders, Neurologic	1.4%
644	Neuromuscular Manifestations	1.4%
645	Sarcopenia	1.4%
646	Mental Fatigue	1.4%
647	Hirsutism	1.4%
648	Orthostatic intolerance	1.4%
649	Hypoventilation	1.4%
650	Vaginal Fistula	1.4%
651	Rectocele	1.4%
652	Body Weight Changes	1.4%
653	Sleep Wake Disorders	1.3%
654	Pupil Disorders	1.3%
655	Neurobehavioral Manifestations	1.3%
656	Gait Ataxia	1.3%
657	Nasal Polyps	1.3%
658	Pleural Rub	1.3%
659	Rales	1.3%
660	Respiratory Sounds	1.3%
661	Rhonchi	1.3%
662	Stridor	1.3%
663	Wheezing	1.3%
664	Asterixis	1.3%
665	Ballismus	1.3%
666	Vertigo	1.3%
667	Pain	1.2%
668	Ache	1.2%
669	Meningocele	1.2%
670	Oliguria	1.2%
671	Polyuria	1.2%
672	Proteinuria	1.2%
673	Urinary Calculi	1.2%
674	Encephalocele	1.2%
675	Underweight	1.2%
676	Overweight	1.2%
677	Candidemia	1.2%
678	Akathisia	1.1%
679	Restlessness	1.1%
680	Psychomotor Agitation	1.1%
681	Vesicovaginal Fistula	1.1%
682	Voice Disorders	1.1%
683	Voice Disturbance	1.1%
684	Gagging	1.1%
685	Leukoplakia, Oral	1.1%
686	Back Pain	1.1%
687	Bulimia	1.1%
688	Neck Pain	1.1%
689	Chest Pain	1.1%
690	Colonic Polyps	1.1%
691	Dizziness	1.1%
692	Dysuria	1.1%
693	Facial Pain	1.1%
694	Fever of Unknown Origin	1.1%
695	Flank Pain	1.1%
696	Headache	1.1%
697	Nocturia	1.1%
698	Pain, Intractable	1.1%
699	Pelvic Pain	1.1%
700	Snoring	1.1%
701	Chronic pain	1.1%
702	Lightheadedness	1.1%
703	Pain, Referred	1.1%
704	Prostatism	1.1%
705	Throbbing Headache	1.1%
706	Labor Pain	1.1%
707	Cancer Pain	1.1%
708	Nociceptive Pain	1.1%
709	Gait Apraxia	1.1%
710	Jet Lag Syndrome	1%
711	Reflex, Abnormal	1%
712	Hyporeflexia	1%
713	Hyperreflexia	1%
714	Birth Weight	1%
715	Biliary Fistula	1%
716	Gastric Fistula	1%
717	Congenital diaphragmatic hernia	1%
718	Morning Sickness	1%
719	Anosmia	0.9%
720	Ataxia	0.9%
721	Athetosis	0.9%
722	Catalepsy	0.9%
723	Dental Fistula	0.9%
724	Dystonia	0.9%
725	Hemiplegia	0.9%
726	Locked-In Syndrome	0.9%
727	Muscle Hypertonia	0.9%
728	Muscle hypotonia	0.9%
729	Myoclonus	0.9%
730	Myotonia	0.9%
731	Neuralgia	0.9%
732	Oroantral Fistula	0.9%
733	Paraplegia	0.9%
734	Pseudobulbar Palsy	0.9%
735	Quadriplegia	0.9%
736	Spasm	0.9%
737	Spastic Paraplegia	0.9%
738	Status Epilepticus	0.9%
739	Taste Disorders	0.9%
740	Tremor	0.9%
741	Monoplegia	0.9%
742	Hypokinesia	0.9%
743	Gastroparesis	0.9%
744	Paraparesis	0.9%
745	Bradykinesia	0.9%
746	Waxy flexibility	0.9%
747	Action Tremor	0.9%
748	Resting Tremor	0.9%
749	Dysosmia	0.9%
750	Quadriparesis	0.9%
751	Olfaction Disorders	0.9%
752	Myokymia	0.9%
753	Somatosensory Disorders	0.9%
754	Neuropathic pain	0.9%
755	Hyperkinesia	0.9%
756	Intention tremor	0.9%
757	Rectal Prolapse	0.9%
758	Uterine Prolapse	0.9%
759	Vaginal Prolapse	0.9%
760	Weight Gain	0.9%
761	Alice in Wonderland Syndrome	0.9%
762	Vision Disorders	0.8%
763	Metamorphopsia	0.8%
764	Visual Impairment	0.8%
765	Bronchial Fistula	0.8%
766	Metatarsalgia	0.8%
767	Pancreatic Fistula	0.8%
768	Anisocoria	0.8%
769	Confusion	0.8%
770	Facial paralysis	0.8%
771	Intestinal Fistula	0.8%
772	Lethargy	0.8%
773	Memory Disorders	0.8%
774	Muscle Cramp	0.8%
775	Perceptual Disorders	0.8%
776	Psychomotor Disorders	0.8%
777	Tonic Pupil	0.8%
778	Anhedonia	0.8%
779	Disorientation	0.8%
780	Gastroschisis	0.8%
781	Enterocutaneous Fistula	0.8%
782	Fetal Hypoxia	0.8%
783	Facial Paresis	0.8%
784	Memory Loss	0.8%
785	Hemisensory Neglect	0.8%
786	Dysacusis	0.8%
787	Hydrops Fetalis	0.8%
788	Mastodynia	0.8%
789	Respiratory Paralysis	0.8%
790	Salivary Gland Fistula	0.8%
791	Chorea	0.8%
792	Cystocele	0.8%
793	Tetany	0.8%
794	Urinary Incontinence	0.8%
795	Breakthrough Pain	0.8%
796	Emaciation	0.8%
797	Low Back Pain	0.8%
798	Visceral Pain	0.8%
799	Albuminuria	0.8%
800	Hemoglobinuria	0.8%
801	Fetal Weight	0.8%
802	Alexia	0.8%
803	Dyslexia	0.8%
804	Consciousness Disorders	0.7%
805	Mental Retardation	0.7%
806	Depressed Level of Consciousness	0.7%
807	Mental deficiency	0.7%
808	Intellectual Disability	0.7%
809	Catatonia	0.7%
810	Musculoskeletal Pain	0.7%
811	Ophthalmoplegia	0.7%
812	External Ophthalmoplegia	0.7%
813	Aphonia	0.7%
814	Arthralgia	0.7%
815	Sleep Deprivation	0.7%
816	Polyarthralgia	0.7%
817	Dysphonia	0.7%
818	Cerebrospinal Fluid Otorrhea	0.7%
819	Cerebrospinal Fluid Rhinorrhea	0.7%
820	Obesity	0.7%
821	Umbilical hernia	0.7%
822	Toothache	0.7%
823	Hyperemesis Gravidarum	0.7%
824	Dysgeusia	0.7%
825	Formication	0.7%
826	Hyperalgesia	0.7%
827	Hyperesthesia	0.7%
828	Hypesthesia	0.7%
829	Language Disorders	0.7%
830	Numbness	0.7%
831	Paresthesia	0.7%
832	Paraparesis, Spastic	0.7%
833	Trismus	0.7%
834	Epilepsia Partialis Continua	0.7%
835	Hypogeusia	0.7%
836	Brown-Sequard Syndrome	0.7%
837	Lockjaw	0.7%
838	Allodynia	0.7%
839	Ageusia	0.7%
840	Cachexia	0.7%
841	Vocal Cord Paralysis	0.7%
842	Urinary Bladder Fistula	0.7%
843	Tinea Pedis	0.7%
844	Diplopia	0.6%
845	Muscle Rigidity	0.6%
846	Muscle Spasticity	0.6%
847	Scotoma	0.6%
848	Photophobia	0.6%
849	Cogwheel Rigidity	0.6%
850	Hemifacial Spasm	0.6%
851	Amaurosis	0.6%
852	Blindness	0.6%
853	Nuchal Rigidity	0.6%
854	Agnosia	0.6%
855	Apraxias	0.6%
856	Hallucinations	0.6%
857	Hemianopsia	0.6%
858	Hyperacusis	0.6%
859	Tinnitus	0.6%
860	Visual Agnosia	0.6%
861	Anosognosia	0.6%
862	Wernicke-Korsakoff Syndrome	0.6%
863	Phonophobia	0.6%
864	Hearing Loss	0.6%
865	Cerebellar Ataxia	0.6%
866	Torticollis	0.6%
867	Sciatica	0.6%
868	Urge Incontinence	0.6%
869	Tardive Dyskinesia	0.6%
870	Dyskinesia, Drug-Induced	0.6%
871	Alcohol Withdrawal Seizures	0.6%
872	Agraphia	0.6%
873	Anomia	0.6%
874	Cluttering	0.6%
875	Language Development Disorders	0.6%
876	Speech Disorders	0.6%
877	Syncope	0.6%
878	Stupor	0.6%
879	Dysgraphia	0.6%
880	Presyncope	0.6%
881	Dyslalia	0.6%
882	Amblyopia	0.6%
883	Amnesia	0.6%
884	Delirium	0.6%
885	Horner Syndrome	0.6%
886	Dissociative Amnesia	0.6%
887	Color blindness	0.6%
888	Global Amnesia	0.6%
889	Rectal Fistula	0.5%
890	Anal Fistula	0.5%
891	Shoulder Pain	0.5%
892	Kidney Calculi	0.5%
893	Ureteral Calculi	0.5%
894	Pediatric Obesity	0.5%
895	Aphasia	0.5%
896	Articulation Disorders	0.5%
897	Echolalia	0.5%
898	Stuttering	0.5%
899	Dysphasia	0.5%
900	Amaurosis Fugax	0.5%
901	Blindness, Cortical	0.5%
902	Dyscalculia	0.5%
903	Deafness	0.5%
904	Hearing Loss, Sudden	0.5%
905	Gerstmann Syndrome	0.5%
906	Hearing Loss, Bilateral	0.5%
907	Hearing Loss, High-Frequency	0.5%
908	Hearing Loss, Mixed Conductive-Sensorineural	0.5%
909	Prosopagnosia	0.5%
910	Apraxia, Ideomotor	0.5%
911	Persistent Vegetative State	0.5%
912	Charles Bonnet Syndrome	0.5%
913	Hearing Loss, Unilateral	0.5%
914	Complete Hearing Loss	0.5%
915	Alien Hand Syndrome	0.5%
916	Deaf Mutism	0.5%
917	Akathisia, Drug-Induced	0.5%
918	Myalgia	0.5%
919	Dysarthria	0.5%
920	Mutism	0.5%
921	Selective Mutism	0.5%
922	Retrograde amnesia	0.5%
923	Amnesia, Anterograde	0.5%
924	Auditory Perceptual Disorders	0.4%
925	Alexia, Pure	0.4%
926	Ophthalmoplegic Migraine	0.4%
927	Progressive supranuclear palsy	0.4%
928	Amnesia, Transient Global	0.4%

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