MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mitochondrial Encephalomyopathies

(UMLS:C0162666)

Definition:: A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)
UMLS ID:: C0162666
MeSH ID:: D017237

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.651.460.620

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.540|C10.668.491.500.500

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.540|C18.452.660.560.620

Synonym(s)

Mitochondrial Encephalomyopathies

Mitochondrial encephalomyopathy

Mitochondrial myoencephalopathy

encephalomyopathies mitochondrial

mitochondrial encephalomyopathy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Leucovorin		18058625	CTD
2	Ubiquinone Q2		18058625	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Brain Diseases, Metabolic, Inborn	32.8%
2	Myelinolysis, Central Pontine	32.6%
3	Leigh Disease	30%
4	Reye Syndrome	28.3%
5	Hepatic Encephalopathy	28.2%
6	Carbamoyl-Phosphate Synthase I Deficiency Disease	26.6%
7	Kearns-Sayre syndrome	24.6%
8	Adrenoleukodystrophy	24%
9	Galactosemias	23.9%
10	Urea Cycle Disorders, Inborn	23.9%
11	Tyrosinemias	23.9%
12	Wernicke Encephalopathy	23.6%
13	Hepatolenticular Degeneration	23.5%
14	Homocystinuria	21.2%
15	Wasting Syndrome	21.1%
16	Familial Periodic Paralysis	20.9%
17	Kernicterus	20.8%
18	Fibromyalgia	20.1%
19	MELAS Syndrome	20%
20	Pseudohypoparathyroidism	20%
21	Myositis	19.9%
22	Myotonic Disorders	19.9%
23	Marchiafava-Bignami Disease	19.8%
24	Hypercalcemia	19.7%
25	Hypocalcemia	19.7%
26	Milk-Alkali Syndrome	19.7%
27	Refsum Disease	19.6%
28	Canavan Disease	19.5%
29	Alexander Disease	19.5%
30	Glycogen storage disease type II	19.2%
31	Chronic Fatigue Syndrome	19%
32	Osteopenia	18.7%
33	Friedreich Ataxia	18.5%
34	Gaucher Disease	18.5%
35	Acid-Base Imbalance	18.2%
36	Calcium Metabolism Disorders	18.2%
37	Iron Metabolism Disorders	18.2%
38	Phosphorus Metabolism Disorders	18.2%
39	Water-Electrolyte Imbalance	18.2%
40	Lipid Metabolism Disorders	18.2%
41	Glucose Metabolism Disorders	18.2%
42	Menkes Kinky Hair Syndrome	18.1%
43	Rickets	18%
44	Zellweger Syndrome	17.7%
45	Medial Tibial Stress Syndrome	17.6%
46	Fabry Disease	17.5%
47	Meningoencephalitis	17.5%
48	Eosinophilia-Myalgia Syndrome	17.4%
49	Lipodystrophy	17.3%
50	Amyotrophic Lateral Sclerosis	16.8%
51	Tay-Sachs Disease	16.3%
52	Multiple System Atrophy	16.2%
53	Niemann-Pick Disease, Type C	15.9%
54	Dementia, Vascular	15.6%
55	Stiff-Person Syndrome	15.6%
56	Cytochrome-c Oxidase Deficiency	15.5%
57	Dandy-Walker Syndrome	15.4%
58	Encephalomyelitis	15.2%
59	Lewy Body Disease	15.1%
60	Myotonic Dystrophy	15%
61	Subdural Effusion	15%
62	Familial Hypophosphatemic Rickets	14.6%
63	Pneumocephalus	14.6%
64	Hypokalemic periodic paralysis	14.4%
65	Amyloid Neuropathies, Familial	14.4%
66	Motor Neuron Disease	14.4%
67	Hyperhomocysteinemia	14.3%
68	Isaacs syndrome	14.2%
69	Myalgia	13.8%
70	Smith-Lemli-Opitz Syndrome	13.3%
71	Brain Abscess	13.2%
72	Poliomyelitis	13.1%
73	Akinetic Mutism	13.1%
74	Anoxic Encephalopathy	13.1%
75	Basal Ganglia Diseases	13.1%
76	Brain Damage, Chronic	13.1%
77	Cerebellar Diseases	13.1%
78	Encephalitis	13.1%
79	Encephalomalacia	13.1%
80	Epilepsy	13.1%
81	Hydrocephalus	13.1%
82	Congenital Hydrocephalus	13.1%
83	Hypothalamic Diseases	13.1%
84	Thalamic Diseases	13.1%
85	Intracranial Hypertension	13.1%
86	Aura	13.1%
87	Leukoencephalopathy	13.1%
88	Neuroaxonal Dystrophies	13.1%
89	Headache Disorders	13.1%
90	Intracranial Hypotension	13.1%
91	Brain Edema	13.1%
92	Brain Hypoxia	13.1%
93	Aqueductal Stenosis	13.1%
94	Polymyositis	13.1%
95	Parkinsonian Disorders	13.1%
96	Basal Ganglia Cerebrovascular Disease	13.1%
97	Osteomalacia	13%
98	Lactose Intolerance	13%
99	Epilepsy, Post-Traumatic	13%
100	Posterior Leukoencephalopathy Syndrome	13%
101	Posterior reversible encephalopathy syndrome	13%
102	Hyperlipoproteinemia Type IV	12.9%
103	Hyperlipoproteinemia Type V	12.9%
104	Ocular Motility Disorders	12.9%
105	Cyclophoria	12.9%
106	Myotonia Congenita	12.4%
107	Spinal Muscular Atrophy	12.3%
108	Brain Injuries	12.3%
109	Progressive Muscular Atrophy	12.3%
110	Parkinson Disease	12.3%
111	Brain Neoplasms	12.3%
112	Hypolipoproteinemias	12.2%
113	Hyperphosphaturia	12.1%
114	Ataxia Telangiectasia	12.1%
115	Huntington Disease	12%
116	Osteoporosis	11.7%
117	Bone Demineralization, Pathologic	11.7%
118	Post-Traumatic Osteoporosis	11.7%
119	Subacute Combined Degeneration	11.7%
120	Leukomalacia, Periventricular	11.6%
121	Epidural Abscess	11.6%
122	Muscular Dystrophy	11.6%
123	Orbital Myositis	11.6%
124	Contracture	11.5%
125	Acidosis	11.5%
126	Alkalosis	11.5%
127	Amyloidosis	11.5%
128	Calcinosis	11.5%
129	Hyperglycemia	11.5%
130	Hyperinsulinism	11.5%
131	Hyperkalemia	11.5%
132	Hypernatremia	11.5%
133	Hypoglycemia	11.5%
134	Hypokalemia	11.5%
135	Hyponatremia	11.5%
136	Xanthomatosis	11.5%
137	Hypophosphatemia	11.5%
138	Metabolic acidosis	11.5%
139	Dyslipidemias	11.5%
140	Iron Overload	11.5%
141	Xanthoma	11.5%
142	Pyomyositis	11.5%
143	Progressive supranuclear palsy	11.4%
144	Vascular Headaches	11.4%
145	Cerebrovascular Disorders	11.4%
146	Cerebrovascular Insufficiency	11.4%
147	Dementia	11.4%
148	Hypoxia-Ischemia, Brain	11.4%
149	Leukoencephalopathy, Progressive Multifocal	11.4%
150	Myelitis	11.3%
151	Arthrogryposis	11.2%
152	Meige Syndrome	11.2%
153	Cerebral Ventriculitis	11.2%
154	Cerebellar Neoplasms	11.1%
155	Myoclonic Epilepsy	11.1%
156	Epilepsy, Temporal Lobe	11.1%
157	Epilepsy, Rolandic	11.1%
158	Benign Rolandic Epilepsy	11.1%
159	Congenital Hyperinsulinism	11.1%
160	Meningitis	11%
161	Movement Disorders	11%
162	Pachymeningitis	11%
163	Spinal Cord Diseases	11%
164	Neuromuscular Junction Diseases	11%
165	Peripheral Nervous System Diseases	11%
166	Diabetic Ketoacidosis	11%
167	Hyperlipidemia, Familial Combined	11%
168	Dystonia Musculorum Deformans	10.9%
169	Optic Atrophy, Hereditary, Leber	10.9%
170	Striatonigral Degeneration	10.8%
171	Brain Death	10.8%
172	Miller Fisher Syndrome	10.8%
173	Neuronal Ceroid-Lipofuscinoses	10.7%
174	Neuroleptic Malignant Syndrome	10.7%
175	Nutrition Disorders	10.7%
176	Lupus Vasculitis, Central Nervous System	10.6%
177	Leukoencephalitis, Acute Hemorrhagic	10.5%
178	Ophthalmoplegic Migraine	10.4%
179	Prion Diseases	10.4%
180	Complex Regional Pain Syndromes	10.4%
181	Polyradiculoneuropathy	10.4%
182	Polyradiculoneuritis	10.4%
183	Hyperlipoproteinemia Type III	10.3%
184	Ischemic contracture	10.3%
185	Amblyopia	10.2%
186	Cranial nerve diseases	10.2%
187	Demyelinating Diseases	10.2%
188	Demyelination	10.2%
189	Chronobiology Disorders	10.2%
190	Diabetes Mellitus	10.1%
191	Cerebral Amyloid Angiopathy	10.1%
192	Frontotemporal dementia	10.1%
193	Polymyalgia Rheumatica	10%
194	Dehydration	10%
195	Lipomatosis	10%
196	Water Intoxication	10%
197	Werner Syndrome	10%
198	Basal Ganglia Hemorrhage	9.9%
199	Myofascial Pain Syndromes	9.9%
200	Rhabdomyolysis	9.9%
201	Mitochondrial Diseases	9.9%
202	Muscle Cramp	9.9%
203	Achlorhydria	9.9%
204	Amino Acid Metabolism, Inborn Errors	9.9%
205	Bloom Syndrome	9.9%
206	Carbohydrate Metabolism, Inborn Errors	9.9%
207	Metal Metabolism, Inborn Errors	9.9%
208	Progeria	9.9%
209	Lysosomal Storage Diseases	9.9%
210	Peroxisomal Disorders	9.9%
211	Guillain-Barre Syndrome	9.8%
212	Celiac Disease	9.8%
213	Sprue, Tropical	9.8%
214	Steatorrhea	9.8%
215	Sprue	9.8%
216	Limbic Encephalitis	9.8%
217	Renal Osteodystrophy	9.8%
218	Renal rickets	9.8%
219	Creutzfeldt-Jakob disease	9.8%
220	Shy-Drager Syndrome	9.8%
221	Central Nervous System Infection	9.8%
222	Renal tubular acidosis	9.7%
223	Hypoalphalipoproteinemias	9.7%
224	Gout	9.6%
225	MPTP Poisoning	9.5%
226	Restless Legs Syndrome	9.4%
227	Spinal Cord Injuries	9.4%
228	Juvenile Myoclonic Epilepsy	9.2%
229	Myoclonic Epilepsies, Progressive	9.2%
230	Peripheral Nerve Injuries	9.2%
231	Pituitary Adenoma	9.2%
232	Pituitary Neoplasms	9.2%
233	HIV Wasting Syndrome	9.2%
234	Brain Hemorrhage, Traumatic	9.2%
235	Myasthenia Gravis	9.1%
236	Asterixis	9.1%
237	Ballismus	9.1%
238	Muscle Rigidity	9%
239	Muscle Spasticity	9%
240	Cogwheel Rigidity	9%
241	Nuchal Rigidity	9%
242	Presenile dementia	9%
243	Senile dementia	9%
244	Cockayne Syndrome	9%
245	Causalgia	9%
246	Trauma, Nervous System	9%
247	Muscle Weakness	8.9%
248	Carotid Artery Injuries	8.9%
249	HIV-Associated Lipodystrophy Syndrome	8.9%
250	Amnesia, Transient Global	8.8%
251	Nervous System Neoplasms	8.8%
252	Neurologic Manifestations	8.8%
253	Neurotoxicity Syndromes	8.8%
254	Pituitary Apoplexy	8.7%
255	Encephalomyelitis, Acute Disseminated	8.7%
256	Cerebral Palsy	8.7%
257	Epilepsies, Partial	8.7%
258	Epilepsy, Generalized	8.7%
259	Nesidioblastosis	8.7%
260	Pseudotumor Cerebri	8.7%
261	Hypertensive Encephalopathy	8.7%
262	Simple Partial Seizures	8.7%
263	Epilepsy, Reflex	8.7%
264	Headache Disorders, Primary	8.7%
265	Headache Disorders, Secondary	8.7%
266	Medication overuse headache	8.7%
267	Lafora Disease	8.7%
268	Unverricht-Lundborg Syndrome	8.7%
269	Brain Infarction	8.6%
270	Compartment syndromes	8.6%
271	Tendinitis	8.6%
272	Tendinopathy	8.6%
273	Vasculitis, Central Nervous System	8.6%
274	Glycosuria	8.6%
275	Tetany	8.6%
276	Myelitis, Transverse	8.6%
277	Welander Distal Myopathy	8.6%
278	Brain Diseases, Metabolic	8.5%
279	Progressive bulbar palsy	8.5%
280	Bulbar palsy	8.5%
281	Putaminal Hemorrhage	8.4%
282	Lambert-Eaton Myasthenic Syndrome	8.4%
283	Osteoporosis, Postmenopausal	8.4%
284	Temporomandibular Joint Dysfunction Syndrome	8.2%
285	Meningitis, Bacterial	8.2%
286	Meningitis, Fungal	8.2%
287	Acidosis, Lactic	8.2%
288	Calciphylaxis	8.2%
289	Hemosiderosis	8.2%
290	Ketosis	8.2%
291	Ketonuria	8.2%
292	Ketoacidosis	8.2%
293	Ketonemia	8.2%
294	Vascular calcification	8.2%
295	Infarction, Middle Cerebral Artery	8.2%
296	Infarction, Anterior Cerebral Artery	8.2%
297	Infarction, Posterior Cerebral Artery	8.2%
298	Toxoplasmosis, Cerebral	8.1%
299	Brain Injuries, Diffuse	8.1%
300	Traumatic Brain Injury	8.1%
301	Cerebellar Ataxia	8.1%
302	Supratentorial Neoplasms	8.1%
303	Botulism	8.1%
304	Glycosuria, Renal	8.1%
305	Paraneoplastic Cerebellar Degeneration	8%
306	Sleep Wake Disorders	7.8%
307	Porphyrias, Hepatic	7.7%
308	Mucopolysaccharidosis III	7.7%
309	Dermatomyositis	7.7%
310	Opsoclonus-Myoclonus Syndrome	7.7%
311	Pituitary Diseases	7.7%
312	Persistent Vegetative State	7.7%
313	Necrobiosis Lipoidica Diabeticorum	7.7%
314	Muscular Dystrophy, Duchenne	7.6%
315	Fanconi Anemia	7.6%
316	Autonomic Dysreflexia	7.6%
317	Hip Contracture	7.5%
318	Carotid Artery Diseases	7.5%
319	Brain Ischemia	7.5%
320	Cerebrovascular accident	7.5%
321	Kluver-Bucy Syndrome	7.5%
322	Vasospasm, Intracranial	7.5%
323	Intracranial Arterial Diseases	7.5%
324	Brachial Plexus Neuritis	7.4%
325	Neuralgic Amyotrophy	7.4%
326	Spinal Cord Neoplasms	7.4%
327	Akathisia, Drug-Induced	7.3%
328	Dyskinesia, Drug-Induced	7.3%
329	Mitochondrial Encephalomyopathies	7.2%
330	Cerebral Infarction	7.2%
331	Brain Stem Infarctions	7.2%
332	Arthritis, Gouty	7.1%
333	Moyamoya Disease	7.1%
334	Temporomandibular Joint Disorders	7.1%
335	Acidosis, Respiratory	7%
336	Adiposis Dolorosa	7%
337	Alkalosis, Respiratory	7%
338	Antley-Bixler Syndrome Phenotype	7%
339	Alkaptonuria	7%
340	Glycogen Storage Disease	7%
341	Hypophosphatasia	7%
342	Insulin Resistance	7%
343	Propionic acidemia	7%
344	Dihydropyrimidine Dehydrogenase Deficiency	7%
345	Cystinosis	7%
346	Mucopolysaccharidosis II	6.7%
347	Musculoskeletal Pain	6.6%
348	Arachnoiditis	6.6%
349	Fibrodysplasia Ossificans Progressiva	6.6%
350	Aseptic Meningitis	6.6%
351	Myoglobinuria	6.6%
352	Myositis Ossificans	6.6%
353	Neuritis	6.6%
354	Polyneuritis	6.6%
355	Radiculitis	6.6%
356	Syringomyelia	6.6%
357	Tenosynovitis	6.6%
358	Polyneuropathy	6.6%
359	Mononeuritis	6.6%
360	Essential Tremor	6.6%
361	Familial Tremor	6.6%
362	Mononeuropathies	6.6%
363	Brachial Plexus Neuropathies	6.6%
364	Radiculopathy	6.6%
365	Mononeuropathy Multiplex	6.6%
366	Nerve Root Compression	6.6%
367	Pneumorrhachis	6.6%
368	Writer's Cramp	6.6%
369	Reflex Sympathetic Dystrophy	6.5%
370	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.5%
371	Intracranial Embolism and Thrombosis	6.5%
372	Acrodynia	6.5%
373	Hypercholesterolemia	6.5%
374	Hyperlipoproteinemias	6.5%
375	Hypertriglyceridemia	6.5%
376	Post-Traumatic Headache	6.5%
377	Tension Headache	6.5%
378	Epilepsy, Complex Partial	6.5%
379	Migraine Disorders	6.5%
380	Abdominal Migraine	6.5%
381	Status Migrainosus	6.5%
382	Cervicogenic Headache	6.5%
383	Tarsal Tunnel Syndrome	6.5%
384	Cauda Equina Syndrome	6.5%
385	Tuberculosis, Meningeal	6.5%
386	Subarachnoid Hemorrhage, Traumatic	6.4%
387	Carotid Artery, Internal, Dissection	6.4%
388	Lateral Medullary Syndrome	6.4%
389	Sjogren-Larsson Syndrome	6.3%
390	Gestational Diabetes	6.2%
391	Latent Autoimmune Diabetes in Adults	6.2%
392	Mitochondrial Myopathies	6.2%
393	Diabetes Mellitus, Experimental	6.2%
394	Nephrocalcinosis	6.1%
395	Child Nutrition Disorders	6.1%
396	Hypervitaminosis A	6.1%
397	Infant Nutrition Disorders	6.1%
398	Malnutrition	6.1%
399	Diffuse Axonal Injury	6.1%
400	Brain Stem Neoplasms	6.1%
401	Sleep Disorders, Circadian Rhythm	6%
402	Neuromyelitis Optica	6%
403	Subacute Sclerosing Panencephalitis	6%
404	Myasthenia Gravis, Autoimmune, Experimental	5.9%
405	Auditory Perceptual Disorders	5.9%
406	Central Nervous System Cysts	5.9%
407	Vertebral Artery Dissection	5.9%
408	Olfactory Nerve Injuries	5.8%
409	Scrapie	5.8%
410	Central Cord Syndrome	5.8%
411	Osteoarthropathy, Secondary Hypertrophic	5.7%
412	Fasciitis, Plantar	5.7%
413	Acromegaly	5.7%
414	Chorea	5.7%
415	Carpal Tunnel Syndrome	5.7%
416	Central Nervous System Fungal Infections	5.7%
417	Conus Medullaris Syndrome	5.7%
418	Myasthenic Syndromes, Congenital	5.7%
419	Spinal Cord Vascular Diseases	5.7%
420	Sciatica	5.7%
421	Bone Diseases	5.6%
422	Fasciitis	5.6%
423	Foot Deformities	5.6%
424	Arthropathy	5.6%
425	Empty Sella Syndrome	5.6%
426	Hyperpituitarism	5.6%
427	Hypopituitarism	5.6%
428	Hypophysitis	5.6%
429	Anterior Compartment Syndrome	5.6%
430	Diabetic Neuropathies	5.6%
431	Enthesopathy	5.6%
432	Diabetic Amyotrophy	5.6%
433	Diabetic Autonomic Neuropathy	5.6%
434	Abdominal Compartment Syndrome	5.6%
435	Neuralgia	5.6%
436	Neuropathic pain	5.6%
437	Brain Concussion	5.6%
438	Cerebral Arterial Diseases	5.6%
439	Vertebrobasilar Insufficiency	5.6%
440	Basilar Artery Stenosis	5.6%
441	Vertebral Artery Stenosis	5.6%
442	Intracranial Hemorrhage, Hypertensive	5.6%
443	Transient Cerebral Ischemia	5.6%
444	Glycogen Storage Disease Type I	5.6%
445	Glycogen Storage Disease Type V	5.6%
446	Dysautonomia	5.5%
447	Vagus Nerve Disorder	5.5%
448	Glossopharyngeal Neuralgia	5.5%
449	Abducens Nerve Diseases	5.5%
450	Heavy Metal Poisoning, Nervous System	5.5%
451	Tauopathies	5.5%
452	Trochlear Nerve Diseases	5.5%
453	Primary amyloidosis	5.5%
454	Variegate Porphyria	5.4%
455	Acute intermittent porphyria	5.4%
456	Porphyria Cutanea Tarda	5.4%
457	Cluster Headache	5.4%
458	Migraine with Aura	5.4%
459	Familial Hemiplegic Migraine	5.4%
460	Chronic Paroxysmal Hemicrania	5.4%
461	SUNCT Syndrome	5.4%
462	Paroxysmal Hemicrania	5.4%
463	Renal Aminoacidurias	5.4%
464	Fanconi Syndrome	5.4%
465	Pseudohypoaldosteronism	5.4%
466	Brain Contusion	5.4%
467	Liddle Syndrome	5.4%
468	Xeroderma Pigmentosum	5.4%
469	Pectus carinatum	5.4%
470	Alice in Wonderland Syndrome	5.3%
471	Facial Nerve Injuries	5.2%
472	AIDS Dementia Complex	5.2%
473	Charcot-Marie-Tooth Disease	5.2%
474	Horner Syndrome	5.1%
475	Hand-Arm Vibration Syndrome	5.1%
476	Neuromuscular Diseases	5.1%
477	Neuritis, Autoimmune, Experimental	5.1%
478	Meningitis, Cryptococcal	5.1%
479	Meningitis, Listeria	5%
480	Meningitis, Haemophilus	5%
481	Meningitis, Pneumococcal	5%
482	Choroid Plexus Papilloma	5%
483	Osteochondritis	5%
484	Central Nervous System Bacterial Infections	5%
485	Metatarsalgia	5%
486	Jaw Diseases	5%
487	Dupuytren Contracture	4.9%
488	Multiple Sclerosis	4.9%
489	Carotid Stenosis	4.9%
490	Intracranial Aneurysm	4.9%
491	Giant Cell Arteritis	4.9%
492	Temporal Arteritis	4.9%
493	Cartilage Diseases	4.9%
494	Foot Diseases	4.9%
495	Rheumatism	4.9%
496	Chondromalacia	4.9%
497	Optic Neuropathy	4.9%
498	Intracranial Arteriosclerosis	4.9%
499	Cerebral Atherosclerosis	4.9%
500	Subarachnoid Hemorrhage	4.9%
501	Torticollis	4.9%
502	Cerebral Arteriosclerosis	4.9%
503	Cerebral Hemorrhage	4.9%
504	Cerebral Thrombosis	4.9%
505	Cubital Tunnel Syndrome	4.9%
506	Intracranial Embolism	4.9%
507	Intracranial Thrombosis	4.9%
508	Tuberous Sclerosis	4.8%
509	Facial Nerve Diseases	4.8%
510	Craniocerebral Trauma	4.8%
511	Parasomnia	4.8%
512	Dyssomnias	4.8%
513	West Nile Fever	4.7%
514	Vestibulocochlear Nerve Diseases	4.7%
515	Decerebrate State	4.7%
516	Hemiparesis	4.7%
517	Hydranencephaly	4.7%
518	Meningism	4.7%
519	Neural Tube Defects	4.7%
520	Paresis	4.7%
521	Seizures	4.7%
522	Sensation Disorders	4.7%
523	Tethered Cord Syndrome	4.7%
524	Central Nervous System Neoplasms	4.7%
525	Complex partial seizures	4.7%
526	Iniencephaly	4.7%
527	Craniorachischisis	4.7%
528	Exencephaly	4.7%
529	Monoparesis	4.7%
530	Septo-Optic Dysplasia	4.7%
531	Cortical Dysplasia	4.7%
532	Neurogenic Inflammation	4.7%
533	Gait Disorders, Neurologic	4.7%
534	Neuromuscular Manifestations	4.7%
535	Malformations of Cortical Development	4.7%
536	Sweating, Gustatory	4.7%
537	Auriculotemporal Syndrome	4.7%
538	Nocturnal Myoclonus Syndrome	4.7%
539	Hyperprolactinemia	4.7%
540	Subclavian Steal Syndrome	4.6%
541	Pick Disease of the Brain	4.6%
542	Jet Lag Syndrome	4.6%
543	Osteoarthritis, Spine	4.5%
544	CREST Syndrome	4.4%
545	Ophthalmoplegia	4.4%
546	External Ophthalmoplegia	4.4%
547	Platybasia	4.4%
548	Sciatic Neuropathy	4.3%
549	Ulnar Neuropathies	4.3%
550	Lesion of Sciatic Nerve	4.3%
551	Ulnar Neuritis	4.3%
552	Radial nerve compression	4.3%
553	Radial Tunnel Syndrome	4.3%
554	Peroneal Neuropathies	4.3%
555	Radial Neuropathy	4.3%
556	Median Neuropathy	4.3%
557	Sciatic Nerve Palsy	4.3%
558	Femoral Neuropathy	4.3%
559	Tibial Neuropathy	4.3%
560	Ulnar Nerve Palsy	4.3%
561	Radial nerve palsy	4.3%
562	Carotid Artery Thrombosis	4.3%
563	Cystinuria	4.3%
564	Pupil Disorders	4.3%
565	Neurobehavioral Manifestations	4.3%
566	Paraneoplastic Encephalomyelitis	4.2%
567	Uveomeningoencephalitic Syndrome	4.1%
568	Pectus excavatum	4.1%
569	Rheumatic Fever	4.1%
570	Sturge-Weber Syndrome	4.1%
571	Vertigo	4.1%
572	Alcohol-Induced Disorders, Nervous System	4.1%
573	Albinism	4.1%
574	Hematoma, Subdural	4.1%
575	Hematoma, Epidural, Cranial	4.1%
576	neurofibroma	4.1%
577	Tardive Dyskinesia	4%
578	Sinus Thrombosis, Intracranial	4%
579	Vocal Cord Paralysis	4%
580	Deficiency Diseases	3.8%
581	Starvation	3.8%
582	Refeeding Syndrome	3.8%
583	Talipes	3.8%
584	Thoracic Outlet Syndrome	3.8%
585	Periarthritis	3.8%
586	Voice Disorders	3.7%
587	Voice Disturbance	3.7%
588	Spinal Cord Ischemia	3.7%
589	Alstrom Syndrome	3.7%
590	Klippel-Feil Syndrome	3.7%
591	Synostosis	3.7%
592	Rheumatoid Arthritis	3.7%
593	Juvenile arthritis	3.7%
594	Tuberculosis, Central Nervous System	3.7%
595	Smith-Magenis syndrome	3.7%
596	Dural Arteriovenous Fistula	3.7%
597	Cerebrospinal Fluid Otorrhea	3.6%
598	Cerebrospinal Fluid Rhinorrhea	3.6%
599	Cavernous Sinus Thrombosis	3.6%
600	Sagittal Sinus Thrombosis	3.6%
601	Gait Ataxia	3.6%
602	Alcohol Withdrawal Seizures	3.6%
603	Ankylosing spondylitis	3.6%
604	Acrocephalosyndactylia	3.5%
605	Ichthyosis, X-Linked	3.5%
606	Hematoma, Subdural, Intracranial	3.5%
607	Hematoma, Subdural, Chronic	3.5%
608	Hematoma, Subdural, Acute	3.5%
609	Coma, Post-Head Injury	3.5%
610	Craniosynostosis	3.4%
611	Syndactyly	3.4%
612	Brachycephaly	3.4%
613	Arthritis	3.3%
614	Bone Diseases, Developmental	3.3%
615	Bursitis	3.3%
616	Hyperostosis	3.3%
617	Joint Instability	3.3%
618	Osteitis	3.3%
619	Osteitis Deformans	3.3%
620	Osteochondrosis	3.3%
621	Spinal Diseases	3.3%
622	Synovitis	3.3%
623	Joint laxity	3.3%
624	Polyarthritis	3.3%
625	Frozen shoulder	3.3%
626	Patellofemoral Pain Syndrome	3.3%
627	Gigantism	3.3%
628	Spinal Neoplasms	3.3%
629	Spondylitis	3.3%
630	Reflex, Abnormal	3.3%
631	Hyporeflexia	3.3%
632	Hyperreflexia	3.3%
633	Neuroaspergillosis	3.3%
634	Osteoarthritis, Knee	3.3%
635	Akathisia	3.3%
636	Restlessness	3.3%
637	Psychomotor Agitation	3.3%
638	Prolactinoma	3.3%
639	Growth Hormone-Secreting Pituitary Adenoma	3.3%
640	Polyradiculopathy	3.3%
641	Multiple Sclerosis, Chronic Progressive	3.2%
642	Multiple Sclerosis, Relapsing-Remitting	3.2%
643	Nelson Syndrome	3.2%
644	Optic Nerve Glioma	3.2%
645	Arthritis, Psoriatic	3.2%
646	Pseudorabies	3%
647	Rubinstein-Taybi Syndrome	3%
648	Congenital clubfoot	3%
649	Vertical Talus	3%
650	Prader-Willi Syndrome	3%
651	Bone Diseases, Endocrine	2.9%
652	Gait Apraxia	2.9%
653	POEMS Syndrome	2.9%
654	Microcephaly	2.9%
655	Macrocephaly	2.9%
656	Neurosyphilis	2.9%
657	Bone Diseases, Infectious	2.9%
658	Bone neoplasms	2.9%
659	Maxillary Diseases	2.9%
660	Craniofacial Dysostosis	2.9%
661	Rheumatoid Nodule	2.9%
662	Bone Resorption	2.8%
663	Hemarthrosis	2.8%
664	Optic Atrophy	2.8%
665	Optic Neuritis	2.8%
666	Papilledema	2.8%
667	Strabismus	2.8%
668	Tietze's Syndrome	2.8%
669	Tolosa-Hunt Syndrome	2.8%
670	Limb Deformities, Congenital	2.8%
671	Arsenic Poisoning	2.8%
672	Craniofacial Abnormalities	2.8%
673	Aseptic Necrosis of Bone	2.8%
674	Facial Injuries	2.8%
675	Facial Neuralgia	2.8%
676	Sleep Talking	2.8%
677	Manganese Poisoning	2.8%
678	Sleep Disorders, Intrinsic	2.8%
679	Orthostatic intolerance	2.8%
680	Anosmia	2.8%
681	Ataxia	2.8%
682	Athetosis	2.8%
683	Catalepsy	2.8%
684	Dystonia	2.8%
685	Hemiplegia	2.8%
686	Locked-In Syndrome	2.8%
687	Meningeal Neoplasms	2.8%
688	Meningomyelocele	2.8%
689	Muscle Hypertonia	2.8%
690	Muscle hypotonia	2.8%
691	Myoclonus	2.8%
692	Myotonia	2.8%
693	Paraplegia	2.8%
694	Pseudobulbar Palsy	2.8%
695	Quadriplegia	2.8%
696	Spasm	2.8%
697	Spastic Paraplegia	2.8%
698	Status Epilepticus	2.8%
699	Taste Disorders	2.8%
700	Tremor	2.8%
701	Spina Bifida	2.8%
702	Monoplegia	2.8%
703	Hypokinesia	2.8%
704	Paraparesis	2.8%
705	Bradykinesia	2.8%
706	Waxy flexibility	2.8%
707	Action Tremor	2.8%
708	Resting Tremor	2.8%
709	Dysosmia	2.8%
710	Quadriparesis	2.8%
711	Mercury Poisoning, Nervous System	2.8%
712	Olfaction Disorders	2.8%
713	Myokymia	2.8%
714	Lead Poisoning, Nervous System	2.8%
715	Vestibular Neuronitis	2.8%
716	Somatosensory Disorders	2.8%
717	Hyperkinesia	2.8%
718	Intention tremor	2.8%
719	Arthritis, Reactive	2.8%
720	Acoustic Neuroma	2.8%
721	Anterior Spinal Artery Syndrome	2.8%
722	Brain Diseases	2.8%
723	Holoprosencephaly	2.7%
724	Kwashiorkor	2.7%
725	Magnesium Deficiency	2.7%
726	Potassium Deficiency	2.7%
727	Protein Deficiency	2.7%
728	Avitaminosis	2.7%
729	Jaw Abnormalities	2.7%
730	Poland Syndrome	2.7%
731	Prognathism	2.6%
732	Lyme Neuroborreliosis	2.6%
733	Neurofibrosarcoma	2.6%
734	Spondylarthropathies	2.6%
735	Felty Syndrome	2.5%
736	Waterhouse-Friderichsen Syndrome	2.5%
737	Vision Disorders	2.5%
738	Metamorphopsia	2.5%
739	Visual Impairment	2.5%
740	Obesity	2.5%
741	Porencephaly	2.5%
742	Optic Neuropathy, Ischemic	2.5%
743	Anterior Ischemic Optic Neuropathy	2.5%
744	Facial Hemiatrophy	2.5%
745	Melkersson-Rosenthal Syndrome	2.5%
746	Anisocoria	2.5%
747	Confusion	2.5%
748	Facial paralysis	2.5%
749	Lethargy	2.5%
750	Memory Disorders	2.5%
751	Perceptual Disorders	2.5%
752	Psychomotor Disorders	2.5%
753	Tonic Pupil	2.5%
754	Anhedonia	2.5%
755	Disorientation	2.5%
756	Gastroschisis	2.5%
757	Facial Paresis	2.5%
758	Memory Loss	2.5%
759	Hemisensory Neglect	2.5%
760	Dysacusis	2.5%
761	Sleep Bruxism	2.5%
762	Toxoplasmosis, Congenital	2.5%
763	Anencephaly	2.5%
764	Meningocele	2.5%
765	Muscular Atrophy	2.5%
766	Respiratory Paralysis	2.5%
767	Encephalocele	2.5%
768	Malaria, Cerebral	2.5%
769	Discitis	2.4%
770	Myopathy	2.4%
771	Neurocysticercosis	2.4%
772	Congenital Hypothyroidism	2.3%
773	Rheumatoid Vasculitis	2.3%
774	Classical Lissencephalies and Subcortical Band Heterotopias	2.3%
775	Duane Retraction Syndrome	2.2%
776	Nail-Patella Syndrome	2.2%
777	Consciousness Disorders	2.2%
778	Giant Cell Epulis	2.2%
779	Mental Retardation	2.2%
780	Depressed Level of Consciousness	2.2%
781	Mental deficiency	2.2%
782	Intellectual Disability	2.2%
783	Mobius Syndrome	2.2%
784	Bell Palsy	2.2%
785	Catatonia	2.2%
786	Herpes Zoster Oticus	2.2%
787	Aphonia	2.2%
788	Arthralgia	2.2%
789	Sleep Deprivation	2.2%
790	Polyarthralgia	2.2%
791	Dysphonia	2.2%
792	Ainhum	2.2%
793	Bunion	2.2%
794	Dysostoses	2.2%
795	Spinal Stenosis	2.2%
796	Spondylosis	2.2%
797	Intervertebral Disc Degeneration	2.2%
798	Sacroiliitis	2.2%
799	Postural Orthostatic Tachycardia Syndrome	2.2%
800	Ascorbic Acid Deficiency	2.2%
801	Vitamin A Deficiency	2.2%
802	Vitamin D Deficiency	2.2%
803	Vitamin E Deficiency	2.2%
804	Marasmus	2.2%
805	Tuberculosis, Spinal	2.2%
806	Sicca Syndrome	2.1%
807	Sjogren's Syndrome	2.1%
808	Laryngomalacia	2%
809	Obesity, Abdominal	2%
810	Mandibulofacial Dysostosis	2%
811	Eosinophilic Granuloma	2%
812	Alexia	1.9%
813	Dyslexia	1.9%
814	Palatal Neoplasms	1.9%
815	Micrognathism	1.9%
816	Pierre Robin Syndrome	1.9%
817	Goldenhar Syndrome	1.9%
818	Arthritis, Infectious	1.9%
819	Multiple Epiphyseal Dysplasia	1.9%
820	Osteochondrodysplasias	1.9%
821	Folic Acid Deficiency	1.9%
822	Pellagra	1.9%
823	Thiamine Deficiency	1.9%
824	Vitamin B 12 Deficiency	1.9%
825	Vitamin B 6 Deficiency	1.9%
826	Pyridoxine Deficiency	1.9%
827	Osteomyelitis	1.9%
828	Periostitis	1.9%
829	Arthritis, Experimental	1.9%
830	Alveolar Bone Loss	1.9%
831	Amelia	1.9%
832	Arachnodactyly	1.9%
833	Ectromelia	1.9%
834	Esotropia	1.9%
835	Exotropia	1.9%
836	Femur Head Necrosis	1.9%
837	Hemimelia	1.9%
838	Hypotension, Orthostatic	1.9%
839	Phocomelia	1.9%
840	Sirenomelia	1.9%
841	Sleep Apnea Syndromes	1.9%
842	Polydactyly	1.9%
843	Brachydactyly	1.9%
844	Plagiocephaly	1.9%
845	Lower Extremity Deformities, Congenital	1.9%
846	Upper Extremity Deformities, Congenital	1.9%
847	Post-Exercise Hypotension	1.9%
848	Osteolysis	1.9%
849	Disorders of Excessive Somnolence	1.9%
850	Sleep Initiation and Maintenance Disorders	1.9%
851	Night Terrors	1.9%
852	Somnambulism	1.9%
853	Trigeminal Nerve Disorder	1.9%
854	Transient Insomnia	1.9%
855	Sleep Paralysis	1.9%
856	Chronic Insomnia	1.9%
857	REM Sleep Behavior Disorder	1.9%
858	Hypersomnia	1.9%
859	Dermal Sinus	1.9%
860	Dysgeusia	1.9%
861	Formication	1.9%
862	Hyperalgesia	1.9%
863	Hyperesthesia	1.9%
864	Hypesthesia	1.9%
865	Language Disorders	1.9%
866	Numbness	1.9%
867	Paresthesia	1.9%
868	Paraparesis, Spastic	1.9%
869	Spina Bifida Cystica	1.9%
870	Trismus	1.9%
871	Spina Bifida Occulta	1.9%
872	Epilepsia Partialis Continua	1.9%
873	Hypogeusia	1.9%
874	Meningeal Carcinomatosis	1.9%
875	Brown-Sequard Syndrome	1.9%
876	Lissencephaly	1.9%
877	Polymicrogyria	1.9%
878	Pachygyria	1.9%
879	Schizencephaly	1.9%
880	Lockjaw	1.9%
881	Allodynia	1.9%
882	Lead Poisoning, Nervous System, Childhood	1.9%
883	Lead Poisoning, Nervous System, Adult	1.9%
884	Periventricular Nodular Heterotopia	1.9%
885	Ageusia	1.9%
886	Aicardi's syndrome	1.8%
887	Hoarseness	1.8%
888	Pediatric Obesity	1.8%
889	Alcohol Withdrawal Delirium	1.8%
890	Retrognathia	1.8%
891	Beriberi	1.8%
892	Dwarfism	1.7%
893	Eye Injuries	1.7%
894	Hip Dislocation	1.7%
895	Shoulder Dislocation	1.7%
896	Hip Dysplasia	1.7%
897	Congenital nystagmus	1.7%
898	Diplopia	1.6%
899	Scotoma	1.6%
900	Photophobia	1.6%
901	Hemifacial Spasm	1.6%
902	Amaurosis	1.6%
903	Blindness	1.6%
904	Basal Cell Nevus Syndrome	1.6%
905	Vitamin K Deficiency	1.6%
906	Joint Tuberculosis	1.6%
907	Tuberculosis, Osteoarticular	1.6%
908	Bone Tuberculosis	1.6%
909	Chondrodysplasia Punctata	1.6%
910	Enchondromatosis	1.6%
911	Lordosis	1.6%
912	Osteosclerosis	1.6%
913	Spondylolysis	1.6%
914	kyphosis	1.6%
915	Kashin-Beck Disease	1.6%
916	Agnosia	1.6%
917	Apraxias	1.6%
918	Hallucinations	1.6%
919	Hemianopsia	1.6%
920	Hyperacusis	1.6%
921	Tinnitus	1.6%
922	Visual Agnosia	1.6%
923	Anosognosia	1.6%
924	Wernicke-Korsakoff Syndrome	1.6%
925	Phonophobia	1.6%
926	Hearing Loss	1.6%
927	Sarcopenia	1.6%
928	Cleft Palate	1.5%
929	Anemia, Pernicious	1.5%
930	Maxillofacial Abnormalities	1.5%
931	Amnesia	1.5%
932	Delirium	1.5%
933	Dissociative Amnesia	1.5%
934	Color blindness	1.5%
935	Global Amnesia	1.5%
936	Cri-du-Chat Syndrome	1.5%
937	Down Syndrome	1.5%
938	Trisomy 21	1.5%
939	Bronchomalacia	1.5%
940	Tracheomalacia	1.5%
941	Meningioma	1.5%
942	Williams Syndrome	1.5%
943	Shoulder Pain	1.4%
944	Scurvy	1.4%
945	Sleep Apnea, Obstructive	1.4%
946	Sleep Apnea, Central	1.4%
947	Narcolepsy	1.4%
948	Trigeminal Neuralgia	1.4%
949	Kleine-Levin Syndrome	1.4%
950	Agraphia	1.4%
951	Anomia	1.4%
952	Cluttering	1.4%
953	Language Development Disorders	1.4%
954	Speech Disorders	1.4%
955	Syncope	1.4%
956	Stupor	1.4%
957	Dysgraphia	1.4%
958	Presyncope	1.4%
959	Dyslalia	1.4%
960	Melorheostosis	1.4%
961	Osteopetrosis	1.4%
962	Spondylolisthesis	1.4%
963	Phantom pain	1.3%
964	Phantom Limb Pain	1.3%
965	Osteogenesis Imperfecta	1.2%
966	Eye Burns	1.2%
967	Mastoiditis	1.2%
968	Petrositis	1.2%
969	Amaurosis Fugax	1.2%
970	Blindness, Cortical	1.2%
971	Dyscalculia	1.2%
972	Rett Syndrome	1.2%
973	Deafness	1.2%
974	Hearing Loss, Sudden	1.2%
975	Gerstmann Syndrome	1.2%
976	Hearing Loss, Bilateral	1.2%
977	Hearing Loss, High-Frequency	1.2%
978	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
979	Prosopagnosia	1.2%
980	Apraxia, Ideomotor	1.2%
981	Charles Bonnet Syndrome	1.2%
982	Hearing Loss, Unilateral	1.2%
983	Complete Hearing Loss	1.2%
984	Alien Hand Syndrome	1.2%
985	Deaf Mutism	1.2%
986	Noonan Syndrome	1.2%
987	Cataplexy	1.2%
988	Aphasia	1.2%
989	Articulation Disorders	1.2%
990	Echolalia	1.2%
991	Stuttering	1.2%
992	Dysphasia	1.2%
993	Marfan Syndrome	1.1%
994	Corneal Scar	1.1%
995	Retrograde amnesia	1.1%
996	Amnesia, Anterograde	1.1%
997	Dysarthria	1%
998	Mutism	1%
999	Selective Mutism	1%
1000	Fragile X Syndrome	1%
1001	Alexia, Pure	0.9%
1002	Corneal Perforation	0.9%
1003	Nose Neoplasms	0.8%
1004	Radicular Cyst	0.8%

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