MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Adiposis Dolorosa

(UMLS:C0001529)

Definition:: A rare disease characterized by multiple tumor-like fatty deposits that press on nerves in various sites causing pain and weakness. Often these lipoma-like structures are located on the trunk and limbs but not on the face and hands.
UMLS ID:: C0001529
MeSH ID:: D000274

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.463.249

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.718.500

Synonym(s)

Adiposis Dolorosa

ADIPOSIS DOLOROSA

Adiposis dolorosa

DERCUM DISEASE

DERCUM'S DISEASE

Dercum

Dercum Disease

Dercum's Disease

Dercum's disease

10.

Lipomatosis dolorosa

11.

Neurolipomatosis

12.

adiposis dolorosa

13.

adiposis dolorosa (Dercum's disease)

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Carbamazepine	FAERS: 1		US FAERS
2	Cyclosporine	FAERS: 1		US FAERS
3	Omeprazole	FAERS: 1		US FAERS
4	diclofenac hydroxyethylpyrrolidine	FAERS: 1		US FAERS
5	Cimetidine			OFFSIDES
6	Lidoderm		2430406	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lipodystrophy	27.8%
2	Pyoderma Gangrenosum	23.8%
3	Xanthomatosis	23.1%
4	Dyslipidemias	23.1%
5	Xanthoma	23.1%
6	Lupus Erythematosus, Cutaneous	20.5%
7	Panniculitis	20.5%
8	Systemic Scleroderma	20.5%
9	Morphea	20.5%
10	Breast Diseases	20.2%
11	Dermatitis	20.2%
12	Exanthema	20.2%
13	Facial Dermatoses	20.2%
14	Hair Diseases	20.2%
15	Hand Dermatoses	20.2%
16	keratoacanthoma	20.2%
17	Keratosis	20.2%
18	Nail Diseases	20.2%
19	Photosensitivity Disorders	20.2%
20	Prurigo	20.2%
21	Pyoderma	20.2%
22	Rosacea	20.2%
23	Sebaceous Gland Diseases	20.2%
24	Skin Diseases, Vesiculobullous	20.2%
25	Skin Ulcer	20.2%
26	Sweat Gland Diseases	20.2%
27	Skin Diseases, Papulosquamous	20.2%
28	Skin Diseases, Vascular	20.2%
29	Acneiform Eruptions	20.2%
30	Ocular Rosacea	20.2%
31	Subcorneal pustular dermatosis	20.2%
32	Erythematotelangiectatic Rosacea	20.2%
33	Papulopustular Rosacea	20.2%
34	Chronic Actinic Dermatitis	20.2%
35	Acne Vulgaris	19.8%
36	Contact Dermatitis	19.8%
37	Eczema	19.8%
38	Erythema Multiforme	19.8%
39	Intertrigo	19.8%
40	Neurodermatitis	19.8%
41	Rhinophyma	19.8%
42	Perioral Dermatitis	19.8%
43	Acne	19.8%
44	Necrobiosis Lipoidica Diabeticorum	19.8%
45	Xeroderma Pigmentosum	19.1%
46	Dermatitis, Phototoxic	17.5%
47	Pityriasis Lichenoides et Varioliformis Acuta	17.5%
48	Pityriasis Lichenoides	17.5%
49	Phototoxicity	17.5%
50	Foot Ulcer	17.2%
51	Wasting Syndrome	17.1%
52	Dermatitis, Atopic	17.1%
53	Epidermolysis Bullosa	17.1%
54	Acid-Base Imbalance	16.9%
55	Calcium Metabolism Disorders	16.9%
56	Iron Metabolism Disorders	16.9%
57	Phosphorus Metabolism Disorders	16.9%
58	Water-Electrolyte Imbalance	16.9%
59	Mitochondrial Diseases	16.9%
60	Glucose Metabolism Disorders	16.9%
61	Dermatitis Herpetiformis	16.1%
62	Foot Diseases	15.9%
63	Acrodermatitis	15.9%
64	Sebaceous Gland Neoplasms	15.9%
65	Porokeratosis	15.9%
66	Gianotti-Crosti Syndrome	15.9%
67	Keratoderma, Palmoplantar	15.9%
68	Skin Abnormalities	15.4%
69	Skin Diseases, Infectious	15.4%
70	Skin Neoplasms	15.4%
71	Pigmentation Disorders	15.4%
72	Panniculitis, Lupus Erythematosus	15.3%
73	Pruritus	15.1%
74	Erythema	15.1%
75	Necrolytic Migratory Erythema	15.1%
76	Cutaneous Fistula	15.1%
77	Nephrogenic Fibrosing Dermopathy	15.1%
78	Nephrogenic Systemic Fibrosis	15.1%
79	Hypercalcemia	14.9%
80	Hypocalcemia	14.9%
81	Milk-Alkali Syndrome	14.9%
82	Dermatitis, Irritant	14.6%
83	Acne Conglobata	14.6%
84	Dermatitis, Photoallergic	14.6%
85	Sjogren-Larsson Syndrome	14.3%
86	Urticaria Pigmentosa	13.7%
87	Xeroderma	13.4%
88	Dermatomyositis	13.4%
89	Lupus Erythematosus, Discoid	13.2%
90	Scleroderma, Limited	13.2%
91	Anhidrosis	13.2%
92	Cholesteatoma	13.2%
93	Pressure Ulcer	13.2%
94	Folliculitis	13.2%
95	Foot Dermatoses	13.2%
96	Gynecomastia	13.2%
97	Hypertrichosis	13.2%
98	Hypohidrosis	13.2%
99	Hypotrichosis	13.2%
100	Leg Ulcer	13.2%
101	Miliaria	13.2%
102	Parakeratosis	13.2%
103	Parapsoriasis	13.2%
104	Pityriasis	13.2%
105	Psoriasis	13.2%
106	Sweet Syndrome	13.2%
107	Hidradenitis	13.2%
108	Onycholysis	13.2%
109	Miliaria Rubra	13.2%
110	Hyperpigmentation	13.2%
111	Lichenoid Eruptions	13.2%
112	Chloracne	13.2%
113	Hypolipoproteinemias	13%
114	Erythema Induratum	12.8%
115	Osteopenia	12.8%
116	Brain Diseases, Metabolic	12.6%
117	Hyperlipoproteinemia Type IV	12.6%
118	Hyperlipoproteinemia Type V	12.6%
119	Dermatitis, Occupational	12.2%
120	Diaper Rash	12.1%
121	Cutis Laxa	12.1%
122	Mastocytosis	12%
123	Connective Tissue Diseases	11.8%
124	Dermatitis, Allergic Contact	11.8%
125	HIV-Associated Lipodystrophy Syndrome	11.8%
126	Porphyrias, Hepatic	11.7%
127	Papillon-Lefevre Disease	11.7%
128	Erythema Infectiosum	11.7%
129	Exanthema Subitum	11.6%
130	Erythema Nodosum	11.4%
131	Ectodermal Dysplasia	11.4%
132	Aplasia Cutis Congenita	11.4%
133	Hypercholesterolemia	11.4%
134	Hyperlipoproteinemias	11.4%
135	Hypertriglyceridemia	11.4%
136	Pseudohypoparathyroidism	11.3%
137	Pseudoxanthoma Elasticum	11.1%
138	Toxic Epidermal Necrolysis	11%
139	Stevens-Johnson Syndrome	11%
140	Ichthyosis, X-Linked	10.7%
141	Hyperlipidemia, Familial Combined	10.7%
142	Nutrition Disorders	10.6%
143	Smith-Lemli-Opitz Syndrome	10.6%
144	Tinea Capitis	10.5%
145	Onychomycosis	10.5%
146	Rickets	10.5%
147	Acantholysis	10.1%
148	Breast Cyst	10.1%
149	Actinic keratosis	10.1%
150	Pemphigoid, Benign Mucous Membrane	10.1%
151	Pemphigus	10.1%
152	Piedra	10.1%
153	Sunburn	10.1%
154	Albinism	9.9%
155	Argyria	9.9%
156	Hirsutism	9.9%
157	Lactation Disorder	9.9%
158	Mastitis	9.9%
159	Urticaria	9.9%
160	Acidosis	9.9%
161	Alkalosis	9.9%
162	Amyloidosis	9.9%
163	Calcinosis	9.9%
164	Hyperglycemia	9.9%
165	Hyperinsulinism	9.9%
166	Hyperkalemia	9.9%
167	Hypernatremia	9.9%
168	Hypoglycemia	9.9%
169	Hypokalemia	9.9%
170	Hyponatremia	9.9%
171	Hypophosphatemia	9.9%
172	Metabolic acidosis	9.9%
173	Iron Overload	9.9%
174	Brain Diseases, Metabolic, Inborn	9.9%
175	Granuloma Annulare	9.9%
176	Pruritus Vulvae	9.8%
177	Ecthyma	9.8%
178	Mastocytoma	9.8%
179	Pruritus Ani	9.8%
180	Lichen Planus	9.8%
181	Melanosis	9.8%
182	Chloasma	9.8%
183	Pityriasis Rosea	9.8%
184	Pityriasis Rubra Pilaris	9.8%
185	Vitiligo	9.8%
186	Lichen Nitidus	9.8%
187	Hyperkeratosis, Epidermolytic	9.7%
188	Hypoalphalipoproteinemias	9.6%
189	Hyperlipoproteinemia Type III	9.5%
190	Leigh Disease	9.2%
191	Hyperhomocysteinemia	8.8%
192	Behcet Syndrome	8.7%
193	Neuronal Ceroid-Lipofuscinoses	8.6%
194	Hidradenitis Suppurativa	8.4%
195	Lactose Intolerance	8.2%
196	Variegate Porphyria	8.2%
197	Acute intermittent porphyria	8.2%
198	Porphyria Cutanea Tarda	8.2%
199	Homocystinuria	8.1%
200	Acanthosis Nigricans	8.1%
201	Alopecia Areata	8.1%
202	Lentigo	8.1%
203	Menkes Kinky Hair Syndrome	8.1%
204	Dermatomycoses	8.1%
205	Mucocutaneous Lymph Node Syndrome	8.1%
206	Skin Diseases, Bacterial	8.1%
207	Carbamoyl-Phosphate Synthase I Deficiency Disease	8%
208	Drug Eruptions	7.9%
209	Livedo Reticularis	7.9%
210	Malignant Atrophic Papulosis	7.9%
211	Polyarteritis Nodosa	7.8%
212	Takayasu Arteritis	7.8%
213	Diabetes Mellitus	7.8%
214	Tinea Pedis	7.6%
215	Erythema Chronicum Migrans	7.6%
216	Dehydration	7.6%
217	Water Intoxication	7.6%
218	Werner Syndrome	7.6%
219	Alopecia	7.5%
220	Sweating, Gustatory	7.5%
221	Androgenetic Alopecia	7.5%
222	Auriculotemporal Syndrome	7.5%
223	Achlorhydria	7.4%
224	Amino Acid Metabolism, Inborn Errors	7.4%
225	Bloom Syndrome	7.4%
226	Carbohydrate Metabolism, Inborn Errors	7.4%
227	Metal Metabolism, Inborn Errors	7.4%
228	Osteoporosis	7.4%
229	Progeria	7.4%
230	Lysosomal Storage Diseases	7.4%
231	Bone Demineralization, Pathologic	7.4%
232	Cytochrome-c Oxidase Deficiency	7.4%
233	Peroxisomal Disorders	7.4%
234	Post-Traumatic Osteoporosis	7.4%
235	Celiac Disease	7.4%
236	Lice Infestations	7.4%
237	Sprue, Tropical	7.4%
238	Steatorrhea	7.4%
239	Varicose Ulcer	7.4%
240	Sprue	7.4%
241	Breast Neoplasms, Male	7.4%
242	Triple Negative Breast Neoplasms	7.4%
243	Gaucher Disease	7.4%
244	Galactorrhea	7.3%
245	CREST Syndrome	7.3%
246	Galactosemias	7.3%
247	Urea Cycle Disorders, Inborn	7.3%
248	Tyrosinemias	7.3%
249	Osteomalacia	7.1%
250	Mitochondrial Encephalomyopathies	7%
251	Diabetic Ketoacidosis	6.8%
252	Nail-Patella Syndrome	6.8%
253	Collagen Diseases	6.7%
254	Mixed Connective Tissue Disease	6.7%
255	Mucinoses	6.7%
256	Congenital Hyperinsulinism	6.7%
257	Acidosis, Lactic	6.5%
258	Calciphylaxis	6.5%
259	Hemosiderosis	6.5%
260	Ketosis	6.5%
261	Ketonuria	6.5%
262	Ketoacidosis	6.5%
263	Ketonemia	6.5%
264	Vascular calcification	6.5%
265	Mycetoma	6.5%
266	Hyperphosphaturia	6.5%
267	Familial Hypophosphatemic Rickets	6.4%
268	Lichen Planus, Oral	6.2%
269	Mitochondrial Myopathies	6%
270	Larva Migrans	6%
271	Leishmaniasis	6%
272	Molluscum Contagiosum	6%
273	Myelinolysis, Central Pontine	6%
274	Angioedema	6%
275	Onchocerciasis	5.9%
276	Glycosuria	5.9%
277	Reye Syndrome	5.9%
278	Tay-Sachs Disease	5.9%
279	Chromoblastomycosis	5.9%
280	Dermatophytosis	5.9%
281	Hepatic Encephalopathy	5.9%
282	Sporotrichosis	5.9%
283	Tinea	5.9%
284	Tinea Versicolor	5.9%
285	Trichophytosis	5.9%
286	Hyalohyphomycosis	5.9%
287	Niemann-Pick Disease, Type C	5.9%
288	Acute Generalized Exanthematous Pustulosis	5.8%
289	Fabry Disease	5.8%
290	Glycogen storage disease type II	5.7%
291	HIV Wasting Syndrome	5.6%
292	Child Nutrition Disorders	5.6%
293	Hypervitaminosis A	5.6%
294	Infant Nutrition Disorders	5.6%
295	Malnutrition	5.6%
296	Renal tubular acidosis	5.5%
297	Mucopolysaccharidosis III	5.5%
298	Amyloid Neuropathies, Familial	5.4%
299	Cartilage Diseases	5.3%
300	Rheumatism	5.3%
301	Chondromalacia	5.3%
302	Lupus Erythematosus, Systemic	5.1%
303	Overlap syndrome	5.1%
304	Warts	5.1%
305	Acidosis, Respiratory	4.9%
306	Alkalosis, Respiratory	4.9%
307	Candidiasis, Chronic Mucocutaneous	4.9%
308	Cutaneous Candidiasis	4.9%
309	Zellweger Syndrome	4.9%
310	Erysipelas	4.9%
311	Fanconi Anemia	4.9%
312	Nesidioblastosis	4.9%
313	Serum Sickness	4.9%
314	Staphylococcal Skin Infections	4.9%
315	Leishmaniasis, Cutaneous	4.9%
316	Eczema Herpeticum	4.9%
317	Alkaptonuria	4.9%
318	Erythrasma	4.9%
319	Glycogen Storage Disease	4.9%
320	Hypophosphatasia	4.9%
321	Insulin Resistance	4.9%
322	Osteoporosis, Postmenopausal	4.9%
323	Carcinoma, Lobular	4.9%
324	Propionic acidemia	4.9%
325	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
326	Cystinosis	4.9%
327	Arthritis, Psoriatic	4.9%
328	Fusariosis	4.8%
329	Adrenoleukodystrophy	4.8%
330	MELAS Syndrome	4.8%
331	Wernicke Encephalopathy	4.7%
332	Renal Osteodystrophy	4.7%
333	Renal rickets	4.7%
334	Hepatolenticular Degeneration	4.5%
335	Refsum Disease	4.5%
336	Scleromyxedema	4.4%
337	Hereditary Angioedema Type III	4.3%
338	Hereditary Angioedema Types I and II	4.3%
339	Giant Cell Arteritis	4.3%
340	Temporal Arteritis	4.3%
341	Glycosuria, Renal	4.3%
342	Friedreich Ataxia	4.2%
343	Angioedemas, Hereditary	4.1%
344	Epidermodysplasia Verruciformis	4.1%
345	Herpes Labialis	4.1%
346	Diabetic Foot	4.1%
347	Gestational Diabetes	4.1%
348	Latent Autoimmune Diabetes in Adults	4.1%
349	Staphylococcal Scalded Skin Syndrome	4%
350	Diabetes Mellitus, Experimental	4%
351	Dupuytren Contracture	4%
352	Nephrocalcinosis	3.9%
353	Tetany	3.9%
354	Cerebral Amyloid Angiopathy	3.9%
355	Mucopolysaccharidosis II	3.9%
356	Kernicterus	3.7%
357	Cockayne Syndrome	3.7%
358	Peutz-Jeghers Syndrome	3.7%
359	Blastomycosis	3.7%
360	Glycogen Storage Disease Type I	3.6%
361	Glycogen Storage Disease Type V	3.6%
362	Kearns-Sayre syndrome	3.6%
363	carbuncle	3.6%
364	Condylomata Acuminata	3.5%
365	Furunculosis	3.5%
366	furuncle	3.5%
367	Impetigo	3.4%
368	Mesenteric Panniculitis	3.4%
369	Panniculitis, Peritoneal	3.4%
370	Tietze's Syndrome	3.4%
371	Orbital Cellulitis	3.4%
372	Myxoid cyst	3.4%
373	Ataxia Telangiectasia	3.4%
374	Rhinoscleroma	3.4%
375	Cellulitis	3.3%
376	Familial Periodic Paralysis	3.3%
377	Myxedema	3.3%
378	Deficiency Diseases	3.3%
379	Starvation	3.3%
380	Primary amyloidosis	3.3%
381	Refeeding Syndrome	3.3%
382	Optic Atrophy, Hereditary, Leber	3.3%
383	Renal Aminoacidurias	3.2%
384	Fanconi Syndrome	3.2%
385	Pseudohypoaldosteronism	3.2%
386	Liddle Syndrome	3.2%
387	Canavan Disease	2.9%
388	Alexander Disease	2.9%
389	Gout	2.8%
390	Amyotrophic Lateral Sclerosis	2.8%
391	Antley-Bixler Syndrome Phenotype	2.8%
392	Osteochondritis	2.7%
393	Polymyalgia Rheumatica	2.7%
394	Osteogenesis Imperfecta	2.7%
395	Keloid	2.6%
396	Noonan Syndrome	2.5%
397	Hypokalemic periodic paralysis	2.4%
398	Frontotemporal dementia	2.4%
399	Cystinuria	2.4%
400	Rheumatoid Arthritis	2.3%
401	Juvenile arthritis	2.3%
402	Marfan Syndrome	2.2%
403	Kwashiorkor	2.2%
404	Magnesium Deficiency	2.2%
405	Potassium Deficiency	2.2%
406	Protein Deficiency	2.2%
407	Avitaminosis	2.2%
408	Lupus Nephritis	2.2%
409	Arthritis, Gouty	2.1%
410	Rheumatoid Nodule	2%
411	Laryngomalacia	2%
412	Pectus carinatum	1.9%
413	Felty Syndrome	1.6%
414	Bronchomalacia	1.6%
415	Tracheomalacia	1.6%
416	Ascorbic Acid Deficiency	1.6%
417	Vitamin A Deficiency	1.6%
418	Vitamin D Deficiency	1.6%
419	Vitamin E Deficiency	1.6%
420	Marasmus	1.6%
421	Obesity	1.6%
422	Rheumatoid Vasculitis	1.4%
423	Folic Acid Deficiency	1.3%
424	Pellagra	1.3%
425	Thiamine Deficiency	1.3%
426	Vitamin B 12 Deficiency	1.3%
427	Vitamin B 6 Deficiency	1.3%
428	Pyridoxine Deficiency	1.3%
429	Obesity, Abdominal	1.3%
430	Sicca Syndrome	1.2%
431	Sjogren's Syndrome	1.2%
432	Beriberi	1.2%
433	Pediatric Obesity	1.1%
434	Lupus Vasculitis, Central Nervous System	1%
435	Vitamin K Deficiency	1%
436	Prader-Willi Syndrome	0.9%
437	Anemia, Pernicious	0.9%
438	Scurvy	0.8%
439	Subacute Combined Degeneration	0.5%

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