MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperemia

(UMLS:C0020452)

Definition:: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
UMLS ID:: C0020452
MeSH ID:: D006940

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.474

Synonym(s)

Hyperemia

Engorgement

Engorgement, NOS

HYPEREMIA

Hyperaemia

Hyperaemia, NOS

Hyperemia, NOS

Local congestion

Vascular engorgement

10.

engorgement

11.

hyperaemia

12.

hyperemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	6-(2-propargyloxyphenyl)hexanoic acid	12459681	CTD
2	8-phenyltheophylline	7641332	CTD
3	Acetaminophen	11917207	CTD
4	Acetazolamide	15296063	CTD
5	Acetylcysteine	5305168	CTD
6	Adenosine Triphosphate	View details 3813054 9840701 12381087 12794626	CTD
7	Adenosine	View details 2841874 7586405 16330034 19496111	CTD
8	Alcohols	15314997 29339218	CTD
9	Amlodipine	11973410	CTD
10	Amodiaquine	2663213	CTD
11	Aspirin	2504081 3966642 9431267	CTD
12	Atenolol	15326083	CTD
13	Atropine	12468513 15009014	CTD
14	Azithromycin	19108788	CTD
15	Bepridil	3871297	CTD
16	Betamethasone	16156157	CTD
17	Bimatoprost	View details 11434939 11448321 12365906 15321024 16644608	CTD
18	Brimonidine Tartrate	10877374	CTD
19	Caffeine	19496111	CTD
20	Capsaicin	View details 1514632 7507874 7885033 8048007 8290056 8601381 8845006 8846404 9806218 11837250 15009014 18205911	CTD
21	Carbamazepine	28267586	CTD
22	Carmustine	6421125	CTD
23	Carvedilol	12062733	CTD
24	Cyclophosphamide	6896169 9792975	CTD
25	D-JNKI-1	22427801	CTD
26	Dexamethasone	1514632 11004044	CTD
27	Diazinon	29383019 30359674	CTD
28	Dihydroergotoxine	618778	CTD
29	Dipyridamole	View details 1555293 1564236 2110037 2348231 2681325 2761383 3177197 6978059 7249300 7600651 7796497 8017281 8025998 8221859 8254386 8273756 8622587 8921787 8962555 9074535 9205015 9426021 9544659 9669263 9679717 10073812 10190876 10636254 10758630 11173779 11222474 11241807 11342469 11479248 11641194 11666096 11815423 12062733 12900738 15326083 15452468 15778950 16330034 17541306 17659557 18552138 19488826 19496111	CTD
30	Dobutamine	9337211 12468513	CTD
31	Doxorubicin	31100273	CTD
32	Epinephrine	1138682 2502780 5646032	CTD
33	Ergotamine	8197748	CTD
34	Felodipine	8369003	CTD
35	Gentamicins	2275936	CTD
36	Glyburide	7768272	CTD
37	Halothane	8214724 11004044 16256270	CTD
38	Hexamethonium	15009014	CTD
39	Hydrochloric Acid	View details 8601381 9806218 10564113 11837250 12646421	CTD
40	Hydrogen Peroxide	10792963	CTD
41	Iloprost	2435669	CTD
42	Indomethacin	10792963 12524144 18688582	CTD
43	Isoflurane	8214724 12459681 15815331	CTD
44	Isoproterenol	3101516 8845006	CTD
45	Lansoprazole	29339218	CTD
46	Latanoprost	View details 7819171 8628544 8694726 17102001 17416939	CTD
47	Lincomycin	1127264	CTD
48	Linezolid	19763761	CTD
49	Lithium Carbonate	19393521	CTD
50	Mepivacaine	9690594	CTD
51	Methotrexate	30025850	CTD
52	Methylene Blue	7949234	CTD
53	Metoprolol	9074535 12900738	CTD
54	Morphine	4058695	CTD
55	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	11004044	CTD
56	Naloxone	4058695	CTD
57	Nicotine	15500638	CTD
58	Nifedipine	3778419	CTD
59	Nitric Oxide	View details 1505282 7934020 11156591 12459681	CTD
60	Nitroglycerin	View details 7586405 12860835 17345787 17929130	CTD
61	Nitrous Oxide	8214724	CTD
62	Norepinephrine	View details 1138682 1581859 7949234 9277469	CTD
63	Papaverine	View details 2358592 3881002 6240483 8287414 8601879 8892781 9840701 11249884 17351955 18568317	CTD
64	Pentagastrin	7824855	CTD
65	Phenylephrine	7828311	CTD
66	Pilocarpine	7698938 9090610	CTD
67	Propofol	8085629 9632972	CTD
68	Propranolol	7949234	CTD
69	Pyrilamine	1514632	CTD
70	Simvastatin	17521631	CTD
71	Sodium Chloride	10564113	CTD
72	Sulfasalazine	22427801 25727887	CTD
73	Sumatriptan	8290056	CTD
74	Taurocholic Acid	7934020	CTD
75	Tetrodotoxin	8637627	CTD
76	Theophylline	2348231 19496111	CTD
77	Timolol	8628544 8694726 17102001	CTD
78	Travoprost	15321024	CTD
79	Trinitrobenzenesulfonic Acid	View details 18288370 21070844 21808981 22147983 22427801 24038091 25727887	CTD
80	Yohimbine	2841874 7949234	CTD
81	beta-patchoulene	29339218	CTD
82	bis(tri-n-butyltin)oxide	11884216	CTD
83	bisphenol A	29558425	CTD
84	calcitonin gene-related peptide (8-37)	8048007	CTD
85	capsazepine	9806218	CTD
86	dorzolamide-timolol combination	17416939	CTD
87	doxantrazole	1514632	CTD
88	icatibant	11837250	CTD
89	imidapril	11973410	CTD
90	leonurine	31005592	CTD
91	morin	31100273	CTD
92	perhexiline maleate	215079	CTD
93	pimagedine	11004044	CTD
94	proanthocyanidin	18205911	CTD
95	tetrabromobisphenol A	25846749	CTD
96	zatebradine	8426013	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Aneurysm	42.9%
2	Angiomatosis	42.9%
3	Aortic Diseases	42.9%
4	Arterial Occlusive Diseases	42.9%
5	Hypotension	42.9%
6	Superior Vena Cava Syndrome	42.9%
7	Telangiectasis	42.9%
8	Vasculitis	42.9%
9	Venous Insufficiency	42.9%
10	Peripheral Vascular Diseases	42.9%
11	Embolism and Thrombosis	42.9%
12	Angiodysplasia	42.9%
13	Capillary Leak Syndrome	42.9%
14	Prehypertension	42.9%
15	Aortic Aneurysm	40.9%
16	Aortitis	40.9%
17	Leriche Syndrome	40.9%
18	Periphlebitis	40.9%
19	Phlebitis	40.9%
20	Thromboangiitis Obliterans	40.9%
21	Myocardial Ischemia	38.1%
22	Postphlebitic Syndrome	37.1%
23	Thrombophlebitis	35.8%
24	Blue Toe Syndrome	34.3%
25	Aortic Aneurysm, Abdominal	33.3%
26	Aortic Aneurysm, Thoracic	33.3%
27	Retinal Vein Occlusion	32.5%
28	Coronary Aneurysm	31.7%
29	Aneurysm, Dissecting	31%
30	Arteriosclerosis	31%
31	Arteritis	31%
32	Embolism	31%
33	Erythromelalgia	31%
34	Fibromuscular Dysplasia	31%
35	Malignant Hypertension	31%
36	Raynaud Disease	31%
37	Thromboembolism	31%
38	Thrombosis	31%
39	Essential Hypertension	31%
40	Aneurysm, Ruptured	31%
41	Iliac Aneurysm	31%
42	Pulmonary artery stenosis	31%
43	White Coat Hypertension	31%
44	Systemic Vasculitis	31%
45	Embolus	31%
46	Malignant Atrophic Papulosis	30.5%
47	Shwartzman Phenomenon	30.3%
48	Aortic Rupture	30.2%
49	Vascular System Injuries	30%
50	Coronary Thrombosis	28.9%
51	Coronary Artery Disease	28.9%
52	Compartment syndromes	28.6%
53	Hepatic Veno-Occlusive Disease	28.6%
54	Peliosis Hepatis	28.6%
55	Varicocele	28.6%
56	Carotid Artery Thrombosis	28.4%
57	Cerebrovascular Disorders	27.9%
58	Diabetic Angiopathies	27.9%
59	Reperfusion Injury	27.9%
60	Splenic Infarction	27.9%
61	Cerebrovascular Insufficiency	27.9%
62	Vascular Neoplasms	27.9%
63	Spinal Cord Vascular Diseases	27.9%
64	Vasoplegia	27.9%
65	Hemorrhoids	27.6%
66	Thoracic Outlet Syndrome	27.6%
67	Intracranial Embolism and Thrombosis	27.5%
68	Carotid Stenosis	27.4%
69	Intracranial Aneurysm	27.4%
70	Coronary heart disease	27.3%
71	Myocardial Infarction	27.3%
72	Acute Coronary Syndrome	27.3%
73	Myocardial Reperfusion Injury	26.8%
74	Arteriosclerosis Obliterans	25.4%
75	Atherosclerosis	25.4%
76	Air Embolism	25.4%
77	Endarteritis	25.4%
78	Venous Thrombosis	25.4%
79	Deep Vein Thrombosis	25.4%
80	Venous Thromboembolism	25.4%
81	Moyamoya Disease	25.3%
82	Polyarteritis Nodosa	25%
83	Takayasu Arteritis	25%
84	Intracranial Arteriosclerosis	24.7%
85	Cerebral Atherosclerosis	24.7%
86	Cerebral Arteriosclerosis	24.7%
87	Cerebral Thrombosis	23.4%
88	Intracranial Embolism	23.4%
89	Intracranial Thrombosis	23.4%
90	Heart Diseases	23.1%
91	Coronary Occlusion	22.2%
92	Microvascular Angina	22.2%
93	Coronary Stenosis	22.2%
94	ST segment elevation myocardial infarction	22.2%
95	Hand-Arm Vibration Syndrome	21.8%
96	Arteriovenous fistula	21.6%
97	Sinus Thrombosis, Intracranial	21.3%
98	Optic Neuropathy, Ischemic	21.1%
99	Anterior Ischemic Optic Neuropathy	21.1%
100	Mesenteric vascular insufficiency	21.1%
101	Retinal Artery Occlusion	20.9%
102	Retinal Vasculitis	20.9%
103	Hypertensive Retinopathy	20.9%
104	Kounis Syndrome	20.7%
105	Anterior Compartment Syndrome	20.5%
106	Vasculitis, Leukocytoclastic, Cutaneous	20.5%
107	Gastric Antral Vascular Ectasia	20.5%
108	Abdominal Compartment Syndrome	20.5%
109	Cavernous Sinus Thrombosis	20.3%
110	Sagittal Sinus Thrombosis	20.3%
111	Angioedema	20.3%
112	Vasculitis, Central Nervous System	20.3%
113	Colitis, Ischemic	20.3%
114	Carotid Artery Diseases	20.2%
115	Brain Ischemia	20.2%
116	Hypotension, Orthostatic	20.2%
117	Cerebrovascular accident	20.2%
118	Varicose Ulcer	20.2%
119	Vasospasm, Intracranial	20.2%
120	Spinal Cord Ischemia	20.2%
121	Intracranial Arterial Diseases	20.2%
122	Primary Graft Dysfunction	20.2%
123	Post-Exercise Hypotension	20.2%
124	May-Thurner Syndrome	20.2%
125	Angina Pectoris	20.1%
126	Coronary Restenosis	19.8%
127	Embolism, Amniotic Fluid	19.7%
128	Brain Infarction	19.6%
129	Lemierre Syndrome	18.9%
130	Giant Cell Arteritis	18.5%
131	Temporal Arteritis	18.5%
132	Infarction, Middle Cerebral Artery	17.8%
133	Infarction, Anterior Cerebral Artery	17.8%
134	Infarction, Posterior Cerebral Artery	17.8%
135	Cerebral Infarction	17.5%
136	Brain Stem Infarctions	17.5%
137	Intermittent Claudication	17.2%
138	Pulmonary Embolism	17.2%
139	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	17.2%
140	Subarachnoid Hemorrhage, Traumatic	17%
141	Carotid Artery, Internal, Dissection	17%
142	No-Reflow Phenomenon	16.9%
143	Shock, Cardiogenic	16.7%
144	Cerebral Arterial Diseases	16.6%
145	Vertebrobasilar Insufficiency	16.6%
146	Anterior Spinal Artery Syndrome	16.6%
147	Basilar Artery Stenosis	16.6%
148	Vertebral Artery Stenosis	16.6%
149	Intracranial Hemorrhage, Hypertensive	16.6%
150	Transient Cerebral Ischemia	16.6%
151	Vertebral Artery Dissection	16.5%
152	Angina, Unstable	16.4%
153	Lateral Medullary Syndrome	16.4%
154	Mesenteric Vascular Occlusion	15.5%
155	Mucocutaneous Lymph Node Syndrome	15.5%
156	CREST Syndrome	15.5%
157	Hepatic Vein Thrombosis	15.4%
158	Budd-Chiari Syndrome	15.4%
159	Diabetic Retinopathy	15.4%
160	Sturge-Weber Syndrome	15.4%
161	Livedo Reticularis	15.3%
162	Renal hypertension	15.1%
163	Renal Artery Obstruction	15.1%
164	Renal Artery Stenosis	15.1%
165	Pulmonary Infarction	15.1%
166	Hemangioma, Cavernous	15%
167	Pregnancy Complications, Cardiovascular	15%
168	Cardiovascular Abnormalities	15%
169	Basal Ganglia Cerebrovascular Disease	15%
170	Vascular Headaches	14.9%
171	Scurvy	14.9%
172	Subclavian Steal Syndrome	14.8%
173	Scimitar Syndrome	14.8%
174	Angina Pectoris, Variant	14.6%
175	Cardiac Tamponade	14.3%
176	Endocarditis	14.3%
177	Cardiac Arrest	14.3%
178	Heart failure	14.3%
179	Pericardial effusion	14.3%
180	Pericarditis	14.3%
181	Pneumopericardium	14.3%
182	Cor pulmonale	14.3%
183	Ventricular Outflow Obstruction	14.3%
184	Ventricular Dysfunction	14.3%
185	Cardiomyopathies	14.3%
186	Pleuropericarditis	14.3%
187	Carotid Artery Injuries	14.1%
188	Aortic Valve Stenosis	13.6%
189	Cardiomyopathy, Dilated	13.6%
190	Pulmonary Valve Stenosis	13.6%
191	Basal Ganglia Hemorrhage	13.1%
192	Hypertension, Renovascular	12.3%
193	Subarachnoid Hemorrhage	12.3%
194	Hypoxia-Ischemia, Brain	12.3%
195	Cerebral Hemorrhage	12.3%
196	Hereditary Angioedema Type III	12.2%
197	Hereditary Angioedema Types I and II	12.2%
198	Ischemic contracture	12.2%
199	Angioedemas, Hereditary	12.1%
200	Tricuspid Atresia	12.1%
201	Arrhythmogenic Right Ventricular Dysplasia	12.1%
202	Putaminal Hemorrhage	12%
203	Cryoglobulinemia	12%
204	Leukomalacia, Periventricular	12%
205	Diabetic Foot	11.9%
206	Hypertrophic Cardiomyopathy	11.7%
207	Hypertrophic obstructive cardiomyopathy	11.7%
208	Granulomatosis with polyangiitis	11.3%
209	Supravalvular aortic stenosis	11.1%
210	Lown-Ganong-Levine Syndrome	11.1%
211	Cerebral Amyloid Angiopathy	11%
212	Dementia, Vascular	11%
213	Aortic Valve Insufficiency	10.3%
214	Restrictive cardiomyopathy	10.3%
215	Endocardial Fibroelastosis	10.3%
216	Heart Rupture, Post-Infarction	10.3%
217	Mitral Valve Insufficiency	10.3%
218	Mitral Valve Stenosis	10.3%
219	Myocarditis	10.3%
220	Pericarditis, Constrictive	10.3%
221	Pulmonary Valve Insufficiency	10.3%
222	Tricuspid Valve Insufficiency	10.3%
223	Tricuspid Valve Stenosis	10.3%
224	Ventricular Dysfunction, Left	10.3%
225	Right Ventricular Dysfunction	10.3%
226	Endomyocardial Fibrosis	10.3%
227	Carditis	10.3%
228	Heart Failure, Systolic	10.3%
229	Heart Failure, Diastolic	10.3%
230	Heart Block	10.2%
231	Tachycardia	10.2%
232	Tachyarrhythmia	10.2%
233	Aortic coarctation	10.1%
234	Cor Triatriatum	10.1%
235	Coronary Vessel Anomalies	10.1%
236	Patent ductus arteriosus	10.1%
237	Ebstein Anomaly	10.1%
238	Heart Septal Defects	10.1%
239	Tetralogy of Fallot	10.1%
240	Transposition of Great Vessels	10.1%
241	Hypoplastic Left Heart Syndrome	10.1%
242	Pituitary Apoplexy	10%
243	Shy-Drager Syndrome	9.9%
244	Purpura, Hyperglobulinemic	9.9%
245	Bacterial Endocarditis	9.7%
246	Cardiac Output, High	9.5%
247	Myocardial Stunning	9.5%
248	Low Cardiac Output Syndrome	9.5%
249	Cardiomegaly	9.3%
250	Postpericardiotomy Syndrome	9.3%
251	Cardiac Hypertrophy	9.3%
252	Rheumatic Heart Disease	9.1%
253	Behcet Syndrome	8.6%
254	Waldenstrom Macroglobulinemia	8.6%
255	Multiple Myeloma	8.6%
256	Aortic Valve Prolapse	8.5%
257	Tricuspid Valve Prolapse	8.5%
258	Takotsubo Cardiomyopathy	8.5%
259	Rheumatoid Vasculitis	8.3%
260	Adams-Stokes Syndrome	8.3%
261	Atrioventricular Block	8.3%
262	Bundle-Branch Block	8.3%
263	Atrial Premature Complexes	8.3%
264	Sinoatrial Block	8.3%
265	Tachycardia, Paroxysmal	8.3%
266	Supraventricular tachycardia	8.3%
267	Tachycardia, Ventricular	8.3%
268	Wolff-Parkinson-White Syndrome	8.3%
269	Tachycardia, Reciprocating	8.3%
270	Aortopulmonary Septal Defect	8.2%
271	Double Outlet Right Ventricle	8.2%
272	Endocardial Cushion Defects	8.2%
273	Myocardial bridging	8.2%
274	Aorticopulmonary Septal Defect	8.2%
275	Sick Sinus Syndrome	8.2%
276	Lupus Vasculitis, Central Nervous System	8.2%
277	Dextrocardia	8.1%
278	Long QT Syndrome	8.1%
279	Ataxia Telangiectasia	7.6%
280	Pseudoxanthoma Elasticum	7.6%
281	Tachycardia, Atrioventricular Nodal Reentry	7.3%
282	Tachycardia, Ectopic Atrial	7.3%
283	Tachycardia, Ectopic Junctional	7.3%
284	Sinus Tachycardia	7.3%
285	Torsades de Pointes	7.3%
286	Accelerated Idioventricular Rhythm	7.3%
287	Truncus Arteriosus, Persistent	7.3%
288	Sinus Arrhythmia	6.8%
289	Atrial Fibrillation	6.8%
290	Atrial Flutter	6.8%
291	Edema, Cardiac	6.8%
292	Ventricular Fibrillation	6.8%
293	Ventricular Flutter	6.8%
294	Parasystole	6.8%
295	Paroxysmal atrial fibrillation	6.8%
296	Bradycardia	6.8%
297	Diabetic Cardiomyopathies	6.8%
298	Cardiomyopathy, Alcoholic	6.7%
299	Ectopia Cordis	6.7%
300	Sudden Cardiac Death	6.7%
301	Left Ventricular Hypertrophy	6.7%
302	Right Ventricular Hypertrophy	6.7%
303	Single umbilical artery	6.7%
304	Chagas Cardiomyopathy	6.7%
305	Romano-Ward Syndrome	6.6%
306	Hematoma, Subdural	6.3%
307	Hematoma, Epidural, Cranial	6.3%
308	Subacute Bacterial Endocarditis	6.1%
309	Hematoma, Subdural, Intracranial	5.9%
310	Hematoma, Subdural, Chronic	5.9%
311	Hematoma, Subdural, Acute	5.9%
312	Noonan Syndrome	5.8%
313	Sinus Arrest, Cardiac	5.6%
314	Brain Hemorrhage, Traumatic	5.5%
315	Carcinoid Heart Disease	5.3%
316	Marfan Syndrome	5.1%
317	Dyspnea, Paroxysmal	5%
318	MELAS Syndrome	4.9%
319	Dural Arteriovenous Fistula	4.1%
320	Fabry Disease	3.7%
321	Williams Syndrome	3%
322	Turner Syndrome	2.8%
323	Kartagener Syndrome	2.6%
324	Kearns-Sayre syndrome	1.8%

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