MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rheumatic Fever

(UMLS:C0035436)

Definition:: A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.
UMLS ID:: C0035436
MeSH ID:: D012213

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.890.731

Classification 2:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.550.114.843|C05.799.825

Synonym(s)

Rheumatic Fever

ARF

ARF - Acute rheumatic fever

Active rheumatic fever

Acute Rheumatic Fever

Acute articular rheumatism

Acute rheumatic arthritis

Acute rheumatic attack

Acute rheumatic fever

10.

RHEUMATIC ARTHRITIS ACUTE

11.

RHEUMATIC FEVER

12.

RHEUMATIC FEVER ACUTE

13.

RHEUMATISM, INFLAMMATORY

14.

RhF - Rheumatic fever

15.

Rheumatic fever

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 8		US FAERS
2	Alendronate	FAERS: 6		US FAERS
3	Lenalidomide	FAERS: 5		OFFSIDES US FAERS
4	rofecoxib	FAERS: 4		OFFSIDES US FAERS
5	Azithromycin	FAERS: 3		US FAERS
6	Atorvastatin	FAERS: 2		US FAERS
7	Moxifloxacin	FAERS: 2		US FAERS
8	Vemurafenib	FAERS: 2		US FAERS
9	ambrisentan	FAERS: 2		US FAERS
10	apremilast	FAERS: 2		US FAERS
11	pimecrolimus	FAERS: 2		OFFSIDES US FAERS
12	tofacitinib	FAERS: 2		US FAERS
13	Anastrozole	FAERS: 1		US FAERS
14	Celecoxib	FAERS: 1		US FAERS
15	Dimethyl Fumarate	FAERS: 1		US FAERS
16	Fingolimod Hydrochloride	FAERS: 1		US FAERS
17	Fluoxetine	FAERS: 1		US FAERS
18	Lisdexamfetamine Dimesylate	FAERS: 1		US FAERS
19	Methylphenidate	FAERS: 1		US FAERS
20	Norgestrel	FAERS: 1		US FAERS
21	Rivaroxaban	FAERS: 1		US FAERS
22	Thyroxine	FAERS: 1		US FAERS
23	Zoledronic Acid	FAERS: 1		US FAERS
24	palbociclib	FAERS: 1		US FAERS
25	Aspirin		3752019 11886462	CTD
26	Bisacodyl			OFFSIDES
27	Chlorthalidone			OFFSIDES
28	Ciprofloxacin			OFFSIDES
29	Estradiol			OFFSIDES
30	Glatiramer Acetate			OFFSIDES
31	Ketotifen			OFFSIDES
32	Methotrexate		16639489	CTD
33	Prednisone		3944744	CTD
34	Promethazine			OFFSIDES
35	Quinidine			OFFSIDES
36	Tretinoin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Osteoarthritis, Spine	38.1%
2	Periarthritis	34.9%
3	Gout	34.3%
4	Osteoarthritis, Knee	32%
5	Rheumatoid Arthritis	31.2%
6	Juvenile arthritis	31.2%
7	Arthritis, Psoriatic	29.3%
8	Sacroiliitis	28.6%
9	Contracture	27.6%
10	Osteoarthropathy, Secondary Hypertrophic	27.6%
11	Arthritis, Reactive	27%
12	Arthrogryposis	26.6%
13	Arthritis, Infectious	26.5%
14	Rheumatoid Nodule	26.5%
15	Ankylosing spondylitis	25.5%
16	Arthritis, Gouty	25.4%
17	Fibromyalgia	25.1%
18	Polymyalgia Rheumatica	25.1%
19	Pneumococcal Infections	25%
20	Scarlet Fever	25%
21	Arthritis, Experimental	22.8%
22	Felty Syndrome	22.7%
23	Metatarsalgia	22.7%
24	Bursitis	22.2%
25	Joint Instability	22.2%
26	Synovitis	22.2%
27	Joint laxity	22.2%
28	Frozen shoulder	22.2%
29	Patellofemoral Pain Syndrome	22.2%
30	Spondylarthropathies	21.8%
31	Rheumatoid Vasculitis	19.8%
32	Impetigo	19.6%
33	Bone Diseases	19.5%
34	Fasciitis	19.5%
35	Foot Deformities	19.5%
36	Erysipelas	19.3%
37	Fasciitis, Plantar	19.3%
38	Temporomandibular Joint Disorders	18.9%
39	Hip Contracture	18.8%
40	Ischemic contracture	18.2%
41	Hemarthrosis	17.7%
42	Actinomycetales Infections	17.6%
43	Clostridium Infections	17.6%
44	Listeriosis	17.6%
45	Staphylococcal Infections	17.6%
46	Bacillaceae Infections	17.6%
47	Sicca Syndrome	17.6%
48	Clostridium difficile infection	17.6%
49	Sjogren's Syndrome	17.6%
50	Ecthyma	16.9%
51	Subacute Bacterial Endocarditis	16.9%
52	Pectus carinatum	16.2%
53	Jaw Diseases	16.1%
54	Osteochondritis	16%
55	Temporomandibular Joint Dysfunction Syndrome	15.9%
56	Cartilage Diseases	15.6%
57	Foot Diseases	15.6%
58	Myopathy	15.6%
59	Chondromalacia	15.6%
60	Erysipelothrix infection	14.7%
61	Platybasia	14.3%
62	Pectus excavatum	13.6%
63	Meningitis, Pneumococcal	13.3%
64	Bone Diseases, Infectious	13.1%
65	Spondylitis	12.8%
66	Gram-Negative Bacterial Infections	12.8%
67	Talipes	12.7%
68	Nail-Patella Syndrome	12.7%
69	Arthralgia	12.4%
70	Polyarthralgia	12.4%
71	Klippel-Feil Syndrome	12.4%
72	Synostosis	12.4%
73	Tuberculosis, Spinal	12.1%
74	Borrelia Infections	12.1%
75	Leptospirosis	12.1%
76	Joint Tuberculosis	12%
77	Tuberculosis, Osteoarticular	12%
78	Bone Tuberculosis	12%
79	Bone Diseases, Developmental	12%
80	Hyperostosis	12%
81	Myofascial Pain Syndromes	12%
82	Osteitis	12%
83	Osteitis Deformans	12%
84	Osteochondrosis	12%
85	Rhabdomyolysis	12%
86	Spinal Diseases	12%
87	Staphylococcal Skin Infections	11.8%
88	Actinomycosis	11.7%
89	Corynebacterium Infections	11.7%
90	Gas Gangrene	11.7%
91	Mycobacterium Infections	11.7%
92	Nocardia Infections	11.7%
93	Tetanus	11.7%
94	Pulmonary Nocardiosis	11.7%
95	Central Nervous System Bacterial Infections	11.4%
96	Acrocephalosyndactylia	11.2%
97	Gigantism	11.2%
98	Spinal Neoplasms	11.2%
99	Craniosynostosis	11.1%
100	Syndactyly	11.1%
101	Brachycephaly	11.1%
102	Arthropathy	10.6%
103	Congenital clubfoot	10.5%
104	Vertical Talus	10.5%
105	Hip Dislocation	10.3%
106	Shoulder Dislocation	10.3%
107	Hip Dysplasia	10.3%
108	Skin Diseases, Bacterial	10.2%
109	Erythrasma	10.1%
110	Bacterial Vaginosis	10.1%
111	Bacteremia	10.1%
112	Craniofacial Dysostosis	9.9%
113	Bone Diseases, Endocrine	9.9%
114	Discitis	9.9%
115	Lyme Disease	9.9%
116	Relapsing Fever	9.9%
117	Bone neoplasms	9.7%
118	Compartment syndromes	9.7%
119	Maxillary Diseases	9.7%
120	Osteopenia	9.7%
121	Tendinitis	9.7%
122	Tendinopathy	9.7%
123	Bone Resorption	9.5%
124	Myositis	9.5%
125	Tietze's Syndrome	9.5%
126	Limb Deformities, Congenital	9.5%
127	Isaacs syndrome	9.5%
128	Craniofacial Abnormalities	9.5%
129	Aseptic Necrosis of Bone	9.5%
130	Myotonic Disorders	9.5%
131	Meningitis, Listeria	9.4%
132	Lyme Neuroborreliosis	9.2%
133	Poland Syndrome	9.2%
134	Bacterial Endocarditis	8.8%
135	Osteomyelitis	8.7%
136	Periostitis	8.7%
137	Diphtheria	8.7%
138	Leprosy	8.7%
139	Mycobacterium Infections, Nontuberculous	8.7%
140	Tuberculosis	8.7%
141	Mycobacterium abscessus Infection	8.7%
142	Mycetoma	8.7%
143	Pneumonia, Bacterial	8.5%
144	Neurosyphilis	8.5%
145	Shoulder Pain	8.4%
146	Ainhum	8.4%
147	Bunion	8.4%
148	Dysostoses	8.4%
149	Fibrodysplasia Ossificans Progressiva	8.4%
150	Myoglobinuria	8.4%
151	Myositis Ossificans	8.4%
152	Spinal Stenosis	8.4%
153	Spondylosis	8.4%
154	Tenosynovitis	8.4%
155	Intervertebral Disc Degeneration	8.4%
156	Staphylococcal Scalded Skin Syndrome	8.4%
157	Syphilis	8.4%
158	Jaw Abnormalities	8.2%
159	Prognathism	8.1%
160	Erythema Chronicum Migrans	8%
161	Medial Tibial Stress Syndrome	8%
162	Mycoses	8%
163	Infection	8%
164	Human Ehrlichiosis	7.9%
165	Mitochondrial Myopathies	7.9%
166	Muscle Cramp	7.9%
167	Eosinophilia-Myalgia Syndrome	7.9%
168	Gastroschisis	7.9%
169	Muscle Rigidity	7.8%
170	Muscle Spasticity	7.8%
171	Cogwheel Rigidity	7.8%
172	Nuchal Rigidity	7.8%
173	Enterocolitis, Pseudomembranous	7.7%
174	pseudomembranous colitis	7.7%
175	Bordetella Infections	7.6%
176	Brucellosis	7.6%
177	Campylobacter infection	7.6%
178	Congenital Hypothyroidism	7.6%
179	Enterobacteriaceae Infections	7.6%
180	Pseudomonas Infections	7.6%
181	Q Fever	7.6%
182	Vibrio Infections	7.6%
183	Helicobacter Infections	7.6%
184	Neisseriaceae Infections	7.6%
185	Burkholderia Infections	7.6%
186	Flavobacteriaceae Infections	7.6%
187	Moraxellaceae Infections	7.6%
188	Burkholderia cepacia Infection	7.6%
189	Furunculosis	7.4%
190	furuncle	7.4%
191	Goldenhar Syndrome	7.3%
192	Mycobacterium avium-intracellulare Infection	7.2%
193	Lymph Node Tuberculosis	7.2%
194	Tuberculosis, Miliary	7.2%
195	Tuberculosis, Multidrug-Resistant	7.2%
196	Leprosy, Multibacillary	7.2%
197	Latent Tuberculosis	7.2%
198	Pyomyositis	7.2%
199	Rheumatism	7.1%
200	Mandibulofacial Dysostosis	7%
201	Chronic Fatigue Syndrome	7%
202	Chlamydia Infections	7%
203	Gonorrhea	7%
204	Antley-Bixler Syndrome Phenotype	7%
205	Japanese Spotted Fever	6.9%
206	Human anaplasmosis	6.9%
207	Arthritis	6.8%
208	Polyarthritis	6.8%
209	Multiple Epiphyseal Dysplasia	6.8%
210	Osteochondrodysplasias	6.8%
211	Giant Cell Epulis	6.8%
212	Muscle Weakness	6.8%
213	Rheumatic Fever	6.7%
214	Botulism	6.7%
215	Musculoskeletal Pain	6.7%
216	carbuncle	6.7%
217	Anterior Compartment Syndrome	6.7%
218	Osteoporosis	6.7%
219	Enthesopathy	6.7%
220	Bone Demineralization, Pathologic	6.7%
221	Post-Traumatic Osteoporosis	6.7%
222	Abdominal Compartment Syndrome	6.7%
223	Familial Periodic Paralysis	6.7%
224	Alveolar Bone Loss	6.7%
225	Amelia	6.7%
226	Arachnodactyly	6.7%
227	Chondrodysplasia Punctata	6.7%
228	Ectromelia	6.7%
229	Enchondromatosis	6.7%
230	Femur Head Necrosis	6.7%
231	Hemimelia	6.7%
232	Lordosis	6.7%
233	Osteosclerosis	6.7%
234	Phocomelia	6.7%
235	Sirenomelia	6.7%
236	Spondylolysis	6.7%
237	Polymyositis	6.7%
238	Polydactyly	6.7%
239	Brachydactyly	6.7%
240	Plagiocephaly	6.7%
241	Lower Extremity Deformities, Congenital	6.7%
242	Upper Extremity Deformities, Congenital	6.7%
243	kyphosis	6.7%
244	Kashin-Beck Disease	6.7%
245	Osteolysis	6.7%
246	Borderline leprosy	6.5%
247	Leprosy, Lepromatous	6.5%
248	Tuberculoid leprosy	6.5%
249	Extensively Drug-Resistant Tuberculosis	6.5%
250	Central Nervous System Infection	6.4%
251	Palatal Neoplasms	6.2%
252	Micrognathism	6.2%
253	Pierre Robin Syndrome	6.2%
254	Laryngomalacia	6%
255	Rubinstein-Taybi Syndrome	6%
256	Myotonic Dystrophy	6%
257	Tuberculosis, Gastrointestinal	5.9%
258	Dwarfism	5.8%
259	Eosinophilic Granuloma	5.8%
260	Myalgia	5.8%
261	Melorheostosis	5.8%
262	Osteopetrosis	5.8%
263	Spondylolisthesis	5.8%
264	Hidradenitis Suppurativa	5.8%
265	Tuberculosis, Central Nervous System	5.8%
266	Tuberculosis, Meningeal	5.6%
267	Muscular Dystrophy	5.6%
268	Orbital Myositis	5.6%
269	Dupuytren Contracture	5.6%
270	Retrognathia	5.6%
271	Acromegaly	5.5%
272	Mastoiditis	5.5%
273	Petrositis	5.5%
274	Rocky Mountain Spotted Fever	5.4%
275	Osteoporosis, Postmenopausal	5.3%
276	Hordeolum	5.3%
277	Ulcerative stomatitis	5.3%
278	Bacterial conjunctivitis	5.2%
279	Rhinoscleroma	5.2%
280	Pertussis	5.1%
281	Erythema Induratum	5%
282	Acinetobacter Infections	5%
283	Bacteroides Infections	5%
284	Cholera	5%
285	Escherichia coli Infections	5%
286	Haemophilus Infections	5%
287	Klebsiella Infections	5%
288	Meningococcal Infections	5%
289	Mycoplasma Infections	5%
290	Pasteurella Infections	5%
291	Proteus Infections	5%
292	Rickettsia Infections	5%
293	Salmonella infections	5%
294	Scrub Typhus	5%
295	Syphilis, Congenital	5%
296	Serratia Infections	5%
297	Ureaplasma Infections	5%
298	Meningitis, Bacterial	5%
299	Basal Cell Nevus Syndrome	5%
300	Tuberculosis, Pulmonary	5%
301	Meningitis, Haemophilus	4.9%
302	Lymphogranuloma Venereum	4.9%
303	Maxillofacial Abnormalities	4.8%
304	Myotonia Congenita	4.8%
305	Rickets	4.7%
306	Bronchomalacia	4.7%
307	Tracheomalacia	4.7%
308	Microcephaly	4.7%
309	Macrocephaly	4.7%
310	Hypokalemic periodic paralysis	4.7%
311	Cleft Palate	4.6%
312	Dermatomycoses	4.5%
313	Osteogenesis Imperfecta	4.5%
314	Welander Distal Myopathy	4.4%
315	Ophthalmia Neonatorum	4.4%
316	Trachoma	4.4%
317	Aspergillosis	4.3%
318	Candidiasis	4.3%
319	Coccidioidomycosis	4.3%
320	Histoplasmosis	4.3%
321	Paracoccidioidomycosis	4.3%
322	Pelvic Infection	4.3%
323	Wound Infection	4.3%
324	Zygomycosis	4.3%
325	Soft Tissue Infection	4.3%
326	Community-Acquired Infections	4.3%
327	Phaeohyphomycosis	4.3%
328	Pneumocystis Infections	4.3%
329	Pseudohypoparathyroidism	4.1%
330	Mitochondrial Encephalomyopathies	4.1%
331	Dermatomyositis	3.9%
332	Candidiasis, Chronic Mucocutaneous	3.8%
333	Cutaneous Candidiasis	3.8%
334	Muscular Dystrophy, Duchenne	3.8%
335	Osteomalacia	3.7%
336	Porencephaly	3.7%
337	Psittacosis	3.7%
338	Paratyphoid Fever	3.7%
339	Plague	3.7%
340	Typhoid Fever	3.7%
341	TYPHUS	3.7%
342	Yersinia pseudotuberculosis Infections	3.7%
343	Bubonic Plague	3.7%
344	Noonan Syndrome	3.7%
345	Panophthalmitis	3.6%
346	Eye Infection	3.5%
347	Respiratory Tract Infections	3.5%
348	Otomycosis	3.4%
349	Pregnancy Complications, Infectious	3.4%
350	Skin Diseases, Infectious	3.4%
351	Piedra	3.4%
352	Central Nervous System Fungal Infections	3.4%
353	Suppuration	3.4%
354	Cross Infection	3.4%
355	Marfan Syndrome	3.4%
356	Septicemia	3.4%
357	Sepsis	3.4%
358	Brain Abscess	3.4%
359	Neuroaspergillosis	3.3%
360	Fungemia	3.3%
361	Holoprosencephaly	3.3%
362	Dysentery, Bacillary	3.3%
363	Tuberculosis, Renal	3.3%
364	Candidemia	3.3%
365	Salmonella Infections, Animal	3.1%
366	Opportunistic Infections	3%
367	Salmonella food poisoning	3%
368	Cockayne Syndrome	3%
369	Blastomycosis	3%
370	Lung Diseases, Fungal	2.9%
371	Cellulitis	2.9%
372	Radicular Cyst	2.9%
373	Urinary tract infection	2.9%
374	Chromoblastomycosis	2.8%
375	Dermatophytosis	2.8%
376	Sporotrichosis	2.8%
377	Tinea	2.8%
378	Tinea Versicolor	2.8%
379	Trichophytosis	2.8%
380	Invasive Pulmonary Aspergillosis	2.8%
381	Hyalohyphomycosis	2.8%
382	Endotoxemia	2.8%
383	Nose Neoplasms	2.7%
384	Renal Osteodystrophy	2.6%
385	Renal rickets	2.6%
386	Mucormycosis	2.5%
387	Sexually Transmitted Diseases	2.5%
388	Meningitis, Cryptococcal	2.4%
389	Waterhouse-Friderichsen Syndrome	2.2%
390	MELAS Syndrome	2.2%
391	Oral candidiasis	2%
392	Endophthalmitis	2%
393	Peritonitis	2%
394	Surgical Wound Infection	2%
395	Pulmonary Aspergillosis	2%
396	Bronchopulmonary Aspergillosis	2%
397	Abscess	2%
398	Adnexitis	2%
399	Empyema	2%
400	Pelvic Inflammatory Disease	2%
401	Kearns-Sayre syndrome	2%
402	Fusariosis	1.9%
403	Superinfection	1.7%
404	Corneal Ulcer	1.7%
405	Puerperal Infection	1.7%
406	Appendicitis	1.7%
407	Bacteriuria	1.7%
408	Pyuria	1.7%
409	Psoas Abscess	1.7%
410	Meningitis, Fungal	1.7%
411	Abdominal Abscess	1.7%
412	Lemierre Syndrome	1.7%
413	Endotoxic shock	1.7%
414	Septic Shock	1.7%
415	Toxic Shock Syndrome	1.7%
416	Candidiasis, Vulvovaginal	1.6%
417	Tinea Capitis	1.6%
418	Onychomycosis	1.6%
419	Familial Hypophosphatemic Rickets	1.5%
420	Toxoplasmosis, Cerebral	1.5%
421	Tinea Pedis	1.4%
422	Diverticulitis	1.3%
423	AIDS-Related Opportunistic Infections	1.3%
424	Lung Abscess	1.1%
425	Diverticulum	1.1%
426	Diverticulosis	1.1%
427	Liver Abscess	1%
428	Retropharyngeal Abscess	1%
429	Epidural Abscess	0.9%
430	Peritonsillar Abscess	0.9%
431	Aspergillosis, Allergic Bronchopulmonary	0.8%
432	Liver Abscess, Amebic	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234