MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Antithrombin III Deficiency

(UMLS:C0272375)

Definition:: An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.
UMLS ID:: C0272375
MeSH ID:: D020152

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.100.075|C15.378.147.150|C15.378.925.075

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.099.075

Synonym(s)

Antithrombin III Deficiency

ANTITHROMBIN III DEFICIENCY

AT deficiency - Antithrombin deficiency

AT-III deficiency

Anti-thrombin III deficiency

Antithombin III deficiency

Antithrombin 3 deficiency

Antithrombin III deficiency

Antithrombin deficiency

10.

Decreased antithrombin III

11.

Reduced antithrombin III activity

12.

antithrombin 3 deficiency

13.

antithrombin III deficiency

14.

antithrombin deficiencies

15.

antithrombin deficiency

16.

antithrombin iii deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	NuvaRing	FAERS: 5		OFFSIDES US FAERS
2	norgestimate, ethinyl estradiol drug combination	FAERS: 2		US FAERS
3	reviparin	FAERS: 2	11446944	CTD US FAERS
4	Valproic Acid	FAERS: 1		US FAERS
5	apixaban	FAERS: 1		US FAERS
6	Aztreonam			OFFSIDES
7	Dexamethasone			OFFSIDES
8	Ganciclovir			OFFSIDES
9	Medroxyprogesterone Acetate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Protein C Deficiency	71.9%
2	Protein S Deficiency	67.8%
3	Activated Protein C Resistance	64.6%
4	Disseminated Intravascular Coagulation	60.2%
5	Thrombasthenia	58.7%
6	Afibrinogenemia	58%
7	Factor VII Deficiency	58%
8	Factor X Deficiency	58%
9	Factor XII Deficiency	58%
10	Hemophilia A	58%
11	Factor II deficiency	58%
12	Factor VIII Deficiency	58%
13	Factor V deficiency	58%
14	Factor XI Deficiency	58%
15	Hypoprothrombinemias	58%
16	Thrombocythemia, Essential	49.9%
17	Wiskott-Aldrich Syndrome	46.3%
18	Vitamin K Deficiency	36.7%
19	Anemia	34.2%
20	Blood Platelet Disorders	34.2%
21	Bone Marrow Diseases	34.2%
22	Hemorrhagic Disorders	34.2%
23	Leukocyte Disorders	34.2%
24	Methemoglobinemia	34.2%
25	Pancytopenia	34.2%
26	Polycythemia	34.2%
27	Sulfhemoglobinemia	34.2%
28	Erythrocytosis	34.2%
29	Purpura, Thrombotic Thrombocytopenic	33.1%
30	Hypoproteinemia	32.5%
31	Anemia, Sickle Cell	31.5%
32	Thalassemia	31.5%
33	Thrombocytosis	31.3%
34	Bone Marrow Neoplasms	31.3%
35	Anemia, Diamond-Blackfan	30.6%
36	Monoclonal Gammopathy of Undetermined Significance	29.6%
37	Transfusion Reaction	29.5%
38	Hypotensive Transfusion Reaction	29.5%
39	Polycythemia Vera	29.4%
40	Pregnancy Complications, Hematologic	28.8%
41	Hematologic Neoplasms	28.8%
42	Agammaglobulinemia	28.7%
43	Pelger-Huet Anomaly	28.5%
44	Paraproteinemias	27.4%
45	Hemoglobinuria, Paroxysmal	26.2%
46	Leukemoid Reaction	26.2%
47	Antithrombin III Deficiency	24.8%
48	Cryoglobulinemia	24.7%
49	Blood Coagulation Disorders	24.2%
50	Sickle Cell Trait	24.1%
51	Hypoalbuminemia	23.7%
52	Hypergammaglobulinemia	23.7%
53	Waldenstrom Macroglobulinemia	23.4%
54	Autoimmune thrombocytopenia	22.7%
55	Immune thrombocytopenic purpura	22.7%
56	Heavy Chain Disease	22.2%
57	Thrombophilia	22.1%
58	Anemia, Hemolytic	21.9%
59	Anemia, Macrocytic	21.9%
60	Eosinophilia	21.9%
61	Leukopenia	21.9%
62	Thrombocytopenia	21.9%
63	Leukostasis	21.9%
64	MYELODYSPLASTIC SYNDROME	21.9%
65	Anemia, Neonatal	21.8%
66	Ecchymosis	21.3%
67	Petechiae	21.3%
68	Purpura	21.3%
69	Fanconi Anemia	20.9%
70	Purpura, Hyperglobulinemic	20.4%
71	Lymphatic Diseases	20%
72	Multiple Myeloma	19.8%
73	Acute Chest Syndrome	19.6%
74	Hydrops Fetalis	19.2%
75	Thrombocytopenic purpura	19.1%
76	Leukocytosis	18.4%
77	Pleocytosis	18.4%
78	Infectious Mononucleosis	18.2%
79	Hemolytic-Uremic Syndrome	17.7%
80	Chronic granulomatous disease	17%
81	POEMS Syndrome	16.5%
82	Waterhouse-Friderichsen Syndrome	16.2%
83	Primary Myelofibrosis	15.8%
84	Agranulocytosis	15.8%
85	Anemia, Megaloblastic	15.8%
86	Lymphocytosis	15.8%
87	Myelofibrosis	15.8%
88	Myeloid Metaplasia	15.8%
89	Hypereosinophilic syndrome	15.8%
90	bone marrow fibrosis	15.8%
91	Thrombotic Microangiopathies	15.8%
92	Transfusion-Related Acute Lung Injury	15.7%
93	Purpura Fulminans	15%
94	Atypical Hemolytic Uremic Syndrome	14.8%
95	Lymphopenia	13.3%
96	Job Syndrome	13.2%
97	Leukemia, Myelomonocytic, Chronic	13.1%
98	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	13.1%
99	Lymphatic Abnormalities	13%
100	Neutropenia	12.8%
101	Kernicterus	12.3%
102	Lymphangiectasis, Intestinal	12.3%
103	Autoimmune Lymphoproliferative Syndrome	12.2%
104	Pseudoxanthoma Elasticum	12.1%
105	Eosinophilic Granuloma	11.8%
106	Eosinophilia-Myalgia Syndrome	11.4%
107	Adenitis	11.4%
108	Histiocytosis	11.4%
109	Lymphadenitis	11.4%
110	Lymphangitis	11.4%
111	Lymphedema	11.4%
112	Splenic Diseases	11.4%
113	Thymus Hyperplasia	11.4%
114	Pseudolymphoma	11.4%
115	Lymphadenopathy	11.4%
116	Shwartzman Phenomenon	11.3%
117	Febrile Neutropenia	11.3%
118	Hemangioma, Cavernous	11.3%
119	Scurvy	11.2%
120	Aicardi's syndrome	11.1%
121	Fragile X Syndrome	10.8%
122	Pulmonary Eosinophilia	10.8%
123	Eosinophilic Pneumonia	10.8%
124	Leukemia, Myeloid, Chronic-Phase	10.6%
125	Anemia, Pernicious	10.6%
126	CHARGE Syndrome	10.5%
127	Neoplastic Syndromes, Hereditary	10.4%
128	Cystic Fibrosis	10.3%
129	Ichthyosis, X-Linked	10.1%
130	Multiple Epiphyseal Dysplasia	10.1%
131	Osteochondrodysplasias	10.1%
132	Werner Syndrome	10.1%
133	Myasthenic Syndromes, Congenital	10.1%
134	Albinism	9.9%
135	Muscular Dystrophy, Duchenne	9.9%
136	Lymphocele	9.6%
137	Lymphoproliferative Disorders	9.6%
138	Thymus Neoplasms	9.5%
139	Beckwith-Wiedemann Syndrome	9.5%
140	Wolf-Hirschhorn Syndrome	9.5%
141	Nail-Patella Syndrome	9.3%
142	Cockayne Syndrome	9.3%
143	Alstrom Syndrome	9.1%
144	Mucopolysaccharidosis II	8.9%
145	Dwarfism	8.9%
146	Muscular Dystrophy	8.6%
147	Osteogenesis Imperfecta	8.6%
148	Rett Syndrome	8.4%
149	Smith-Magenis syndrome	8.4%
150	Menkes Kinky Hair Syndrome	8.4%
151	Cri-du-Chat Syndrome	8.3%
152	Down Syndrome	8.3%
153	Trisomy 21	8.3%
154	Mucocutaneous Lymph Node Syndrome	8.1%
155	Kartagener Syndrome	8.1%
156	Familial Mediterranean Fever	7.9%
157	Holoprosencephaly	7.8%
158	Marfan Syndrome	7.6%
159	Angioedemas, Hereditary	7.4%
160	Ectodermal Dysplasia	7.4%
161	Aplasia Cutis Congenita	7.4%
162	Prader-Willi Syndrome	7.3%
163	Elephantiasis	7.3%
164	Hypersplenism	7.3%
165	Sarcoidosis	7.3%
166	Elephantiasis Nostras Verrucosa	7.3%
167	Smith-Lemli-Opitz Syndrome	7.2%
168	Myotonic Dystrophy	7.2%
169	Neuronal Ceroid-Lipofuscinoses	7.1%
170	Adrenoleukodystrophy	7%
171	Deformity	6.9%
172	Rubinstein-Taybi Syndrome	6.9%
173	Tuberous Sclerosis	6.9%
174	Kallmann Syndrome	6.7%
175	Sjogren-Larsson Syndrome	6.7%
176	Amino Acid Metabolism, Inborn Errors	6.6%
177	Carbohydrate Metabolism, Inborn Errors	6.6%
178	Metal Metabolism, Inborn Errors	6.6%
179	Progeria	6.6%
180	Lysosomal Storage Diseases	6.6%
181	Cytochrome-c Oxidase Deficiency	6.6%
182	Peroxisomal Disorders	6.6%
183	Hepatolenticular Degeneration	6.6%
184	Polycystic Kidney Diseases	6.6%
185	Williams Syndrome	6.6%
186	Primary Ciliary Dyskinesia	6.5%
187	Refsum Disease	6.5%
188	Fabry Disease	6.5%
189	Amyloid Neuropathies, Familial	6.2%
190	Granuloma	6.1%
191	Histiocytic Disorders, Malignant	6.1%
192	Splenic Infarction	6.1%
193	Splenic Neoplasms	6.1%
194	Histiocytosis, Langerhans-Cell	6.1%
195	Tumor Lysis Syndrome	6.1%
196	Retinal Dysplasia	6%
197	Glycogen storage disease type II	6%
198	Aniridia	6%
199	Sezary Syndrome	5.9%
200	Epidermolysis Bullosa	5.9%
201	Galactosemias	5.9%
202	Urea Cycle Disorders, Inborn	5.9%
203	Tyrosinemias	5.9%
204	Niemann-Pick Disease, Type C	5.8%
205	Fetal Diseases	5.8%
206	Cutis Laxa	5.7%
207	Retinitis Pigmentosa	5.7%
208	Pigmentary retinopathy	5.7%
209	Porokeratosis	5.7%
210	Keratoderma, Palmoplantar	5.7%
211	Welander Distal Myopathy	5.6%
212	Ataxia Telangiectasia	5.5%
213	Mucopolysaccharidosis III	5.4%
214	Optic Atrophy, Hereditary, Leber	5.3%
215	Hyperphosphaturia	5.3%
216	Splenic Rupture	5.3%
217	Canavan Disease	5.3%
218	Alexander Disease	5.3%
219	Lymphohistiocytosis, Hemophagocytic	5.3%
220	Lymphoma	5.3%
221	Erdheim-Chester Disease	5.3%
222	Thymoma	5.2%
223	Zellweger Syndrome	5.2%
224	Duane Retraction Syndrome	5.1%
225	Porphyrias, Hepatic	5%
226	Gaucher Disease	5%
227	Peutz-Jeghers Syndrome	5%
228	Myotonia Congenita	5%
229	Brain Diseases, Metabolic, Inborn	5%
230	Classical Lissencephalies and Subcortical Band Heterotopias	5%
231	Dystonia Musculorum Deformans	4.9%
232	Alkaptonuria	4.9%
233	Glycogen Storage Disease	4.9%
234	Hypophosphatasia	4.9%
235	Propionic acidemia	4.9%
236	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
237	Cystinosis	4.9%
238	Homocystinuria	4.9%
239	Lafora Disease	4.9%
240	Unverricht-Lundborg Syndrome	4.9%
241	Leigh Disease	4.9%
242	Polycystic Kidney, Autosomal Dominant	4.9%
243	Hyperkeratosis, Epidermolytic	4.7%
244	Tay-Sachs Disease	4.5%
245	Meconium Aspiration Syndrome	4.5%
246	Multiple Endocrine Neoplasia	4.5%
247	Xeroderma Pigmentosum	4.5%
248	Congenital Hypothyroidism	4.4%
249	Dermatitis, Atopic	4.4%
250	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
251	Malignant histiocytosis	4.4%
252	Sarcoidosis, Pulmonary	4.4%
253	Histiocytic sarcoma	4.4%
254	Charcot-Marie-Tooth Disease	4.4%
255	Antley-Bixler Syndrome Phenotype	4.4%
256	Hypolipoproteinemias	4.2%
257	Papillon-Lefevre Disease	4.2%
258	Hyperlipidemia, Familial Combined	4.2%
259	Hyperlipoproteinemia Type III	4.2%
260	Xeroderma	4.2%
261	Mobius Syndrome	4.2%
262	Glycogen Storage Disease Type I	4.1%
263	Glycogen Storage Disease Type V	4.1%
264	Basal Cell Nevus Syndrome	4%
265	Abdominal Cramps	4%
266	Abnormalities, Drug-Induced	4%
267	Amniotic Band Syndrome	4%
268	Asphyxia Neonatorum	4%
269	Infant, Premature, Diseases	4%
270	Situs Inversus	4%
271	Infantile Colic	4%
272	Behcet Syndrome	4%
273	Splenosis	3.8%
274	Hodgkin Disease	3.8%
275	Lymphoma, Non-Hodgkin	3.8%
276	Leukemia, T-Cell	3.7%
277	Leukemia, B-Cell	3.7%
278	Familial Periodic Paralysis	3.7%
279	Lactose Intolerance	3.7%
280	Variegate Porphyria	3.7%
281	Acute intermittent porphyria	3.7%
282	Porphyria Cutanea Tarda	3.7%
283	Klinefelter Syndrome	3.7%
284	Hyperhomocysteinemia	3.7%
285	Renal Aminoacidurias	3.7%
286	Fanconi Syndrome	3.7%
287	Pseudohypoaldosteronism	3.7%
288	Liddle Syndrome	3.7%
289	Hyperlipoproteinemia Type IV	3.7%
290	Hyperlipoproteinemia Type V	3.7%
291	Huntington Disease	3.6%
292	Hypoalphalipoproteinemias	3.5%
293	Eye Abnormalities	3.5%
294	Cardiovascular Abnormalities	3.5%
295	Turner Syndrome	3.4%
296	Skin Abnormalities	3.4%
297	Congenital Microtia	3.4%
298	Persistent Fetal Circulation Syndrome	3.4%
299	Congenital diaphragmatic hernia	3.3%
300	Umbilical hernia	3.3%
301	Gout	3.3%
302	Anencephaly	3.3%
303	Multiple Endocrine Neoplasia Type 1	3.3%
304	Pseudohypoparathyroidism	3.3%
305	Composite Lymphoma	3.3%
306	Nephroblastoma	3.3%
307	Friedreich Ataxia	3.3%
308	Lymphangioleiomyomatosis	3.3%
309	Renal tubular acidosis	3.3%
310	Hypokalemic periodic paralysis	3.1%
311	Cystinuria	3%
312	Lymphoma, Follicular	3%
313	T-Cell Lymphoma	3%
314	Mantle cell lymphoma	3%
315	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3%
316	Leukemia, Large Granular Lymphocytic	3%
317	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3%
318	Adenomatous Polyposis Coli	3%
319	Familial Hypophosphatemic Rickets	3%
320	Urogenital Abnormalities	3%
321	Neonatal Abstinence Syndrome	2.9%
322	Maxillofacial Abnormalities	2.9%
323	Dural Arteriovenous Fistula	2.9%
324	Dextrocardia	2.9%
325	Fetal Growth Retardation	2.9%
326	Fetal Hypoxia	2.9%
327	Congenital nystagmus	2.9%
328	Fetal Alcohol Spectrum Disorders	2.9%
329	Toxoplasmosis, Congenital	2.8%
330	Syphilis, Congenital	2.8%
331	Arthritis, Gouty	2.7%
332	Lymphoma, T-Cell, Cutaneous	2.7%
333	Lymphoma, AIDS-Related	2.7%
334	Enteropathy-Associated T-Cell Lymphoma	2.7%
335	Primary Effusion Lymphoma	2.7%
336	Glycosuria, Renal	2.7%
337	Prune Belly Syndrome	2.6%
338	Twins, Conjoined	2.6%
339	Waardenburg Syndrome	2.6%
340	Congenital Hyperinsulinism	2.5%
341	Chorioamnionitis	2.5%
342	Mycosis Fungoides	2.5%
343	Lymphomatoid Papulosis	2.5%
344	Plasmablastic lymphoma	2.5%
345	Scimitar Syndrome	2.4%
346	Lymphomatoid Granulomatosis	2.4%
347	Denys-Drash Syndrome	2.3%
348	Acrocephalosyndactylia	2.3%
349	Microcephaly	2.2%
350	Macrocephaly	2.2%
351	MELAS Syndrome	2.2%
352	Anophthalmos	2.2%
353	Anus, Imperforate	2.2%
354	Hydranencephaly	2.2%
355	Microphthalmos	2.2%
356	Neural Tube Defects	2.2%
357	Paralysis, Obstetric	2.2%
358	Retinopathy of Prematurity	2.2%
359	Tethered Cord Syndrome	2.2%
360	Iniencephaly	2.2%
361	Craniorachischisis	2.2%
362	Limb Deformities, Congenital	2.2%
363	Exencephaly	2.2%
364	Septo-Optic Dysplasia	2.2%
365	Craniofacial Abnormalities	2.2%
366	Cortical Dysplasia	2.2%
367	Malformations of Cortical Development	2.2%
368	Anorectal Malformations	2.2%
369	Abnormalities, Radiation-Induced	2.2%
370	Bloom Syndrome	2.2%
371	Bronchopulmonary Dysplasia	2.2%
372	Craniosynostosis	2.2%
373	Syndactyly	2.2%
374	Brachycephaly	2.2%
375	Burkitt Lymphoma	2.1%
376	Porencephaly	2%
377	Noonan Syndrome	2%
378	Ophthalmia Neonatorum	2%
379	Cleft Palate	1.9%
380	Blepharophimosis	1.9%
381	Laryngostenosis	1.9%
382	Mouth Abnormalities	1.9%
383	Respiratory Distress Syndrome, Newborn	1.9%
384	Esophageal Atresia	1.9%
385	Intestinal Atresia	1.9%
386	Horseshoe Kidney	1.9%
387	Pectus excavatum	1.9%
388	Klippel-Feil Syndrome	1.9%
389	Gastroschisis	1.9%
390	Synostosis	1.9%
391	Acrodermatitis	1.9%
392	Gianotti-Crosti Syndrome	1.9%
393	Jaw Abnormalities	1.8%
394	Poland Syndrome	1.8%
395	Arthrogryposis	1.7%
396	Choanal Atresia	1.7%
397	Tracheobronchomegaly	1.7%
398	Laryngocele	1.7%
399	Choledochal Cyst	1.7%
400	Hermaphroditism	1.7%
401	Disorders of Sex Development	1.7%
402	Cryptorchidism	1.7%
403	Hypospadias	1.7%
404	Central Nervous System Cysts	1.7%
405	Dandy-Walker Syndrome	1.7%
406	Amelia	1.6%
407	Arachnodactyly	1.6%
408	Ectopia Cordis	1.6%
409	Ectromelia	1.6%
410	Hemimelia	1.6%
411	Meningomyelocele	1.6%
412	Phocomelia	1.6%
413	Sirenomelia	1.6%
414	Spina Bifida	1.6%
415	Polydactyly	1.6%
416	Brachydactyly	1.6%
417	Plagiocephaly	1.6%
418	Lower Extremity Deformities, Congenital	1.6%
419	Upper Extremity Deformities, Congenital	1.6%
420	Single umbilical artery	1.6%
421	Leukomalacia, Periventricular	1.6%
422	Nesidioblastosis	1.6%
423	Micrognathism	1.5%
424	Pierre Robin Syndrome	1.5%
425	Laryngomalacia	1.5%
426	Pectus carinatum	1.5%
427	Bladder Exstrophy	1.5%
428	Epispadias	1.5%
429	Multicystic Dysplastic Kidney	1.5%
430	Aortic coarctation	1.4%
431	Cor Triatriatum	1.4%
432	Coronary Vessel Anomalies	1.4%
433	Dental Enamel Hypoplasia	1.4%
434	Patent ductus arteriosus	1.4%
435	Ebstein Anomaly	1.4%
436	Heart Septal Defects	1.4%
437	Hyaline Membrane Disease	1.4%
438	Hypodontia	1.4%
439	Macrostomia	1.4%
440	Meningocele	1.4%
441	Microstomia	1.4%
442	Tetralogy of Fallot	1.4%
443	Transposition of Great Vessels	1.4%
444	Hypoplastic Left Heart Syndrome	1.4%
445	May-Thurner Syndrome	1.4%
446	Encephalocele	1.4%
447	Retrognathia	1.4%
448	Craniofacial Dysostosis	1.4%
449	Wolff-Parkinson-White Syndrome	1.4%
450	Dermal Sinus	1.4%
451	Spina Bifida Cystica	1.4%
452	Spina Bifida Occulta	1.4%
453	Lissencephaly	1.4%
454	Polymicrogyria	1.4%
455	Pachygyria	1.4%
456	Schizencephaly	1.4%
457	Periventricular Nodular Heterotopia	1.4%
458	Hyperandrogenism	1.3%
459	Prognathism	1.3%
460	Long QT Syndrome	1.2%
461	Platybasia	1.2%
462	Tricuspid Atresia	1.2%
463	Arrhythmogenic Right Ventricular Dysplasia	1.2%
464	Gonadal Dysgenesis	1.2%
465	Bronchomalacia	1.2%
466	Adrenogenital Syndrome	1.2%
467	Tracheomalacia	1.2%
468	Ovotesticular Disorders of Sex Development	1.2%
469	Aortopulmonary Septal Defect	1.2%
470	Double Outlet Right Ventricle	1.2%
471	Endocardial Cushion Defects	1.2%
472	Myocardial bridging	1.2%
473	Aorticopulmonary Septal Defect	1.2%
474	Truncus Arteriosus, Persistent	1%
475	Goldenhar Syndrome	1%
476	Mandibulofacial Dysostosis	1%
477	Romano-Ward Syndrome	1%
478	Talipes	0.9%
479	Congenital clubfoot	0.9%
480	Vertical Talus	0.9%
481	Arteriovenous fistula	0.8%

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