MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperlipoproteinemia Type IV

(UMLS:C0020480)

Definition:: A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
UMLS ID:: C0020480
MeSH ID:: D006953

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.487

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.500.644.490|C18.452.584.500.500.851.500|C18.452.648.398.487

Synonym(s)

Hyperlipoproteinemia Type IV

Carbohydrate induced hyperlipoproteinemia

Endogenous hyperlipemia

Endogenous hyperlipidemia

Familial hypertriglyceridaemia

Familial hypertriglyceridemia

Frederickson type IV hyperlipidemia

Frederickson; IV

Fredrickson Type IV Lipidemia

10.

Fredrickson type IV hyperlipoproteinaemia

11.

Fredrickson type IV hyperlipoproteinemia

12.

Fredrickson type IV lipidaemia

13.

Fredrickson type IV lipidemia

14.

Fredrickson; type IV hyperlipoproteinemia

15.

HYPERLIPIDEMIA TYPE IV

16.

HYPERLIPOPROTEINEMIA TYPE IV

17.

HYPERLIPOPROTEINEMIA, TYPE IV

18.

HYPERPREBETALIPOPROTEINEMIA

19.

HYPERTRIGLYCERIDEMIA, FAMILIAL

20.

Hyperlipoproteinemia, Frederickson type IV

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Clofibrate	417937	CTD
2	Fenofibrate	4004987	CTD
3	Gemfibrozil	2903970	CTD
4	alfibrate	1006248	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemia Type V	67.3%
2	Hyperlipidemia, Familial Combined	54.1%
3	Hyperlipoproteinemia Type III	53.9%
4	Hypolipoproteinemias	50.8%
5	Smith-Lemli-Opitz Syndrome	48.1%
6	Hypoalphalipoproteinemias	34.8%
7	Hypercholesterolemia	32.5%
8	Brain Diseases, Metabolic, Inborn	31.6%
9	Amino Acid Metabolism, Inborn Errors	29.9%
10	Carbohydrate Metabolism, Inborn Errors	29.9%
11	Metal Metabolism, Inborn Errors	29.9%
12	Progeria	29.9%
13	Lysosomal Storage Diseases	29.9%
14	Peroxisomal Disorders	29.9%
15	Wasting Syndrome	29.8%
16	Neuronal Ceroid-Lipofuscinoses	29.3%
17	Lipodystrophy	29.2%
18	Pseudohypoparathyroidism	29%
19	Leigh Disease	28.3%
20	Galactosemias	27.1%
21	Urea Cycle Disorders, Inborn	27.1%
22	Tyrosinemias	27.1%
23	Acid-Base Imbalance	26.4%
24	Calcium Metabolism Disorders	26.4%
25	Iron Metabolism Disorders	26.4%
26	Phosphorus Metabolism Disorders	26.4%
27	Water-Electrolyte Imbalance	26.4%
28	Mitochondrial Diseases	26.4%
29	Glucose Metabolism Disorders	26.4%
30	Xanthomatosis	26%
31	Xanthoma	26%
32	Gaucher Disease	25.1%
33	Hyperphosphaturia	24.6%
34	Hypercalcemia	24.3%
35	Hypocalcemia	24.3%
36	Milk-Alkali Syndrome	24.3%
37	Hyperhomocysteinemia	24.2%
38	Carbamoyl-Phosphate Synthase I Deficiency Disease	23.9%
39	Cytochrome-c Oxidase Deficiency	23.5%
40	Lactose Intolerance	23.3%
41	Glycogen storage disease type II	22.6%
42	Osteopenia	22.3%
43	Fabry Disease	22.3%
44	Menkes Kinky Hair Syndrome	22.2%
45	Brain Diseases, Metabolic	22.1%
46	Lipomatosis	22.1%
47	Homocystinuria	21.8%
48	Sjogren-Larsson Syndrome	21.6%
49	Adrenoleukodystrophy	21%
50	Werner Syndrome	20.4%
51	Zellweger Syndrome	20.3%
52	Hepatolenticular Degeneration	20.3%
53	Niemann-Pick Disease, Type C	19.9%
54	Refsum Disease	19.8%
55	Tay-Sachs Disease	19.6%
56	Rickets	19.1%
57	Alkaptonuria	18.9%
58	Glycogen Storage Disease	18.9%
59	Hypophosphatasia	18.9%
60	Propionic acidemia	18.9%
61	Dihydropyrimidine Dehydrogenase Deficiency	18.9%
62	Cystinosis	18.9%
63	Hyperlipoproteinemia Type IV	18.3%
64	Amyloid Neuropathies, Familial	18.3%
65	Mucopolysaccharidosis III	18.1%
66	Hyperlipoproteinemias	17.7%
67	Hypertriglyceridemia	17.7%
68	Familial Hypophosphatemic Rickets	17.6%
69	Renal tubular acidosis	17.4%
70	Nutrition Disorders	17.1%
71	Mucopolysaccharidosis II	16.8%
72	Albinism	15.9%
73	Ichthyosis, X-Linked	14.6%
74	Acidosis	14.5%
75	Alkalosis	14.5%
76	Amyloidosis	14.5%
77	Calcinosis	14.5%
78	Hyperglycemia	14.5%
79	Hyperinsulinism	14.5%
80	Hyperkalemia	14.5%
81	Hypernatremia	14.5%
82	Hypoglycemia	14.5%
83	Hypokalemia	14.5%
84	Hyponatremia	14.5%
85	Hypophosphatemia	14.5%
86	Metabolic acidosis	14.5%
87	Iron Overload	14.5%
88	Familial Periodic Paralysis	14.5%
89	MELAS Syndrome	14.3%
90	Glycosuria, Renal	14.3%
91	Renal Aminoacidurias	14.2%
92	Fanconi Syndrome	14.2%
93	Pseudohypoaldosteronism	14.2%
94	Liddle Syndrome	14.2%
95	Cockayne Syndrome	14.2%
96	Bloom Syndrome	13.7%
97	Glycogen Storage Disease Type I	13.5%
98	Glycogen Storage Disease Type V	13.5%
99	Antley-Bixler Syndrome Phenotype	13.4%
100	Congenital Hyperinsulinism	13.1%
101	Porphyrias, Hepatic	12.9%
102	Mitochondrial Encephalomyopathies	12.9%
103	Gout	12.9%
104	Fanconi Anemia	12.7%
105	Adiposis Dolorosa	12.6%
106	Diabetes Mellitus	12.5%
107	Dehydration	12.3%
108	Water Intoxication	12.3%
109	Achlorhydria	12.1%
110	Osteoporosis	12.1%
111	Bone Demineralization, Pathologic	12.1%
112	Post-Traumatic Osteoporosis	12.1%
113	Celiac Disease	12.1%
114	Sprue, Tropical	12.1%
115	Steatorrhea	12.1%
116	Sprue	12.1%
117	HIV-Associated Lipodystrophy Syndrome	11.9%
118	Canavan Disease	11.7%
119	Alexander Disease	11.7%
120	Osteomalacia	11.5%
121	Ataxia Telangiectasia	11.3%
122	HIV Wasting Syndrome	10.8%
123	Mitochondrial Myopathies	10.5%
124	Myelinolysis, Central Pontine	10.5%
125	Glycosuria	10.4%
126	Reye Syndrome	10.4%
127	Hepatic Encephalopathy	10.3%
128	Diabetic Ketoacidosis	10.3%
129	Hypokalemic periodic paralysis	10.2%
130	Friedreich Ataxia	10.2%
131	Cystinuria	10.1%
132	Optic Atrophy, Hereditary, Leber	10.1%
133	Lipid Metabolism Disorders	9.8%
134	Xeroderma Pigmentosum	9.5%
135	Necrobiosis Lipoidica Diabeticorum	9.1%
136	Arthritis, Gouty	9.1%
137	Child Nutrition Disorders	8.8%
138	Hypervitaminosis A	8.8%
139	Infant Nutrition Disorders	8.8%
140	Malnutrition	8.8%
141	Wernicke Encephalopathy	8.8%
142	Acidosis, Lactic	8.6%
143	Calciphylaxis	8.6%
144	Hemosiderosis	8.6%
145	Ketosis	8.6%
146	Ketonuria	8.6%
147	Ketoacidosis	8.6%
148	Ketonemia	8.6%
149	Vascular calcification	8.6%
150	Neoplastic Syndromes, Hereditary	8.5%
151	Nesidioblastosis	8.5%
152	Renal Osteodystrophy	8.4%
153	Renal rickets	8.4%
154	CHARGE Syndrome	8.4%
155	Cystic Fibrosis	8.4%
156	Kernicterus	8.4%
157	Aicardi's syndrome	8.3%
158	Multiple Epiphyseal Dysplasia	8.2%
159	Osteochondrodysplasias	8.2%
160	Pelger-Huet Anomaly	8.2%
161	Myasthenic Syndromes, Congenital	8.2%
162	Variegate Porphyria	7.8%
163	Acute intermittent porphyria	7.8%
164	Porphyria Cutanea Tarda	7.8%
165	Nail-Patella Syndrome	7.5%
166	Anemia, Sickle Cell	7.3%
167	Thalassemia	7.3%
168	Muscular Dystrophy, Duchenne	7.3%
169	Acidosis, Respiratory	7.2%
170	Alkalosis, Respiratory	7.2%
171	Dwarfism	7.2%
172	Kearns-Sayre syndrome	7.2%
173	Insulin Resistance	7.2%
174	Osteoporosis, Postmenopausal	7.2%
175	Fragile X Syndrome	7.1%
176	Prader-Willi Syndrome	7%
177	Muscular Dystrophy	7%
178	Osteogenesis Imperfecta	7%
179	Beckwith-Wiedemann Syndrome	7%
180	Wolf-Hirschhorn Syndrome	7%
181	Gestational Diabetes	6.4%
182	Latent Autoimmune Diabetes in Adults	6.4%
183	Diabetes Mellitus, Experimental	6.3%
184	Alstrom Syndrome	6.2%
185	Autoimmune Lymphoproliferative Syndrome	6.2%
186	Nephrocalcinosis	6.2%
187	Tetany	6.2%
188	Smith-Magenis syndrome	6.2%
189	Cerebral Amyloid Angiopathy	6.1%
190	Cri-du-Chat Syndrome	6.1%
191	Down Syndrome	6.1%
192	Angioedemas, Hereditary	6.1%
193	Trisomy 21	6.1%
194	Deformity	6%
195	Marfan Syndrome	6%
196	Kartagener Syndrome	6%
197	Wiskott-Aldrich Syndrome	5.8%
198	Familial Mediterranean Fever	5.8%
199	Dyslipidemias	5.8%
200	Holoprosencephaly	5.6%
201	Rett Syndrome	5.5%
202	Primary amyloidosis	5.5%
203	Ectodermal Dysplasia	5.4%
204	Aplasia Cutis Congenita	5.4%
205	Kallmann Syndrome	5.3%
206	Myotonic Dystrophy	5.3%
207	Fetal Diseases	5.1%
208	Rubinstein-Taybi Syndrome	5%
209	Tuberous Sclerosis	5%
210	Amyotrophic Lateral Sclerosis	4.9%
211	Polycystic Kidney Diseases	4.8%
212	Williams Syndrome	4.8%
213	Deficiency Diseases	4.8%
214	Starvation	4.8%
215	Refeeding Syndrome	4.8%
216	Sickle Cell Trait	4.8%
217	Primary Ciliary Dyskinesia	4.7%
218	Retinal Dysplasia	4.5%
219	Aniridia	4.4%
220	Epidermolysis Bullosa	4.4%
221	CREST Syndrome	4.3%
222	Cutis Laxa	4.2%
223	Retinitis Pigmentosa	4.2%
224	Pigmentary retinopathy	4.2%
225	Porokeratosis	4.2%
226	Keratoderma, Palmoplantar	4.2%
227	Chronic granulomatous disease	4.2%
228	Welander Distal Myopathy	4.1%
229	Acute Chest Syndrome	3.9%
230	Duane Retraction Syndrome	3.7%
231	Meconium Aspiration Syndrome	3.7%
232	Peutz-Jeghers Syndrome	3.7%
233	Myotonia Congenita	3.7%
234	Thrombasthenia	3.7%
235	Antithrombin III Deficiency	3.7%
236	Protein C Deficiency	3.7%
237	Afibrinogenemia	3.6%
238	Dystonia Musculorum Deformans	3.6%
239	Factor VII Deficiency	3.6%
240	Factor X Deficiency	3.6%
241	Factor XII Deficiency	3.6%
242	Hemophilia A	3.6%
243	Activated Protein C Resistance	3.6%
244	Factor II deficiency	3.6%
245	Factor VIII Deficiency	3.6%
246	Factor V deficiency	3.6%
247	Factor XI Deficiency	3.6%
248	Hypoprothrombinemias	3.6%
249	Lafora Disease	3.6%
250	Unverricht-Lundborg Syndrome	3.6%
251	Anemia, Diamond-Blackfan	3.6%
252	Frontotemporal dementia	3.6%
253	Pseudoxanthoma Elasticum	3.6%
254	Multiple Endocrine Neoplasia	3.3%
255	Xeroderma	3.3%
256	Mobius Syndrome	3.3%
257	Congenital Hypothyroidism	3.3%
258	Dermatitis, Atopic	3.3%
259	Abdominal Cramps	3.3%
260	Abnormalities, Drug-Induced	3.3%
261	Amniotic Band Syndrome	3.3%
262	Asphyxia Neonatorum	3.3%
263	Infant, Premature, Diseases	3.3%
264	Situs Inversus	3.3%
265	Infantile Colic	3.3%
266	Polycystic Kidney, Autosomal Dominant	3.2%
267	Classical Lissencephalies and Subcortical Band Heterotopias	3.1%
268	Hyperkeratosis, Epidermolytic	3%
269	Basal Cell Nevus Syndrome	3%
270	Obesity	3%
271	Behcet Syndrome	2.9%
272	Kwashiorkor	2.9%
273	Magnesium Deficiency	2.9%
274	Potassium Deficiency	2.9%
275	Protein Deficiency	2.9%
276	Avitaminosis	2.9%
277	Charcot-Marie-Tooth Disease	2.9%
278	Eye Abnormalities	2.8%
279	Cardiovascular Abnormalities	2.8%
280	Skin Abnormalities	2.8%
281	Lymphatic Abnormalities	2.8%
282	Congenital Microtia	2.8%
283	Papillon-Lefevre Disease	2.7%
284	Anemia, Neonatal	2.7%
285	Persistent Fetal Circulation Syndrome	2.7%
286	Congenital diaphragmatic hernia	2.7%
287	Umbilical hernia	2.7%
288	Huntington Disease	2.7%
289	Urogenital Abnormalities	2.4%
290	Nephroblastoma	2.4%
291	Neonatal Abstinence Syndrome	2.4%
292	Fetal Growth Retardation	2.3%
293	Fetal Hypoxia	2.3%
294	Congenital nystagmus	2.3%
295	Fetal Alcohol Spectrum Disorders	2.3%
296	Toxoplasmosis, Congenital	2.3%
297	Anencephaly	2.3%
298	Syphilis, Congenital	2.3%
299	Adenomatous Polyposis Coli	2.2%
300	Hydrops Fetalis	2.2%
301	Klinefelter Syndrome	2.2%
302	Multiple Endocrine Neoplasia Type 1	2.2%
303	Turner Syndrome	2.1%
304	Chorioamnionitis	2%
305	Maxillofacial Abnormalities	2%
306	Dural Arteriovenous Fistula	2%
307	Obesity, Abdominal	2%
308	Dextrocardia	2%
309	Prune Belly Syndrome	1.9%
310	Twins, Conjoined	1.9%
311	Waardenburg Syndrome	1.9%
312	Ascorbic Acid Deficiency	1.9%
313	Vitamin A Deficiency	1.9%
314	Vitamin D Deficiency	1.9%
315	Vitamin E Deficiency	1.9%
316	Marasmus	1.9%
317	Abnormalities, Radiation-Induced	1.8%
318	Pediatric Obesity	1.8%
319	Scimitar Syndrome	1.7%
320	Anophthalmos	1.6%
321	Anus, Imperforate	1.6%
322	Hydranencephaly	1.6%
323	Microphthalmos	1.6%
324	Neural Tube Defects	1.6%
325	Paralysis, Obstetric	1.6%
326	Retinopathy of Prematurity	1.6%
327	Tethered Cord Syndrome	1.6%
328	Iniencephaly	1.6%
329	Craniorachischisis	1.6%
330	Limb Deformities, Congenital	1.6%
331	Exencephaly	1.6%
332	Septo-Optic Dysplasia	1.6%
333	Craniofacial Abnormalities	1.6%
334	Cortical Dysplasia	1.6%
335	Malformations of Cortical Development	1.6%
336	Anorectal Malformations	1.6%
337	Ophthalmia Neonatorum	1.6%
338	Bronchopulmonary Dysplasia	1.6%
339	Denys-Drash Syndrome	1.5%
340	Craniosynostosis	1.4%
341	Syndactyly	1.4%
342	Brachycephaly	1.4%
343	Folic Acid Deficiency	1.4%
344	Pellagra	1.4%
345	Thiamine Deficiency	1.4%
346	Vitamin B 12 Deficiency	1.4%
347	Vitamin B 6 Deficiency	1.4%
348	Pyridoxine Deficiency	1.4%
349	Blepharophimosis	1.4%
350	Laryngostenosis	1.4%
351	Mouth Abnormalities	1.4%
352	Respiratory Distress Syndrome, Newborn	1.4%
353	Microcephaly	1.4%
354	Macrocephaly	1.4%
355	Esophageal Atresia	1.4%
356	Intestinal Atresia	1.4%
357	Horseshoe Kidney	1.4%
358	Pectus excavatum	1.4%
359	Klippel-Feil Syndrome	1.4%
360	Gastroschisis	1.4%
361	Synostosis	1.4%
362	Acrodermatitis	1.4%
363	Lymphangiectasis, Intestinal	1.4%
364	Gianotti-Crosti Syndrome	1.4%
365	Vitamin K Deficiency	1.4%
366	Acrocephalosyndactylia	1.4%
367	Noonan Syndrome	1.3%
368	Arthrogryposis	1.3%
369	Choanal Atresia	1.3%
370	Tracheobronchomegaly	1.3%
371	Laryngocele	1.3%
372	Choledochal Cyst	1.2%
373	Hermaphroditism	1.2%
374	Disorders of Sex Development	1.2%
375	Cryptorchidism	1.2%
376	Hypospadias	1.2%
377	Central Nervous System Cysts	1.2%
378	Dandy-Walker Syndrome	1.2%
379	Leukomalacia, Periventricular	1.2%
380	POEMS Syndrome	1.2%
381	Porencephaly	1.2%
382	Beriberi	1.2%
383	Cleft Palate	1.2%
384	Jaw Abnormalities	1.1%
385	Laryngomalacia	1.1%
386	Pectus carinatum	1.1%
387	Bladder Exstrophy	1.1%
388	Epispadias	1.1%
389	Multicystic Dysplastic Kidney	1.1%
390	Amelia	1.1%
391	Arachnodactyly	1.1%
392	Ectopia Cordis	1.1%
393	Ectromelia	1.1%
394	Hemimelia	1.1%
395	Meningomyelocele	1.1%
396	Phocomelia	1.1%
397	Sirenomelia	1.1%
398	Spina Bifida	1.1%
399	Polydactyly	1.1%
400	Brachydactyly	1.1%
401	Plagiocephaly	1.1%
402	Lower Extremity Deformities, Congenital	1.1%
403	Upper Extremity Deformities, Congenital	1.1%
404	Single umbilical artery	1.1%
405	Poland Syndrome	1.1%
406	Scurvy	1%
407	Anemia, Pernicious	1%
408	Aortic coarctation	0.9%
409	Cor Triatriatum	0.9%
410	Coronary Vessel Anomalies	0.9%
411	Dental Enamel Hypoplasia	0.9%
412	Patent ductus arteriosus	0.9%
413	Ebstein Anomaly	0.9%
414	Heart Septal Defects	0.9%
415	Hyaline Membrane Disease	0.9%
416	Hypodontia	0.9%
417	Macrostomia	0.9%
418	Meningocele	0.9%
419	Microstomia	0.9%
420	Tetralogy of Fallot	0.9%
421	Transposition of Great Vessels	0.9%
422	Hypoplastic Left Heart Syndrome	0.9%
423	May-Thurner Syndrome	0.9%
424	Encephalocele	0.9%
425	Craniofacial Dysostosis	0.9%
426	Wolff-Parkinson-White Syndrome	0.9%
427	Micrognathism	0.9%
428	Pierre Robin Syndrome	0.9%
429	Long QT Syndrome	0.8%
430	Platybasia	0.8%
431	Tricuspid Atresia	0.8%
432	Arrhythmogenic Right Ventricular Dysplasia	0.8%
433	Gonadal Dysgenesis	0.8%
434	Bronchomalacia	0.8%
435	Adrenogenital Syndrome	0.8%
436	Tracheomalacia	0.8%
437	Ovotesticular Disorders of Sex Development	0.8%
438	Retrognathia	0.8%
439	Hyperandrogenism	0.8%
440	Dermal Sinus	0.8%
441	Spina Bifida Cystica	0.8%
442	Spina Bifida Occulta	0.8%
443	Lissencephaly	0.8%
444	Polymicrogyria	0.8%
445	Pachygyria	0.8%
446	Schizencephaly	0.8%
447	Periventricular Nodular Heterotopia	0.8%
448	Prognathism	0.7%
449	Subacute Combined Degeneration	0.7%
450	Aortopulmonary Septal Defect	0.7%
451	Double Outlet Right Ventricle	0.7%
452	Endocardial Cushion Defects	0.7%
453	Myocardial bridging	0.7%
454	Aorticopulmonary Septal Defect	0.7%
455	Mandibulofacial Dysostosis	0.6%
456	Romano-Ward Syndrome	0.6%
457	Truncus Arteriosus, Persistent	0.6%
458	Goldenhar Syndrome	0.6%
459	Talipes	0.5%
460	Arteriovenous fistula	0.5%
461	Congenital clubfoot	0.4%
462	Vertical Talus	0.4%

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