MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Friedreich Ataxia

(UMLS:C0016719)

Definition:: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
UMLS ID:: C0016719
MeSH ID:: D005621

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.252.700.150|C10.228.854.787.200|C10.574.500.825.200

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.780.200

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.660.300

Synonym(s)

Friedreich Ataxia

FA - Friedreich ataxia

FRIEDREICH ATAXIA

FRIEDREICHS ATAXIA

Familial ataxia

Friedreich ataxia

Friedreich's Ataxia

Friedreich's ataxia

Friedreich's disease

10.

Friedreich; ataxia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Betamethasone	23418481	CTD
2	Camptothecin	23418481	CTD
3	Deferiprone	23418481	CTD
4	Molsidomine	23418481	CTD
5	Nimustine	23418481	CTD
6	Resveratrol	23418481	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Dystonia Musculorum Deformans	28.4%
2	Hepatolenticular Degeneration	28.1%
3	Multiple System Atrophy	26%
4	Amyotrophic Lateral Sclerosis	25.5%
5	Huntington Disease	25.4%
6	Meningoencephalitis	25.3%
7	Encephalomyelitis	24.9%
8	Canavan Disease	24.5%
9	Alexander Disease	24.5%
10	Dandy-Walker Syndrome	24.2%
11	Subacute Combined Degeneration	24%
12	Myelitis	23.8%
13	Lafora Disease	23.5%
14	Unverricht-Lundborg Syndrome	23.5%
15	Epidural Abscess	23%
16	Amyloid Neuropathies, Familial	22.4%
17	Lewy Body Disease	22.4%
18	Stiff-Person Syndrome	22.4%
19	Brain Diseases, Metabolic	22.4%
20	Spinal Muscular Atrophy	22.3%
21	Progressive Muscular Atrophy	22.3%
22	Neuronal Ceroid-Lipofuscinoses	22.2%
23	Cockayne Syndrome	21.3%
24	Pneumocephalus	20.9%
25	Prion Diseases	20.7%
26	Leigh Disease	20.7%
27	Ocular Motility Disorders	20.5%
28	Cyclophoria	20.5%
29	Parkinson Disease	20.4%
30	Refsum Disease	19.8%
31	Adrenoleukodystrophy	19.5%
32	Subdural Effusion	19.5%
33	Spinal Cord Injuries	19.5%
34	Myotonia Congenita	19.2%
35	Optic Atrophy, Hereditary, Leber	18.8%
36	Brain Diseases, Metabolic, Inborn	18.7%
37	Carbamoyl-Phosphate Synthase I Deficiency Disease	18.7%
38	Tuberous Sclerosis	18.6%
39	Mitochondrial Encephalomyopathies	18.5%
40	Motor Neuron Disease	18.5%
41	Myelinolysis, Central Pontine	18.5%
42	Meningitis	18.4%
43	Movement Disorders	18.4%
44	Pachymeningitis	18.4%
45	Myotonic Dystrophy	17.9%
46	Brain Abscess	17.9%
47	Dementia, Vascular	17.7%
48	Parkinsonian Disorders	17.6%
49	Cytochrome-c Oxidase Deficiency	17.2%
50	Poliomyelitis	17.2%
51	Progressive supranuclear palsy	17.2%
52	Syringomyelia	17.1%
53	Pneumorrhachis	17.1%
54	Cerebellar Neoplasms	16.9%
55	Ataxia Telangiectasia	16.9%
56	MELAS Syndrome	16.4%
57	Striatonigral Degeneration	16.4%
58	Menkes Kinky Hair Syndrome	16.4%
59	Spinal Cord Neoplasms	16.3%
60	Paraneoplastic Cerebellar Degeneration	16.3%
61	Central Nervous System Infection	16.2%
62	Myelitis, Transverse	16.2%
63	Akinetic Mutism	16%
64	Anoxic Encephalopathy	16%
65	Basal Ganglia Diseases	16%
66	Brain Damage, Chronic	16%
67	Encephalitis	16%
68	Encephalomalacia	16%
69	Epilepsy	16%
70	Hydrocephalus	16%
71	Congenital Hydrocephalus	16%
72	Hypothalamic Diseases	16%
73	Thalamic Diseases	16%
74	Intracranial Hypertension	16%
75	Aura	16%
76	Leukoencephalopathy	16%
77	Neuroaxonal Dystrophies	16%
78	Headache Disorders	16%
79	Intracranial Hypotension	16%
80	Brain Edema	16%
81	Brain Hypoxia	16%
82	Aqueductal Stenosis	16%
83	Brain Injuries	15.5%
84	Brain Neoplasms	15.5%
85	Marchiafava-Bignami Disease	15.5%
86	Epilepsy, Post-Traumatic	15.3%
87	Galactosemias	15.2%
88	Urea Cycle Disorders, Inborn	15.2%
89	Tyrosinemias	15.2%
90	Mitochondrial Myopathies	15.1%
91	Basal Ganglia Cerebrovascular Disease	15%
92	Charcot-Marie-Tooth Disease	14.9%
93	Cranial nerve diseases	14.8%
94	Demyelinating Diseases	14.8%
95	Demyelination	14.8%
96	Neuromuscular Diseases	14.8%
97	Chronobiology Disorders	14.8%
98	Conus Medullaris Syndrome	14.8%
99	Spinal Cord Vascular Diseases	14.8%
100	Limbic Encephalitis	14.8%
101	Shy-Drager Syndrome	14.8%
102	Miller Fisher Syndrome	14.7%
103	Alstrom Syndrome	14.6%
104	Cerebellar Ataxia	14.5%
105	Posterior Leukoencephalopathy Syndrome	14.5%
106	Posterior reversible encephalopathy syndrome	14.5%
107	Leukomalacia, Periventricular	14.5%
108	Leukoencephalopathy, Progressive Multifocal	14.4%
109	Fabry Disease	14.4%
110	Meige Syndrome	14.3%
111	Cerebral Ventriculitis	14.3%
112	Asterixis	14%
113	Ballismus	14%
114	Cerebrovascular Disorders	13.9%
115	Cerebrovascular Insufficiency	13.9%
116	Dementia	13.9%
117	Lupus Vasculitis, Central Nervous System	13.9%
118	Ophthalmoplegic Migraine	13.7%
119	Neuroleptic Malignant Syndrome	13.6%
120	Restless Legs Syndrome	13.5%
121	Presenile dementia	13.4%
122	Senile dementia	13.4%
123	Tauopathies	13.4%
124	Brain Death	13.3%
125	Homocystinuria	13.2%
126	Glycogen storage disease type II	13.2%
127	Opsoclonus-Myoclonus Syndrome	13.2%
128	Trauma, Nervous System	13.1%
129	Meningitis, Bacterial	13%
130	Meningitis, Fungal	13%
131	Chronic Fatigue Syndrome	12.9%
132	Nervous System Neoplasms	12.8%
133	Neurologic Manifestations	12.8%
134	Neurotoxicity Syndromes	12.8%
135	Vascular Headaches	12.8%
136	Leukoencephalitis, Acute Hemorrhagic	12.7%
137	Amblyopia	12.7%
138	Pseudohypoparathyroidism	12.7%
139	Polyradiculoneuropathy	12.7%
140	Polyradiculoneuritis	12.7%
141	Werner Syndrome	12.7%
142	Hypoxia-Ischemia, Brain	12.7%
143	Creutzfeldt-Jakob disease	12.6%
144	Reye Syndrome	12.4%
145	Gaucher Disease	12.4%
146	Hepatic Encephalopathy	12.4%
147	Smith-Lemli-Opitz Syndrome	12.4%
148	Kearns-Sayre syndrome	12.3%
149	MPTP Poisoning	12.2%
150	Zellweger Syndrome	12%
151	Myoclonic Epilepsy	12%
152	Epilepsy, Temporal Lobe	12%
153	Epilepsy, Rolandic	12%
154	Benign Rolandic Epilepsy	12%
155	Central Cord Syndrome	11.9%
156	Mucopolysaccharidosis II	11.9%
157	Wasting Syndrome	11.4%
158	Sleep Wake Disorders	11.4%
159	Akathisia, Drug-Induced	11.3%
160	Lambert-Eaton Myasthenic Syndrome	11.2%
161	Hypercalcemia	11.2%
162	Hypocalcemia	11.2%
163	Milk-Alkali Syndrome	11.2%
164	Scrapie	11.1%
165	Myasthenic Syndromes, Congenital	11.1%
166	Tay-Sachs Disease	11%
167	Brain Diseases	11%
168	Vasculitis, Central Nervous System	10.9%
169	Amnesia, Transient Global	10.9%
170	Encephalomyelitis, Acute Disseminated	10.8%
171	Smith-Magenis syndrome	10.8%
172	Autonomic Dysreflexia	10.8%
173	Complex Regional Pain Syndromes	10.8%
174	Toxoplasmosis, Cerebral	10.8%
175	Frontotemporal dementia	10.7%
176	Progressive bulbar palsy	10.7%
177	Bulbar palsy	10.7%
178	Niemann-Pick Disease, Type C	10.7%
179	Dyskinesia, Drug-Induced	10.7%
180	Brain Hemorrhage, Traumatic	10.7%
181	Wernicke Encephalopathy	10.6%
182	Arachnoiditis	10.6%
183	Aseptic Meningitis	10.6%
184	Essential Tremor	10.6%
185	Familial Tremor	10.6%
186	Writer's Cramp	10.6%
187	Basal Ganglia Hemorrhage	10.6%
188	Familial Hypophosphatemic Rickets	10.5%
189	Hyperhomocysteinemia	10.5%
190	Hyperphosphaturia	10.5%
191	Fragile X Syndrome	10.3%
192	Paraneoplastic Encephalomyelitis	10.2%
193	Hyperlipoproteinemia Type IV	10.2%
194	Hyperlipoproteinemia Type V	10.2%
195	Carotid Artery Injuries	10.2%
196	Spinal Cord Diseases	10.1%
197	Aicardi's syndrome	10.1%
198	Kernicterus	10%
199	Cerebral Palsy	10%
200	Epilepsies, Partial	10%
201	Epilepsy, Generalized	10%
202	Pseudotumor Cerebri	10%
203	Hypertensive Encephalopathy	10%
204	Simple Partial Seizures	10%
205	Epilepsy, Reflex	10%
206	Headache Disorders, Primary	10%
207	Headache Disorders, Secondary	10%
208	Medication overuse headache	10%
209	Pituitary Adenoma	9.9%
210	Pituitary Neoplasms	9.9%
211	Acid-Base Imbalance	9.9%
212	Calcium Metabolism Disorders	9.9%
213	Iron Metabolism Disorders	9.9%
214	Phosphorus Metabolism Disorders	9.9%
215	Water-Electrolyte Imbalance	9.9%
216	Lipid Metabolism Disorders	9.9%
217	Glucose Metabolism Disorders	9.9%
218	Lipodystrophy	9.8%
219	Tuberculosis, Meningeal	9.8%
220	Amino Acid Metabolism, Inborn Errors	9.8%
221	Carbohydrate Metabolism, Inborn Errors	9.8%
222	Metal Metabolism, Inborn Errors	9.8%
223	Progeria	9.8%
224	Lysosomal Storage Diseases	9.8%
225	Peroxisomal Disorders	9.8%
226	Lactose Intolerance	9.7%
227	Hypolipoproteinemias	9.7%
228	Brain Injuries, Diffuse	9.7%
229	Traumatic Brain Injury	9.7%
230	Rett Syndrome	9.7%
231	Supratentorial Neoplasms	9.7%
232	Guillain-Barre Syndrome	9.6%
233	Peripheral Nerve Injuries	9.6%
234	Spinal Cord Ischemia	9.5%
235	Central Nervous System Cysts	9.5%
236	Rickets	9.5%
237	Myasthenia Gravis	9.5%
238	Juvenile Myoclonic Epilepsy	9.4%
239	Myoclonic Epilepsies, Progressive	9.4%
240	Pituitary Apoplexy	9.4%
241	Brain Infarction	9.3%
242	Central Nervous System Fungal Infections	9.2%
243	Hyperlipidemia, Familial Combined	9.1%
244	Persistent Vegetative State	9%
245	Albinism	9%
246	Ichthyosis, X-Linked	8.8%
247	Pituitary Diseases	8.8%
248	Hyperlipoproteinemia Type III	8.8%
249	Sleep Disorders, Circadian Rhythm	8.6%
250	Carotid Artery Diseases	8.6%
251	Brain Ischemia	8.6%
252	Cerebrovascular accident	8.6%
253	Kluver-Bucy Syndrome	8.6%
254	Vasospasm, Intracranial	8.6%
255	Intracranial Arterial Diseases	8.6%
256	Familial Periodic Paralysis	8.6%
257	Osteopenia	8.6%
258	Chorea	8.5%
259	Putaminal Hemorrhage	8.5%
260	Congenital Hyperinsulinism	8.4%
261	Muscular Dystrophy	8.4%
262	Botulism	8.4%
263	Neuromyelitis Optica	8.4%
264	Hydranencephaly	8.2%
265	Neural Tube Defects	8.2%
266	Tethered Cord Syndrome	8.2%
267	Iniencephaly	8.2%
268	Craniorachischisis	8.2%
269	Exencephaly	8.2%
270	Septo-Optic Dysplasia	8.2%
271	Cortical Dysplasia	8.2%
272	Malformations of Cortical Development	8.2%
273	Olfactory Nerve Injuries	8.1%
274	Infarction, Middle Cerebral Artery	8.1%
275	Infarction, Anterior Cerebral Artery	8.1%
276	Infarction, Posterior Cerebral Artery	8.1%
277	Sjogren-Larsson Syndrome	8.1%
278	Central Nervous System Bacterial Infections	8.1%
279	Dysautonomia	7.9%
280	Vagus Nerve Disorder	7.9%
281	Glossopharyngeal Neuralgia	7.9%
282	Abducens Nerve Diseases	7.9%
283	Heavy Metal Poisoning, Nervous System	7.9%
284	Neuromuscular Junction Diseases	7.9%
285	Trochlear Nerve Diseases	7.9%
286	Peripheral Nervous System Diseases	7.9%
287	Muscular Dystrophy, Duchenne	7.9%
288	Causalgia	7.9%
289	Hypoalphalipoproteinemias	7.8%
290	Renal tubular acidosis	7.7%
291	Cerebral Amyloid Angiopathy	7.7%
292	Meningitis, Cryptococcal	7.7%
293	Porphyrias, Hepatic	7.7%
294	Meningitis, Listeria	7.7%
295	Mucopolysaccharidosis III	7.7%
296	Subacute Sclerosing Panencephalitis	7.7%
297	Meningitis, Haemophilus	7.7%
298	Meningitis, Pneumococcal	7.7%
299	Prader-Willi Syndrome	7.7%
300	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.6%
301	Fanconi Anemia	7.6%
302	Intracranial Embolism and Thrombosis	7.5%
303	Cystic Fibrosis	7.5%
304	Holoprosencephaly	7.5%
305	Moyamoya Disease	7.5%
306	Cri-du-Chat Syndrome	7.4%
307	Down Syndrome	7.4%
308	Trisomy 21	7.4%
309	CHARGE Syndrome	7.4%
310	Facial Nerve Injuries	7.3%
311	Cerebral Infarction	7.3%
312	Brain Stem Infarctions	7.3%
313	Horner Syndrome	7.3%
314	Neoplastic Syndromes, Hereditary	7.3%
315	Torticollis	7.3%
316	Osteomalacia	7.2%
317	Dural Arteriovenous Fistula	7.1%
318	Tetany	7.1%
319	Auditory Perceptual Disorders	7.1%
320	Multiple Epiphyseal Dysplasia	7.1%
321	Osteochondrodysplasias	7.1%
322	Pelger-Huet Anomaly	7.1%
323	Myopathy	7%
324	Optic Neuropathy	7%
325	Bloom Syndrome	7%
326	Post-Traumatic Headache	7%
327	Tension Headache	7%
328	Epilepsy, Complex Partial	7%
329	Migraine Disorders	7%
330	Abdominal Migraine	7%
331	Status Migrainosus	7%
332	Cervicogenic Headache	7%
333	Vertebral Artery Dissection	7%
334	Subarachnoid Hemorrhage, Traumatic	7%
335	Carotid Artery, Internal, Dissection	7%
336	Alkaptonuria	6.9%
337	Glycogen Storage Disease	6.9%
338	Hypophosphatasia	6.9%
339	Propionic acidemia	6.9%
340	Dihydropyrimidine Dehydrogenase Deficiency	6.9%
341	Cystinosis	6.9%
342	Multiple Sclerosis	6.9%
343	Anterior Spinal Artery Syndrome	6.9%
344	Facial Nerve Diseases	6.9%
345	Craniocerebral Trauma	6.9%
346	Parasomnia	6.9%
347	Dyssomnias	6.9%
348	Diffuse Axonal Injury	6.8%
349	Vestibulocochlear Nerve Diseases	6.8%
350	Decerebrate State	6.8%
351	Hemiparesis	6.8%
352	Meningism	6.8%
353	Paresis	6.8%
354	Seizures	6.8%
355	Sensation Disorders	6.8%
356	Central Nervous System Neoplasms	6.8%
357	Complex partial seizures	6.8%
358	Monoparesis	6.8%
359	Neurogenic Inflammation	6.8%
360	Gait Disorders, Neurologic	6.8%
361	Neuromuscular Manifestations	6.8%
362	Brain Stem Neoplasms	6.8%
363	Sweating, Gustatory	6.8%
364	Auriculotemporal Syndrome	6.8%
365	Diabetic Ketoacidosis	6.7%
366	Nail-Patella Syndrome	6.7%
367	Myasthenia Gravis, Autoimmune, Experimental	6.6%
368	Brain Concussion	6.6%
369	Jet Lag Syndrome	6.6%
370	Anemia, Sickle Cell	6.5%
371	Thalassemia	6.5%
372	Acidosis	6.5%
373	Alkalosis	6.5%
374	Amyloidosis	6.5%
375	Calcinosis	6.5%
376	Cerebellar Diseases	6.5%
377	Hyperglycemia	6.5%
378	Hyperinsulinism	6.5%
379	Hyperkalemia	6.5%
380	Hypernatremia	6.5%
381	Hypoglycemia	6.5%
382	Hypokalemia	6.5%
383	Hyponatremia	6.5%
384	Xanthomatosis	6.5%
385	Hypophosphatemia	6.5%
386	Metabolic acidosis	6.5%
387	Dyslipidemias	6.5%
388	Iron Overload	6.5%
389	Xanthoma	6.5%
390	Reflex Sympathetic Dystrophy	6.5%
391	Nocturnal Myoclonus Syndrome	6.5%
392	Nesidioblastosis	6.5%
393	Duane Retraction Syndrome	6.5%
394	Glycosuria, Renal	6.4%
395	Dwarfism	6.3%
396	Williams Syndrome	6.3%
397	Lateral Medullary Syndrome	6.3%
398	Hypokalemic periodic paralysis	6.3%
399	Alice in Wonderland Syndrome	6.2%
400	Ophthalmoplegia	6.2%
401	External Ophthalmoplegia	6.2%
402	Osteogenesis Imperfecta	6.2%
403	Beckwith-Wiedemann Syndrome	6.1%
404	Wolf-Hirschhorn Syndrome	6.1%
405	Pupil Disorders	6.1%
406	Neurobehavioral Manifestations	6.1%
407	Rubinstein-Taybi Syndrome	6.1%
408	Xeroderma Pigmentosum	6.1%
409	Brain Contusion	6.1%
410	Empty Sella Syndrome	6.1%
411	Hyperpituitarism	6.1%
412	Hypopituitarism	6.1%
413	Hypophysitis	6.1%
414	Mobius Syndrome	6.1%
415	AIDS Dementia Complex	6%
416	Cerebral Arterial Diseases	6%
417	Vertebrobasilar Insufficiency	6%
418	Basilar Artery Stenosis	6%
419	Vertebral Artery Stenosis	6%
420	Intracranial Hemorrhage, Hypertensive	6%
421	Transient Cerebral Ischemia	6%
422	Uveomeningoencephalitic Syndrome	6%
423	Sturge-Weber Syndrome	6%
424	Vertigo	6%
425	Alcohol-Induced Disorders, Nervous System	6%
426	Classical Lissencephalies and Subcortical Band Heterotopias	5.9%
427	Tardive Dyskinesia	5.8%
428	West Nile Fever	5.8%
429	Giant Cell Arteritis	5.8%
430	Temporal Arteritis	5.8%
431	Diabetes Mellitus	5.8%
432	Tuberculosis, Central Nervous System	5.8%
433	Toxoplasmosis, Congenital	5.7%
434	Acrodynia	5.7%
435	Kartagener Syndrome	5.6%
436	Dehydration	5.6%
437	Lipomatosis	5.6%
438	Water Intoxication	5.6%
439	Vocal Cord Paralysis	5.6%
440	Nutrition Disorders	5.6%
441	Achlorhydria	5.6%
442	Osteoporosis	5.6%
443	Bone Demineralization, Pathologic	5.6%
444	Post-Traumatic Osteoporosis	5.6%
445	Celiac Disease	5.6%
446	Sprue, Tropical	5.6%
447	Steatorrhea	5.6%
448	Sprue	5.6%
449	Autoimmune Lymphoproliferative Syndrome	5.5%
450	Marfan Syndrome	5.5%
451	Glycogen Storage Disease Type I	5.5%
452	Glycogen Storage Disease Type V	5.5%
453	Cluster Headache	5.5%
454	Migraine with Aura	5.5%
455	Familial Hemiplegic Migraine	5.5%
456	Chronic Paroxysmal Hemicrania	5.5%
457	SUNCT Syndrome	5.5%
458	Paroxysmal Hemicrania	5.5%
459	Antley-Bixler Syndrome Phenotype	5.5%
460	Anencephaly	5.5%
461	Angioedemas, Hereditary	5.4%
462	Renal Osteodystrophy	5.4%
463	Renal rickets	5.4%
464	Variegate Porphyria	5.4%
465	Acute intermittent porphyria	5.4%
466	Porphyria Cutanea Tarda	5.4%
467	Choroid Plexus Papilloma	5.4%
468	Voice Disorders	5.4%
469	Voice Disturbance	5.4%
470	Renal Aminoacidurias	5.4%
471	Fanconi Syndrome	5.4%
472	Pseudohypoaldosteronism	5.4%
473	Liddle Syndrome	5.4%
474	Wiskott-Aldrich Syndrome	5.3%
475	HIV-Associated Lipodystrophy Syndrome	5.3%
476	Carotid Stenosis	5.3%
477	Intracranial Aneurysm	5.3%
478	Welander Distal Myopathy	5.3%
479	Intracranial Arteriosclerosis	5.2%
480	Cerebral Atherosclerosis	5.2%
481	Subarachnoid Hemorrhage	5.2%
482	Cerebral Arteriosclerosis	5.2%
483	Cerebral Hemorrhage	5.2%
484	Cerebral Thrombosis	5.2%
485	Intracranial Embolism	5.2%
486	Intracranial Thrombosis	5.2%
487	HIV Wasting Syndrome	5.2%
488	Friedreich Ataxia	5.2%
489	Neuroaspergillosis	5.1%
490	Brachial Plexus Neuritis	5.1%
491	Neuralgic Amyotrophy	5.1%
492	Cerebrospinal Fluid Otorrhea	5%
493	Cerebrospinal Fluid Rhinorrhea	5%
494	Neuritis, Autoimmune, Experimental	5%
495	Deformity	5%
496	Gait Ataxia	5%
497	Alcohol Withdrawal Seizures	5%
498	Ectodermal Dysplasia	4.9%
499	Gout	4.9%
500	Aplasia Cutis Congenita	4.9%
501	Kallmann Syndrome	4.9%
502	Glycosuria	4.9%
503	Familial Mediterranean Fever	4.9%
504	Meningomyelocele	4.9%
505	Spina Bifida	4.9%
506	Acidosis, Lactic	4.9%
507	Calciphylaxis	4.9%
508	Hemosiderosis	4.9%
509	Ketosis	4.9%
510	Ketonuria	4.9%
511	Ketoacidosis	4.9%
512	Ketonemia	4.9%
513	Vascular calcification	4.9%
514	Coma, Post-Head Injury	4.8%
515	Reflex, Abnormal	4.7%
516	Hyporeflexia	4.7%
517	Hyperreflexia	4.7%
518	Hyperprolactinemia	4.7%
519	Subclavian Steal Syndrome	4.7%
520	Pick Disease of the Brain	4.7%
521	Pseudorabies	4.7%
522	Carotid Artery Thrombosis	4.7%
523	Hematoma, Subdural	4.6%
524	Hematoma, Epidural, Cranial	4.6%
525	Neuritis	4.6%
526	Polyneuritis	4.6%
527	Radiculitis	4.6%
528	Polyneuropathy	4.6%
529	Mononeuritis	4.6%
530	Mononeuropathies	4.6%
531	Brachial Plexus Neuropathies	4.6%
532	Radiculopathy	4.6%
533	Mononeuropathy Multiplex	4.6%
534	Nerve Root Compression	4.6%
535	Akathisia	4.5%
536	Restlessness	4.5%
537	Psychomotor Agitation	4.5%
538	Neurosyphilis	4.5%
539	Multiple Sclerosis, Chronic Progressive	4.4%
540	Multiple Sclerosis, Relapsing-Remitting	4.4%
541	Optic Nerve Glioma	4.4%
542	Tarsal Tunnel Syndrome	4.4%
543	Cauda Equina Syndrome	4.4%
544	Fetal Diseases	4.4%
545	Necrobiosis Lipoidica Diabeticorum	4.4%
546	Polycystic Kidney Diseases	4.3%
547	Congenital nystagmus	4.3%
548	Sickle Cell Trait	4.3%
549	Meningocele	4.3%
550	Encephalocele	4.3%
551	Cystinuria	4.3%
552	Acidosis, Respiratory	4.2%
553	Adiposis Dolorosa	4.2%
554	Alkalosis, Respiratory	4.2%
555	Primary Ciliary Dyskinesia	4.2%
556	Acromegaly	4.2%
557	Insulin Resistance	4.2%
558	Osteoporosis, Postmenopausal	4.2%
559	Sinus Thrombosis, Intracranial	4.1%
560	Gait Apraxia	4%
561	Hypercholesterolemia	4%
562	Hyperlipoproteinemias	4%
563	Hypertriglyceridemia	4%
564	Lyme Neuroborreliosis	4%
565	Retinal Dysplasia	4%
566	Myositis	4%
567	Optic Atrophy	4%
568	Optic Neuritis	4%
569	Papilledema	4%
570	Strabismus	4%
571	Tolosa-Hunt Syndrome	4%
572	Isaacs syndrome	4%
573	Arsenic Poisoning	4%
574	Myotonic Disorders	4%
575	Aniridia	4%
576	Diabetic Neuropathies	4%
577	Facial Injuries	4%
578	Facial Neuralgia	4%
579	Diabetic Amyotrophy	4%
580	Diabetic Autonomic Neuropathy	4%
581	Sleep Talking	4%
582	Manganese Poisoning	4%
583	Sleep Disorders, Intrinsic	4%
584	Orthostatic intolerance	4%
585	Anosmia	3.9%
586	Ataxia	3.9%
587	Athetosis	3.9%
588	Catalepsy	3.9%
589	Dystonia	3.9%
590	Hemiplegia	3.9%
591	Locked-In Syndrome	3.9%
592	Meningeal Neoplasms	3.9%
593	Muscle Hypertonia	3.9%
594	Muscle hypotonia	3.9%
595	Myoclonus	3.9%
596	Myotonia	3.9%
597	Neuralgia	3.9%
598	Paraplegia	3.9%
599	Pseudobulbar Palsy	3.9%
600	Quadriplegia	3.9%
601	Spasm	3.9%
602	Spastic Paraplegia	3.9%
603	Status Epilepticus	3.9%
604	Taste Disorders	3.9%
605	Tremor	3.9%
606	Monoplegia	3.9%
607	Hypokinesia	3.9%
608	Paraparesis	3.9%
609	Bradykinesia	3.9%
610	Waxy flexibility	3.9%
611	Action Tremor	3.9%
612	Resting Tremor	3.9%
613	Dysosmia	3.9%
614	Quadriparesis	3.9%
615	Mercury Poisoning, Nervous System	3.9%
616	Olfaction Disorders	3.9%
617	Myokymia	3.9%
618	Lead Poisoning, Nervous System	3.9%
619	Vestibular Neuronitis	3.9%
620	Somatosensory Disorders	3.9%
621	Neuropathic pain	3.9%
622	Hyperkinesia	3.9%
623	Intention tremor	3.9%
624	Acoustic Neuroma	3.9%
625	Epidermolysis Bullosa	3.9%
626	Arthritis, Gouty	3.9%
627	Carpal Tunnel Syndrome	3.8%
628	neurofibroma	3.8%
629	Sciatica	3.8%
630	Waterhouse-Friderichsen Syndrome	3.7%
631	Hematoma, Subdural, Intracranial	3.7%
632	Hematoma, Subdural, Chronic	3.7%
633	Hematoma, Subdural, Acute	3.7%
634	Gestational Diabetes	3.7%
635	Latent Autoimmune Diabetes in Adults	3.7%
636	Cutis Laxa	3.7%
637	Diabetes Mellitus, Experimental	3.7%
638	Retinitis Pigmentosa	3.7%
639	Pigmentary retinopathy	3.7%
640	Porokeratosis	3.7%
641	Keratoderma, Palmoplantar	3.7%
642	Chronic granulomatous disease	3.7%
643	Malaria, Cerebral	3.7%
644	Nephrocalcinosis	3.7%
645	Neurocysticercosis	3.6%
646	Hand-Arm Vibration Syndrome	3.6%
647	Acute Chest Syndrome	3.6%
648	Cavernous Sinus Thrombosis	3.5%
649	Sagittal Sinus Thrombosis	3.5%
650	Vision Disorders	3.5%
651	Metamorphopsia	3.5%
652	Visual Impairment	3.5%
653	Fibromyalgia	3.5%
654	Optic Neuropathy, Ischemic	3.5%
655	Anterior Ischemic Optic Neuropathy	3.5%
656	Medial Tibial Stress Syndrome	3.5%
657	Facial Hemiatrophy	3.5%
658	Melkersson-Rosenthal Syndrome	3.5%
659	Anisocoria	3.5%
660	Confusion	3.5%
661	Facial paralysis	3.5%
662	Lethargy	3.5%
663	Memory Disorders	3.5%
664	Muscle Cramp	3.5%
665	Perceptual Disorders	3.5%
666	Psychomotor Disorders	3.5%
667	Tonic Pupil	3.5%
668	Eosinophilia-Myalgia Syndrome	3.5%
669	Anhedonia	3.5%
670	Disorientation	3.5%
671	Facial Paresis	3.5%
672	Memory Loss	3.5%
673	Hemisensory Neglect	3.5%
674	Dysacusis	3.5%
675	Sleep Bruxism	3.5%
676	Muscular Atrophy	3.5%
677	Respiratory Paralysis	3.5%
678	Meconium Aspiration Syndrome	3.4%
679	Prolactinoma	3.3%
680	Growth Hormone-Secreting Pituitary Adenoma	3.3%
681	Pseudoxanthoma Elasticum	3.3%
682	Child Nutrition Disorders	3.3%
683	Hypervitaminosis A	3.3%
684	Infant Nutrition Disorders	3.3%
685	Malnutrition	3.3%
686	Peutz-Jeghers Syndrome	3.3%
687	Thrombasthenia	3.3%
688	Primary amyloidosis	3.3%
689	Antithrombin III Deficiency	3.3%
690	Protein C Deficiency	3.3%
691	Afibrinogenemia	3.3%
692	Factor VII Deficiency	3.3%
693	Factor X Deficiency	3.3%
694	Factor XII Deficiency	3.3%
695	Hemophilia A	3.3%
696	Activated Protein C Resistance	3.3%
697	Factor II deficiency	3.3%
698	Factor VIII Deficiency	3.3%
699	Factor V deficiency	3.3%
700	Factor XI Deficiency	3.3%
701	Hypoprothrombinemias	3.3%
702	Microcephaly	3.2%
703	Macrocephaly	3.2%
704	Anemia, Diamond-Blackfan	3.2%
705	Dermal Sinus	3.2%
706	Spina Bifida Cystica	3.2%
707	Spina Bifida Occulta	3.2%
708	Lissencephaly	3.2%
709	Polymicrogyria	3.2%
710	Pachygyria	3.2%
711	Schizencephaly	3.2%
712	Periventricular Nodular Heterotopia	3.2%
713	Cubital Tunnel Syndrome	3.2%
714	Nelson Syndrome	3.2%
715	Consciousness Disorders	3.1%
716	Mental Retardation	3.1%
717	Muscle Weakness	3.1%
718	Depressed Level of Consciousness	3.1%
719	Mental deficiency	3.1%
720	Intellectual Disability	3.1%
721	Bell Palsy	3.1%
722	Catatonia	3.1%
723	Herpes Zoster Oticus	3.1%
724	Aphonia	3.1%
725	Sleep Deprivation	3.1%
726	Dysphonia	3.1%
727	POEMS Syndrome	3.1%
728	Porencephaly	3%
729	Multiple Endocrine Neoplasia	3%
730	Congenital Hypothyroidism	3%
731	Sciatic Neuropathy	3%
732	Ulnar Neuropathies	3%
733	Lesion of Sciatic Nerve	3%
734	Ulnar Neuritis	3%
735	Radial nerve compression	3%
736	Radial Tunnel Syndrome	3%
737	Peroneal Neuropathies	3%
738	Radial Neuropathy	3%
739	Median Neuropathy	3%
740	Sciatic Nerve Palsy	3%
741	Femoral Neuropathy	3%
742	Tibial Neuropathy	3%
743	Ulnar Nerve Palsy	3%
744	Postural Orthostatic Tachycardia Syndrome	3%
745	Radial nerve palsy	3%
746	Dermatitis, Atopic	3%
747	Xeroderma	2.9%
748	Polycystic Kidney, Autosomal Dominant	2.9%
749	Basal Cell Nevus Syndrome	2.8%
750	Hyperkeratosis, Epidermolytic	2.8%
751	Myalgia	2.8%
752	Abdominal Cramps	2.7%
753	Abnormalities, Drug-Induced	2.7%
754	Amniotic Band Syndrome	2.7%
755	Asphyxia Neonatorum	2.7%
756	Infant, Premature, Diseases	2.7%
757	Situs Inversus	2.7%
758	Infantile Colic	2.7%
759	Behcet Syndrome	2.7%
760	CREST Syndrome	2.6%
761	Thoracic Outlet Syndrome	2.6%
762	Alexia	2.6%
763	Dyslexia	2.6%
764	Esotropia	2.6%
765	Exotropia	2.6%
766	Hypotension, Orthostatic	2.6%
767	Sleep Apnea Syndromes	2.6%
768	Polymyositis	2.6%
769	Post-Exercise Hypotension	2.6%
770	Hoarseness	2.5%
771	Disorders of Excessive Somnolence	2.5%
772	Sleep Initiation and Maintenance Disorders	2.5%
773	Night Terrors	2.5%
774	Somnambulism	2.5%
775	Trigeminal Nerve Disorder	2.5%
776	Transient Insomnia	2.5%
777	Sleep Paralysis	2.5%
778	Chronic Insomnia	2.5%
779	REM Sleep Behavior Disorder	2.5%
780	Hypersomnia	2.5%
781	Dysgeusia	2.5%
782	Formication	2.5%
783	Hyperalgesia	2.5%
784	Hyperesthesia	2.5%
785	Hypesthesia	2.5%
786	Language Disorders	2.5%
787	Numbness	2.5%
788	Paresthesia	2.5%
789	Paraparesis, Spastic	2.5%
790	Trismus	2.5%
791	Epilepsia Partialis Continua	2.5%
792	Hypogeusia	2.5%
793	Meningeal Carcinomatosis	2.5%
794	Brown-Sequard Syndrome	2.5%
795	Lockjaw	2.5%
796	Allodynia	2.5%
797	Lead Poisoning, Nervous System, Childhood	2.5%
798	Lead Poisoning, Nervous System, Adult	2.5%
799	Ageusia	2.5%
800	Alcohol Withdrawal Delirium	2.5%
801	Papillon-Lefevre Disease	2.4%
802	Eye Abnormalities	2.4%
803	Cardiovascular Abnormalities	2.4%
804	Skin Abnormalities	2.4%
805	Lymphatic Abnormalities	2.4%
806	Congenital Microtia	2.4%
807	Anemia, Neonatal	2.4%
808	Persistent Fetal Circulation Syndrome	2.4%
809	Congenital diaphragmatic hernia	2.3%
810	Umbilical hernia	2.3%
811	Neurofibrosarcoma	2.3%
812	Eye Injuries	2.3%
813	Orbital Myositis	2.3%
814	Nephroblastoma	2.3%
815	Diplopia	2.2%
816	Muscle Rigidity	2.2%
817	Muscle Spasticity	2.2%
818	Scotoma	2.2%
819	Photophobia	2.2%
820	Cogwheel Rigidity	2.2%
821	Hemifacial Spasm	2.2%
822	Amaurosis	2.2%
823	Blindness	2.2%
824	Nuchal Rigidity	2.2%
825	Pyomyositis	2.2%
826	Agnosia	2.2%
827	Apraxias	2.2%
828	Hallucinations	2.2%
829	Hemianopsia	2.2%
830	Hyperacusis	2.2%
831	Tinnitus	2.2%
832	Visual Agnosia	2.2%
833	Anosognosia	2.2%
834	Wernicke-Korsakoff Syndrome	2.2%
835	Phonophobia	2.2%
836	Hearing Loss	2.2%
837	Sarcopenia	2.2%
838	Deficiency Diseases	2.2%
839	Starvation	2.2%
840	Refeeding Syndrome	2.2%
841	Polyradiculopathy	2.2%
842	Urogenital Abnormalities	2.1%
843	Neonatal Abstinence Syndrome	2.1%
844	Adenomatous Polyposis Coli	2.1%
845	Fetal Growth Retardation	2.1%
846	Fetal Hypoxia	2.1%
847	Fetal Alcohol Spectrum Disorders	2.1%
848	Hydrops Fetalis	2%
849	Syphilis, Congenital	2%
850	Klinefelter Syndrome	2%
851	Amnesia	2%
852	Delirium	2%
853	Dissociative Amnesia	2%
854	Color blindness	2%
855	Global Amnesia	2%
856	Meningioma	2%
857	Turner Syndrome	2%
858	Multiple Endocrine Neoplasia Type 1	2%
859	Sleep Apnea, Obstructive	1.8%
860	Sleep Apnea, Central	1.8%
861	Narcolepsy	1.8%
862	Trigeminal Neuralgia	1.8%
863	Kleine-Levin Syndrome	1.8%
864	Agraphia	1.8%
865	Anomia	1.8%
866	Cluttering	1.8%
867	Language Development Disorders	1.8%
868	Speech Disorders	1.8%
869	Syncope	1.8%
870	Stupor	1.8%
871	Dysgraphia	1.8%
872	Presyncope	1.8%
873	Dyslalia	1.8%
874	Chorioamnionitis	1.8%
875	Maxillofacial Abnormalities	1.8%
876	Dextrocardia	1.8%
877	Phantom pain	1.8%
878	Phantom Limb Pain	1.8%
879	Abnormalities, Radiation-Induced	1.6%
880	Eye Burns	1.6%
881	Prune Belly Syndrome	1.6%
882	Twins, Conjoined	1.6%
883	Waardenburg Syndrome	1.6%
884	Kwashiorkor	1.6%
885	Magnesium Deficiency	1.6%
886	Potassium Deficiency	1.6%
887	Protein Deficiency	1.6%
888	Avitaminosis	1.6%
889	Amaurosis Fugax	1.6%
890	Blindness, Cortical	1.6%
891	Dyscalculia	1.6%
892	Deafness	1.6%
893	Hearing Loss, Sudden	1.6%
894	Gerstmann Syndrome	1.6%
895	Hearing Loss, Bilateral	1.6%
896	Hearing Loss, High-Frequency	1.6%
897	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
898	Prosopagnosia	1.6%
899	Apraxia, Ideomotor	1.6%
900	Charles Bonnet Syndrome	1.6%
901	Hearing Loss, Unilateral	1.6%
902	Complete Hearing Loss	1.6%
903	Alien Hand Syndrome	1.6%
904	Deaf Mutism	1.6%
905	Scimitar Syndrome	1.5%
906	Cataplexy	1.5%
907	Aphasia	1.5%
908	Articulation Disorders	1.5%
909	Echolalia	1.5%
910	Stuttering	1.5%
911	Dysphasia	1.5%
912	Ophthalmia Neonatorum	1.5%
913	Dermatomyositis	1.5%
914	Corneal Scar	1.5%
915	Retrograde amnesia	1.4%
916	Amnesia, Anterograde	1.4%
917	Obesity	1.4%
918	Denys-Drash Syndrome	1.4%
919	Anophthalmos	1.4%
920	Anus, Imperforate	1.4%
921	Microphthalmos	1.4%
922	Paralysis, Obstetric	1.4%
923	Retinopathy of Prematurity	1.4%
924	Limb Deformities, Congenital	1.4%
925	Craniofacial Abnormalities	1.4%
926	Anorectal Malformations	1.4%
927	Bronchopulmonary Dysplasia	1.4%
928	Ascorbic Acid Deficiency	1.3%
929	Vitamin A Deficiency	1.3%
930	Vitamin D Deficiency	1.3%
931	Vitamin E Deficiency	1.3%
932	Marasmus	1.3%
933	Mutism	1.3%
934	Selective Mutism	1.3%
935	Dysarthria	1.3%
936	Craniosynostosis	1.3%
937	Syndactyly	1.3%
938	Brachycephaly	1.3%
939	Acrocephalosyndactylia	1.3%
940	Blepharophimosis	1.2%
941	Laryngostenosis	1.2%
942	Mouth Abnormalities	1.2%
943	Respiratory Distress Syndrome, Newborn	1.2%
944	Esophageal Atresia	1.2%
945	Intestinal Atresia	1.2%
946	Horseshoe Kidney	1.2%
947	Pectus excavatum	1.2%
948	Klippel-Feil Syndrome	1.2%
949	Gastroschisis	1.2%
950	Synostosis	1.2%
951	Acrodermatitis	1.2%
952	Lymphangiectasis, Intestinal	1.2%
953	Gianotti-Crosti Syndrome	1.2%
954	Folic Acid Deficiency	1.2%
955	Pellagra	1.2%
956	Thiamine Deficiency	1.2%
957	Vitamin B 12 Deficiency	1.2%
958	Vitamin B 6 Deficiency	1.2%
959	Pyridoxine Deficiency	1.2%
960	Obesity, Abdominal	1.2%
961	Noonan Syndrome	1.2%
962	Corneal Perforation	1.2%
963	Alexia, Pure	1.2%
964	Beriberi	1.1%
965	Arthrogryposis	1.1%
966	Choanal Atresia	1.1%
967	Tracheobronchomegaly	1.1%
968	Laryngocele	1.1%
969	Choledochal Cyst	1.1%
970	Hermaphroditism	1.1%
971	Disorders of Sex Development	1.1%
972	Cleft Palate	1.1%
973	Cryptorchidism	1.1%
974	Hypospadias	1.1%
975	Pediatric Obesity	1.1%
976	Jaw Abnormalities	1%
977	Vitamin K Deficiency	1%
978	Laryngomalacia	1%
979	Pectus carinatum	1%
980	Bladder Exstrophy	1%
981	Epispadias	1%
982	Multicystic Dysplastic Kidney	1%
983	Anemia, Pernicious	1%
984	Poland Syndrome	1%
985	Amelia	0.9%
986	Arachnodactyly	0.9%
987	Ectopia Cordis	0.9%
988	Ectromelia	0.9%
989	Hemimelia	0.9%
990	Phocomelia	0.9%
991	Sirenomelia	0.9%
992	Polydactyly	0.9%
993	Brachydactyly	0.9%
994	Plagiocephaly	0.9%
995	Lower Extremity Deformities, Congenital	0.9%
996	Upper Extremity Deformities, Congenital	0.9%
997	Single umbilical artery	0.9%
998	Scurvy	0.9%
999	Aortic coarctation	0.8%
1000	Cor Triatriatum	0.8%
1001	Coronary Vessel Anomalies	0.8%
1002	Dental Enamel Hypoplasia	0.8%
1003	Patent ductus arteriosus	0.8%
1004	Ebstein Anomaly	0.8%
1005	Heart Septal Defects	0.8%
1006	Hyaline Membrane Disease	0.8%
1007	Hypodontia	0.8%
1008	Macrostomia	0.8%
1009	Microstomia	0.8%
1010	Tetralogy of Fallot	0.8%
1011	Transposition of Great Vessels	0.8%
1012	Hypoplastic Left Heart Syndrome	0.8%
1013	May-Thurner Syndrome	0.8%
1014	Craniofacial Dysostosis	0.8%
1015	Micrognathism	0.8%
1016	Pierre Robin Syndrome	0.8%
1017	Wolff-Parkinson-White Syndrome	0.8%
1018	Retrognathia	0.7%
1019	Hyperandrogenism	0.7%
1020	Long QT Syndrome	0.7%
1021	Platybasia	0.7%
1022	Tricuspid Atresia	0.7%
1023	Arrhythmogenic Right Ventricular Dysplasia	0.7%
1024	Gonadal Dysgenesis	0.7%
1025	Bronchomalacia	0.7%
1026	Adrenogenital Syndrome	0.7%
1027	Tracheomalacia	0.7%
1028	Ovotesticular Disorders of Sex Development	0.7%
1029	Prognathism	0.7%
1030	Aortopulmonary Septal Defect	0.6%
1031	Double Outlet Right Ventricle	0.6%
1032	Endocardial Cushion Defects	0.6%
1033	Myocardial bridging	0.6%
1034	Aorticopulmonary Septal Defect	0.6%
1035	Mandibulofacial Dysostosis	0.5%
1036	Romano-Ward Syndrome	0.5%
1037	Truncus Arteriosus, Persistent	0.5%
1038	Goldenhar Syndrome	0.5%
1039	Talipes	0.5%
1040	Arteriovenous fistula	0.4%
1041	Congenital clubfoot	0.4%
1042	Vertical Talus	0.4%

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