MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lymphatic Abnormalities

(UMLS:C0398368)

Definition:: Congenital or acquired structural abnormalities of the lymphatic system (LYMPHOID TISSUE) including the lymph vessels.
UMLS ID:: C0398368
MeSH ID:: D044148

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.451

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.482

Synonym(s)

Lymphatic Abnormalities

Lymphatic malformation

Lymphatics--Abnormalities

disorder of lymphatic vessel lymphatic malformation

lymphatic abnormality

lymphatic malformation

lymphatic malformations

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Polychlorinated Dibenzodioxins		30499018	CTD
2	Sulfasalazine		12587019	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Beckwith-Wiedemann Syndrome	28.8%
2	Wolf-Hirschhorn Syndrome	28.8%
3	Abnormalities, Drug-Induced	28.6%
4	Adenitis	28.6%
5	Histiocytosis	28.6%
6	Lymphadenitis	28.6%
7	Lymphangitis	28.6%
8	Lymphedema	28.6%
9	Situs Inversus	28.6%
10	Splenic Diseases	28.6%
11	Thymus Hyperplasia	28.6%
12	Pseudolymphoma	28.6%
13	Lymphadenopathy	28.6%
14	Holoprosencephaly	26.9%
15	Smith-Magenis syndrome	24.1%
16	Cri-du-Chat Syndrome	23.7%
17	Down Syndrome	23.7%
18	Trisomy 21	23.7%
19	Anencephaly	22.4%
20	Eye Abnormalities	22.2%
21	Cardiovascular Abnormalities	22.2%
22	Aicardi's syndrome	21.9%
23	Lymphocele	21.4%
24	Lymphoproliferative Disorders	21.4%
25	Skin Abnormalities	21.4%
26	Congenital Microtia	21.4%
27	Rubinstein-Taybi Syndrome	21.2%
28	Thymus Neoplasms	21.1%
29	Elephantiasis	20.9%
30	Hypersplenism	20.9%
31	Prune Belly Syndrome	20.9%
32	Sarcoidosis	20.9%
33	Twins, Conjoined	20.9%
34	Elephantiasis Nostras Verrucosa	20.9%
35	Waardenburg Syndrome	20.9%
36	Congenital diaphragmatic hernia	20.9%
37	Ectodermal Dysplasia	20.4%
38	Aplasia Cutis Congenita	20.4%
39	Prader-Willi Syndrome	20.2%
40	Maxillofacial Abnormalities	18.9%
41	Dural Arteriovenous Fistula	18.9%
42	Dextrocardia	18.6%
43	CHARGE Syndrome	18.1%
44	Urogenital Abnormalities	17.6%
45	Kartagener Syndrome	17.6%
46	Lymphohistiocytosis, Hemophagocytic	17.2%
47	Erdheim-Chester Disease	17.2%
48	Agammaglobulinemia	16.7%
49	Mucocutaneous Lymph Node Syndrome	16.7%
50	Microcephaly	15.9%
51	Macrocephaly	15.9%
52	Anophthalmos	15.8%
53	Anus, Imperforate	15.8%
54	Granuloma	15.8%
55	Histiocytic Disorders, Malignant	15.8%
56	Hydranencephaly	15.8%
57	Microphthalmos	15.8%
58	Neural Tube Defects	15.8%
59	Splenic Infarction	15.8%
60	Splenic Neoplasms	15.8%
61	Tethered Cord Syndrome	15.8%
62	Iniencephaly	15.8%
63	Craniorachischisis	15.8%
64	Limb Deformities, Congenital	15.8%
65	Exencephaly	15.8%
66	Septo-Optic Dysplasia	15.8%
67	Craniofacial Abnormalities	15.8%
68	Cortical Dysplasia	15.8%
69	Malformations of Cortical Development	15.8%
70	Anorectal Malformations	15.8%
71	Heavy Chain Disease	15.6%
72	Marfan Syndrome	15.6%
73	Bloom Syndrome	15.5%
74	Histiocytosis, Langerhans-Cell	15.5%
75	Tumor Lysis Syndrome	15.5%
76	Nail-Patella Syndrome	15.1%
77	Autoimmune Lymphoproliferative Syndrome	15.1%
78	Genetic Diseases, Inborn	15%
79	Xeroderma	14.9%
80	Mobius Syndrome	14.9%
81	Porencephaly	14.9%
82	Classical Lissencephalies and Subcortical Band Heterotopias	14.7%
83	Acrocephalosyndactylia	14.6%
84	Sezary Syndrome	14.4%
85	Craniosynostosis	14.3%
86	Syndactyly	14.3%
87	Brachycephaly	14.3%
88	Scimitar Syndrome	14.3%
89	Fragile X Syndrome	14.2%
90	Alstrom Syndrome	13.8%
91	Infectious Mononucleosis	13.6%
92	Polycystic Kidney Diseases	13.4%
93	Williams Syndrome	13.4%
94	Turner Syndrome	13%
95	Thrombasthenia	13%
96	Antithrombin III Deficiency	13%
97	Protein C Deficiency	13%
98	POEMS Syndrome	12.9%
99	Amelia	12.8%
100	Arachnodactyly	12.8%
101	Ectopia Cordis	12.8%
102	Ectromelia	12.8%
103	Hemimelia	12.8%
104	Malignant histiocytosis	12.8%
105	Meningomyelocele	12.8%
106	Phocomelia	12.8%
107	Sarcoidosis, Pulmonary	12.8%
108	Sirenomelia	12.8%
109	Spina Bifida	12.8%
110	Polydactyly	12.8%
111	Brachydactyly	12.8%
112	Plagiocephaly	12.8%
113	Histiocytic sarcoma	12.8%
114	Lower Extremity Deformities, Congenital	12.8%
115	Upper Extremity Deformities, Congenital	12.8%
116	Single umbilical artery	12.8%
117	Primary Ciliary Dyskinesia	12.7%
118	Noonan Syndrome	12.7%
119	Poland Syndrome	12.7%
120	Anemia, Sickle Cell	12.7%
121	Blepharophimosis	12.7%
122	Laryngostenosis	12.7%
123	Mouth Abnormalities	12.7%
124	Splenic Rupture	12.7%
125	Thalassemia	12.7%
126	Cockayne Syndrome	12.7%
127	Esophageal Atresia	12.5%
128	Intestinal Atresia	12.5%
129	Lymphoma	12.5%
130	Horseshoe Kidney	12.5%
131	Pectus excavatum	12.5%
132	Klippel-Feil Syndrome	12.4%
133	Gastroschisis	12.4%
134	Synostosis	12.4%
135	Cleft Palate	12.4%
136	Afibrinogenemia	12.4%
137	Factor VII Deficiency	12.4%
138	Factor X Deficiency	12.4%
139	Factor XII Deficiency	12.4%
140	Hemophilia A	12.4%
141	Activated Protein C Resistance	12.4%
142	Factor II deficiency	12.4%
143	Factor VIII Deficiency	12.4%
144	Factor V deficiency	12.4%
145	Factor XI Deficiency	12.4%
146	Hypoprothrombinemias	12.4%
147	Acrodermatitis	12.3%
148	Disseminated Intravascular Coagulation	12.3%
149	Lymphangiectasis, Intestinal	12.3%
150	Protein S Deficiency	12.3%
151	Gianotti-Crosti Syndrome	12.3%
152	Anemia, Neonatal	12.3%
153	Pelger-Huet Anomaly	12.3%
154	Thymoma	12.2%
155	Jaw Abnormalities	12.1%
156	Thrombocythemia, Essential	12%
157	Retinal Dysplasia	12%
158	Aniridia	11.9%
159	Waldenstrom Macroglobulinemia	11.8%
160	Epidermolysis Bullosa	11.7%
161	Abnormalities, Radiation-Induced	11.6%
162	Smith-Lemli-Opitz Syndrome	11.6%
163	Wiskott-Aldrich Syndrome	11.5%
164	Klinefelter Syndrome	11.5%
165	Ichthyosis, X-Linked	11.5%
166	Dermal Sinus	11.4%
167	Spina Bifida Cystica	11.4%
168	Spina Bifida Occulta	11.4%
169	Lissencephaly	11.4%
170	Polymicrogyria	11.4%
171	Pachygyria	11.4%
172	Schizencephaly	11.4%
173	Periventricular Nodular Heterotopia	11.4%
174	Fetal Diseases	11.1%
175	Anemia, Diamond-Blackfan	11.1%
176	Polycystic Kidney, Autosomal Dominant	11%
177	Pseudoxanthoma Elasticum	10.9%
178	Micrognathism	10.9%
179	Pierre Robin Syndrome	10.9%
180	Sickle Cell Trait	10.7%
181	Arthrogryposis	10.6%
182	Choanal Atresia	10.6%
183	Tracheobronchomegaly	10.6%
184	Laryngocele	10.6%
185	Choledochal Cyst	10.5%
186	Hermaphroditism	10.5%
187	Disorders of Sex Development	10.5%
188	Cryptorchidism	10.3%
189	Hypospadias	10.3%
190	Central Nervous System Cysts	10.3%
191	Dandy-Walker Syndrome	10.2%
192	Aortic coarctation	10.2%
193	Cor Triatriatum	10.2%
194	Coronary Vessel Anomalies	10.2%
195	Dental Enamel Hypoplasia	10.2%
196	Patent ductus arteriosus	10.2%
197	Ebstein Anomaly	10.2%
198	Heart Septal Defects	10.2%
199	Hypodontia	10.2%
200	Macrostomia	10.2%
201	Meningocele	10.2%
202	Microstomia	10.2%
203	Tetralogy of Fallot	10.2%
204	Transposition of Great Vessels	10.2%
205	Hypoplastic Left Heart Syndrome	10.2%
206	Splenosis	10.2%
207	May-Thurner Syndrome	10.2%
208	Encephalocele	10.2%
209	Craniofacial Dysostosis	10.1%
210	Hodgkin Disease	10.1%
211	Lymphoma, Non-Hodgkin	10.1%
212	Leukemia, T-Cell	10.1%
213	Wolff-Parkinson-White Syndrome	10.1%
214	Leukemia, B-Cell	10.1%
215	Eosinophilic Granuloma	9.7%
216	Retrognathia	9.7%
217	Hyperkeratosis, Epidermolytic	9.7%
218	Abdominal Cramps	9.5%
219	Amniotic Band Syndrome	9.5%
220	Anemia	9.5%
221	Asphyxia Neonatorum	9.5%
222	Blood Coagulation Disorders	9.5%
223	Blood Platelet Disorders	9.5%
224	Bone Marrow Diseases	9.5%
225	Cystic Fibrosis	9.5%
226	Hemorrhagic Disorders	9.5%
227	Infant, Premature, Diseases	9.5%
228	Leukocyte Disorders	9.5%
229	Methemoglobinemia	9.5%
230	Pancytopenia	9.5%
231	Polycythemia	9.5%
232	Sulfhemoglobinemia	9.5%
233	Infantile Colic	9.5%
234	Thrombophilia	9.5%
235	Erythrocytosis	9.5%
236	Charcot-Marie-Tooth Disease	9.5%
237	Antley-Bixler Syndrome Phenotype	9.5%
238	Sjogren-Larsson Syndrome	9.5%
239	Thrombocytosis	9.4%
240	Aortopulmonary Septal Defect	9%
241	Double Outlet Right Ventricle	9%
242	Endocardial Cushion Defects	9%
243	Myocardial bridging	9%
244	Aorticopulmonary Septal Defect	9%
245	Lymphoma, Follicular	9%
246	T-Cell Lymphoma	9%
247	Laryngomalacia	9%
248	Mantle cell lymphoma	9%
249	Kallmann Syndrome	9%
250	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	9%
251	Leukemia, Large Granular Lymphocytic	9%
252	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	9%
253	Pectus carinatum	8.9%
254	Hyperandrogenism	8.8%
255	Bladder Exstrophy	8.8%
256	Epispadias	8.8%
257	Multicystic Dysplastic Kidney	8.7%
258	Prognathism	8.7%
259	Hemoglobinuria, Paroxysmal	8.5%
260	Leukemoid Reaction	8.5%
261	Long QT Syndrome	8.5%
262	Platybasia	8.5%
263	Tricuspid Atresia	8.5%
264	Arrhythmogenic Right Ventricular Dysplasia	8.5%
265	Truncus Arteriosus, Persistent	8.5%
266	Lymphoma, T-Cell, Cutaneous	8.4%
267	Lymphoma, AIDS-Related	8.4%
268	Goldenhar Syndrome	8.4%
269	Enteropathy-Associated T-Cell Lymphoma	8.4%
270	Primary Effusion Lymphoma	8.4%
271	Gonadal Dysgenesis	8.4%
272	Bronchomalacia	8.4%
273	Adrenogenital Syndrome	8.4%
274	Composite Lymphoma	8.4%
275	Tracheomalacia	8.4%
276	Ovotesticular Disorders of Sex Development	8.4%
277	Fanconi Anemia	8.4%
278	Polycythemia Vera	8.3%
279	Lymphangioleiomyomatosis	8.3%
280	Bone Marrow Neoplasms	8.2%
281	Mycosis Fungoides	8.2%
282	Lymphomatoid Papulosis	8.2%
283	Plasmablastic lymphoma	8.2%
284	Xeroderma Pigmentosum	8.2%
285	Vitamin K Deficiency	8.1%
286	Acute Chest Syndrome	8.1%
287	Meconium Aspiration Syndrome	8%
288	Tuberous Sclerosis	8%
289	Hydrops Fetalis	7.8%
290	Zellweger Syndrome	7.7%
291	Refsum Disease	7.6%
292	Mandibulofacial Dysostosis	7.5%
293	Chronic granulomatous disease	7.5%
294	Romano-Ward Syndrome	7.5%
295	Neoplastic Syndromes, Hereditary	7.4%
296	Transfusion Reaction	7.4%
297	Hypotensive Transfusion Reaction	7.4%
298	Basal Cell Nevus Syndrome	7.3%
299	Pregnancy Complications, Hematologic	7.1%
300	Hematologic Neoplasms	7.1%
301	Lymphomatoid Granulomatosis	7.1%
302	Talipes	7.1%
303	Multiple Epiphyseal Dysplasia	7%
304	Osteochondrodysplasias	7%
305	Persistent Fetal Circulation Syndrome	7%
306	Werner Syndrome	7%
307	Myasthenic Syndromes, Congenital	7%
308	Anemia, Hemolytic	7%
309	Anemia, Macrocytic	7%
310	Eosinophilia	7%
311	Hypoproteinemia	7%
312	Leukopenia	7%
313	Familial Mediterranean Fever	7%
314	Thrombocytopenia	7%
315	Leukostasis	7%
316	MYELODYSPLASTIC SYNDROME	7%
317	Purpura, Thrombotic Thrombocytopenic	6.9%
318	Umbilical hernia	6.9%
319	Niemann-Pick Disease, Type C	6.9%
320	Congenital clubfoot	6.8%
321	Vertical Talus	6.8%
322	Muscular Dystrophy, Duchenne	6.7%
323	Rett Syndrome	6.7%
324	Albinism	6.4%
325	Mucopolysaccharidosis II	6.2%
326	Burkitt Lymphoma	6%
327	Dwarfism	5.8%
328	Primary Myelofibrosis	5.7%
329	Agranulocytosis	5.7%
330	Anemia, Megaloblastic	5.7%
331	Lymphocytosis	5.7%
332	Myelofibrosis	5.7%
333	Myeloid Metaplasia	5.7%
334	Hypoalbuminemia	5.7%
335	Hypereosinophilic syndrome	5.7%
336	bone marrow fibrosis	5.7%
337	Thrombotic Microangiopathies	5.7%
338	Neonatal Abstinence Syndrome	5.7%
339	Cryoglobulinemia	5.6%
340	Monoclonal Gammopathy of Undetermined Significance	5.6%
341	Arteriovenous fistula	5.6%
342	Fetal Growth Retardation	5.6%
343	Muscular Dystrophy	5.5%
344	Osteogenesis Imperfecta	5.5%
345	Fetal Hypoxia	5.5%
346	Congenital nystagmus	5.5%
347	Fetal Alcohol Spectrum Disorders	5.5%
348	Autoimmune thrombocytopenia	5.5%
349	Immune thrombocytopenic purpura	5.5%
350	Menkes Kinky Hair Syndrome	5.5%
351	Toxoplasmosis, Congenital	5.5%
352	Syphilis, Congenital	5.4%
353	Leukocytosis	5.3%
354	Paralysis, Obstetric	5.3%
355	Paraproteinemias	5.3%
356	Retinopathy of Prematurity	5.3%
357	Pleocytosis	5.3%
358	Hemolytic-Uremic Syndrome	5.2%
359	Amino Acid Metabolism, Inborn Errors	5.2%
360	Carbohydrate Metabolism, Inborn Errors	5.2%
361	Metal Metabolism, Inborn Errors	5.2%
362	Progeria	5.2%
363	Lysosomal Storage Diseases	5.2%
364	Cytochrome-c Oxidase Deficiency	5.2%
365	Peroxisomal Disorders	5.2%
366	Neutropenia	5.1%
367	Bronchopulmonary Dysplasia	5.1%
368	Kernicterus	5.1%
369	Neuronal Ceroid-Lipofuscinoses	5%
370	Febrile Neutropenia	4.8%
371	Atypical Hemolytic Uremic Syndrome	4.8%
372	Purpura, Hyperglobulinemic	4.8%
373	Thrombocytopenic purpura	4.6%
374	Congenital Hyperinsulinism	4.6%
375	Chorioamnionitis	4.6%
376	Angioedemas, Hereditary	4.5%
377	Myotonic Dystrophy	4.5%
378	Adrenoleukodystrophy	4.4%
379	Glycogen storage disease type II	4.4%
380	Lymphopenia	4.3%
381	Fabry Disease	4.3%
382	Denys-Drash Syndrome	4.3%
383	Job Syndrome	4.3%
384	Alkaptonuria	4.2%
385	Glycogen Storage Disease	4.2%
386	Hypophosphatasia	4.2%
387	Leukemia, Myelomonocytic, Chronic	4.2%
388	Propionic acidemia	4.2%
389	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.2%
390	Dihydropyrimidine Dehydrogenase Deficiency	4.2%
391	Cystinosis	4.2%
392	Hypergammaglobulinemia	4.2%
393	Mucopolysaccharidosis III	4.2%
394	Respiratory Distress Syndrome, Newborn	4.2%
395	Multiple Myeloma	4.2%
396	Cutis Laxa	4.2%
397	Retinitis Pigmentosa	4.1%
398	Transfusion-Related Acute Lung Injury	4.1%
399	Pigmentary retinopathy	4.1%
400	Galactosemias	4.1%
401	Urea Cycle Disorders, Inborn	4.1%
402	Tyrosinemias	4.1%
403	Ecchymosis	4.1%
404	Petechiae	4.1%
405	Purpura	4.1%
406	Porokeratosis	4.1%
407	Keratoderma, Palmoplantar	4.1%
408	Hepatolenticular Degeneration	4.1%
409	Amyloid Neuropathies, Familial	4%
410	Welander Distal Myopathy	4%
411	Pulmonary Eosinophilia	3.9%
412	Eosinophilic Pneumonia	3.9%
413	Glycogen Storage Disease Type I	3.8%
414	Glycogen Storage Disease Type V	3.8%
415	Leukemia, Myeloid, Chronic-Phase	3.8%
416	Anemia, Pernicious	3.8%
417	Gaucher Disease	3.7%
418	Optic Atrophy, Hereditary, Leber	3.7%
419	Hyperphosphaturia	3.7%
420	Tay-Sachs Disease	3.5%
421	Homocystinuria	3.5%
422	Duane Retraction Syndrome	3.5%
423	Leigh Disease	3.5%
424	Canavan Disease	3.5%
425	Alexander Disease	3.5%
426	Eosinophilia-Myalgia Syndrome	3.4%
427	Porphyrias, Hepatic	3.4%
428	Hyaline Membrane Disease	3.4%
429	Shwartzman Phenomenon	3.4%
430	Peutz-Jeghers Syndrome	3.4%
431	Myotonia Congenita	3.4%
432	Brain Diseases, Metabolic, Inborn	3.4%
433	Hemangioma, Cavernous	3.4%
434	Dystonia Musculorum Deformans	3.4%
435	Leukomalacia, Periventricular	3.4%
436	Scurvy	3.4%
437	Hypolipoproteinemias	3.4%
438	Papillon-Lefevre Disease	3.4%
439	Purpura Fulminans	3.4%
440	Nesidioblastosis	3.4%
441	Hyperlipidemia, Familial Combined	3.3%
442	Hyperlipoproteinemia Type III	3.3%
443	Lafora Disease	3.3%
444	Unverricht-Lundborg Syndrome	3.3%
445	Ophthalmia Neonatorum	3.3%
446	Waterhouse-Friderichsen Syndrome	3.3%
447	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
448	Ataxia Telangiectasia	3%
449	Multiple Endocrine Neoplasia	3%
450	Hypoalphalipoproteinemias	3%
451	Congenital Hypothyroidism	2.9%
452	Dermatitis, Atopic	2.9%
453	Familial Periodic Paralysis	2.8%
454	Lactose Intolerance	2.8%
455	Variegate Porphyria	2.8%
456	Acute intermittent porphyria	2.8%
457	Porphyria Cutanea Tarda	2.8%
458	Hyperhomocysteinemia	2.8%
459	Renal Aminoacidurias	2.8%
460	Fanconi Syndrome	2.8%
461	Pseudohypoaldosteronism	2.8%
462	Liddle Syndrome	2.8%
463	Hyperlipoproteinemia Type IV	2.8%
464	Hyperlipoproteinemia Type V	2.8%
465	Behcet Syndrome	2.5%
466	Hypokalemic periodic paralysis	2.5%
467	Cystinuria	2.5%
468	Gout	2.4%
469	Multiple Endocrine Neoplasia Type 1	2.4%
470	Pseudohypoparathyroidism	2.4%
471	Friedreich Ataxia	2.4%
472	Renal tubular acidosis	2.4%
473	Huntington Disease	2.2%
474	Arthritis, Gouty	2.1%
475	Familial Hypophosphatemic Rickets	2.1%
476	Nephroblastoma	2%
477	Glycosuria, Renal	1.8%
478	Adenomatous Polyposis Coli	1.8%
479	MELAS Syndrome	1.5%

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