MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Periostitis

(UMLS:C0031111)

Definition:: Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)
UMLS ID:: C0031111
MeSH ID:: D010522

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.539.160.595

Classification 2:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.165.595

Synonym(s)

Periostitis

Periostalgia

Periosteitis fibrosa

Periostitis, NOS

periosteitis

periostitis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Voriconazole	FAERS: 73 Canada Vigilance: 5	Canada Vigilance SIDER US FAERS
2	Alendronate	FAERS: 28	US FAERS
3	Zoledronic Acid	FAERS: 3	OFFSIDES US FAERS
4	Diclofenac	FAERS: 2	US FAERS
5	Pamidronate	FAERS: 2	US FAERS
6	Pantoprazole	FAERS: 2	US FAERS
7	Alendronate	FAERS: 1	US FAERS
8	Alprostadil	FAERS: 1	US FAERS
9	Barium Sulfate	FAERS: 1	US FAERS
10	Dactinomycin	FAERS: 1	US FAERS
11	Etidronic Acid	FAERS: 1	US FAERS
12	Fulvestrant	FAERS: 1	US FAERS
13	Isotretinoin	FAERS: 1	US FAERS
14	Ruxolitinib phosphate	FAERS: 1	US FAERS
15	Tenofovir	FAERS: 1	OFFSIDES US FAERS
16	Teriparatide	FAERS: 1	US FAERS
17	Alprazolam		OFFSIDES
18	Beclomethasone		OFFSIDES
19	Capecitabine		OFFSIDES
20	Caspofungin		OFFSIDES
21	Cortisone		OFFSIDES
22	Darunavir		OFFSIDES
23	Fluorouracil		OFFSIDES
24	Goserelin		OFFSIDES
25	Letrozole		OFFSIDES
26	Lorazepam		OFFSIDES
27	Pamidronate		OFFSIDES
28	Penicillins		SIDER
29	Tamoxifen		OFFSIDES
30	Tenofovir		OFFSIDES
31	Venlafaxine Hydrochloride		OFFSIDES
32	alfacalcidol		OFFSIDES
33	benzathine		SIDER
34	doxifluridine		OFFSIDES
35	etravirine		OFFSIDES
36	exemestane		OFFSIDES
37	pitavastatin		OFFSIDES
38	temsirolimus		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Osteomyelitis	46.7%
2	Spondylitis	45.3%
3	Joint Tuberculosis	38.4%
4	Tuberculosis, Osteoarticular	38.4%
5	Bone Tuberculosis	38.4%
6	Discitis	33.3%
7	Tuberculosis, Spinal	28.7%
8	Mastoiditis	27.5%
9	Petrositis	27.5%
10	Osteoarthropathy, Secondary Hypertrophic	20.7%
11	Bone Diseases, Developmental	20.5%
12	Hyperostosis	20.5%
13	Osteitis	20.5%
14	Osteitis Deformans	20.5%
15	Osteochondrosis	20.5%
16	Pelvic Infection	20.5%
17	Spinal Diseases	20.5%
18	Wound Infection	20.5%
19	Soft Tissue Infection	20.5%
20	Community-Acquired Infections	20.5%
21	Arthritis, Infectious	18.6%
22	Osteochondritis	16.4%
23	Bone Diseases, Endocrine	16.1%
24	Eye Infection	16.1%
25	Respiratory Tract Infections	16.1%
26	Gigantism	16%
27	Spinal Neoplasms	16%
28	Bone neoplasms	15.5%
29	Osteopenia	15.5%
30	Pregnancy Complications, Infectious	15.5%
31	Skin Diseases, Infectious	15.5%
32	Platybasia	15.5%
33	Bone Resorption	15.3%
34	Aseptic Necrosis of Bone	15.3%
35	Suppuration	15.3%
36	Cross Infection	15.1%
37	Septicemia	15.1%
38	Sepsis	15.1%
39	Endotoxemia	13.7%
40	Ulcerative stomatitis	13.6%
41	Cellulitis	13.4%
42	Ainhum	13.3%
43	Dysostoses	13.3%
44	Spinal Stenosis	13.3%
45	Spondylosis	13.3%
46	Intervertebral Disc Degeneration	13.3%
47	Opportunistic Infections	13.2%
48	Arthritis, Reactive	13.2%
49	Urinary tract infection	12.3%
50	Dermatomycoses	12.2%
51	Skin Diseases, Bacterial	12.2%
52	Pectus excavatum	12.2%
53	Bacteremia	12%
54	Bacterial Infections	11.9%
55	Fasciitis	11.9%
56	Foot Deformities	11.9%
57	Arthropathy	11.9%
58	Mycoses	11.9%
59	Hidradenitis Suppurativa	11.7%
60	Pectus carinatum	11.7%
61	Pyomyositis	10.6%
62	Sexually Transmitted Diseases	10.6%
63	Fungemia	10.6%
64	Arthrogryposis	10.3%
65	Contracture	10.3%
66	Mycetoma	10.3%
67	Fasciitis, Plantar	10.3%
68	Bacterial Endocarditis	10.2%
69	Endophthalmitis	10.2%
70	Multiple Epiphyseal Dysplasia	10.2%
71	Osteochondrodysplasias	10.2%
72	Peritonitis	10.2%
73	Klippel-Feil Syndrome	10.1%
74	Pertussis	10.1%
75	Synostosis	10.1%
76	Congenital Hypothyroidism	10%
77	Osteoporosis	10%
78	Surgical Wound Infection	10%
79	Bone Demineralization, Pathologic	10%
80	Post-Traumatic Osteoporosis	10%
81	Abscess	9.9%
82	Adnexitis	9.9%
83	Alveolar Bone Loss	9.9%
84	Empyema	9.9%
85	Femur Head Necrosis	9.9%
86	Pelvic Inflammatory Disease	9.9%
87	Osteolysis	9.9%
88	Chondrodysplasia Punctata	9.9%
89	Enchondromatosis	9.9%
90	Lordosis	9.9%
91	Osteosclerosis	9.9%
92	Spondylolysis	9.9%
93	Psoas Abscess	9.9%
94	Abdominal Abscess	9.9%
95	kyphosis	9.9%
96	Kashin-Beck Disease	9.9%
97	Osteoarthritis, Spine	9.5%
98	Candidiasis, Chronic Mucocutaneous	9.3%
99	Cutaneous Candidiasis	9.3%
100	Jaw Diseases	9.3%
101	Cartilage Diseases	8.9%
102	Central Nervous System Infection	8.9%
103	Foot Diseases	8.9%
104	Myopathy	8.9%
105	Rheumatism	8.9%
106	Chondromalacia	8.9%
107	Erysipelas	8.7%
108	Staphylococcal Skin Infections	8.7%
109	Rheumatic Fever	8.7%
110	Ankylosing spondylitis	8.6%
111	Spondylarthropathies	8.6%
112	Chromoblastomycosis	8.6%
113	Craniofacial Dysostosis	8.6%
114	Dermatophytosis	8.6%
115	Sporotrichosis	8.6%
116	Tinea	8.6%
117	Tinea Versicolor	8.6%
118	Trichophytosis	8.6%
119	Hyalohyphomycosis	8.6%
120	Eosinophilic Granuloma	8.5%
121	Dwarfism	8.5%
122	Erythrasma	8.4%
123	Brain Abscess	8.4%
124	Candidemia	8.3%
125	Fibromyalgia	8.2%
126	Polymyalgia Rheumatica	8.2%
127	Superinfection	8.2%
128	Central Nervous System Bacterial Infections	8.2%
129	Melorheostosis	8.2%
130	Osteopetrosis	8.2%
131	Spondylolisthesis	8.2%
132	Metatarsalgia	8.2%
133	Corneal Ulcer	8.1%
134	Puerperal Infection	8%
135	Appendicitis	7.9%
136	Bacteriuria	7.9%
137	Pyuria	7.9%
138	Acromegaly	7.9%
139	Endotoxic shock	7.9%
140	Septic Shock	7.9%
141	Toxic Shock Syndrome	7.9%
142	Syphilis	7.7%
143	Panophthalmitis	7.6%
144	Ecthyma	7.5%
145	Subacute Bacterial Endocarditis	7.5%
146	Chlamydia Infections	7.5%
147	Gonorrhea	7.5%
148	Erythema Chronicum Migrans	7.4%
149	Impetigo	7.4%
150	Diverticulitis	7.4%
151	Osteoporosis, Postmenopausal	7.4%
152	Hordeolum	7.3%
153	Craniosynostosis	7.3%
154	Syndactyly	7.3%
155	Brachycephaly	7.3%
156	Arthritis, Psoriatic	7.2%
157	Bacterial conjunctivitis	7.2%
158	Blastomycosis	7%
159	Staphylococcal Scalded Skin Syndrome	7%
160	Acrocephalosyndactylia	6.8%
161	Arthritis	6.8%
162	Aspergillosis	6.8%
163	Bursitis	6.8%
164	Candidiasis	6.8%
165	Coccidioidomycosis	6.8%
166	Histoplasmosis	6.8%
167	Joint Instability	6.8%
168	Myofascial Pain Syndromes	6.8%
169	Paracoccidioidomycosis	6.8%
170	Rhabdomyolysis	6.8%
171	Synovitis	6.8%
172	Zygomycosis	6.8%
173	Gram-Negative Bacterial Infections	6.8%
174	Gram-Positive Bacterial Infections	6.8%
175	Joint laxity	6.8%
176	Polyarthritis	6.8%
177	Phaeohyphomycosis	6.8%
178	Fusariosis	6.8%
179	Frozen shoulder	6.8%
180	Pneumocystis Infections	6.8%
181	Patellofemoral Pain Syndrome	6.8%
182	Borrelia Infections	6.7%
183	Gout	6.7%
184	Hip Contracture	6.7%
185	Leptospirosis	6.7%
186	Periarthritis	6.7%
187	Ischemic contracture	6.7%
188	Rickets	6.6%
189	Temporomandibular Joint Disorders	6.4%
190	Liver Abscess	6.3%
191	carbuncle	6.2%
192	Lung Abscess	6.1%
193	Furunculosis	6.1%
194	furuncle	6.1%
195	Osteogenesis Imperfecta	6%
196	Diverticulum	6%
197	Diverticulosis	6%
198	Lymphogranuloma Venereum	6%
199	Goldenhar Syndrome	6%
200	Lyme Disease	5.9%
201	Poland Syndrome	5.9%
202	Relapsing Fever	5.9%
203	Rhinoscleroma	5.8%
204	Osteoarthritis, Knee	5.8%
205	AIDS-Related Opportunistic Infections	5.8%
206	Talipes	5.7%
207	Tinea Capitis	5.7%
208	Onychomycosis	5.7%
209	Mandibulofacial Dysostosis	5.7%
210	Rheumatoid Arthritis	5.7%
211	Juvenile arthritis	5.7%
212	Pseudohypoparathyroidism	5.7%
213	Temporomandibular Joint Dysfunction Syndrome	5.6%
214	Antley-Bixler Syndrome Phenotype	5.4%
215	Lyme Neuroborreliosis	5.3%
216	Ophthalmia Neonatorum	5.3%
217	Trachoma	5.3%
218	Neuroaspergillosis	5.3%
219	Compartment syndromes	5.2%
220	Maxillary Diseases	5.2%
221	Otomycosis	5.2%
222	Tendinitis	5.2%
223	Tendinopathy	5.2%
224	Hemarthrosis	5.1%
225	Myositis	5.1%
226	Piedra	5.1%
227	Tietze's Syndrome	5.1%
228	Limb Deformities, Congenital	5.1%
229	Isaacs syndrome	5.1%
230	Craniofacial Abnormalities	5.1%
231	Myotonic Disorders	5.1%
232	Central Nervous System Fungal Infections	5.1%
233	Bacterial Vaginosis	5%
234	Retropharyngeal Abscess	5%
235	Epidural Abscess	4.9%
236	Human Ehrlichiosis	4.9%
237	Neurosyphilis	4.9%
238	Peritonsillar Abscess	4.9%
239	Osteomalacia	4.9%
240	Tinea Pedis	4.9%
241	Rubinstein-Taybi Syndrome	4.8%
242	Palatal Neoplasms	4.7%
243	Arthritis, Gouty	4.7%
244	Rheumatoid Nodule	4.6%
245	Invasive Pulmonary Aspergillosis	4.6%
246	Erythema Induratum	4.6%
247	Marfan Syndrome	4.5%
248	Japanese Spotted Fever	4.5%
249	Basal Cell Nevus Syndrome	4.5%
250	Actinomycetales Infections	4.4%
251	Bordetella Infections	4.4%
252	Brucellosis	4.4%
253	Bunion	4.4%
254	Campylobacter infection	4.4%
255	Clostridium Infections	4.4%
256	Congenital clubfoot	4.4%
257	Enterobacteriaceae Infections	4.4%
258	Fibrodysplasia Ossificans Progressiva	4.4%
259	Listeriosis	4.4%
260	Mucormycosis	4.4%
261	Myoglobinuria	4.4%
262	Myositis Ossificans	4.4%
263	Pseudomonas Infections	4.4%
264	Q Fever	4.4%
265	Staphylococcal Infections	4.4%
266	Streptococcal Infections	4.4%
267	Tenosynovitis	4.4%
268	Vibrio Infections	4.4%
269	Helicobacter Infections	4.4%
270	Bacillaceae Infections	4.4%
271	Neisseriaceae Infections	4.4%
272	Vertical Talus	4.4%
273	Burkholderia Infections	4.4%
274	Clostridium difficile infection	4.4%
275	Sacroiliitis	4.4%
276	Flavobacteriaceae Infections	4.4%
277	Moraxellaceae Infections	4.4%
278	Burkholderia cepacia Infection	4.4%
279	Lung Diseases, Fungal	4.2%
280	Toxoplasmosis, Cerebral	4.2%
281	Medial Tibial Stress Syndrome	4.1%
282	Human anaplasmosis	4.1%
283	Pneumonia, Bacterial	4.1%
284	Mitochondrial Myopathies	4.1%
285	Muscle Cramp	4%
286	Eosinophilia-Myalgia Syndrome	4%
287	Gastroschisis	4%
288	Muscle Rigidity	4%
289	Muscle Spasticity	4%
290	Cogwheel Rigidity	4%
291	Nuchal Rigidity	4%
292	Rocky Mountain Spotted Fever	3.9%
293	Felty Syndrome	3.8%
294	Meningitis, Cryptococcal	3.8%
295	Jaw Abnormalities	3.8%
296	Cockayne Syndrome	3.7%
297	Chronic Fatigue Syndrome	3.5%
298	Erysipelothrix infection	3.5%
299	Prognathism	3.4%
300	Nail-Patella Syndrome	3.4%
301	Nose Neoplasms	3.4%
302	Oral candidiasis	3.4%
303	Giant Cell Epulis	3.4%
304	Muscle Weakness	3.4%
305	Musculoskeletal Pain	3.4%
306	Anterior Compartment Syndrome	3.3%
307	Familial Periodic Paralysis	3.3%
308	Enthesopathy	3.3%
309	Arthritis, Experimental	3.3%
310	Abdominal Compartment Syndrome	3.3%
311	Pulmonary Aspergillosis	3.3%
312	Bronchopulmonary Aspergillosis	3.3%
313	Arthralgia	3.3%
314	Polyarthralgia	3.3%
315	Syphilis, Congenital	3.3%
316	Amelia	3.3%
317	Arachnodactyly	3.3%
318	Ectromelia	3.3%
319	Hemimelia	3.3%
320	Phocomelia	3.3%
321	Sirenomelia	3.3%
322	Polymyositis	3.3%
323	Polydactyly	3.3%
324	Brachydactyly	3.3%
325	Plagiocephaly	3.3%
326	Lower Extremity Deformities, Congenital	3.3%
327	Upper Extremity Deformities, Congenital	3.3%
328	Acinetobacter Infections	3.3%
329	Actinomycosis	3.3%
330	Bacteroides Infections	3.3%
331	Cholera	3.3%
332	Corynebacterium Infections	3.3%
333	Escherichia coli Infections	3.3%
334	Gas Gangrene	3.3%
335	Haemophilus Infections	3.3%
336	Klebsiella Infections	3.3%
337	Meningococcal Infections	3.3%
338	Mycobacterium Infections	3.3%
339	Mycoplasma Infections	3.3%
340	Nocardia Infections	3.3%
341	Pasteurella Infections	3.3%
342	Pneumococcal Infections	3.3%
343	Proteus Infections	3.3%
344	Rickettsia Infections	3.3%
345	Salmonella infections	3.3%
346	Scarlet Fever	3.3%
347	Scrub Typhus	3.3%
348	Tetanus	3.3%
349	Serratia Infections	3.3%
350	Ureaplasma Infections	3.3%
351	Pulmonary Nocardiosis	3.3%
352	Rheumatoid Vasculitis	3.3%
353	Meningitis, Listeria	3.3%
354	Renal Osteodystrophy	3.3%
355	Renal rickets	3.3%
356	Liver Abscess, Amebic	3.2%
357	Meningitis, Haemophilus	3%
358	Meningitis, Pneumococcal	3%
359	Laryngomalacia	2.9%
360	Sicca Syndrome	2.9%
361	Sjogren's Syndrome	2.9%
362	Myalgia	2.8%
363	Hip Dislocation	2.7%
364	Shoulder Dislocation	2.7%
365	Hip Dysplasia	2.7%
366	Diphtheria	2.7%
367	Leprosy	2.7%
368	Mycobacterium Infections, Nontuberculous	2.7%
369	Psittacosis	2.7%
370	Paratyphoid Fever	2.7%
371	Plague	2.7%
372	Tuberculosis	2.7%
373	Typhoid Fever	2.7%
374	TYPHUS	2.7%
375	Yersinia pseudotuberculosis Infections	2.7%
376	Bubonic Plague	2.7%
377	Mycobacterium abscessus Infection	2.7%
378	Muscular Dystrophy	2.7%
379	Orbital Myositis	2.7%
380	Dupuytren Contracture	2.7%
381	Meningitis, Bacterial	2.6%
382	Meningitis, Fungal	2.6%
383	Micrognathism	2.6%
384	Pierre Robin Syndrome	2.6%
385	Candidiasis, Vulvovaginal	2.6%
386	Myotonic Dystrophy	2.6%
387	Mycobacterium avium-intracellulare Infection	2.5%
388	Lymph Node Tuberculosis	2.5%
389	Tuberculosis, Miliary	2.5%
390	Tuberculosis, Multidrug-Resistant	2.5%
391	Leprosy, Multibacillary	2.5%
392	Latent Tuberculosis	2.5%
393	Tuberculosis, Meningeal	2.4%
394	Retrognathia	2.4%
395	Borderline leprosy	2.3%
396	Leprosy, Lepromatous	2.3%
397	Tuberculoid leprosy	2.3%
398	Extensively Drug-Resistant Tuberculosis	2.3%
399	Maxillofacial Abnormalities	2.2%
400	Myotonia Congenita	2.2%
401	Bronchomalacia	2.2%
402	Tracheomalacia	2.2%
403	Microcephaly	2.2%
404	Macrocephaly	2.2%
405	Hypokalemic periodic paralysis	2.2%
406	Shoulder Pain	2.2%
407	Salmonella Infections, Animal	2.2%
408	Rheumatic Heart Disease	2.1%
409	Salmonella food poisoning	2.1%
410	Welander Distal Myopathy	2%
411	Enterocolitis, Pseudomembranous	2%
412	pseudomembranous colitis	2%
413	Dysentery, Bacillary	2%
414	Cleft Palate	1.9%
415	Tuberculosis, Gastrointestinal	1.9%
416	Mitochondrial Encephalomyopathies	1.9%
417	Tuberculosis, Central Nervous System	1.8%
418	Familial Hypophosphatemic Rickets	1.7%
419	Dermatomyositis	1.7%
420	Botulism	1.7%
421	Noonan Syndrome	1.7%
422	Muscular Dystrophy, Duchenne	1.6%
423	Porencephaly	1.6%
424	Tuberculosis, Pulmonary	1.5%
425	Holoprosencephaly	1.5%
426	Aspergillosis, Allergic Bronchopulmonary	1.4%
427	Waterhouse-Friderichsen Syndrome	1.4%
428	Radicular Cyst	1.2%
429	Lemierre Syndrome	1%
430	Tuberculosis, Renal	1%
431	MELAS Syndrome	0.9%
432	Kearns-Sayre syndrome	0.8%

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