MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thrombasthenia

(UMLS:C0040015)

Definition:: A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
UMLS ID:: C0040015
MeSH ID:: D013915

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.100.820|C15.378.140.810|C15.378.463.810

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.099.820

Synonym(s)

Thrombasthenia

GLANZMANN DISEASE

GLANZMANN THROMBASTHENIA

Glanzmann Thrombasthenia

Glanzmann thromboasthenia

Glanzmann's disease

Glanzmann's syndrome

Glanzmann's thrombasthenia

Glanzmann's thrombosthenin disorder

10.

Glanzmann-Naegeli disorder

11.

Glanzsmann's disease

12.

Glycoprotein IIb/IIIa defect

13.

Hereditary haemorrhagic thrombasthenia

14.

Hereditary hemorrhagic thrombasthenia

15.

Hereditary thromboasthenia

16.

Hereditary thromboasthenia, NOS

17.

Thrombasthenia, NOS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	ribociclib	FAERS: 4		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Afibrinogenemia	64.6%
2	Factor VII Deficiency	64.6%
3	Factor X Deficiency	64.6%
4	Factor XII Deficiency	64.6%
5	Hemophilia A	64.6%
6	Factor II deficiency	64.6%
7	Factor VIII Deficiency	64.6%
8	Factor V deficiency	64.6%
9	Factor XI Deficiency	64.6%
10	Hypoprothrombinemias	64.6%
11	Thrombocythemia, Essential	61.4%
12	Disseminated Intravascular Coagulation	60.2%
13	Antithrombin III Deficiency	58.7%
14	Protein C Deficiency	58.7%
15	Activated Protein C Resistance	58%
16	Protein S Deficiency	52.6%
17	Wiskott-Aldrich Syndrome	51.6%
18	Vitamin K Deficiency	44.2%
19	Thrombocytosis	40.1%
20	Anemia	34.2%
21	Bone Marrow Diseases	34.2%
22	Leukocyte Disorders	34.2%
23	Methemoglobinemia	34.2%
24	Pancytopenia	34.2%
25	Polycythemia	34.2%
26	Sulfhemoglobinemia	34.2%
27	Thrombophilia	34.2%
28	Erythrocytosis	34.2%
29	Thrombocytopenia	32.5%
30	Anemia, Sickle Cell	31.5%
31	Thalassemia	31.5%
32	Bone Marrow Neoplasms	31.3%
33	Anemia, Diamond-Blackfan	30.6%
34	Purpura, Thrombotic Thrombocytopenic	30.6%
35	Autoimmune thrombocytopenia	30.2%
36	Immune thrombocytopenic purpura	30.2%
37	Transfusion Reaction	29.5%
38	Hypotensive Transfusion Reaction	29.5%
39	Polycythemia Vera	29.4%
40	Pregnancy Complications, Hematologic	28.8%
41	Hematologic Neoplasms	28.8%
42	Pelger-Huet Anomaly	28.5%
43	Hemoglobinuria, Paroxysmal	26.2%
44	Leukemoid Reaction	26.2%
45	Thrombasthenia	24.8%
46	Purpura, Hyperglobulinemic	24.7%
47	Cryoglobulinemia	24.7%
48	Blood Coagulation Disorders	24.2%
49	Sickle Cell Trait	24.1%
50	Thrombotic Microangiopathies	23.7%
51	Waldenstrom Macroglobulinemia	23.4%
52	Thrombocytopenic purpura	22.8%
53	Blood Platelet Disorders	22.1%
54	Hemorrhagic Disorders	22.1%
55	Anemia, Hemolytic	21.9%
56	Anemia, Macrocytic	21.9%
57	Eosinophilia	21.9%
58	Hypoproteinemia	21.9%
59	Leukopenia	21.9%
60	Leukostasis	21.9%
61	MYELODYSPLASTIC SYNDROME	21.9%
62	Anemia, Neonatal	21.8%
63	Hemolytic-Uremic Syndrome	21.7%
64	Ecchymosis	21.3%
65	Petechiae	21.3%
66	Purpura	21.3%
67	Agammaglobulinemia	21.1%
68	Fanconi Anemia	20.9%
69	Waterhouse-Friderichsen Syndrome	20.2%
70	Lymphatic Diseases	20%
71	Multiple Myeloma	19.8%
72	Monoclonal Gammopathy of Undetermined Significance	19.8%
73	Acute Chest Syndrome	19.6%
74	Hydrops Fetalis	19.2%
75	Atypical Hemolytic Uremic Syndrome	18.5%
76	Leukocytosis	18.4%
77	Paraproteinemias	18.4%
78	Pleocytosis	18.4%
79	Infectious Mononucleosis	18.2%
80	Chronic granulomatous disease	17%
81	Shwartzman Phenomenon	17%
82	Hemangioma, Cavernous	16.9%
83	Scurvy	16.8%
84	Heavy Chain Disease	16.5%
85	Hypergammaglobulinemia	15.9%
86	Primary Myelofibrosis	15.8%
87	Agranulocytosis	15.8%
88	Anemia, Megaloblastic	15.8%
89	Lymphocytosis	15.8%
90	Myelofibrosis	15.8%
91	Myeloid Metaplasia	15.8%
92	Hypoalbuminemia	15.8%
93	Hypereosinophilic syndrome	15.8%
94	bone marrow fibrosis	15.8%
95	Pseudoxanthoma Elasticum	15.8%
96	Transfusion-Related Acute Lung Injury	15.7%
97	Purpura Fulminans	15%
98	Lymphopenia	13.3%
99	Job Syndrome	13.2%
100	Leukemia, Myelomonocytic, Chronic	13.1%
101	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	13.1%
102	Lymphatic Abnormalities	13%
103	Neutropenia	12.8%
104	Kernicterus	12.3%
105	Lymphangiectasis, Intestinal	12.3%
106	Autoimmune Lymphoproliferative Syndrome	12.2%
107	Eosinophilic Granuloma	11.8%
108	POEMS Syndrome	11.5%
109	Eosinophilia-Myalgia Syndrome	11.4%
110	Adenitis	11.4%
111	Histiocytosis	11.4%
112	Lymphadenitis	11.4%
113	Lymphangitis	11.4%
114	Lymphedema	11.4%
115	Splenic Diseases	11.4%
116	Thymus Hyperplasia	11.4%
117	Pseudolymphoma	11.4%
118	Lymphadenopathy	11.4%
119	Febrile Neutropenia	11.3%
120	Aicardi's syndrome	11.1%
121	Fragile X Syndrome	10.8%
122	Pulmonary Eosinophilia	10.8%
123	Eosinophilic Pneumonia	10.8%
124	Leukemia, Myeloid, Chronic-Phase	10.6%
125	Anemia, Pernicious	10.6%
126	CHARGE Syndrome	10.5%
127	Neoplastic Syndromes, Hereditary	10.4%
128	Cystic Fibrosis	10.3%
129	Ichthyosis, X-Linked	10.1%
130	Multiple Epiphyseal Dysplasia	10.1%
131	Osteochondrodysplasias	10.1%
132	Werner Syndrome	10.1%
133	Myasthenic Syndromes, Congenital	10.1%
134	Albinism	9.9%
135	Muscular Dystrophy, Duchenne	9.9%
136	Lymphocele	9.6%
137	Lymphoproliferative Disorders	9.6%
138	Thymus Neoplasms	9.5%
139	Beckwith-Wiedemann Syndrome	9.5%
140	Wolf-Hirschhorn Syndrome	9.5%
141	Nail-Patella Syndrome	9.3%
142	Cockayne Syndrome	9.3%
143	Alstrom Syndrome	9.1%
144	Mucopolysaccharidosis II	8.9%
145	Dwarfism	8.9%
146	Muscular Dystrophy	8.6%
147	Osteogenesis Imperfecta	8.6%
148	Rett Syndrome	8.4%
149	Smith-Magenis syndrome	8.4%
150	Menkes Kinky Hair Syndrome	8.4%
151	Cri-du-Chat Syndrome	8.3%
152	Down Syndrome	8.3%
153	Trisomy 21	8.3%
154	Mucocutaneous Lymph Node Syndrome	8.1%
155	Kartagener Syndrome	8.1%
156	Familial Mediterranean Fever	7.9%
157	Holoprosencephaly	7.8%
158	Marfan Syndrome	7.6%
159	Angioedemas, Hereditary	7.4%
160	Ectodermal Dysplasia	7.4%
161	Aplasia Cutis Congenita	7.4%
162	Prader-Willi Syndrome	7.3%
163	Elephantiasis	7.3%
164	Hypersplenism	7.3%
165	Sarcoidosis	7.3%
166	Elephantiasis Nostras Verrucosa	7.3%
167	Smith-Lemli-Opitz Syndrome	7.2%
168	Myotonic Dystrophy	7.2%
169	Neuronal Ceroid-Lipofuscinoses	7.1%
170	Adrenoleukodystrophy	7%
171	Deformity	6.9%
172	Rubinstein-Taybi Syndrome	6.9%
173	Tuberous Sclerosis	6.9%
174	Kallmann Syndrome	6.7%
175	Sjogren-Larsson Syndrome	6.7%
176	Amino Acid Metabolism, Inborn Errors	6.6%
177	Carbohydrate Metabolism, Inborn Errors	6.6%
178	Metal Metabolism, Inborn Errors	6.6%
179	Progeria	6.6%
180	Lysosomal Storage Diseases	6.6%
181	Cytochrome-c Oxidase Deficiency	6.6%
182	Peroxisomal Disorders	6.6%
183	Hepatolenticular Degeneration	6.6%
184	Polycystic Kidney Diseases	6.6%
185	Williams Syndrome	6.6%
186	Primary Ciliary Dyskinesia	6.5%
187	Refsum Disease	6.5%
188	Fabry Disease	6.5%
189	Amyloid Neuropathies, Familial	6.2%
190	Granuloma	6.1%
191	Histiocytic Disorders, Malignant	6.1%
192	Splenic Infarction	6.1%
193	Splenic Neoplasms	6.1%
194	Histiocytosis, Langerhans-Cell	6.1%
195	Tumor Lysis Syndrome	6.1%
196	Retinal Dysplasia	6%
197	Glycogen storage disease type II	6%
198	Aniridia	6%
199	Sezary Syndrome	5.9%
200	Epidermolysis Bullosa	5.9%
201	Galactosemias	5.9%
202	Urea Cycle Disorders, Inborn	5.9%
203	Tyrosinemias	5.9%
204	Niemann-Pick Disease, Type C	5.8%
205	Fetal Diseases	5.8%
206	Cutis Laxa	5.7%
207	Retinitis Pigmentosa	5.7%
208	Pigmentary retinopathy	5.7%
209	Porokeratosis	5.7%
210	Keratoderma, Palmoplantar	5.7%
211	Welander Distal Myopathy	5.6%
212	Ataxia Telangiectasia	5.5%
213	Mucopolysaccharidosis III	5.4%
214	Optic Atrophy, Hereditary, Leber	5.3%
215	Hyperphosphaturia	5.3%
216	Splenic Rupture	5.3%
217	Canavan Disease	5.3%
218	Alexander Disease	5.3%
219	Lymphohistiocytosis, Hemophagocytic	5.3%
220	Lymphoma	5.3%
221	Erdheim-Chester Disease	5.3%
222	Thymoma	5.2%
223	Zellweger Syndrome	5.2%
224	Duane Retraction Syndrome	5.1%
225	Porphyrias, Hepatic	5%
226	Gaucher Disease	5%
227	Peutz-Jeghers Syndrome	5%
228	Myotonia Congenita	5%
229	Brain Diseases, Metabolic, Inborn	5%
230	Classical Lissencephalies and Subcortical Band Heterotopias	5%
231	Dystonia Musculorum Deformans	4.9%
232	Alkaptonuria	4.9%
233	Glycogen Storage Disease	4.9%
234	Hypophosphatasia	4.9%
235	Propionic acidemia	4.9%
236	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
237	Cystinosis	4.9%
238	Homocystinuria	4.9%
239	Lafora Disease	4.9%
240	Unverricht-Lundborg Syndrome	4.9%
241	Leigh Disease	4.9%
242	Polycystic Kidney, Autosomal Dominant	4.9%
243	Hyperkeratosis, Epidermolytic	4.7%
244	Tay-Sachs Disease	4.5%
245	Meconium Aspiration Syndrome	4.5%
246	Multiple Endocrine Neoplasia	4.5%
247	Xeroderma Pigmentosum	4.5%
248	Congenital Hypothyroidism	4.4%
249	Dermatitis, Atopic	4.4%
250	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
251	Malignant histiocytosis	4.4%
252	Sarcoidosis, Pulmonary	4.4%
253	Histiocytic sarcoma	4.4%
254	Charcot-Marie-Tooth Disease	4.4%
255	Antley-Bixler Syndrome Phenotype	4.4%
256	Hypolipoproteinemias	4.2%
257	Papillon-Lefevre Disease	4.2%
258	Hyperlipidemia, Familial Combined	4.2%
259	Hyperlipoproteinemia Type III	4.2%
260	Xeroderma	4.2%
261	Mobius Syndrome	4.2%
262	Glycogen Storage Disease Type I	4.1%
263	Glycogen Storage Disease Type V	4.1%
264	Basal Cell Nevus Syndrome	4%
265	Abdominal Cramps	4%
266	Abnormalities, Drug-Induced	4%
267	Amniotic Band Syndrome	4%
268	Asphyxia Neonatorum	4%
269	Infant, Premature, Diseases	4%
270	Situs Inversus	4%
271	Infantile Colic	4%
272	Behcet Syndrome	4%
273	Splenosis	3.8%
274	Hodgkin Disease	3.8%
275	Lymphoma, Non-Hodgkin	3.8%
276	Leukemia, T-Cell	3.7%
277	Leukemia, B-Cell	3.7%
278	Familial Periodic Paralysis	3.7%
279	Lactose Intolerance	3.7%
280	Variegate Porphyria	3.7%
281	Acute intermittent porphyria	3.7%
282	Porphyria Cutanea Tarda	3.7%
283	Klinefelter Syndrome	3.7%
284	Hyperhomocysteinemia	3.7%
285	Renal Aminoacidurias	3.7%
286	Fanconi Syndrome	3.7%
287	Pseudohypoaldosteronism	3.7%
288	Liddle Syndrome	3.7%
289	Hyperlipoproteinemia Type IV	3.7%
290	Hyperlipoproteinemia Type V	3.7%
291	Huntington Disease	3.6%
292	Hypoalphalipoproteinemias	3.5%
293	Eye Abnormalities	3.5%
294	Cardiovascular Abnormalities	3.5%
295	Turner Syndrome	3.4%
296	Skin Abnormalities	3.4%
297	Congenital Microtia	3.4%
298	Persistent Fetal Circulation Syndrome	3.4%
299	Congenital diaphragmatic hernia	3.3%
300	Umbilical hernia	3.3%
301	Gout	3.3%
302	Anencephaly	3.3%
303	Multiple Endocrine Neoplasia Type 1	3.3%
304	Pseudohypoparathyroidism	3.3%
305	Composite Lymphoma	3.3%
306	Nephroblastoma	3.3%
307	Friedreich Ataxia	3.3%
308	Lymphangioleiomyomatosis	3.3%
309	Renal tubular acidosis	3.3%
310	Hypokalemic periodic paralysis	3.1%
311	Cystinuria	3%
312	Lymphoma, Follicular	3%
313	T-Cell Lymphoma	3%
314	Mantle cell lymphoma	3%
315	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3%
316	Leukemia, Large Granular Lymphocytic	3%
317	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3%
318	Adenomatous Polyposis Coli	3%
319	Familial Hypophosphatemic Rickets	3%
320	Urogenital Abnormalities	3%
321	Neonatal Abstinence Syndrome	2.9%
322	Maxillofacial Abnormalities	2.9%
323	Dural Arteriovenous Fistula	2.9%
324	Dextrocardia	2.9%
325	Fetal Growth Retardation	2.9%
326	Fetal Hypoxia	2.9%
327	Congenital nystagmus	2.9%
328	Fetal Alcohol Spectrum Disorders	2.9%
329	Toxoplasmosis, Congenital	2.8%
330	Syphilis, Congenital	2.8%
331	Arthritis, Gouty	2.7%
332	Lymphoma, T-Cell, Cutaneous	2.7%
333	Lymphoma, AIDS-Related	2.7%
334	Enteropathy-Associated T-Cell Lymphoma	2.7%
335	Primary Effusion Lymphoma	2.7%
336	Glycosuria, Renal	2.7%
337	Prune Belly Syndrome	2.6%
338	Twins, Conjoined	2.6%
339	Waardenburg Syndrome	2.6%
340	Congenital Hyperinsulinism	2.5%
341	Chorioamnionitis	2.5%
342	Mycosis Fungoides	2.5%
343	Lymphomatoid Papulosis	2.5%
344	Plasmablastic lymphoma	2.5%
345	Scimitar Syndrome	2.4%
346	Lymphomatoid Granulomatosis	2.4%
347	Denys-Drash Syndrome	2.3%
348	Acrocephalosyndactylia	2.3%
349	Microcephaly	2.2%
350	Macrocephaly	2.2%
351	MELAS Syndrome	2.2%
352	Anophthalmos	2.2%
353	Anus, Imperforate	2.2%
354	Hydranencephaly	2.2%
355	Microphthalmos	2.2%
356	Neural Tube Defects	2.2%
357	Paralysis, Obstetric	2.2%
358	Retinopathy of Prematurity	2.2%
359	Tethered Cord Syndrome	2.2%
360	Iniencephaly	2.2%
361	Craniorachischisis	2.2%
362	Limb Deformities, Congenital	2.2%
363	Exencephaly	2.2%
364	Septo-Optic Dysplasia	2.2%
365	Craniofacial Abnormalities	2.2%
366	Cortical Dysplasia	2.2%
367	Malformations of Cortical Development	2.2%
368	Anorectal Malformations	2.2%
369	Abnormalities, Radiation-Induced	2.2%
370	Bloom Syndrome	2.2%
371	Bronchopulmonary Dysplasia	2.2%
372	Craniosynostosis	2.2%
373	Syndactyly	2.2%
374	Brachycephaly	2.2%
375	Burkitt Lymphoma	2.1%
376	Porencephaly	2%
377	Noonan Syndrome	2%
378	Ophthalmia Neonatorum	2%
379	Cleft Palate	1.9%
380	Blepharophimosis	1.9%
381	Laryngostenosis	1.9%
382	Mouth Abnormalities	1.9%
383	Respiratory Distress Syndrome, Newborn	1.9%
384	Esophageal Atresia	1.9%
385	Intestinal Atresia	1.9%
386	Horseshoe Kidney	1.9%
387	Pectus excavatum	1.9%
388	Klippel-Feil Syndrome	1.9%
389	Gastroschisis	1.9%
390	Synostosis	1.9%
391	Acrodermatitis	1.9%
392	Gianotti-Crosti Syndrome	1.9%
393	Jaw Abnormalities	1.8%
394	Poland Syndrome	1.8%
395	Arthrogryposis	1.7%
396	Choanal Atresia	1.7%
397	Tracheobronchomegaly	1.7%
398	Laryngocele	1.7%
399	Choledochal Cyst	1.7%
400	Hermaphroditism	1.7%
401	Disorders of Sex Development	1.7%
402	Cryptorchidism	1.7%
403	Hypospadias	1.7%
404	Central Nervous System Cysts	1.7%
405	Dandy-Walker Syndrome	1.7%
406	Amelia	1.6%
407	Arachnodactyly	1.6%
408	Ectopia Cordis	1.6%
409	Ectromelia	1.6%
410	Hemimelia	1.6%
411	Meningomyelocele	1.6%
412	Phocomelia	1.6%
413	Sirenomelia	1.6%
414	Spina Bifida	1.6%
415	Polydactyly	1.6%
416	Brachydactyly	1.6%
417	Plagiocephaly	1.6%
418	Lower Extremity Deformities, Congenital	1.6%
419	Upper Extremity Deformities, Congenital	1.6%
420	Single umbilical artery	1.6%
421	Leukomalacia, Periventricular	1.6%
422	Nesidioblastosis	1.6%
423	Micrognathism	1.5%
424	Pierre Robin Syndrome	1.5%
425	Laryngomalacia	1.5%
426	Pectus carinatum	1.5%
427	Bladder Exstrophy	1.5%
428	Epispadias	1.5%
429	Multicystic Dysplastic Kidney	1.5%
430	Aortic coarctation	1.4%
431	Cor Triatriatum	1.4%
432	Coronary Vessel Anomalies	1.4%
433	Dental Enamel Hypoplasia	1.4%
434	Patent ductus arteriosus	1.4%
435	Ebstein Anomaly	1.4%
436	Heart Septal Defects	1.4%
437	Hyaline Membrane Disease	1.4%
438	Hypodontia	1.4%
439	Macrostomia	1.4%
440	Meningocele	1.4%
441	Microstomia	1.4%
442	Tetralogy of Fallot	1.4%
443	Transposition of Great Vessels	1.4%
444	Hypoplastic Left Heart Syndrome	1.4%
445	May-Thurner Syndrome	1.4%
446	Encephalocele	1.4%
447	Retrognathia	1.4%
448	Craniofacial Dysostosis	1.4%
449	Wolff-Parkinson-White Syndrome	1.4%
450	Dermal Sinus	1.4%
451	Spina Bifida Cystica	1.4%
452	Spina Bifida Occulta	1.4%
453	Lissencephaly	1.4%
454	Polymicrogyria	1.4%
455	Pachygyria	1.4%
456	Schizencephaly	1.4%
457	Periventricular Nodular Heterotopia	1.4%
458	Hyperandrogenism	1.3%
459	Prognathism	1.3%
460	Long QT Syndrome	1.2%
461	Platybasia	1.2%
462	Tricuspid Atresia	1.2%
463	Arrhythmogenic Right Ventricular Dysplasia	1.2%
464	Gonadal Dysgenesis	1.2%
465	Bronchomalacia	1.2%
466	Adrenogenital Syndrome	1.2%
467	Tracheomalacia	1.2%
468	Ovotesticular Disorders of Sex Development	1.2%
469	Aortopulmonary Septal Defect	1.2%
470	Double Outlet Right Ventricle	1.2%
471	Endocardial Cushion Defects	1.2%
472	Myocardial bridging	1.2%
473	Aorticopulmonary Septal Defect	1.2%
474	Truncus Arteriosus, Persistent	1%
475	Goldenhar Syndrome	1%
476	Mandibulofacial Dysostosis	1%
477	Romano-Ward Syndrome	1%
478	Talipes	0.9%
479	Congenital clubfoot	0.9%
480	Vertical Talus	0.9%
481	Arteriovenous fistula	0.8%

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