MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Peroxisomal Disorders

(UMLS:C0282528)

Definition:: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.
UMLS ID:: C0282528
MeSH ID:: D018901

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.663

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.663

Synonym(s)

Peroxisomal Disorders

Disorder of Peroxisomal Function

Disorder of peroxisomal function

Peroxisomal Disorder

Peroxisomal Function Disorder

Peroxisomal disorder, unspecified

Peroxisomal disorders

peroxisomal biogenesis disorder

peroxisomal disorder

10.

peroxisomal disorders

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	pipecolic acid		10642506	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Amino Acid Metabolism, Inborn Errors	46.7%
2	Carbohydrate Metabolism, Inborn Errors	46.7%
3	Metal Metabolism, Inborn Errors	46.7%
4	Progeria	46.7%
5	Lysosomal Storage Diseases	46.7%
6	Smith-Lemli-Opitz Syndrome	39.6%
7	Galactosemias	37.7%
8	Urea Cycle Disorders, Inborn	37.7%
9	Tyrosinemias	37.7%
10	Brain Diseases, Metabolic, Inborn	37.6%
11	Glycogen storage disease type II	36%
12	Leigh Disease	35.3%
13	Alkaptonuria	34.4%
14	Glycogen Storage Disease	34.4%
15	Hypophosphatasia	34.4%
16	Propionic acidemia	34.4%
17	Dihydropyrimidine Dehydrogenase Deficiency	34.4%
18	Cystinosis	34.4%
19	Hyperphosphaturia	33.5%
20	Hypolipoproteinemias	33.3%
21	Cytochrome-c Oxidase Deficiency	33.3%
22	Mucopolysaccharidosis III	32.3%
23	Hyperlipidemia, Familial Combined	32.2%
24	Carbamoyl-Phosphate Synthase I Deficiency Disease	32.1%
25	Hyperlipoproteinemia Type III	31.7%
26	Gaucher Disease	31.5%
27	Homocystinuria	31.2%
28	Pseudohypoparathyroidism	31.1%
29	Hyperhomocysteinemia	30.6%
30	Menkes Kinky Hair Syndrome	30%
31	Hyperlipoproteinemia Type IV	29.9%
32	Hyperlipoproteinemia Type V	29.9%
33	Lactose Intolerance	29.5%
34	Tay-Sachs Disease	28.6%
35	Glycogen Storage Disease Type I	28.5%
36	Glycogen Storage Disease Type V	28.5%
37	Mucopolysaccharidosis II	28.3%
38	Fabry Disease	27.6%
39	Hypoalphalipoproteinemias	27.5%
40	Niemann-Pick Disease, Type C	27.1%
41	Hepatolenticular Degeneration	26.5%
42	Neuronal Ceroid-Lipofuscinoses	26.2%
43	Werner Syndrome	25.4%
44	Amyloid Neuropathies, Familial	25%
45	Albinism	24.4%
46	Renal tubular acidosis	23.7%
47	Familial Periodic Paralysis	23.3%
48	Familial Hypophosphatemic Rickets	23.3%
49	Renal Aminoacidurias	22.8%
50	Fanconi Syndrome	22.8%
51	Pseudohypoaldosteronism	22.8%
52	Liddle Syndrome	22.8%
53	Ichthyosis, X-Linked	21.8%
54	Antley-Bixler Syndrome Phenotype	21%
55	Wasting Syndrome	20.7%
56	Acid-Base Imbalance	20.5%
57	Calcium Metabolism Disorders	20.5%
58	Iron Metabolism Disorders	20.5%
59	Phosphorus Metabolism Disorders	20.5%
60	Water-Electrolyte Imbalance	20.5%
61	Lipid Metabolism Disorders	20.5%
62	Mitochondrial Diseases	20.5%
63	Glucose Metabolism Disorders	20.5%
64	Gout	20%
65	Hypercalcemia	20%
66	Hypocalcemia	20%
67	Milk-Alkali Syndrome	20%
68	Adrenoleukodystrophy	20%
69	Hypokalemic periodic paralysis	19%
70	Cystinuria	18.8%
71	Sjogren-Larsson Syndrome	18.7%
72	Glycosuria, Renal	18.3%
73	Canavan Disease	17.7%
74	Alexander Disease	17.7%
75	MELAS Syndrome	17.2%
76	Cockayne Syndrome	16.6%
77	Arthritis, Gouty	16.3%
78	Neoplastic Syndromes, Hereditary	16.1%
79	Lipodystrophy	16%
80	Refsum Disease	15.7%
81	Osteopenia	15.5%
82	Brain Diseases, Metabolic	15.3%
83	Multiple Epiphyseal Dysplasia	15.3%
84	Osteochondrodysplasias	15.3%
85	Pelger-Huet Anomaly	15.3%
86	Myasthenic Syndromes, Congenital	15.3%
87	Zellweger Syndrome	15%
88	CHARGE Syndrome	14.9%
89	Rickets	14.4%
90	Cystic Fibrosis	14%
91	Aicardi's syndrome	13.9%
92	Fragile X Syndrome	13.9%
93	Porphyrias, Hepatic	13.5%
94	Congenital Hyperinsulinism	13.5%
95	Acidosis	13.3%
96	Alkalosis	13.3%
97	Amyloidosis	13.3%
98	Beckwith-Wiedemann Syndrome	13.3%
99	Bloom Syndrome	13.3%
100	Calcinosis	13.3%
101	Hyperglycemia	13.3%
102	Hyperinsulinism	13.3%
103	Hyperkalemia	13.3%
104	Hypernatremia	13.3%
105	Hypoglycemia	13.3%
106	Hypokalemia	13.3%
107	Hyponatremia	13.3%
108	Familial Mediterranean Fever	13.3%
109	Xanthomatosis	13.3%
110	Hypophosphatemia	13.3%
111	Metabolic acidosis	13.3%
112	Dyslipidemias	13.3%
113	Iron Overload	13.3%
114	Xanthoma	13.3%
115	Wolf-Hirschhorn Syndrome	13.3%
116	Anemia, Sickle Cell	13.2%
117	Thalassemia	13.2%
118	Muscular Dystrophy, Duchenne	13.2%
119	Fanconi Anemia	13.1%
120	Dwarfism	12.7%
121	Nail-Patella Syndrome	12.5%
122	Muscular Dystrophy	12.1%
123	Osteogenesis Imperfecta	12.1%
124	Deformity	11.9%
125	Nutrition Disorders	11.9%
126	Rett Syndrome	11.7%
127	Smith-Magenis syndrome	11.2%
128	Ataxia Telangiectasia	11.2%
129	Cri-du-Chat Syndrome	11%
130	Down Syndrome	11%
131	Trisomy 21	11%
132	Optic Atrophy, Hereditary, Leber	10.9%
133	Osteomalacia	10.9%
134	Prader-Willi Syndrome	10.8%
135	Diabetic Ketoacidosis	10.8%
136	Alstrom Syndrome	10.7%
137	Diabetes Mellitus	10.5%
138	Nesidioblastosis	10.4%
139	Autoimmune Lymphoproliferative Syndrome	10.2%
140	Dehydration	10.2%
141	Lipomatosis	10.2%
142	Water Intoxication	10.2%
143	Achlorhydria	10%
144	Osteoporosis	10%
145	Bone Demineralization, Pathologic	10%
146	Post-Traumatic Osteoporosis	10%
147	Angioedemas, Hereditary	9.9%
148	Celiac Disease	9.9%
149	Sprue, Tropical	9.9%
150	Steatorrhea	9.9%
151	Sprue	9.9%
152	Wiskott-Aldrich Syndrome	9.9%
153	Acidosis, Lactic	9.9%
154	Calciphylaxis	9.9%
155	Hemosiderosis	9.9%
156	Ketosis	9.9%
157	Ketonuria	9.9%
158	Ketoacidosis	9.9%
159	Ketonemia	9.9%
160	Vascular calcification	9.9%
161	Mitochondrial Encephalomyopathies	9.9%
162	Variegate Porphyria	9.8%
163	Acute intermittent porphyria	9.8%
164	Porphyria Cutanea Tarda	9.8%
165	Friedreich Ataxia	9.8%
166	Sickle Cell Trait	9.7%
167	Holoprosencephaly	9.6%
168	Ectodermal Dysplasia	9.5%
169	Aplasia Cutis Congenita	9.5%
170	Xeroderma Pigmentosum	9.4%
171	Marfan Syndrome	9.4%
172	Kartagener Syndrome	9.3%
173	Fetal Diseases	8.9%
174	Primary Ciliary Dyskinesia	8.9%
175	Myotonic Dystrophy	8.8%
176	Polycystic Kidney Diseases	8.8%
177	Williams Syndrome	8.8%
178	Kallmann Syndrome	8.4%
179	Rubinstein-Taybi Syndrome	8.4%
180	Hypercholesterolemia	8.2%
181	Hyperlipoproteinemias	8.2%
182	Hypertriglyceridemia	8.2%
183	Tuberous Sclerosis	8.2%
184	Cutis Laxa	8.1%
185	Mitochondrial Myopathies	8.1%
186	Retinitis Pigmentosa	8.1%
187	Myelinolysis, Central Pontine	8.1%
188	Pigmentary retinopathy	8.1%
189	Porokeratosis	8%
190	Keratoderma, Palmoplantar	8%
191	Glycosuria	7.9%
192	Chronic granulomatous disease	7.9%
193	Reye Syndrome	7.9%
194	Hepatic Encephalopathy	7.9%
195	Welander Distal Myopathy	7.9%
196	Retinal Dysplasia	7.8%
197	Aniridia	7.8%
198	Epidermolysis Bullosa	7.6%
199	HIV Wasting Syndrome	7.5%
200	Acute Chest Syndrome	7.5%
201	Acidosis, Respiratory	7.4%
202	Adiposis Dolorosa	7.4%
203	Alkalosis, Respiratory	7.4%
204	Insulin Resistance	7.4%
205	Osteoporosis, Postmenopausal	7.4%
206	HIV-Associated Lipodystrophy Syndrome	7.3%
207	Renal Osteodystrophy	7.3%
208	Renal rickets	7.3%
209	Abdominal Cramps	6.8%
210	Abnormalities, Drug-Induced	6.8%
211	Amniotic Band Syndrome	6.8%
212	Asphyxia Neonatorum	6.8%
213	Child Nutrition Disorders	6.8%
214	Duane Retraction Syndrome	6.8%
215	Hypervitaminosis A	6.8%
216	Infant Nutrition Disorders	6.8%
217	Infant, Premature, Diseases	6.8%
218	Situs Inversus	6.8%
219	Malnutrition	6.8%
220	Infantile Colic	6.8%
221	Kernicterus	6.7%
222	Peutz-Jeghers Syndrome	6.6%
223	Wernicke Encephalopathy	6.6%
224	Myotonia Congenita	6.6%
225	Thrombasthenia	6.6%
226	Antithrombin III Deficiency	6.6%
227	Necrobiosis Lipoidica Diabeticorum	6.6%
228	Protein C Deficiency	6.6%
229	Afibrinogenemia	6.6%
230	Dystonia Musculorum Deformans	6.6%
231	Factor VII Deficiency	6.6%
232	Factor X Deficiency	6.6%
233	Factor XII Deficiency	6.6%
234	Hemophilia A	6.6%
235	Activated Protein C Resistance	6.6%
236	Factor II deficiency	6.6%
237	Factor VIII Deficiency	6.6%
238	Factor V deficiency	6.6%
239	Factor XI Deficiency	6.6%
240	Hypoprothrombinemias	6.6%
241	Lafora Disease	6.5%
242	Unverricht-Lundborg Syndrome	6.5%
243	Anemia, Diamond-Blackfan	6.5%
244	Polycystic Kidney, Autosomal Dominant	6.5%
245	Classical Lissencephalies and Subcortical Band Heterotopias	6.3%
246	Gestational Diabetes	6.1%
247	Latent Autoimmune Diabetes in Adults	6.1%
248	Diabetes Mellitus, Experimental	6%
249	Pseudoxanthoma Elasticum	5.9%
250	Nephrocalcinosis	5.9%
251	Tetany	5.9%
252	Meconium Aspiration Syndrome	5.9%
253	Multiple Endocrine Neoplasia	5.9%
254	Papillon-Lefevre Disease	5.9%
255	Hyperkeratosis, Epidermolytic	5.9%
256	Cerebral Amyloid Angiopathy	5.8%
257	Congenital Hypothyroidism	5.7%
258	Dermatitis, Atopic	5.7%
259	Xeroderma	5.6%
260	Mobius Syndrome	5.6%
261	Charcot-Marie-Tooth Disease	5.6%
262	Eye Abnormalities	5.4%
263	Cardiovascular Abnormalities	5.4%
264	Kearns-Sayre syndrome	5.3%
265	Skin Abnormalities	5.2%
266	Lymphatic Abnormalities	5.2%
267	Congenital Microtia	5.2%
268	Anemia, Neonatal	5.1%
269	Persistent Fetal Circulation Syndrome	5.1%
270	Congenital diaphragmatic hernia	5%
271	Umbilical hernia	5%
272	Behcet Syndrome	5%
273	Primary amyloidosis	5%
274	Basal Cell Nevus Syndrome	4.8%
275	Anencephaly	4.6%
276	Klinefelter Syndrome	4.5%
277	Deficiency Diseases	4.4%
278	Prune Belly Syndrome	4.4%
279	Starvation	4.4%
280	Twins, Conjoined	4.4%
281	Refeeding Syndrome	4.4%
282	Waardenburg Syndrome	4.4%
283	Huntington Disease	4.4%
284	Urogenital Abnormalities	4.3%
285	Amyotrophic Lateral Sclerosis	4.3%
286	Multiple Endocrine Neoplasia Type 1	4.2%
287	Hydrops Fetalis	4.2%
288	Neonatal Abstinence Syndrome	4.2%
289	Fetal Growth Retardation	4.1%
290	Frontotemporal dementia	4.1%
291	Fetal Hypoxia	4%
292	Congenital nystagmus	4%
293	Fetal Alcohol Spectrum Disorders	4%
294	Toxoplasmosis, Congenital	4%
295	Syphilis, Congenital	4%
296	Nephroblastoma	3.9%
297	Maxillofacial Abnormalities	3.9%
298	Dural Arteriovenous Fistula	3.9%
299	Turner Syndrome	3.9%
300	Dextrocardia	3.9%
301	CREST Syndrome	3.7%
302	Adenomatous Polyposis Coli	3.5%
303	Anophthalmos	3.4%
304	Anus, Imperforate	3.4%
305	Hydranencephaly	3.4%
306	Microphthalmos	3.4%
307	Neural Tube Defects	3.4%
308	Paralysis, Obstetric	3.4%
309	Retinopathy of Prematurity	3.4%
310	Tethered Cord Syndrome	3.4%
311	Iniencephaly	3.4%
312	Craniorachischisis	3.4%
313	Limb Deformities, Congenital	3.4%
314	Exencephaly	3.4%
315	Septo-Optic Dysplasia	3.4%
316	Craniofacial Abnormalities	3.4%
317	Cortical Dysplasia	3.4%
318	Malformations of Cortical Development	3.4%
319	Anorectal Malformations	3.4%
320	Chorioamnionitis	3.4%
321	Bronchopulmonary Dysplasia	3.3%
322	Kwashiorkor	3.3%
323	Magnesium Deficiency	3.3%
324	Potassium Deficiency	3.3%
325	Protein Deficiency	3.3%
326	Avitaminosis	3.3%
327	Microcephaly	3%
328	Macrocephaly	3%
329	Scimitar Syndrome	3%
330	Abnormalities, Radiation-Induced	2.9%
331	Craniosynostosis	2.8%
332	Syndactyly	2.8%
333	Brachycephaly	2.8%
334	Blepharophimosis	2.7%
335	Laryngostenosis	2.7%
336	Mouth Abnormalities	2.7%
337	Respiratory Distress Syndrome, Newborn	2.7%
338	Ascorbic Acid Deficiency	2.7%
339	Vitamin A Deficiency	2.7%
340	Vitamin D Deficiency	2.7%
341	Vitamin E Deficiency	2.7%
342	Marasmus	2.7%
343	Esophageal Atresia	2.7%
344	Intestinal Atresia	2.7%
345	Horseshoe Kidney	2.7%
346	Pectus excavatum	2.7%
347	Porencephaly	2.7%
348	Klippel-Feil Syndrome	2.7%
349	Gastroschisis	2.7%
350	Synostosis	2.7%
351	Acrocephalosyndactylia	2.7%
352	Acrodermatitis	2.7%
353	Lymphangiectasis, Intestinal	2.7%
354	Gianotti-Crosti Syndrome	2.7%
355	Denys-Drash Syndrome	2.6%
356	Noonan Syndrome	2.5%
357	Amelia	2.5%
358	Arachnodactyly	2.5%
359	Ectopia Cordis	2.5%
360	Ectromelia	2.5%
361	Hemimelia	2.5%
362	Meningomyelocele	2.5%
363	Phocomelia	2.5%
364	Sirenomelia	2.5%
365	Spina Bifida	2.5%
366	Polydactyly	2.5%
367	Brachydactyly	2.5%
368	Plagiocephaly	2.5%
369	Lower Extremity Deformities, Congenital	2.5%
370	Upper Extremity Deformities, Congenital	2.5%
371	Single umbilical artery	2.5%
372	Ophthalmia Neonatorum	2.5%
373	Folic Acid Deficiency	2.5%
374	Pellagra	2.5%
375	Thiamine Deficiency	2.5%
376	Vitamin B 12 Deficiency	2.5%
377	Vitamin B 6 Deficiency	2.5%
378	Pyridoxine Deficiency	2.5%
379	Beriberi	2.3%
380	Poland Syndrome	2.3%
381	Cleft Palate	2.3%
382	Arthrogryposis	2.3%
383	Choanal Atresia	2.3%
384	Tracheobronchomegaly	2.3%
385	Laryngocele	2.3%
386	Jaw Abnormalities	2.3%
387	Choledochal Cyst	2.3%
388	Hermaphroditism	2.3%
389	Disorders of Sex Development	2.3%
390	Cryptorchidism	2.2%
391	Hypospadias	2.2%
392	Central Nervous System Cysts	2.2%
393	Dandy-Walker Syndrome	2.2%
394	Leukomalacia, Periventricular	2.2%
395	POEMS Syndrome	2.2%
396	Obesity	2.2%
397	Dermal Sinus	2%
398	Spina Bifida Cystica	2%
399	Spina Bifida Occulta	2%
400	Lissencephaly	2%
401	Polymicrogyria	2%
402	Pachygyria	2%
403	Schizencephaly	2%
404	Periventricular Nodular Heterotopia	2%
405	Aortic coarctation	2%
406	Cor Triatriatum	2%
407	Coronary Vessel Anomalies	2%
408	Dental Enamel Hypoplasia	2%
409	Patent ductus arteriosus	2%
410	Ebstein Anomaly	2%
411	Heart Septal Defects	2%
412	Hyaline Membrane Disease	2%
413	Hypodontia	2%
414	Macrostomia	2%
415	Meningocele	2%
416	Microstomia	2%
417	Tetralogy of Fallot	2%
418	Transposition of Great Vessels	2%
419	Hypoplastic Left Heart Syndrome	2%
420	May-Thurner Syndrome	2%
421	Encephalocele	2%
422	Craniofacial Dysostosis	2%
423	Wolff-Parkinson-White Syndrome	2%
424	Laryngomalacia	2%
425	Pectus carinatum	1.9%
426	Obesity, Abdominal	1.9%
427	Micrognathism	1.9%
428	Pierre Robin Syndrome	1.9%
429	Bladder Exstrophy	1.9%
430	Epispadias	1.9%
431	Multicystic Dysplastic Kidney	1.9%
432	Retrognathia	1.7%
433	Anemia, Pernicious	1.7%
434	Long QT Syndrome	1.7%
435	Platybasia	1.7%
436	Tricuspid Atresia	1.7%
437	Arrhythmogenic Right Ventricular Dysplasia	1.7%
438	Vitamin K Deficiency	1.7%
439	Gonadal Dysgenesis	1.6%
440	Bronchomalacia	1.6%
441	Adrenogenital Syndrome	1.6%
442	Tracheomalacia	1.6%
443	Ovotesticular Disorders of Sex Development	1.6%
444	Aortopulmonary Septal Defect	1.6%
445	Double Outlet Right Ventricle	1.6%
446	Endocardial Cushion Defects	1.6%
447	Myocardial bridging	1.6%
448	Aorticopulmonary Septal Defect	1.6%
449	Hyperandrogenism	1.6%
450	Pediatric Obesity	1.6%
451	Prognathism	1.6%
452	Scurvy	1.5%
453	Truncus Arteriosus, Persistent	1.5%
454	Goldenhar Syndrome	1.5%
455	Mandibulofacial Dysostosis	1.4%
456	Romano-Ward Syndrome	1.4%
457	Talipes	1.2%
458	Congenital clubfoot	1.1%
459	Vertical Talus	1.1%
460	Arteriovenous fistula	1%
461	Subacute Combined Degeneration	1%

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