MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Peutz-Jeghers Syndrome

(UMLS:C0031269)

Definition:: A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.
UMLS ID:: C0031269
MeSH ID:: D010580

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.700.633

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.578.750

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.700.667

Classification 4:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.430.530.550.625

Synonym(s)

Peutz-Jeghers Syndrome

INTESTINAL POLYPOSIS-CUTANEOUS PIGMENTATION SYNDROME

Jeghers-Peutz Syndrome

PEUTZ-JEGHERS SYNDROME

PJS

PJS - Peutz-Jehgers syndrome

POLYPOSIS, INTESTINAL, II

Perioral lentiginosis

Periorificial lentiginosis syndrome

10.

Peutz's Syndrome

11.

Peutz-Jeghers polyposis

12.

Peutz-Jeghers syndrome

13.

Peutz-Jeghers' syndrome

14.

hereditary intestinal polyposis syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 1		US FAERS
2	Zoledronic Acid			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Adenomatous Polyposis Coli	29.5%
2	Multiple Endocrine Neoplasia	24.9%
3	Tuberous Sclerosis	21.4%
4	Zollinger-Ellison syndrome	19.4%
5	Multiple Endocrine Neoplasia Type 1	18.3%
6	Colorectal Neoplasms	17.7%
7	Basal Cell Nevus Syndrome	17.6%
8	Nephroblastoma	17.1%
9	Xeroderma Pigmentosum	16.7%
10	Dysentery	16.6%
11	Enteritis	16.6%
12	Enterocolitis	16.6%
13	Inflammatory Bowel Diseases	16.6%
14	Duodenitis	15.9%
15	Ileitis	15.9%
16	Erosive Duodenitis	15.9%
17	Intestinal Neoplasms	15.7%
18	Proctocolitis	15.7%
19	Duodenal Obstruction	15.3%
20	Acanthosis Nigricans	15.3%
21	Cecal Neoplasms	14.7%
22	Duodenal Neoplasms	14.7%
23	Albinism	14.6%
24	Intestinal Atresia	14.4%
25	Cecal Diseases	13.9%
26	Colonic Diseases	13.9%
27	Ileal Diseases	13.9%
28	Intestinal Obstruction	13.9%
29	Intestinal Perforation	13.9%
30	Jejunal Diseases	13.9%
31	Pneumatosis Cystoides Intestinalis	13.9%
32	Rectal Diseases	13.9%
33	Ichthyosis, X-Linked	13.7%
34	Epidermolysis Bullosa	13.4%
35	Rectal Fistula	12.7%
36	Anal Fistula	12.7%
37	Colitis	12.7%
38	Duodenogastric Reflux	12.7%
39	Peptic Ulcer	12.7%
40	Proctitis	12.7%
41	Gastrointestinal Neoplasms	12.6%
42	Mesenteric vascular insufficiency	12.6%
43	Cystic Fibrosis	12.5%
44	Mesenteric Vascular Occlusion	12.5%
45	Intestinal Fistula	12.4%
46	Enterocutaneous Fistula	12.4%
47	Ectodermal Dysplasia	12.4%
48	Aplasia Cutis Congenita	12.4%
49	Nail-Patella Syndrome	12.1%
50	Porokeratosis	12.1%
51	Keratoderma, Palmoplantar	12.1%
52	Intestinal Diseases, Parasitic	12%
53	Anus Neoplasms	11.9%
54	Sigmoid Neoplasms	11.9%
55	Dermatitis, Atopic	11.9%
56	Pouchitis	11.8%
57	Esophageal Neoplasms	11.8%
58	Skin Neoplasms	11.7%
59	Appendiceal Neoplasms	11.2%
60	Colonic Neoplasms	11.2%
61	Rectal Neoplasms	11.2%
62	Urticaria Pigmentosa	11.1%
63	Aicardi's syndrome	11.1%
64	Cutis Laxa	11%
65	Crohn Disease	10.9%
66	Enterocolitis, Neutropenic	10.9%
67	Necrotizing Enterocolitis	10.9%
68	Appendicitis	10.9%
69	Fragile X Syndrome	10.9%
70	Stomach Neoplasms	10.8%
71	Skin Abnormalities	10.6%
72	CHARGE Syndrome	10.5%
73	Colonic Pseudo-Obstruction	10.5%
74	Sjogren-Larsson Syndrome	10.2%
75	Pseudoxanthoma Elasticum	10.2%
76	Denys-Drash Syndrome	10.2%
77	Esophageal Diseases	10.1%
78	Gastroenteritis	10.1%
79	Stomach Diseases	10.1%
80	Multiple Epiphyseal Dysplasia	10.1%
81	Osteochondrodysplasias	10.1%
82	Pelger-Huet Anomaly	10.1%
83	Werner Syndrome	10.1%
84	Myasthenic Syndromes, Congenital	10.1%
85	Esophagitis	10%
86	Gastritis	10%
87	Porphyrias, Hepatic	9.9%
88	Menkes Kinky Hair Syndrome	9.9%
89	Anemia, Sickle Cell	9.9%
90	Thalassemia	9.9%
91	Muscular Dystrophy, Duchenne	9.9%
92	Xeroderma	9.8%
93	Digestive System Neoplasms	9.8%
94	Osteogenesis Imperfecta	9.7%
95	Lupus Erythematosus, Cutaneous	9.6%
96	Panniculitis	9.6%
97	Systemic Scleroderma	9.6%
98	Morphea	9.6%
99	Pyoderma Gangrenosum	9.6%
100	Barrett Esophagus	9.5%
101	Beckwith-Wiedemann Syndrome	9.5%
102	Wolf-Hirschhorn Syndrome	9.5%
103	Pruritus Ani	9.5%
104	Lactose Intolerance	9.4%
105	Enterocolitis, Pseudomembranous	9.4%
106	pseudomembranous colitis	9.4%
107	Dysentery, Bacillary	9.4%
108	Peritoneal Neoplasms	9.3%
109	Cockayne Syndrome	9.3%
110	Sebaceous Gland Neoplasms	9.3%
111	Colonic Diseases, Functional	9.2%
112	Fecal Incontinence	9.2%
113	Fecal Impaction	9.2%
114	Intussusception	9.2%
115	Megacolon	9.2%
116	Ileus	9.2%
117	Meconium ileus	9.2%
118	Mucopolysaccharidosis II	9.2%
119	Alstrom Syndrome	9.1%
120	Duodenal Ulcer	9%
121	Peptic Ulcer Perforation	9%
122	Gastric ulcer	9%
123	Marfan Syndrome	8.9%
124	Dwarfism	8.9%
125	Argyria	8.7%
126	Esophageal Atresia	8.6%
127	Muscular Dystrophy	8.6%
128	Breast Diseases	8.6%
129	Dermatitis	8.6%
130	Exanthema	8.6%
131	Facial Dermatoses	8.6%
132	Hair Diseases	8.6%
133	Hand Dermatoses	8.6%
134	keratoacanthoma	8.6%
135	Keratosis	8.6%
136	Nail Diseases	8.6%
137	Photosensitivity Disorders	8.6%
138	Prurigo	8.6%
139	Pyoderma	8.6%
140	Rosacea	8.6%
141	Sebaceous Gland Diseases	8.6%
142	Skin Diseases, Vesiculobullous	8.6%
143	Skin Ulcer	8.6%
144	Sweat Gland Diseases	8.6%
145	Skin Diseases, Papulosquamous	8.6%
146	Skin Diseases, Vascular	8.6%
147	Acneiform Eruptions	8.6%
148	Ocular Rosacea	8.6%
149	Subcorneal pustular dermatosis	8.6%
150	Erythematotelangiectatic Rosacea	8.6%
151	Papulopustular Rosacea	8.6%
152	Chronic Actinic Dermatitis	8.6%
153	Mastocytosis	8.5%
154	Choledochal Cyst	8.4%
155	Rett Syndrome	8.4%
156	Gastrointestinal Hemorrhage	8.4%
157	Smith-Magenis syndrome	8.4%
158	Angioedemas, Hereditary	8.4%
159	Medulloblastoma	8.4%
160	Tuberculosis, Gastrointestinal	8.3%
161	Pancreatic Neoplasm	8.3%
162	Acrodermatitis	8.3%
163	Gianotti-Crosti Syndrome	8.3%
164	Hamartoma	8.3%
165	Neoplasms, Hormone-Dependent	8.3%
166	Neoplasms, Multiple Primary	8.3%
167	Paraneoplastic Syndromes	8.3%
168	Precancerous Conditions	8.3%
169	Neoplasms, Second Primary	8.3%
170	Carcinoma 256, Walker	8.3%
171	Cri-du-Chat Syndrome	8.3%
172	Down Syndrome	8.3%
173	Trisomy 21	8.3%
174	Breast Cyst	8.3%
175	Actinic keratosis	8.3%
176	Kartagener Syndrome	8.1%
177	Gastrointestinal Stromal Tumors	8%
178	Familial Mediterranean Fever	8%
179	Wiskott-Aldrich Syndrome	7.9%
180	Carcinoma, Lobular	7.9%
181	Melanoma, Experimental	7.8%
182	Holoprosencephaly	7.8%
183	Colitis, Ischemic	7.8%
184	Hemorrhoids	7.8%
185	Liver neoplasms	7.7%
186	Papillon-Lefevre Disease	7.7%
187	Afferent Loop Syndrome	7.7%
188	Celiac Disease	7.7%
189	Short Bowel Syndrome	7.7%
190	Sprue, Tropical	7.7%
191	Steatorrhea	7.7%
192	Rectocele	7.7%
193	Sprue	7.7%
194	Hepatolenticular Degeneration	7.7%
195	Rectal Prolapse	7.7%
196	Autoimmune Lymphoproliferative Syndrome	7.6%
197	Neoplasms, Neuroepithelial	7.5%
198	Gliomatosis cerebri	7.5%
199	Acne Vulgaris	7.5%
200	Behcet Syndrome	7.5%
201	Contact Dermatitis	7.5%
202	Eczema	7.5%
203	Erythema Multiforme	7.5%
204	Intertrigo	7.5%
205	Neurodermatitis	7.5%
206	Rhinophyma	7.5%
207	Perioral Dermatitis	7.5%
208	Acne	7.5%
209	Foot Diseases	7.4%
210	Hyperkeratosis, Epidermolytic	7.4%
211	Carcinoma, Pancreatic Ductal	7.4%
212	Pancreatic Cyst	7.4%
213	Prader-Willi Syndrome	7.3%
214	Sickle Cell Trait	7.3%
215	Carcinoma, Ehrlich Tumor	7.2%
216	Dermoid Cyst	7.2%
217	Carcinoma, Lewis Lung	7.2%
218	Skin Diseases, Infectious	7.2%
219	Smith-Lemli-Opitz Syndrome	7.2%
220	Myotonic Dystrophy	7.2%
221	Lipomatosis	7.1%
222	Pruritus	7.1%
223	Erythema	7.1%
224	Necrolytic Migratory Erythema	7.1%
225	Cutaneous Fistula	7.1%
226	Nephrogenic Fibrosing Dermopathy	7.1%
227	Nephrogenic Systemic Fibrosis	7.1%
228	Dermatomyositis	7.1%
229	Neuronal Ceroid-Lipofuscinoses	7.1%
230	Adrenoleukodystrophy	7%
231	Liver Neoplasms, Experimental	7%
232	melanoma	7%
233	Cyst	6.9%
234	Neoplastic Processes	6.9%
235	Pregnancy Complications, Neoplastic	6.9%
236	Deformity	6.9%
237	Anal Fissure	6.9%
238	Intestinal Pseudo-Obstruction	6.9%
239	Irritable Bowel Syndrome	6.9%
240	Superior Mesenteric Artery Syndrome	6.9%
241	Neurogenic Bowel	6.9%
242	Anal Ulcer	6.9%
243	Rubinstein-Taybi Syndrome	6.9%
244	Neoplasms, Experimental	6.9%
245	Meningioma	6.8%
246	Paraneoplastic Encephalomyelitis	6.8%
247	Kallmann Syndrome	6.7%
248	Giardiasis	6.7%
249	Trophoblastic Neoplasms	6.7%
250	Leukemia, Experimental	6.7%
251	Mammary Neoplasms, Experimental	6.7%
252	Amino Acid Metabolism, Inborn Errors	6.6%
253	Carbohydrate Metabolism, Inborn Errors	6.6%
254	Esophageal and Gastric Varices	6.6%
255	Metal Metabolism, Inborn Errors	6.6%
256	Progeria	6.6%
257	Lysosomal Storage Diseases	6.6%
258	Neuroectodermal Tumors	6.6%
259	Cytochrome-c Oxidase Deficiency	6.6%
260	Peroxisomal Disorders	6.6%
261	Hepatocellular Adenoma	6.6%
262	Polycystic Kidney Diseases	6.6%
263	Williams Syndrome	6.6%
264	Primary Ciliary Dyskinesia	6.5%
265	Adenoma, Acidophil	6.5%
266	Ganglioneuroma	6.5%
267	Glioma	6.5%
268	Malignant Glioma	6.5%
269	Refsum Disease	6.5%
270	Dermatitis Herpetiformis	6.5%
271	Fabry Disease	6.5%
272	Variegate Porphyria	6.5%
273	Acute intermittent porphyria	6.5%
274	Porphyria Cutanea Tarda	6.5%
275	Choriocarcinoma	6.3%
276	Zellweger Syndrome	6.3%
277	Vipoma	6.3%
278	Carcinoid Tumor	6.3%
279	Neurilemmoma	6.3%
280	Hutchinson's Melanotic Freckle	6.3%
281	Melanoma, Amelanotic	6.3%
282	Amyloid Neuropathies, Familial	6.2%
283	Biliary Tract Diseases	6.2%
284	Liver diseases	6.2%
285	Pancreatic Diseases	6.2%
286	Mastocytoma	6.2%
287	Homocystinuria	6.2%
288	Sarcoma, Experimental	6.2%
289	Necrobiosis Lipoidica Diabeticorum	6.1%
290	Carcinosarcoma	6.1%
291	Hemangiosarcoma	6.1%
292	Leukemia L1210	6.1%
293	Leukemia P388	6.1%
294	lymphangiosarcoma	6.1%
295	Acanthoma	6.1%
296	Retinal Dysplasia	6%
297	Glycogen storage disease type II	6%
298	Astrocytoma	6%
299	Ependymoma	6%
300	oligodendroglioma	6%
301	Ganglioglioma	6%
302	gliosarcoma	6%
303	Anaplastic astrocytoma	6%
304	Anaplastic Oligodendroglioma	6%
305	Aniridia	6%
306	Esophageal Stenosis	6%
307	Gastric Dilatation	6%
308	Gastric outlet obstruction	6%
309	Acute Chest Syndrome	6%
310	Malignant Carcinoid Syndrome	5.9%
311	Neoplasms, Radiation-Induced	5.9%
312	Leukemia, Radiation-Induced	5.9%
313	Galactosemias	5.9%
314	Urea Cycle Disorders, Inborn	5.9%
315	Tyrosinemias	5.9%
316	Mucopolysaccharidosis III	5.9%
317	Bile Duct Neoplasms	5.8%
318	gallbladder neoplasm	5.8%
319	Fetal Diseases	5.8%
320	Glioblastoma	5.8%
321	Neuroblastoma	5.8%
322	Glioblastoma Multiforme	5.8%
323	Foot Ulcer	5.8%
324	Panniculitis, Lupus Erythematosus	5.8%
325	Vitiligo	5.8%
326	Sarcoma 180	5.8%
327	Myxoid cyst	5.7%
328	Retinitis Pigmentosa	5.7%
329	Pigmentary retinopathy	5.7%
330	Connective Tissue Diseases	5.7%
331	Retinoblastoma	5.7%
332	insulinoma	5.7%
333	Chronic granulomatous disease	5.7%
334	Ganglioneuroblastoma	5.7%
335	Welander Distal Myopathy	5.6%
336	Acoustic Neuroma	5.6%
337	Gastrinoma	5.6%
338	Glucagonoma	5.6%
339	Ataxia Telangiectasia	5.5%
340	Basal cell carcinoma	5.5%
341	Carcinoma, Papillary	5.5%
342	Squamous cell carcinoma	5.5%
343	Chondrosarcoma	5.5%
344	Craniopharyngioma	5.5%
345	Cystadenoma	5.5%
346	leiomyosarcoma	5.5%
347	liposarcoma	5.5%
348	Mesothelioma	5.5%
349	synovial sarcoma	5.5%
350	Neuroectodermal Tumor, Melanotic	5.5%
351	Angiomyolipoma	5.5%
352	Clear Cell Sarcoma of Soft Tissue	5.5%
353	Alveolar Soft Part Sarcoma	5.5%
354	Neuroendocrine Tumors	5.5%
355	Sarcoma, Myeloid	5.5%
356	Carcinoma, Basal Cell	5.5%
357	Abdominal Neoplasms	5.4%
358	Erythroplasia	5.4%
359	Follicular cyst	5.4%
360	Head and Neck Neoplasms	5.4%
361	leukemia	5.4%
362	Mucocele	5.4%
363	Neoplasms, Germ Cell and Embryonal	5.4%
364	Neoplasms, Glandular and Epithelial	5.4%
365	Pilonidal Cyst	5.4%
366	Soft Tissue Neoplasms	5.4%
367	Thoracic Neoplasms	5.4%
368	Thyroglossal Cyst	5.4%
369	Synovial Cyst	5.4%
370	Germ Cell Cancer	5.4%
371	Aberrant Crypt Foci	5.4%
372	Breast Neoplasms, Male	5.4%
373	Triple Negative Breast Neoplasms	5.4%
374	Optic Atrophy, Hereditary, Leber	5.4%
375	Erythema Induratum	5.3%
376	Hyperphosphaturia	5.3%
377	Canavan Disease	5.3%
378	Alexander Disease	5.3%
379	Dermatitis, Phototoxic	5.3%
380	Pityriasis Lichenoides et Varioliformis Acuta	5.3%
381	Pityriasis Lichenoides	5.3%
382	Phototoxicity	5.3%
383	Thymoma	5.2%
384	Cystadenocarcinoma	5.2%
385	Fibrosarcoma	5.2%
386	Osteosarcoma	5.2%
387	Mucoepidermoid Carcinoma	5.2%
388	Leukemia, Plasma Cell	5.2%
389	Esophageal Perforation	5.2%
390	Lymphomatoid Granulomatosis	5.1%
391	Duane Retraction Syndrome	5.1%
392	Parathyroid Neoplasms	5.1%
393	Thyroid Neoplasm	5.1%
394	Thyroid carcinoma	5.1%
395	Carcinoid Heart Disease	5.1%
396	Adenofibroma	5%
397	Fibroadenoma	5%
398	Malignant Fibrous Histiocytoma	5%
399	Anus, Imperforate	5%
400	Deglutition Disorders	5%
401	Anorectal Malformations	5%
402	Optic Nerve Glioma	5%
403	Gaucher Disease	5%
404	Achlorhydria	5%
405	Lupus Erythematosus, Discoid	5%
406	Pancreatic Pseudocyst	5%
407	Gastric Antral Vascular Ectasia	5%
408	Scleroderma, Limited	5%
409	Myotonia Congenita	5%
410	Thrombasthenia	5%
411	Antithrombin III Deficiency	5%
412	Protein C Deficiency	5%
413	Brain Diseases, Metabolic, Inborn	5%
414	Classical Lissencephalies and Subcortical Band Heterotopias	5%
415	Peptic Ulcer Hemorrhage	5%
416	Gastroparesis	5%
417	Afibrinogenemia	4.9%
418	Dystonia Musculorum Deformans	4.9%
419	Factor VII Deficiency	4.9%
420	Factor X Deficiency	4.9%
421	Factor XII Deficiency	4.9%
422	Hemophilia A	4.9%
423	Composite Lymphoma	4.9%
424	Activated Protein C Resistance	4.9%
425	Factor II deficiency	4.9%
426	Factor VIII Deficiency	4.9%
427	Factor V deficiency	4.9%
428	Factor XI Deficiency	4.9%
429	Hypoprothrombinemias	4.9%
430	Alkaptonuria	4.9%
431	Glycogen Storage Disease	4.9%
432	Hypophosphatasia	4.9%
433	Propionic acidemia	4.9%
434	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
435	Cystinosis	4.9%
436	Fanconi Anemia	4.9%
437	Lafora Disease	4.9%
438	Unverricht-Lundborg Syndrome	4.9%
439	Anemia, Diamond-Blackfan	4.9%
440	Bowen's Disease	4.9%
441	Paraganglioma	4.9%
442	Rhabdomyosarcoma	4.9%
443	Giant Cell Tumor of Bone	4.9%
444	Leigh Disease	4.9%
445	Polycystic Kidney, Autosomal Dominant	4.9%
446	Pancreatic Fistula	4.8%
447	Dermatofibrosarcoma	4.8%
448	Dermatofibrosarcoma Protuberans	4.8%
449	Neurofibrosarcoma	4.8%
450	Cryptosporidiosis	4.7%
451	Endocrine Gland Neoplasms	4.6%
452	Eye Neoplasms	4.6%
453	Nervous System Neoplasms	4.6%
454	Tracheal Neoplasms	4.6%
455	Pheochromocytoma	4.6%
456	Alveolar rhabdomyosarcoma	4.6%
457	Congenital Hyperinsulinism	4.6%
458	Dermatitis, Photoallergic	4.6%
459	Leukoplakia, Oral	4.6%
460	Tay-Sachs Disease	4.5%
461	Meconium Aspiration Syndrome	4.5%
462	Paraneoplastic Cerebellar Degeneration	4.5%
463	Bone neoplasms	4.5%
464	Leukoplakia	4.5%
465	Lymphocele	4.5%
466	Hematologic Neoplasms	4.5%
467	Anhidrosis	4.5%
468	Cholesteatoma	4.5%
469	Pressure Ulcer	4.5%
470	Folliculitis	4.5%
471	Foot Dermatoses	4.5%
472	Gynecomastia	4.5%
473	Hypertrichosis	4.5%
474	Hypohidrosis	4.5%
475	Hypotrichosis	4.5%
476	Leg Ulcer	4.5%
477	Miliaria	4.5%
478	Parakeratosis	4.5%
479	Parapsoriasis	4.5%
480	Pityriasis	4.5%
481	Psoriasis	4.5%
482	Sweet Syndrome	4.5%
483	Hidradenitis	4.5%
484	Onycholysis	4.5%
485	Miliaria Rubra	4.5%
486	Lichenoid Eruptions	4.5%
487	Chloracne	4.5%
488	Histiocytic Disorders, Malignant	4.5%
489	Mediastinal Cyst	4.5%
490	Neoplasm Invasiveness	4.5%
491	Neoplasm Metastasis	4.5%
492	Neoplasm Recurrence, Local	4.5%
493	Parovarian Cyst	4.5%
494	Pericardial Cyst	4.5%
495	Splenic Neoplasms	4.5%
496	Thymic Cyst	4.5%
497	Carcinogenesis	4.5%
498	Metastasis	4.5%
499	Congenital Hypothyroidism	4.4%
500	Hydatidiform Mole	4.4%
501	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
502	Erythema Infectiosum	4.4%
503	Exanthema Subitum	4.4%
504	Charcot-Marie-Tooth Disease	4.4%
505	Antley-Bixler Syndrome Phenotype	4.4%
506	Niemann-Pick Disease, Type C	4.4%
507	Erythema Nodosum	4.3%
508	Melena	4.3%
509	Endometrial Stromal Sarcoma	4.3%
510	Hematemesis	4.2%
511	Hypolipoproteinemias	4.2%
512	Hyperlipidemia, Familial Combined	4.2%
513	Hyperlipoproteinemia Type III	4.2%
514	Mobius Syndrome	4.2%
515	Thyroid Nodule	4.1%
516	Dermatitis, Irritant	4.1%
517	Acne Conglobata	4.1%
518	Lymphangioleiomyomatosis	4.1%
519	Glycogen Storage Disease Type I	4.1%
520	Glycogen Storage Disease Type V	4.1%
521	Mesenteric Panniculitis	4.1%
522	Panniculitis, Peritoneal	4.1%
523	Dupuytren Contracture	4%
524	Abdominal Cramps	4%
525	Abnormalities, Drug-Induced	4%
526	Amniotic Band Syndrome	4%
527	Asphyxia Neonatorum	4%
528	Infant, Premature, Diseases	4%
529	Situs Inversus	4%
530	Infantile Colic	4%
531	Limbic Encephalitis	4%
532	Adenoma	4%
533	Ameloblastoma	4%
534	Angiokeratoma	4%
535	Carcinoma	4%
536	Chordoma	4%
537	Hemangioma	4%
538	hemangiopericytoma	4%
539	Lymphangioma	4%
540	Mesenchymoma	4%
541	Nevus	4%
542	Retroperitoneal Neoplasms	4%
543	Teratoma	4%
544	Hepatoblastoma	4%
545	Mixed Tumor, Mullerian	4%
546	Germinoma	4%
547	Teratocarcinoma	4%
548	Angiofibroma	4%
549	Sarcoma	4%
550	Epithelioma	4%
551	Esophageal motility disorders	4%
552	Mallory-Weiss Syndrome	4%
553	Pyloric Stenosis	4%
554	Leydig Cell Tumor	3.9%
555	Ecthyma	3.8%
556	Lymphoma	3.8%
557	Corpus Luteum Cyst	3.8%
558	Ovarian Cysts	3.8%
559	Granuloma Annulare	3.8%
560	Acantholysis	3.8%
561	Pemphigoid, Benign Mucous Membrane	3.8%
562	Pemphigus	3.8%
563	Piedra	3.8%
564	Sunburn	3.8%
565	Central Nervous System Cysts	3.8%
566	Familial Periodic Paralysis	3.7%
567	Hirsutism	3.7%
568	Lactation Disorder	3.7%
569	Mastitis	3.7%
570	Urticaria	3.7%
571	Adiposis Dolorosa	3.7%
572	Pruritus Vulvae	3.7%
573	Klinefelter Syndrome	3.7%
574	Hyperhomocysteinemia	3.7%
575	Toxic Epidermal Necrolysis	3.7%
576	Stevens-Johnson Syndrome	3.7%
577	Tinea Capitis	3.7%
578	Onychomycosis	3.7%
579	Renal Aminoacidurias	3.7%
580	Fanconi Syndrome	3.7%
581	Lambert-Eaton Myasthenic Syndrome	3.7%
582	Pseudohypoaldosteronism	3.7%
583	Testicular Neoplasms	3.7%
584	Liddle Syndrome	3.7%
585	Hyperlipoproteinemia Type IV	3.7%
586	Hyperlipoproteinemia Type V	3.7%
587	Prolactinoma	3.6%
588	Growth Hormone-Secreting Pituitary Adenoma	3.6%
589	Dermatitis, Occupational	3.6%
590	Huntington Disease	3.6%
591	Biliary cirrhosis	3.5%
592	Dermatitis, Allergic Contact	3.5%
593	Hypoalphalipoproteinemias	3.5%
594	Eye Abnormalities	3.5%
595	Cardiovascular Abnormalities	3.5%
596	Hydrops Fetalis	3.5%
597	Turner Syndrome	3.4%
598	Mesoblastic Nephroma	3.4%
599	Noonan Syndrome	3.4%
600	Lymphatic Abnormalities	3.4%
601	Congenital Microtia	3.4%
602	Bile Duct Diseases	3.4%
603	Cholelithiasis	3.4%
604	Chylous Ascites	3.4%
605	Fatty Liver	3.4%
606	Hepatitis	3.4%
607	Portal Hypertension	3.4%
608	Liver Cirrhosis	3.4%
609	Pancreatic Insufficiency	3.4%
610	Pancreatitis	3.4%
611	Pneumoperitoneum	3.4%
612	Focal Nodular Hyperplasia	3.4%
613	Hepatic Insufficiency	3.4%
614	Steatohepatitis	3.4%
615	Anemia, Neonatal	3.4%
616	Mouth Neoplasms	3.4%
617	Persistent Fetal Circulation Syndrome	3.4%
618	Central Nervous System Neoplasms	3.4%
619	Vascular Neoplasms	3.4%
620	Thymus Neoplasms	3.4%
621	Congenital diaphragmatic hernia	3.3%
622	Umbilical hernia	3.3%
623	Opsoclonus-Myoclonus Syndrome	3.3%
624	Gout	3.3%
625	Genital Neoplasms, Female	3.3%
626	Plasmacytoma	3.3%
627	Cholecystolithiasis	3.3%
628	Anencephaly	3.3%
629	Malignant histiocytosis	3.3%
630	Lymphatic Metastasis	3.3%
631	Neoplasms, Unknown Primary	3.3%
632	Leukemic Infiltration	3.3%
633	Histiocytic sarcoma	3.3%
634	Neoplasm Micrometastasis	3.3%
635	Pseudohypoparathyroidism	3.3%
636	Adenocarcinoma	3.3%
637	Carcinoma in Situ	3.3%
638	Carcinoma, Transitional Cell	3.3%
639	Phyllodes Tumor	3.3%
640	Dysgerminoma	3.3%
641	Hemangioendothelioma	3.3%
642	Lipoma	3.3%
643	Myoma	3.3%
644	Myxoma	3.3%
645	Neuroma	3.3%
646	Papilloma	3.3%
647	Pseudomyxoma Peritonei	3.3%
648	Seminoma	3.3%
649	Papillomatosis	3.3%
650	Angiolipoma	3.3%
651	Myelolipoma	3.3%
652	Neoplasms, Bone Tissue	3.3%
653	Neoplasms, Fibrous Tissue	3.3%
654	Smooth Muscle Tumor	3.3%
655	Adenomatosis, Pulmonary	3.3%
656	Adenomatous Polyps	3.3%
657	Carcinoma, Large Cell	3.3%
658	Carcinoma, Small Cell	3.3%
659	Desmoplastic Small Round Cell Tumor	3.3%
660	Chondroma	3.3%
661	Enchondroma	3.3%
662	Diverticulitis	3.3%
663	Dumping Syndrome	3.3%
664	Friedreich Ataxia	3.3%
665	Renal tubular acidosis	3.3%
666	granulosa cell tumor	3.3%
667	Carcinoma, Ovarian Epithelial	3.3%
668	Adrenocortical carcinoma	3.3%
669	Dermatomycoses	3.2%
670	Mucocutaneous Lymph Node Syndrome	3.2%
671	Skin Diseases, Bacterial	3.2%
672	Drug Eruptions	3.2%
673	Lipodystrophy	3.2%
674	Livedo Reticularis	3.2%
675	Malignant Atrophic Papulosis	3.2%
676	Polyarteritis Nodosa	3.2%
677	Takayasu Arteritis	3.2%
678	Palatal Neoplasms	3.1%
679	Erythema Chronicum Migrans	3.1%
680	CREST Syndrome	3.1%
681	Nose Neoplasms	3.1%
682	Hypokalemic periodic paralysis	3.1%
683	Cystinuria	3%
684	Myelitis, Transverse	3%
685	Familial Hypophosphatemic Rickets	3%
686	Urogenital Abnormalities	3%
687	Adenoid Cystic Carcinoma	3%
688	Esophageal Achalasia	3%
689	fibroma	3%
690	Fibromatosis	3%
691	Osteoblastoma	3%
692	Osteoma	3%
693	Rhabdomyoma	3%
694	Chondromatosis	3%
695	Adenocarcinoma, Clear Cell	3%
696	Cholangiocarcinoma	3%
697	Cervical Intraepithelial Neoplasia	3%
698	Hemangioblastoma	3%
699	Lymphoma, Extranodal NK-T-Cell	3%
700	Neonatal Abstinence Syndrome	2.9%
701	Maxillofacial Abnormalities	2.9%
702	Dural Arteriovenous Fistula	2.9%
703	Renal Cell Carcinoma	2.9%
704	Papillary Renal Cell Carcinoma	2.9%
705	Adrenal Gland Neoplasms	2.9%
706	Genital Neoplasms, Male	2.9%
707	Uveal Neoplasms	2.9%
708	Dextrocardia	2.9%
709	Liver Diseases, Parasitic	2.9%
710	Fetal Growth Retardation	2.9%
711	Urologic Neoplasms	2.9%
712	Nesidioblastosis	2.9%
713	Fetal Hypoxia	2.9%
714	Congenital nystagmus	2.9%
715	Fetal Alcohol Spectrum Disorders	2.9%
716	Collagen Diseases	2.9%
717	Mixed Connective Tissue Disease	2.9%
718	Mucinoses	2.9%
719	Diverticulum	2.8%
720	Spinal Neoplasms	2.8%
721	Bone Marrow Neoplasms	2.8%
722	Diverticulosis	2.8%
723	Toxoplasmosis, Congenital	2.8%
724	Syphilis, Congenital	2.8%
725	Hepatic Veno-Occlusive Disease	2.8%
726	Peliosis Hepatis	2.8%
727	Hepatopulmonary Syndrome	2.8%
728	Fatty Liver, Alcoholic	2.8%
729	Hepatitis, Alcoholic	2.8%
730	Liver Cirrhosis, Alcoholic	2.8%
731	Carcinoma, Endometrioid	2.8%
732	Hodgkin Disease	2.8%
733	Lymphoma, Non-Hodgkin	2.8%
734	Polycystic Ovary Syndrome	2.8%
735	Hemoperitoneum	2.8%
736	Hepatomegaly	2.8%
737	Peritonitis	2.8%
738	Peritoneal Fibrosis	2.8%
739	Encapsulating Peritoneal Sclerosis	2.8%
740	Fibromatosis, Aggressive	2.8%
741	Fibromatosis, Abdominal	2.8%
742	Klatskin Tumor	2.8%
743	Biliary Fistula	2.8%
744	Gastric Fistula	2.8%
745	Hepatic Vein Thrombosis	2.8%
746	Liver Abscess	2.8%
747	Budd-Chiari Syndrome	2.8%
748	Pituitary Adenoma	2.8%
749	Pituitary Neoplasms	2.8%
750	Meningeal Neoplasms	2.8%
751	Choledocholithiasis	2.8%
752	Hidradenitis Suppurativa	2.7%
753	Leukemia, Myelomonocytic, Chronic	2.7%
754	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.7%
755	Nasopharyngeal carcinoma	2.7%
756	Arthritis, Gouty	2.7%
757	Glycosuria, Renal	2.7%
758	Prune Belly Syndrome	2.7%
759	Twins, Conjoined	2.7%
760	Waardenburg Syndrome	2.7%
761	Chorioamnionitis	2.5%
762	Primary amyloidosis	2.5%
763	Lichen Planus	2.5%
764	Pityriasis Rosea	2.5%
765	Pityriasis Rubra Pilaris	2.5%
766	Lichen Nitidus	2.5%
767	Cartilage Diseases	2.5%
768	Rheumatism	2.5%
769	Chondromalacia	2.5%
770	Meningeal Carcinomatosis	2.5%
771	Mastocytosis, Systemic	2.5%
772	Diaper Rash	2.4%
773	Leukemia, Myeloid, Chronic-Phase	2.4%
774	Chemical and Drug Induced Liver Injury	2.4%
775	Ear Neoplasms	2.4%
776	Eyelid Neoplasms	2.4%
777	Lung Neoplasms	2.4%
778	Pleural Neoplasms	2.4%
779	Lupus Erythematosus, Systemic	2.4%
780	Overlap syndrome	2.4%
781	Hepatorenal Syndrome	2.4%
782	Sturge-Weber Syndrome	2.4%
783	Cell Transformation, Viral	2.4%
784	Scimitar Syndrome	2.4%
785	Brain Neoplasms	2.4%
786	Salivary Gland Neoplasms	2.4%
787	Spinal Cord Neoplasms	2.4%
788	Tongue Neoplasms	2.4%
789	Laryngomalacia	2.4%
790	Hemangioma, Cavernous	2.4%
791	Pectus carinatum	2.3%
792	Leukemia, T-Cell	2.3%
793	Uterine Neoplasms	2.3%
794	Vaginal Neoplasms	2.3%
795	Vulvar Neoplasms	2.3%
796	Uterine Cancer	2.3%
797	Leukemia, B-Cell	2.3%
798	Fallopian Tube Neoplasms	2.3%
799	neurofibroma	2.3%
800	Lymphoma, Follicular	2.3%
801	T-Cell Lymphoma	2.3%
802	Mantle cell lymphoma	2.3%
803	Acrocephalosyndactylia	2.3%
804	Microcephaly	2.3%
805	Macrocephaly	2.3%
806	MELAS Syndrome	2.2%
807	Anophthalmos	2.2%
808	Hydranencephaly	2.2%
809	Microphthalmos	2.2%
810	Neural Tube Defects	2.2%
811	Paralysis, Obstetric	2.2%
812	Retinopathy of Prematurity	2.2%
813	Tethered Cord Syndrome	2.2%
814	Iniencephaly	2.2%
815	Craniorachischisis	2.2%
816	Limb Deformities, Congenital	2.2%
817	Exencephaly	2.2%
818	Septo-Optic Dysplasia	2.2%
819	Craniofacial Abnormalities	2.2%
820	Cortical Dysplasia	2.2%
821	Malformations of Cortical Development	2.2%
822	Mycetoma	2.2%
823	Liver Abscess, Amebic	2.2%
824	Abnormalities, Radiation-Induced	2.2%
825	Bloom Syndrome	2.2%
826	ovarian neoplasm	2.2%
827	Bronchopulmonary Dysplasia	2.2%
828	Craniosynostosis	2.2%
829	Syndactyly	2.2%
830	Brachycephaly	2.2%
831	Tinea Pedis	2.2%
832	Bronchial Neoplasms	2.1%
833	Pharyngeal Neoplasms	2.1%
834	Multiple Pulmonary Nodules	2.1%
835	Supratentorial Neoplasms	2.1%
836	Endometrial Neoplasms	2.1%
837	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.1%
838	Leukemia, Large Granular Lymphocytic	2.1%
839	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.1%
840	Alopecia	2.1%
841	Sweating, Gustatory	2.1%
842	Androgenetic Alopecia	2.1%
843	Auriculotemporal Syndrome	2.1%
844	Lymphoma, T-Cell, Cutaneous	2.1%
845	Lymphoma, AIDS-Related	2.1%
846	Enteropathy-Associated T-Cell Lymphoma	2.1%
847	Primary Effusion Lymphoma	2.1%
848	Laryngopharyngeal Reflux	2.1%
849	Penile Neoplasms	2.1%
850	Prostatic Neoplasms	2.1%
851	Lice Infestations	2.1%
852	Varicose Ulcer	2.1%
853	Galactorrhea	2.1%
854	Polycythemia Vera	2%
855	Porencephaly	2%
856	Giant Cell Arteritis	2%
857	Temporal Arteritis	2%
858	Cholangitis	2%
859	Cholecystitis	2%
860	Cholestasis	2%
861	Common Bile Duct Diseases	2%
862	Hepatitis, Chronic	2%
863	Liver Failure	2%
864	Pancreatitis, Chronic	2%
865	Non-alcoholic Fatty Liver Disease	2%
866	Chronic active hepatitis	2%
867	Waldenstrom Macroglobulinemia	2%
868	Multiple Myeloma	2%
869	Brain Stem Neoplasms	2%
870	Ophthalmia Neonatorum	2%
871	Mycosis Fungoides	2%
872	Lymphomatoid Papulosis	2%
873	Plasmablastic lymphoma	2%
874	Cleft Palate	1.9%
875	Blepharophimosis	1.9%
876	Laryngostenosis	1.9%
877	Mouth Abnormalities	1.9%
878	Respiratory Distress Syndrome, Newborn	1.9%
879	Horseshoe Kidney	1.9%
880	Pectus excavatum	1.9%
881	Choroid Plexus Papilloma	1.9%
882	Klippel-Feil Syndrome	1.9%
883	Gastroschisis	1.9%
884	Synostosis	1.9%
885	Lymphangiectasis, Intestinal	1.9%
886	Laryngeal neoplasm	1.9%
887	Hypopharyngeal Neoplasms	1.9%
888	Pleural Effusion, Malignant	1.9%
889	Hypopharyngeal Cancer	1.9%
890	Parotid Neoplasms	1.8%
891	Prostatic Neoplasms, Castration-Resistant	1.8%
892	Jaw Abnormalities	1.8%
893	Nelson Syndrome	1.8%
894	Bladder Neoplasm	1.8%
895	Kidney Neoplasm	1.8%
896	Ureteral Neoplasms	1.8%
897	Urethral Neoplasms	1.8%
898	Poland Syndrome	1.8%
899	Larva Migrans	1.8%
900	Leishmaniasis	1.8%
901	Molluscum Contagiosum	1.8%
902	Angioedema	1.8%
903	Onchocerciasis	1.8%
904	Cellulitis	1.8%
905	Chromoblastomycosis	1.8%
906	Dermatophytosis	1.8%
907	Sporotrichosis	1.8%
908	Tinea	1.8%
909	Tinea Versicolor	1.8%
910	Trichophytosis	1.8%
911	Hyalohyphomycosis	1.8%
912	Acute Generalized Exanthematous Pustulosis	1.8%
913	Bronchomalacia	1.8%
914	Tracheomalacia	1.8%
915	Tonsillar Neoplasms	1.7%
916	Cerebellar Neoplasms	1.7%
917	Hepatitis, Animal	1.7%
918	Hepatitis, Viral, Human	1.7%
919	Arthrogryposis	1.7%
920	Choanal Atresia	1.7%
921	Tracheobronchomegaly	1.7%
922	Laryngocele	1.7%
923	Hermaphroditism	1.7%
924	Disorders of Sex Development	1.7%
925	Cryptorchidism	1.7%
926	Hypospadias	1.7%
927	Dandy-Walker Syndrome	1.7%
928	Liver Cirrhosis, Experimental	1.7%
929	Amelia	1.7%
930	Arachnodactyly	1.7%
931	Ectopia Cordis	1.7%
932	Ectromelia	1.7%
933	Hemimelia	1.7%
934	Meningomyelocele	1.7%
935	Phocomelia	1.7%
936	Sirenomelia	1.7%
937	Spina Bifida	1.7%
938	Polydactyly	1.7%
939	Brachydactyly	1.7%
940	Plagiocephaly	1.7%
941	Pancreatitis, Alcoholic	1.7%
942	Lower Extremity Deformities, Congenital	1.7%
943	Upper Extremity Deformities, Congenital	1.7%
944	Single umbilical artery	1.7%
945	Leukomalacia, Periventricular	1.6%
946	POEMS Syndrome	1.6%
947	Burkitt Lymphoma	1.6%
948	Warts	1.6%
949	Micrognathism	1.5%
950	Pierre Robin Syndrome	1.5%
951	Candidiasis, Chronic Mucocutaneous	1.5%
952	Cutaneous Candidiasis	1.5%
953	Erysipelas	1.5%
954	Serum Sickness	1.5%
955	Sezary Syndrome	1.5%
956	Staphylococcal Skin Infections	1.5%
957	Radicular Cyst	1.5%
958	Erythrasma	1.5%
959	Arthritis, Psoriatic	1.5%
960	Scleromyxedema	1.5%
961	Nasopharyngeal Neoplasms	1.5%
962	Bladder Exstrophy	1.5%
963	Epispadias	1.5%
964	Alopecia Areata	1.5%
965	Multicystic Dysplastic Kidney	1.5%
966	Fascioliasis	1.4%
967	Hepatitis B, Chronic	1.4%
968	Hepatitis C, Chronic	1.4%
969	Echinococcosis, Hepatic	1.4%
970	Chemical and Drug Induced Liver Injury, Chronic	1.4%
971	Aortic coarctation	1.4%
972	Cor Triatriatum	1.4%
973	Coronary Vessel Anomalies	1.4%
974	Dental Enamel Hypoplasia	1.4%
975	Patent ductus arteriosus	1.4%
976	Ebstein Anomaly	1.4%
977	Heart Septal Defects	1.4%
978	Hyaline Membrane Disease	1.4%
979	Hypodontia	1.4%
980	Macrostomia	1.4%
981	Meningocele	1.4%
982	Microstomia	1.4%
983	Reye Syndrome	1.4%
984	Tetralogy of Fallot	1.4%
985	Transposition of Great Vessels	1.4%
986	Hypoplastic Left Heart Syndrome	1.4%
987	May-Thurner Syndrome	1.4%
988	Encephalocele	1.4%
989	Retrognathia	1.4%
990	Craniofacial Dysostosis	1.4%
991	Wolff-Parkinson-White Syndrome	1.4%
992	Dermal Sinus	1.4%
993	Spina Bifida Cystica	1.4%
994	Spina Bifida Occulta	1.4%
995	Lissencephaly	1.4%
996	Polymicrogyria	1.4%
997	Pachygyria	1.4%
998	Schizencephaly	1.4%
999	Periventricular Nodular Heterotopia	1.4%
1000	Paranasal Sinus Neoplasms	1.4%
1001	Hyperandrogenism	1.3%
1002	Kernicterus	1.3%
1003	Cholestasis, Extrahepatic	1.3%
1004	Biliary Dyskinesia	1.3%
1005	Cholangitis, Sclerosing	1.3%
1006	Liver Failure, Acute	1.3%
1007	Acalculous Cholecystitis	1.3%
1008	End Stage Liver Disease	1.3%
1009	Prognathism	1.3%
1010	Tietze's Syndrome	1.3%
1011	Orbital Cellulitis	1.3%
1012	Maxillary Sinus Neoplasms	1.3%
1013	Lichen Planus, Oral	1.2%
1014	Myxedema	1.2%
1015	Long QT Syndrome	1.2%
1016	Platybasia	1.2%
1017	Tricuspid Atresia	1.2%
1018	Arrhythmogenic Right Ventricular Dysplasia	1.2%
1019	Blastomycosis	1.2%
1020	Gonadal Dysgenesis	1.2%
1021	Adrenogenital Syndrome	1.2%
1022	Ovotesticular Disorders of Sex Development	1.2%
1023	HIV-Associated Lipodystrophy Syndrome	1.2%
1024	Aortopulmonary Septal Defect	1.2%
1025	Double Outlet Right Ventricle	1.2%
1026	Endocardial Cushion Defects	1.2%
1027	Myocardial bridging	1.2%
1028	Aorticopulmonary Septal Defect	1.2%
1029	Rhinoscleroma	1.1%
1030	Autoimmune hepatitis	1.1%
1031	Osteochondritis	1.1%
1032	Polymyalgia Rheumatica	1.1%
1033	Keloid	1.1%
1034	Leishmaniasis, Cutaneous	1.1%
1035	Eczema Herpeticum	1.1%
1036	Fusariosis	1%
1037	Truncus Arteriosus, Persistent	1%
1038	Goldenhar Syndrome	1%
1039	Mandibulofacial Dysostosis	1%
1040	Romano-Ward Syndrome	1%
1041	Massive Hepatic Necrosis	1%
1042	Emphysematous Cholecystitis	1%
1043	Sphincter of Oddi Dysfunction	1%
1044	Hepatitis, Viral, Animal	1%
1045	Hepatitis E	1%
1046	Hepatitis B	1%
1047	Hepatitis C	1%
1048	Rheumatoid Arthritis	1%
1049	Juvenile arthritis	1%
1050	Hepatitis A	0.9%
1051	Hepatic Encephalopathy	0.9%
1052	Epidermodysplasia Verruciformis	0.9%
1053	Herpes Labialis	0.9%
1054	Lupus Nephritis	0.9%
1055	Talipes	0.9%
1056	Diabetic Foot	0.9%
1057	Staphylococcal Scalded Skin Syndrome	0.9%
1058	Congenital clubfoot	0.9%
1059	Vertical Talus	0.9%
1060	Condylomata Acuminata	0.8%
1061	Furunculosis	0.8%
1062	furuncle	0.8%
1063	Arteriovenous fistula	0.8%
1064	Impetigo	0.8%
1065	Hereditary Angioedema Type III	0.7%
1066	Hereditary Angioedema Types I and II	0.7%
1067	carbuncle	0.6%
1068	Rheumatoid Nodule	0.6%
1069	Felty Syndrome	0.5%
1070	Rift Valley Fever	0.5%
1071	Lupus Vasculitis, Central Nervous System	0.5%
1072	Rheumatoid Vasculitis	0.5%
1073	Sicca Syndrome	0.4%
1074	Sjogren's Syndrome	0.4%

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