MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple Endocrine Neoplasia

(UMLS:C0027662)

Definition:: A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
UMLS ID:: C0027662
MeSH ID:: D009377

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.322.400|C04.651.600|C04.700.630

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.700.630

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.344.400

Synonym(s)

Multiple Endocrine Neoplasia

Adenomatosis, Familial endocrine

Endocrine adenomatosis

Familial polyendocrine adenomatosis

MEA - Multiple endocrine adenomatosis

MEA SYNDROME

MEN - Multiple endocrine neoplasia

MEN Syndromes

MEN syndrome

10.

Multiple Endocrine Adenomatosis

11.

Multiple Endocrine Adenomatosis NOS

12.

Multiple Endocrine Neoplasia Syndrome

13.

Multiple Endocrine Neoplasia Syndrome(s)

14.

Multiple endocrine adenomas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 2		US FAERS
2	Sitagliptin Phosphate	FAERS: 2		US FAERS
3	Cimetidine		420338	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Parathyroid Neoplasms	36.9%
2	Thyroid Neoplasm	36.9%
3	Thyroid carcinoma	36.9%
4	Tuberous Sclerosis	34.4%
5	Adrenal Gland Neoplasms	31.3%
6	Pancreatic Neoplasm	30.6%
7	Thyroid Nodule	27.8%
8	Testicular Neoplasms	27.6%
9	Nephroblastoma	25.4%
10	Carcinoma, Pancreatic Ductal	25.1%
11	Basal Cell Nevus Syndrome	25%
12	Peutz-Jeghers Syndrome	24.9%
13	ovarian neoplasm	23.8%
14	Prolactinoma	22.8%
15	Growth Hormone-Secreting Pituitary Adenoma	22.8%
16	Pituitary Adenoma	22.3%
17	Pituitary Neoplasms	22.3%
18	Adenomatous Polyposis Coli	22%
19	Vipoma	21.9%
20	Adrenocortical carcinoma	21%
21	insulinoma	21%
22	Gastrinoma	20.7%
23	Glucagonoma	20.7%
24	granulosa cell tumor	20.3%
25	Carcinoma, Ovarian Epithelial	20.3%
26	Hamartoma	20.2%
27	Neoplasms, Hormone-Dependent	20.2%
28	Paraneoplastic Syndromes	20.2%
29	Precancerous Conditions	20.2%
30	Neoplasms, Second Primary	20.2%
31	Paraneoplastic Encephalomyelitis	20%
32	Leydig Cell Tumor	20%
33	Carcinoma 256, Walker	19.8%
34	Abdominal Neoplasms	19.8%
35	Head and Neck Neoplasms	19.8%
36	Soft Tissue Neoplasms	19.8%
37	Thoracic Neoplasms	19.8%
38	Medulloblastoma	19.8%
39	Mammary Neoplasms, Experimental	19.7%
40	Melanoma, Experimental	19%
41	Peritoneal Neoplasms	18.5%
42	Meningioma	18.2%
43	Carcinoma, Lobular	18.1%
44	Acanthoma	18%
45	Neoplasms, Neuroepithelial	17.8%
46	Gliomatosis cerebri	17.8%
47	Cyst	17.3%
48	Digestive System Neoplasms	17.3%
49	Eye Neoplasms	17.3%
50	Neoplastic Processes	17.3%
51	Nervous System Neoplasms	17.3%
52	Pregnancy Complications, Neoplastic	17.3%
53	Nelson Syndrome	17.3%
54	Carcinoma, Ehrlich Tumor	17.2%
55	Dermoid Cyst	17.2%
56	Carcinoma, Lewis Lung	17.2%
57	Neoplasms, Experimental	17.2%
58	Bone neoplasms	17%
59	Skin Neoplasms	17%
60	Hematologic Neoplasms	17%
61	Splenic Neoplasms	16.8%
62	Tracheal Neoplasms	16.5%
63	melanoma	16.5%
64	Trophoblastic Neoplasms	16.4%
65	Denys-Drash Syndrome	16.3%
66	Leukemia, Experimental	16.3%
67	Acoustic Neuroma	16.1%
68	Neuroectodermal Tumors	15.7%
69	Retinoblastoma	15.4%
70	Choriocarcinoma	15.1%
71	Adenoma, Acidophil	15.1%
72	Ganglioneuroma	15.1%
73	Glioma	15.1%
74	Malignant Glioma	15.1%
75	Neoplasms, Radiation-Induced	15%
76	Sarcoma, Experimental	15%
77	Thymoma	14.9%
78	Esophageal Neoplasms	14.6%
79	Leukemia, Radiation-Induced	14.6%
80	Carcinoid Tumor	14.5%
81	Neurilemmoma	14.5%
82	Hutchinson's Melanotic Freckle	14.5%
83	Melanoma, Amelanotic	14.5%
84	Optic Nerve Glioma	14.2%
85	Carcinosarcoma	14.1%
86	Hemangiosarcoma	14.1%
87	Leukemia L1210	14.1%
88	Leukemia P388	14.1%
89	lymphangiosarcoma	14.1%
90	Liver Neoplasms, Experimental	13.9%
91	Multiple Endocrine Neoplasia	13.9%
92	Astrocytoma	13.8%
93	Ependymoma	13.8%
94	oligodendroglioma	13.8%
95	Ganglioglioma	13.8%
96	gliosarcoma	13.8%
97	Anaplastic astrocytoma	13.8%
98	Anaplastic Oligodendroglioma	13.8%
99	Retroperitoneal Neoplasms	13.8%
100	Malignant Carcinoid Syndrome	13.5%
101	Sarcoma 180	13.4%
102	Dwarfism	13.3%
103	Leukoplakia, Oral	13.2%
104	Paraneoplastic Cerebellar Degeneration	13.2%
105	Glioblastoma	13.2%
106	Neuroblastoma	13.2%
107	Glioblastoma Multiforme	13.2%
108	Neoplasms, Multiple Primary	13.1%
109	Ganglioneuroblastoma	12.8%
110	Erythroplasia	12.8%
111	Follicular cyst	12.8%
112	leukemia	12.8%
113	Mucocele	12.8%
114	Neoplasms, Germ Cell and Embryonal	12.8%
115	Neoplasms, Glandular and Epithelial	12.8%
116	Pilonidal Cyst	12.8%
117	Thyroglossal Cyst	12.8%
118	Synovial Cyst	12.8%
119	Germ Cell Cancer	12.8%
120	Aberrant Crypt Foci	12.8%
121	Basal cell carcinoma	12.6%
122	Carcinoma, Papillary	12.6%
123	Squamous cell carcinoma	12.6%
124	Chondrosarcoma	12.6%
125	Craniopharyngioma	12.6%
126	Cystadenoma	12.6%
127	leiomyosarcoma	12.6%
128	liposarcoma	12.6%
129	Mesothelioma	12.6%
130	synovial sarcoma	12.6%
131	Neuroectodermal Tumor, Melanotic	12.6%
132	Angiomyolipoma	12.6%
133	Clear Cell Sarcoma of Soft Tissue	12.6%
134	Alveolar Soft Part Sarcoma	12.6%
135	Neuroendocrine Tumors	12.6%
136	Sarcoma, Myeloid	12.6%
137	Carcinoma, Basal Cell	12.6%
138	Lymphomatoid Granulomatosis	12.5%
139	Leukemia, Plasma Cell	12.3%
140	Hepatocellular Adenoma	12%
141	Composite Lymphoma	12%
142	Corpus Luteum Cyst	12%
143	Ovarian Cysts	12%
144	Mouth Neoplasms	11.9%
145	Central Nervous System Neoplasms	11.9%
146	Vascular Neoplasms	11.9%
147	Thymus Neoplasms	11.9%
148	Cystadenocarcinoma	11.9%
149	Fibrosarcoma	11.9%
150	Osteosarcoma	11.9%
151	Mucoepidermoid Carcinoma	11.9%
152	Limbic Encephalitis	11.8%
153	Genital Neoplasms, Female	11.8%
154	Breast Neoplasms, Male	11.7%
155	Triple Negative Breast Neoplasms	11.7%
156	Carcinoid Heart Disease	11.6%
157	Adenofibroma	11.5%
158	Fibroadenoma	11.5%
159	Malignant Fibrous Histiocytoma	11.5%
160	Neoplastic Syndromes, Hereditary	11.2%
161	Neurofibrosarcoma	11.2%
162	Bowen's Disease	11.1%
163	Paraganglioma	11.1%
164	Rhabdomyosarcoma	11.1%
165	Giant Cell Tumor of Bone	11.1%
166	Leukoplakia	11%
167	Lymphocele	11%
168	Pancreatic Cyst	11%
169	Barrett Esophagus	10.9%
170	Breast Cyst	10.9%
171	Histiocytic Disorders, Malignant	10.9%
172	Actinic keratosis	10.9%
173	Mediastinal Cyst	10.9%
174	Neoplasm Invasiveness	10.9%
175	Neoplasm Metastasis	10.9%
176	Neoplasm Recurrence, Local	10.9%
177	Parovarian Cyst	10.9%
178	Pericardial Cyst	10.9%
179	Thymic Cyst	10.9%
180	Carcinogenesis	10.9%
181	Myxoid cyst	10.9%
182	Metastasis	10.9%
183	Nose Neoplasms	10.9%
184	Lambert-Eaton Myasthenic Syndrome	10.8%
185	Palatal Neoplasms	10.8%
186	Dermatofibrosarcoma	10.7%
187	Dermatofibrosarcoma Protuberans	10.7%
188	Gastrointestinal Neoplasms	10.4%
189	Genital Neoplasms, Male	10.4%
190	Liver neoplasms	10.4%
191	Uveal Neoplasms	10.4%
192	Pheochromocytoma	10.4%
193	Alveolar rhabdomyosarcoma	10.4%
194	Urologic Neoplasms	10.3%
195	Hydatidiform Mole	10.3%
196	Aicardi's syndrome	10.3%
197	Sebaceous Gland Neoplasms	10.3%
198	Spinal Neoplasms	10.3%
199	Bone Marrow Neoplasms	10.3%
200	Endometrial Stromal Sarcoma	10.2%
201	Multiple Endocrine Neoplasia Type 1	10.1%
202	Fragile X Syndrome	10%
203	Choledochal Cyst	10%
204	Xeroderma Pigmentosum	9.9%
205	Opsoclonus-Myoclonus Syndrome	9.9%
206	Mesoblastic Nephroma	9.8%
207	Lymphangioleiomyomatosis	9.7%
208	Kallmann Syndrome	9.6%
209	Ichthyosis, X-Linked	9.5%
210	Carcinoma, Endometrioid	9.5%
211	Lymphoma	9.5%
212	CHARGE Syndrome	9.5%
213	Cystic Fibrosis	9.4%
214	Albinism	9.3%
215	Meningeal Neoplasms	9.3%
216	Adenoma	9.2%
217	Ameloblastoma	9.2%
218	Angiokeratoma	9.2%
219	Carcinoma	9.2%
220	Chordoma	9.2%
221	Hemangioma	9.2%
222	hemangiopericytoma	9.2%
223	Lymphangioma	9.2%
224	Mesenchymoma	9.2%
225	Nevus	9.2%
226	Teratoma	9.2%
227	Hepatoblastoma	9.2%
228	Mixed Tumor, Mullerian	9.2%
229	Germinoma	9.2%
230	Teratocarcinoma	9.2%
231	Angiofibroma	9.2%
232	Sarcoma	9.2%
233	Epithelioma	9.2%
234	Anemia, Sickle Cell	9%
235	Thalassemia	9%
236	Myelitis, Transverse	9%
237	Muscular Dystrophy, Duchenne	9%
238	Multiple Epiphyseal Dysplasia	8.9%
239	Osteochondrodysplasias	8.9%
240	Pelger-Huet Anomaly	8.9%
241	Werner Syndrome	8.9%
242	Myasthenic Syndromes, Congenital	8.9%
243	Congenital Hypothyroidism	8.9%
244	Polycystic Ovary Syndrome	8.9%
245	Central Nervous System Cysts	8.7%
246	Cockayne Syndrome	8.6%
247	Alstrom Syndrome	8.6%
248	Beckwith-Wiedemann Syndrome	8.5%
249	Wolf-Hirschhorn Syndrome	8.5%
250	Nail-Patella Syndrome	8.5%
251	Renal Cell Carcinoma	8.4%
252	Papillary Renal Cell Carcinoma	8.4%
253	Mucopolysaccharidosis II	8.4%
254	Ear Neoplasms	8.2%
255	Eyelid Neoplasms	8.2%
256	Lung Neoplasms	8.2%
257	Pleural Neoplasms	8.2%
258	Endocrine Gland Neoplasms	8.2%
259	Brain Neoplasms	8.1%
260	Salivary Gland Neoplasms	8.1%
261	Spinal Cord Neoplasms	8.1%
262	Tongue Neoplasms	8.1%
263	Uterine Neoplasms	8%
264	Vaginal Neoplasms	8%
265	Vulvar Neoplasms	8%
266	Uterine Cancer	8%
267	Fallopian Tube Neoplasms	8%
268	Meningeal Carcinomatosis	8%
269	Menkes Kinky Hair Syndrome	7.9%
270	Pancreatic Pseudocyst	7.8%
271	Plasmacytoma	7.8%
272	Nasopharyngeal carcinoma	7.8%
273	Malignant histiocytosis	7.8%
274	Lymphatic Metastasis	7.8%
275	Neoplasms, Unknown Primary	7.8%
276	Leukemic Infiltration	7.8%
277	Histiocytic sarcoma	7.8%
278	Neoplasm Micrometastasis	7.8%
279	Kartagener Syndrome	7.8%
280	Muscular Dystrophy	7.7%
281	Osteogenesis Imperfecta	7.7%
282	Adrenoleukodystrophy	7.7%
283	Smith-Magenis syndrome	7.6%
284	Rett Syndrome	7.6%
285	Cri-du-Chat Syndrome	7.5%
286	Down Syndrome	7.5%
287	Trisomy 21	7.5%
288	Adenocarcinoma	7.4%
289	Carcinoma in Situ	7.4%
290	Carcinoma, Transitional Cell	7.4%
291	Phyllodes Tumor	7.4%
292	Dysgerminoma	7.4%
293	Hemangioendothelioma	7.4%
294	Lipoma	7.4%
295	Myoma	7.4%
296	Myxoma	7.4%
297	Neuroma	7.4%
298	Papilloma	7.4%
299	Pseudomyxoma Peritonei	7.4%
300	Seminoma	7.4%
301	Papillomatosis	7.4%
302	Angiolipoma	7.4%
303	Myelolipoma	7.4%
304	Neoplasms, Bone Tissue	7.4%
305	Neoplasms, Fibrous Tissue	7.4%
306	Smooth Muscle Tumor	7.4%
307	Adenomatosis, Pulmonary	7.4%
308	Adenomatous Polyps	7.4%
309	Carcinoma, Large Cell	7.4%
310	Carcinoma, Small Cell	7.4%
311	Desmoplastic Small Round Cell Tumor	7.4%
312	Chondroma	7.4%
313	Enchondroma	7.4%
314	Wiskott-Aldrich Syndrome	7.4%
315	Pharyngeal Neoplasms	7.3%
316	Holoprosencephaly	7.3%
317	Bile Duct Neoplasms	7.2%
318	gallbladder neoplasm	7.2%
319	Intestinal Neoplasms	7.2%
320	Penile Neoplasms	7.2%
321	Prostatic Neoplasms	7.2%
322	Stomach Neoplasms	7.2%
323	Adrenal Gland Diseases	7.1%
324	Gonadal Disorders	7.1%
325	Parathyroid Diseases	7.1%
326	Thyroid Diseases	7.1%
327	Marfan Syndrome	7.1%
328	Polycythemia Vera	7.1%
329	Bronchial Neoplasms	7.1%
330	Multiple Pulmonary Nodules	7%
331	Supratentorial Neoplasms	6.9%
332	Autoimmune Lymphoproliferative Syndrome	6.9%
333	Endometrial Neoplasms	6.9%
334	Familial Mediterranean Fever	6.9%
335	Ectodermal Dysplasia	6.8%
336	Aplasia Cutis Congenita	6.8%
337	Angioedemas, Hereditary	6.8%
338	Hodgkin Disease	6.8%
339	Lymphoma, Non-Hodgkin	6.8%
340	Prader-Willi Syndrome	6.8%
341	Myotonic Dystrophy	6.7%
342	Sickle Cell Trait	6.7%
343	Smith-Lemli-Opitz Syndrome	6.7%
344	Laryngeal neoplasm	6.6%
345	Adenoid Cystic Carcinoma	6.6%
346	fibroma	6.6%
347	Fibromatosis	6.6%
348	Osteoblastoma	6.6%
349	Osteoma	6.6%
350	Rhabdomyoma	6.6%
351	Chondromatosis	6.6%
352	Adenocarcinoma, Clear Cell	6.6%
353	Cholangiocarcinoma	6.6%
354	Cervical Intraepithelial Neoplasia	6.6%
355	Hemangioblastoma	6.6%
356	Lymphoma, Extranodal NK-T-Cell	6.6%
357	Neuronal Ceroid-Lipofuscinoses	6.5%
358	Klinefelter Syndrome	6.5%
359	Rubinstein-Taybi Syndrome	6.4%
360	Bladder Neoplasm	6.4%
361	Kidney Neoplasm	6.4%
362	Ureteral Neoplasms	6.4%
363	Urethral Neoplasms	6.4%
364	Brain Stem Neoplasms	6.4%
365	Leukemia, Myelomonocytic, Chronic	6.3%
366	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.3%
367	Sjogren-Larsson Syndrome	6.3%
368	Hepatolenticular Degeneration	6.3%
369	Hypopharyngeal Neoplasms	6.2%
370	Pleural Effusion, Malignant	6.2%
371	Hypopharyngeal Cancer	6.2%
372	Refsum Disease	6.2%
373	Fabry Disease	6.2%
374	Parotid Neoplasms	6.1%
375	Prostatic Neoplasms, Castration-Resistant	6.1%
376	Bone Diseases, Endocrine	6.1%
377	Fibromatosis, Aggressive	6.1%
378	Fibromatosis, Abdominal	6.1%
379	Klatskin Tumor	6.1%
380	Choroid Plexus Papilloma	6.1%
381	Diabetes Mellitus	6.1%
382	Primary amyloidosis	6%
383	Pituitary Diseases	6%
384	Polycystic Kidney Diseases	6%
385	Williams Syndrome	6%
386	Deformity	6%
387	Primary Ciliary Dyskinesia	5.9%
388	Amino Acid Metabolism, Inborn Errors	5.9%
389	Carbohydrate Metabolism, Inborn Errors	5.9%
390	Metal Metabolism, Inborn Errors	5.9%
391	Progeria	5.9%
392	Lysosomal Storage Diseases	5.9%
393	Cytochrome-c Oxidase Deficiency	5.9%
394	Peroxisomal Disorders	5.9%
395	Amyloid Neuropathies, Familial	5.8%
396	Glycogen storage disease type II	5.7%
397	Tonsillar Neoplasms	5.7%
398	Cerebellar Neoplasms	5.7%
399	Mastocytoma	5.6%
400	Mastocytosis	5.6%
401	Sturge-Weber Syndrome	5.6%
402	Mastocytosis, Systemic	5.6%
403	Leukemia, Myeloid, Chronic-Phase	5.6%
404	Retinal Dysplasia	5.6%
405	Cell Transformation, Viral	5.5%
406	Acute Chest Syndrome	5.5%
407	Gastrointestinal Stromal Tumors	5.5%
408	Aniridia	5.5%
409	Cecal Neoplasms	5.5%
410	Duodenal Neoplasms	5.5%
411	Hemangioma, Cavernous	5.5%
412	Leukemia, T-Cell	5.5%
413	Leukemia, B-Cell	5.5%
414	neurofibroma	5.5%
415	Lymphoma, Follicular	5.5%
416	T-Cell Lymphoma	5.5%
417	Mantle cell lymphoma	5.5%
418	Galactosemias	5.4%
419	Urea Cycle Disorders, Inborn	5.4%
420	Tyrosinemias	5.4%
421	Epidermolysis Bullosa	5.4%
422	Cutis Laxa	5.2%
423	Retinitis Pigmentosa	5.2%
424	Pigmentary retinopathy	5.2%
425	Porokeratosis	5.1%
426	Keratoderma, Palmoplantar	5.1%
427	Ataxia Telangiectasia	5.1%
428	Turner Syndrome	5.1%
429	Chronic granulomatous disease	5.1%
430	Fetal Diseases	5.1%
431	Welander Distal Myopathy	5.1%
432	Nasopharyngeal Neoplasms	5.1%
433	Appendiceal Neoplasms	5.1%
434	Colonic Neoplasms	5.1%
435	Rectal Neoplasms	5.1%
436	Optic Atrophy, Hereditary, Leber	5%
437	Colorectal Neoplasms	5%
438	Mucopolysaccharidosis III	5%
439	Hyperphosphaturia	5%
440	Canavan Disease	5%
441	Alexander Disease	5%
442	Waldenstrom Macroglobulinemia	4.9%
443	Multiple Myeloma	4.9%
444	Zellweger Syndrome	4.9%
445	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
446	Leukemia, Large Granular Lymphocytic	4.8%
447	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
448	Lymphoma, T-Cell, Cutaneous	4.8%
449	Lymphoma, AIDS-Related	4.8%
450	Enteropathy-Associated T-Cell Lymphoma	4.8%
451	Primary Effusion Lymphoma	4.8%
452	Gaucher Disease	4.7%
453	Adrenal Cortex Diseases	4.7%
454	Euthyroid Sick Syndromes	4.7%
455	Goiter	4.7%
456	Hyperparathyroidism	4.7%
457	Hyperthyroidism	4.7%
458	Hyperthyroxinemia	4.7%
459	Hypogonadism	4.7%
460	Hypoparathyroidism	4.7%
461	Hypothyroidism	4.7%
462	Delayed Puberty	4.7%
463	Precocious Puberty	4.7%
464	Thyroiditis	4.7%
465	Hypogonadotropic hypogonadism	4.7%
466	Testotoxicosis	4.7%
467	Secondary hypothyroidism	4.7%
468	Primary Hyperthyroidism	4.7%
469	Primary Hypothyroidism	4.7%
470	Paranasal Sinus Neoplasms	4.6%
471	Duane Retraction Syndrome	4.6%
472	Hermaphroditism	4.6%
473	Disorders of Sex Development	4.6%
474	Dupuytren Contracture	4.6%
475	Homocystinuria	4.6%
476	Graves Disease	4.6%
477	Porphyrias, Hepatic	4.6%
478	Classical Lissencephalies and Subcortical Band Heterotopias	4.6%
479	Leigh Disease	4.6%
480	Urticaria Pigmentosa	4.5%
481	Pseudoxanthoma Elasticum	4.5%
482	Myotonia Congenita	4.5%
483	Thrombasthenia	4.5%
484	Antithrombin III Deficiency	4.5%
485	Protein C Deficiency	4.5%
486	Brain Diseases, Metabolic, Inborn	4.5%
487	Afibrinogenemia	4.5%
488	Dystonia Musculorum Deformans	4.5%
489	Factor VII Deficiency	4.5%
490	Factor X Deficiency	4.5%
491	Factor XII Deficiency	4.5%
492	Hemophilia A	4.5%
493	Activated Protein C Resistance	4.5%
494	Factor II deficiency	4.5%
495	Factor VIII Deficiency	4.5%
496	Factor V deficiency	4.5%
497	Factor XI Deficiency	4.5%
498	Hypoprothrombinemias	4.5%
499	Fanconi Anemia	4.5%
500	Mycosis Fungoides	4.5%
501	Lymphomatoid Papulosis	4.5%
502	Plasmablastic lymphoma	4.5%
503	Zollinger-Ellison syndrome	4.5%
504	Lafora Disease	4.5%
505	Unverricht-Lundborg Syndrome	4.5%
506	Anemia, Diamond-Blackfan	4.5%
507	Polycystic Kidney, Autosomal Dominant	4.5%
508	Hyperkeratosis, Epidermolytic	4.4%
509	Anus Neoplasms	4.4%
510	Sigmoid Neoplasms	4.4%
511	Alkaptonuria	4.4%
512	Glycogen Storage Disease	4.4%
513	Hypophosphatasia	4.4%
514	Propionic acidemia	4.4%
515	Dihydropyrimidine Dehydrogenase Deficiency	4.4%
516	Cystinosis	4.4%
517	Tay-Sachs Disease	4.3%
518	Maxillary Sinus Neoplasms	4.2%
519	Meconium Aspiration Syndrome	4.2%
520	Niemann-Pick Disease, Type C	4.1%
521	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.1%
522	Dermatitis, Atopic	4.1%
523	Charcot-Marie-Tooth Disease	4%
524	Antley-Bixler Syndrome Phenotype	4%
525	Testicular Diseases	4%
526	Ovarian Diseases	3.9%
527	Empty Sella Syndrome	3.9%
528	Hyperpituitarism	3.9%
529	Hypopituitarism	3.9%
530	Hypophysitis	3.9%
531	Burkitt Lymphoma	3.8%
532	Cryptorchidism	3.8%
533	Xeroderma	3.8%
534	Mobius Syndrome	3.8%
535	Hyperandrogenism	3.8%
536	Hypolipoproteinemias	3.8%
537	Papillon-Lefevre Disease	3.8%
538	Hyperlipidemia, Familial Combined	3.8%
539	Hyperlipoproteinemia Type III	3.8%
540	Diabetic Foot	3.7%
541	Behcet Syndrome	3.7%
542	Glycogen Storage Disease Type I	3.6%
543	Glycogen Storage Disease Type V	3.6%
544	Sezary Syndrome	3.6%
545	Radicular Cyst	3.6%
546	Abdominal Cramps	3.5%
547	Abnormalities, Drug-Induced	3.5%
548	Amniotic Band Syndrome	3.5%
549	Asphyxia Neonatorum	3.5%
550	Infant, Premature, Diseases	3.5%
551	Situs Inversus	3.5%
552	Infantile Colic	3.5%
553	Gestational Diabetes	3.5%
554	Latent Autoimmune Diabetes in Adults	3.5%
555	Cushing Syndrome	3.4%
556	Hyperaldosteronism	3.4%
557	Hyperparathyroidism, Secondary	3.4%
558	Hypoaldosteronism	3.4%
559	Thyrotoxicosis	3.4%
560	Hyperparathyroidism, Primary	3.4%
561	Thyroid Hormone Resistance Syndrome	3.4%
562	Diabetes Insipidus	3.4%
563	Diabetes Mellitus, Experimental	3.4%
564	Familial Periodic Paralysis	3.4%
565	Gonadal Dysgenesis	3.4%
566	Adrenogenital Syndrome	3.4%
567	Ovotesticular Disorders of Sex Development	3.4%
568	Lactose Intolerance	3.4%
569	Variegate Porphyria	3.4%
570	Acute intermittent porphyria	3.4%
571	Porphyria Cutanea Tarda	3.4%
572	Hyperhomocysteinemia	3.4%
573	Huntington Disease	3.4%
574	Renal Aminoacidurias	3.4%
575	Fanconi Syndrome	3.4%
576	Pseudohypoaldosteronism	3.4%
577	Liddle Syndrome	3.4%
578	Hyperlipoproteinemia Type IV	3.3%
579	Hyperlipoproteinemia Type V	3.3%
580	Hydrops Fetalis	3.2%
581	Hypoalphalipoproteinemias	3.1%
582	Eye Abnormalities	3.1%
583	Gout	3.1%
584	Cardiovascular Abnormalities	3.1%
585	Pseudohypoparathyroidism	3%
586	Friedreich Ataxia	3%
587	Pituitary Apoplexy	3%
588	Renal tubular acidosis	3%
589	Skin Abnormalities	3%
590	Lymphatic Abnormalities	3%
591	Congenital Microtia	3%
592	Anencephaly	3%
593	Addison Disease	3%
594	Anemia, Neonatal	3%
595	Diabetic Angiopathies	3%
596	Persistent Fetal Circulation Syndrome	3%
597	Autoimmune thyroiditis	3%
598	Primary Adrenal Insufficiency	3%
599	Congenital diaphragmatic hernia	3%
600	Umbilical hernia	2.9%
601	Diabetic Neuropathies	2.9%
602	Myxedema	2.9%
603	Orchitis	2.9%
604	Diabetic Amyotrophy	2.9%
605	Diabetic Autonomic Neuropathy	2.9%
606	Diabetic Cardiomyopathies	2.9%
607	Ovarian Hyperstimulation Syndrome	2.9%
608	Hyperprolactinemia	2.9%
609	Familial Hypophosphatemic Rickets	2.9%
610	Hyperglycemic Hyperosmolar Nonketotic Coma	2.9%
611	Hashimoto Disease	2.9%
612	Hypokalemic periodic paralysis	2.8%
613	Cystinuria	2.8%
614	Urogenital Abnormalities	2.7%
615	Maxillofacial Abnormalities	2.7%
616	Dural Arteriovenous Fistula	2.7%
617	Dextrocardia	2.6%
618	Neonatal Abstinence Syndrome	2.6%
619	Fetal Growth Retardation	2.6%
620	Fetal Hypoxia	2.6%
621	Congenital nystagmus	2.6%
622	Fetal Alcohol Spectrum Disorders	2.6%
623	Gigantism	2.6%
624	Toxoplasmosis, Congenital	2.6%
625	Diabetic Nephropathy	2.6%
626	Syphilis, Congenital	2.6%
627	Acromegaly	2.5%
628	Anovulation	2.5%
629	Diabetic Ketoacidosis	2.5%
630	Oophoritis	2.5%
631	Arthritis, Gouty	2.5%
632	Glycosuria, Renal	2.5%
633	Prune Belly Syndrome	2.3%
634	Twins, Conjoined	2.3%
635	Waardenburg Syndrome	2.3%
636	Congenital Hyperinsulinism	2.3%
637	Chorioamnionitis	2.3%
638	Scimitar Syndrome	2.2%
639	Acrocephalosyndactylia	2.2%
640	Diabetic Retinopathy	2.1%
641	MELAS Syndrome	2.1%
642	Microcephaly	2.1%
643	Macrocephaly	2.1%
644	Abnormalities, Radiation-Induced	2%
645	Craniosynostosis	2%
646	Syndactyly	2%
647	Brachycephaly	2%
648	Anophthalmos	2%
649	Anus, Imperforate	2%
650	Hydranencephaly	2%
651	Microphthalmos	2%
652	Neural Tube Defects	2%
653	Paralysis, Obstetric	2%
654	Retinopathy of Prematurity	2%
655	Tethered Cord Syndrome	2%
656	Iniencephaly	2%
657	Craniorachischisis	2%
658	Limb Deformities, Congenital	2%
659	Exencephaly	2%
660	Septo-Optic Dysplasia	2%
661	Craniofacial Abnormalities	2%
662	Cortical Dysplasia	2%
663	Malformations of Cortical Development	2%
664	Anorectal Malformations	2%
665	Bloom Syndrome	2%
666	Bronchopulmonary Dysplasia	2%
667	Porencephaly	1.9%
668	Noonan Syndrome	1.9%
669	Cleft Palate	1.8%
670	Ophthalmia Neonatorum	1.8%
671	Blepharophimosis	1.7%
672	Laryngostenosis	1.7%
673	Mouth Abnormalities	1.7%
674	Respiratory Distress Syndrome, Newborn	1.7%
675	Esophageal Atresia	1.7%
676	Intestinal Atresia	1.7%
677	Horseshoe Kidney	1.7%
678	Pectus excavatum	1.7%
679	Klippel-Feil Syndrome	1.7%
680	Gastroschisis	1.7%
681	Synostosis	1.7%
682	Acrodermatitis	1.7%
683	Lymphangiectasis, Intestinal	1.7%
684	Gianotti-Crosti Syndrome	1.7%
685	Jaw Abnormalities	1.7%
686	Poland Syndrome	1.7%
687	Arthrogryposis	1.6%
688	Choanal Atresia	1.6%
689	Tracheobronchomegaly	1.6%
690	Laryngocele	1.6%
691	Hypospadias	1.5%
692	Dandy-Walker Syndrome	1.5%
693	Leukomalacia, Periventricular	1.5%
694	POEMS Syndrome	1.5%
695	Nesidioblastosis	1.5%
696	Amelia	1.5%
697	Arachnodactyly	1.5%
698	Ectopia Cordis	1.5%
699	Ectromelia	1.5%
700	Hemimelia	1.5%
701	Meningomyelocele	1.5%
702	Phocomelia	1.5%
703	Sirenomelia	1.5%
704	Spina Bifida	1.5%
705	Polydactyly	1.5%
706	Brachydactyly	1.5%
707	Plagiocephaly	1.5%
708	Lower Extremity Deformities, Congenital	1.5%
709	Upper Extremity Deformities, Congenital	1.5%
710	Single umbilical artery	1.5%
711	Micrognathism	1.4%
712	Pierre Robin Syndrome	1.4%
713	Waterhouse-Friderichsen Syndrome	1.4%
714	Laryngomalacia	1.4%
715	Renal Osteodystrophy	1.4%
716	Renal rickets	1.4%
717	Pectus carinatum	1.4%
718	Bladder Exstrophy	1.4%
719	Epispadias	1.4%
720	Multicystic Dysplastic Kidney	1.4%
721	Retrognathia	1.3%
722	Aortic coarctation	1.3%
723	Cor Triatriatum	1.3%
724	Coronary Vessel Anomalies	1.3%
725	Dental Enamel Hypoplasia	1.3%
726	Patent ductus arteriosus	1.3%
727	Ebstein Anomaly	1.3%
728	Heart Septal Defects	1.3%
729	Hyaline Membrane Disease	1.3%
730	Hypodontia	1.3%
731	Macrostomia	1.3%
732	Meningocele	1.3%
733	Microstomia	1.3%
734	Tetralogy of Fallot	1.3%
735	Transposition of Great Vessels	1.3%
736	Hypoplastic Left Heart Syndrome	1.3%
737	May-Thurner Syndrome	1.3%
738	Encephalocele	1.3%
739	Craniofacial Dysostosis	1.3%
740	Wolff-Parkinson-White Syndrome	1.3%
741	Kernicterus	1.2%
742	Prognathism	1.2%
743	Dermal Sinus	1.2%
744	Spina Bifida Cystica	1.2%
745	Spina Bifida Occulta	1.2%
746	Lissencephaly	1.2%
747	Polymicrogyria	1.2%
748	Pachygyria	1.2%
749	Schizencephaly	1.2%
750	Periventricular Nodular Heterotopia	1.2%
751	Long QT Syndrome	1.1%
752	Platybasia	1.1%
753	Tricuspid Atresia	1.1%
754	Arrhythmogenic Right Ventricular Dysplasia	1.1%
755	Bronchomalacia	1.1%
756	Tracheomalacia	1.1%
757	Aortopulmonary Septal Defect	1.1%
758	Double Outlet Right Ventricle	1.1%
759	Endocardial Cushion Defects	1.1%
760	Myocardial bridging	1.1%
761	Aorticopulmonary Septal Defect	1.1%
762	Truncus Arteriosus, Persistent	0.9%
763	Goldenhar Syndrome	0.9%
764	Mandibulofacial Dysostosis	0.9%
765	Romano-Ward Syndrome	0.9%
766	Talipes	0.8%
767	Congenital clubfoot	0.8%
768	Vertical Talus	0.8%
769	Arteriovenous fistula	0.8%

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