MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Reperfusion Injury

(UMLS:C0035126)

Definition:: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
UMLS ID:: C0035126
MeSH ID:: D015427

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.725

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.767.877

Synonym(s)

Reperfusion Injury

Ischaemia-reperfusion injury

Ischemia-reperfusion injury

Reperfusion injury

injury reperfusion

ischemia reperfusion injury

ischemia-reperfusion injury

reperfusion damage

reperfusion injury

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	bivalirudin	FAERS: 9		SIDER US FAERS
2	Amoxicillin-Potassium Clavulanate Combination	FAERS: 3		US FAERS
3	Adenosine	FAERS: 1	11567657	CTD US FAERS
4	Bosentan	FAERS: 1		US FAERS
5	Diltiazem	FAERS: 1	8357776	CTD US FAERS
6	Edaravone	FAERS: 1	View details 14654979 15086910 15629865 15948865 16041266 16753835 25422538	CTD US FAERS
7	Epinephrine	FAERS: 1	19135123 19464573	CTD US FAERS
8	Mycophenolic Acid	FAERS: 1		US FAERS
9	NuvaRing	FAERS: 1		US FAERS
10	Rivaroxaban	FAERS: 1		US FAERS
11	Rosiglitazone	FAERS: 1	View details 12970094 16123307 16386242 17641846 18846339 21826699	CTD US FAERS
12	Rosuvastatin Calcium	FAERS: 1		US FAERS
13	rofecoxib	FAERS: 1	10594344 11567657	CTD US FAERS
14	1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one		28063877	CTD
15	15-deoxy-delta(12,14)-prostaglandin J2		12970094	CTD
16	16,16-Dimethylprostaglandin E2		11567657	CTD
17	3,5-di-tert-butyl-4-hydroxybenzoic acid		10027768	CTD
18	3-aminobenzamide		11049868 15749460	CTD
19	4-phenylbutyric acid		21767572	CTD
20	6-Ketoprostaglandin F1 alpha		12024109	CTD
21	ATL 146e		12407381	CTD
22	Acetylcysteine		19526394	CTD
23	Adenosine Triphosphate		17997382	CTD
24	Alcohols		22022451 26747958	CTD
25	Amiloride		17356886	CTD
26	Antimycin A		25087994	CTD
27	Apomorphine		15336313	CTD
28	Azithromycin		18435685	CTD
29	Capsaicin		17360009 18460982 19211983	CTD
30	Carbon Monoxide		1447108	CTD
31	Carvedilol		10569482	CTD
32	Cocaine		1326132 9650642 15677681	CTD
33	Cyclosporine		15156953 17362745	CTD
34	Deferoxamine		2225430 8322925	CTD
35	Deoxyglucose		25087994	CTD
36	Desflurane		15781515	CTD
37	Dexamethasone		10588920 12569807	CTD
38	Dextromethorphan		17102908	CTD
39	Diazoxide		12409977	CTD
40	Dihydrotestosterone		15670785	CTD
41	Dinoprostone		10594344 20609232	CTD
42	Dipyridamole		16003293	CTD
43	Ellagic Acid		9650642	CTD
44	Fenofibrate		20863214	CTD
45	Flutamide		17973111	CTD
46	Furosemide		16526316	CTD
47	Gallic Acid		24433871	CTD
48	Ganciclovir			OFFSIDES
49	Glucose		28675767	CTD
50	Glutathione Disulfide		1943082	CTD
51	Glyburide		15840025	CTD
52	Hydrogen Peroxide		16682413 19193722	CTD
53	Hydrogen Sulfide		31283913	CTD
54	Indomethacin		10588920 10594344 11567657	CTD
55	Isosorbide Dinitrate		12409977	CTD
56	Leucovorin		17295595	CTD
57	Leukotriene C4		12967936	CTD
58	Losartan		23875703	CTD
59	Malondialdehyde		View details 12910483 16938161 17032661 17470888 20609232 23743330	CTD
60	Mannitol		21748612	CTD
61	Meloxicam		10594344	CTD
62	Mifepristone		30229846	CTD
63	Minocycline		15172883	CTD
64	Morphine		19211983	CTD
65	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide		10588920 10594344	CTD
66	Nicorandil		12409977	CTD
67	Nicotine		19673871 21511693	CTD
68	Nitric Oxide		View details 10632965 15367387 16386242 17470888 20863214 23061969	CTD
69	Nitroglycerin		8869312	CTD
70	Norepinephrine			OFFSIDES
71	Oxygen		View details 9650642 11567657 24058562 24337826 25214260 27064547 27274199 27363631 27363640 27757725 28063877 28477916 28675767 28966130 29427784 30611788 31283913	CTD
72	PD 123319		14740078	CTD
73	Pentoxifylline		10673075	CTD
74	Prodigiosin		21925195	CTD
75	Propofol		View details 11954772 14707428 16938161 17032661 17470888 23353162	CTD
76	Propranolol		698989	CTD
77	Quercetin		22557973 23758074	CTD
78	Ranitidine		12023551	CTD
79	Razoxane		17119874	CTD
80	Resveratrol		View details 10594344 11567657 15827377 16314181 16376214 16971220 17058453 17520802 18572362 19135050 20036306 21850487 23075401 23284668 23353162 23435869 23735732 23748073 27064547 29427784	CTD
81	Rotenone		15720824	CTD
82	S-nitrosocysteine		17761304	CTD
83	Sevoflurane		20137656	CTD
84	Simvastatin		11470468 21844074 21968084	CTD
85	Sirolimus		11553517 17362745	CTD
86	Streptozocin		12540624	CTD
87	Tacrolimus		9655420 12892836	CTD
88	Telmisartan		20863214	CTD
89	Testosterone		16682413	CTD
90	Tetrodotoxin		17356886	CTD
91	Theophylline		16410406	CTD
92	Troglitazone		12468449	CTD
93	Verapamil		8909991	CTD
94	Vitamin D		24011919	CTD
95	Vitamin E		8891671 12910483 20609232	CTD
96	astaxanthine		19900500	CTD
97	astragaloside A		25422538	CTD
98	baicalin		22019745	CTD
99	benzamide		11049868	CTD
100	breviscapine		27363631	CTD
101	caffeic acid phenethyl ester		12910483	CTD
102	calcitonin gene-related peptide (8-37)		11567657	CTD
103	cardamonin		28966130	CTD
104	clindamycin phosphate			OFFSIDES
105	cobaltiprotoporphyrin		12352873 20357190 25780291	CTD
106	dazmegrel		10369085	CTD
107	estradiol 3-benzoate		27363640	CTD
108	falcarinol		19800326	CTD
109	genipin		28477916	CTD
110	ginsenoside Rb1		25422538	CTD
111	ginsenoside Re		18464084	CTD
112	ginsenoside Rg1		25422538	CTD
113	imidaprilat		10572926	CTD
114	mangiferin		8608170	CTD
115	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate		21289052	CTD
116	nodosin		22098251	CTD
117	notoginsenoside R1		View details 18176958 20023602 24232000 24720662 25422538	CTD
118	olmesartan		20638619	CTD
119	pirinixic acid		19058328	CTD
120	platycodin D		19433075	CTD
121	resiniferatoxin		18460982	CTD
122	reviparin		10673075	CTD
123	sodium arsenite		10216529	CTD
124	sodium bisulfide		24058562 31283913	CTD
125	tert-Butylhydroperoxide		29111459	CTD
126	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex		16682413 17997382	CTD
127	tirilazad		8891671	CTD
128	trandolapril		8909991	CTD
129	ursolic acid		27274199	CTD
130	zafirlukast		12967936	CTD
131	zileuton		9865762 15266012	CTD
132	zinc protoporphyrin		25780291 26747958	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Vasoplegia	44.8%
2	Postoperative Hemorrhage	33.9%
3	Graft Occlusion, Vascular	31.8%
4	Surgical Wound Dehiscence	31.8%
5	Delayed Emergence from Anesthesia	31.8%
6	Anastomotic Leak	31.8%
7	Postpericardiotomy Syndrome	31%
8	Aortic Aneurysm	30.5%
9	Aortitis	30.5%
10	Leriche Syndrome	30.5%
11	Periphlebitis	30.5%
12	Phlebitis	30.5%
13	Thromboangiitis Obliterans	30.5%
14	Thrombophlebitis	28.7%
15	Myocardial Ischemia	28.1%
16	Aneurysm	27.9%
17	Angiomatosis	27.9%
18	Aortic Diseases	27.9%
19	Arterial Occlusive Diseases	27.9%
20	Hyperemia	27.9%
21	Hypotension	27.9%
22	Superior Vena Cava Syndrome	27.9%
23	Telangiectasis	27.9%
24	Vasculitis	27.9%
25	Venous Insufficiency	27.9%
26	Peripheral Vascular Diseases	27.9%
27	Embolism and Thrombosis	27.9%
28	Angiodysplasia	27.9%
29	Capillary Leak Syndrome	27.9%
30	Prehypertension	27.9%
31	Postphlebitic Syndrome	27.7%
32	Incisional hernia	27.1%
33	Pain, Postoperative	26.1%
34	Retinal Vein Occlusion	25.8%
35	Blue Toe Syndrome	25.7%
36	Failed Back Surgery Syndrome	25.5%
37	Coronary Aneurysm	25.3%
38	Aortic Rupture	25.1%
39	Aortic Aneurysm, Abdominal	25%
40	Aortic Aneurysm, Thoracic	25%
41	Malignant Atrophic Papulosis	24.3%
42	Shwartzman Phenomenon	24.2%
43	Prosthesis Failure	24.1%
44	Corneal Endothelial Cell Loss	24.1%
45	Carotid Artery Thrombosis	23.8%
46	Surgical Wound Infection	23.7%
47	Afferent Loop Syndrome	23.5%
48	Short Bowel Syndrome	23.5%
49	Coronary Thrombosis	23.2%
50	Coronary Artery Disease	23.2%
51	No-Reflow Phenomenon	22.7%
52	Postoperative Nausea and Vomiting	22.7%
53	Intracranial Embolism and Thrombosis	22%
54	Carotid Stenosis	21.9%
55	Intracranial Aneurysm	21.9%
56	Vascular System Injuries	21.8%
57	Moyamoya Disease	21.8%
58	Shock, Cardiogenic	21.3%
59	Compartment syndromes	21.1%
60	Hepatic Veno-Occlusive Disease	21.1%
61	Peliosis Hepatis	21.1%
62	Varicocele	21.1%
63	Polydipsia	21.1%
64	Ascites	20.9%
65	Fibrosis	20.9%
66	Gliosis	20.9%
67	Growth Disorders	20.9%
68	Hemorrhage	20.9%
69	Hyperbilirubinemia	20.9%
70	Hyperplasia	20.9%
71	Hypomenorrhea	20.9%
72	Inflammation	20.9%
73	Intraoperative Complications	20.9%
74	Ischemia	20.9%
75	Lithiasis	20.9%
76	Malacoplakia	20.9%
77	Menstruation Disturbances	20.9%
78	Metaplasia	20.9%
79	Nerve Degeneration	20.9%
80	Ochronosis	20.9%
81	Polymenorrhea	20.9%
82	Sclerosis	20.9%
83	Shock	20.9%
84	Ulcer	20.9%
85	Hyperammonemia	20.9%
86	Hyperamylasemia	20.9%
87	Teratogenesis	20.9%
88	Cardiac Death	20.9%
89	Hypovolemia	20.9%
90	Hyperuricemia	20.9%
91	Leukoaraiosis	20.9%
92	Dysbacteriosis	20.9%
93	Delayed Graft Function	20.9%
94	Cirrhosis	20.9%
95	Neointima	20.9%
96	Dysbiosis	20.9%
97	Cerebrovascular Disorders	20.7%
98	Diabetic Angiopathies	20.7%
99	Splenic Infarction	20.7%
100	Cerebrovascular Insufficiency	20.7%
101	Vascular Neoplasms	20.7%
102	Spinal Cord Vascular Diseases	20.7%
103	Hemorrhoids	20.5%
104	Thoracic Outlet Syndrome	20.5%
105	Aneurysm, Dissecting	20.5%
106	Arteriosclerosis	20.5%
107	Arteritis	20.5%
108	Embolism	20.5%
109	Erythromelalgia	20.5%
110	Fibromuscular Dysplasia	20.5%
111	Malignant Hypertension	20.5%
112	Raynaud Disease	20.5%
113	Thromboembolism	20.5%
114	Thrombosis	20.5%
115	Essential Hypertension	20.5%
116	Aneurysm, Ruptured	20.5%
117	Iliac Aneurysm	20.5%
118	Pulmonary artery stenosis	20.5%
119	White Coat Hypertension	20.5%
120	Systemic Vasculitis	20.5%
121	Embolus	20.5%
122	Coronary heart disease	20.3%
123	Infarction	20.3%
124	Myocardial Infarction	20.3%
125	Shock, Hemorrhagic	20.3%
126	Systemic Inflammatory Response Syndrome	20.3%
127	Acute Coronary Syndrome	20.3%
128	Arteriovenous fistula	20.2%
129	Polyarteritis Nodosa	20%
130	Takayasu Arteritis	20%
131	Intracranial Arteriosclerosis	19.8%
132	Cerebral Atherosclerosis	19.8%
133	Cerebral Arteriosclerosis	19.8%
134	Cerebral Thrombosis	18.8%
135	Intracranial Embolism	18.8%
136	Intracranial Thrombosis	18.8%
137	Intermittent Claudication	17.9%
138	Angina Pectoris	17.7%
139	Dumping Syndrome	17.5%
140	Vasculitis, Central Nervous System	17.4%
141	Sinus Thrombosis, Intracranial	17.2%
142	Hand-Arm Vibration Syndrome	17.1%
143	Vascular Remodeling	16.9%
144	Arteriosclerosis Obliterans	16.9%
145	Atherosclerosis	16.9%
146	Air Embolism	16.9%
147	Endarteritis	16.9%
148	Venous Thrombosis	16.9%
149	Deep Vein Thrombosis	16.9%
150	Venous Thromboembolism	16.9%
151	Coronary Occlusion	16.7%
152	Optic Neuropathy, Ischemic	16.7%
153	Microvascular Angina	16.7%
154	Coronary Stenosis	16.7%
155	Anterior Ischemic Optic Neuropathy	16.7%
156	Mesenteric vascular insufficiency	16.7%
157	ST segment elevation myocardial infarction	16.7%
158	Lemierre Syndrome	16.5%
159	Giant Cell Arteritis	16.5%
160	Temporal Arteritis	16.5%
161	Kounis Syndrome	16.4%
162	Brain Infarction	16.4%
163	Cavernous Sinus Thrombosis	16.4%
164	Sagittal Sinus Thrombosis	16.4%
165	Extravasation of Diagnostic and Therapeutic Materials	16.4%
166	Neoplastic Processes	16.4%
167	Angioedema	16.2%
168	Heart Block	16.2%
169	Tachycardia	16.2%
170	Tachyarrhythmia	16.2%
171	Colitis, Ischemic	16.2%
172	May-Thurner Syndrome	16.1%
173	Subarachnoid Hemorrhage	15.8%
174	Cerebral Hemorrhage	15.8%
175	Necrosis	15.8%
176	Granulomatosis, Orofacial	15.8%
177	Pigmentation Disorders	15.8%
178	Respiratory Aspiration	15.8%
179	Infarction, Middle Cerebral Artery	15.7%
180	Infarction, Anterior Cerebral Artery	15.7%
181	Infarction, Posterior Cerebral Artery	15.7%
182	Embolism, Amniotic Fluid	15.6%
183	Acantholysis	15.5%
184	Chromosome Aberrations	15.5%
185	Dehydration	15.5%
186	Granuloma	15.5%
187	Leukocytosis	15.5%
188	Retinal Artery Occlusion	15.5%
189	Pleocytosis	15.5%
190	Retinal Vasculitis	15.5%
191	Hypertensive Retinopathy	15.5%
192	Sick Sinus Syndrome	15.5%
193	Anterior Compartment Syndrome	15.3%
194	Sinus Arrhythmia	15.3%
195	Atrial Fibrillation	15.3%
196	Atrial Flutter	15.3%
197	Ventricular Fibrillation	15.3%
198	Vasculitis, Leukocytoclastic, Cutaneous	15.3%
199	Ventricular Flutter	15.3%
200	Parasystole	15.3%
201	Paroxysmal atrial fibrillation	15.3%
202	Gastric Antral Vascular Ectasia	15.3%
203	Bradycardia	15.3%
204	Abdominal Compartment Syndrome	15.3%
205	Subarachnoid Hemorrhage, Traumatic	15.1%
206	Carotid Artery, Internal, Dissection	15.1%
207	Carotid Artery Diseases	15.1%
208	Brain Ischemia	15.1%
209	Hypotension, Orthostatic	15.1%
210	Cerebrovascular accident	15.1%
211	Varicose Ulcer	15.1%
212	Vasospasm, Intracranial	15.1%
213	Spinal Cord Ischemia	15.1%
214	Intracranial Arterial Diseases	15.1%
215	Post-Exercise Hypotension	15.1%
216	Sudden infant death syndrome	15%
217	Coronary Restenosis	14.9%
218	Livedo Reticularis	14.9%
219	Angina, Unstable	14.7%
220	Cerebral Infarction	14.6%
221	Heart Diseases	14.6%
222	Brain Stem Infarctions	14.6%
223	Basal Ganglia Hemorrhage	14.6%
224	Myocardial Reperfusion Injury	14.4%
225	Vertebral Artery Dissection	14.2%
226	Purpura, Hyperglobulinemic	14.2%
227	Menorrhagia	14%
228	Lateral Medullary Syndrome	13.8%
229	Acute Disease	13.6%
230	Acute-Phase Reaction	13.6%
231	Amenorrhea	13.6%
232	Chronic disease	13.6%
233	Critical Illness	13.6%
234	Sudden death	13.6%
235	Fat necrosis	13.6%
236	Gangrene	13.6%
237	Granuloma, Plasma Cell	13.6%
238	Hematoma	13.6%
239	Iatrogenic Disease	13.6%
240	Multiple Organ Failure	13.6%
241	Oligomenorrhea	13.6%
242	Premenstrual syndrome	13.6%
243	Recurrence	13.6%
244	Retrograde Degeneration	13.6%
245	Retroperitoneal fibrosis	13.6%
246	Serositis	13.6%
247	Subcutaneous Emphysema	13.6%
248	Syndrome	13.6%
249	Wallerian Degeneration	13.6%
250	Pyogenic granuloma	13.6%
251	Exsanguination	13.6%
252	Disease Progression	13.6%
253	Seroma	13.6%
254	Premenstrual Tension	13.6%
255	Infant Death	13.6%
256	Intraoperative Awareness	13.6%
257	Chromosomal Instability	13.6%
258	jaundice	13.6%
259	CREST Syndrome	13.6%
260	Long QT Syndrome	13.4%
261	Putaminal Hemorrhage	13.3%
262	Angina Pectoris, Variant	13.2%
263	Scimitar Syndrome	12.9%
264	Genomic Instability	12.9%
265	Hematoma, Subdural	12.8%
266	Hematoma, Epidural, Cranial	12.8%
267	Pulmonary Embolism	12.8%
268	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	12.8%
269	Sudden Cardiac Death	12.6%
270	Adams-Stokes Syndrome	12.6%
271	Atrioventricular Block	12.6%
272	Bundle-Branch Block	12.6%
273	Atrial Premature Complexes	12.6%
274	Sinoatrial Block	12.6%
275	Tachycardia, Paroxysmal	12.6%
276	Supraventricular tachycardia	12.6%
277	Tachycardia, Ventricular	12.6%
278	Tachycardia, Reciprocating	12.6%
279	Cerebral Arterial Diseases	12.4%
280	Vertebrobasilar Insufficiency	12.4%
281	Anterior Spinal Artery Syndrome	12.4%
282	Basilar Artery Stenosis	12.4%
283	Vertebral Artery Stenosis	12.4%
284	Intracranial Hemorrhage, Hypertensive	12.4%
285	Transient Cerebral Ischemia	12.4%
286	Carotid Artery Injuries	12.3%
287	Mesenteric Vascular Occlusion	12.3%
288	Mucocutaneous Lymph Node Syndrome	12.3%
289	Cardiac Output, High	12.3%
290	Myocardial Stunning	12.3%
291	Low Cardiac Output Syndrome	12.3%
292	Diabetic Retinopathy	12.2%
293	Sturge-Weber Syndrome	12.2%
294	Phantom pain	12.2%
295	Phantom Limb Pain	12.2%
296	Signs and Symptoms	12.2%
297	Pathological Conditions, Anatomical	12.2%
298	Dysmenorrhea	12.1%
299	Azotemia	12.1%
300	Renal hypertension	12.1%
301	Renal Artery Obstruction	12.1%
302	Renal Artery Stenosis	12.1%
303	Hemangioma, Cavernous	12%
304	Muscle Weakness	12%
305	Basal Ganglia Cerebrovascular Disease	12%
306	Vascular Headaches	12%
307	Scurvy	11.9%
308	Sinus Arrest, Cardiac	11.7%
309	Hepatic Vein Thrombosis	11.5%
310	Budd-Chiari Syndrome	11.5%
311	Pulmonary Infarction	11.3%
312	Eye Hemorrhage	11.3%
313	Hematoma, Subdural, Intracranial	11.2%
314	Hematoma, Subdural, Chronic	11.2%
315	Hematoma, Subdural, Acute	11.2%
316	Subclavian Steal Syndrome	11.1%
317	Endotoxic shock	11%
318	Septic Shock	11%
319	Toxic Shock Syndrome	11%
320	Hemoptysis	11%
321	Pregnancy Complications, Cardiovascular	10.9%
322	Cardiovascular Abnormalities	10.9%
323	Tachycardia, Atrioventricular Nodal Reentry	10.8%
324	Tachycardia, Ectopic Atrial	10.8%
325	Tachycardia, Ectopic Junctional	10.8%
326	Sinus Tachycardia	10.8%
327	Torsades de Pointes	10.8%
328	Accelerated Idioventricular Rhythm	10.8%
329	Ecchymosis	10.8%
330	Petechiae	10.8%
331	Purpura	10.8%
332	Asphyxia	10.7%
333	Granuloma, Respiratory Tract	10.7%
334	Shock, Traumatic	10.7%
335	Romano-Ward Syndrome	10.4%
336	Cardiotoxicity	10.4%
337	Disease susceptibility	10.3%
338	Fetal Death	10.3%
339	Foreign-Body Reaction	10.3%
340	Gastrointestinal Hemorrhage	10.3%
341	Cardiomegaly	10.3%
342	Hemarthrosis	10.3%
343	Hemoperitoneum	10.3%
344	Hemothorax	10.3%
345	Neoplasm Invasiveness	10.3%
346	Neoplasm Metastasis	10.3%
347	Neoplasm Recurrence, Local	10.3%
348	Injection Site Reaction	10.3%
349	Retrobulbar Hemorrhage	10.3%
350	Aseptic Necrosis of Bone	10.3%
351	Peritoneal Fibrosis	10.3%
352	Carcinogenesis	10.3%
353	Neurogenic Inflammation	10.3%
354	Perinatal death	10.3%
355	Infusion site reaction	10.3%
356	Cardiac Hypertrophy	10.3%
357	Nephrogenic Fibrosing Dermopathy	10.3%
358	Encapsulating Peritoneal Sclerosis	10.3%
359	Suppuration	10.3%
360	Nephrogenic Systemic Fibrosis	10.3%
361	Metastasis	10.3%
362	Aortic Valve Stenosis	10.2%
363	Cardiomyopathy, Dilated	10.2%
364	Dental Pulp Necrosis	10.2%
365	Granuloma, Foreign-Body	10.2%
366	Mediastinal Emphysema	10.2%
367	Pulmonary Valve Stenosis	10.2%
368	Facies	10.2%
369	Embryo Loss	10.2%
370	Tissue Adhesions	10.1%
371	Ischemic contracture	10.1%
372	Hematoma, Epidural, Spinal	10.1%
373	Sex Chromosome Aberrations	10.1%
374	Uterine hemorrhage	10.1%
375	Angioedemas, Hereditary	10.1%
376	Tricuspid Atresia	10.1%
377	Arrhythmogenic Right Ventricular Dysplasia	10.1%
378	Cryoglobulinemia	10%
379	Jaundice, Obstructive	10%
380	Leukomalacia, Periventricular	10%
381	Chromosome Fragility	9.9%
382	Diabetic Foot	9.9%
383	Hypertension, Renovascular	9.9%
384	Hypoxia-Ischemia, Brain	9.9%
385	Hereditary Angioedema Type III	9.8%
386	Hereditary Angioedema Types I and II	9.8%
387	Dementia, Vascular	9.8%
388	Cardiac Tamponade	9.3%
389	Endocarditis	9.3%
390	Cardiac Arrest	9.3%
391	Heart failure	9.3%
392	Pericardial effusion	9.3%
393	Pericarditis	9.3%
394	Pneumopericardium	9.3%
395	Cor pulmonale	9.3%
396	Ventricular Outflow Obstruction	9.3%
397	Ventricular Dysfunction	9.3%
398	Cardiomyopathies	9.3%
399	Pleuropericarditis	9.3%
400	Epistaxis	9.2%
401	Granulomatosis with polyangiitis	9%
402	Cerebral Amyloid Angiopathy	8.9%
403	Hypertrophic Cardiomyopathy	8.8%
404	Hypertrophic obstructive cardiomyopathy	8.8%
405	Shy-Drager Syndrome	8.5%
406	Edema, Cardiac	8.5%
407	Drowning	8.5%
408	Trisomy	8.5%
409	Hematoma, Subdural, Spinal	8.4%
410	Supravalvular aortic stenosis	8.3%
411	Lown-Ganong-Levine Syndrome	8.3%
412	Pituitary Apoplexy	8.3%
413	Fetal Growth Retardation	8.2%
414	DNA Degradation, Necrotic	8.2%
415	Aneuploidy	8.2%
416	Polyploidy	8.2%
417	Microsatellite Instability	8.2%
418	Cicatrix	8.1%
419	Aortic coarctation	8.1%
420	Cor Triatriatum	8.1%
421	Coronary Vessel Anomalies	8.1%
422	Patent ductus arteriosus	8.1%
423	Ebstein Anomaly	8.1%
424	Heart Septal Defects	8.1%
425	Hematuria	8.1%
426	Tetralogy of Fallot	8.1%
427	Transposition of Great Vessels	8.1%
428	Granuloma Annulare	8.1%
429	Hypoplastic Left Heart Syndrome	8.1%
430	Chromosome Breakage	8.1%
431	Bacterial Endocarditis	8%
432	Brain Death	8%
433	Hematemesis	8%
434	Purpura Fulminans	7.9%
435	Cross Infection	7.7%
436	Hyphema	7.7%
437	Retinal Neovascularization	7.7%
438	Septicemia	7.7%
439	Vitreous Hemorrhage	7.7%
440	Sepsis	7.7%
441	Abscess	7.6%
442	Empyema	7.6%
443	Femur Head Necrosis	7.6%
444	Fetal Resorption	7.6%
445	Lymphatic Metastasis	7.6%
446	Neoplasms, Unknown Primary	7.6%
447	Peptic Ulcer Hemorrhage	7.6%
448	Left Ventricular Hypertrophy	7.6%
449	Leukemic Infiltration	7.6%
450	Right Ventricular Hypertrophy	7.6%
451	Premenstrual Dysphoric Disorder	7.6%
452	Choroidal Neovascularization	7.6%
453	Neoplasm Micrometastasis	7.6%
454	Behcet Syndrome	7.5%
455	Lupus Vasculitis, Central Nervous System	7.5%
456	Waldenstrom Macroglobulinemia	7.5%
457	Multiple Myeloma	7.5%
458	Cicatrix, Hypertrophic	7.5%
459	Metrorrhagia	7.5%
460	Rheumatoid Vasculitis	7.1%
461	Asthenia	7%
462	Body Temperature Changes	7%
463	Calculi	7%
464	Cyanosis	7%
465	Edema	7%
466	Failure to Thrive	7%
467	Fatigue	7%
468	Feminization	7%
469	Fetal Distress	7%
470	Hernia	7%
471	Hypertrophy	7%
472	Motion Sickness	7%
473	Nails, Malformed	7%
474	polyps	7%
475	Rupture, Spontaneous	7%
476	Signs and Symptoms, Digestive	7%
477	Signs and Symptoms, Respiratory	7%
478	Skin Manifestations	7%
479	Chills	7%
480	Lassitude	7%
481	Enterocele	7%
482	Atheroma	7%
483	Pseudophakia	7%
484	Urological Manifestations	7%
485	Stenosis	7%
486	Facial asymmetry	7%
487	Mobility Limitation	7%
488	Somnolence	7%
489	Plaque, Amyloid	7%
490	Plaque, Atherosclerotic	7%
491	Giant Cell Epulis	6.9%
492	Aortic Valve Insufficiency	6.8%
493	Restrictive cardiomyopathy	6.8%
494	Endocardial Fibroelastosis	6.8%
495	Heart Rupture, Post-Infarction	6.8%
496	Mitral Valve Insufficiency	6.8%
497	Mitral Valve Stenosis	6.8%
498	Myocarditis	6.8%
499	Pericarditis, Constrictive	6.8%
500	Pulmonary Valve Insufficiency	6.8%
501	Tricuspid Valve Insufficiency	6.8%
502	Tricuspid Valve Stenosis	6.8%
503	Ventricular Dysfunction, Left	6.8%
504	Right Ventricular Dysfunction	6.8%
505	Endomyocardial Fibrosis	6.8%
506	Carditis	6.8%
507	Heart Failure, Systolic	6.8%
508	Heart Failure, Diastolic	6.8%
509	Rheumatic Heart Disease	6.8%
510	Ataxia Telangiectasia	6.8%
511	Pseudoxanthoma Elasticum	6.7%
512	Dextrocardia	6.7%
513	Wolff-Parkinson-White Syndrome	6.6%
514	Viremia	6.6%
515	Parasitemia	6.6%
516	Aortopulmonary Septal Defect	6.6%
517	Double Outlet Right Ventricle	6.6%
518	Endocardial Cushion Defects	6.6%
519	Myocardial bridging	6.6%
520	Aorticopulmonary Septal Defect	6.6%
521	Micronuclei, Chromosome-Defective	6.6%
522	Retinal Hemorrhage	6.2%
523	Choroid Hemorrhage	6.1%
524	Melena	6.1%
525	Dyspnea, Paroxysmal	6%
526	Postpartum Hemorrhage	6%
527	Gingival Hemorrhage	6%
528	Keloid	6%
529	Monosomy	6%
530	Tetraploidy	6%
531	Stillbirth	6%
532	Truncus Arteriosus, Persistent	5.9%
533	Abdominal Pain	5.9%
534	Subacute Combined Degeneration	5.8%
535	Thrombocytopenic purpura	5.8%
536	Eosinophilic Granuloma	5.7%
537	Aortic Valve Prolapse	5.6%
538	Tricuspid Valve Prolapse	5.6%
539	Takotsubo Cardiomyopathy	5.6%
540	Cyst	5.5%
541	Eye Manifestations	5.5%
542	Neurologic Manifestations	5.5%
543	Leukoplakia	5.3%
544	Reticulocytosis	5.3%
545	Airway Remodeling	5.3%
546	Subacute Bacterial Endocarditis	5.2%
547	Ventricular Remodeling	5.2%
548	Alopecia	5.1%
549	Androgenetic Alopecia	5.1%
550	Bacteremia	5.1%
551	Cellulitis	5.1%
552	Diabetic Cardiomyopathies	5.1%
553	Kernicterus	5.1%
554	Cell Transformation, Viral	5.1%
555	Cardiomyopathy, Alcoholic	5%
556	Ectopia Cordis	5%
557	Noonan Syndrome	5%
558	Single umbilical artery	5%
559	Renal Colic	5%
560	Chagas Cardiomyopathy	5%
561	Fungemia	5%
562	Brain Hemorrhage, Traumatic	4.9%
563	Eye pain	4.8%
564	Muscular Atrophy	4.7%
565	Purpura, Thrombotic Thrombocytopenic	4.7%
566	Abdomen, Acute	4.6%
567	Anorexia	4.5%
568	Anoxia	4.5%
569	Constipation	4.5%
570	Diarrhea	4.5%
571	Dyspepsia	4.5%
572	Eructation	4.5%
573	Fever	4.5%
574	Flatulence	4.5%
575	Flushing	4.5%
576	Halitosis	4.5%
577	Heartburn	4.5%
578	Diaphragmatic Hernia	4.5%
579	Hiccough	4.5%
580	Hypercalciuria	4.5%
581	Hypercapnia	4.5%
582	Hyperphagia	4.5%
583	Intestinal Polyps	4.5%
584	Nausea	4.5%
585	Pallor	4.5%
586	Psychophysiologic Disorders	4.5%
587	Splenomegaly	4.5%
588	Vomiting	4.5%
589	Hypocapnia	4.5%
590	Dyschezia	4.5%
591	Hypoxia	4.5%
592	Hyperoxia	4.5%
593	Lower Urinary Tract Symptoms	4.5%
594	Hypoxemia	4.5%
595	Urinoma	4.5%
596	Marfan Syndrome	4.5%
597	Endotoxemia	4.5%
598	Granuloma, Laryngeal	4.4%
599	MELAS Syndrome	4.4%
600	Carcinoid Heart Disease	4.4%
601	Hypergammaglobulinemia	4.2%
602	Diverticulum	4.1%
603	Diverticulosis	4.1%
604	Autoimmune thrombocytopenia	3.7%
605	Immune thrombocytopenic purpura	3.7%
606	Sarcopenia	3.6%
607	Philadelphia Chromosome	3.6%
608	Respiratory Tract Fistula	3.6%
609	Waterhouse-Friderichsen Syndrome	3.6%
610	Apnea	3.4%
611	Cheyne-Stokes Respiration	3.4%
612	Decerebrate State	3.4%
613	Dyspnea	3.4%
614	Hemiparesis	3.4%
615	Hepatomegaly	3.4%
616	Hyperventilation	3.4%
617	Meningism	3.4%
618	Mouth Breathing	3.4%
619	Paresis	3.4%
620	Parovarian Cyst	3.4%
621	Pruritus	3.4%
622	Seizures	3.4%
623	Sensation Disorders	3.4%
624	Sneezing	3.4%
625	Spermatocele	3.4%
626	Erythema	3.4%
627	Oral Fistula	3.4%
628	Complex partial seizures	3.4%
629	Necrolytic Migratory Erythema	3.4%
630	Tachypnea	3.4%
631	Monoparesis	3.4%
632	Cutaneous Fistula	3.4%
633	Gait Disorders, Neurologic	3.4%
634	Neuromuscular Manifestations	3.4%
635	Fabry Disease	3.4%
636	Mental Fatigue	3.4%
637	Hirsutism	3.4%
638	Dural Arteriovenous Fistula	3.4%
639	Orthostatic intolerance	3.4%
640	Hypoventilation	3.4%
641	Back Pain	3.4%
642	Bulimia	3.4%
643	Neck Pain	3.4%
644	Chest Pain	3.4%
645	Colonic Polyps	3.4%
646	Dizziness	3.4%
647	Dysuria	3.4%
648	Facial Pain	3.4%
649	Fever of Unknown Origin	3.4%
650	Flank Pain	3.4%
651	Headache	3.4%
652	Nocturia	3.4%
653	Pain, Intractable	3.4%
654	Pelvic Pain	3.4%
655	Snoring	3.4%
656	Chronic pain	3.4%
657	Lightheadedness	3.4%
658	Pain, Referred	3.4%
659	Prostatism	3.4%
660	Throbbing Headache	3.4%
661	Labor Pain	3.4%
662	Cancer Pain	3.4%
663	Nociceptive Pain	3.4%
664	Vaginal Fistula	3.4%
665	Rectocele	3.4%
666	Body Weight Changes	3.3%
667	Candidemia	3.2%
668	Gait Ataxia	3%
669	Hoarseness	3%
670	Sleep Wake Disorders	2.9%
671	Pupil Disorders	2.9%
672	Neurobehavioral Manifestations	2.9%
673	Body Weight	2.8%
674	Emaciation	2.8%
675	Low Back Pain	2.8%
676	Visceral Pain	2.8%
677	Nasal Polyps	2.8%
678	Pleural Rub	2.7%
679	Rales	2.7%
680	Respiratory Sounds	2.7%
681	Rhonchi	2.7%
682	Stridor	2.7%
683	Wheezing	2.7%
684	Asterixis	2.7%
685	Ballismus	2.7%
686	Vertigo	2.7%
687	Pain	2.7%
688	Ache	2.7%
689	Meningocele	2.7%
690	Oliguria	2.7%
691	Polyuria	2.7%
692	Proteinuria	2.7%
693	Urinary Calculi	2.7%
694	Encephalocele	2.7%
695	Underweight	2.6%
696	Overweight	2.6%
697	Akathisia	2.6%
698	Restlessness	2.6%
699	Psychomotor Agitation	2.6%
700	Turner Syndrome	2.6%
701	Biliary Fistula	2.6%
702	Gastric Fistula	2.6%
703	Congenital diaphragmatic hernia	2.6%
704	Morning Sickness	2.6%
705	Vesicovaginal Fistula	2.6%
706	Anosmia	2.5%
707	Ataxia	2.5%
708	Athetosis	2.5%
709	Catalepsy	2.5%
710	Dental Fistula	2.5%
711	Dystonia	2.5%
712	Hemiplegia	2.5%
713	Locked-In Syndrome	2.5%
714	Muscle Hypertonia	2.5%
715	Muscle hypotonia	2.5%
716	Myoclonus	2.5%
717	Myotonia	2.5%
718	Neuralgia	2.5%
719	Oroantral Fistula	2.5%
720	Paraplegia	2.5%
721	Pseudobulbar Palsy	2.5%
722	Quadriplegia	2.5%
723	Spasm	2.5%
724	Spastic Paraplegia	2.5%
725	Status Epilepticus	2.5%
726	Taste Disorders	2.5%
727	Tremor	2.5%
728	Monoplegia	2.5%
729	Hypokinesia	2.5%
730	Gastroparesis	2.5%
731	Paraparesis	2.5%
732	Bradykinesia	2.5%
733	Waxy flexibility	2.5%
734	Action Tremor	2.5%
735	Resting Tremor	2.5%
736	Dysosmia	2.5%
737	Quadriparesis	2.5%
738	Olfaction Disorders	2.5%
739	Myokymia	2.5%
740	Somatosensory Disorders	2.5%
741	Neuropathic pain	2.5%
742	Hyperkinesia	2.5%
743	Intention tremor	2.5%
744	Cachexia	2.5%
745	Rectal Prolapse	2.5%
746	Uterine Prolapse	2.5%
747	Vaginal Prolapse	2.5%
748	Williams Syndrome	2.5%
749	Weight Gain	2.5%
750	Gait Apraxia	2.5%
751	Kartagener Syndrome	2.4%
752	Voice Disorders	2.3%
753	Voice Disturbance	2.3%
754	Gagging	2.3%
755	Leukoplakia, Oral	2.2%
756	Kearns-Sayre syndrome	2.2%
757	Umbilical hernia	2.1%
758	Toothache	2.1%
759	Alexia	2.1%
760	Vision Disorders	2.1%
761	Metamorphopsia	2.1%
762	Dyslexia	2.1%
763	Visual Impairment	2.1%
764	Hyperemesis Gravidarum	2.1%
765	Dysgeusia	2.1%
766	Formication	2.1%
767	Hyperalgesia	2.1%
768	Hyperesthesia	2.1%
769	Hypesthesia	2.1%
770	Language Disorders	2.1%
771	Numbness	2.1%
772	Paresthesia	2.1%
773	Paraparesis, Spastic	2.1%
774	Trismus	2.1%
775	Epilepsia Partialis Continua	2.1%
776	Hypogeusia	2.1%
777	Brown-Sequard Syndrome	2.1%
778	Lockjaw	2.1%
779	Allodynia	2.1%
780	Ageusia	2.1%
781	Bronchial Fistula	2.1%
782	Metatarsalgia	2.1%
783	Pancreatic Fistula	2.1%
784	Alice in Wonderland Syndrome	2%
785	Anisocoria	2%
786	Confusion	2%
787	Facial paralysis	2%
788	Intestinal Fistula	2%
789	Lethargy	2%
790	Memory Disorders	2%
791	Muscle Cramp	2%
792	Perceptual Disorders	2%
793	Psychomotor Disorders	2%
794	Tonic Pupil	2%
795	Anhedonia	2%
796	Disorientation	2%
797	Gastroschisis	2%
798	Enterocutaneous Fistula	2%
799	Fetal Hypoxia	2%
800	Facial Paresis	2%
801	Memory Loss	2%
802	Hemisensory Neglect	2%
803	Dysacusis	2%
804	Mastodynia	2%
805	Respiratory Paralysis	2%
806	Salivary Gland Fistula	2%
807	Chorea	2%
808	Cystocele	2%
809	Tetany	2%
810	Urinary Incontinence	2%
811	Breakthrough Pain	2%
812	Albuminuria	2%
813	Hemoglobinuria	2%
814	Jet Lag Syndrome	1.9%
815	Reflex, Abnormal	1.9%
816	Hyporeflexia	1.9%
817	Hyperreflexia	1.9%
818	Birth Weight	1.9%
819	Agraphia	1.9%
820	Anomia	1.9%
821	Cluttering	1.9%
822	Language Development Disorders	1.9%
823	Speech Disorders	1.9%
824	Syncope	1.9%
825	Stupor	1.9%
826	Dysgraphia	1.9%
827	Presyncope	1.9%
828	Dyslalia	1.9%
829	Aphasia	1.7%
830	Articulation Disorders	1.7%
831	Echolalia	1.7%
832	Stuttering	1.7%
833	Dysphasia	1.7%
834	Consciousness Disorders	1.7%
835	Mental Retardation	1.7%
836	Depressed Level of Consciousness	1.7%
837	Mental deficiency	1.7%
838	Intellectual Disability	1.7%
839	Catatonia	1.7%
840	Musculoskeletal Pain	1.7%
841	Ophthalmoplegia	1.7%
842	External Ophthalmoplegia	1.7%
843	Dysarthria	1.7%
844	Diplopia	1.7%
845	Muscle Rigidity	1.7%
846	Muscle Spasticity	1.7%
847	Scotoma	1.7%
848	Photophobia	1.7%
849	Cogwheel Rigidity	1.7%
850	Hemifacial Spasm	1.7%
851	Amaurosis	1.7%
852	Blindness	1.7%
853	Nuchal Rigidity	1.7%
854	Aphonia	1.7%
855	Arthralgia	1.7%
856	Sleep Deprivation	1.7%
857	Polyarthralgia	1.7%
858	Dysphonia	1.7%
859	Agnosia	1.7%
860	Apraxias	1.7%
861	Hallucinations	1.7%
862	Hemianopsia	1.7%
863	Hyperacusis	1.7%
864	Tinnitus	1.7%
865	Visual Agnosia	1.7%
866	Anosognosia	1.7%
867	Wernicke-Korsakoff Syndrome	1.7%
868	Phonophobia	1.7%
869	Hearing Loss	1.7%
870	Cerebrospinal Fluid Otorrhea	1.7%
871	Cerebrospinal Fluid Rhinorrhea	1.7%
872	Cerebellar Ataxia	1.7%
873	Torticollis	1.7%
874	Sciatica	1.6%
875	Urge Incontinence	1.6%
876	Tardive Dyskinesia	1.6%
877	Obesity	1.6%
878	Amaurosis Fugax	1.5%
879	Blindness, Cortical	1.5%
880	Dyscalculia	1.5%
881	Hydrops Fetalis	1.5%
882	Deafness	1.5%
883	Hearing Loss, Sudden	1.5%
884	Gerstmann Syndrome	1.5%
885	Hearing Loss, Bilateral	1.5%
886	Hearing Loss, High-Frequency	1.5%
887	Hearing Loss, Mixed Conductive-Sensorineural	1.5%
888	Prosopagnosia	1.5%
889	Apraxia, Ideomotor	1.5%
890	Persistent Vegetative State	1.5%
891	Charles Bonnet Syndrome	1.5%
892	Hearing Loss, Unilateral	1.5%
893	Complete Hearing Loss	1.5%
894	Alien Hand Syndrome	1.5%
895	Deaf Mutism	1.5%
896	Vocal Cord Paralysis	1.5%
897	Fetal Weight	1.5%
898	Urinary Bladder Fistula	1.4%
899	Mutism	1.4%
900	Selective Mutism	1.4%
901	Tinea Pedis	1.4%
902	Amblyopia	1.4%
903	Amnesia	1.4%
904	Delirium	1.4%
905	Horner Syndrome	1.4%
906	Dissociative Amnesia	1.4%
907	Color blindness	1.4%
908	Global Amnesia	1.4%
909	Rectal Fistula	1.4%
910	Anal Fistula	1.4%
911	Shoulder Pain	1.4%
912	Alexia, Pure	1.4%
913	Pediatric Obesity	1.4%
914	Dyskinesia, Drug-Induced	1.3%
915	Alcohol Withdrawal Seizures	1.2%
916	Retrograde amnesia	1.2%
917	Amnesia, Anterograde	1.2%
918	Akathisia, Drug-Induced	1.2%
919	Myalgia	1.2%
920	Kidney Calculi	1.1%
921	Ureteral Calculi	1.1%
922	Amnesia, Transient Global	1.1%
923	Auditory Perceptual Disorders	1%
924	Ophthalmoplegic Migraine	0.9%
925	Progressive supranuclear palsy	0.9%

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