MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Autoimmune Lymphoproliferative Syndrome

(UMLS:C1328840)

Definition:: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.
UMLS ID:: C1328840
MeSH ID:: D056735

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.515.138

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.089

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.288|C20.683.515.124

Synonym(s)

Autoimmune Lymphoproliferative Syndrome

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

Autoimmune lymphoproliferative syndrome

Autoimmune lymphoproliferative syndrome [ALPS]

Canale-Smith Syndrome

Canale-Smith syndrome

autoimmune lymphoproliferative syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Tacrolimus	FAERS: 2		US FAERS
2	Cyclosporine	FAERS: 1		US FAERS
3	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
4	Maloprim		17674358	CTD
5	Mycophenolic Acid		15877736	CTD
6	tofacitinib		26453583	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sezary Syndrome	35.3%
2	Tumor Lysis Syndrome	35.2%
3	Lymphoma	30.4%
4	Infectious Mononucleosis	27.8%
5	Heavy Chain Disease	23.7%
6	Hodgkin Disease	22.6%
7	Lymphoma, Non-Hodgkin	22.6%
8	Agammaglobulinemia	22.5%
9	Leukemia, T-Cell	22.5%
10	Leukemia, B-Cell	22.5%
11	Primary amyloidosis	21.9%
12	Antiphospholipid Syndrome	20.8%
13	Composite Lymphoma	19.7%
14	Lymphangioleiomyomatosis	19.6%
15	Multiple Myeloma	19.5%
16	Plasmacytoma	19.3%
17	Sarcoidosis	19.2%
18	Lymphoma, Follicular	18.8%
19	T-Cell Lymphoma	18.8%
20	Mantle cell lymphoma	18.8%
21	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	18.8%
22	Leukemia, Large Granular Lymphocytic	18.8%
23	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	18.8%
24	Wiskott-Aldrich Syndrome	18.6%
25	Fragile X Syndrome	18.4%
26	Anemia, Sickle Cell	17.9%
27	Thalassemia	17.9%
28	Monoclonal Gammopathy of Undetermined Significance	17.6%
29	Waldenstrom Macroglobulinemia	17.4%
30	Lupus Erythematosus, Systemic	17.4%
31	Overlap syndrome	17.4%
32	Addison Disease	17.2%
33	Paraproteinemias	17.2%
34	Pemphigus	17.2%
35	Autoimmune thyroiditis	17.2%
36	Primary Adrenal Insufficiency	17.2%
37	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	17.1%
38	Autoimmune hepatitis	17.1%
39	Lymphoma, T-Cell, Cutaneous	16.9%
40	Lymphoma, AIDS-Related	16.9%
41	Enteropathy-Associated T-Cell Lymphoma	16.9%
42	Primary Effusion Lymphoma	16.9%
43	Aicardi's syndrome	16.7%
44	Transfusion Reaction	16.7%
45	Hypotensive Transfusion Reaction	16.7%
46	Granuloma	16.1%
47	Pelger-Huet Anomaly	16.1%
48	Autoimmune thrombocytopenia	16.1%
49	Immune thrombocytopenic purpura	16.1%
50	Mycosis Fungoides	16%
51	Lymphomatoid Papulosis	16%
52	Plasmablastic lymphoma	16%
53	Ichthyosis, X-Linked	15.9%
54	Hypersensitivity	15.7%
55	Immunologic Deficiency Syndromes	15.7%
56	Immune reconstitution syndrome	15.7%
57	Immune Reconstitution Inflammatory Syndrome	15.7%
58	Albinism	15.6%
59	Mucopolysaccharidosis II	15.6%
60	Lymphatic Abnormalities	15.1%
61	Muscular Dystrophy, Duchenne	15.1%
62	Chronic granulomatous disease	15%
63	Lymphomatoid Granulomatosis	15%
64	Hypergammaglobulinemia	14.9%
65	Latent Autoimmune Diabetes in Adults	14.8%
66	Alstrom Syndrome	14.8%
67	Dermatitis Herpetiformis	14.7%
68	CHARGE Syndrome	14.7%
69	Sickle Cell Trait	14.6%
70	Beckwith-Wiedemann Syndrome	14.6%
71	Lymphangiectasis, Intestinal	14.6%
72	Wolf-Hirschhorn Syndrome	14.6%
73	Rett Syndrome	14.3%
74	Neoplastic Syndromes, Hereditary	14.3%
75	Cockayne Syndrome	14.1%
76	Menkes Kinky Hair Syndrome	14.1%
77	Cystic Fibrosis	14%
78	Multiple Epiphyseal Dysplasia	13.8%
79	Osteochondrodysplasias	13.8%
80	Werner Syndrome	13.8%
81	Myasthenic Syndromes, Congenital	13.8%
82	Burkitt Lymphoma	13.1%
83	Angioedemas, Hereditary	13.1%
84	Rheumatoid Arthritis	12.9%
85	Nail-Patella Syndrome	12.9%
86	Juvenile arthritis	12.9%
87	Graves Disease	12.8%
88	Smith-Magenis syndrome	12.8%
89	Cri-du-Chat Syndrome	12.7%
90	Down Syndrome	12.7%
91	Trisomy 21	12.7%
92	Anti-Glomerular Basement Membrane Disease	12.6%
93	Adenitis	12.5%
94	Histiocytosis	12.5%
95	Leukemia, Plasma Cell	12.5%
96	Lymphadenitis	12.5%
97	Lymphangitis	12.5%
98	Lymphedema	12.5%
99	Splenic Diseases	12.5%
100	Thymus Hyperplasia	12.5%
101	Pseudolymphoma	12.5%
102	Lymphadenopathy	12.5%
103	Kartagener Syndrome	12.4%
104	Familial Mediterranean Fever	12.3%
105	Thrombasthenia	12.2%
106	Antithrombin III Deficiency	12.2%
107	Protein C Deficiency	12.2%
108	Hydrops Fetalis	12.2%
109	Holoprosencephaly	12.2%
110	Dwarfism	12.1%
111	Myasthenia Gravis, Autoimmune, Experimental	12%
112	Adrenoleukodystrophy	12%
113	Smith-Lemli-Opitz Syndrome	12%
114	Acute Chest Syndrome	11.9%
115	Sarcoidosis, Pulmonary	11.9%
116	Afibrinogenemia	11.8%
117	Factor VII Deficiency	11.8%
118	Factor X Deficiency	11.8%
119	Factor XII Deficiency	11.8%
120	Hemophilia A	11.8%
121	Activated Protein C Resistance	11.8%
122	Factor II deficiency	11.8%
123	Factor VIII Deficiency	11.8%
124	Factor V deficiency	11.8%
125	Factor XI Deficiency	11.8%
126	Hypoprothrombinemias	11.8%
127	Ataxia Telangiectasia	11.7%
128	Muscular Dystrophy	11.7%
129	Osteogenesis Imperfecta	11.7%
130	Neuronal Ceroid-Lipofuscinoses	11.7%
131	Fabry Disease	11.4%
132	POEMS Syndrome	11.3%
133	Ectodermal Dysplasia	11.3%
134	Aplasia Cutis Congenita	11.3%
135	Prader-Willi Syndrome	11.2%
136	Glycogen storage disease type II	11%
137	Refsum Disease	10.9%
138	Myotonic Dystrophy	10.9%
139	Marfan Syndrome	10.8%
140	Anemia, Diamond-Blackfan	10.8%
141	Glomerulonephritis, Membranoproliferative	10.8%
142	Sjogren-Larsson Syndrome	10.8%
143	Myasthenia Gravis	10.8%
144	Uveomeningoencephalitic Syndrome	10.8%
145	Tuberous Sclerosis	10.6%
146	Rubinstein-Taybi Syndrome	10.6%
147	Hepatolenticular Degeneration	10.6%
148	Granulomatosis with polyangiitis	10.6%
149	Dermatitis, Atopic	10.5%
150	Lymphocele	10.5%
151	Thrombocytopenic purpura	10.4%
152	Thymus Neoplasms	10.3%
153	Niemann-Pick Disease, Type C	10.3%
154	Amino Acid Metabolism, Inborn Errors	10.2%
155	Carbohydrate Metabolism, Inborn Errors	10.2%
156	Metal Metabolism, Inborn Errors	10.2%
157	Progeria	10.2%
158	Lysosomal Storage Diseases	10.2%
159	Cytochrome-c Oxidase Deficiency	10.2%
160	Peroxisomal Disorders	10.2%
161	Primary Ciliary Dyskinesia	10.2%
162	Cryoglobulinemia	10.1%
163	Polycystic Kidney Diseases	10.1%
164	Williams Syndrome	10.1%
165	Amyloid Neuropathies, Familial	9.9%
166	Galactosemias	9.9%
167	Urea Cycle Disorders, Inborn	9.9%
168	Tyrosinemias	9.9%
169	Mucopolysaccharidosis III	9.9%
170	Immune Complex Diseases	9.7%
171	Latex allergy	9.7%
172	Lymphopenia	9.7%
173	Fanconi Anemia	9.6%
174	Kallmann Syndrome	9.5%
175	Gaucher Disease	9.5%
176	Schnitzler Syndrome	9.5%
177	Stiff-Person Syndrome	9.5%
178	Polyradiculoneuropathy	9.4%
179	Polyradiculoneuritis	9.4%
180	Neuromyelitis Optica	9.4%
181	Leukoencephalitis, Acute Hemorrhagic	9.3%
182	Felty Syndrome	9.2%
183	Retinal Dysplasia	9.2%
184	Lupus Nephritis	9.2%
185	Aniridia	9.2%
186	Tay-Sachs Disease	9.1%
187	Optic Atrophy, Hereditary, Leber	9%
188	Epidermolysis Bullosa	9%
189	Hyperphosphaturia	9%
190	Cutis Laxa	8.8%
191	Mucocutaneous Lymph Node Syndrome	8.8%
192	Lupus Vasculitis, Central Nervous System	8.8%
193	Retinitis Pigmentosa	8.8%
194	Transfusion-Related Acute Lung Injury	8.8%
195	Pigmentary retinopathy	8.8%
196	Porokeratosis	8.7%
197	Keratoderma, Palmoplantar	8.7%
198	Classical Lissencephalies and Subcortical Band Heterotopias	8.7%
199	Multiple Sclerosis	8.7%
200	Canavan Disease	8.7%
201	Alexander Disease	8.7%
202	Welander Distal Myopathy	8.6%
203	Homocystinuria	8.6%
204	Immunoproliferative Disorders	8.6%
205	Deformity	8.6%
206	Leigh Disease	8.5%
207	Zellweger Syndrome	8.5%
208	Alkaptonuria	8.4%
209	Glycogen Storage Disease	8.4%
210	Hypophosphatasia	8.4%
211	Propionic acidemia	8.4%
212	Dihydropyrimidine Dehydrogenase Deficiency	8.4%
213	Cystinosis	8.4%
214	Environmental Illness	8.3%
215	Pseudoxanthoma Elasticum	8.3%
216	Vasculitis, Central Nervous System	8.3%
217	Polycystic Kidney, Autosomal Dominant	8.3%
218	Elephantiasis	8.2%
219	Hypersplenism	8.2%
220	Elephantiasis Nostras Verrucosa	8.2%
221	Rheumatoid Vasculitis	8.2%
222	Kernicterus	8.1%
223	Hyperkeratosis, Epidermolytic	8.1%
224	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.1%
225	Duane Retraction Syndrome	7.8%
226	Porphyrias, Hepatic	7.7%
227	Multiple Sclerosis, Chronic Progressive	7.6%
228	Multiple Sclerosis, Relapsing-Remitting	7.6%
229	Peutz-Jeghers Syndrome	7.6%
230	Myotonia Congenita	7.6%
231	Brain Diseases, Metabolic, Inborn	7.6%
232	Dystonia Musculorum Deformans	7.6%
233	Encephalomyelitis, Acute Disseminated	7.5%
234	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.5%
235	Glycogen Storage Disease Type I	7.5%
236	Glycogen Storage Disease Type V	7.5%
237	Neuritis, Autoimmune, Experimental	7.5%
238	Serum Sickness	7.5%
239	Asthma, Aspirin-Induced	7.5%
240	Lafora Disease	7.5%
241	Unverricht-Lundborg Syndrome	7.5%
242	Lambert-Eaton Myasthenic Syndrome	7.5%
243	Charcot-Marie-Tooth Disease	7.4%
244	Antley-Bixler Syndrome Phenotype	7.4%
245	Sicca Syndrome	7.4%
246	Sjogren's Syndrome	7.4%
247	Job Syndrome	7.3%
248	Hypolipoproteinemias	7.2%
249	Papillon-Lefevre Disease	7.2%
250	Hyperlipidemia, Familial Combined	7.2%
251	Hyperlipoproteinemia Type III	7.2%
252	Autoimmune Diseases	7.1%
253	Fetal Diseases	7.1%
254	Multiple Endocrine Neoplasia	6.9%
255	Anemia, Neonatal	6.9%
256	Histiocytic Disorders, Malignant	6.9%
257	Splenic Infarction	6.9%
258	Splenic Neoplasms	6.9%
259	Kounis Syndrome	6.9%
260	anaphylaxis	6.8%
261	Food Allergy	6.8%
262	Anaphylactic shock	6.8%
263	HIV Infections	6.8%
264	Histiocytosis, Langerhans-Cell	6.8%
265	Congenital Hypothyroidism	6.8%
266	Xeroderma Pigmentosum	6.8%
267	Klinefelter Syndrome	6.7%
268	Guillain-Barre Syndrome	6.7%
269	Hypoalphalipoproteinemias	6.4%
270	Familial Periodic Paralysis	6.4%
271	Lactose Intolerance	6.3%
272	Variegate Porphyria	6.3%
273	Acute intermittent porphyria	6.3%
274	Porphyria Cutanea Tarda	6.3%
275	Hyperhomocysteinemia	6.3%
276	Renal Aminoacidurias	6.2%
277	Fanconi Syndrome	6.2%
278	Pseudohypoaldosteronism	6.2%
279	Liddle Syndrome	6.2%
280	Hyperlipoproteinemia Type IV	6.2%
281	Hyperlipoproteinemia Type V	6.2%
282	Meconium Aspiration Syndrome	6.2%
283	Turner Syndrome	6.2%
284	Basal Cell Nevus Syndrome	6.1%
285	Lymphohistiocytosis, Hemophagocytic	6.1%
286	Erdheim-Chester Disease	6.1%
287	Behcet Syndrome	6.1%
288	Xeroderma	6%
289	Mobius Syndrome	6%
290	Splenic Rupture	5.9%
291	Respiratory Hypersensitivity	5.9%
292	Disseminated Intravascular Coagulation	5.8%
293	Protein S Deficiency	5.8%
294	Thymoma	5.8%
295	Sick Building Syndrome	5.7%
296	Multiple Chemical Sensitivity	5.7%
297	Urticaria	5.7%
298	Vasculitis, Leukocytoclastic, Cutaneous	5.7%
299	Thrombocythemia, Essential	5.7%
300	HTLV-I Infections	5.6%
301	Gout	5.6%
302	Hypokalemic periodic paralysis	5.6%
303	Multiple Endocrine Neoplasia Type 1	5.6%
304	Pseudohypoparathyroidism	5.6%
305	Cystinuria	5.6%
306	Abdominal Cramps	5.6%
307	Abnormalities, Drug-Induced	5.6%
308	Amniotic Band Syndrome	5.6%
309	Asphyxia Neonatorum	5.6%
310	Infant, Premature, Diseases	5.6%
311	Situs Inversus	5.6%
312	Infantile Colic	5.6%
313	Friedreich Ataxia	5.5%
314	Renal tubular acidosis	5.5%
315	Huntington Disease	5.5%
316	Familial Hypophosphatemic Rickets	5.5%
317	Milk Allergy	5.4%
318	Wheat Hypersensitivity	5.4%
319	Giant Cell Arteritis	5.4%
320	Temporal Arteritis	5.4%
321	Anencephaly	5.3%
322	Autoimmune Lymphoproliferative Syndrome	5.2%
323	Malignant histiocytosis	5.1%
324	Histiocytic sarcoma	5.1%
325	Myelitis, Transverse	5%
326	Nephroblastoma	5%
327	Arthritis, Gouty	5%
328	Mastocytosis	4.9%
329	Drug Eruptions	4.9%
330	Dermatitis, Allergic Contact	4.8%
331	HIV Seropositivity	4.8%
332	Eye Abnormalities	4.8%
333	Cardiovascular Abnormalities	4.8%
334	Maxillofacial Abnormalities	4.7%
335	Dural Arteriovenous Fistula	4.7%
336	Lymphoproliferative Disorders	4.7%
337	Skin Abnormalities	4.7%
338	Congenital Microtia	4.7%
339	Dextrocardia	4.6%
340	Persistent Fetal Circulation Syndrome	4.6%
341	Congenital diaphragmatic hernia	4.6%
342	Adenomatous Polyposis Coli	4.6%
343	Umbilical hernia	4.6%
344	Eosinophilic Granuloma	4.5%
345	Glycosuria, Renal	4.5%
346	Mastocytosis, Systemic	4.5%
347	Miller Fisher Syndrome	4.4%
348	Splenosis	4.3%
349	Acquired Immunodeficiency Syndrome	4.2%
350	AIDS related complex	4.2%
351	Acrocephalosyndactylia	4.2%
352	Anemia	4.2%
353	Blood Coagulation Disorders	4.2%
354	Blood Platelet Disorders	4.2%
355	Bone Marrow Diseases	4.2%
356	Hemorrhagic Disorders	4.2%
357	Leukocyte Disorders	4.2%
358	Methemoglobinemia	4.2%
359	Pancytopenia	4.2%
360	Polycythemia	4.2%
361	Sulfhemoglobinemia	4.2%
362	Thrombophilia	4.2%
363	Erythrocytosis	4.2%
364	Prune Belly Syndrome	4.1%
365	Twins, Conjoined	4.1%
366	Waardenburg Syndrome	4.1%
367	Urogenital Abnormalities	4.1%
368	Neonatal Abstinence Syndrome	4%
369	Denys-Drash Syndrome	4%
370	Microcephaly	4%
371	Macrocephaly	4%
372	Thrombocytosis	4%
373	Fetal Growth Retardation	3.9%
374	Fetal Hypoxia	3.9%
375	Congenital nystagmus	3.9%
376	Fetal Alcohol Spectrum Disorders	3.9%
377	Angioedema	3.9%
378	Bone Marrow Neoplasms	3.9%
379	Toxoplasmosis, Congenital	3.9%
380	Syphilis, Congenital	3.9%
381	Vitamin K Deficiency	3.9%
382	Acute Generalized Exanthematous Pustulosis	3.8%
383	AIDS-Related Opportunistic Infections	3.8%
384	Scimitar Syndrome	3.8%
385	MELAS Syndrome	3.8%
386	Polycythemia Vera	3.7%
387	Porencephaly	3.7%
388	HIV Wasting Syndrome	3.7%
389	AIDS Dementia Complex	3.7%
390	Craniosynostosis	3.7%
391	Syndactyly	3.7%
392	AIDS-Associated Nephropathy	3.7%
393	Brachycephaly	3.7%
394	Cleft Palate	3.5%
395	Pregnancy Complications, Hematologic	3.5%
396	Hematologic Neoplasms	3.5%
397	Anophthalmos	3.4%
398	Anus, Imperforate	3.4%
399	Hydranencephaly	3.4%
400	Microphthalmos	3.4%
401	Neural Tube Defects	3.4%
402	Paralysis, Obstetric	3.4%
403	Retinopathy of Prematurity	3.4%
404	Tethered Cord Syndrome	3.4%
405	Iniencephaly	3.4%
406	Craniorachischisis	3.4%
407	Limb Deformities, Congenital	3.4%
408	Exencephaly	3.4%
409	Septo-Optic Dysplasia	3.4%
410	Craniofacial Abnormalities	3.4%
411	Cortical Dysplasia	3.4%
412	Malformations of Cortical Development	3.4%
413	Anorectal Malformations	3.4%
414	Asthma	3.4%
415	Congenital Hyperinsulinism	3.4%
416	Bloom Syndrome	3.4%
417	Chorioamnionitis	3.4%
418	Bronchopulmonary Dysplasia	3.4%
419	Noonan Syndrome	3.4%
420	Asthma, Exercise-Induced	3.4%
421	Status Asthmaticus	3.4%
422	Hemoglobinuria, Paroxysmal	3.4%
423	Leukemoid Reaction	3.4%
424	Erythema Nodosum	3.3%
425	Dermatitis, Photoallergic	3.3%
426	HIV-Associated Lipodystrophy Syndrome	3.3%
427	Poland Syndrome	3.3%
428	Jaw Abnormalities	3.2%
429	Purpura, Thrombotic Thrombocytopenic	3.2%
430	Hereditary Angioedema Type III	3.1%
431	Hereditary Angioedema Types I and II	3.1%
432	Asthma, Occupational	3%
433	Abnormalities, Radiation-Induced	3%
434	Aspergillosis, Allergic Bronchopulmonary	3%
435	Blepharophimosis	3%
436	Laryngostenosis	3%
437	Mouth Abnormalities	3%
438	Respiratory Distress Syndrome, Newborn	3%
439	Farmer's Lung	3%
440	Esophageal Atresia	2.9%
441	Intestinal Atresia	2.9%
442	Horseshoe Kidney	2.9%
443	Pectus excavatum	2.9%
444	Klippel-Feil Syndrome	2.9%
445	Gastroschisis	2.9%
446	Synostosis	2.9%
447	Hay fever	2.9%
448	Rhinitis, Allergic, Perennial	2.9%
449	Acrodermatitis	2.9%
450	Gianotti-Crosti Syndrome	2.9%
451	Micrognathism	2.9%
452	Pierre Robin Syndrome	2.9%
453	Amelia	2.8%
454	Arachnodactyly	2.8%
455	Ectopia Cordis	2.8%
456	Ectromelia	2.8%
457	Hemimelia	2.8%
458	Meningomyelocele	2.8%
459	Phocomelia	2.8%
460	Sirenomelia	2.8%
461	Spina Bifida	2.8%
462	Polydactyly	2.8%
463	Brachydactyly	2.8%
464	Plagiocephaly	2.8%
465	Lower Extremity Deformities, Congenital	2.8%
466	Upper Extremity Deformities, Congenital	2.8%
467	Single umbilical artery	2.8%
468	Anemia, Hemolytic	2.7%
469	Anemia, Macrocytic	2.7%
470	Eosinophilia	2.7%
471	Hypoproteinemia	2.7%
472	Leukopenia	2.7%
473	Thrombocytopenia	2.7%
474	Leukostasis	2.7%
475	MYELODYSPLASTIC SYNDROME	2.7%
476	Ophthalmia Neonatorum	2.7%
477	Toxic Epidermal Necrolysis	2.7%
478	Stevens-Johnson Syndrome	2.7%
479	Retrognathia	2.6%
480	Arthrogryposis	2.6%
481	Choanal Atresia	2.6%
482	Tracheobronchomegaly	2.6%
483	Laryngocele	2.6%
484	Choledochal Cyst	2.6%
485	Hermaphroditism	2.6%
486	Disorders of Sex Development	2.6%
487	Cryptorchidism	2.6%
488	Hypospadias	2.6%
489	Central Nervous System Cysts	2.6%
490	Dandy-Walker Syndrome	2.5%
491	Dermal Sinus	2.5%
492	Leukomalacia, Periventricular	2.5%
493	Spina Bifida Cystica	2.5%
494	Spina Bifida Occulta	2.5%
495	Lissencephaly	2.5%
496	Polymicrogyria	2.5%
497	Pachygyria	2.5%
498	Schizencephaly	2.5%
499	Periventricular Nodular Heterotopia	2.5%
500	Nesidioblastosis	2.5%
501	Hyperandrogenism	2.5%
502	Prognathism	2.4%
503	Aortic coarctation	2.4%
504	Cor Triatriatum	2.4%
505	Coronary Vessel Anomalies	2.4%
506	Dental Enamel Hypoplasia	2.4%
507	Patent ductus arteriosus	2.4%
508	Ebstein Anomaly	2.4%
509	Heart Septal Defects	2.4%
510	Hyaline Membrane Disease	2.4%
511	Hypodontia	2.4%
512	Macrostomia	2.4%
513	Meningocele	2.4%
514	Microstomia	2.4%
515	Tetralogy of Fallot	2.4%
516	Transposition of Great Vessels	2.4%
517	Hypoplastic Left Heart Syndrome	2.4%
518	May-Thurner Syndrome	2.4%
519	Encephalocele	2.4%
520	Craniofacial Dysostosis	2.4%
521	Wolff-Parkinson-White Syndrome	2.4%
522	Laryngomalacia	2.3%
523	Leukocytosis	2.3%
524	Pleocytosis	2.3%
525	Pectus carinatum	2.3%
526	Hemolytic-Uremic Syndrome	2.3%
527	Bladder Exstrophy	2.3%
528	Epispadias	2.3%
529	Multicystic Dysplastic Kidney	2.3%
530	Purpura, Hyperglobulinemic	2.2%
531	Aortopulmonary Septal Defect	2.1%
532	Double Outlet Right Ventricle	2.1%
533	Endocardial Cushion Defects	2.1%
534	Myocardial bridging	2.1%
535	Aorticopulmonary Septal Defect	2.1%
536	Long QT Syndrome	2.1%
537	Platybasia	2.1%
538	Tricuspid Atresia	2.1%
539	Arrhythmogenic Right Ventricular Dysplasia	2.1%
540	Gonadal Dysgenesis	2.1%
541	Bronchomalacia	2.1%
542	Adrenogenital Syndrome	2.1%
543	Tracheomalacia	2.1%
544	Ovotesticular Disorders of Sex Development	2.1%
545	Primary Myelofibrosis	2%
546	Agranulocytosis	2%
547	Anemia, Megaloblastic	2%
548	Lymphocytosis	2%
549	Myelofibrosis	2%
550	Myeloid Metaplasia	2%
551	Hypoalbuminemia	2%
552	Hypereosinophilic syndrome	2%
553	bone marrow fibrosis	2%
554	Thrombotic Microangiopathies	2%
555	Truncus Arteriosus, Persistent	2%
556	Goldenhar Syndrome	2%
557	Atypical Hemolytic Uremic Syndrome	2%
558	Ecchymosis	1.9%
559	Petechiae	1.9%
560	Purpura	1.9%
561	Mandibulofacial Dysostosis	1.9%
562	Romano-Ward Syndrome	1.9%
563	Talipes	1.8%
564	Waterhouse-Friderichsen Syndrome	1.8%
565	Congenital clubfoot	1.7%
566	Vertical Talus	1.7%
567	Neutropenia	1.7%
568	Leukemia, Myelomonocytic, Chronic	1.7%
569	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	1.7%
570	Febrile Neutropenia	1.5%
571	Arteriovenous fistula	1.5%
572	Eosinophilia-Myalgia Syndrome	1.5%
573	Shwartzman Phenomenon	1.4%
574	Hemangioma, Cavernous	1.4%
575	Scurvy	1.4%
576	Purpura Fulminans	1.4%
577	Pulmonary Eosinophilia	1.4%
578	Eosinophilic Pneumonia	1.4%
579	Leukemia, Myeloid, Chronic-Phase	1.4%
580	Anemia, Pernicious	1.4%

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